RPL4P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.19033671
2ribosomal small subunit assembly (GO:0000028)5.90173539
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.82385603
4cytidine catabolic process (GO:0006216)5.37450611
5cytidine deamination (GO:0009972)5.37450611
6cytidine metabolic process (GO:0046087)5.37450611
7maturation of SSU-rRNA (GO:0030490)5.08622394
8energy coupled proton transport, down electrochemical gradient (GO:0015985)4.69699369
9ATP synthesis coupled proton transport (GO:0015986)4.69699369
10pyrimidine ribonucleoside catabolic process (GO:0046133)4.69155392
11viral transcription (GO:0019083)4.67704834
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.61811857
13translational termination (GO:0006415)4.51434654
14translational elongation (GO:0006414)4.16394192
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.11324071
16cotranslational protein targeting to membrane (GO:0006613)4.05007098
17ribosomal large subunit biogenesis (GO:0042273)4.03558431
18protein targeting to ER (GO:0045047)4.01984682
19establishment of protein localization to endoplasmic reticulum (GO:0072599)3.82318374
20protein localization to endoplasmic reticulum (GO:0070972)3.81558766
21establishment of protein localization to mitochondrial membrane (GO:0090151)3.76219849
22ribosomal small subunit biogenesis (GO:0042274)3.73037265
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.68766880
24protein neddylation (GO:0045116)3.66595068
25nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.66165089
26respiratory electron transport chain (GO:0022904)3.62910039
27electron transport chain (GO:0022900)3.60597308
28tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.56352004
29RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.56352004
30regulation of regulatory T cell differentiation (GO:0045589)3.52373578
31proteasome assembly (GO:0043248)3.49536447
32sequestering of actin monomers (GO:0042989)3.49532164
33exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.49050286
34platelet dense granule organization (GO:0060155)3.38339308
35viral life cycle (GO:0019058)3.37080784
36translational initiation (GO:0006413)3.33517598
37cellular protein complex disassembly (GO:0043624)3.32391010
38nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.29727928
39translation (GO:0006412)3.25918810
40water-soluble vitamin biosynthetic process (GO:0042364)3.22922908
41chaperone-mediated protein transport (GO:0072321)3.20218708
42iron-sulfur cluster assembly (GO:0016226)3.18271772
43metallo-sulfur cluster assembly (GO:0031163)3.18271772
44behavioral response to nicotine (GO:0035095)3.11608774
45regulation of cellular amino acid metabolic process (GO:0006521)3.09844607
46protein complex biogenesis (GO:0070271)3.09699917
47negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.08086844
48DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.04266395
49positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.03611794
50Arp2/3 complex-mediated actin nucleation (GO:0034314)3.00890459
51signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.95729632
52signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.95729632
53signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.95729632
54mitochondrial respiratory chain complex I assembly (GO:0032981)2.94232557
55NADH dehydrogenase complex assembly (GO:0010257)2.94232557
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.94232557
57signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.91883071
58intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.91883071
59positive regulation of defense response to virus by host (GO:0002230)2.90526833
60ribonucleoprotein complex biogenesis (GO:0022613)2.90486702
61ubiquinone biosynthetic process (GO:0006744)2.87367694
62cellular component biogenesis (GO:0044085)2.87333907
63base-excision repair, AP site formation (GO:0006285)2.86733100
64hydrogen ion transmembrane transport (GO:1902600)2.84373468
65positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.83594534
66positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.82268900
67negative regulation of T cell apoptotic process (GO:0070233)2.81259162
68actin nucleation (GO:0045010)2.80504601
