RPL4P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.35256758
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.50810569
3cytidine deamination (GO:0009972)6.41989180
4cytidine metabolic process (GO:0046087)6.41989180
5cytidine catabolic process (GO:0006216)6.41989180
6pyrimidine ribonucleoside catabolic process (GO:0046133)5.56527931
7ribosomal small subunit assembly (GO:0000028)5.37264807
8ATP synthesis coupled proton transport (GO:0015986)4.87552136
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.87552136
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.74198392
11regulation of regulatory T cell differentiation (GO:0045589)4.35442002
12viral transcription (GO:0019083)4.14093125
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.05690269
14establishment of protein localization to mitochondrial membrane (GO:0090151)4.01571727
15tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.98741346
16RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.98741346
17translational termination (GO:0006415)3.96169637
18respiratory electron transport chain (GO:0022904)3.77398974
19electron transport chain (GO:0022900)3.73740114
20translational elongation (GO:0006414)3.72902102
21SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.67205311
22proteasome assembly (GO:0043248)3.61887335
23protein targeting to ER (GO:0045047)3.58959873
24cotranslational protein targeting to membrane (GO:0006613)3.58707617
25protein complex biogenesis (GO:0070271)3.57916309
26protein neddylation (GO:0045116)3.54565237
27sequestering of actin monomers (GO:0042989)3.53194753
28maturation of SSU-rRNA (GO:0030490)3.51712497
29termination of RNA polymerase III transcription (GO:0006386)3.48895215
30transcription elongation from RNA polymerase III promoter (GO:0006385)3.48895215
31rRNA modification (GO:0000154)3.48291707
32behavioral response to nicotine (GO:0035095)3.45538304
33ribosomal large subunit biogenesis (GO:0042273)3.44357302
34protein localization to endoplasmic reticulum (GO:0070972)3.43543087
35establishment of protein localization to endoplasmic reticulum (GO:0072599)3.43255940
36mitochondrial respiratory chain complex I assembly (GO:0032981)3.42817174
37NADH dehydrogenase complex assembly (GO:0010257)3.42817174
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.42817174
39ribosomal small subunit biogenesis (GO:0042274)3.39605534
40mitochondrial respiratory chain complex assembly (GO:0033108)3.30792974
41pseudouridine synthesis (GO:0001522)3.22781891
42positive regulation of interleukin-8 secretion (GO:2000484)3.18451302
43translation (GO:0006412)3.17845508
44chaperone-mediated protein transport (GO:0072321)3.17103603
45metallo-sulfur cluster assembly (GO:0031163)3.13808540
46iron-sulfur cluster assembly (GO:0016226)3.13808540
47positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.11634117
48nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.11059825
49pyrimidine nucleoside catabolic process (GO:0046135)3.06931380
50water-soluble vitamin biosynthetic process (GO:0042364)3.04612866
51regulation of cellular amino acid metabolic process (GO:0006521)3.02692379
52purine nucleotide salvage (GO:0032261)3.01387473
53exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.99850677
54GTP biosynthetic process (GO:0006183)2.99203999
55translational initiation (GO:0006413)2.98926444
56DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.97143257
57cellular component biogenesis (GO:0044085)2.96506040
58pyrimidine ribonucleoside metabolic process (GO:0046131)2.95016050
59platelet dense granule organization (GO:0060155)2.94464032
60negative regulation by host of viral transcription (GO:0043922)2.94222417
61purine nucleoside triphosphate biosynthetic process (GO:0009145)2.94149338
62preassembly of GPI anchor in ER membrane (GO:0016254)2.93826586
63regulation of isotype switching to IgG isotypes (GO:0048302)2.93543764
64positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.92077350
65viral life cycle (GO:0019058)2.91718561
66purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.91543924
67negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.89443198
68ATP biosynthetic process (GO:0006754)2.89124952
