RPL41P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)9.09402331
2ribosomal small subunit biogenesis (GO:0042274)8.83829932
3translational termination (GO:0006415)8.65095912
4maturation of SSU-rRNA (GO:0030490)8.31302248
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.51645589
6translational elongation (GO:0006414)7.45557667
7cotranslational protein targeting to membrane (GO:0006613)7.37532934
8protein targeting to ER (GO:0045047)7.31262487
9establishment of protein localization to endoplasmic reticulum (GO:0072599)7.07617705
10protein localization to endoplasmic reticulum (GO:0070972)6.86930247
11cellular protein complex disassembly (GO:0043624)6.63102969
12viral life cycle (GO:0019058)6.60515294
13nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.53257995
14ribosomal large subunit biogenesis (GO:0042273)6.34262275
15translational initiation (GO:0006413)6.03828560
16protein complex disassembly (GO:0043241)5.63064117
17heterochromatin organization (GO:0070828)5.36052217
18macromolecular complex disassembly (GO:0032984)5.29498969
19ribonucleoprotein complex biogenesis (GO:0022613)5.14853300
20protein targeting to membrane (GO:0006612)5.14527857
21negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.74991216
22translation (GO:0006412)4.67838670
23nuclear-transcribed mRNA catabolic process (GO:0000956)4.51005389
24positive regulation of monocyte chemotaxis (GO:0090026)4.43565835
25pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.34908981
26DNA replication-dependent nucleosome assembly (GO:0006335)4.27126992
27DNA replication-dependent nucleosome organization (GO:0034723)4.27126992
28mRNA catabolic process (GO:0006402)4.25192580
29nucleobase-containing small molecule interconversion (GO:0015949)4.17420986
30RNA catabolic process (GO:0006401)3.90862307
31rRNA processing (GO:0006364)3.88490550
32cellular component biogenesis (GO:0044085)3.80963056
33eosinophil chemotaxis (GO:0048245)3.76590383
34rRNA metabolic process (GO:0016072)3.71815135
35positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.68224824
36positive regulation of T cell chemotaxis (GO:0010820)3.67223620
37regulation of T cell chemotaxis (GO:0010819)3.67223620
38energy coupled proton transport, down electrochemical gradient (GO:0015985)3.67152630
39ATP synthesis coupled proton transport (GO:0015986)3.67152630
40ncRNA 3-end processing (GO:0043628)3.67003366
41establishment of protein localization to mitochondrial membrane (GO:0090151)3.65954124
42chromatin assembly (GO:0031497)3.64837895
43pyrimidine nucleotide catabolic process (GO:0006244)3.59171714
44ribosome biogenesis (GO:0042254)3.48499246
45glycosphingolipid catabolic process (GO:0046479)3.46187794
46Arp2/3 complex-mediated actin nucleation (GO:0034314)3.43585803
47eosinophil migration (GO:0072677)3.42794144
48regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.42413300
49establishment of protein localization to membrane (GO:0090150)3.38605067
50pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.31033979
51pattern specification involved in kidney development (GO:0061004)3.29323663
52DNA unwinding involved in DNA replication (GO:0006268)3.27506464
53protein targeting (GO:0006605)3.21725271
54formation of translation preinitiation complex (GO:0001731)3.11560420
55glycolipid catabolic process (GO:0019377)3.08785337
56establishment of protein localization to organelle (GO:0072594)3.08557768
57DNA strand elongation involved in DNA replication (GO:0006271)3.03506514
58actin nucleation (GO:0045010)3.02284490
59DNA strand elongation (GO:0022616)3.02155802
60base-excision repair, AP site formation (GO:0006285)3.01137232
61ceramide catabolic process (GO:0046514)2.97594632
62innate immune response in mucosa (GO:0002227)2.92632146
63negative regulation of T cell differentiation in thymus (GO:0033085)2.90556878
64protein localization to membrane (GO:0072657)2.89868311
65auditory receptor cell differentiation (GO:0042491)2.87113896
66mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.87061703
67inner mitochondrial membrane organization (GO:0007007)2.86714381
68positive regulation of muscle cell apoptotic process (GO:0010661)2.86341472
69pseudouridine synthesis (GO:0001522)2.85153942
