ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	5.73907982
2	viral transcription (GO:0019083)	5.45654160
3	translational termination (GO:0006415)	5.34073286
4	maturation of SSU-rRNA (GO:0030490)	5.11460978
5	ribosomal small subunit assembly (GO:0000028)	5.01637632
6	translational elongation (GO:0006414)	4.61761834
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.60009882
8	cotranslational protein targeting to membrane (GO:0006613)	4.48753529
9	protein targeting to ER (GO:0045047)	4.45390082
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.26776825
11	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	4.23548469
12	protein localization to endoplasmic reticulum (GO:0070972)	4.20992930
13	chaperone-mediated protein transport (GO:0072321)	4.13272144
14	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	4.12992463
15	viral life cycle (GO:0019058)	4.03017258
16	translational initiation (GO:0006413)	4.02366234
17	cellular protein complex disassembly (GO:0043624)	3.96068341
18	GTP biosynthetic process (GO:0006183)	3.94172682
19	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.92298763
20	ribonucleoprotein complex biogenesis (GO:0022613)	3.86329600
21	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.85518362
22	ribosomal large subunit biogenesis (GO:0042273)	3.80136558
23	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.77635932
24	NADH dehydrogenase complex assembly (GO:0010257)	3.77635932
25	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.77635932
26	rRNA modification (GO:0000154)	3.68588751
27	translation (GO:0006412)	3.65597387
28	cellular component biogenesis (GO:0044085)	3.64687229
29	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.63560483
30	substrate-independent telencephalic tangential migration (GO:0021826)	3.63560483
31	peptidyl-histidine modification (GO:0018202)	3.62407800
32	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.59744087
33	ATP synthesis coupled proton transport (GO:0015986)	3.59744087
34	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.59533686
35	rRNA metabolic process (GO:0016072)	3.42101146
36	protein-cofactor linkage (GO:0018065)	3.41382660
37	DNA deamination (GO:0045006)	3.41235643
38	rRNA processing (GO:0006364)	3.39837150
39	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.38721327
40	UTP biosynthetic process (GO:0006228)	3.38116079
41	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.37025011
42	nonmotile primary cilium assembly (GO:0035058)	3.31312924
43	protein complex disassembly (GO:0043241)	3.29267170
44	ribosome biogenesis (GO:0042254)	3.29174346
45	epithelial cilium movement (GO:0003351)	3.27447204
46	mRNA catabolic process (GO:0006402)	3.20273107
47	mitochondrial respiratory chain complex assembly (GO:0033108)	3.18861113
48	piRNA metabolic process (GO:0034587)	3.18021052
49	heparin biosynthetic process (GO:0030210)	3.15928635
50	heparin metabolic process (GO:0030202)	3.15928635
51	protein complex biogenesis (GO:0070271)	3.15689573
52	rRNA catabolic process (GO:0016075)	3.13007546
53	macromolecular complex disassembly (GO:0032984)	3.12814925
54	termination of RNA polymerase III transcription (GO:0006386)	3.12789021
55	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.12789021
56	regulation of chronic inflammatory response (GO:0002676)	3.10010600
57	resolution of meiotic recombination intermediates (GO:0000712)	3.06045111
58	base-excision repair, AP site formation (GO:0006285)	3.03142693
59	auditory receptor cell differentiation (GO:0042491)	3.02169899
60	kinetochore assembly (GO:0051382)	3.01306930
61	CTP metabolic process (GO:0046036)	2.96658654
62	CTP biosynthetic process (GO:0006241)	2.96658654
63	UTP metabolic process (GO:0046051)	2.94808759
64	DNA methylation involved in gamete generation (GO:0043046)	2.93867983
65	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.93825417
66	RNA catabolic process (GO:0006401)	2.92352698
67	protein targeting to membrane (GO:0006612)	2.92087292
68	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.89572542
69	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.89572542
70	purine deoxyribonucleotide catabolic process (GO:0009155)	2.89215574
71	rRNA methylation (GO:0031167)	2.88929729
72	termination of RNA polymerase I transcription (GO:0006363)	2.88084780
73	striatum development (GO:0021756)	2.87999447