69ribonucleoprotein complex biogenesis (GO:0022613)2.88545523
70signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.88362108
71signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.88362108
72signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.88362108
73cellular protein complex disassembly (GO:0043624)2.85792128
74positive regulation of T cell apoptotic process (GO:0070234)2.85074706
75signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.84807710
76intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.84807710
77regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.83399750
78positive regulation of interleukin-17 production (GO:0032740)2.82496062
79nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.80550878
80peptidyl-histidine modification (GO:0018202)2.80539231
81negative regulation of T cell apoptotic process (GO:0070233)2.79068252
82mannosylation (GO:0097502)2.78757166
83ubiquinone biosynthetic process (GO:0006744)2.74052399
84rRNA processing (GO:0006364)2.73337719
85rRNA methylation (GO:0031167)2.72814050
86hydrogen ion transmembrane transport (GO:1902600)2.72755090
87signal transduction involved in DNA integrity checkpoint (GO:0072401)2.72057230
88signal transduction involved in DNA damage checkpoint (GO:0072422)2.72057230
89pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.72023595
90respiratory chain complex IV assembly (GO:0008535)2.70566673
91regulation of interleukin-8 secretion (GO:2000482)2.68654158
92intracellular protein transmembrane import (GO:0044743)2.68612535
93signal transduction involved in cell cycle checkpoint (GO:0072395)2.67879353
94antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.66027976
95rRNA metabolic process (GO:0016072)2.65792986
96positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.63710234
97protein-cofactor linkage (GO:0018065)2.62232241
98positive regulation of tolerance induction (GO:0002645)2.62075104
99negative regulation of calcium ion transport into cytosol (GO:0010523)2.58018164
100L-fucose metabolic process (GO:0042354)2.57924280

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.65467906
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.94772149
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.89236004
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.65209152
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.51969692
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.39576438
7VDR_22108803_ChIP-Seq_LS180_Human3.31954096
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.28885740
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.01931617
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.79320875
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.73997033
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.73173287
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.72053346
14VDR_23849224_ChIP-Seq_CD4+_Human2.59059926
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.20595535
16ZNF274_21170338_ChIP-Seq_K562_Hela2.13409252
17FOXP3_21729870_ChIP-Seq_TREG_Human2.11141255
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.03923201
19SRF_21415370_ChIP-Seq_HL-1_Mouse1.99495233
20MYC_18555785_ChIP-Seq_MESCs_Mouse1.92605285
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.91477057
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.78449466
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68659427
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.67721328
25ELK1_19687146_ChIP-ChIP_HELA_Human1.60362920
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.59365384
27MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59359730
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.53474466
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.49934368
30MYB_26560356_Chip-Seq_TH2_Human1.45831096
31MYC_18940864_ChIP-ChIP_HL60_Human1.43362752
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.42021813
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.41426477
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41340815
35PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.37612574
36GATA3_26560356_Chip-Seq_TH2_Human1.35270102
37FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34716083