70protein maturation by protein folding (GO:0022417)2.84613856
71deoxyribose phosphate catabolic process (GO:0046386)2.81998970
72chromatin remodeling at centromere (GO:0031055)2.78780984
73protein localization to chromosome, centromeric region (GO:0071459)2.78704078
74rRNA transcription (GO:0009303)2.77707919
75chromatin assembly or disassembly (GO:0006333)2.76789482
76maturation of 5.8S rRNA (GO:0000460)2.76171781
77regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.75103610
78deoxyribonucleotide catabolic process (GO:0009264)2.73179695
79regulation of monocyte chemotaxis (GO:0090025)2.72960079
80telomere maintenance via semi-conservative replication (GO:0032201)2.72106813
81replicative senescence (GO:0090399)2.71423219
82CENP-A containing nucleosome assembly (GO:0034080)2.69198910
83pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.65049296
84regulation of protein heterodimerization activity (GO:0043497)2.64083420
85regulation of lymphocyte chemotaxis (GO:1901623)2.63703852
86ncRNA processing (GO:0034470)2.62802076
87behavioral response to nicotine (GO:0035095)2.62331847
88chaperone-mediated protein transport (GO:0072321)2.62113164
89skeletal muscle tissue regeneration (GO:0043403)2.61309283
90regulation of megakaryocyte differentiation (GO:0045652)2.61242157
91folic acid metabolic process (GO:0046655)2.56957230
92interleukin-1-mediated signaling pathway (GO:0070498)2.56060465
93keratinocyte development (GO:0003334)2.54062564
94regulation of prostaglandin secretion (GO:0032306)2.53672177
95lens fiber cell differentiation (GO:0070306)2.52675310
96pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.49650216
97protein targeting to mitochondrion (GO:0006626)2.46527075
98regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.44422460
99CTP metabolic process (GO:0046036)2.42572292
100ribosomal small subunit assembly (GO:0000028)10.5611536

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.39309358
2E2F7_22180533_ChIP-Seq_HELA_Human4.43392457
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.37180247
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.39440153
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.31183255
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.28213016
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.07811275
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.06597426
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.05211487
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.03678094
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.85342027
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.73445064
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.72831844
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.72829556
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.71902102
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.64776592
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.57672813
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.57555112
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53556155
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.39605153
21XRN2_22483619_ChIP-Seq_HELA_Human2.36279239
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.29958441
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.17055005
24ELK1_19687146_ChIP-ChIP_HELA_Human2.14111424
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.11026685
26TTF2_22483619_ChIP-Seq_HELA_Human2.06024902
27VDR_23849224_ChIP-Seq_CD4+_Human1.99877907
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.98594189
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.96610628
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95143454
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.90925779
32TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86929199
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.86050906
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.85426391
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82584582
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.80632309
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.80359641
38CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.80217846
