RPL4P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of 5.8S rRNA (GO:0000460)6.11419442
2viral transcription (GO:0019083)5.35096875
3translational termination (GO:0006415)5.20379105
4ribosomal small subunit assembly (GO:0000028)5.00875394
5establishment of protein localization to mitochondrial membrane (GO:0090151)4.98008774
6DNA deamination (GO:0045006)4.89091091
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.78755517
8tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.73935679
9RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.73935679
10cotranslational protein targeting to membrane (GO:0006613)4.68878345
11protein targeting to ER (GO:0045047)4.68692824
12ribosomal large subunit biogenesis (GO:0042273)4.50610274
13ribosomal small subunit biogenesis (GO:0042274)4.46615542
14establishment of protein localization to endoplasmic reticulum (GO:0072599)4.46126105
15protein localization to endoplasmic reticulum (GO:0070972)4.45860955
16translational elongation (GO:0006414)4.42166509
17maturation of SSU-rRNA (GO:0030490)4.37627133
18ATP synthesis coupled proton transport (GO:0015986)4.37604161
19energy coupled proton transport, down electrochemical gradient (GO:0015985)4.37604161
20GTP biosynthetic process (GO:0006183)4.29556882
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.26604534
22negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 4.17425439
23translational initiation (GO:0006413)4.04289698
24protein complex biogenesis (GO:0070271)4.03711879
25signal peptide processing (GO:0006465)3.99142346
26cytochrome complex assembly (GO:0017004)3.97480407
27nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.95472648
28chaperone-mediated protein transport (GO:0072321)3.92341107
29translation (GO:0006412)3.87262304
30viral life cycle (GO:0019058)3.86176816
31rRNA modification (GO:0000154)3.83210846
32cellular protein complex disassembly (GO:0043624)3.81627270
33positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)3.76905138
34mitochondrial respiratory chain complex assembly (GO:0033108)3.72694456
35cellular response to interferon-beta (GO:0035458)3.71148751
36regulation of mitochondrial translation (GO:0070129)3.67938966
37UTP biosynthetic process (GO:0006228)3.67873966
38pseudouridine synthesis (GO:0001522)3.60404315
39exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.54903794
40nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.53210417
41pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.49501100
42regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3.41239447
43UTP metabolic process (GO:0046051)3.37581524
44respiratory electron transport chain (GO:0022904)3.35853440
45electron transport chain (GO:0022900)3.31916017
46pyrimidine nucleotide catabolic process (GO:0006244)3.28145667
47negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.26732106
48mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.22442982
49nuclear-transcribed mRNA catabolic process (GO:0000956)3.15214176
50protein neddylation (GO:0045116)3.14346912
51protein complex disassembly (GO:0043241)3.14030098
52secretory granule organization (GO:0033363)3.13743034
53cullin deneddylation (GO:0010388)3.13524821
54respiratory chain complex IV assembly (GO:0008535)3.10550980
55protein targeting to membrane (GO:0006612)3.09563125
56cellular component biogenesis (GO:0044085)3.09107078
57rRNA processing (GO:0006364)3.08205795
58mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.07915934
59mitochondrial respiratory chain complex I assembly (GO:0032981)3.07915934
60NADH dehydrogenase complex assembly (GO:0010257)3.07915934
61guanosine-containing compound biosynthetic process (GO:1901070)3.05037011
62RNA localization (GO:0006403)3.02805457
63rRNA metabolic process (GO:0016072)3.02431675
64purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.02229874
65macromolecular complex disassembly (GO:0032984)2.99593912
66purine nucleoside triphosphate biosynthetic process (GO:0009145)2.98297487
67protein deneddylation (GO:0000338)2.95959727
68rRNA methylation (GO:0031167)2.95771273
69mRNA catabolic process (GO:0006402)2.94683447
70megakaryocyte development (GO:0035855)2.93524686
