RPL4P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.78213356
2ribosomal small subunit assembly (GO:0000028)6.74235619
3translational termination (GO:0006415)6.59321466
4translational elongation (GO:0006414)6.02624740
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.65556337
6cotranslational protein targeting to membrane (GO:0006613)5.57439886
7protein targeting to ER (GO:0045047)5.52089622
8ATP synthesis coupled proton transport (GO:0015986)5.40758376
9energy coupled proton transport, down electrochemical gradient (GO:0015985)5.40758376
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.28289140
11establishment of protein localization to endoplasmic reticulum (GO:0072599)5.23645980
12ribosomal small subunit biogenesis (GO:0042274)5.20377907
13protein localization to endoplasmic reticulum (GO:0070972)5.18490101
14DNA deamination (GO:0045006)5.15476499
15viral life cycle (GO:0019058)5.01090465
16maturation of SSU-rRNA (GO:0030490)5.00756722
17cellular protein complex disassembly (GO:0043624)4.97884502
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.80205398
19translational initiation (GO:0006413)4.80076788
20RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.64373327
21tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.64373327
22ribosomal large subunit biogenesis (GO:0042273)4.61909203
23protein complex biogenesis (GO:0070271)4.53933009
24translation (GO:0006412)4.32490971
25establishment of protein localization to mitochondrial membrane (GO:0090151)4.29337303
26mitochondrial respiratory chain complex assembly (GO:0033108)4.28876526
27protein neddylation (GO:0045116)4.23378830
28protein complex disassembly (GO:0043241)4.20613334
29mitochondrial respiratory chain complex I assembly (GO:0032981)4.18209637
30NADH dehydrogenase complex assembly (GO:0010257)4.18209637
31mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.18209637
32CTP biosynthetic process (GO:0006241)4.12488465
33CTP metabolic process (GO:0046036)4.12488465
34mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.07760225
35macromolecular complex disassembly (GO:0032984)4.02937197
36chaperone-mediated protein transport (GO:0072321)3.80279926
37pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.68912113
38pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.66560308
39GTP biosynthetic process (GO:0006183)3.65064237
40protein targeting to membrane (GO:0006612)3.64266489
41respiratory electron transport chain (GO:0022904)3.63319416
42nucleotide salvage (GO:0043173)3.62775931
43pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.60870051
44cellular component biogenesis (GO:0044085)3.60360057
45electron transport chain (GO:0022900)3.59182750
46pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.58686324
47ribonucleoprotein complex biogenesis (GO:0022613)3.57203483
48nucleoside salvage (GO:0043174)3.57090215
49nuclear-transcribed mRNA catabolic process (GO:0000956)3.51699847
50behavioral response to nicotine (GO:0035095)3.45046748
51proteasome assembly (GO:0043248)3.39206995
52termination of RNA polymerase III transcription (GO:0006386)3.37719225
53transcription elongation from RNA polymerase III promoter (GO:0006385)3.37719225
54nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.37399196
55sequestering of actin monomers (GO:0042989)3.35294496
56mRNA catabolic process (GO:0006402)3.33241749
57ribonucleoside triphosphate biosynthetic process (GO:0009201)3.30752615
58protein-cofactor linkage (GO:0018065)3.29697575
59purine nucleoside triphosphate biosynthetic process (GO:0009145)3.28008795
60exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.26854329
61purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.26096635
62L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.21329083
63ATP biosynthetic process (GO:0006754)3.13791076
64rRNA processing (GO:0006364)3.08116447
65pyrimidine ribonucleoside biosynthetic process (GO:0046132)3.07107439
66UTP biosynthetic process (GO:0006228)3.05119422
67RNA catabolic process (GO:0006401)3.00304322
68rRNA metabolic process (GO:0016072)2.99766964
69UTP metabolic process (GO:0046051)2.98821936
70response to gravity (GO:0009629)2.98504098
71rRNA modification (GO:0000154)2.98369660
