RPL4P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to gravity (GO:0009629)5.48707568
2ribosomal small subunit assembly (GO:0000028)5.24819012
3establishment of protein localization to mitochondrial membrane (GO:0090151)5.24657718
4ATP synthesis coupled proton transport (GO:0015986)5.19523907
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.19523907
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.08401371
7viral transcription (GO:0019083)4.96495538
8maturation of 5.8S rRNA (GO:0000460)4.83385426
9DNA deamination (GO:0045006)4.79707051
10translational termination (GO:0006415)4.73374502
11protein complex biogenesis (GO:0070271)4.53039596
12translational elongation (GO:0006414)4.39704327
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.28164459
14cotranslational protein targeting to membrane (GO:0006613)4.20183646
15ribosomal small subunit biogenesis (GO:0042274)4.19043180
16protein targeting to ER (GO:0045047)4.17523169
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.15249022
18mitochondrial respiratory chain complex assembly (GO:0033108)4.14864846
19RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.10021352
20tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.10021352
21behavioral response to nicotine (GO:0035095)4.07330884
22establishment of protein localization to endoplasmic reticulum (GO:0072599)3.99636046
23chaperone-mediated protein transport (GO:0072321)3.98706402
24protein localization to endoplasmic reticulum (GO:0070972)3.93213427
25cytochrome complex assembly (GO:0017004)3.88278532
26nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.79019049
27mitochondrial respiratory chain complex I assembly (GO:0032981)3.77618814
28NADH dehydrogenase complex assembly (GO:0010257)3.77618814
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.77618814
30protein-cofactor linkage (GO:0018065)3.75683712
31respiratory electron transport chain (GO:0022904)3.75144989
32electron transport chain (GO:0022900)3.70669678
33translational initiation (GO:0006413)3.68485651
34exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.68172329
35positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)3.67211074
36ribosomal large subunit biogenesis (GO:0042273)3.65437606
37protein neddylation (GO:0045116)3.59523165
38translation (GO:0006412)3.56535444
39regulation of skeletal muscle contraction (GO:0014819)3.55731743
40viral life cycle (GO:0019058)3.54328441
41nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.48872616
42pseudouridine synthesis (GO:0001522)3.45408537
43cellular protein complex disassembly (GO:0043624)3.45042315
44maturation of SSU-rRNA (GO:0030490)3.43110732
45water-soluble vitamin biosynthetic process (GO:0042364)3.38972329
46GTP biosynthetic process (GO:0006183)3.38692641
47termination of RNA polymerase III transcription (GO:0006386)3.30434732
48transcription elongation from RNA polymerase III promoter (GO:0006385)3.30434732
49purine nucleoside triphosphate biosynthetic process (GO:0009145)3.28568337
50negative regulation of muscle hypertrophy (GO:0014741)3.27887540
51skeletal muscle tissue regeneration (GO:0043403)3.26789933
52purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.24431337
53protein K6-linked ubiquitination (GO:0085020)3.24375491
54respiratory chain complex IV assembly (GO:0008535)3.24167310
55ATP biosynthetic process (GO:0006754)3.19927767
56cullin deneddylation (GO:0010388)3.18175906
57cellular component biogenesis (GO:0044085)3.18163335
58skeletal muscle adaptation (GO:0043501)3.16086118
59negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.13792299
60striated muscle atrophy (GO:0014891)3.13304359
61response to muscle activity (GO:0014850)3.05496670
62tryptophan catabolic process (GO:0006569)3.04943299
63indole-containing compound catabolic process (GO:0042436)3.04943299
64indolalkylamine catabolic process (GO:0046218)3.04943299
65regulation of mitochondrial translation (GO:0070129)3.04730597
66actin-myosin filament sliding (GO:0033275)3.03515002
67muscle filament sliding (GO:0030049)3.03515002
68regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.99493504
69rRNA processing (GO:0006364)2.99315157