71proteasome assembly (GO:0043248)2.90464813
72ubiquinone biosynthetic process (GO:0006744)2.89539375
73regulation of translation in response to stress (GO:0043555)2.89116866
74negative regulation of translational initiation (GO:0045947)2.89036216
75CTP biosynthetic process (GO:0006241)2.88164832
76CTP metabolic process (GO:0046036)2.88164832
77signal complex assembly (GO:0007172)2.87891199
78nucleotide transmembrane transport (GO:1901679)2.86972054
79inner mitochondrial membrane organization (GO:0007007)2.85942260
80formation of translation preinitiation complex (GO:0001731)2.84935381
81RNA catabolic process (GO:0006401)2.84645271
82response to interferon-beta (GO:0035456)2.83269043
83ribonucleoprotein complex biogenesis (GO:0022613)2.81343203
84regulation of regulatory T cell differentiation (GO:0045589)2.80430757
85piRNA metabolic process (GO:0034587)2.79047016
86positive regulation of translational initiation (GO:0045948)2.78802600
87positive regulation of signal transduction by p53 class mediator (GO:1901798)2.78769807
88peptidyl-histidine modification (GO:0018202)2.78197000
89valine metabolic process (GO:0006573)2.76583903
90regulation of isotype switching to IgG isotypes (GO:0048302)2.76521031
91DNA catabolic process, exonucleolytic (GO:0000738)2.73750477
92regulation of B cell differentiation (GO:0045577)2.70579567
93pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.67400844
94regulation of cellular amino acid metabolic process (GO:0006521)2.65227249
95pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.62924040
96ATP biosynthetic process (GO:0006754)2.62021345
97base-excision repair, AP site formation (GO:0006285)2.61157113
98regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.60042194
99intracellular protein transmembrane import (GO:0044743)2.59273738
100tRNA processing (GO:0008033)2.58864060

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.44159720
2ELF1_17652178_ChIP-ChIP_JURKAT_Human4.44713319
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.42097950
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.17868679
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.01399750
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.48226715
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.11847186
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.87590666
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.78454874
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.76214971
11VDR_23849224_ChIP-Seq_CD4+_Human2.75998489
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.67473761
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.63925139
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.60029978
15VDR_22108803_ChIP-Seq_LS180_Human2.48481202
16FOXP3_21729870_ChIP-Seq_TREG_Human2.37566660
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.16879752
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.13938281
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.11398504
20ZNF274_21170338_ChIP-Seq_K562_Hela2.07360595
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.06245941
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.03150140
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.00613464
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.93611106
25ELK1_19687146_ChIP-ChIP_HELA_Human1.93299068
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.88190032
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.71495573
28YY1_21170310_ChIP-Seq_MESCs_Mouse1.70822922
29IGF1R_20145208_ChIP-Seq_DFB_Human1.63026975
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.61490361
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57251887
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.51088318
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.50895758
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50233635
35TTF2_22483619_ChIP-Seq_HELA_Human1.49878505
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.49202427
37MYC_18940864_ChIP-ChIP_HL60_Human1.45275605
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38660542
39POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38486469