72cullin deneddylation (GO:0010388)2.96414467
73purine nucleotide salvage (GO:0032261)2.94936238
74platelet dense granule organization (GO:0060155)2.93588321
75nucleoside triphosphate biosynthetic process (GO:0009142)2.93099293
76negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.90715809
77pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.88660714
78UMP metabolic process (GO:0046049)2.88660714
79pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.88660714
80UMP biosynthetic process (GO:0006222)2.88660714
81regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.86735278
82pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.85195486
83pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.84900019
84pyrimidine ribonucleoside metabolic process (GO:0046131)2.80663841
85DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.77700518
86respiratory chain complex IV assembly (GO:0008535)2.77453533
87cytidine metabolic process (GO:0046087)2.77100721
88cytidine catabolic process (GO:0006216)2.77100721
89cytidine deamination (GO:0009972)2.77100721
90pseudouridine synthesis (GO:0001522)2.75056357
91hydrogen ion transmembrane transport (GO:1902600)2.75001142
92tRNA processing (GO:0008033)2.74742436
93negative regulation of mast cell activation (GO:0033004)2.73230845
94pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.72528850
95signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.69929241
96signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.69929241
97signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.69929241
98regulation of cellular amino acid metabolic process (GO:0006521)2.69106073
99protein deneddylation (GO:0000338)2.67893215
100intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.65719258

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.55609380
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.42343489
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.91767736
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.73455105
5VDR_22108803_ChIP-Seq_LS180_Human3.48963745
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.12212175
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.02282297
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.01859458
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.84001412
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.76526719
11VDR_23849224_ChIP-Seq_CD4+_Human2.56582321
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.52782402
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.50609576
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.41985287
15ZNF274_21170338_ChIP-Seq_K562_Hela2.37175954
16ELK1_19687146_ChIP-ChIP_HELA_Human2.26573813
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.04008081
18FOXP3_21729870_ChIP-Seq_TREG_Human2.01231974
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.00959547
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.94611477
21TTF2_22483619_ChIP-Seq_HELA_Human1.91397330
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91353073
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.89338457
24MYC_18940864_ChIP-ChIP_HL60_Human1.88273454
25IRF1_19129219_ChIP-ChIP_H3396_Human1.87992175
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.81761054
27EWS_26573619_Chip-Seq_HEK293_Human1.81100839
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.76230460
29POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.70926659
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.68198982
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.67313393
32XRN2_22483619_ChIP-Seq_HELA_Human1.65358327
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.65141245
34FUS_26573619_Chip-Seq_HEK293_Human1.64686780
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.56841185
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53930668
37TAF15_26573619_Chip-Seq_HEK293_Human1.53869715
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47993330
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.47282682
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.46567578
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42890503