38FOXA1_25329375_ChIP-Seq_VCAP_Human1.34716083
39TP53_22573176_ChIP-Seq_HFKS_Human1.34156640
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.34049650
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31309579
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30808201
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29166912
44RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.28750105
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27200167
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27111868
47NCOR_22424771_ChIP-Seq_293T_Human1.26897775
48AR_20517297_ChIP-Seq_VCAP_Human1.26148344
49GABP_19822575_ChIP-Seq_HepG2_Human1.25207118
50EWS_26573619_Chip-Seq_HEK293_Human1.25162576
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25031887
52AUTS2_25519132_ChIP-Seq_293T-REX_Human1.24743846
53NANOG_20526341_ChIP-Seq_ESCs_Human1.24565479
54EZH2_22144423_ChIP-Seq_EOC_Human1.21725543
55EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.20777248
56CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19454097
57IGF1R_20145208_ChIP-Seq_DFB_Human1.18678524
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18550446
59EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.18266296
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18215994
61TTF2_22483619_ChIP-Seq_HELA_Human1.17684732
62IRF8_21731497_ChIP-ChIP_J774_Mouse1.16440383
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14475494
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14412238
65CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12488735
66TAF2_19829295_ChIP-Seq_ESCs_Human1.12259555
67CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.11559249
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10996445
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09706434
70TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.08912280
71FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08344112
72PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08061272
73GATA3_27048872_Chip-Seq_THYMUS_Human1.07682578
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.06252999
75MYC_19829295_ChIP-Seq_ESCs_Human1.04928124
76ERA_21632823_ChIP-Seq_H3396_Human1.03332193
77XRN2_22483619_ChIP-Seq_HELA_Human1.02654112
78HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02132270
79HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.01996734
80FOXH1_21741376_ChIP-Seq_EPCs_Human1.01420068
81FUS_26573619_Chip-Seq_HEK293_Human1.01006515
82BCL6_27268052_Chip-Seq_Bcells_Human1.00947085
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00923404
84MYC_19030024_ChIP-ChIP_MESCs_Mouse1.00181592
85ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99591125
86STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99206466
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99203082
88ERG_20517297_ChIP-Seq_VCAP_Human0.98139946
89RUNX_20019798_ChIP-Seq_JUKART_Human0.97418344
90ELK1_22589737_ChIP-Seq_MCF10A_Human0.97059249
91FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95987598
92NANOG_19829295_ChIP-Seq_ESCs_Human0.95006489
93SOX2_19829295_ChIP-Seq_ESCs_Human0.95006489
94CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94961407
95P53_21459846_ChIP-Seq_SAOS-2_Human0.93880164
96HOXB7_26014856_ChIP-Seq_BT474_Human0.93565623
97CTCF_20526341_ChIP-Seq_ESCs_Human0.93273618
98FOXH1_21741376_ChIP-Seq_ESCs_Human0.92141795
99PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92040240
100GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91480647

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.19639816
2MP0005671_abnormal_response_to4.02042911
3MP0001835_abnormal_antigen_presentation3.04408392
4MP0009333_abnormal_splenocyte_physiolog2.45864592
5MP0009785_altered_susceptibility_to2.35083508
6MP0006292_abnormal_olfactory_placode2.32224947
7MP0002163_abnormal_gland_morphology2.21552796
8MP0004147_increased_porphyrin_level2.08577690
9MP0000685_abnormal_immune_system2.04581761
10MP0002102_abnormal_ear_morphology2.03525887
11MP0005646_abnormal_pituitary_gland1.92355049
12MP0002138_abnormal_hepatobiliary_system1.91452887
13MP0002148_abnormal_hypersensitivity_rea1.88803666
14MP0001800_abnormal_humoral_immune1.88163227