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.34885928
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.34396805
42GABP_19822575_ChIP-Seq_HepG2_Human1.34089462
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33425227
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28934919
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28313374
46DCP1A_22483619_ChIP-Seq_HELA_Human1.28257663
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26193581
48MYB_26560356_Chip-Seq_TH2_Human1.25482232
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23458434
50MYC_19030024_ChIP-ChIP_MESCs_Mouse1.22931987
51GATA3_26560356_Chip-Seq_TH2_Human1.21988545
52TP53_22573176_ChIP-Seq_HFKS_Human1.21836933
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21771717
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21396238
55XRN2_22483619_ChIP-Seq_HELA_Human1.20898243
56FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19955565
57FOXA1_25329375_ChIP-Seq_VCAP_Human1.19955565
58NANOG_20526341_ChIP-Seq_ESCs_Human1.19741208
59EWS_26573619_Chip-Seq_HEK293_Human1.18215619
60SPI1_23547873_ChIP-Seq_NB4_Human1.17076048
61IRF8_21731497_ChIP-ChIP_J774_Mouse1.11997022
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.09248156
63AR_20517297_ChIP-Seq_VCAP_Human1.07113344
64NANOG_19829295_ChIP-Seq_ESCs_Human1.05440723
65SOX2_19829295_ChIP-Seq_ESCs_Human1.05440723
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05347307
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05145392
68FOXH1_21741376_ChIP-Seq_EPCs_Human1.03237033
69AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02955036
70PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.02610482
71FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01947616
72IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01857333
73EZH2_22144423_ChIP-Seq_EOC_Human1.00586800
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99786185
75E2F4_17652178_ChIP-ChIP_JURKAT_Human0.99288331
76FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.98503258
77STAT4_19710469_ChIP-ChIP_TH1__Mouse0.98443869
78PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.98240342
79ERG_20517297_ChIP-Seq_VCAP_Human0.97993060
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97078271
81CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96933482
82TAF2_19829295_ChIP-Seq_ESCs_Human0.96855102
83THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93169083
84KDM5A_27292631_Chip-Seq_BREAST_Human0.92392102
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90788991
86YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90114053
87ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89878632
88RUNX_20019798_ChIP-Seq_JUKART_Human0.88021539
89PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.87225172
90GATA3_21878914_ChIP-Seq_MCF-7_Human0.86575874
91NCOR_22424771_ChIP-Seq_293T_Human0.86247985
92ELK1_22589737_ChIP-Seq_MCF10A_Human0.86044215
93YY1_22570637_ChIP-Seq_MALME-3M_Human0.85996309
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.85423162
95EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.84459759
96NFE2_27457419_Chip-Seq_LIVER_Mouse0.83175649
97CIITA_25753668_ChIP-Seq_RAJI_Human0.82910308
98FOXA1_21572438_ChIP-Seq_LNCaP_Human0.82842249
99CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.82309979
100SUZ12_27294783_Chip-Seq_NPCs_Mouse0.82147911

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.78160562
2MP0001835_abnormal_antigen_presentation3.41135726
3MP0003646_muscle_fatigue3.40767307
4MP0005671_abnormal_response_to3.29396210
5MP0008877_abnormal_DNA_methylation2.67382984
6MP0000685_abnormal_immune_system2.57193986
7MP0004145_abnormal_muscle_electrophysio2.56229302
8MP0004147_increased_porphyrin_level2.38807865
9MP0005387_immune_system_phenotype2.20916367
10MP0001790_abnormal_immune_system2.20916367
11MP0001800_abnormal_humoral_immune2.20702394
12MP0001873_stomach_inflammation2.17417852
13MP0002163_abnormal_gland_morphology2.14391226
14MP0009333_abnormal_splenocyte_physiolog2.10251492
15MP0006292_abnormal_olfactory_placode2.05392821
16MP0005645_abnormal_hypothalamus_physiol2.05187330
17MP0000372_irregular_coat_pigmentation2.02500981