39FOXP3_21729870_ChIP-Seq_TREG_Human1.78299896
40DCP1A_22483619_ChIP-Seq_HELA_Human1.75556764
41VDR_21846776_ChIP-Seq_THP-1_Human1.72721666
42KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.71454026
43MYC_18940864_ChIP-ChIP_HL60_Human1.70664360
44ERG_20887958_ChIP-Seq_HPC-7_Mouse1.68844644
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68468006
46CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.65603405
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63718287
48DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.63564144
49GABP_19822575_ChIP-Seq_HepG2_Human1.62833075
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50687020
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42445887
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42146996
53SOX2_18555785_ChIP-Seq_MESCs_Mouse1.41667076
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.41167413
55SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.36699479
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36301280
57ZNF263_19887448_ChIP-Seq_K562_Human1.35835052
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.35638005
59PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.30032732
60AR_21909140_ChIP-Seq_LNCAP_Human1.29369525
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21055138
62E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20899430
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.20231815
64HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.18181692
65TP63_17297297_ChIP-ChIP_HaCaT_Human1.16215079
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.13618703
67SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.13539670
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12262449
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11226860
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10213275
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08581412
72SOX2_16153702_ChIP-ChIP_HESCs_Human1.07767332
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06029359
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05844302
75MYCN_18555785_ChIP-Seq_MESCs_Mouse1.05693968
76TFEB_21752829_ChIP-Seq_HELA_Human1.05248697
77ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04958428
78GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03106922
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01179733
80SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99601290
81SOX17_20123909_ChIP-Seq_XEN_Mouse0.97836721
82KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95629116
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95582621
84ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94657203
85CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93964753
86IRF1_19129219_ChIP-ChIP_H3396_Human0.92478042
87KDM5A_27292631_Chip-Seq_BREAST_Human0.92097019
88TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.91427191
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90214903
90CIITA_25753668_ChIP-Seq_RAJI_Human0.89998542
91SPI1_23547873_ChIP-Seq_NB4_Human0.89416791
92NANOG_18555785_ChIP-Seq_MESCs_Mouse0.88006673
93ELK1_22589737_ChIP-Seq_MCF10A_Human0.87066947
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86660482
95RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.83975070
96BRD4_27068464_Chip-Seq_AML-cells_Mouse0.83331480
97STAT4_19710469_ChIP-ChIP_TH1__Mouse0.81052603
98E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.77173934
99SRY_22984422_ChIP-ChIP_TESTIS_Rat0.77101024
100SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.76799118

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation8.82042700
2MP0002877_abnormal_melanocyte_morpholog5.20510160
3MP0010307_abnormal_tumor_latency2.42246695
4MP0008007_abnormal_cellular_replicative2.38311882
5MP0006292_abnormal_olfactory_placode2.28475489
6MP0009333_abnormal_splenocyte_physiolog2.25495171
7MP0001188_hyperpigmentation2.21534580
8MP0004957_abnormal_blastocyst_morpholog2.05296282
9MP0009053_abnormal_anal_canal1.98039528
10MP0008057_abnormal_DNA_replication1.92122881
11MP0002090_abnormal_vision1.89575406
12MP0010234_abnormal_vibrissa_follicle1.79353909
13MP0005623_abnormal_meninges_morphology1.78511451