15MP0003806_abnormal_nucleotide_metabolis1.86456664
16MP0001986_abnormal_taste_sensitivity1.85282215
17MP0008872_abnormal_physiological_respon1.83642003
18MP0001790_abnormal_immune_system1.83470236
19MP0005387_immune_system_phenotype1.83470236
20MP0002837_dystrophic_cardiac_calcinosis1.80078931
21MP0005084_abnormal_gallbladder_morpholo1.77508233
22MP0005000_abnormal_immune_tolerance1.76925701
23MP0003763_abnormal_thymus_physiology1.73803260
24MP0003646_muscle_fatigue1.71597552
25MP0001188_hyperpigmentation1.70562789
26MP0001873_stomach_inflammation1.68741608
27MP0006072_abnormal_retinal_apoptosis1.59294745
28MP0005389_reproductive_system_phenotype1.57944862
29MP0005379_endocrine/exocrine_gland_phen1.57818447
30MP0002723_abnormal_immune_serum1.53132200
31MP0008058_abnormal_DNA_repair1.52993918
32MP0005360_urolithiasis1.52872941
33MP0002420_abnormal_adaptive_immunity1.50058762
34MP0003878_abnormal_ear_physiology1.49107965
35MP0005377_hearing/vestibular/ear_phenot1.49107965
36MP0005551_abnormal_eye_electrophysiolog1.47945436
37MP0001968_abnormal_touch/_nociception1.47739056
38MP0004145_abnormal_muscle_electrophysio1.46084837
39MP0005645_abnormal_hypothalamus_physiol1.45555583
40MP0000372_irregular_coat_pigmentation1.43314732
41MP0001819_abnormal_immune_cell1.43040090
42MP0002160_abnormal_reproductive_system1.40314648
43MP0005025_abnormal_response_to1.39934056
44MP0001919_abnormal_reproductive_system1.39146740
45MP0002006_tumorigenesis1.38182528
46MP0002166_altered_tumor_susceptibility1.33171466
47MP0002095_abnormal_skin_pigmentation1.33106803
48MP0005075_abnormal_melanosome_morpholog1.32909326
49MP0005085_abnormal_gallbladder_physiolo1.30695551
50MP0008875_abnormal_xenobiotic_pharmacok1.30434493
51MP0003866_abnormal_defecation1.28558227
52MP0010155_abnormal_intestine_physiology1.27750099
53MP0002736_abnormal_nociception_after1.27484977
54MP0004885_abnormal_endolymph1.21598095
55MP0003252_abnormal_bile_duct1.21371899
56MP0009764_decreased_sensitivity_to1.21280814
57MP0003186_abnormal_redox_activity1.19835912
58MP0000716_abnormal_immune_system1.19413315
59MP0002398_abnormal_bone_marrow1.18962214
60MP0002452_abnormal_antigen_presenting1.17090591
61MP0008877_abnormal_DNA_methylation1.13434448
62MP0001845_abnormal_inflammatory_respons1.12956000
63MP0002876_abnormal_thyroid_physiology1.12877375
64MP0002638_abnormal_pupillary_reflex1.11932192
65MP0002277_abnormal_respiratory_mucosa1.11128462
66MP0003195_calcinosis1.09214616
67MP0001905_abnormal_dopamine_level1.06646427
68MP0000689_abnormal_spleen_morphology1.02185743
69MP0004142_abnormal_muscle_tone1.02100988
70MP0005174_abnormal_tail_pigmentation0.99640784
71MP0001764_abnormal_homeostasis0.97274377
72MP0002429_abnormal_blood_cell0.97199878
73MP0005636_abnormal_mineral_homeostasis0.97136136
74MP0003436_decreased_susceptibility_to0.96706753
75MP0002405_respiratory_system_inflammati0.96254863
76MP0006036_abnormal_mitochondrial_physio0.95930192
77MP0001853_heart_inflammation0.95835438
78MP0003786_premature_aging0.95698031
79MP0005410_abnormal_fertilization0.93119593
80MP0000703_abnormal_thymus_morphology0.93056134
81MP0002722_abnormal_immune_system0.91073531
82MP0002693_abnormal_pancreas_physiology0.88149189
83MP0008995_early_reproductive_senescence0.86518310
84MP0003693_abnormal_embryo_hatching0.85528187
85MP0001440_abnormal_grooming_behavior0.84882850
86MP0001485_abnormal_pinna_reflex0.82682392
87MP0002272_abnormal_nervous_system0.81969224
88MP0005253_abnormal_eye_physiology0.81528185
89MP0005332_abnormal_amino_acid0.80569288
90MP0008469_abnormal_protein_level0.79920168
91MP0000631_abnormal_neuroendocrine_gland0.78143551
92MP0006082_CNS_inflammation0.75228004
93MP0001663_abnormal_digestive_system0.74523113
94MP0001661_extended_life_span0.74356035
95MP0002132_abnormal_respiratory_system0.73656820
96MP0009643_abnormal_urine_homeostasis0.73329521
97MP0003567_abnormal_fetal_cardiomyocyte0.72109282
98MP0002938_white_spotting0.72073738
99MP0002933_joint_inflammation0.70991648
100MP0001765_abnormal_ion_homeostasis0.70736836

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)4.59582481
2Acute necrotizing encephalopathy (HP:0006965)4.36261145
3Mitochondrial inheritance (HP:0001427)4.32152844