69mitochondrial respiratory chain complex assembly (GO:0033108)2.79721245
70signal transduction involved in DNA damage checkpoint (GO:0072422)2.78631300
71signal transduction involved in DNA integrity checkpoint (GO:0072401)2.78631300
72RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.77720469
73proton transport (GO:0015992)2.76013560
74negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.75743251
75negative regulation of ligase activity (GO:0051352)2.75743251
76signal transduction involved in cell cycle checkpoint (GO:0072395)2.75386565
77pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.74860155
78ATP biosynthetic process (GO:0006754)2.73894884
79pseudouridine synthesis (GO:0001522)2.73476360
80positive T cell selection (GO:0043368)2.72740954
81hydrogen transport (GO:0006818)2.70367109
82protein complex disassembly (GO:0043241)2.68869697
83respiratory chain complex IV assembly (GO:0008535)2.68026214
84purine nucleoside triphosphate biosynthetic process (GO:0009145)2.67860634
85positive thymic T cell selection (GO:0045059)2.67280626
86rRNA processing (GO:0006364)2.66226248
87termination of RNA polymerase III transcription (GO:0006386)2.66157917
88transcription elongation from RNA polymerase III promoter (GO:0006385)2.66157917
89rRNA metabolic process (GO:0016072)2.65783145
90antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.64860660
91nuclear-transcribed mRNA catabolic process (GO:0000956)2.64743080
92regulation of chronic inflammatory response (GO:0002676)2.64177629
93purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.61881169
94ubiquinone metabolic process (GO:0006743)2.61508420
95regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.60706780
96macromolecular complex disassembly (GO:0032984)2.59401193
97regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.58286802
98protein targeting to membrane (GO:0006612)2.57978313
99positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.55191437
100protein-cofactor linkage (GO:0018065)2.55045765

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.96748222
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.72882350
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.62440684
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.50564990
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.49303322
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.30734352
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.22080402
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.92325574
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.84504261
10VDR_22108803_ChIP-Seq_LS180_Human2.60944532
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.57011886
12VDR_23849224_ChIP-Seq_CD4+_Human2.55466857
13ZNF274_21170338_ChIP-Seq_K562_Hela2.43238538
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.28119597
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.25794389
16EZH2_22144423_ChIP-Seq_EOC_Human2.23954777
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.19243930
18ELK1_19687146_ChIP-ChIP_HELA_Human2.17279642
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08856154
20FOXP3_21729870_ChIP-Seq_TREG_Human2.06972912
21SRF_21415370_ChIP-Seq_HL-1_Mouse1.93084806
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.90768672
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.88581610
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.87166879
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.87049381
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.82077501
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.69760121
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65916255
29IGF1R_20145208_ChIP-Seq_DFB_Human1.65592900
30MYC_18940864_ChIP-ChIP_HL60_Human1.62394473
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.61750460
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57548591
33TP53_22573176_ChIP-Seq_HFKS_Human1.53651365
34EWS_26573619_Chip-Seq_HEK293_Human1.51613707
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.50519436
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.49711633
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48314460
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47802820