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42557409
43TP53_22573176_ChIP-Seq_HFKS_Human1.42416542
44MYC_19030024_ChIP-ChIP_MESCs_Mouse1.37964119
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.37937693
46EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.36937224
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36715398
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34570285
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34449288
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34058957
51EZH2_22144423_ChIP-Seq_EOC_Human1.32548364
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30087178
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27028415
54DCP1A_22483619_ChIP-Seq_HELA_Human1.25141965
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24984559
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.24416334
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24416334
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24363022
59GABP_19822575_ChIP-Seq_HepG2_Human1.22207852
60EED_16625203_ChIP-ChIP_MESCs_Mouse1.21248558
61RNF2_27304074_Chip-Seq_NSC_Mouse1.18830597
62PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.17914110
63IGF1R_20145208_ChIP-Seq_DFB_Human1.16406338
64KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15023958
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14866346
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14488880
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12952979
68ELK1_22589737_ChIP-Seq_MCF10A_Human1.11916917
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11753010
70CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.11647899
71AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11535706
72CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10818646
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10557861
74AR_20517297_ChIP-Seq_VCAP_Human1.09340721
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07790625
76E2F4_17652178_ChIP-ChIP_JURKAT_Human1.06363045
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05405747
78NANOG_19829295_ChIP-Seq_ESCs_Human1.05253435
79SOX2_19829295_ChIP-Seq_ESCs_Human1.05253435
80ERA_21632823_ChIP-Seq_H3396_Human1.03390380
81EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03252968
82NCOR_22424771_ChIP-Seq_293T_Human1.01072152
83P300_19829295_ChIP-Seq_ESCs_Human0.98330196
84BP1_19119308_ChIP-ChIP_Hs578T_Human0.97730712
85PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97502863
86PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.96818582
87TP63_19390658_ChIP-ChIP_HaCaT_Human0.96235673
88PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95963973
89NANOG_20526341_ChIP-Seq_ESCs_Human0.95963715
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95193812
91POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95054961
92IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.94989790
93EZH2_27304074_Chip-Seq_ESCs_Mouse0.94228068
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93636890
95MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.90059888
96CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89541820
97GATA3_21878914_ChIP-Seq_MCF-7_Human0.89380542
98RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.89120210
99FOXH1_21741376_ChIP-Seq_EPCs_Human0.89012792
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.88212086

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.21814071
2MP0006292_abnormal_olfactory_placode3.34187341
3MP0003806_abnormal_nucleotide_metabolis3.10867653
4MP0002163_abnormal_gland_morphology2.91429420
5MP0003011_delayed_dark_adaptation2.66553407
6MP0002102_abnormal_ear_morphology2.35557607
7MP0008875_abnormal_xenobiotic_pharmacok2.26860096
8MP0008872_abnormal_physiological_respon2.14599295
9MP0008058_abnormal_DNA_repair2.00098441
10MP0003646_muscle_fatigue1.98048249
11MP0001529_abnormal_vocalization1.95610389
12MP0002277_abnormal_respiratory_mucosa1.88540430
13MP0002938_white_spotting1.88152029
14MP0006072_abnormal_retinal_apoptosis1.87231429
15MP0004145_abnormal_muscle_electrophysio1.86516076
16MP0000049_abnormal_middle_ear1.77850012
17MP0004885_abnormal_endolymph1.76924794