18MP0008058_abnormal_DNA_repair2.00464955
19MP0002148_abnormal_hypersensitivity_rea1.92037802
20MP0009785_altered_susceptibility_to1.90739312
21MP0002138_abnormal_hepatobiliary_system1.90069787
22MP0009764_decreased_sensitivity_to1.88478964
23MP0005000_abnormal_immune_tolerance1.83401011
24MP0004142_abnormal_muscle_tone1.79762672
25MP0005075_abnormal_melanosome_morpholog1.79294528
26MP0002277_abnormal_respiratory_mucosa1.71302991
27MP0002837_dystrophic_cardiac_calcinosis1.69706254
28MP0008875_abnormal_xenobiotic_pharmacok1.69425121
29MP0003186_abnormal_redox_activity1.68765089
30MP0008995_early_reproductive_senescence1.62084735
31MP0002723_abnormal_immune_serum1.59373711
32MP0006035_abnormal_mitochondrial_morpho1.57030139
33MP0005084_abnormal_gallbladder_morpholo1.56674413
34MP0001986_abnormal_taste_sensitivity1.54068126
35MP0008872_abnormal_physiological_respon1.51389838
36MP0003195_calcinosis1.51257054
37MP0003123_paternal_imprinting1.46212875
38MP0003787_abnormal_imprinting1.45503132
39MP0002452_abnormal_antigen_presenting1.44092476
40MP0006036_abnormal_mitochondrial_physio1.41526981
41MP0002420_abnormal_adaptive_immunity1.41295515
42MP0003763_abnormal_thymus_physiology1.40356768
43MP0001819_abnormal_immune_cell1.39514710
44MP0003121_genomic_imprinting1.37687978
45MP0005410_abnormal_fertilization1.33591298
46MP0002102_abnormal_ear_morphology1.32483231
47MP0006072_abnormal_retinal_apoptosis1.30153783
48MP0005379_endocrine/exocrine_gland_phen1.28463895
49MP0003436_decreased_susceptibility_to1.25976454
50MP0003011_delayed_dark_adaptation1.24376607
51MP0002638_abnormal_pupillary_reflex1.16524612
52MP0002398_abnormal_bone_marrow1.15792722
53MP0005551_abnormal_eye_electrophysiolog1.15254412
54MP0000689_abnormal_spleen_morphology1.14437293
55MP0003718_maternal_effect1.12889524
56MP0010155_abnormal_intestine_physiology1.12217603
57MP0000716_abnormal_immune_system1.08766741
58MP0005025_abnormal_response_to1.06689073
59MP0003866_abnormal_defecation1.05796590
60MP0002876_abnormal_thyroid_physiology1.02653366
61MP0001968_abnormal_touch/_nociception1.01509218
62MP0005636_abnormal_mineral_homeostasis0.99885591
63MP0001845_abnormal_inflammatory_respons0.99594907
64MP0003786_premature_aging0.98971886
65MP0006276_abnormal_autonomic_nervous0.98382093
66MP0003122_maternal_imprinting0.97549172
67MP0002405_respiratory_system_inflammati0.97411146
68MP0009046_muscle_twitch0.95534951
69MP0009765_abnormal_xenobiotic_induced0.95081578
70MP0001663_abnormal_digestive_system0.92054277
71MP0004885_abnormal_endolymph0.91027007
72MP0002722_abnormal_immune_system0.89790865
73MP0002429_abnormal_blood_cell0.89509984
74MP0004043_abnormal_pH_regulation0.88840608
75MP0003567_abnormal_fetal_cardiomyocyte0.88439096
76MP0002272_abnormal_nervous_system0.87584023
77MP0000703_abnormal_thymus_morphology0.85901633
78MP0003724_increased_susceptibility_to0.83998121
79MP0002736_abnormal_nociception_after0.83751214
80MP0005377_hearing/vestibular/ear_phenot0.82117831
81MP0003878_abnormal_ear_physiology0.82117831
82MP0003806_abnormal_nucleotide_metabolis0.81752696
83MP0003252_abnormal_bile_duct0.80942659
84MP0001853_heart_inflammation0.80847757
85MP0002419_abnormal_innate_immunity0.75271460
86MP0005083_abnormal_biliary_tract0.73610053
87MP0005389_reproductive_system_phenotype0.72389253
88MP0008469_abnormal_protein_level0.71542742
89MP0001905_abnormal_dopamine_level0.71412142
90MP0000613_abnormal_salivary_gland0.69484858
91MP0002006_tumorigenesis0.67680536
92MP0002210_abnormal_sex_determination0.66427799
93MP0000049_abnormal_middle_ear0.64780748
94MP0002160_abnormal_reproductive_system0.64601770
95MP0005253_abnormal_eye_physiology0.64257497
96MP0005085_abnormal_gallbladder_physiolo0.63730297
97MP0003315_abnormal_perineum_morphology0.62871929
98MP0002733_abnormal_thermal_nociception0.60607500
99MP0002693_abnormal_pancreas_physiology0.60596675
100MP0001727_abnormal_embryo_implantation0.60537884

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)4.25295523
2Acute necrotizing encephalopathy (HP:0006965)4.09332038
3Abnormal rod and cone electroretinograms (HP:0008323)3.82066064
4Mitochondrial inheritance (HP:0001427)3.69899904