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.46803623
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45997158
41MYB_26560356_Chip-Seq_TH2_Human1.44839680
42AR_20517297_ChIP-Seq_VCAP_Human1.38642034
43FOXA1_25329375_ChIP-Seq_VCAP_Human1.35439958
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35439958
45GATA3_26560356_Chip-Seq_TH2_Human1.35422063
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33776662
47NCOR_22424771_ChIP-Seq_293T_Human1.32947344
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26347635
49TTF2_22483619_ChIP-Seq_HELA_Human1.24994465
50PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.22792723
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21100337
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20409738
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20081355
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18912996
55RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.17517186
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16745735
57ER_23166858_ChIP-Seq_MCF-7_Human1.16338716
58FUS_26573619_Chip-Seq_HEK293_Human1.15896698
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15835881
60EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14929552
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13286712
62GABP_19822575_ChIP-Seq_HepG2_Human1.13258602
63NANOG_20526341_ChIP-Seq_ESCs_Human1.12560125
64GATA3_27048872_Chip-Seq_THYMUS_Human1.12534009
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12508995
66IRF1_19129219_ChIP-ChIP_H3396_Human1.11666209
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11606427
68PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11218549
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.10281217
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10061846
71TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.09935568
72FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.09541205
73AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08042131
74CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07922772
75TAF2_19829295_ChIP-Seq_ESCs_Human1.07219219
76TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05629131
77CIITA_25753668_ChIP-Seq_RAJI_Human1.05258925
78CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04990251
79FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04907867
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04110347
81CBP_20019798_ChIP-Seq_JUKART_Human1.04110347
82SOX2_19829295_ChIP-Seq_ESCs_Human1.04070626
83NANOG_19829295_ChIP-Seq_ESCs_Human1.04070626
84FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03280347
85TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02248743
86MYC_19829295_ChIP-Seq_ESCs_Human1.01855796
87MYC_19030024_ChIP-ChIP_MESCs_Mouse0.99186636
88CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99085049
89XRN2_22483619_ChIP-Seq_HELA_Human0.98009745
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97790532
91ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95644267
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95256679
93HOXB7_26014856_ChIP-Seq_BT474_Human0.95157133
94ERG_20517297_ChIP-Seq_VCAP_Human0.91794544
95FOXH1_21741376_ChIP-Seq_EPCs_Human0.91711838
96ELK1_22589737_ChIP-Seq_MCF10A_Human0.91634277
97STAT4_19710469_ChIP-ChIP_TH1__Mouse0.90999952
98ERA_21632823_ChIP-Seq_H3396_Human0.90344147
99PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89995932
100RUNX_20019798_ChIP-Seq_JUKART_Human0.88182176

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.47118836
2MP0009379_abnormal_foot_pigmentation3.77305865
3MP0001835_abnormal_antigen_presentation2.80209235
4MP0004147_increased_porphyrin_level2.74842702
5MP0009785_altered_susceptibility_to2.41775144
6MP0002102_abnormal_ear_morphology2.11023468
7MP0006292_abnormal_olfactory_placode2.01848034
8MP0008872_abnormal_physiological_respon2.00890052
9MP0006072_abnormal_retinal_apoptosis1.98742087
10MP0003763_abnormal_thymus_physiology1.98468546
11MP0009333_abnormal_splenocyte_physiolog1.90269396
12MP0002138_abnormal_hepatobiliary_system1.88471891
13MP0001800_abnormal_humoral_immune1.84980155
14MP0008877_abnormal_DNA_methylation1.84276256
15MP0005075_abnormal_melanosome_morpholog1.83357089
16MP0002163_abnormal_gland_morphology1.80946188
17MP0003806_abnormal_nucleotide_metabolis1.80624044
18MP0005000_abnormal_immune_tolerance1.80033902
19MP0000685_abnormal_immune_system1.77073624
20MP0005084_abnormal_gallbladder_morpholo1.76761393
21MP0005645_abnormal_hypothalamus_physiol1.73038058
22MP0003646_muscle_fatigue1.66887161
23MP0002148_abnormal_hypersensitivity_rea1.66750206
24MP0004145_abnormal_muscle_electrophysio1.64000760
25MP0000372_irregular_coat_pigmentation1.61682768
26MP0003866_abnormal_defecation1.56187649
27MP0002837_dystrophic_cardiac_calcinosis1.56164760
28MP0002723_abnormal_immune_serum1.55058911
29MP0001968_abnormal_touch/_nociception1.54786010
30MP0001873_stomach_inflammation1.53721670
31MP0008875_abnormal_xenobiotic_pharmacok1.53283770
32MP0005377_hearing/vestibular/ear_phenot1.52403881
33MP0003878_abnormal_ear_physiology1.52403881
34MP0001529_abnormal_vocalization1.52272741
35MP0005389_reproductive_system_phenotype1.50193196
36MP0002653_abnormal_ependyma_morphology1.50029889
37MP0002420_abnormal_adaptive_immunity1.49734810
38MP0001819_abnormal_immune_cell1.45129361
39MP0005551_abnormal_eye_electrophysiolog1.44517553
40MP0001986_abnormal_taste_sensitivity1.39823870
41MP0008058_abnormal_DNA_repair1.38455255
42MP0002160_abnormal_reproductive_system1.38105332
43MP0005025_abnormal_response_to1.36569712
44MP0004885_abnormal_endolymph1.36255031
45MP0001919_abnormal_reproductive_system1.35228009
46MP0002736_abnormal_nociception_after1.34929745
47MP0004142_abnormal_muscle_tone1.33887568
48MP0005387_immune_system_phenotype1.33590510
49MP0001790_abnormal_immune_system1.33590510
50MP0005379_endocrine/exocrine_gland_phen1.32778402
51MP0002006_tumorigenesis1.28987224
52MP0003786_premature_aging1.26999144
53MP0002166_altered_tumor_susceptibility1.21973849
54MP0002398_abnormal_bone_marrow1.19659144
55MP0002452_abnormal_antigen_presenting1.19456287
56MP0000716_abnormal_immune_system1.15325452
57MP0002405_respiratory_system_inflammati1.14452458
58MP0002876_abnormal_thyroid_physiology1.14095161
59MP0001485_abnormal_pinna_reflex1.13559993
60MP0005646_abnormal_pituitary_gland1.13125766
61MP0006036_abnormal_mitochondrial_physio1.10200896
62MP0002095_abnormal_skin_pigmentation1.09446434
63MP0010155_abnormal_intestine_physiology1.08923935
64MP0001764_abnormal_homeostasis1.08711949
65MP0002277_abnormal_respiratory_mucosa1.07721421
66MP0001905_abnormal_dopamine_level1.06880550
67MP0000703_abnormal_thymus_morphology1.06778104
68MP0003011_delayed_dark_adaptation1.05980719
69MP0000689_abnormal_spleen_morphology1.03836342
70MP0002272_abnormal_nervous_system1.03415679
71MP0006276_abnormal_autonomic_nervous1.02061182
72MP0003195_calcinosis1.00778057
73MP0005253_abnormal_eye_physiology1.00520482
74MP0009764_decreased_sensitivity_to0.98692441
75MP0001542_abnormal_bone_strength0.98140561
76MP0001501_abnormal_sleep_pattern0.97628574
77MP0008995_early_reproductive_senescence0.97199101
78MP0002722_abnormal_immune_system0.95597932
79MP0001845_abnormal_inflammatory_respons0.92675607
80MP0005410_abnormal_fertilization0.91442773
81MP0003186_abnormal_redox_activity0.90671601
82MP0002429_abnormal_blood_cell0.88613803
83MP0003787_abnormal_imprinting0.87114865
84MP0004742_abnormal_vestibular_system0.84139518
85MP0003718_maternal_effect0.83350138
86MP0002638_abnormal_pupillary_reflex0.83012820
87MP0002234_abnormal_pharynx_morphology0.82824961
88MP0005636_abnormal_mineral_homeostasis0.81403265
89MP0002693_abnormal_pancreas_physiology0.80758205
90MP0008789_abnormal_olfactory_epithelium0.78785249
91MP0008469_abnormal_protein_level0.77678256
92MP0003567_abnormal_fetal_cardiomyocyte0.76868802
93MP0005332_abnormal_amino_acid0.76151769
94MP0005174_abnormal_tail_pigmentation0.74911235
95MP0003724_increased_susceptibility_to0.74615767
96MP0009745_abnormal_behavioral_response0.74375145
97MP0006082_CNS_inflammation0.72257366
98MP0000631_abnormal_neuroendocrine_gland0.67156740
99MP0001663_abnormal_digestive_system0.65731766
100MP0002733_abnormal_thermal_nociception0.64833439

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.98982184
2Mitochondrial inheritance (HP:0001427)3.94953962
3Aplastic anemia (HP:0001915)3.86186638
4IgG deficiency (HP:0004315)3.79014193
5Congenital stationary night blindness (HP:0007642)3.63531837
6Abnormal mitochondria in muscle tissue (HP:0008316)3.58569852
7Elevated erythrocyte sedimentation rate (HP:0003565)3.55953581
8Molar tooth sign on MRI (HP:0002419)3.49183665
9Abnormality of midbrain morphology (HP:0002418)3.49183665
10Increased CSF lactate (HP:0002490)3.47063939
11Pancreatic cysts (HP:0001737)3.44513001
12Acute encephalopathy (HP:0006846)3.40648961
13Severe combined immunodeficiency (HP:0004430)3.39408703
14Increased hepatocellular lipid droplets (HP:0006565)3.38022965
15Hepatocellular necrosis (HP:0001404)3.36401508
16Abnormality of B cell number (HP:0010975)3.23095260
17Progressive macrocephaly (HP:0004481)3.21590640
18Increased IgM level (HP:0003496)3.20473215
19Reticulocytopenia (HP:0001896)3.19770430
20Abnormality of cells of the erythroid lineage (HP:0012130)3.15509181
21Absent rod-and cone-mediated responses on ERG (HP:0007688)3.12820921
223-Methylglutaconic aciduria (HP:0003535)3.12159543
23Hepatic necrosis (HP:0002605)3.11108589
24Hypoproteinemia (HP:0003075)3.08094001
25Lipid accumulation in hepatocytes (HP:0006561)3.07369007
26True hermaphroditism (HP:0010459)3.04946587
27Increased intramyocellular lipid droplets (HP:0012240)3.03861321
28Pancreatic fibrosis (HP:0100732)3.03854577
29Abnormal number of erythroid precursors (HP:0012131)2.89013202
30Cerebral edema (HP:0002181)2.85050577
31Stomatitis (HP:0010280)2.84645778
32B lymphocytopenia (HP:0010976)2.77168120
33Renal Fanconi syndrome (HP:0001994)2.77065907
34Abnormal rod and cone electroretinograms (HP:0008323)2.72608119
35Thyroiditis (HP:0100646)2.70491365
36Abolished electroretinogram (ERG) (HP:0000550)2.65678082
37Abnormality of the renal cortex (HP:0011035)2.65606614
38Macrocytic anemia (HP:0001972)2.62532376
39Increased serum lactate (HP:0002151)2.60155891
40Abnormality of T cell number (HP:0011839)2.59857160
41Type II lissencephaly (HP:0007260)2.56660792
42Optic disc pallor (HP:0000543)2.55905160
43T lymphocytopenia (HP:0005403)2.53567922
44Combined immunodeficiency (HP:0005387)2.49159104
45Increased muscle lipid content (HP:0009058)2.48090252
46Renal cortical cysts (HP:0000803)2.44421873
47Abnormality of T cells (HP:0002843)2.44124966
48Abnormality of the prostate (HP:0008775)2.43628522
49Decreased activity of mitochondrial respiratory chain (HP:0008972)2.43335005
50Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.43335005
51Nephronophthisis (HP:0000090)2.41042798
52Lactic acidosis (HP:0003128)2.36883445
53Hyperglycinemia (HP:0002154)2.32876867
54Methylmalonic acidemia (HP:0002912)2.32225678
55Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.27881586
56Exertional dyspnea (HP:0002875)2.21100438
57Lethargy (HP:0001254)2.17661742
58Pancytopenia (HP:0001876)2.16157793
59Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.16134971
60Decreased electroretinogram (ERG) amplitude (HP:0000654)2.15763194
61Encephalitis (HP:0002383)2.15697105
62Congenital, generalized hypertrichosis (HP:0004540)2.14141991
63Panhypogammaglobulinemia (HP:0003139)2.09832232
64Medial flaring of the eyebrow (HP:0010747)2.09818660
65Autoimmune hemolytic anemia (HP:0001890)2.09717084
66Constricted visual fields (HP:0001133)2.09703615
67Stenosis of the external auditory canal (HP:0000402)2.07599534
68Glycosuria (HP:0003076)2.06017143
69Abnormality of urine glucose concentration (HP:0011016)2.06017143
70Prostate neoplasm (HP:0100787)2.05883425
71Abnormality of eosinophils (HP:0001879)2.03771866
72Methylmalonic aciduria (HP:0012120)2.03426048
73Abnormality of the renal medulla (HP:0100957)2.02862994
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02087941
75Abnormality of alanine metabolism (HP:0010916)2.02087941
76Hyperalaninemia (HP:0003348)2.02087941
77Ketosis (HP:0001946)2.01899568
78Pallor (HP:0000980)2.00044524
79Cystic liver disease (HP:0006706)2.00034571
80Type 2 muscle fiber atrophy (HP:0003554)1.98732726
81Sclerocornea (HP:0000647)1.94708477
82Abnormal delayed hypersensitivity skin test (HP:0002963)1.94560953
83Respiratory failure (HP:0002878)1.93871593
84Abnormality of T cell physiology (HP:0011840)1.93759752
85Colon cancer (HP:0003003)1.93381103
86Abnormal drinking behavior (HP:0030082)1.92644097
87Polydipsia (HP:0001959)1.92644097
88Cerebellar dysplasia (HP:0007033)1.92152422
89Stomach cancer (HP:0012126)1.91710318
90Tubular atrophy (HP:0000092)1.90130477
91Asplenia (HP:0001746)1.88955500
92Aplasia/Hypoplasia of the spleen (HP:0010451)1.88000042
93Abnormality of serine family amino acid metabolism (HP:0010894)1.87959022
94Abnormality of glycine metabolism (HP:0010895)1.87959022
95Leukodystrophy (HP:0002415)1.83935230
96Attenuation of retinal blood vessels (HP:0007843)1.82793426
97Pendular nystagmus (HP:0012043)1.82622127
98Abnormality of renal resorption (HP:0011038)1.80774727
99Muscle fiber atrophy (HP:0100295)1.80067462
100Respiratory difficulties (HP:0002880)1.79262970

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.54522682
2KDR3.42758452
3BCKDK3.18560439
4VRK23.06319859
5ZAK2.97430732
6MAP4K22.81476936
7ADRBK22.52993103
8TAOK32.47121982
9TLK12.31952824
10GRK12.17475149
11NUAK12.12564374
12PASK2.09885286
13WNK42.06684822
14PINK11.95102623
15VRK11.93120341
16CDK191.93024090
17MAP4K11.91340853
18TESK21.71136658
19MAP3K121.64793263
20EIF2AK31.64758569
21ITK1.60838062
22NME11.57277905
23SYK1.43452137
24GRK61.30651655
25MUSK1.28837326
26MST41.25378529
27TEC1.24011549
28DYRK21.22725079
29MAP2K61.22092715
30STK161.21168498
31WNK31.17818541
32SCYL21.16252239
33FRK1.15314572
34BMPR1B1.13446394
35TIE11.10382849
36FES1.10297540
37LIMK11.08375433
38INSRR1.06695910
39BUB11.05280128
40PRKCQ1.03746936
41BTK0.99036165
42IKBKB0.96972192
43LCK0.94454149
44KIT0.94249596
45STK390.93156373
46CAMKK20.91736040
47OXSR10.89545316
48TRIM280.89497449
49PBK0.81905187
50CSF1R0.80450746
51DAPK10.79448843
52LYN0.76357776
53TAF10.75287849
54GRK70.73612327
55RPS6KA40.71728043
56RPS6KA50.70547636
57CSK0.63765304
58MAP3K110.63576842
59BMPR20.62280403
60ZAP700.61758944
61ADRBK10.61722554
62PIK3CG0.58673359
63IKBKE0.55857943
64FLT30.54320630
65MYLK0.53756847
66IGF1R0.52984429
67SRPK10.51110174
68PIM10.49873288
69CSNK2A20.47797291
70CSNK1G30.47489542
71MAPKAPK30.47021453
72DAPK30.46709453
73CAMKK10.46038222
74PIK3CA0.45934066
75OBSCN0.44639837
76PRKCE0.44106102
77MAPK130.43582424
78CSNK2A10.43534022
79PLK30.43385782
80PRKACA0.41931556
81PRKCA0.40817110
82PLK40.40770728
83TSSK60.40734291
84ATR0.38606213
85EIF2AK20.38275277
86MAP3K40.38092021
87AURKB0.38061569
88PRKCG0.35295480
89NEK10.34330552
90CSNK1G10.32715528
91PRKCH0.32470222
92PHKG20.31832402
93PHKG10.31832402
94CSNK1G20.31694686
95HCK0.31677495
96AURKA0.30848087
97JAK30.29810337
98MAP3K50.28588684
99RPS6KA60.28316768
100DAPK20.27015179

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.24448938
2Proteasome_Homo sapiens_hsa030504.01788531
3Primary immunodeficiency_Homo sapiens_hsa053403.65611119
4Oxidative phosphorylation_Homo sapiens_hsa001903.64368406
5Parkinsons disease_Homo sapiens_hsa050122.97313612
6RNA polymerase_Homo sapiens_hsa030202.60516296
7Allograft rejection_Homo sapiens_hsa053302.43247756
8Autoimmune thyroid disease_Homo sapiens_hsa053202.37512861
9Graft-versus-host disease_Homo sapiens_hsa053322.26004028
10Asthma_Homo sapiens_hsa053102.24532329
11Protein export_Homo sapiens_hsa030602.15351908
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.09712148
13Type I diabetes mellitus_Homo sapiens_hsa049402.00900222
14Huntingtons disease_Homo sapiens_hsa050161.95720236
15Alzheimers disease_Homo sapiens_hsa050101.90950058
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.79628717
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.79096915
18Antigen processing and presentation_Homo sapiens_hsa046121.75054896
19Cardiac muscle contraction_Homo sapiens_hsa042601.70765403
20Linoleic acid metabolism_Homo sapiens_hsa005911.68553865
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65485231
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.64529004
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63199733
24RNA degradation_Homo sapiens_hsa030181.61845567
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.59897155
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58082316
27Hematopoietic cell lineage_Homo sapiens_hsa046401.50693180
28Phototransduction_Homo sapiens_hsa047441.49408326
29Nitrogen metabolism_Homo sapiens_hsa009101.26610268
30Pyrimidine metabolism_Homo sapiens_hsa002401.25486671
31One carbon pool by folate_Homo sapiens_hsa006701.23550472
32Homologous recombination_Homo sapiens_hsa034401.23349008
33Butanoate metabolism_Homo sapiens_hsa006501.19285117
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17168802
35Propanoate metabolism_Homo sapiens_hsa006401.12586682
36Rheumatoid arthritis_Homo sapiens_hsa053231.10282960
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10192564
38Basal transcription factors_Homo sapiens_hsa030221.09814077
39T cell receptor signaling pathway_Homo sapiens_hsa046601.08248937
40Peroxisome_Homo sapiens_hsa041461.02498979
41Purine metabolism_Homo sapiens_hsa002301.00101305
42Caffeine metabolism_Homo sapiens_hsa002320.96179274
43Fanconi anemia pathway_Homo sapiens_hsa034600.95640251
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92313124
45Spliceosome_Homo sapiens_hsa030400.91336085
46RNA transport_Homo sapiens_hsa030130.88368756
47Ether lipid metabolism_Homo sapiens_hsa005650.79994880
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77808313
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.77797035
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76906795
51Tryptophan metabolism_Homo sapiens_hsa003800.74185083
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71788444
53Arachidonic acid metabolism_Homo sapiens_hsa005900.71723216
54Base excision repair_Homo sapiens_hsa034100.71671094
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70768285
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.70300519
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68685840
58Viral myocarditis_Homo sapiens_hsa054160.67424436
59Chemical carcinogenesis_Homo sapiens_hsa052040.67014933
60Regulation of autophagy_Homo sapiens_hsa041400.66508076
61Nucleotide excision repair_Homo sapiens_hsa034200.65056560
62Retinol metabolism_Homo sapiens_hsa008300.64800326
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64794567
64Olfactory transduction_Homo sapiens_hsa047400.63582293
65Metabolic pathways_Homo sapiens_hsa011000.60937460
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60781272
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60757588
68DNA replication_Homo sapiens_hsa030300.60608091
69Mismatch repair_Homo sapiens_hsa034300.56837089
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.55701688
71Sulfur metabolism_Homo sapiens_hsa009200.55294170
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52368882
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52162263
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51058577
75Non-homologous end-joining_Homo sapiens_hsa034500.50781821
76Fat digestion and absorption_Homo sapiens_hsa049750.50756803
77Systemic lupus erythematosus_Homo sapiens_hsa053220.50663156
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.49030315
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45990128
80Collecting duct acid secretion_Homo sapiens_hsa049660.43077785
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41120366
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39696595
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.37619538
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.36810291
85Measles_Homo sapiens_hsa051620.36625992
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35482723
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33506359
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.33349222
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32632717
90Herpes simplex infection_Homo sapiens_hsa051680.28521849
91Nicotine addiction_Homo sapiens_hsa050330.28403414
92Fatty acid degradation_Homo sapiens_hsa000710.27235763
93Selenocompound metabolism_Homo sapiens_hsa004500.26897322
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25333083
95Sulfur relay system_Homo sapiens_hsa041220.24950340
96Epstein-Barr virus infection_Homo sapiens_hsa051690.24857849
97Shigellosis_Homo sapiens_hsa051310.21072761
98Taste transduction_Homo sapiens_hsa047420.20868741
99Fatty acid elongation_Homo sapiens_hsa000620.20564016
100Malaria_Homo sapiens_hsa051440.20448880

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