18MP0002095_abnormal_skin_pigmentation1.76745975
19MP0002638_abnormal_pupillary_reflex1.74678975
20MP0000372_irregular_coat_pigmentation1.74371533
21MP0005645_abnormal_hypothalamus_physiol1.72034036
22MP0002138_abnormal_hepatobiliary_system1.68328659
23MP0005084_abnormal_gallbladder_morpholo1.65025717
24MP0004147_increased_porphyrin_level1.60558981
25MP0004142_abnormal_muscle_tone1.59484274
26MP0008877_abnormal_DNA_methylation1.57924331
27MP0005379_endocrine/exocrine_gland_phen1.55553134
28MP0002736_abnormal_nociception_after1.49109140
29MP0005551_abnormal_eye_electrophysiolog1.45600224
30MP0005646_abnormal_pituitary_gland1.45082495
31MP0006276_abnormal_autonomic_nervous1.41953991
32MP0005671_abnormal_response_to1.38841645
33MP0001873_stomach_inflammation1.37626610
34MP0003718_maternal_effect1.34327881
35MP0003880_abnormal_central_pattern1.30999469
36MP0001905_abnormal_dopamine_level1.29832163
37MP0000631_abnormal_neuroendocrine_gland1.28144071
38MP0003186_abnormal_redox_activity1.27471095
39MP0004133_heterotaxia1.24945913
40MP0008995_early_reproductive_senescence1.21553872
41MP0001968_abnormal_touch/_nociception1.19578317
42MP0004742_abnormal_vestibular_system1.17974329
43MP0003136_yellow_coat_color1.16681345
44MP0008789_abnormal_olfactory_epithelium1.16246113
45MP0003786_premature_aging1.15890551
46MP0005389_reproductive_system_phenotype1.14218152
47MP0002160_abnormal_reproductive_system1.14057212
48MP0005377_hearing/vestibular/ear_phenot1.13079092
49MP0003878_abnormal_ear_physiology1.13079092
50MP0001485_abnormal_pinna_reflex1.12479225
51MP0002735_abnormal_chemical_nociception1.11949621
52MP0005075_abnormal_melanosome_morpholog1.07462856
53MP0001879_abnormal_lymphatic_vessel1.07031289
54MP0002272_abnormal_nervous_system1.06218681
55MP0006036_abnormal_mitochondrial_physio1.05843135
56MP0001293_anophthalmia1.05471352
57MP0003693_abnormal_embryo_hatching1.04980070
58MP0002234_abnormal_pharynx_morphology1.04688817
59MP0005253_abnormal_eye_physiology1.04331673
60MP0009745_abnormal_behavioral_response1.03170262
61MP0001764_abnormal_homeostasis1.03067528
62MP0003315_abnormal_perineum_morphology1.01042180
63MP0002837_dystrophic_cardiac_calcinosis1.00744144
64MP0000566_synostosis0.99174575
65MP0005423_abnormal_somatic_nervous0.96964583
66MP0009333_abnormal_splenocyte_physiolog0.95494482
67MP0003283_abnormal_digestive_organ0.94878049
68MP0001835_abnormal_antigen_presentation0.91874823
69MP0002282_abnormal_trachea_morphology0.91125705
70MP0002210_abnormal_sex_determination0.90570120
71MP0003567_abnormal_fetal_cardiomyocyte0.90415459
72MP0000026_abnormal_inner_ear0.90112092
73MP0002822_catalepsy0.89200005
74MP0001919_abnormal_reproductive_system0.88969621
75MP0009250_abnormal_appendicular_skeleto0.86903213
76MP0001663_abnormal_digestive_system0.85564189
77MP0002653_abnormal_ependyma_morphology0.83334683
78MP0000647_abnormal_sebaceous_gland0.83258718
79MP0002557_abnormal_social/conspecific_i0.79537404
80MP0009697_abnormal_copulation0.78533483
81MP0002752_abnormal_somatic_nervous0.77978493
82MP0005195_abnormal_posterior_eye0.76658397
83MP0003937_abnormal_limbs/digits/tail_de0.76639944
84MP0001970_abnormal_pain_threshold0.75165484
85MP0006035_abnormal_mitochondrial_morpho0.74829526
86MP0002184_abnormal_innervation0.73920109
87MP0005085_abnormal_gallbladder_physiolo0.72399413
88MP0002148_abnormal_hypersensitivity_rea0.71813841
89MP0001486_abnormal_startle_reflex0.71248886
90MP0001440_abnormal_grooming_behavior0.69467553
91MP0000653_abnormal_sex_gland0.67440097
92MP0003195_calcinosis0.67402813
93MP0005332_abnormal_amino_acid0.66994576
94MP0004957_abnormal_blastocyst_morpholog0.65961630
95MP0001986_abnormal_taste_sensitivity0.65637765
96MP0001145_abnormal_male_reproductive0.65357634
97MP0003638_abnormal_response/metabolism_0.64943809
98MP0002876_abnormal_thyroid_physiology0.64358888
99MP0000613_abnormal_salivary_gland0.63855996
100MP0001119_abnormal_female_reproductive0.63352358

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.80951539
2Abnormal number of erythroid precursors (HP:0012131)4.64705243
3Increased hepatocellular lipid droplets (HP:0006565)4.63356814
4Abnormality of cells of the erythroid lineage (HP:0012130)4.58200147