14MP0003111_abnormal_nucleus_morphology1.73124935
15MP0003786_premature_aging1.71290254
16MP0003077_abnormal_cell_cycle1.69167902
17MP0000604_amyloidosis1.68965862
18MP0003123_paternal_imprinting1.67552824
19MP0005197_abnormal_uvea_morphology1.60978557
20MP0002092_abnormal_eye_morphology1.55979909
21MP0006082_CNS_inflammation1.55034509
22MP0010678_abnormal_skin_adnexa1.54328462
23MP0010094_abnormal_chromosome_stability1.53859673
24MP0000383_abnormal_hair_follicle1.51041609
25MP0000537_abnormal_urethra_morphology1.48557277
26MP0002102_abnormal_ear_morphology1.46933246
27MP0000750_abnormal_muscle_regeneration1.45556072
28MP0002095_abnormal_skin_pigmentation1.43850004
29MP0002163_abnormal_gland_morphology1.43563796
30MP0010386_abnormal_urinary_bladder1.41702902
31MP0001186_pigmentation_phenotype1.40369014
32MP0001853_heart_inflammation1.39358742
33MP0004185_abnormal_adipocyte_glucose1.38440045
34MP0009840_abnormal_foam_cell1.37207097
35MP0003191_abnormal_cellular_cholesterol1.36183602
36MP0000427_abnormal_hair_cycle1.35325284
37MP0001919_abnormal_reproductive_system1.33174126
38MP0003011_delayed_dark_adaptation1.32215758
39MP0000372_irregular_coat_pigmentation1.32038316
40MP0000371_diluted_coat_color1.30815033
41MP0003646_muscle_fatigue1.30215179
42MP0008058_abnormal_DNA_repair1.28028970
43MP0000343_altered_response_to1.24841916
44MP0003693_abnormal_embryo_hatching1.21258627
45MP0005389_reproductive_system_phenotype1.19784306
46MP0000428_abnormal_craniofacial_morphol1.17485911
47MP0002160_abnormal_reproductive_system1.16524621
48MP0005193_abnormal_anterior_eye1.15830233
49MP0001727_abnormal_embryo_implantation1.14638899
50MP0000490_abnormal_crypts_of1.12522802
51MP0005379_endocrine/exocrine_gland_phen1.08863672
52MP0005167_abnormal_blood-brain_barrier1.08734918
53MP0002098_abnormal_vibrissa_morphology1.08559785
54MP0003690_abnormal_glial_cell1.08496060
55MP0001324_abnormal_eye_pigmentation1.05259529
56MP0002697_abnormal_eye_size1.02991372
57MP0005174_abnormal_tail_pigmentation1.00225115
58MP0000015_abnormal_ear_pigmentation0.99630026
59MP0003329_amyloid_beta_deposits0.99075635
60MP0001293_anophthalmia0.97029857
61MP0001881_abnormal_mammary_gland0.96912397
62MP0005391_vision/eye_phenotype0.95608802
63MP0003705_abnormal_hypodermis_morpholog0.94520441
64MP0005501_abnormal_skin_physiology0.93321529
65MP0004019_abnormal_vitamin_homeostasis0.91725370
66MP0005195_abnormal_posterior_eye0.91317776
67MP0000647_abnormal_sebaceous_gland0.89755944
68MP0005645_abnormal_hypothalamus_physiol0.88285226
69MP0002075_abnormal_coat/hair_pigmentati0.88127073
70MP0009384_cardiac_valve_regurgitation0.87823479
71MP0008932_abnormal_embryonic_tissue0.87149593
72MP0000627_abnormal_mammary_gland0.86187159
73MP0000358_abnormal_cell_content/0.86158143
74MP0005408_hypopigmentation0.85791994
75MP0001286_abnormal_eye_development0.85591608
76MP0003942_abnormal_urinary_system0.85184900
77MP0003453_abnormal_keratinocyte_physiol0.85059493
78MP0005423_abnormal_somatic_nervous0.83095499
79MP0000377_abnormal_hair_follicle0.83049271
80MP0001440_abnormal_grooming_behavior0.82283416
81MP0004130_abnormal_muscle_cell0.81578291
82MP0000681_abnormal_thyroid_gland0.81263497
83MP0001661_extended_life_span0.76519599
84MP0002796_impaired_skin_barrier0.74192031
85MP0002210_abnormal_sex_determination0.73868779
86MP0000049_abnormal_middle_ear0.72917567
87MP0002148_abnormal_hypersensitivity_rea0.72833389
88MP0001835_abnormal_antigen_presentation0.71475786
89MP0003632_abnormal_nervous_system0.70584136
90MP0002419_abnormal_innate_immunity0.70126846
91MP0002998_abnormal_bone_remodeling0.69892647
92MP0001542_abnormal_bone_strength0.69497761
93MP0001348_abnormal_lacrimal_gland0.69294188
94MP0008789_abnormal_olfactory_epithelium0.68681512
95MP0010030_abnormal_orbit_morphology0.68389266
96MP0005257_abnormal_intraocular_pressure0.67815378
97MP0000465_gastrointestinal_hemorrhage0.66608717
98MP0006035_abnormal_mitochondrial_morpho0.66361468
99MP0000733_abnormal_muscle_development0.64461201
100MP0003718_maternal_effect0.62797385

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.85608054
2Reticulocytopenia (HP:0001896)6.06340240
3Abnormal number of erythroid precursors (HP:0012131)5.87790302