70piRNA metabolic process (GO:0034587)2.97728112
71muscle atrophy (GO:0014889)2.95613313
72ubiquinone biosynthetic process (GO:0006744)2.93396045
73rRNA modification (GO:0000154)2.93289702
74rRNA metabolic process (GO:0016072)2.92965473
75protein deneddylation (GO:0000338)2.91926729
76kynurenine metabolic process (GO:0070189)2.91689288
77protein polyglutamylation (GO:0018095)2.91630786
78sequestering of actin monomers (GO:0042989)2.91300371
79pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.87058088
80ribonucleoside triphosphate biosynthetic process (GO:0009201)2.84891057
81UTP biosynthetic process (GO:0006228)2.83287231
82protein complex disassembly (GO:0043241)2.82972595
83platelet dense granule organization (GO:0060155)2.81325905
84nuclear-transcribed mRNA catabolic process (GO:0000956)2.80506949
85ribonucleoprotein complex biogenesis (GO:0022613)2.79904784
86hydrogen ion transmembrane transport (GO:1902600)2.75408577
87positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.74574250
88preassembly of GPI anchor in ER membrane (GO:0016254)2.71420991
89macromolecular complex disassembly (GO:0032984)2.71020530
90secretory granule organization (GO:0033363)2.70386185
91tryptophan metabolic process (GO:0006568)2.69844647
92protein targeting to membrane (GO:0006612)2.69139093
93cytidine metabolic process (GO:0046087)2.66012599
94cytidine catabolic process (GO:0006216)2.66012599
95cytidine deamination (GO:0009972)2.66012599
96ubiquinone metabolic process (GO:0006743)2.65483962
97UTP metabolic process (GO:0046051)2.63938979
98mRNA catabolic process (GO:0006402)2.63028597
99proton transport (GO:0015992)2.62856685
100RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.61397388

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human4.95401688
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.25431300
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.64239314
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.52897888
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.42011637
6EZH2_22144423_ChIP-Seq_EOC_Human3.34834652
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.08847181
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.77092235
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.71752165
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.48505522
11ZNF274_21170338_ChIP-Seq_K562_Hela2.45932200
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.42255893
13TAF15_26573619_Chip-Seq_HEK293_Human2.35674766
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.35225955
15FUS_26573619_Chip-Seq_HEK293_Human2.13478588
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07139601
17VDR_23849224_ChIP-Seq_CD4+_Human2.05005979
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04613466
19PCGF2_27294783_Chip-Seq_ESCs_Mouse2.00854843
20BP1_19119308_ChIP-ChIP_Hs578T_Human1.95277209
21MYC_18555785_ChIP-Seq_MESCs_Mouse1.82726567
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82553128
23SRF_21415370_ChIP-Seq_HL-1_Mouse1.78959031
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.74194312
25EWS_26573619_Chip-Seq_HEK293_Human1.74066461
26FOXP3_21729870_ChIP-Seq_TREG_Human1.73798505
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71962631
28CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.71660366
29ELK1_19687146_ChIP-ChIP_HELA_Human1.71410349
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67720436
31MYC_18940864_ChIP-ChIP_HL60_Human1.66401334
32IGF1R_20145208_ChIP-Seq_DFB_Human1.63956231
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.63718470
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59662051
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.56557964
36POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.52276100
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51665652
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51648259
39AR_21572438_ChIP-Seq_LNCaP_Human1.50836760
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45929330
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40727061
42GBX2_23144817_ChIP-Seq_PC3_Human1.38038205
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36750472
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.36292405
45TTF2_22483619_ChIP-Seq_HELA_Human1.34061789
46TP53_22573176_ChIP-Seq_HFKS_Human1.32879806
47ER_23166858_ChIP-Seq_MCF-7_Human1.31261247
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29986239
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25613484
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25512551
51IRF1_19129219_ChIP-ChIP_H3396_Human1.25494779
52P300_19829295_ChIP-Seq_ESCs_Human1.23833938
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22782651
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.21659034
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18065496
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.17373583
57RNF2_27304074_Chip-Seq_NSC_Mouse1.16934951
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.13980476
59AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13316144
60NCOR_22424771_ChIP-Seq_293T_Human1.10491853
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10432754
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07800262
63CBP_20019798_ChIP-Seq_JUKART_Human1.07800262
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.06174459
65IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.05820925
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05192876
67EZH2_27304074_Chip-Seq_ESCs_Mouse1.04961760
68NANOG_19829295_ChIP-Seq_ESCs_Human1.03384081
69SOX2_19829295_ChIP-Seq_ESCs_Human1.03384081
70CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01914371
71AR_20517297_ChIP-Seq_VCAP_Human1.00138290
72FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98835723
73FOXA1_25329375_ChIP-Seq_VCAP_Human0.98835723
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98546936
75FOXH1_21741376_ChIP-Seq_EPCs_Human0.96860305
76POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96764679
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94694660
78NANOG_20526341_ChIP-Seq_ESCs_Human0.94503662
79LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93353024
80PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.93096796
81GATA3_21878914_ChIP-Seq_MCF-7_Human0.92574634
82JARID2_20064375_ChIP-Seq_MESCs_Mouse0.89638885
83TP63_19390658_ChIP-ChIP_HaCaT_Human0.88613760
84HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.88492805
85FOXA1_21572438_ChIP-Seq_LNCaP_Human0.88476715
86NOTCH1_21737748_ChIP-Seq_TLL_Human0.86341609
87XRN2_22483619_ChIP-Seq_HELA_Human0.86228662
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86158510
89DCP1A_22483619_ChIP-Seq_HELA_Human0.85678948
90PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85284058
91EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.85118913
92ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84601126
93PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.84332858
94TAF2_19829295_ChIP-Seq_ESCs_Human0.84115759
95EZH2_27294783_Chip-Seq_NPCs_Mouse0.84002009
96PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.83692564
97MYC_19829295_ChIP-Seq_ESCs_Human0.83420339
98ERA_21632823_ChIP-Seq_H3396_Human0.83081281
99E2F4_17652178_ChIP-ChIP_JURKAT_Human0.82820120
100FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.81479122

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio4.17753265
2MP0009379_abnormal_foot_pigmentation3.53833980
3MP0006292_abnormal_olfactory_placode3.18496544
4MP0003646_muscle_fatigue2.67698245
5MP0000372_irregular_coat_pigmentation2.64539443
6MP0002102_abnormal_ear_morphology2.28071888
7MP0008877_abnormal_DNA_methylation2.25661288
8MP0008875_abnormal_xenobiotic_pharmacok2.19892200
9MP0005646_abnormal_pituitary_gland2.12782804
10MP0004147_increased_porphyrin_level2.12467185
11MP0002736_abnormal_nociception_after2.11299136
12MP0006072_abnormal_retinal_apoptosis2.09376543
13MP0001968_abnormal_touch/_nociception2.03116961
14MP0004142_abnormal_muscle_tone1.99946114
15MP0002138_abnormal_hepatobiliary_system1.95617609
16MP0008872_abnormal_physiological_respon1.81953134
17MP0002638_abnormal_pupillary_reflex1.80703787
18MP0004885_abnormal_endolymph1.71989705
19MP0005551_abnormal_eye_electrophysiolog1.65929659
20MP0005671_abnormal_response_to1.56968744
21MP0000631_abnormal_neuroendocrine_gland1.54261428
22MP0005084_abnormal_gallbladder_morpholo1.54190810
23MP0006276_abnormal_autonomic_nervous1.53969023
24MP0002277_abnormal_respiratory_mucosa1.49006045
25MP0003880_abnormal_central_pattern1.48141912
26MP0008789_abnormal_olfactory_epithelium1.47200326
27MP0001905_abnormal_dopamine_level1.44458562
28MP0008058_abnormal_DNA_repair1.43409449
29MP0003786_premature_aging1.38491010
30MP0002837_dystrophic_cardiac_calcinosis1.34593047
31MP0001835_abnormal_antigen_presentation1.34000172
32MP0009745_abnormal_behavioral_response1.33435456
33MP0002095_abnormal_skin_pigmentation1.32815298
34MP0005389_reproductive_system_phenotype1.30127117
35MP0000049_abnormal_middle_ear1.29246494
36MP0002272_abnormal_nervous_system1.29007748
37MP0002160_abnormal_reproductive_system1.28408832
38MP0009250_abnormal_appendicular_skeleto1.26858613
39MP0008995_early_reproductive_senescence1.25192554
40MP0003959_abnormal_lean_body1.22092175
41MP0002876_abnormal_thyroid_physiology1.21551519
42MP0005083_abnormal_biliary_tract1.17703929
43MP0002938_white_spotting1.14725301
44MP0000747_muscle_weakness1.11624773
45MP0002234_abnormal_pharynx_morphology1.10385740
46MP0002163_abnormal_gland_morphology1.07556183
47MP0005645_abnormal_hypothalamus_physiol1.07013357
48MP0005253_abnormal_eye_physiology1.06361827
49MP0003937_abnormal_limbs/digits/tail_de1.05144971
50MP0002089_abnormal_postnatal_growth/wei1.04636686
51MP0003806_abnormal_nucleotide_metabolis1.03055777
52MP0002733_abnormal_thermal_nociception0.99937530
53MP0004133_heterotaxia0.99253897
54MP0002210_abnormal_sex_determination0.98936041
55MP0005423_abnormal_somatic_nervous0.98149513
56MP0001919_abnormal_reproductive_system0.97797510
57MP0001502_abnormal_circadian_rhythm0.97784996
58MP0003195_calcinosis0.97367875
59MP0009046_muscle_twitch0.96490514
60MP0001970_abnormal_pain_threshold0.96298778
61MP0006036_abnormal_mitochondrial_physio0.95121826
62MP0001293_anophthalmia0.94632821
63MP0002735_abnormal_chemical_nociception0.93538903
64MP0002184_abnormal_innervation0.93373529
65MP0004036_abnormal_muscle_relaxation0.91763580
66MP0001661_extended_life_span0.91170629
67MP0005195_abnormal_posterior_eye0.90911596
68MP0000685_abnormal_immune_system0.90857845
69MP0003787_abnormal_imprinting0.90227162
70MP0001529_abnormal_vocalization0.88685268
71MP0001486_abnormal_startle_reflex0.86945965
72MP0003011_delayed_dark_adaptation0.85970882
73MP0000778_abnormal_nervous_system0.85373129
74MP0003136_yellow_coat_color0.84327780
75MP0004043_abnormal_pH_regulation0.83912713
76MP0000749_muscle_degeneration0.83501168
77MP0005410_abnormal_fertilization0.83235399
78MP0000653_abnormal_sex_gland0.82486912
79MP0001119_abnormal_female_reproductive0.82379767
80MP0002752_abnormal_somatic_nervous0.80687725
81MP0002557_abnormal_social/conspecific_i0.80532630
82MP0003938_abnormal_ear_development0.80355322
83MP0002106_abnormal_muscle_physiology0.79932139
84MP0003119_abnormal_digestive_system0.79813524
85MP0003936_abnormal_reproductive_system0.78874736
86MP0003186_abnormal_redox_activity0.77180787
87MP0000026_abnormal_inner_ear0.76593876
88MP0005620_abnormal_muscle_contractility0.76143903
89MP0002108_abnormal_muscle_morphology0.75852559
90MP0003638_abnormal_response/metabolism_0.75801086
91MP0003718_maternal_effect0.75293048
92MP0000427_abnormal_hair_cycle0.73776188
93MP0001145_abnormal_male_reproductive0.72305491
94MP0000613_abnormal_salivary_gland0.71445473
95MP0000230_abnormal_systemic_arterial0.71209923
96MP0006035_abnormal_mitochondrial_morpho0.70010185
97MP0002067_abnormal_sensory_capabilities0.69798347
98MP0001986_abnormal_taste_sensitivity0.68663976
99MP0002148_abnormal_hypersensitivity_rea0.66541727
100MP0002269_muscular_atrophy0.65638640

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.30432010
2Mitochondrial inheritance (HP:0001427)3.98053691
3Absent rod-and cone-mediated responses on ERG (HP:0007688)3.96761499
4Abnormal mitochondria in muscle tissue (HP:0008316)3.66943562
5Acute encephalopathy (HP:0006846)3.58410618
6Increased CSF lactate (HP:0002490)3.57532416
7Progressive macrocephaly (HP:0004481)3.57487895
8Palpebral edema (HP:0100540)3.55579893
93-Methylglutaconic aciduria (HP:0003535)3.51485068
10Pendular nystagmus (HP:0012043)3.43420556
11Abnormality of the phalanges of the 2nd finger (HP:0009541)3.31236350
12True hermaphroditism (HP:0010459)3.28543523
13Hepatocellular necrosis (HP:0001404)3.27925232
14Abnormal rod and cone electroretinograms (HP:0008323)3.20338794
15Pancreatic fibrosis (HP:0100732)3.12840055
16Pancreatic cysts (HP:0001737)3.10286176
17Increased hepatocellular lipid droplets (HP:0006565)3.05368654
18Hepatic necrosis (HP:0002605)3.04694876
19Absent phalangeal crease (HP:0006109)3.01393684
20Abolished electroretinogram (ERG) (HP:0000550)2.99364060
21Molar tooth sign on MRI (HP:0002419)2.85577507
22Abnormality of midbrain morphology (HP:0002418)2.85577507
23Congenital stationary night blindness (HP:0007642)2.79840246
24Nephronophthisis (HP:0000090)2.74620669
25Concave nail (HP:0001598)2.67535668
26Lipid accumulation in hepatocytes (HP:0006561)2.63499572
27Distal arthrogryposis (HP:0005684)2.58787949
28Renal Fanconi syndrome (HP:0001994)2.56303936
29Abnormality of cells of the erythroid lineage (HP:0012130)2.55305146
30Decreased central vision (HP:0007663)2.54942733
31Abnormality of the proximal phalanges of the hand (HP:0009834)2.54748630
32Fibular aplasia (HP:0002990)2.54128349
33Optic disc pallor (HP:0000543)2.53479064
34Cerebral edema (HP:0002181)2.52621258
35Abnormal finger flexion creases (HP:0006143)2.52047589
36Abnormal number of erythroid precursors (HP:0012131)2.49232703
37Increased serum lactate (HP:0002151)2.44800795
38Congenital, generalized hypertrichosis (HP:0004540)2.44297512
39Increased corneal curvature (HP:0100692)2.40620532
40Keratoconus (HP:0000563)2.40620532
41Abnormality of alanine metabolism (HP:0010916)2.37480039
42Hyperalaninemia (HP:0003348)2.37480039
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.37480039
44Abnormality of the renal medulla (HP:0100957)2.35722736
45Abnormality of the middle phalanges of the toes (HP:0010183)2.34674241
46Short tibia (HP:0005736)2.34162061
47Cerebral hypomyelination (HP:0006808)2.31774512
48Macrocytic anemia (HP:0001972)2.29609473
49Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.28554595
50Abnormality of the phalanges of the 5th finger (HP:0004213)2.25593055
51Lactic acidosis (HP:0003128)2.24263769
52Symphalangism affecting the phalanges of the hand (HP:0009773)2.22923746
53Aplasia/Hypoplasia of the tibia (HP:0005772)2.20334530
54Attenuation of retinal blood vessels (HP:0007843)2.20252792
55Agitation (HP:0000713)2.17913160
56Exertional dyspnea (HP:0002875)2.17362164
57Deformed tarsal bones (HP:0008119)2.14035931
58Abnormality of the renal cortex (HP:0011035)2.11674153
59Hypoplasia of the uterus (HP:0000013)2.11054846
60Type 2 muscle fiber atrophy (HP:0003554)2.08555009
61Hypoplasia of the ulna (HP:0003022)2.07845887
62Nemaline bodies (HP:0003798)2.04781707
63Adactyly (HP:0009776)2.04441834
64Type II lissencephaly (HP:0007260)2.04395562
65Colon cancer (HP:0003003)2.03703945
66Aplasia/hypoplasia of the uterus (HP:0008684)2.01239825
67Aplastic anemia (HP:0001915)2.00517266
68Reticulocytopenia (HP:0001896)1.99787465
69Respiratory failure (HP:0002878)1.99130898
70Male pseudohermaphroditism (HP:0000037)1.97742582
71Decreased electroretinogram (ERG) amplitude (HP:0000654)1.96757642
72Aplasia/Hypoplasia of the spleen (HP:0010451)1.95130243
73Anencephaly (HP:0002323)1.95011905
74Asplenia (HP:0001746)1.94430626
75Sclerocornea (HP:0000647)1.93496684
76Renal cortical cysts (HP:0000803)1.90644102
77Forearm undergrowth (HP:0009821)1.87838778
78Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.87717035
79Aplasia/Hypoplasia of the tongue (HP:0010295)1.87473447
80IgG deficiency (HP:0004315)1.85742332
81Hypoplasia of the radius (HP:0002984)1.85333861
82Exercise intolerance (HP:0003546)1.84557424
83Abnormality of renal resorption (HP:0011038)1.83579334
84Dynein arm defect of respiratory motile cilia (HP:0012255)1.82249892
85Absent/shortened dynein arms (HP:0200106)1.82249892
86Aplasia/Hypoplasia of the ulna (HP:0006495)1.81102636
87Mesomelia (HP:0003027)1.81015348
88Periorbital edema (HP:0100539)1.79665986
89Increased intramyocellular lipid droplets (HP:0012240)1.78520252
90Muscle fiber atrophy (HP:0100295)1.78141019
91Elevated erythrocyte sedimentation rate (HP:0003565)1.77180019
92Constricted visual fields (HP:0001133)1.76383554
93Severe muscular hypotonia (HP:0006829)1.73741950
94Pallor (HP:0000980)1.72420105
95Abnormality of the 2nd finger (HP:0004100)1.72022019
96Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.71916834
97CNS demyelination (HP:0007305)1.71607008
98Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.70537179
99Septo-optic dysplasia (HP:0100842)1.68230628
100Leukodystrophy (HP:0002415)1.67985121

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.30649066
2ZAK3.12768541
3WNK42.93839819
4VRK22.88897931
5NME22.77792703
6NUAK12.54916266
7PHKG12.48010668
8PHKG22.48010668
9TAOK32.45188759
10TIE12.32795841
11TLK12.18091569
12TXK2.15424332
13EIF2AK32.13749026
14PINK12.02602817
15FRK1.94945039
16ADRBK21.91140444
17BMPR21.78278419
18BCKDK1.74568818
19VRK11.73527490
20CDK191.69519377
21OBSCN1.65863485
22WNK31.65198283
23TAF11.59778558
24GRK11.56352198
25STK161.49019860
26DYRK21.42902190
27RIPK11.34028006
28MUSK1.30669711
29PIK3CA1.30413690
30STK391.29161313
31OXSR11.17972404
32MAP4K11.12070942
33MAP3K121.10960296
34CASK1.10310002
35MAP3K41.08746730
36PRKCI1.07343137
37NEK11.00242918
38PASK0.99851690
39MAP2K70.97981224
40PRKCG0.96149019
41BMPR1B0.95977859
42BUB10.94253781
43TEC0.94042289
44WNK10.91904347
45SRPK10.88245524
46KDR0.86107913
47PLK30.84946938
48DAPK30.83971593
49MKNK10.82578161
50STK38L0.73890766
51ITK0.73765121
52DAPK10.73069055
53CSNK1G30.72403116
54MST40.72379385
55INSRR0.72039554
56MAPK130.71969000
57DYRK30.70685013
58NME10.69976911
59CSNK1G10.69080058
60CAMKK20.68717904
61PRKCE0.68577704
62EIF2AK20.67119972
63CSNK1G20.66857624
64GRK70.66811872
65LIMK10.66760041
66TNIK0.63529260
67RPS6KA50.63283688
68MAP2K60.62241936
69ADRBK10.59878571
70FLT30.59864605
71CSNK1A1L0.58780959
72TESK20.57205995
73CDK80.57199833
74KIT0.57151784
75PLK40.56120108
76CHEK20.54946032
77ATR0.54878449
78PRKCQ0.54650792
79IKBKB0.54411111
80MAPKAPK50.51343518
81ERBB30.51330330
82JAK30.48843845
83CSNK2A10.48558303
84PIK3CG0.47471592
85DAPK20.46408847
86PRKACA0.46108552
87PDK20.45262830
88PLK20.44782926
89AURKA0.44750207
90MKNK20.43561345
91SYK0.43112955
92CSNK1A10.41834858
93TSSK60.40074830
94MAPKAPK30.40032291
95CSNK2A20.39832815
96CCNB10.39280619
97PRKG10.37695527
98CAMK10.36014071
99PRKCA0.35705831
100MAPK150.33686043

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.90470013
2Oxidative phosphorylation_Homo sapiens_hsa001903.82509614
3Proteasome_Homo sapiens_hsa030503.63737346
4Parkinsons disease_Homo sapiens_hsa050123.16097735
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.58302507
6RNA polymerase_Homo sapiens_hsa030202.50647015
7Asthma_Homo sapiens_hsa053102.50472442
8Protein export_Homo sapiens_hsa030602.32671322
9Huntingtons disease_Homo sapiens_hsa050162.25129886
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.16866773
11Alzheimers disease_Homo sapiens_hsa050102.12580117
12RNA degradation_Homo sapiens_hsa030182.07482700
13Cardiac muscle contraction_Homo sapiens_hsa042602.00884089
14Caffeine metabolism_Homo sapiens_hsa002321.97288589
15Allograft rejection_Homo sapiens_hsa053301.87649159
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.82379174
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.78805991
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.78125199
19Graft-versus-host disease_Homo sapiens_hsa053321.75423552
20Autoimmune thyroid disease_Homo sapiens_hsa053201.73346951
21Regulation of autophagy_Homo sapiens_hsa041401.61684781
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57958266
23Nitrogen metabolism_Homo sapiens_hsa009101.53524592
24Linoleic acid metabolism_Homo sapiens_hsa005911.40511089
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35141999
26Type I diabetes mellitus_Homo sapiens_hsa049401.31141006
27Phototransduction_Homo sapiens_hsa047441.23936070
28RNA transport_Homo sapiens_hsa030131.21838670
29Sulfur relay system_Homo sapiens_hsa041221.21237169
30Homologous recombination_Homo sapiens_hsa034401.20687828
31Basal transcription factors_Homo sapiens_hsa030221.20493027
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19992902
33Pyrimidine metabolism_Homo sapiens_hsa002401.15822612
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08731302
35Primary immunodeficiency_Homo sapiens_hsa053401.07690374
36Tryptophan metabolism_Homo sapiens_hsa003801.07602843
37Fanconi anemia pathway_Homo sapiens_hsa034601.06442546
38One carbon pool by folate_Homo sapiens_hsa006701.05266530
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.02857286
40Purine metabolism_Homo sapiens_hsa002301.02249167
41Spliceosome_Homo sapiens_hsa030400.99648414
42Mismatch repair_Homo sapiens_hsa034300.98853055
43Olfactory transduction_Homo sapiens_hsa047400.95087267
44Maturity onset diabetes of the young_Homo sapiens_hsa049500.94782930
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94459229
46Antigen processing and presentation_Homo sapiens_hsa046120.94231565
47Base excision repair_Homo sapiens_hsa034100.93058357
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87357382
49Peroxisome_Homo sapiens_hsa041460.86193691
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85404379
51Nucleotide excision repair_Homo sapiens_hsa034200.84221570
52DNA replication_Homo sapiens_hsa030300.82587488
53Rheumatoid arthritis_Homo sapiens_hsa053230.81563479
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80165452
55Nicotine addiction_Homo sapiens_hsa050330.78135393
56Butanoate metabolism_Homo sapiens_hsa006500.71095158
57Chemical carcinogenesis_Homo sapiens_hsa052040.70745527
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66740801
59Propanoate metabolism_Homo sapiens_hsa006400.65975730
60Arachidonic acid metabolism_Homo sapiens_hsa005900.62304279
61Ether lipid metabolism_Homo sapiens_hsa005650.60232863
62Morphine addiction_Homo sapiens_hsa050320.58192438
63Metabolic pathways_Homo sapiens_hsa011000.57845888
64Systemic lupus erythematosus_Homo sapiens_hsa053220.57337983
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.56966482
66Tyrosine metabolism_Homo sapiens_hsa003500.55627822
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55452648
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54354362
69Salivary secretion_Homo sapiens_hsa049700.53330288
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52324653
71Tight junction_Homo sapiens_hsa045300.52227461
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.51604048
73Collecting duct acid secretion_Homo sapiens_hsa049660.51443527
74Pyruvate metabolism_Homo sapiens_hsa006200.49325576
75Glutathione metabolism_Homo sapiens_hsa004800.48558303
76Fat digestion and absorption_Homo sapiens_hsa049750.44358132
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40198067
78Hedgehog signaling pathway_Homo sapiens_hsa043400.38807805
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38803714
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38344333
81Serotonergic synapse_Homo sapiens_hsa047260.37694996
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36384444
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36375534
84Insulin secretion_Homo sapiens_hsa049110.35365289
85Selenocompound metabolism_Homo sapiens_hsa004500.35351479
86Retinol metabolism_Homo sapiens_hsa008300.35086826
87Hematopoietic cell lineage_Homo sapiens_hsa046400.34776345
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.34687362
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31176050
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27380962
91T cell receptor signaling pathway_Homo sapiens_hsa046600.27224272
92Taste transduction_Homo sapiens_hsa047420.26431685
93Circadian entrainment_Homo sapiens_hsa047130.26163428
94Oxytocin signaling pathway_Homo sapiens_hsa049210.25432748
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25134277
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24611281
97Calcium signaling pathway_Homo sapiens_hsa040200.24411925
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.23837582
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23153577
100Epstein-Barr virus infection_Homo sapiens_hsa051690.22397235

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