5Mitochondrial inheritance (HP:0001427)4.50852569
6Abnormal mitochondria in muscle tissue (HP:0008316)4.25614313
7Acute encephalopathy (HP:0006846)4.06198176
8Increased CSF lactate (HP:0002490)4.04701403
9Progressive macrocephaly (HP:0004481)4.03181508
10Renal Fanconi syndrome (HP:0001994)4.01933059
11Lipid accumulation in hepatocytes (HP:0006561)3.97468503
12Absent rod-and cone-mediated responses on ERG (HP:0007688)3.90275012
13Optic disc pallor (HP:0000543)3.36716742
14Hepatocellular necrosis (HP:0001404)3.24032842
153-Methylglutaconic aciduria (HP:0003535)3.20867274
16Macrocytic anemia (HP:0001972)3.17831384
17Exertional dyspnea (HP:0002875)3.14106063
18Decreased central vision (HP:0007663)3.13487906
19Abnormality of alanine metabolism (HP:0010916)3.12680872
20Hyperalaninemia (HP:0003348)3.12680872
21Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.12680872
22Pancreatic cysts (HP:0001737)3.11703855
23Pendular nystagmus (HP:0012043)3.07978842
24Cerebral edema (HP:0002181)3.04208446
25Abnormality of midbrain morphology (HP:0002418)3.03438270
26Molar tooth sign on MRI (HP:0002419)3.03438270
27Attenuation of retinal blood vessels (HP:0007843)3.02418786
28Increased intramyocellular lipid droplets (HP:0012240)2.99078778
29Reticulocytopenia (HP:0001896)2.98756784
30True hermaphroditism (HP:0010459)2.97153462
31Increased serum lactate (HP:0002151)2.96444050
32Opisthotonus (HP:0002179)2.96323752
33Hepatic necrosis (HP:0002605)2.95840026
34Abnormal rod and cone electroretinograms (HP:0008323)2.95680324
35Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.94230924
36Congenital stationary night blindness (HP:0007642)2.75915308
37Pancreatic fibrosis (HP:0100732)2.73088502
38Lactic acidosis (HP:0003128)2.72270813
39Abnormality of renal resorption (HP:0011038)2.67954444
40Congenital, generalized hypertrichosis (HP:0004540)2.59625831
41Abolished electroretinogram (ERG) (HP:0000550)2.51788699
42Abnormality of the pons (HP:0007361)2.51665331
43Hypoplasia of the pons (HP:0012110)2.44957055
44Pallor (HP:0000980)2.36526821
45Respiratory difficulties (HP:0002880)2.32897274
46Aplastic anemia (HP:0001915)2.31866042
47Retinal dysplasia (HP:0007973)2.26147691
48Exercise intolerance (HP:0003546)2.24578116
49Increased muscle lipid content (HP:0009058)2.23893928
50Respiratory failure (HP:0002878)2.23019991
51Colon cancer (HP:0003003)2.20512949
52Keratoconus (HP:0000563)2.18688955
53Increased corneal curvature (HP:0100692)2.18688955
54Abnormality of urine glucose concentration (HP:0011016)2.18146432
55Glycosuria (HP:0003076)2.18146432
56Decreased electroretinogram (ERG) amplitude (HP:0000654)2.17226612
57Aplasia/hypoplasia of the uterus (HP:0008684)2.16646012
58Lethargy (HP:0001254)2.13665724
59Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.13044942
60Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.10797183
61Decreased activity of mitochondrial respiratory chain (HP:0008972)2.10797183
62IgG deficiency (HP:0004315)2.07356853
63Hyperglycinemia (HP:0002154)2.07236197
64Hyperphosphaturia (HP:0003109)2.05986258
65Nephronophthisis (HP:0000090)2.04568172
66Cerebral hypomyelination (HP:0006808)2.04357284
67Abnormality of serum amino acid levels (HP:0003112)2.02053261
68Stenosis of the external auditory canal (HP:0000402)2.01255355
69Anencephaly (HP:0002323)1.99678505
70Leukodystrophy (HP:0002415)1.98168543
71Medial flaring of the eyebrow (HP:0010747)1.98133412
72Palpebral edema (HP:0100540)1.97179551
73Type 2 muscle fiber atrophy (HP:0003554)1.94535910
74Abnormality of the renal cortex (HP:0011035)1.91252454
75Type II lissencephaly (HP:0007260)1.88964744
76Male pseudohermaphroditism (HP:0000037)1.86208534
77Abnormality of the renal medulla (HP:0100957)1.86072630
78Sclerocornea (HP:0000647)1.85665761
79CNS demyelination (HP:0007305)1.84086724
80Hypoproteinemia (HP:0003075)1.83598455
81Aplasia/Hypoplasia of the tongue (HP:0010295)1.82222395
82Renal cortical cysts (HP:0000803)1.82167231
83Panhypogammaglobulinemia (HP:0003139)1.81815108
84Asplenia (HP:0001746)1.81641130
85Short tibia (HP:0005736)1.79398162
86X-linked dominant inheritance (HP:0001423)1.78279333
87Aplasia/Hypoplasia of the spleen (HP:0010451)1.78017154