4Aplasia/Hypoplasia of the sacrum (HP:0008517)5.56469482
5Autoimmune thrombocytopenia (HP:0001973)4.48422896
6Cutaneous melanoma (HP:0012056)4.39865915
7Macrocytic anemia (HP:0001972)4.15268518
8Abnormality of glycolipid metabolism (HP:0010969)3.84927632
9Abnormality of liposaccharide metabolism (HP:0010968)3.84927632
10Abnormality of glycosphingolipid metabolism (HP:0004343)3.84927632
11Pallor (HP:0000980)3.80647091
12Vacuolated lymphocytes (HP:0001922)3.63761878
13Selective tooth agenesis (HP:0001592)3.54556457
14Squamous cell carcinoma (HP:0002860)3.28723431
15Thrombocytosis (HP:0001894)3.25044833
16Absent thumb (HP:0009777)3.20795906
17Short middle phalanx of the 5th finger (HP:0004220)3.12587475
18Aplastic anemia (HP:0001915)3.11847589
19Multiple enchondromatosis (HP:0005701)2.97331297
20Multiple lipomas (HP:0001012)2.91842575
21Myocardial infarction (HP:0001658)2.87058414
22Radial bowing (HP:0002986)2.59604700
23Chromosomal breakage induced by crosslinking agents (HP:0003221)2.54057797
24Increased cerebral lipofuscin (HP:0011813)2.51307672
25Tetraparesis (HP:0002273)2.47315443
26Spastic diplegia (HP:0001264)2.47029715
27Sensory axonal neuropathy (HP:0003390)2.39332213
28Upper motor neuron abnormality (HP:0002127)2.30687653
29Dry hair (HP:0011359)2.26705738
30Aplasia involving bones of the extremities (HP:0009825)2.21326337
31Aplasia involving bones of the upper limbs (HP:0009823)2.21326337
32Aplasia of the phalanges of the hand (HP:0009802)2.21326337
33Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.20631110
34Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.18728656
35Acute necrotizing encephalopathy (HP:0006965)2.17813403
36Lipid accumulation in hepatocytes (HP:0006561)2.16815438
37Pseudobulbar signs (HP:0002200)2.16109561
38Pendular nystagmus (HP:0012043)2.15021402
39Abnormality of the phalanges of the 5th finger (HP:0004213)2.14645115
40Increased hepatocellular lipid droplets (HP:0006565)2.11787608
41Spinal cord lesions (HP:0100561)2.11348114
42Syringomyelia (HP:0003396)2.11348114
43Abnormal mitochondria in muscle tissue (HP:0008316)2.11145710
44Long nose (HP:0003189)2.10012731
45Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.06593153
46Absent rod-and cone-mediated responses on ERG (HP:0007688)2.05059358
47Recurrent abscess formation (HP:0002722)2.04220712
48Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.00779323
49Abnormality of DNA repair (HP:0003254)1.99065300
50Recurrent gram-negative bacterial infections (HP:0005420)1.92988152
51Periodontitis (HP:0000704)1.92386007
52Maternal diabetes (HP:0009800)1.91599708
53Broad distal phalanx of finger (HP:0009836)1.89845438
5411 pairs of ribs (HP:0000878)1.89051039
55Duplication of thumb phalanx (HP:0009942)1.88742169
56Renal Fanconi syndrome (HP:0001994)1.88230213
57Dysphonia (HP:0001618)1.87968658
58Chromsome breakage (HP:0040012)1.87635668
59Abnormality of the columella (HP:0009929)1.86658276
60Partial duplication of thumb phalanx (HP:0009944)1.86380046
61Progressive muscle weakness (HP:0003323)1.86247840
62Increased intramyocellular lipid droplets (HP:0012240)1.86177753
63Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.85355846
64Entropion (HP:0000621)1.85084193
65Triphalangeal thumb (HP:0001199)1.84434111
66Short nail (HP:0001799)1.83698388
67Thick lower lip vermilion (HP:0000179)1.81814079
68Osteolytic defects of the phalanges of the hand (HP:0009771)1.81660644
69Osteolytic defects of the hand bones (HP:0009699)1.81660644
70Colon cancer (HP:0003003)1.81179779
71Hypoplasia of the radius (HP:0002984)1.80844855
72Fragile nails (HP:0001808)1.80004315
73Aplasia/Hypoplasia of the uvula (HP:0010293)1.79958451
74Stenosis of the external auditory canal (HP:0000402)1.79769527
75Mitochondrial inheritance (HP:0001427)1.79748908
76Bowed forearm bones (HP:0003956)1.74745402
77Bowing of the arm (HP:0006488)1.74745402
78Short thumb (HP:0009778)1.74100710
79Short chin (HP:0000331)1.73726361
80Abnormality of the distal phalanges of the toes (HP:0010182)1.73383906
81Hyperparathyroidism (HP:0000843)1.72503778
82Sparse scalp hair (HP:0002209)1.72367924
83Esophageal neoplasm (HP:0100751)1.72013206
84Neoplasm of head and neck (HP:0012288)1.72013206