4Aplastic anemia (HP:0001915)4.21199555
5Increased CSF lactate (HP:0002490)3.85644328
6Abnormal mitochondria in muscle tissue (HP:0008316)3.82688452
7Hepatocellular necrosis (HP:0001404)3.73180436
8Elevated erythrocyte sedimentation rate (HP:0003565)3.66082111
9Increased hepatocellular lipid droplets (HP:0006565)3.61842591
103-Methylglutaconic aciduria (HP:0003535)3.61413419
11Abnormal rod and cone electroretinograms (HP:0008323)3.59892103
12Acute encephalopathy (HP:0006846)3.59723955
13Progressive macrocephaly (HP:0004481)3.50704813
14Hepatic necrosis (HP:0002605)3.35659812
15Congenital stationary night blindness (HP:0007642)3.34745894
16IgG deficiency (HP:0004315)3.30461731
17Lipid accumulation in hepatocytes (HP:0006561)3.27081282
18Increased IgM level (HP:0003496)3.18699485
19Pancreatic cysts (HP:0001737)3.16606997
20Abnormality of alanine metabolism (HP:0010916)3.08242340
21Hyperalaninemia (HP:0003348)3.08242340
22Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.08242340
23Cerebral edema (HP:0002181)3.05159071
24Renal Fanconi syndrome (HP:0001994)3.00554662
25Increased serum lactate (HP:0002151)2.95858006
26Abnormality of midbrain morphology (HP:0002418)2.92041293
27Molar tooth sign on MRI (HP:0002419)2.92041293
28Attenuation of retinal blood vessels (HP:0007843)2.88192185
29Pendular nystagmus (HP:0012043)2.83919964
30Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.82993334
31Optic disc pallor (HP:0000543)2.82962943
32Stomatitis (HP:0010280)2.80630234
33True hermaphroditism (HP:0010459)2.80462262
34Increased intramyocellular lipid droplets (HP:0012240)2.78762766
35Decreased central vision (HP:0007663)2.75511836
36Exertional dyspnea (HP:0002875)2.62035044
37Lactic acidosis (HP:0003128)2.59391106
38Constricted visual fields (HP:0001133)2.58003427
39Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.56910176
40Decreased electroretinogram (ERG) amplitude (HP:0000654)2.56623123
41Pancreatic fibrosis (HP:0100732)2.51514770
42Severe combined immunodeficiency (HP:0004430)2.49611575
43Abnormality of cells of the erythroid lineage (HP:0012130)2.44327275
44Abnormality of T cell number (HP:0011839)2.39139263
45Abnormal number of erythroid precursors (HP:0012131)2.38874313
46Macrocytic anemia (HP:0001972)2.38036762
47Abnormality of B cell number (HP:0010975)2.37575885
48Abolished electroretinogram (ERG) (HP:0000550)2.36838558
49Increased muscle lipid content (HP:0009058)2.33040418
50Hypoproteinemia (HP:0003075)2.29368561
51T lymphocytopenia (HP:0005403)2.28628108
52Decreased activity of mitochondrial respiratory chain (HP:0008972)2.28505295
53Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.28505295
54Reticulocytopenia (HP:0001896)2.28172116
55Respiratory failure (HP:0002878)2.26514841
56Abnormality of T cells (HP:0002843)2.21956767
57Congenital, generalized hypertrichosis (HP:0004540)2.16552682
58Abnormality of renal resorption (HP:0011038)2.15679749
59Hyperphosphaturia (HP:0003109)2.14975445
60Pancytopenia (HP:0001876)2.14665797
61Lethargy (HP:0001254)2.12299461
62Autoimmune hemolytic anemia (HP:0001890)2.11486455
63Type II lissencephaly (HP:0007260)2.10437833
64Increased corneal curvature (HP:0100692)2.03759575
65Keratoconus (HP:0000563)2.03759575
66Exercise intolerance (HP:0003546)1.99852658
67Type 2 muscle fiber atrophy (HP:0003554)1.98988200
68Respiratory difficulties (HP:0002880)1.98884943
69Acute hepatic failure (HP:0006554)1.98829906
70Thyroiditis (HP:0100646)1.98274438
71Microretrognathia (HP:0000308)1.97715931
72Type I transferrin isoform profile (HP:0003642)1.96742580
73Glycosuria (HP:0003076)1.94797823
74Abnormality of urine glucose concentration (HP:0011016)1.94797823
75Aplasia/Hypoplasia of the spleen (HP:0010451)1.91836951
76Encephalitis (HP:0002383)1.91112847
77Asplenia (HP:0001746)1.90947362
78Abnormality of eosinophils (HP:0001879)1.90796211
79Abnormality of T cell physiology (HP:0011840)1.89872587
80Oral leukoplakia (HP:0002745)1.88330227
81Leukodystrophy (HP:0002415)1.88293247
82Colon cancer (HP:0003003)1.86631533
83Cystic liver disease (HP:0006706)1.85759273
84Chronic sinusitis (HP:0011109)1.85630266
85Pallor (HP:0000980)1.85522852
86Abnormal delayed hypersensitivity skin test (HP:0002963)1.84701579