88Hypoplasia of the uterus (HP:0000013)1.76559372
89Delayed CNS myelination (HP:0002188)1.75629447
90Poor suck (HP:0002033)1.70636474
91Abnormality of B cell number (HP:0010975)1.70485532
92Constricted visual fields (HP:0001133)1.67401333
93Blindness (HP:0000618)1.64870568
94Symphalangism affecting the phalanges of the hand (HP:0009773)1.64764686
95Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.64468718
96Abnormality of the phalanges of the 5th finger (HP:0004213)1.64099793
97Aplasia/Hypoplasia of the tibia (HP:0005772)1.62406921
98Methylmalonic aciduria (HP:0012120)1.61736180
99Stomatitis (HP:0010280)1.59858917
100Progressive microcephaly (HP:0000253)1.59785997

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.37321750
2NME23.17826407
3MAP4K22.82899142
4ZAK2.71520154
5NUAK12.70804244
6TLK12.55431152
7LIMK12.53658890
8GRK12.21131069
9ADRBK22.20882054
10BCKDK2.06852466
11MST41.99912926
12WNK31.96832787
13STK161.96205139
14VRK11.95783720
15DYRK21.87730509
16PINK11.84605907
17TIE11.82972352
18CDK191.81746705
19CASK1.70559807
20WNK41.60598078
21TXK1.57967081
22PHKG11.57236756
23PHKG21.57236756
24PASK1.51872979
25TAOK31.50542133
26KDR1.47196554
27TAF11.46684783
28BUB11.45503996
29MAPK151.41548311
30MAP4K11.35967377
31CDK81.34884119
32SRPK11.29417318
33TSSK61.23424223
34WEE11.22375220
35CAMKK21.14475235
36PIK3CA1.12500144
37NME11.10200660
38MAPKAPK51.06995274
39MAP3K121.05898203
40FRK1.04171028
41CSNK1G31.02418205
42EPHB21.02185316
43CSNK1G11.02138530
44TESK11.01198332
45OXSR11.00655324
46PNCK1.00229707
47PLK41.00056841
48MAPK130.99928869
49TEC0.98179710
50RPS6KA50.92440838
51ADRBK10.90475262
52CSNK1G20.88670374
53DYRK30.87927489
54MKNK10.81772597
55AURKA0.79307213
56CSNK1A1L0.77763331
57MAP2K70.75429819
58PLK30.73382668
59KIT0.71071969
60CCNB10.70095038
61OBSCN0.69539431
62PBK0.69374527
63TRIM280.68595367
64ABL20.68210393
65TESK20.65187830
66INSRR0.64765057
67TGFBR10.64742015
68CSNK2A20.64510729
69PRKCG0.63958369
70IKBKB0.62778033
71CSNK2A10.62177402
72STK390.59621866
73CHEK20.57047198
74PRKCQ0.56420930
75LRRK20.56305555
76MAPKAPK30.54627306
77EIF2AK30.54010111
78ITK0.52906621
79BMPR1B0.51536663
80NEK10.51503587
81MUSK0.51185202
82PLK10.51109093
83MAP3K40.49246423
84SYK0.48595471
85IRAK10.48477850
86PIK3CG0.48193804
87ATR0.42304621
88CSNK1A10.41874043
89MYLK0.41339080
90PRKACA0.40820753
91DAPK30.39258481
92CDC70.38766578
93DAPK10.38723730
94RPS6KA40.38694860
95AURKB0.36649675
96PRKCE0.36644959
97EIF2AK20.36411168
98GRK50.34211049
99PRKCA0.33905238
100PRKCI0.31774782

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.77359714
2Oxidative phosphorylation_Homo sapiens_hsa001903.70728309
3Proteasome_Homo sapiens_hsa030503.64229490
4Sulfur relay system_Homo sapiens_hsa041223.49456082
5Parkinsons disease_Homo sapiens_hsa050123.15991830
6RNA polymerase_Homo sapiens_hsa030202.53032720
7Protein export_Homo sapiens_hsa030602.22474181
8Huntingtons disease_Homo sapiens_hsa050162.16588229
9Alzheimers disease_Homo sapiens_hsa050102.09612896
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.98963447
11Asthma_Homo sapiens_hsa053101.84338801
12DNA replication_Homo sapiens_hsa030301.79530664
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.71873744
14Pyrimidine metabolism_Homo sapiens_hsa002401.65040181
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.58995340
16Allograft rejection_Homo sapiens_hsa053301.53347816
17Primary immunodeficiency_Homo sapiens_hsa053401.52167742
18Linoleic acid metabolism_Homo sapiens_hsa005911.50352398
19Homologous recombination_Homo sapiens_hsa034401.50039768
20Cardiac muscle contraction_Homo sapiens_hsa042601.47619749
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41190119
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.39360176
23Autoimmune thyroid disease_Homo sapiens_hsa053201.37678732
24Sulfur metabolism_Homo sapiens_hsa009201.35943166
25RNA degradation_Homo sapiens_hsa030181.35937967
26Mismatch repair_Homo sapiens_hsa034301.30668436
27Base excision repair_Homo sapiens_hsa034101.28357671
28One carbon pool by folate_Homo sapiens_hsa006701.27838906
29Graft-versus-host disease_Homo sapiens_hsa053321.25839153
30Phototransduction_Homo sapiens_hsa047441.25117047