5Increased hepatocellular lipid droplets (HP:0006565)3.69857444
6Elevated erythrocyte sedimentation rate (HP:0003565)3.64845184
7Increased CSF lactate (HP:0002490)3.59786604
8Acute encephalopathy (HP:0006846)3.57438907
9Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.52031515
10Abnormality of alanine metabolism (HP:0010916)3.52031515
11Hyperalaninemia (HP:0003348)3.52031515
123-Methylglutaconic aciduria (HP:0003535)3.46219913
13Abnormal mitochondria in muscle tissue (HP:0008316)3.44186898
14Lipid accumulation in hepatocytes (HP:0006561)3.44003861
15Stomatitis (HP:0010280)3.34177742
16Progressive macrocephaly (HP:0004481)3.23887654
17Cerebral hypomyelination (HP:0006808)3.23551318
18IgG deficiency (HP:0004315)3.23479873
19Hepatocellular necrosis (HP:0001404)3.08425989
20Aplastic anemia (HP:0001915)3.05026038
21Congenital stationary night blindness (HP:0007642)2.91921509
22Hepatic necrosis (HP:0002605)2.83366669
23Macrocytic anemia (HP:0001972)2.79934701
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.76077919
25Cerebral edema (HP:0002181)2.71631443
26Renal Fanconi syndrome (HP:0001994)2.70538730
27Increased serum lactate (HP:0002151)2.69772728
28Abnormality of midbrain morphology (HP:0002418)2.69274782
29Molar tooth sign on MRI (HP:0002419)2.69274782
30Pendular nystagmus (HP:0012043)2.67488645
31Exertional dyspnea (HP:0002875)2.62789741
32Type 2 muscle fiber atrophy (HP:0003554)2.60894849
33IgM deficiency (HP:0002850)2.54582255
34Decreased central vision (HP:0007663)2.53968257
35Optic disc pallor (HP:0000543)2.51188074
36Pancreatic cysts (HP:0001737)2.46400447
37Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.44915731
38Dynein arm defect of respiratory motile cilia (HP:0012255)2.44067688
39Absent/shortened dynein arms (HP:0200106)2.44067688
40Congenital, generalized hypertrichosis (HP:0004540)2.37121422
41Lactic acidosis (HP:0003128)2.34735764
42Oral leukoplakia (HP:0002745)2.31349130
43Muscle fiber atrophy (HP:0100295)2.30202590
44True hermaphroditism (HP:0010459)2.30027349
45Pallor (HP:0000980)2.28684638
46Increased intramyocellular lipid droplets (HP:0012240)2.26288344
47Nephronophthisis (HP:0000090)2.23144299
48Increased IgM level (HP:0003496)2.21758244
49Asplenia (HP:0001746)2.20380134
50Optic neuritis (HP:0100653)2.19558309
51Retrobulbar optic neuritis (HP:0100654)2.19558309
52Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.18678894
53Decreased activity of mitochondrial respiratory chain (HP:0008972)2.18678894
54Abnormality of T cells (HP:0002843)2.18588158
55Attenuation of retinal blood vessels (HP:0007843)2.18346188
56Aplasia/Hypoplasia of the spleen (HP:0010451)2.17795993
57Carpal bone hypoplasia (HP:0001498)2.17708348
58Pancreatic fibrosis (HP:0100732)2.17101175
59Abnormal biliary tract physiology (HP:0012439)2.17068645
60Bile duct proliferation (HP:0001408)2.17068645
61Abolished electroretinogram (ERG) (HP:0000550)2.10077607
62Increased corneal curvature (HP:0100692)2.09085332
63Keratoconus (HP:0000563)2.09085332
64Encephalitis (HP:0002383)2.08882857
65Respiratory difficulties (HP:0002880)2.07644238
66Reticulocytopenia (HP:0001896)2.04354373
67Abnormality of T cell physiology (HP:0011840)2.02569688
68Abnormality of the prostate (HP:0008775)2.01884856
69Lethargy (HP:0001254)2.00197169
70Vasculitis (HP:0002633)1.96899442
71Abnormality of cells of the erythroid lineage (HP:0012130)1.96580681
72Agitation (HP:0000713)1.95565015
73Emotional lability (HP:0000712)1.94211578
74CNS demyelination (HP:0007305)1.92458563
75Hypoproteinemia (HP:0003075)1.91832570
76Optic nerve coloboma (HP:0000588)1.90209870
77Respiratory failure (HP:0002878)1.89333749
78Increased muscle lipid content (HP:0009058)1.88963560
79Hyperphosphaturia (HP:0003109)1.85853941
80Leukodystrophy (HP:0002415)1.85466455
81Testicular atrophy (HP:0000029)1.84165162
82Abnormal number of erythroid precursors (HP:0012131)1.83680182
83Renal cortical cysts (HP:0000803)1.83350700
84Abnormality of the renal medulla (HP:0100957)1.83132206
85Pancytopenia (HP:0001876)1.82089304
86Abnormality of urine glucose concentration (HP:0011016)1.81226357
87Glycosuria (HP:0003076)1.81226357