87Nephronophthisis (HP:0000090)1.84402889
88B lymphocytopenia (HP:0010976)1.84140132
89Cerebral hypomyelination (HP:0006808)1.79259048
90Muscle fiber atrophy (HP:0100295)1.78709923
91Sclerocornea (HP:0000647)1.77994093
92Delayed CNS myelination (HP:0002188)1.77853976
93Combined immunodeficiency (HP:0005387)1.76920906
94Hypoalbuminemia (HP:0003073)1.75323723
95Abnormal albumin level (HP:0012116)1.75323723
96Ketosis (HP:0001946)1.74079962
97CNS demyelination (HP:0007305)1.73412436
98Abnormality of serum amino acid levels (HP:0003112)1.72682861
99Abnormality of the pons (HP:0007361)1.71434124
100Abnormal urine phosphate concentration (HP:0012599)1.71105473

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.71214013
2ZAK3.54291287
3KDR3.34305981
4BCKDK3.23924796
5VRK22.97896901
6NUAK12.63782723
7ADRBK22.58848054
8TIE12.50841545
9GRK12.37049793
10TLK12.30315992
11WNK42.20224805
12MAP4K12.19065575
13STK162.11674530
14VRK12.01347813
15TEC2.00458450
16NME21.92351741
17ITK1.89946341
18MAP4K21.83674018
19TESK21.79319046
20TAOK31.72982289
21MAP3K121.62321106
22MST41.58155815
23FRK1.42614594
24PINK11.40194492
25PASK1.38870560
26PRKCQ1.32974189
27STK391.28018033
28MAP3K111.27265597
29MAP2K61.17330446
30WNK31.09273836
31DYRK21.08914870
32GRK61.06747561
33FES1.04195919
34SYK1.02771391
35IKBKB1.02614386
36PIK3CG1.00892399
37LCK0.99928958
38TAF10.97770213
39MUSK0.96029897
40KIT0.93139352
41MYLK0.91530288
42CDK190.88425598
43TESK10.87421683
44BMPR20.87240806
45NME10.86051867
46EIF2AK10.84785721
47BTK0.84669134
48DAPK10.84595273
49LIMK10.83307263
50ACVR1B0.82697024
51OXSR10.82153833
52PIK3CA0.79299022
53ADRBK10.78405304
54GRK70.76125974
55TRIM280.73983449
56INSRR0.72843570
57AKT30.71754920
58RPS6KA50.70386162
59CSK0.68472908
60LYN0.68098301
61PLK30.64968763
62IKBKE0.64308088
63MAPKAPK30.62044798
64BMPR1B0.60927292
65EIF2AK30.59476174
66JAK30.58532770
67BUB10.58215224
68DAPK30.56832018
69PLK40.54226485
70PIM10.53498644
71RPS6KA40.52171104
72PHKG10.50516593
73PHKG20.50516593
74PRKCA0.48589928
75CSNK2A20.47334552
76CSNK2A10.47134361
77PRKACA0.47040212
78TSSK60.46729744
79PRKCE0.46535276
80CAMKK20.45657243
81DAPK20.45551063
82PIM20.44763050
83TYRO30.44706516
84OBSCN0.44328189
85ABL20.42829589
86SCYL20.42297561
87PRKCG0.40775786
88ATR0.40633700
89CSNK1G30.40278717
90IGF1R0.37738036
91CSNK1A10.37037281
92CCNB10.36671638
93RPS6KB20.34913481
94RIPK40.34811717
95AURKB0.34135614
96PRKCH0.32365615
97TGFBR10.31971335
98CSF1R0.31927470
99MAP3K50.31898873
100STK38L0.31614085

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.07837252
2Proteasome_Homo sapiens_hsa030504.04262720
3Oxidative phosphorylation_Homo sapiens_hsa001903.77013800
4Primary immunodeficiency_Homo sapiens_hsa053403.44306494
5Parkinsons disease_Homo sapiens_hsa050123.04736972
6RNA polymerase_Homo sapiens_hsa030202.99764871
7Graft-versus-host disease_Homo sapiens_hsa053322.46940738
8Allograft rejection_Homo sapiens_hsa053302.32159414
9Autoimmune thyroid disease_Homo sapiens_hsa053202.27894385
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.06114514
11Huntingtons disease_Homo sapiens_hsa050162.04210122
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.03710926
13Alzheimers disease_Homo sapiens_hsa050101.96732292
14Type I diabetes mellitus_Homo sapiens_hsa049401.92905980
15Asthma_Homo sapiens_hsa053101.91704457
16Protein export_Homo sapiens_hsa030601.87895445
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.83614607
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.77355230
19Antigen processing and presentation_Homo sapiens_hsa046121.67129488
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.59347052
21Pyrimidine metabolism_Homo sapiens_hsa002401.49325838
22Sulfur metabolism_Homo sapiens_hsa009201.49271922
23Cardiac muscle contraction_Homo sapiens_hsa042601.49136062
24Linoleic acid metabolism_Homo sapiens_hsa005911.47775749
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47128920
26One carbon pool by folate_Homo sapiens_hsa006701.45941811
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.40938876
28RNA degradation_Homo sapiens_hsa030181.39831641
29Sulfur relay system_Homo sapiens_hsa041221.31703496