85Absent frontal sinuses (HP:0002688)1.71562705
86Poor head control (HP:0002421)1.70060101
87Prostate neoplasm (HP:0100787)1.69159014
88Deep palmar crease (HP:0006191)1.69080115
89Hypercalcemia (HP:0003072)1.65874771
90Acute lymphatic leukemia (HP:0006721)1.63993691
91Melanoma (HP:0002861)1.63070091
92Acute encephalopathy (HP:0006846)1.62987412
93Decreased activity of mitochondrial respiratory chain (HP:0008972)1.62750907
94Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.62750907
95Partial duplication of the phalanx of hand (HP:0009999)1.62264345
96Abnormality of the preputium (HP:0100587)1.61899988
97Abnormality of macrophages (HP:0004311)1.61437402
98Pancytopenia (HP:0001876)1.60893976
99Cerebellar dysplasia (HP:0007033)1.60250876
100Depressed nasal ridge (HP:0000457)1.60175945

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.37961084
2PBK3.81814138
3STK243.32425359
4IRAK32.98172372
5TTN2.63191223
6FLT32.48452915
7ZAK2.45254162
8CDC72.41964730
9EEF2K2.38154489
10ERBB42.33156423
11BUB12.27412858
12TLK12.27099479
13ABL21.86663457
14RPS6KB21.83947954
15AURKA1.82401738
16PDK21.80975075
17ILK1.75134957
18SCYL21.61281421
19STK161.49280870
20BRSK21.42066478
21NEK11.35230303
22MAP2K71.33469035
23BRAF1.28768976
24CAMKK21.23128880
25LIMK11.19019498
26CDK81.18260215
27RPS6KA41.18143968
28RPS6KC11.14274067
29RPS6KL11.14274067
30RPS6KA21.14170102
31AURKB1.12151089
32KIT1.09243152
33RPS6KA61.08834172
34STK31.07881754
35PIM21.07106731
36TAF11.06262908
37CHEK21.06205385
38MAP2K21.02387479
39NEK21.01227047
40BMPR20.96759755
41LRRK20.95326155
42PLK10.90669492
43ATR0.90217270
44MAP3K90.89218620
45TESK20.89014937
46PASK0.88001567
47RPS6KA50.87680442
48EIF2AK10.84545707
49IKBKB0.84413633
50SMG10.83546846
51SRPK10.82319226
52WEE10.81702882
53BCKDK0.77459113
54MAP3K80.77165853
55STK38L0.77136770
56RPS6KB10.75400714
57CSF1R0.70884411
58IRAK20.70789517
59STK100.70697694
60ARAF0.67348671
61ERBB30.66497123
62VRK20.66194819
63PIK3CG0.65457525
64MAPK120.63693084
65CDK40.63013621
66MUSK0.61826720
67TRPM70.60416425
68CDK70.58026112
69LATS20.56626427
70RPS6KA10.56169029
71PAK20.56043889
72TTK0.56009671
73DAPK10.55042116
74ACVR1B0.55021506
75VRK10.54388156
76MAP3K100.54047071
77MAP3K110.53535337
78AKT20.52972790
79MAP3K120.52742531
80DAPK30.52564344
81CSNK2A20.52052105
82STK40.46960687
83CDK60.46365181
84EIF2AK30.46134354
85MOS0.45882771
86NEK90.45669918
87GRK70.44178050
88MKNK10.43968384
89MAPKAPK50.42149437
90DYRK30.42141918
91ADRBK20.40999462
92CSNK2A10.40411211
93CHEK10.39690496
94PRKCD0.39593831
95PRKCQ0.39483320
96ATM0.39259552
97CAMK2B0.38632654
98MAPKAPK30.37624317
99TGFBR10.35836873
100DYRK20.34738683

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.64786671
2Systemic lupus erythematosus_Homo sapiens_hsa053224.39476397
3DNA replication_Homo sapiens_hsa030303.50571919
4Alcoholism_Homo sapiens_hsa050343.08923792
5Oxidative phosphorylation_Homo sapiens_hsa001903.03693043
6RNA polymerase_Homo sapiens_hsa030202.58738578
7Parkinsons disease_Homo sapiens_hsa050122.27687551
8Nucleotide excision repair_Homo sapiens_hsa034202.27123752
9Mismatch repair_Homo sapiens_hsa034302.25600734
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.09894536
11Pyrimidine metabolism_Homo sapiens_hsa002402.07090905
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.98327985
13Sulfur relay system_Homo sapiens_hsa041221.91585203
14Alzheimers disease_Homo sapiens_hsa050101.77941157
15Huntingtons disease_Homo sapiens_hsa050161.70426588
16Fanconi anemia pathway_Homo sapiens_hsa034601.69012154
17Viral carcinogenesis_Homo sapiens_hsa052031.65355861
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.64244788
19Base excision repair_Homo sapiens_hsa034101.63436735
20Cell cycle_Homo sapiens_hsa041101.59523465
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.54165944
22RNA transport_Homo sapiens_hsa030131.51438428
23Homologous recombination_Homo sapiens_hsa034401.50529817
24Basal transcription factors_Homo sapiens_hsa030221.40696822
25Spliceosome_Homo sapiens_hsa030401.37099323
26Lysosome_Homo sapiens_hsa041421.34255639
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32261736
28Proteasome_Homo sapiens_hsa030501.31145729
29Cardiac muscle contraction_Homo sapiens_hsa042601.22294796
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22266003
31Other glycan degradation_Homo sapiens_hsa005111.15547425
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12803477
33Selenocompound metabolism_Homo sapiens_hsa004501.11731339
34Rheumatoid arthritis_Homo sapiens_hsa053231.10610472
35Bladder cancer_Homo sapiens_hsa052191.08915876
36Purine metabolism_Homo sapiens_hsa002301.01072971
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00980494
38p53 signaling pathway_Homo sapiens_hsa041150.96353521
39Sphingolipid metabolism_Homo sapiens_hsa006000.91418877
40Phagosome_Homo sapiens_hsa041450.91266449
41RNA degradation_Homo sapiens_hsa030180.90615199
42One carbon pool by folate_Homo sapiens_hsa006700.87301895
43Sulfur metabolism_Homo sapiens_hsa009200.85647432
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83464521
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80022316
46Collecting duct acid secretion_Homo sapiens_hsa049660.70997798
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.67304668
48Ether lipid metabolism_Homo sapiens_hsa005650.67287080
49Small cell lung cancer_Homo sapiens_hsa052220.65909909
50Legionellosis_Homo sapiens_hsa051340.65825758
51Steroid biosynthesis_Homo sapiens_hsa001000.65687127
52Antigen processing and presentation_Homo sapiens_hsa046120.60276594
53Glutathione metabolism_Homo sapiens_hsa004800.60258170
54N-Glycan biosynthesis_Homo sapiens_hsa005100.58992751
55Salmonella infection_Homo sapiens_hsa051320.58332567
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.57817456
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57155911
58Malaria_Homo sapiens_hsa051440.54756009
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54485703
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52631056
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.52621172
62Melanoma_Homo sapiens_hsa052180.49381762
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46323335
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45984384
65Metabolic pathways_Homo sapiens_hsa011000.45721339
66Apoptosis_Homo sapiens_hsa042100.43018735
67Basal cell carcinoma_Homo sapiens_hsa052170.42620658
68HTLV-I infection_Homo sapiens_hsa051660.40300658
69Non-homologous end-joining_Homo sapiens_hsa034500.40281164
70Hematopoietic cell lineage_Homo sapiens_hsa046400.39216246
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38516223
72Protein export_Homo sapiens_hsa030600.37578262
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36880260
74Shigellosis_Homo sapiens_hsa051310.35109928
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34816441
76Pancreatic cancer_Homo sapiens_hsa052120.32420425
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31922293
78Hippo signaling pathway_Homo sapiens_hsa043900.30894935
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.30446200
80Vitamin B6 metabolism_Homo sapiens_hsa007500.28826754
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26741386
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25570722
83Pyruvate metabolism_Homo sapiens_hsa006200.25310826
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.23096643
85Fatty acid biosynthesis_Homo sapiens_hsa000610.21692785
86mRNA surveillance pathway_Homo sapiens_hsa030150.20787290
87Epstein-Barr virus infection_Homo sapiens_hsa051690.18210339
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.18001077
89TGF-beta signaling pathway_Homo sapiens_hsa043500.17979623
90Pathways in cancer_Homo sapiens_hsa052000.17486442
91Non-small cell lung cancer_Homo sapiens_hsa052230.17370365
92Colorectal cancer_Homo sapiens_hsa052100.17201965
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16996771
94Thyroid cancer_Homo sapiens_hsa052160.16954294
95Folate biosynthesis_Homo sapiens_hsa007900.16845106
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15244408
97Linoleic acid metabolism_Homo sapiens_hsa005910.14429563
98Hedgehog signaling pathway_Homo sapiens_hsa043400.12405842
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.12318984
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.12158633

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