88Acute hepatic failure (HP:0006554)1.78203104
89Microretrognathia (HP:0000308)1.76913095
90Methylmalonic acidemia (HP:0002912)1.76345644
91Panhypogammaglobulinemia (HP:0003139)1.75972843
92CNS hypomyelination (HP:0003429)1.74971713
93T lymphocytopenia (HP:0005403)1.72311388
94Male pseudohermaphroditism (HP:0000037)1.72010830
95Cleft eyelid (HP:0000625)1.70574310
96Recurrent sinusitis (HP:0011108)1.70544818
97Type II lissencephaly (HP:0007260)1.69769860
98Recurrent cutaneous fungal infections (HP:0011370)1.69541321
99Chronic mucocutaneous candidiasis (HP:0002728)1.69541321
100Abnormality of the renal cortex (HP:0011035)1.69340536

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.04255801
2BMPR23.95904709
3RIPK13.53939050
4TXK2.95765443
5MAP4K12.95414681
6EIF2AK32.93029227
7VRK22.60074832
8RIPK42.48311948
9WNK42.40260200
10PASK2.30732375
11NME22.08168251
12EIF2AK11.96252282
13PRKCI1.95049269
14TSSK61.87338780
15ARAF1.78196369
16CDK191.77269975
17NUAK11.72323599
18TLK11.69307353
19ADRBK21.65892235
20TRIM281.65468769
21NME11.65018991
22TAOK31.56052905
23TEC1.54979790
24INSRR1.41952853
25STK161.40490069
26WNK31.38582894
27GRK11.37804544
28GRK61.37654030
29ITK1.37013454
30TAF11.36487238
31NEK11.32929199
32BCKDK1.32323114
33MST41.31317545
34SYK1.28838733
35PIM21.24371329
36OXSR11.24118987
37PDK21.23393707
38BTK1.21173664
39PINK11.10101721
40IKBKB1.07045383
41KIT1.06712050
42PRKCG1.04319839
43VRK11.04029955
44DAPK30.98704007
45PLK40.96694654
46SRPK10.94923199
47DYRK20.92490352
48STK390.86171588
49PRKCE0.82404231
50LCK0.81620358
51CDK80.81012227
52RPS6KA50.78295373
53LYN0.77026876
54MAP2K60.70777651
55ZAK0.67155803
56FLT30.66151496
57EIF2AK20.65252683
58PRKCQ0.64726148
59IKBKE0.63688070
60MATK0.63669063
61JAK30.60783606
62CSK0.60320189
63CSNK2A20.58992015
64TIE10.58144074
65KDR0.56604769
66DAPK10.55335743
67DAPK20.54852765
68PRKCD0.53132906
69PLK30.50055203
70PLK20.49911494
71PTK2B0.47971749
72RPS6KA40.47176922
73CSNK2A10.46398555
74FRK0.46330526
75STK38L0.45264194
76TYK20.42288652
77CAMKK10.42084835
78PHKG20.41629419
79PHKG10.41629419
80BUB10.41122100
81HCK0.38475158
82LRRK20.37088328
83RPS6KA60.36510475
84ATR0.36020275
85OBSCN0.35706355
86CSNK1G30.34820081
87GRK50.34669358
88ADRBK10.34367804
89STK40.33726752
90IGF1R0.33435459
91PRKCZ0.33380773
92PRKACA0.32886727
93PRKCB0.32591092
94PDPK10.32388891
95PRKCA0.31319455
96WNK10.31063360
97MAP3K40.30250296
98FGR0.29058259
99PIM10.28603599
100ILK0.28029923

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.96476041
2Proteasome_Homo sapiens_hsa030503.64621767
3Oxidative phosphorylation_Homo sapiens_hsa001903.32835992
4Asthma_Homo sapiens_hsa053103.08908673
5Protein export_Homo sapiens_hsa030603.04960495
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.01559786
7Parkinsons disease_Homo sapiens_hsa050122.82016580
8Allograft rejection_Homo sapiens_hsa053302.77639347
9Graft-versus-host disease_Homo sapiens_hsa053322.62635016
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.61172017
11Autoimmune thyroid disease_Homo sapiens_hsa053202.57500438
12Type I diabetes mellitus_Homo sapiens_hsa049402.35704407
13RNA degradation_Homo sapiens_hsa030182.22801395
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.22086402
15Primary immunodeficiency_Homo sapiens_hsa053402.19889345
16Huntingtons disease_Homo sapiens_hsa050161.90218691
17RNA polymerase_Homo sapiens_hsa030201.84895383
18Alzheimers disease_Homo sapiens_hsa050101.79379279
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67849701
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67074352
21Antigen processing and presentation_Homo sapiens_hsa046121.55385301
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.53041041
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.51457837
24Homologous recombination_Homo sapiens_hsa034401.50381446
25Linoleic acid metabolism_Homo sapiens_hsa005911.49032157
26Sulfur relay system_Homo sapiens_hsa041221.39702344
27Cardiac muscle contraction_Homo sapiens_hsa042601.39533360
28RNA transport_Homo sapiens_hsa030131.29777177
29Regulation of autophagy_Homo sapiens_hsa041401.24071648
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.22950706