30Nitrogen metabolism_Homo sapiens_hsa009101.29667424
31Hematopoietic cell lineage_Homo sapiens_hsa046401.29603662
32Phototransduction_Homo sapiens_hsa047441.29549186
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22246933
34Rheumatoid arthritis_Homo sapiens_hsa053231.21065754
35Homologous recombination_Homo sapiens_hsa034401.15726674
36Purine metabolism_Homo sapiens_hsa002301.13851234
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09008098
38Peroxisome_Homo sapiens_hsa041461.06913339
39Caffeine metabolism_Homo sapiens_hsa002321.03557940
40T cell receptor signaling pathway_Homo sapiens_hsa046600.98066089
41Cysteine and methionine metabolism_Homo sapiens_hsa002700.94689438
42Maturity onset diabetes of the young_Homo sapiens_hsa049500.94644669
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93147605
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89169502
45Propanoate metabolism_Homo sapiens_hsa006400.86297282
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83168908
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82613844
48Tryptophan metabolism_Homo sapiens_hsa003800.82135850
49Butanoate metabolism_Homo sapiens_hsa006500.82047460
50RNA transport_Homo sapiens_hsa030130.79919994
51Basal transcription factors_Homo sapiens_hsa030220.79588892
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78699770
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.70054271
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69722778
55Chemical carcinogenesis_Homo sapiens_hsa052040.69066058
56Metabolic pathways_Homo sapiens_hsa011000.68995592
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68801580
58Fat digestion and absorption_Homo sapiens_hsa049750.68779243
59Base excision repair_Homo sapiens_hsa034100.64488278
60Arachidonic acid metabolism_Homo sapiens_hsa005900.62750680
61Retinol metabolism_Homo sapiens_hsa008300.61968261
62Collecting duct acid secretion_Homo sapiens_hsa049660.61343332
63DNA replication_Homo sapiens_hsa030300.58928843
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58462265
65Spliceosome_Homo sapiens_hsa030400.58374593
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56109321
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.55767395
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55439176
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.54944044
70Viral myocarditis_Homo sapiens_hsa054160.53404479
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.52817492
72Systemic lupus erythematosus_Homo sapiens_hsa053220.52764984
73Regulation of autophagy_Homo sapiens_hsa041400.52697844
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52666710
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51848193
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51839942
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51728984
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49050136
79Olfactory transduction_Homo sapiens_hsa047400.47008271
80Folate biosynthesis_Homo sapiens_hsa007900.46834976
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45350229
82Fanconi anemia pathway_Homo sapiens_hsa034600.45103045
83Ether lipid metabolism_Homo sapiens_hsa005650.44600588
84Nucleotide excision repair_Homo sapiens_hsa034200.42928122
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38391661
86Measles_Homo sapiens_hsa051620.38025118
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37917542
88Vitamin digestion and absorption_Homo sapiens_hsa049770.36577355
89Glutathione metabolism_Homo sapiens_hsa004800.34298106
90Mismatch repair_Homo sapiens_hsa034300.34285290
91Fatty acid degradation_Homo sapiens_hsa000710.33795483
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33219446
93Nicotine addiction_Homo sapiens_hsa050330.32671118
94Mineral absorption_Homo sapiens_hsa049780.31439666
95Epstein-Barr virus infection_Homo sapiens_hsa051690.30632229
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27600893
97Taste transduction_Homo sapiens_hsa047420.25951499
98Fatty acid biosynthesis_Homo sapiens_hsa000610.23783539
99Arginine biosynthesis_Homo sapiens_hsa002200.23607101
100Fatty acid elongation_Homo sapiens_hsa000620.21737344

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