74	tRNA processing (GO:0008033)	2.85724296
75	dopamine transport (GO:0015872)	2.80682869
76	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.80545024
77	pseudouridine synthesis (GO:0001522)	2.77331833
78	protein targeting to mitochondrion (GO:0006626)	2.75083379
79	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.74922527
80	male meiosis I (GO:0007141)	2.71429126
81	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.68774424
82	ncRNA processing (GO:0034470)	2.67893452
83	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.67257585
84	purine nucleotide salvage (GO:0032261)	2.63474944
85	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.61590775
86	kinetochore organization (GO:0051383)	2.61485069
87	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.60881442
88	male meiosis (GO:0007140)	2.60794339
89	intracellular protein transmembrane import (GO:0044743)	2.60569563
90	protein localization to mitochondrion (GO:0070585)	2.59912194
91	snRNA transcription (GO:0009301)	2.56552960
92	mitochondrial RNA metabolic process (GO:0000959)	2.56519303
93	ncRNA metabolic process (GO:0034660)	2.54934716
94	positive regulation of DNA recombination (GO:0045911)	2.54639332
95	establishment of protein localization to mitochondrion (GO:0072655)	2.53955268
96	ubiquinone biosynthetic process (GO:0006744)	2.53909852
97	regulation of cilium movement (GO:0003352)	2.53876406
98	kynurenine metabolic process (GO:0070189)	2.53272571
99	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.52923604
100	positive regulation of amino acid transport (GO:0051957)	2.52738724

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.65139894
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	5.12874147
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.57151993
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	4.04352551
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.52509420
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.49906026
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.34811084
8	VDR_23849224_ChIP-Seq_CD4+_Human	3.02786913
9	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.01876726
10	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.93403756
11	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.82397846
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.79794589
13	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.61899769
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.48439794
15	FOXP3_21729870_ChIP-Seq_TREG_Human	2.41553175
16	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.34314121
17	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.20759005
18	GABP_19822575_ChIP-Seq_HepG2_Human	2.17462774
19	TTF2_22483619_ChIP-Seq_HELA_Human	2.12385819
20	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	2.04726640
21	IRF1_19129219_ChIP-ChIP_H3396_Human	2.04261329
22	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.01790288
23	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.97236096
24	ZNF274_21170338_ChIP-Seq_K562_Hela	1.96905535
25	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.92241787
26	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.89309824
27	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.88583969
28	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.84246209
29	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.84040002
30	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.83881087
31	XRN2_22483619_ChIP-Seq_HELA_Human	1.78866535
32	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.75517859
33	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.69892609
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.68090915
35	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.63337346
36	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.58405811
37	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.55925930
38	DCP1A_22483619_ChIP-Seq_HELA_Human	1.52426059
39	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.50216579
40	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.49848263
41	EZH2_22144423_ChIP-Seq_EOC_Human	1.47618401
42	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.45862175
43	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.44487278
44	VDR_22108803_ChIP-Seq_LS180_Human	1.43231737
45	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.37289999
46	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.36405132
47	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.36391392
48	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.34413487
49	KDM5A_27292631_Chip-Seq_BREAST_Human	1.33260068
50	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.32997650
51	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.32347725
52	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.28524665
53	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.27650670
54	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.26022590
55	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.25858612
56	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.25583656
57	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.24241047
58	EWS_26573619_Chip-Seq_HEK293_Human	1.24232670
59	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.23527125
60	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23404304
61	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.21126098
62	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.21013529
63	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.20554175
64	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.19124951
65	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.17157486
66	TP53_22573176_ChIP-Seq_HFKS_Human	1.17084494
67	GATA3_26560356_Chip-Seq_TH2_Human	1.16633022
68	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.15174038
69	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.15138717
70	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.12305867
71	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.10204275
72	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.09854354
73	CIITA_25753668_ChIP-Seq_RAJI_Human	1.07953691
74	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.06938469
75	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.05139394
76	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.01400017
77	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.00057493
78	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.99492255
79	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.99054616
80	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.98289136
81	NCOR_22424771_ChIP-Seq_293T_Human	0.97325856
82	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.97145782
83	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.96916404
84	E2F7_22180533_ChIP-Seq_HELA_Human	0.94331702
85	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.93121128
86	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.93062018
87	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.88906619
88	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.87222041
89	ERA_21632823_ChIP-Seq_H3396_Human	0.86074707
90	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.85742503
91	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.85393120
92	RBPJ_21746931_ChIP-Seq_IB4_Human	0.85013121
93	NANOG_20526341_ChIP-Seq_ESCs_Human	0.80339144
94	HOXB7_26014856_ChIP-Seq_BT474_Human	0.80130540
95	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.80074321
96	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.79911890
97	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.77380206
98	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.77333380
99	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.76648687
100	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.76643670

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.48852085
2	MP0008877_abnormal_DNA_methylation	3.75644643
3	MP0002163_abnormal_gland_morphology	3.53186378
4	MP0009379_abnormal_foot_pigmentation	3.01494557
5	MP0005379_endocrine/exocrine_gland_phen	2.81876445
6	MP0003646_muscle_fatigue	2.61382992
7	MP0008789_abnormal_olfactory_epithelium	2.49043591
8	MP0000372_irregular_coat_pigmentation	2.47166883
9	MP0002102_abnormal_ear_morphology	2.44823808
10	MP0003123_paternal_imprinting	2.42596777
11	MP0003787_abnormal_imprinting	2.32806326
12	MP0001835_abnormal_antigen_presentation	2.26727690
13	MP0003011_delayed_dark_adaptation	2.23147119
14	MP0000685_abnormal_immune_system	2.19574268
15	MP0005499_abnormal_olfactory_system	2.17234747
16	MP0005394_taste/olfaction_phenotype	2.17234747
17	MP0008058_abnormal_DNA_repair	2.04130027
18	MP0003186_abnormal_redox_activity	1.92277839
19	MP0006036_abnormal_mitochondrial_physio	1.91653930
20	MP0002138_abnormal_hepatobiliary_system	1.80377311
21	MP0003718_maternal_effect	1.71210118
22	MP0002837_dystrophic_cardiac_calcinosis	1.69926156
23	MP0003121_genomic_imprinting	1.66876585
24	MP0009697_abnormal_copulation	1.59971369
25	MP0004142_abnormal_muscle_tone	1.57544485
26	MP0001764_abnormal_homeostasis	1.50005831
27	MP0001800_abnormal_humoral_immune	1.46921103
28	MP0005174_abnormal_tail_pigmentation	1.46723441
29	MP0003693_abnormal_embryo_hatching	1.44652137
30	MP0001986_abnormal_taste_sensitivity	1.44392311
31	MP0003786_premature_aging	1.44380328
32	MP0002653_abnormal_ependyma_morphology	1.38944469
33	MP0003122_maternal_imprinting	1.37658276
34	MP0001293_anophthalmia	1.35244359
35	MP0009764_decreased_sensitivity_to	1.33954919
36	MP0001790_abnormal_immune_system	1.33498643
37	MP0005387_immune_system_phenotype	1.33498643
38	MP0001968_abnormal_touch/_nociception	1.32828683
39	MP0002938_white_spotting	1.27553501
40	MP0005671_abnormal_response_to	1.23612201
41	MP0002210_abnormal_sex_determination	1.23305367
42	MP0002095_abnormal_skin_pigmentation	1.22407746
43	MP0005167_abnormal_blood-brain_barrier	1.21434173
44	MP0005551_abnormal_eye_electrophysiolog	1.21349604
45	MP0006035_abnormal_mitochondrial_morpho	1.18421822
46	MP0006072_abnormal_retinal_apoptosis	1.18206846
47	MP0001529_abnormal_vocalization	1.13439837
48	MP0003724_increased_susceptibility_to	1.11148694
49	MP0002148_abnormal_hypersensitivity_rea	1.05873290
50	MP0008057_abnormal_DNA_replication	1.04544642
51	MP0000569_abnormal_digit_pigmentation	1.02511207
52	MP0003111_abnormal_nucleus_morphology	1.02487677
53	MP0005075_abnormal_melanosome_morpholog	1.02142278
54	MP0005310_abnormal_salivary_gland	1.01739963
55	MP0002723_abnormal_immune_serum	1.00536432
56	MP0005253_abnormal_eye_physiology	1.00528081
57	MP0005389_reproductive_system_phenotype	1.00503281
58	MP0001929_abnormal_gametogenesis	0.99792232
59	MP0002736_abnormal_nociception_after	0.99668140
60	MP0003436_decreased_susceptibility_to	0.95661345
61	MP0003077_abnormal_cell_cycle	0.95600281
62	MP0000427_abnormal_hair_cycle	0.94249618
63	MP0002160_abnormal_reproductive_system	0.93762328
64	MP0000653_abnormal_sex_gland	0.91472068
65	MP0002452_abnormal_antigen_presenting	0.90347681
66	MP0002405_respiratory_system_inflammati	0.90335344
67	MP0001905_abnormal_dopamine_level	0.90089631
68	MP0001501_abnormal_sleep_pattern	0.89951314
69	MP0005000_abnormal_immune_tolerance	0.89425360
70	MP0008875_abnormal_xenobiotic_pharmacok	0.88807155
71	MP0005408_hypopigmentation	0.88076932
72	MP0008932_abnormal_embryonic_tissue	0.86142866
73	MP0005084_abnormal_gallbladder_morpholo	0.84907880
74	MP0004957_abnormal_blastocyst_morpholog	0.84148264
75	MP0000358_abnormal_cell_content/	0.83803241
76	MP0001145_abnormal_male_reproductive	0.83655737
77	MP0001119_abnormal_female_reproductive	0.80982115
78	MP0010094_abnormal_chromosome_stability	0.79824446
79	MP0001984_abnormal_olfaction	0.79298979
80	MP0005377_hearing/vestibular/ear_phenot	0.79284201
81	MP0003878_abnormal_ear_physiology	0.79284201
82	MP0001919_abnormal_reproductive_system	0.79212036
83	MP0005195_abnormal_posterior_eye	0.78848447
84	MP0002277_abnormal_respiratory_mucosa	0.78669635
85	MP0006276_abnormal_autonomic_nervous	0.78515543
86	MP0002420_abnormal_adaptive_immunity	0.77571733
87	MP0000371_diluted_coat_color	0.76582522
88	MP0005391_vision/eye_phenotype	0.75680698
89	MP0000689_abnormal_spleen_morphology	0.74834880
90	MP0001819_abnormal_immune_cell	0.73816497
91	MP0009333_abnormal_splenocyte_physiolog	0.70047276
92	MP0001286_abnormal_eye_development	0.69284515
93	MP0000613_abnormal_salivary_gland	0.69165107
94	MP0004019_abnormal_vitamin_homeostasis	0.66541074
95	MP0009765_abnormal_xenobiotic_induced	0.66339688
96	MP0005645_abnormal_hypothalamus_physiol	0.65498867
97	MP0001324_abnormal_eye_pigmentation	0.64973389
98	MP0002722_abnormal_immune_system	0.64424933
99	MP0000015_abnormal_ear_pigmentation	0.64397894
100	MP0003567_abnormal_fetal_cardiomyocyte	0.63900412

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.57293282
2	Pancreatic fibrosis (HP:0100732)	4.20341619
3	Reticulocytopenia (HP:0001896)	4.02548849
4	Abnormal mitochondria in muscle tissue (HP:0008316)	3.95578015
5	Acute encephalopathy (HP:0006846)	3.87013803
6	Progressive macrocephaly (HP:0004481)	3.58249570
7	Stomatitis (HP:0010280)	3.47082631
8	Pancreatic cysts (HP:0001737)	3.40953460
9	Molar tooth sign on MRI (HP:0002419)	3.31595359
10	Abnormality of midbrain morphology (HP:0002418)	3.31595359
11	Increased CSF lactate (HP:0002490)	3.25436034
12	Mitochondrial inheritance (HP:0001427)	3.13909674
13	True hermaphroditism (HP:0010459)	3.12424863
14	3-Methylglutaconic aciduria (HP:0003535)	3.09201693
15	Abnormality of DNA repair (HP:0003254)	3.07475506
16	Abnormality of cells of the erythroid lineage (HP:0012130)	3.00325422
17	Cerebral edema (HP:0002181)	2.98608029
18	Abnormality of alanine metabolism (HP:0010916)	2.97787203
19	Hyperalaninemia (HP:0003348)	2.97787203
20	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.97787203
21	Rib fusion (HP:0000902)	2.81916938
22	Macrocytic anemia (HP:0001972)	2.74294363
23	Hepatocellular necrosis (HP:0001404)	2.68241282
24	Hepatic necrosis (HP:0002605)	2.67001517
25	Diastasis recti (HP:0001540)	2.65517221
26	Medial flaring of the eyebrow (HP:0010747)	2.60810525
27	Pallor (HP:0000980)	2.56512833
28	Arthropathy (HP:0003040)	2.55162120
29	Increased serum lactate (HP:0002151)	2.51315674
30	Optic disc pallor (HP:0000543)	2.50191471
31	Submucous cleft hard palate (HP:0000176)	2.42133296
32	Congenital stationary night blindness (HP:0007642)	2.39667411
33	Supernumerary spleens (HP:0009799)	2.38584736
34	Methylmalonic acidemia (HP:0002912)	2.37742200
35	Tubulointerstitial nephritis (HP:0001970)	2.36853835
36	Nephronophthisis (HP:0000090)	2.32796493
37	Absent thumb (HP:0009777)	2.32717945
38	Entropion (HP:0000621)	2.30499919
39	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.29363739
40	Exertional dyspnea (HP:0002875)	2.25832147
41	Abnormal number of erythroid precursors (HP:0012131)	2.24302399
42	Microvesicular hepatic steatosis (HP:0001414)	2.21582531
43	Bile duct proliferation (HP:0001408)	2.20101425
44	Abnormal biliary tract physiology (HP:0012439)	2.20101425
45	Anencephaly (HP:0002323)	2.19892470
46	Abnormality of T cell physiology (HP:0011840)	2.17543239
47	Peritonitis (HP:0002586)	2.17228110
48	Gastrointestinal infarctions (HP:0005244)	2.15285748
49	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.14923175
50	Abnormality of the renal medulla (HP:0100957)	2.12392602
51	Type II lissencephaly (HP:0007260)	2.09648728
52	Agammaglobulinemia (HP:0004432)	2.09213573
53	Lactic acidosis (HP:0003128)	2.07522435
54	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.07017685
55	Cystic liver disease (HP:0006706)	2.06488326
56	Abnormality of the renal cortex (HP:0011035)	2.06302022
57	Tubular atrophy (HP:0000092)	2.05970772
58	Abnormal rod and cone electroretinograms (HP:0008323)	2.05389304
59	Colon cancer (HP:0003003)	2.04467876
60	Methylmalonic aciduria (HP:0012120)	2.03620484
61	Oligodactyly (HP:0012165)	2.01609489
62	Congenital primary aphakia (HP:0007707)	1.99748428
63	Leukodystrophy (HP:0002415)	1.98337553
64	IgG deficiency (HP:0004315)	1.97820486
65	Ectopic kidney (HP:0000086)	1.94704179
66	Microretrognathia (HP:0000308)	1.94480395
67	Septo-optic dysplasia (HP:0100842)	1.94012204
68	Postaxial foot polydactyly (HP:0001830)	1.94011553
69	Oligodactyly (hands) (HP:0001180)	1.93993570
70	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.91310850
71	Hyperglycinemia (HP:0002154)	1.91011577
72	Gait imbalance (HP:0002141)	1.87485040
73	Thrombocytosis (HP:0001894)	1.87412562
74	Neutropenia (HP:0001875)	1.86796923
75	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.83949451
76	Panhypogammaglobulinemia (HP:0003139)	1.82961903
77	Poor coordination (HP:0002370)	1.82564839
78	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.81795764
79	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.81795764
80	Lethargy (HP:0001254)	1.81659454
81	Adrenal hypoplasia (HP:0000835)	1.79696694
82	Optic nerve coloboma (HP:0000588)	1.77430713
83	Nephrogenic diabetes insipidus (HP:0009806)	1.76271130
84	Increased IgM level (HP:0003496)	1.75925106
85	Growth hormone deficiency (HP:0000824)	1.73856992
86	Abnormality of the ileum (HP:0001549)	1.72799358
87	Poikiloderma (HP:0001029)	1.72082604
88	Abnormality of the pons (HP:0007361)	1.71884627
89	Meckel diverticulum (HP:0002245)	1.71259846
90	Hypoplasia of the pons (HP:0012110)	1.70678862
91	Pancytopenia (HP:0001876)	1.69536489
92	Elevated erythrocyte sedimentation rate (HP:0003565)	1.69278561
93	Sclerocornea (HP:0000647)	1.68050176
94	Respiratory failure (HP:0002878)	1.67764332
95	Duplicated collecting system (HP:0000081)	1.67289082
96	Fatigue (HP:0012378)	1.66113414
97	Acute hepatic failure (HP:0006554)	1.65962679
98	Abnormality of the renal collecting system (HP:0004742)	1.65352954
99	11 pairs of ribs (HP:0000878)	1.63781598
100	Pachygyria (HP:0001302)	1.63391747

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	4.42780320
2	CAMKK2	4.10676474
3	BRSK2	3.06287647
4	NUAK1	2.77976156
5	CAMK1D	2.63243989
6	TRIM28	2.60368550
7	STK16	2.53165745
8	PDK2	2.50719435
9	CASK	2.45533493
10	JAK3	2.43098394
11	ADRBK2	2.35350456
12	TLK1	2.26713562
13	ZAK	2.20643861
14	NME2	2.12475135
15	WNK4	2.08261375
16	GRK1	2.03177024
17	EIF2AK3	1.95178218
18	BMPR1B	1.74331413
19	CDK8	1.74310776
20	CAMK1G	1.67960045
21	INSRR	1.61034110
22	BRSK1	1.54384390
23	LRRK2	1.50747148
24	CAMKK1	1.46701553
25	TAF1	1.35976268
26	DYRK2	1.31180487
27	ACVR1B	1.24887240
28	TXK	1.23321454
29	KSR1	1.21258832
30	MATK	1.20949791
31	STK39	1.15153062
32	IKBKB	1.12013531
33	WNK1	1.07944369
34	BUB1	1.03963475
35	EIF2AK1	1.00808076
36	FRK	0.97945028
37	TEC	0.96596665
38	PAK3	0.96590436
39	DYRK3	0.93639330
40	PIM1	0.92721370
41	MARK3	0.90208620
42	CDC7	0.89767806
43	WNK3	0.86504023
44	ARAF	0.86351369
45	PLK1	0.79893926
46	BRAF	0.76654679
47	PRKCI	0.76295879
48	IRAK4	0.75133445
49	MAP3K12	0.73045515
50	PLK2	0.72390144
51	STK3	0.71857613
52	MAP3K14	0.71131306
53	GRK6	0.70444879
54	MKNK2	0.69999877
55	IKBKE	0.69786149
56	STK11	0.68237487
57	PLK4	0.67066259
58	BCKDK	0.66566230
59	NME1	0.66382993
60	MAP3K13	0.65477411
61	MST4	0.64707499
62	BTK	0.64182729
63	PTK2B	0.64110183
64	MAP3K11	0.63172099
65	TIE1	0.62956525
66	RAF1	0.62183752
67	CHEK1	0.60546365
68	PRKAA2	0.60157456
69	PLK3	0.57325247
70	PRKCQ	0.55962137
71	SRPK1	0.54083853
72	AURKB	0.53788804
73	OXSR1	0.53745498
74	PIM2	0.51845053
75	MARK2	0.50598252
76	CAMK4	0.50120366
77	PIK3CG	0.49122655
78	MAP3K9	0.48925506
79	AURKA	0.46519253
80	GRK5	0.46125132
81	IRAK3	0.44778126
82	EIF2AK2	0.44407657
83	SYK	0.43702657
84	LYN	0.42431549
85	TRPM7	0.42353011
86	CHEK2	0.41197034
87	MUSK	0.40872420
88	TGFBR1	0.39900460
89	CSNK2A2	0.39835813
90	ITK	0.39534665
91	VRK1	0.39237544
92	MAP4K2	0.38076160
93	PASK	0.37222911
94	MAP4K1	0.37134539
95	BLK	0.36166425
96	CSK	0.34811171
97	ATR	0.33383649
98	BMX	0.32953493
99	CSNK2A1	0.32383084
100	STK4	0.32078557

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.70147987
2	RNA polymerase_Homo sapiens_hsa03020	3.34743732
3	Basal transcription factors_Homo sapiens_hsa03022	3.13140643
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.98969165
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.93749302
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.92244056
7	Proteasome_Homo sapiens_hsa03050	2.91488554
8	Parkinsons disease_Homo sapiens_hsa05012	2.77735865
9	Protein export_Homo sapiens_hsa03060	2.76143333
10	Fanconi anemia pathway_Homo sapiens_hsa03460	2.42467689
11	RNA degradation_Homo sapiens_hsa03018	2.37765259
12	Homologous recombination_Homo sapiens_hsa03440	2.30676265
13	Huntingtons disease_Homo sapiens_hsa05016	2.06332249
14	Nucleotide excision repair_Homo sapiens_hsa03420	2.05747845
15	Mismatch repair_Homo sapiens_hsa03430	1.91125298
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.88816556
17	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.86325611
18	DNA replication_Homo sapiens_hsa03030	1.80844787
19	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.74388902
20	Pyrimidine metabolism_Homo sapiens_hsa00240	1.73503585
21	Asthma_Homo sapiens_hsa05310	1.72982067
22	Primary immunodeficiency_Homo sapiens_hsa05340	1.69032865
23	RNA transport_Homo sapiens_hsa03013	1.65743647
24	Regulation of autophagy_Homo sapiens_hsa04140	1.56276062
25	Base excision repair_Homo sapiens_hsa03410	1.53141005
26	Alzheimers disease_Homo sapiens_hsa05010	1.42533263
27	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.38246756
28	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.30764470
29	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.29913688
30	Steroid biosynthesis_Homo sapiens_hsa00100	1.27283654
31	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.25844886
32	Spliceosome_Homo sapiens_hsa03040	1.21847936
33	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.14892028
34	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.14221975
35	Linoleic acid metabolism_Homo sapiens_hsa00591	1.13520762
36	Cardiac muscle contraction_Homo sapiens_hsa04260	1.06192604
37	Purine metabolism_Homo sapiens_hsa00230	1.03585324
38	Sulfur metabolism_Homo sapiens_hsa00920	0.93780225
39	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.85784438
40	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.84426076
41	p53 signaling pathway_Homo sapiens_hsa04115	0.83694583
42	One carbon pool by folate_Homo sapiens_hsa00670	0.78668973
43	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.78437328
44	Peroxisome_Homo sapiens_hsa04146	0.77249125
45	Phototransduction_Homo sapiens_hsa04744	0.76672568
46	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.74865597
47	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.74582922
48	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.74550959
49	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.73823029
50	Cell cycle_Homo sapiens_hsa04110	0.72226274
51	Sulfur relay system_Homo sapiens_hsa04122	0.71855367
52	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.68792497
53	Allograft rejection_Homo sapiens_hsa05330	0.67681678
54	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.67291137
55	Propanoate metabolism_Homo sapiens_hsa00640	0.66414984
56	Measles_Homo sapiens_hsa05162	0.62895913
57	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.60460942
58	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.57234910
59	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.56218881
60	Folate biosynthesis_Homo sapiens_hsa00790	0.54853906
61	Selenocompound metabolism_Homo sapiens_hsa00450	0.54419023
62	Herpes simplex infection_Homo sapiens_hsa05168	0.51686517
63	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.51205603
64	mRNA surveillance pathway_Homo sapiens_hsa03015	0.51161879
65	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.50190314
66	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.48659783
67	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.48636138
68	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.48613835
69	Collecting duct acid secretion_Homo sapiens_hsa04966	0.48300020
70	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.47406787
71	Metabolic pathways_Homo sapiens_hsa01100	0.45354026
72	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.44029887
73	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.42782459
74	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.42566568
75	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.41711499
76	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.40838839
77	TNF signaling pathway_Homo sapiens_hsa04668	0.40785170
78	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.40309714
79	Nitrogen metabolism_Homo sapiens_hsa00910	0.39150154
80	Leishmaniasis_Homo sapiens_hsa05140	0.37333423
81	Apoptosis_Homo sapiens_hsa04210	0.36327880
82	Malaria_Homo sapiens_hsa05144	0.35271850
83	Ether lipid metabolism_Homo sapiens_hsa00565	0.33792917
84	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.33573521
85	Tuberculosis_Homo sapiens_hsa05152	0.33383570
86	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.31733336
87	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.30745658
88	Basal cell carcinoma_Homo sapiens_hsa05217	0.28799471
89	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.26012514
90	Legionellosis_Homo sapiens_hsa05134	0.23609409
91	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.23570821
92	Influenza A_Homo sapiens_hsa05164	0.21236789
93	Chemokine signaling pathway_Homo sapiens_hsa04062	0.18008246
94	Notch signaling pathway_Homo sapiens_hsa04330	0.17598187
95	Hepatitis C_Homo sapiens_hsa05160	0.17040564
96	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.16879909
97	Viral carcinogenesis_Homo sapiens_hsa05203	0.16199331
98	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.15251298
99	Prolactin signaling pathway_Homo sapiens_hsa04917	0.14971430
100	Caffeine metabolism_Homo sapiens_hsa00232	0.14301638

RPL4P6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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