31One carbon pool by folate_Homo sapiens_hsa006701.22870304
32Rheumatoid arthritis_Homo sapiens_hsa053231.20842291
33Pyrimidine metabolism_Homo sapiens_hsa002401.16975440
34Basal transcription factors_Homo sapiens_hsa030221.05895606
35Viral myocarditis_Homo sapiens_hsa054161.02124478
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96745839
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94047127
38Arachidonic acid metabolism_Homo sapiens_hsa005900.93135012
39DNA replication_Homo sapiens_hsa030300.91097598
40NF-kappa B signaling pathway_Homo sapiens_hsa040640.90968537
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.85980566
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82246577
43Hematopoietic cell lineage_Homo sapiens_hsa046400.82081095
44Spliceosome_Homo sapiens_hsa030400.81922248
45Mismatch repair_Homo sapiens_hsa034300.81819226
46Base excision repair_Homo sapiens_hsa034100.81691857
47Tyrosine metabolism_Homo sapiens_hsa003500.78979838
48Propanoate metabolism_Homo sapiens_hsa006400.78541501
49Nucleotide excision repair_Homo sapiens_hsa034200.77870102
50Purine metabolism_Homo sapiens_hsa002300.77403263
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77307878
52T cell receptor signaling pathway_Homo sapiens_hsa046600.76150486
53Phototransduction_Homo sapiens_hsa047440.74942411
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74725064
55Ether lipid metabolism_Homo sapiens_hsa005650.74688097
56Peroxisome_Homo sapiens_hsa041460.70351427
57Sulfur metabolism_Homo sapiens_hsa009200.66775654
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66604574
59Olfactory transduction_Homo sapiens_hsa047400.65682982
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62741455
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62683402
62Fanconi anemia pathway_Homo sapiens_hsa034600.62352342
63Caffeine metabolism_Homo sapiens_hsa002320.61027867
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58368156
65Tryptophan metabolism_Homo sapiens_hsa003800.57532562
66Non-homologous end-joining_Homo sapiens_hsa034500.57139343
67Metabolic pathways_Homo sapiens_hsa011000.55039483
68Staphylococcus aureus infection_Homo sapiens_hsa051500.53128160
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53034617
70Fat digestion and absorption_Homo sapiens_hsa049750.51244996
71Collecting duct acid secretion_Homo sapiens_hsa049660.47727411
72Chemical carcinogenesis_Homo sapiens_hsa052040.47693523
73Nitrogen metabolism_Homo sapiens_hsa009100.46659266
74Systemic lupus erythematosus_Homo sapiens_hsa053220.46372468
75Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46157129
76Butanoate metabolism_Homo sapiens_hsa006500.44513534
77Epstein-Barr virus infection_Homo sapiens_hsa051690.42833016
78Retinol metabolism_Homo sapiens_hsa008300.38912926
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.38193477
80Measles_Homo sapiens_hsa051620.37528180
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36533453
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36112983
83beta-Alanine metabolism_Homo sapiens_hsa004100.35988219
84African trypanosomiasis_Homo sapiens_hsa051430.35370362
85Leishmaniasis_Homo sapiens_hsa051400.35349921
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33644603
87Glutathione metabolism_Homo sapiens_hsa004800.32783772
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32290371
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31638288
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29190968
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.27895140
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26232768
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.25862811
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25851196
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25813712
96Herpes simplex infection_Homo sapiens_hsa051680.25486142
97Fatty acid degradation_Homo sapiens_hsa000710.21315077
98Morphine addiction_Homo sapiens_hsa050320.20655315
99Pyruvate metabolism_Homo sapiens_hsa006200.18984415
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.15776123

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