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24484736
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.22349077
33Folate biosynthesis_Homo sapiens_hsa007901.21433707
34Nucleotide excision repair_Homo sapiens_hsa034201.20593466
35Purine metabolism_Homo sapiens_hsa002301.16875778
36Basal transcription factors_Homo sapiens_hsa030221.11916163
37Spliceosome_Homo sapiens_hsa030401.09985955
38Type I diabetes mellitus_Homo sapiens_hsa049401.09901011
39Nitrogen metabolism_Homo sapiens_hsa009101.07225298
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06859951
41RNA transport_Homo sapiens_hsa030131.06771494
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06468216
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.04022871
44Fanconi anemia pathway_Homo sapiens_hsa034600.98764047
45Caffeine metabolism_Homo sapiens_hsa002320.97370768
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95021783
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.94265514
48Antigen processing and presentation_Homo sapiens_hsa046120.94073760
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92010977
50Arachidonic acid metabolism_Homo sapiens_hsa005900.89630233
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.88277153
52Glutathione metabolism_Homo sapiens_hsa004800.86596687
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.86016796
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85881801
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83358348
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81839371
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80819505
58Propanoate metabolism_Homo sapiens_hsa006400.80477687
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77937873
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77220707
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75412239
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73152172
63Butanoate metabolism_Homo sapiens_hsa006500.73041147
64Chemical carcinogenesis_Homo sapiens_hsa052040.72145263
65Rheumatoid arthritis_Homo sapiens_hsa053230.71427064
66Metabolic pathways_Homo sapiens_hsa011000.67560958
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.66726130
68Hematopoietic cell lineage_Homo sapiens_hsa046400.63458434
69Olfactory transduction_Homo sapiens_hsa047400.62077423
70Peroxisome_Homo sapiens_hsa041460.61692543
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60686619
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.60059304
73Fatty acid elongation_Homo sapiens_hsa000620.59362780
74Systemic lupus erythematosus_Homo sapiens_hsa053220.59133843
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58511720
76Fat digestion and absorption_Homo sapiens_hsa049750.58123478
77Pyruvate metabolism_Homo sapiens_hsa006200.55036687
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54506512
79Regulation of autophagy_Homo sapiens_hsa041400.52936686
80Retinol metabolism_Homo sapiens_hsa008300.51395314
81Salivary secretion_Homo sapiens_hsa049700.43820842
82Tryptophan metabolism_Homo sapiens_hsa003800.42607240
83Collecting duct acid secretion_Homo sapiens_hsa049660.42313113
84Taste transduction_Homo sapiens_hsa047420.40668506
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38394957
86Selenocompound metabolism_Homo sapiens_hsa004500.36467409
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35106491
88Ether lipid metabolism_Homo sapiens_hsa005650.34967143
89Nicotine addiction_Homo sapiens_hsa050330.31758045
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30606375
91Arginine and proline metabolism_Homo sapiens_hsa003300.27760707
92Basal cell carcinoma_Homo sapiens_hsa052170.27008384
93Non-homologous end-joining_Homo sapiens_hsa034500.24165182
94Morphine addiction_Homo sapiens_hsa050320.20910830
95Hedgehog signaling pathway_Homo sapiens_hsa043400.19574321
96Steroid biosynthesis_Homo sapiens_hsa001000.18245678
97Serotonergic synapse_Homo sapiens_hsa047260.17713544
98Epstein-Barr virus infection_Homo sapiens_hsa051690.16447367
99Viral myocarditis_Homo sapiens_hsa054160.16136681
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15279151

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »