RPL41P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)8.63332025
2negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 8.18129788
3maturation of 5.8S rRNA (GO:0000460)7.87685476
4ribosomal small subunit assembly (GO:0000028)7.80200331
5positive regulation of translational initiation (GO:0045948)7.27817468
6positive regulation of signal transduction by p53 class mediator (GO:1901798)6.91456421
7regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 6.89943256
8negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)6.72426755
9ribosomal small subunit biogenesis (GO:0042274)6.40349149
10secretory granule organization (GO:0033363)6.13385675
11positive regulation of glycoprotein biosynthetic process (GO:0010560)5.87248114
12ubiquinone biosynthetic process (GO:0006744)5.55857483
13regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)5.53522036
14regulation of protein glycosylation (GO:0060049)5.36219325
15platelet formation (GO:0030220)5.22095037
16ubiquinone metabolic process (GO:0006743)4.97925348
17quinone biosynthetic process (GO:1901663)4.73154510
18viral transcription (GO:0019083)4.71813079
19positive regulation of glycoprotein metabolic process (GO:1903020)4.69873802
20negative regulation of glycogen biosynthetic process (GO:0045719)4.67661114
21positive regulation of macrophage differentiation (GO:0045651)4.64506241
22negative regulation of signal transduction by p53 class mediator (GO:1901797)4.61112956
23myeloid cell development (GO:0061515)4.58657044
24cytochrome complex assembly (GO:0017004)4.52493306
25translational termination (GO:0006415)4.43549726
26regulation of mitochondrial translation (GO:0070129)4.38213364
27positive regulation of gamma-delta T cell activation (GO:0046645)4.24208554
28regulation of energy homeostasis (GO:2000505)4.10872710
29T cell apoptotic process (GO:0070231)4.08831035
30regulation of cellular respiration (GO:0043457)4.06315402
31regulation of B cell differentiation (GO:0045577)3.97993900
32fusion of sperm to egg plasma membrane (GO:0007342)3.93062722
33protein heterotetramerization (GO:0051290)3.91156658
34negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230)3.87143054
35negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.84446158
36negative regulation of glycogen metabolic process (GO:0070874)3.81384741
37tolerance induction (GO:0002507)3.77869978
38necroptotic process (GO:0070266)3.77146845
39ncRNA 3-end processing (GO:0043628)3.76906425
40negative regulation of translational initiation (GO:0045947)3.73979114
41regulation of interleukin-12 biosynthetic process (GO:0045075)3.72180480
42regulation of gamma-delta T cell differentiation (GO:0045586)3.63255909
43regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)3.62081500
44neutrophil activation involved in immune response (GO:0002283)3.60340596
45positive regulation of mast cell degranulation (GO:0043306)3.55893455
46positive regulation of mast cell activation involved in immune response (GO:0033008)3.55893455
47production of molecular mediator involved in inflammatory response (GO:0002532)3.53613196
48SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.53426173
49cotranslational protein targeting to membrane (GO:0006613)3.49771058
50negative regulation of membrane potential (GO:0045837)3.48406530
51interleukin-6-mediated signaling pathway (GO:0070102)3.46932941
52negative regulation of cardiac muscle hypertrophy (GO:0010614)3.45805833
53erythrocyte maturation (GO:0043249)3.44515283
54protein targeting to ER (GO:0045047)3.43705496
55regulation of regulatory T cell differentiation (GO:0045589)3.40179524
56neutrophil activation (GO:0042119)3.39513035
57lymphocyte apoptotic process (GO:0070227)3.39204143
58diacylglycerol metabolic process (GO:0046339)3.37246182
59positive regulation of T cell apoptotic process (GO:0070234)3.30135387
60cellular response to interleukin-15 (GO:0071350)3.28538652
61spermatid nucleus differentiation (GO:0007289)3.28468341
62cellular protein complex disassembly (GO:0043624)3.26186669
63positive regulation of mast cell activation (GO:0033005)3.24044970
64establishment of protein localization to endoplasmic reticulum (GO:0072599)3.24020213
65positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.22475367
66activated T cell proliferation (GO:0050798)3.22451069
67protein localization to endoplasmic reticulum (GO:0070972)3.21964740
68negative regulation of muscle hypertrophy (GO:0014741)3.19635039
69membrane tubulation (GO:0097320)3.19132037
70viral life cycle (GO:0019058)3.18959505
71positive regulation of fat cell differentiation (GO:0045600)3.15710401
72translational elongation (GO:0006414)3.15505441
73regulation of necrotic cell death (GO:0010939)3.15175661
74nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.14071534
75leukotriene biosynthetic process (GO:0019370)3.13772157
76protein insertion into membrane (GO:0051205)3.10792088
77piRNA metabolic process (GO:0034587)3.10634656
78plasma membrane fusion (GO:0045026)3.03710511
79regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902229)3.00792639
80protein kinase B signaling (GO:0043491)3.00092082
81granulocyte activation (GO:0036230)3.00022087
82neutrophil chemotaxis (GO:0030593)2.95444532
83regulation of gamma-delta T cell activation (GO:0046643)2.95439201
84cellular anion homeostasis (GO:0030002)2.93583148
85heterotypic cell-cell adhesion (GO:0034113)2.93209775
86granulocyte chemotaxis (GO:0071621)2.92673831
87neutrophil migration (GO:1990266)2.90993623
88positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.90135053
89granulocyte migration (GO:0097530)2.85077990
90fibril organization (GO:0097435)2.84215124
91response to nitrosative stress (GO:0051409)2.83434626
92regulation of hypersensitivity (GO:0002883)2.82647852
93translational initiation (GO:0006413)2.81507769
94regulation of oxidative stress-induced neuron death (GO:1903203)2.80590910
95leukocyte cell-cell adhesion (GO:0007159)2.79279951
96regulation of translation in response to stress (GO:0043555)2.73537767
97galactose catabolic process (GO:0019388)2.70747699
98RNA localization (GO:0006403)11.2872075
99signal complex assembly (GO:0007172)10.6311498
100megakaryocyte development (GO:0035855)10.0604254

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.97112341
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.14076259
3SRY_22984422_ChIP-ChIP_TESTIS_Rat3.69650178
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.67262879
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.97530685
6EGR1_19032775_ChIP-ChIP_M12_Human2.87901947
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.85068858
8CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.69253060
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.55874676
10TP53_16413492_ChIP-PET_HCT116_Human2.49118432
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.33314358
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.30569821
13PCGF2_27294783_Chip-Seq_NPCs_Mouse2.24051956
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.19019254
15CEBPB_26923725_Chip-Seq_MESODERM_Mouse2.10574282
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.03097509
17GBX2_23144817_ChIP-Seq_PC3_Human1.94548663
18AR_21572438_ChIP-Seq_LNCaP_Human1.92799224
19VDR_22108803_ChIP-Seq_LS180_Human1.89555057
20SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.88421256
21RUNX_20019798_ChIP-Seq_JUKART_Human1.87687077
22ERG_21242973_ChIP-ChIP_JURKAT_Human1.87210947
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.82958181
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.79631123
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.69309568
26AHR_22903824_ChIP-Seq_MCF-7_Human1.69018238
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.66805132
28EZH2_22144423_ChIP-Seq_EOC_Human1.66660637
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.60166230
30TBX3_20139965_ChIP-Seq_ESCs_Mouse1.59103749
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.58866413
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.58866413
33RNF2_27304074_Chip-Seq_NSC_Mouse1.58493287
34TBX3_20139965_ChIP-Seq_MESCs_Mouse1.58304858
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.56420577
36P53_22127205_ChIP-Seq_FIBROBLAST_Human1.55779031
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.54154081
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.52990081
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52661353
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.50487017
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43797638
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43645101
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.42300816
44CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37712705
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37526222
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.36014646
47TDRD3_21172665_ChIP-Seq_MCF-7_Human1.35579437
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.35457528
49SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.35138806
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30985694
51TRIM28_21343339_ChIP-Seq_HEK293_Human1.29265421
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.28365495
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.25833771
54DROSHA_22980978_ChIP-Seq_HELA_Human1.25596127
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22269582
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.20535182
57PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.19273180
58SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18192752
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14912195
60STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.12739964
61ARNT_22903824_ChIP-Seq_MCF-7_Human1.10970358
62SOX2_21211035_ChIP-Seq_LN229_Human1.09587502
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08414814
64TAF2_19829295_ChIP-Seq_ESCs_Human1.08219001
65NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06517977
66BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05439416
67AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04689642
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03265244
69EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03172901
70VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98546032
71IGF1R_20145208_ChIP-Seq_DFB_Human0.96661788
72SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.95793592
73SPI1_23127762_ChIP-Seq_K562_Human0.95441793
74GATA1_26923725_Chip-Seq_HPCs_Mouse0.94545716
75PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93319274
76PRDM14_20953172_ChIP-Seq_ESCs_Human0.91985746
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91041438
78MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90724080
79OCT4_19829295_ChIP-Seq_ESCs_Human0.90342946
80ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90288716
81TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.86532356
82ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.84168830
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.83395626
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82711776
85TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82382314
86STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.82246753
87SA1_27219007_Chip-Seq_Bcells_Human0.82048175
88TP53_20018659_ChIP-ChIP_R1E_Mouse0.82044543
89UTX_26944678_Chip-Seq_JUKART_Human0.78955587
90ER_23166858_ChIP-Seq_MCF-7_Human0.78796540
91EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.78412702
92TCF4_18268006_ChIP-ChIP_LS174T_Human0.77243274
93EZH2_27294783_Chip-Seq_NPCs_Mouse0.76473527
94SMAD3_21741376_ChIP-Seq_HESCs_Human0.75992145
95RAC3_21632823_ChIP-Seq_H3396_Human0.74887366
96CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74438387
97RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.73766218
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.73598945
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.73044735
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73044735

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue6.13458374
2MP0006054_spinal_hemorrhage5.10942486
3MP0002837_dystrophic_cardiac_calcinosis3.99270341
4MP0004145_abnormal_muscle_electrophysio3.90302931
5MP0005623_abnormal_meninges_morphology2.93699782
6MP0002933_joint_inflammation2.85939201
7MP0004130_abnormal_muscle_cell2.81969657
8MP0006292_abnormal_olfactory_placode2.66698778
9MP0003195_calcinosis2.64937447
10MP0001661_extended_life_span2.54298824
11MP0005503_abnormal_tendon_morphology2.47103157
12MP0002277_abnormal_respiratory_mucosa2.46974303
13MP0002653_abnormal_ependyma_morphology2.46738772
14MP0003279_aneurysm2.28609522
15MP0004084_abnormal_cardiac_muscle2.28183304
16MP0009379_abnormal_foot_pigmentation2.15421075
17MP0005410_abnormal_fertilization2.00709416
18MP0008260_abnormal_autophagy1.95307447
19MP0000462_abnormal_digestive_system1.88354919
20MP0010155_abnormal_intestine_physiology1.72347915
21MP0005197_abnormal_uvea_morphology1.70721864
22MP0005000_abnormal_immune_tolerance1.67343932
23MP0001986_abnormal_taste_sensitivity1.64184073
24MP0010386_abnormal_urinary_bladder1.62151240
25MP0003436_decreased_susceptibility_to1.58241220
26MP0004036_abnormal_muscle_relaxation1.53930351
27MP0006082_CNS_inflammation1.52208059
28MP0001800_abnormal_humoral_immune1.51360554
29MP0004215_abnormal_myocardial_fiber1.48021396
30MP0002876_abnormal_thyroid_physiology1.46972984
31MP0002148_abnormal_hypersensitivity_rea1.44062606
32MP0006035_abnormal_mitochondrial_morpho1.43937622
33MP0001851_eye_inflammation1.42085524
34MP0005671_abnormal_response_to1.41719975
35MP0009250_abnormal_appendicular_skeleto1.39286863
36MP0000534_abnormal_ureter_morphology1.34969994
37MP0004185_abnormal_adipocyte_glucose1.33810491
38MP0009333_abnormal_splenocyte_physiolog1.27268342
39MP0003011_delayed_dark_adaptation1.27205709
40MP0002723_abnormal_immune_serum1.24620856
41MP0004484_altered_response_of1.20924930
42MP0002822_catalepsy1.16435346
43MP0002163_abnormal_gland_morphology1.14943534
44MP0002419_abnormal_innate_immunity1.14469832
45MP0005025_abnormal_response_to1.14195084
46MP0001727_abnormal_embryo_implantation1.12198475
47MP0009046_muscle_twitch1.09725325
48MP0005448_abnormal_energy_balance1.09339743
49MP0003724_increased_susceptibility_to1.07454762
50MP0004142_abnormal_muscle_tone1.07371182
51MP0002108_abnormal_muscle_morphology1.05893263
52MP0001845_abnormal_inflammatory_respons1.05721579
53MP0005253_abnormal_eye_physiology1.04906406
54MP0004947_skin_inflammation1.03909900
55MP0009785_altered_susceptibility_to1.01958799
56MP0002971_abnormal_brown_adipose0.98455623
57MP0000767_abnormal_smooth_muscle0.97452458
58MP0005423_abnormal_somatic_nervous0.96355597
59MP0000579_abnormal_nail_morphology0.94932179
60MP0002733_abnormal_thermal_nociception0.94187429
61MP0001835_abnormal_antigen_presentation0.92700764
62MP0001915_intracranial_hemorrhage0.91433916
63MP0002452_abnormal_antigen_presenting0.88426462
64MP0001905_abnormal_dopamine_level0.88305891
65MP0002735_abnormal_chemical_nociception0.88218399
66MP0002115_abnormal_skeleton_extremities0.87242364
67MP0000372_irregular_coat_pigmentation0.86497774
68MP0004147_increased_porphyrin_level0.86020268
69MP0005193_abnormal_anterior_eye0.85999656
70MP0005083_abnormal_biliary_tract0.85081601
71MP0001790_abnormal_immune_system0.83422147
72MP0005387_immune_system_phenotype0.83422147
73MP0002160_abnormal_reproductive_system0.82580283
74MP0006276_abnormal_autonomic_nervous0.81302508
75MP0008569_lethality_at_weaning0.78645696
76MP0000858_altered_metastatic_potential0.76940350
77MP0008775_abnormal_heart_ventricle0.75483908
78MP0000678_abnormal_parathyroid_gland0.73741487
79MP0005369_muscle_phenotype0.72993667
80MP0003866_abnormal_defecation0.72799872
81MP0002106_abnormal_muscle_physiology0.72118651
82MP0001970_abnormal_pain_threshold0.70029388
83MP0000230_abnormal_systemic_arterial0.69565891
84MP0003448_altered_tumor_morphology0.68552019
85MP0005645_abnormal_hypothalamus_physiol0.66046052
86MP0009765_abnormal_xenobiotic_induced0.65838496
87MP0005595_abnormal_vascular_smooth0.65424605
88MP0004885_abnormal_endolymph0.65269990
89MP0000920_abnormal_myelination0.64047055
90MP0009764_decreased_sensitivity_to0.63790332
91MP0001819_abnormal_immune_cell0.63696362
92MP0009745_abnormal_behavioral_response0.63683529
93MP0002420_abnormal_adaptive_immunity0.63439058
94MP0008872_abnormal_physiological_respon0.63317345
95MP0005386_behavior/neurological_phenoty0.62714731
96MP0004924_abnormal_behavior0.62714731
97MP0002722_abnormal_immune_system0.62679532
98MP0003137_abnormal_impulse_conducting0.61063532
99MP0008469_abnormal_protein_level0.60127373
100MP0003635_abnormal_synaptic_transmissio0.59829305

Predicted human phenotypes

RankGene SetZ-score
1Recurrent gram-negative bacterial infections (HP:0005420)7.92505250
2Periodontitis (HP:0000704)5.68220714
3Premature ovarian failure (HP:0008209)5.02081112
4Chronic hepatic failure (HP:0100626)4.60339161
5Cerebral hypomyelination (HP:0006808)4.40287974
6Recurrent abscess formation (HP:0002722)4.07191589
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.87334167
8Personality changes (HP:0000751)3.80101224
9Agitation (HP:0000713)3.75589861
10Gingivitis (HP:0000230)3.74232301
11Leukocytosis (HP:0001974)3.62311581
12Aplasia/Hypoplasia of the sacrum (HP:0008517)3.36591833
13Sparse scalp hair (HP:0002209)3.24046475
14Chronic bronchitis (HP:0004469)3.19239480
15Mutism (HP:0002300)3.16720707
16Nasal speech (HP:0001611)3.05823740
17Abnormality of the intervertebral disk (HP:0005108)3.04103058
18Dynein arm defect of respiratory motile cilia (HP:0012255)2.99663645
19Absent/shortened dynein arms (HP:0200106)2.99663645
20Abnormal respiratory motile cilium physiology (HP:0012261)2.97902421
21Delayed epiphyseal ossification (HP:0002663)2.96594905
22Rhinitis (HP:0012384)2.96195983
23Concave nail (HP:0001598)2.95736971
24Delusions (HP:0000746)2.90181817
25Dyskinesia (HP:0100660)2.74854861
26Restlessness (HP:0000711)2.64932587
27Aplasia of the musculature (HP:0100854)2.64303919
28Sudden death (HP:0001699)2.63434731
29Submucous cleft hard palate (HP:0000176)2.62607182
30Oral leukoplakia (HP:0002745)2.58190832
31Short femoral neck (HP:0100864)2.55014487
32Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.53288230
33Status epilepticus (HP:0002133)2.50503252
34Maternal diabetes (HP:0009800)2.46300685
35Abnormal number of erythroid precursors (HP:0012131)2.45424190
36Elevated erythrocyte sedimentation rate (HP:0003565)2.44685324
37Hypergonadotropic hypogonadism (HP:0000815)2.43721780
38Hemiplegia (HP:0002301)2.37968699
39Chronic otitis media (HP:0000389)2.37176593
40Alveolar cell carcinoma (HP:0006519)2.33277191
41Autoimmune thrombocytopenia (HP:0001973)2.32776743
42Absent phalangeal crease (HP:0006109)2.30042909
43Deep philtrum (HP:0002002)2.29351265
44Cupped ribs (HP:0000887)2.27158712
45Abnormality of T cell number (HP:0011839)2.26189674
46Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.25894981
47Progressive inability to walk (HP:0002505)2.25756279
48Synostosis of carpal bones (HP:0005048)2.20128294
49Glomerulonephritis (HP:0000099)2.17712418
50Genetic anticipation (HP:0003743)2.16948876
51Bony spicule pigmentary retinopathy (HP:0007737)2.11840321
52Abnormality of cells of the erythroid lineage (HP:0012130)2.11551448
53Ulnar deviation of the wrist (HP:0003049)2.09707210
54Optic neuritis (HP:0100653)2.06540555
55Retrobulbar optic neuritis (HP:0100654)2.06540555
56Keratoconus (HP:0000563)2.04762570
57Increased corneal curvature (HP:0100692)2.04762570
58Progressive cerebellar ataxia (HP:0002073)2.04673026
59Neoplasm of the tracheobronchial system (HP:0100552)2.01629354
60Small epiphyses (HP:0010585)2.00045389
61Systemic lupus erythematosus (HP:0002725)1.99390785
62Hypoplastic toenails (HP:0001800)1.98896727
63Reticulocytosis (HP:0001923)1.98892077
64Abnormal trabecular bone morphology (HP:0100671)1.96956192
65Memory impairment (HP:0002354)1.95782968
66Abnormality of reticulocytes (HP:0004312)1.94431392
67Tibial bowing (HP:0002982)1.94311378
68Secondary amenorrhea (HP:0000869)1.93851129
69Eosinophilia (HP:0001880)1.93382013
70Chronic sinusitis (HP:0011109)1.92707598
71Macrocytic anemia (HP:0001972)1.91659071
72Ileus (HP:0002595)1.91447433
73Asplenia (HP:0001746)1.91411537
74Pallor (HP:0000980)1.91081513
75Neonatal respiratory distress (HP:0002643)1.90611116
76Autoimmune hemolytic anemia (HP:0001890)1.90395121
77Abnormal ciliary motility (HP:0012262)1.86774879
78Hypoproteinemia (HP:0003075)1.86194898
79Hypercortisolism (HP:0001578)1.85524115
80Reticulocytopenia (HP:0001896)1.85014390
81Spinal cord compression (HP:0002176)1.83864877
82Abnormal finger flexion creases (HP:0006143)1.82566846
83Abnormal number of incisors (HP:0011064)1.82344839
84Abnormal delayed hypersensitivity skin test (HP:0002963)1.81175209
85Increased IgM level (HP:0003496)1.80341654
86Rough bone trabeculation (HP:0100670)1.79931174
87Unsteady gait (HP:0002317)1.79570474
88Focal seizures (HP:0007359)1.79315116
89Carpal synostosis (HP:0009702)1.79118344
90Abnormality of the phalanges of the 2nd finger (HP:0009541)1.78112225
91Aplasia/hypoplasia of the femur (HP:0005613)1.75780552
92IgM deficiency (HP:0002850)1.75775239
93Abnormal respiratory epithelium morphology (HP:0012253)1.75462750
94Abnormal respiratory motile cilium morphology (HP:0005938)1.75462750
95Aplasia/Hypoplasia of the spleen (HP:0010451)1.74563840
96Vasculitis (HP:0002633)1.72299991
97Hypoplasia of the uterus (HP:0000013)1.71522127
98Pulmonary embolism (HP:0002204)1.71502326
99Granulocytopenia (HP:0001913)1.71256015
100Abnormality of the fibula (HP:0002991)1.68067370

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK6.13018162
2MAP4K14.13969062
3PRKCI3.04227309
4BMPR22.87410967
5CAMKK12.82818436
6TXK2.62194929
7PBK2.20098471
8PRKCH2.14523992
9MAP3K132.00445758
10RIPK111.4803500
11PDPK11.77587744
12PRKCG1.36433165
13CSK1.27233424
14DAPK31.23301680
15FGR1.13840066
16PRKCD1.11746364
17TYRO31.08741364
18RIPK41.07552420
19YES11.03150265
20DAPK11.03028501
21MAPKAPK30.99636060
22EPHB10.96678705
23LCK0.94448273
24PRKCQ0.92289716
25PRKCE0.90889395
26PRKCZ0.83740652
27STK380.83505447
28LRRK20.79891775
29FES0.78096524
30NEK10.77396088
31SYK0.74857547
32JAK30.70175368
33FLT30.68113713
34ICK0.67049058
35STK40.65613683
36BTK0.63609315
37PTK60.55877022
38STK240.55326607
39ADRBK10.53984187
40CAMKK20.53880721
41FYN0.52887717
42INSRR0.52627513
43OBSCN0.51369702
44PRKCB0.49894712
45EPHA30.48963924
46ADRBK20.47265429
47SRC0.46461598
48MAP3K140.43010722
49MUSK0.41667527
50BRSK20.41456978
51IKBKB0.41205623
52JAK20.38035308
53NTRK30.36777659
54STK38L0.35990950
55SIK20.33742084
56MAP3K20.33254527
57MTOR0.32785429
58MAPK40.32706239
59TEC0.32627359
60PKN10.31562718
61GRK10.29823284
62ZAP700.29428481
63MAP4K20.27375186
64ITK0.26581939
65GRK70.26283052
66LYN0.25260050
67NTRK10.25205981
68FRK0.24996364
69CAMK2B0.24813995
70TRIB30.24475040
71PRKCA0.23930307
72TIE10.22637323
73EIF2AK30.21351151
74CAMK2A0.21253693
75MAPK150.20788301
76ERBB20.20713623
77KDR0.20228777
78WNK30.18181798
79MARK10.17792845
80WNK40.17030576
81RPS6KA30.16079366
82PRKACA0.15994898
83MAP3K70.15675260
84MAPK130.14639753
85IGF1R0.14391864
86PHKG10.13124279
87PHKG20.13124279
88PIK3CG0.12219746
89PTK20.12204845
90MAPK100.12020488
91DYRK20.11476476
92MAP3K80.11179502
93CAMK2G0.11075886
94TAOK30.11006657
95CSNK2A20.10404856
96MAP2K10.10332291
97CDK150.10226432
98NTRK20.09944014
99SGK10.09922702
100PDK10.09311977

Predicted pathways (KEGG)

RankGene SetZ-score
1Tyrosine metabolism_Homo sapiens_hsa003504.31341082
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.14973092
3Graft-versus-host disease_Homo sapiens_hsa053323.11901035
4Ribosome_Homo sapiens_hsa030102.82850230
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.68361035
6Staphylococcus aureus infection_Homo sapiens_hsa051502.59123360
7ErbB signaling pathway_Homo sapiens_hsa040122.37477734
8Acute myeloid leukemia_Homo sapiens_hsa052212.31856273
9Malaria_Homo sapiens_hsa051442.29362906
10Autoimmune thyroid disease_Homo sapiens_hsa053201.93202818
11Glycerolipid metabolism_Homo sapiens_hsa005611.84226058
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.82399148
13Sulfur relay system_Homo sapiens_hsa041221.80726202
14RNA polymerase_Homo sapiens_hsa030201.80455346
15Allograft rejection_Homo sapiens_hsa053301.77233234
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.75239589
17Type I diabetes mellitus_Homo sapiens_hsa049401.74254008
18Viral myocarditis_Homo sapiens_hsa054161.72066033
19mTOR signaling pathway_Homo sapiens_hsa041501.68131373
20Olfactory transduction_Homo sapiens_hsa047401.64827478
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.60281226
22Complement and coagulation cascades_Homo sapiens_hsa046101.53996625
23Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.42156047
24T cell receptor signaling pathway_Homo sapiens_hsa046601.41930020
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.37016147
26Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.35716389
27Rheumatoid arthritis_Homo sapiens_hsa053231.33432694
28Choline metabolism in cancer_Homo sapiens_hsa052311.32273247
29Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.31427782
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26306684
31Insulin resistance_Homo sapiens_hsa049311.24312405
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20488454
33Leishmaniasis_Homo sapiens_hsa051401.20126276
34Longevity regulating pathway - mammal_Homo sapiens_hsa042111.17689723
35Pertussis_Homo sapiens_hsa051331.16772323
36Legionellosis_Homo sapiens_hsa051341.12823780
37TGF-beta signaling pathway_Homo sapiens_hsa043501.04023186
38Regulation of autophagy_Homo sapiens_hsa041401.02082951
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00329395
40Antigen processing and presentation_Homo sapiens_hsa046120.95730973
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95016906
42Fat digestion and absorption_Homo sapiens_hsa049750.88819665
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85237296
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84854565
45Primary immunodeficiency_Homo sapiens_hsa053400.82536873
46Dorso-ventral axis formation_Homo sapiens_hsa043200.82529344
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80906557
48Glutathione metabolism_Homo sapiens_hsa004800.79895497
49African trypanosomiasis_Homo sapiens_hsa051430.72618898
50Insulin secretion_Homo sapiens_hsa049110.70881542
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70415141
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69107370
53Measles_Homo sapiens_hsa051620.68469964
54Linoleic acid metabolism_Homo sapiens_hsa005910.66320865
55Lysine degradation_Homo sapiens_hsa003100.65716891
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.63655326
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.63582821
58Salivary secretion_Homo sapiens_hsa049700.62547562
59Cardiac muscle contraction_Homo sapiens_hsa042600.61396535
60Amoebiasis_Homo sapiens_hsa051460.61346244
61HIF-1 signaling pathway_Homo sapiens_hsa040660.60624160
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59562944
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59308567
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.58986378
65Protein digestion and absorption_Homo sapiens_hsa049740.58323277
66Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57808773
67Asthma_Homo sapiens_hsa053100.57548286
68Type II diabetes mellitus_Homo sapiens_hsa049300.57355098
69Fatty acid metabolism_Homo sapiens_hsa012120.56783218
70Long-term potentiation_Homo sapiens_hsa047200.55735439
71PPAR signaling pathway_Homo sapiens_hsa033200.55511172
72Chemical carcinogenesis_Homo sapiens_hsa052040.55208873
73Axon guidance_Homo sapiens_hsa043600.54880388
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.54102763
75Taste transduction_Homo sapiens_hsa047420.49303630
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47161379
77TNF signaling pathway_Homo sapiens_hsa046680.45787434
78Tight junction_Homo sapiens_hsa045300.45511872
79Hematopoietic cell lineage_Homo sapiens_hsa046400.44083106
80Nicotine addiction_Homo sapiens_hsa050330.42759354
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42086881
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.40396256
83Rap1 signaling pathway_Homo sapiens_hsa040150.39531908
84Pancreatic secretion_Homo sapiens_hsa049720.39064030
85Chemokine signaling pathway_Homo sapiens_hsa040620.37726898
86Tuberculosis_Homo sapiens_hsa051520.37541350
87Phototransduction_Homo sapiens_hsa047440.37084922
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36703409
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36375167
90Mineral absorption_Homo sapiens_hsa049780.36289872
91Purine metabolism_Homo sapiens_hsa002300.35716844
92Insulin signaling pathway_Homo sapiens_hsa049100.35649322
93PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34940452
94B cell receptor signaling pathway_Homo sapiens_hsa046620.33392439
95RNA degradation_Homo sapiens_hsa030180.33368421
96Gastric acid secretion_Homo sapiens_hsa049710.32676416
97Serotonergic synapse_Homo sapiens_hsa047260.32432710
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32004765
99Amphetamine addiction_Homo sapiens_hsa050310.29459072
100Nitrogen metabolism_Homo sapiens_hsa009100.29281172

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