ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	* viral transcription (GO:0019083)	9.94259650
2	* translational termination (GO:0006415)	9.59865438
3	ribosomal small subunit biogenesis (GO:0042274)	8.87265440
4	ribosomal small subunit assembly (GO:0000028)	8.30859607
5	* translational elongation (GO:0006414)	8.04367204
6	* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	8.01435461
7	maturation of SSU-rRNA (GO:0030490)	7.97669291
8	* cotranslational protein targeting to membrane (GO:0006613)	7.86797517
9	* protein targeting to ER (GO:0045047)	7.86773099
10	* establishment of protein localization to endoplasmic reticulum (GO:0072599)	7.53041929
11	* cellular protein complex disassembly (GO:0043624)	7.50518736
12	* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	7.37618262
13	* viral life cycle (GO:0019058)	7.36480135
14	* protein localization to endoplasmic reticulum (GO:0070972)	7.32953640
15	* translational initiation (GO:0006413)	7.11286902
16	* ribosomal large subunit biogenesis (GO:0042273)	6.86801277
17	* protein complex disassembly (GO:0043241)	6.53189745
18	* macromolecular complex disassembly (GO:0032984)	6.16411026
19	* nuclear-transcribed mRNA catabolic process (GO:0000956)	5.21402588
20	* protein targeting to membrane (GO:0006612)	5.16612181
21	* translation (GO:0006412)	5.10406292
22	* mRNA catabolic process (GO:0006402)	4.96130837
23	* ribonucleoprotein complex biogenesis (GO:0022613)	4.95631229
24	* RNA catabolic process (GO:0006401)	4.64377862
25	* rRNA processing (GO:0006364)	4.14642259
26	* rRNA metabolic process (GO:0016072)	4.02804120
27	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.90085525
28	* cellular component biogenesis (GO:0044085)	3.74129494
29	ncRNA 3-end processing (GO:0043628)	3.67098048
30	telomere maintenance via semi-conservative replication (GO:0032201)	3.46896002
31	DNA strand elongation involved in DNA replication (GO:0006271)	3.43994262
32	* establishment of protein localization to membrane (GO:0090150)	3.43629979
33	formation of translation preinitiation complex (GO:0001731)	3.43554589
34	spliceosomal snRNP assembly (GO:0000387)	3.41760380
35	chromatin remodeling at centromere (GO:0031055)	3.40775647
36	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.38330421
37	spliceosomal complex assembly (GO:0000245)	3.27662828
38	* establishment of protein localization to organelle (GO:0072594)	3.27279957
39	CENP-A containing nucleosome assembly (GO:0034080)	3.26110459
40	DNA strand elongation (GO:0022616)	3.24338393
41	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.22777267
42	* protein targeting (GO:0006605)	3.21059996
43	establishment of integrated proviral latency (GO:0075713)	3.19208912
44	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.19160259
45	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.19160259
46	purine nucleobase biosynthetic process (GO:0009113)	3.16486740
47	DNA replication checkpoint (GO:0000076)	3.15825753
48	DNA ligation (GO:0006266)	3.13412573
49	kinetochore organization (GO:0051383)	3.13094479
50	chaperone-mediated protein transport (GO:0072321)	3.12753741
51	telomere maintenance via recombination (GO:0000722)	3.08777325
52	pseudouridine synthesis (GO:0001522)	3.08621083
53	DNA deamination (GO:0045006)	3.07370578
54	mitotic metaphase plate congression (GO:0007080)	3.06049571
55	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.04631960
56	termination of RNA polymerase III transcription (GO:0006386)	3.04631960
57	DNA replication initiation (GO:0006270)	3.03368146
58	telomere maintenance via telomere lengthening (GO:0010833)	3.01691082
59	mitotic recombination (GO:0006312)	3.00918777
60	IMP biosynthetic process (GO:0006188)	2.99161947
61	oxidative phosphorylation (GO:0006119)	2.97895198
62	nucleobase biosynthetic process (GO:0046112)	2.96533874
63	GTP biosynthetic process (GO:0006183)	2.95185427
64	UTP biosynthetic process (GO:0006228)	2.92864589
65	DNA unwinding involved in DNA replication (GO:0006268)	2.91908021
66	* ncRNA processing (GO:0034470)	2.89732600
67	kinetochore assembly (GO:0051382)	2.87933310
68	DNA replication-dependent nucleosome assembly (GO:0006335)	2.85497826
69	DNA replication-dependent nucleosome organization (GO:0034723)	2.85497826
70	ribosome biogenesis (GO:0042254)	2.85102736
71	intra-S DNA damage checkpoint (GO:0031573)	2.85050029
72	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.85036837
73	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.85036837
74	NADH dehydrogenase complex assembly (GO:0010257)	2.85036837
75	telomere maintenance via telomerase (GO:0007004)	2.82398773
76	regulation of helicase activity (GO:0051095)	2.82107532
77	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.80515220
78	metaphase plate congression (GO:0051310)	2.77894570
79	DNA topological change (GO:0006265)	2.75045550
80	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.72783951
81	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.72783951
82	proteasome assembly (GO:0043248)	2.71468823
83	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.70680872
84	DNA replication-independent nucleosome assembly (GO:0006336)	2.69714942
85	DNA replication-independent nucleosome organization (GO:0034724)	2.69714942
86	mitochondrial respiratory chain complex assembly (GO:0033108)	2.68198039
87	folic acid-containing compound biosynthetic process (GO:0009396)	2.67663604
88	histone mRNA metabolic process (GO:0008334)	2.67547176
89	protein complex biogenesis (GO:0070271)	2.66569636
90	* ncRNA metabolic process (GO:0034660)	2.65632499
91	cullin deneddylation (GO:0010388)	2.65063379
92	* cellular component disassembly (GO:0022411)	2.64225800
93	protein neddylation (GO:0045116)	2.64172098
94	non-recombinational repair (GO:0000726)	2.61936128
95	double-strand break repair via nonhomologous end joining (GO:0006303)	2.61936128
96	replication fork processing (GO:0031297)	2.60927761
97	* protein localization to membrane (GO:0072657)	2.60218224
98	histone exchange (GO:0043486)	2.59936750
99	mismatch repair (GO:0006298)	2.58685037
100	DNA damage response, detection of DNA damage (GO:0042769)	2.57733519
101	* gene expression (GO:0010467)	2.57504047
102	synapsis (GO:0007129)	2.56483798
103	negative regulation of RNA splicing (GO:0033119)	2.56287748
104	rRNA modification (GO:0000154)	2.55154867
105	DNA catabolic process, exonucleolytic (GO:0000738)	2.55056033
106	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.53321232
107	regulation of mitochondrial translation (GO:0070129)	2.53093424
108	transcription-coupled nucleotide-excision repair (GO:0006283)	2.52550202
109	IMP metabolic process (GO:0046040)	2.51625641
110	UTP metabolic process (GO:0046051)	2.51309532
111	positive regulation of histone H3-K4 methylation (GO:0051571)	2.50932873
112	ribonucleoprotein complex assembly (GO:0022618)	2.49080729
113	* protein localization to organelle (GO:0033365)	2.48508413
114	protein localization to chromosome, centromeric region (GO:0071459)	2.48338599
115	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.48200721
116	interferon-gamma secretion (GO:0072643)	2.47582927
117	regulation of chemokine secretion (GO:0090196)	2.45575617
118	RNA splicing, via transesterification reactions (GO:0000375)	2.44926847
119	DNA-templated transcription, termination (GO:0006353)	2.44028992
120	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.43560455
121	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)	2.42904863
122	mRNA splicing, via spliceosome (GO:0000398)	2.42904863
123	RNA-dependent DNA replication (GO:0006278)	2.42349129
124	negative regulation of translational initiation (GO:0045947)	2.42036777
125	termination of RNA polymerase II transcription (GO:0006369)	2.42002539
126	termination of RNA polymerase I transcription (GO:0006363)	2.41006487
127	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.40119018
128	protein localization to kinetochore (GO:0034501)	2.39780996
129	ATP synthesis coupled proton transport (GO:0015986)	2.39594971
130	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.39594971
131	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.39068093
132	ribonucleoprotein complex subunit organization (GO:0071826)	2.38090481
133	ribosome assembly (GO:0042255)	2.35973101
134	viral mRNA export from host cell nucleus (GO:0046784)	2.33968414

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	7.03454322
2	* MYC_18555785_ChIP-Seq_MESCs_Mouse	5.22202749
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.98196069
4	* MYC_19079543_ChIP-ChIP_MESCs_Mouse	3.84219159
5	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.61455044
6	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.49752492
7	TP63_17297297_ChIP-ChIP_HaCaT_Human	3.34314007
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.33798699
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.32554871
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.24231108
11	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.21705085
12	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.20975748
13	* ETS1_20019798_ChIP-Seq_JURKAT_Human	3.05807681
14	* MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.94059738
15	* CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.93916365
16	* MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.90237244
17	* XRN2_22483619_ChIP-Seq_HELA_Human	2.81885604
18	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.71200434
19	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.65124743
20	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.59510032
21	* TTF2_22483619_ChIP-Seq_HELA_Human	2.50787746
22	* VDR_23849224_ChIP-Seq_CD4+_Human	2.43401214
23	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.41471264
24	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.41174051
25	DCP1A_22483619_ChIP-Seq_HELA_Human	2.35755505
26	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.28756822
27	FOXP3_21729870_ChIP-Seq_TREG_Human	2.23232851
28	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.20760304
29	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.11071296
30	ELK1_19687146_ChIP-ChIP_HELA_Human	2.04425715
31	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.00958727
32	FUS_26573619_Chip-Seq_HEK293_Human	1.99073783
33	EWS_26573619_Chip-Seq_HEK293_Human	1.93616457
34	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.88681469
35	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.83766609
36	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.81552512
37	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.81198703
38	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.76820423
39	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.76734373
40	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.76097439
41	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.75633478
42	* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.64176486
43	* KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.61920816
44	AR_21909140_ChIP-Seq_LNCAP_Human	1.60609991
45	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.60123722
46	MYC_18940864_ChIP-ChIP_HL60_Human	1.57285226
47	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.57246208
48	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.54598972
49	IGF1R_20145208_ChIP-Seq_DFB_Human	1.54595045
50	GABP_19822575_ChIP-Seq_HepG2_Human	1.52314054
51	ZNF274_21170338_ChIP-Seq_K562_Hela	1.51378451
52	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.50841830
53	VDR_22108803_ChIP-Seq_LS180_Human	1.49201434
54	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.46099422
55	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.42668605
56	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.42379337
57	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.39851688
58	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.38824297
59	* POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.35222206
60	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.34918940
61	* ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.34509141
62	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.34089166
63	KDM5A_27292631_Chip-Seq_BREAST_Human	1.32525308
64	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.32433569
65	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.27725220
66	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.26723162
67	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.25074004
68	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.25023286
69	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.24163438
70	* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.23696169
71	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.22205222
72	* FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.22089547
73	* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.19002290
74	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.18227576
75	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.17307868
76	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.15279926
77	IRF1_19129219_ChIP-ChIP_H3396_Human	1.14776793
78	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.14641641
79	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.14641641
80	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.14641641
81	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.13075098
82	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.11225330
83	* ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.10252208
84	* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.08591025
85	* SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.07942000
86	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.07560358
87	CIITA_25753668_ChIP-Seq_RAJI_Human	1.03867101
88	* SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.02993601
89	* KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.02742785
90	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.01007445
91	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.00457124
92	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.99538475
93	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.98281225
94	* KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.96111029
95	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.95884062
96	TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.95127583
97	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.94369283
98	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	0.93765319
99	* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.92934370
100	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.92385294
101	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.92193276
102	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.91778120
103	MYC_22102868_ChIP-Seq_BL_Human	0.91568057
104	* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.89968710
105	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.85873670
106	* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.85414957
107	SPI1_23547873_ChIP-Seq_NB4_Human	0.84683851
108	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.84140445
109	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.82746439
110	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.82076338
111	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.82038135
112	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.80980088
113	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.80086819
114	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.79347646
115	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.78416955
116	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.78241563
117	STAT6_21828071_ChIP-Seq_BEAS2B_Human	0.77892604
118	TAF15_26573619_Chip-Seq_HEK293_Human	0.77331060
119	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.76694894
120	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.76613130
121	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.76315481
122	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.75901942
123	RNF2_27304074_Chip-Seq_NSC_Mouse	0.75298307
124	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.74338120
125	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.73815358
126	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.72606555
127	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.71639470
128	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.71427186

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.92379011
2	MP0003693_abnormal_embryo_hatching	3.71571009
3	MP0004957_abnormal_blastocyst_morpholog	3.44936685
4	MP0010094_abnormal_chromosome_stability	2.98832785
5	MP0003111_abnormal_nucleus_morphology	2.70511563
6	MP0004381_abnormal_hair_follicle	2.68051159
7	MP0003077_abnormal_cell_cycle	2.48340179
8	MP0008932_abnormal_embryonic_tissue	2.43893068
9	MP0002938_white_spotting	2.40759738
10	MP0003941_abnormal_skin_development	2.36879947
11	MP0003136_yellow_coat_color	2.24295157
12	MP0008058_abnormal_DNA_repair	2.20596646
13	MP0009697_abnormal_copulation	2.17187918
14	MP0010030_abnormal_orbit_morphology	2.04635069
15	MP0008007_abnormal_cellular_replicative	1.98660974
16	MP0008995_early_reproductive_senescence	1.84990616
17	MP0006072_abnormal_retinal_apoptosis	1.83576687
18	MP0003123_paternal_imprinting	1.82782331
19	MP0002277_abnormal_respiratory_mucosa	1.79745750
20	MP0008057_abnormal_DNA_replication	1.78791355
21	MP0002163_abnormal_gland_morphology	1.77598473
22	MP0003763_abnormal_thymus_physiology	1.77446860
23	MP0000490_abnormal_crypts_of	1.77339519
24	MP0002102_abnormal_ear_morphology	1.76328364
25	MP0002132_abnormal_respiratory_system	1.76242819
26	MP0003786_premature_aging	1.69724399
27	MP0001529_abnormal_vocalization	1.68236132
28	MP0003315_abnormal_perineum_morphology	1.63174855
29	MP0008004_abnormal_stomach_pH	1.61455762
30	MP0004147_increased_porphyrin_level	1.50083878
31	MP0005084_abnormal_gallbladder_morpholo	1.48546044
32	MP0003121_genomic_imprinting	1.47435165
33	MP0002396_abnormal_hematopoietic_system	1.47025366
34	MP0002796_impaired_skin_barrier	1.46239865
35	MP0002160_abnormal_reproductive_system	1.44213554
36	MP0003787_abnormal_imprinting	1.43996401
37	MP0002009_preneoplasia	1.43490338
38	MP0003890_abnormal_embryonic-extraembry	1.41553754
39	MP0000350_abnormal_cell_proliferation	1.37176025
40	MP0000372_irregular_coat_pigmentation	1.37167393
41	MP0000631_abnormal_neuroendocrine_gland	1.36938351
42	MP0005174_abnormal_tail_pigmentation	1.36536531
43	MP0002234_abnormal_pharynx_morphology	1.32026050
44	MP0005501_abnormal_skin_physiology	1.31840954
45	MP0000566_synostosis	1.29039353
46	MP0000613_abnormal_salivary_gland	1.28650352
47	MP0003186_abnormal_redox_activity	1.24293893
48	MP0009333_abnormal_splenocyte_physiolog	1.22087112
49	MP0003453_abnormal_keratinocyte_physiol	1.21118046
50	MP0005499_abnormal_olfactory_system	1.21007361
51	MP0005394_taste/olfaction_phenotype	1.21007361
52	MP0003122_maternal_imprinting	1.20738297
53	MP0001730_embryonic_growth_arrest	1.18775077
54	MP0002233_abnormal_nose_morphology	1.18056719
55	MP0003718_maternal_effect	1.16998613
56	MP0003011_delayed_dark_adaptation	1.16825189
57	MP0001929_abnormal_gametogenesis	1.16345541
58	MP0003300_gastrointestinal_ulcer	1.15904455
59	MP0009053_abnormal_anal_canal	1.14517539
60	MP0002098_abnormal_vibrissa_morphology	1.14127639
61	MP0000703_abnormal_thymus_morphology	1.13301265
62	MP0001216_abnormal_epidermal_layer	1.12840759
63	MP0000653_abnormal_sex_gland	1.12547488
64	MP0001346_abnormal_lacrimal_gland	1.11381376
65	MP0000858_altered_metastatic_potential	1.10528303
66	MP0001188_hyperpigmentation	1.08869367
67	MP0000049_abnormal_middle_ear	1.07712094
68	MP0008877_abnormal_DNA_methylation	1.05786442
69	MP0002095_abnormal_skin_pigmentation	1.04975205
70	MP0001697_abnormal_embryo_size	1.03334356
71	MP0000762_abnormal_tongue_morphology	1.02030675
72	MP0006035_abnormal_mitochondrial_morpho	1.01292761
73	MP0010352_gastrointestinal_tract_polyps	1.01139508
74	MP0002006_tumorigenesis	1.00482394
75	MP0003938_abnormal_ear_development	1.00433169
76	MP0002166_altered_tumor_susceptibility	1.00025872
77	MP0002060_abnormal_skin_morphology	0.99842346
78	MP0006292_abnormal_olfactory_placode	0.98761207
79	MP0003567_abnormal_fetal_cardiomyocyte	0.98630816
80	MP0002085_abnormal_embryonic_tissue	0.98064745
81	MP0002019_abnormal_tumor_incidence	0.97662567
82	MP0002697_abnormal_eye_size	0.97140979
83	MP0001764_abnormal_homeostasis	0.93021726
84	MP0004142_abnormal_muscle_tone	0.91968687
85	MP0000313_abnormal_cell_death	0.91755553
86	MP0001672_abnormal_embryogenesis/_devel	0.91100163
87	MP0005380_embryogenesis_phenotype	0.91100163
88	MP0005253_abnormal_eye_physiology	0.90265148
89	MP0005367_renal/urinary_system_phenotyp	0.90262522
90	MP0000516_abnormal_urinary_system	0.90262522
91	MP0005391_vision/eye_phenotype	0.89955437
92	MP0004133_heterotaxia	0.89950926
93	MP0005379_endocrine/exocrine_gland_phen	0.89812700
94	MP0005389_reproductive_system_phenotype	0.89807545
95	MP0005076_abnormal_cell_differentiation	0.88705843
96	MP0001286_abnormal_eye_development	0.88641882
97	MP0008789_abnormal_olfactory_epithelium	0.88367252
98	MP0010155_abnormal_intestine_physiology	0.88319424
99	MP0001919_abnormal_reproductive_system	0.88132737
100	MP0001119_abnormal_female_reproductive	0.87559303
101	MP0005645_abnormal_hypothalamus_physiol	0.87419915
102	MP0003806_abnormal_nucleotide_metabolis	0.87143730
103	MP0006276_abnormal_autonomic_nervous	0.86776261
104	MP0005409_darkened_coat_color	0.86554209
105	MP0002080_prenatal_lethality	0.86162646
106	MP0000377_abnormal_hair_follicle	0.84825044
107	MP0006036_abnormal_mitochondrial_physio	0.84511717
108	MP0003698_abnormal_male_reproductive	0.84261974
109	MP0002210_abnormal_sex_determination	0.83572636
110	MP0001293_anophthalmia	0.82655500
111	MP0003724_increased_susceptibility_to	0.82230198
112	MP0004197_abnormal_fetal_growth/weight/	0.80975674
113	MP0002084_abnormal_developmental_patter	0.80924674
114	MP0010771_integument_phenotype	0.78389126
115	MP0003385_abnormal_body_wall	0.78266268
116	MP0002249_abnormal_larynx_morphology	0.77701501
117	MP0000432_abnormal_head_morphology	0.76939432
118	MP0000383_abnormal_hair_follicle	0.76785720
119	MP0002088_abnormal_embryonic_growth/wei	0.76619290
120	MP0009250_abnormal_appendicular_skeleto	0.76236953
121	MP0002111_abnormal_tail_morphology	0.75610464
122	MP0003283_abnormal_digestive_organ	0.75121479
123	MP0001800_abnormal_humoral_immune	0.74895326
124	MP0003984_embryonic_growth_retardation	0.74695909
125	MP0002177_abnormal_outer_ear	0.74481762
126	MP0002722_abnormal_immune_system	0.74350296
127	MP0004808_abnormal_hematopoietic_stem	0.74205840
128	MP0003943_abnormal_hepatobiliary_system	0.74000460
129	MP0002398_abnormal_bone_marrow	0.73419277
130	MP0001340_abnormal_eyelid_morphology	0.73245922
131	MP0003119_abnormal_digestive_system	0.73184535
132	MP0000467_abnormal_esophagus_morphology	0.72651284
133	MP0005075_abnormal_melanosome_morpholog	0.72578782
134	MP0002751_abnormal_autonomic_nervous	0.72574219
135	MP0000358_abnormal_cell_content/	0.72039034
136	MP0003755_abnormal_palate_morphology	0.71537411
137	MP0002138_abnormal_hepatobiliary_system	0.71479815
138	MP0005220_abnormal_exocrine_pancreas	0.71343734
139	MP0002837_dystrophic_cardiac_calcinosis	0.71088431
140	MP0002653_abnormal_ependyma_morphology	0.69035589
141	MP0003448_altered_tumor_morphology	0.68737230
142	MP0002092_abnormal_eye_morphology	0.68677419
143	MP0003937_abnormal_limbs/digits/tail_de	0.67838081
144	MP0000537_abnormal_urethra_morphology	0.67813571
145	MP0002086_abnormal_extraembryonic_tissu	0.67674156
146	MP0000477_abnormal_intestine_morphology	0.67358228
147	MP0003861_abnormal_nervous_system	0.67331223
148	MP0001145_abnormal_male_reproductive	0.66401582
149	MP0005023_abnormal_wound_healing	0.66227159
150	MP0001348_abnormal_lacrimal_gland	0.65393215

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	8.03972065
2	Abnormality of cells of the erythroid lineage (HP:0012130)	7.21714334
3	Abnormal number of erythroid precursors (HP:0012131)	6.24422875
4	* Macrocytic anemia (HP:0001972)	5.77232189
5	* Pallor (HP:0000980)	5.01816651
6	Aplasia/Hypoplasia of the sacrum (HP:0008517)	4.50371731
7	Colon cancer (HP:0003003)	3.36633792
8	Trismus (HP:0000211)	3.25580629
9	Increased hepatocellular lipid droplets (HP:0006565)	3.19945252
10	Absent thumb (HP:0009777)	3.19042957
11	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.11625133
12	Microvesicular hepatic steatosis (HP:0001414)	2.94024162
13	* Abnormal hemoglobin (HP:0011902)	2.85483300
14	Oral leukoplakia (HP:0002745)	2.81543551
15	Acute encephalopathy (HP:0006846)	2.74784302
16	Abnormality of the preputium (HP:0100587)	2.71166053
17	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.70358044
18	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.70358044
19	11 pairs of ribs (HP:0000878)	2.65104436
20	Stenosis of the external auditory canal (HP:0000402)	2.64948818
21	Abnormality of the labia minora (HP:0012880)	2.64713156
22	* Depressed nasal ridge (HP:0000457)	2.62692816
23	Congenital, generalized hypertrichosis (HP:0004540)	2.59533831
24	Lipid accumulation in hepatocytes (HP:0006561)	2.59475049
25	Mitochondrial inheritance (HP:0001427)	2.59426765
26	Cleft eyelid (HP:0000625)	2.57695601
27	Concave nail (HP:0001598)	2.52536981
28	Rough bone trabeculation (HP:0100670)	2.50744859
29	Exertional dyspnea (HP:0002875)	2.45785581
30	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.45519388
31	Ridged nail (HP:0001807)	2.44166116
32	Hepatocellular necrosis (HP:0001404)	2.40927236
33	Hypoplasia of the radius (HP:0002984)	2.38796949
34	* Triphalangeal thumb (HP:0001199)	2.37947646
35	Chromsome breakage (HP:0040012)	2.36389897
36	3-Methylglutaconic aciduria (HP:0003535)	2.29902801
37	Molar tooth sign on MRI (HP:0002419)	2.29682169
38	Abnormality of midbrain morphology (HP:0002418)	2.29682169
39	Volvulus (HP:0002580)	2.28618525
40	Horseshoe kidney (HP:0000085)	2.26631237
41	Thrombocytosis (HP:0001894)	2.23915329
42	Cerebral edema (HP:0002181)	2.22401970
43	Rhabdomyosarcoma (HP:0002859)	2.19914168
44	Breast hypoplasia (HP:0003187)	2.19544506
45	Septo-optic dysplasia (HP:0100842)	2.19134934
46	Abnormality of reticulocytes (HP:0004312)	2.18442180
47	Increased CSF lactate (HP:0002490)	2.17371150
48	Hyperglycinemia (HP:0002154)	2.17149417
49	Fragile nails (HP:0001808)	2.16222744
50	Abnormality of DNA repair (HP:0003254)	2.14704982
51	Pancreatic cysts (HP:0001737)	2.14137415
52	Rectal prolapse (HP:0002035)	2.13816036
53	True hermaphroditism (HP:0010459)	2.13305412
54	Renal Fanconi syndrome (HP:0001994)	2.13194488
55	Acute necrotizing encephalopathy (HP:0006965)	2.13047247
56	Aplastic anemia (HP:0001915)	2.12847242
57	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.12340549
58	Abnormality of chromosome stability (HP:0003220)	2.11428212
59	Pancreatic fibrosis (HP:0100732)	2.11176362
60	Woolly hair (HP:0002224)	2.10572699
61	Amniotic constriction ring (HP:0009775)	2.10054242
62	Abnormality of placental membranes (HP:0011409)	2.10054242
63	Sparse eyelashes (HP:0000653)	2.09956361
64	Sparse lateral eyebrow (HP:0005338)	2.09691369
65	Secondary amenorrhea (HP:0000869)	2.09464727
66	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	2.05257891
67	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.04819328
68	Respiratory difficulties (HP:0002880)	2.04344893
69	Short middle phalanx of the 5th finger (HP:0004220)	2.03247557
70	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.02422791
71	* Thick lower lip vermilion (HP:0000179)	2.01246054
72	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.00983296
73	Increased serum lactate (HP:0002151)	2.00829248
74	Meckel diverticulum (HP:0002245)	1.97067827
75	Atresia of the external auditory canal (HP:0000413)	1.95862013
76	Neoplasm of the pancreas (HP:0002894)	1.94779563
77	Nephronophthisis (HP:0000090)	1.94158724
78	Lactic acidosis (HP:0003128)	1.94131825
79	Sparse scalp hair (HP:0002209)	1.93896784
80	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	1.92893028
81	Congenital sensorineural hearing impairment (HP:0008527)	1.92875140
82	Abnormal trabecular bone morphology (HP:0100671)	1.92735126
83	Premature graying of hair (HP:0002216)	1.92522148
84	Methylmalonic acidemia (HP:0002912)	1.92511571
85	Biliary tract neoplasm (HP:0100574)	1.89836540
86	Glossoptosis (HP:0000162)	1.87477316
87	Absent radius (HP:0003974)	1.86211652
88	Progressive macrocephaly (HP:0004481)	1.86040228
89	Birth length less than 3rd percentile (HP:0003561)	1.85686256
90	Abnormality of alanine metabolism (HP:0010916)	1.84788990
91	Hyperalaninemia (HP:0003348)	1.84788990
92	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.84788990
93	Sloping forehead (HP:0000340)	1.84712444
94	Abnormal mitochondria in muscle tissue (HP:0008316)	1.83558128
95	Increased intramyocellular lipid droplets (HP:0012240)	1.81788477
96	Abnormality of the ileum (HP:0001549)	1.81711096
97	Optic disc pallor (HP:0000543)	1.80921722
98	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.80526811
99	Abnormality of serum amino acid levels (HP:0003112)	1.79649313
100	Optic nerve coloboma (HP:0000588)	1.79284554
101	Poikiloderma (HP:0001029)	1.79089539
102	Cheilitis (HP:0100825)	1.78987133
103	Premature ovarian failure (HP:0008209)	1.78858876
104	Medial flaring of the eyebrow (HP:0010747)	1.78359667
105	Basal cell carcinoma (HP:0002671)	1.78271379
106	Hepatic necrosis (HP:0002605)	1.78030906
107	Down-sloping shoulders (HP:0200021)	1.77907427
108	Small intestinal stenosis (HP:0012848)	1.77769902
109	Duodenal stenosis (HP:0100867)	1.77769902
110	Acute lymphatic leukemia (HP:0006721)	1.76382292
111	Supernumerary spleens (HP:0009799)	1.74982616
112	Neoplasm of the colon (HP:0100273)	1.74356544
113	Pulmonary fibrosis (HP:0002206)	1.73395917
114	Medulloblastoma (HP:0002885)	1.72273456
115	Type I transferrin isoform profile (HP:0003642)	1.71229082
116	Absent forearm bone (HP:0003953)	1.70999217
117	Aplasia involving forearm bones (HP:0009822)	1.70999217
118	Abnormal lung lobation (HP:0002101)	1.70598492
119	Asplenia (HP:0001746)	1.70326999
120	Aplasia/hypoplasia of the uterus (HP:0008684)	1.70308429
121	Pancytopenia (HP:0001876)	1.69634724
122	Increased serum pyruvate (HP:0003542)	1.69604228
123	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.69472143
124	Abnormality of the duodenum (HP:0002246)	1.68481625
125	Missing ribs (HP:0000921)	1.67951384
126	Cerebral hypomyelination (HP:0006808)	1.67303254
127	Chronic hepatic failure (HP:0100626)	1.67001966
128	Intestinal atresia (HP:0011100)	1.66466435
129	Nephroblastoma (Wilms tumor) (HP:0002667)	1.66100439
130	T lymphocytopenia (HP:0005403)	1.66090079
131	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.64981975
132	Exercise intolerance (HP:0003546)	1.64934199
133	* Migraine (HP:0002076)	1.64439228
134	Facial cleft (HP:0002006)	1.63963604
135	Ectopic kidney (HP:0000086)	1.63403936
136	Aplasia/Hypoplasia of the thymus (HP:0010515)	1.63327062
137	Progressive external ophthalmoplegia (HP:0000590)	1.62917820
138	Aplasia/Hypoplasia of the patella (HP:0006498)	1.62089085
139	Patellar aplasia (HP:0006443)	1.61126281
140	Multiple enchondromatosis (HP:0005701)	1.60861171
141	Sclerocornea (HP:0000647)	1.59985239
142	Testicular atrophy (HP:0000029)	1.59643033
143	Abnormality of methionine metabolism (HP:0010901)	1.59054633
144	Lip pit (HP:0100267)	1.58778328
145	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.58776052
146	Increased muscle lipid content (HP:0009058)	1.58494162
147	Bilateral microphthalmos (HP:0007633)	1.58347606
148	Myelodysplasia (HP:0002863)	1.58200476
149	Abnormal rod and cone electroretinograms (HP:0008323)	1.57483059
150	Embryonal renal neoplasm (HP:0011794)	1.57352619
151	Abnormality of the renal collecting system (HP:0004742)	1.55807408

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	6.78687957
2	NME2	4.44658087
3	EIF2AK1	4.33333778
4	BUB1	3.15756398
5	VRK2	3.00075333
6	SRPK1	2.63942168
7	WEE1	2.52992876
8	PBK	2.52724043
9	MKNK2	2.26802517
10	MST4	2.22544928
11	MAP4K2	2.20507136
12	VRK1	2.16229684
13	TAF1	2.12307455
14	CDC7	2.07469435
15	TRIM28	1.95937880
16	MKNK1	1.88811590
17	RPS6KB2	1.80328726
18	NEK1	1.79261714
19	RPS6KA4	1.62665201
20	IRAK3	1.62118690
21	NME1	1.59196425
22	NEK2	1.49233879
23	AURKB	1.48397746
24	EIF2AK3	1.47344298
25	TESK2	1.44305000
26	PLK1	1.39832231
27	TSSK6	1.39005859
28	NLK	1.37594720
29	NEK9	1.36774871
30	TTK	1.29785079
31	BCKDK	1.28025217
32	ZAK	1.25732841
33	CDK7	1.25488690
34	TNIK	1.24903642
35	WNK3	1.22239196
36	STK16	1.22074295
37	SCYL2	1.17600928
38	PASK	1.17574869
39	DYRK3	1.13436931
40	AURKA	1.11310467
41	LMTK2	1.09879895
42	BRSK2	1.07775468
43	EIF2AK2	1.07608726
44	PNCK	1.05939974
45	RPS6KA5	1.04968366
46	IRAK4	1.03931697
47	PLK4	0.97331755
48	MAP3K11	0.95354826
49	MAP3K4	0.90896446
50	STK10	0.90624956
51	CDK4	0.89168306
52	BLK	0.89167666
53	CDK19	0.88967486
54	EPHA2	0.87684656
55	MAP4K1	0.84875909
56	CDK3	0.83708549
57	PIM2	0.83095650
58	CDK8	0.81245301
59	CHEK2	0.80525290
60	ACVR1B	0.79685918
61	ATR	0.77847165
62	TEC	0.77657182
63	IRAK1	0.77293691
64	CSNK2A2	0.77100376
65	STK3	0.75097441
66	TXK	0.74764272
67	CDK9	0.74609287
68	CDK12	0.72884797
69	STK39	0.72124396
70	PRKD2	0.71718504
71	STK4	0.71470548
72	PIM1	0.71428998
73	MAP3K8	0.71308650
74	LRRK2	0.70238054
75	CSNK2A1	0.67546039
76	WNK4	0.66884723
77	BRD4	0.66644016
78	TGFBR1	0.66170164
79	NUAK1	0.65889382
80	GRK1	0.65773390
81	IKBKB	0.65299544
82	CDK6	0.64999627
83	CSNK1G1	0.64883930
84	STK38L	0.64672509
85	CLK1	0.64377980
86	PDK2	0.63267099
87	LATS1	0.62680191
88	INSRR	0.62349555
89	KIT	0.61012753
90	BRSK1	0.59534624
91	MAPKAPK5	0.58391110
92	CHEK1	0.57127859
93	ATM	0.56785472
94	ERBB3	0.56603510
95	YES1	0.55465119
96	PLK3	0.55382041
97	CSNK1G3	0.53865104
98	MST1R	0.53261159
99	IRAK2	0.52692120
100	CSNK1E	0.52690230
101	IKBKE	0.52131656
102	ZAP70	0.50767033
103	EEF2K	0.49577262
104	ILK	0.49509578
105	CASK	0.49203942
106	CSNK1G2	0.48146452
107	PAK1	0.47936462
108	MAP3K10	0.47050381
109	CDK2	0.46113532
110	DAPK1	0.46107874
111	EPHB2	0.44175533
112	ALK	0.44059574
113	MAPKAPK3	0.43966091
114	RPS6KA6	0.42122639
115	CCNB1	0.41740607
116	BMPR1B	0.40650000
117	TIE1	0.40058174
118	MAP2K2	0.39537343
119	RPS6KC1	0.38458467
120	RPS6KL1	0.38458467
121	MELK	0.38026010
122	PRKDC	0.37177817
123	STK38	0.37175556
124	MAP3K12	0.36509435
125	TAOK3	0.34937339
126	PRKCI	0.33962344
127	LCK	0.33311468
128	DAPK3	0.33278375
129	FGFR1	0.30672808
130	BCR	0.30596912
131	RPS6KB1	0.29973159
132	FLT3	0.29935077
133	TESK1	0.29680165
134	GRK6	0.28534299
135	PRKG2	0.28141579
136	CSNK1A1L	0.27927139
137	MAP3K3	0.27326061
138	DYRK2	0.25907495
139	MAP2K6	0.25806353
140	CDK1	0.25664300

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	* Ribosome_Homo sapiens_hsa03010	7.70707693
2	DNA replication_Homo sapiens_hsa03030	3.69255088
3	Mismatch repair_Homo sapiens_hsa03430	3.22288603
4	RNA polymerase_Homo sapiens_hsa03020	3.11749563
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.07353345
6	Spliceosome_Homo sapiens_hsa03040	3.03591453
7	Homologous recombination_Homo sapiens_hsa03440	3.03098203
8	Proteasome_Homo sapiens_hsa03050	2.47792321
9	RNA transport_Homo sapiens_hsa03013	2.30571089
10	One carbon pool by folate_Homo sapiens_hsa00670	2.29073878
11	Nucleotide excision repair_Homo sapiens_hsa03420	2.28561004
12	Fanconi anemia pathway_Homo sapiens_hsa03460	2.08219356
13	Pyrimidine metabolism_Homo sapiens_hsa00240	2.07906581
14	Base excision repair_Homo sapiens_hsa03410	2.02139734
15	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.88375078
16	Protein export_Homo sapiens_hsa03060	1.81878662
17	Cell cycle_Homo sapiens_hsa04110	1.69989585
18	Oxidative phosphorylation_Homo sapiens_hsa00190	1.69590005
19	Basal transcription factors_Homo sapiens_hsa03022	1.68208907
20	Parkinsons disease_Homo sapiens_hsa05012	1.65672986
21	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.60819813
22	Non-homologous end-joining_Homo sapiens_hsa03450	1.59346403
23	Propanoate metabolism_Homo sapiens_hsa00640	1.58988045
24	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.53475190
25	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.51470182
26	Huntingtons disease_Homo sapiens_hsa05016	1.48574946
27	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.43204721
28	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.42009382
29	RNA degradation_Homo sapiens_hsa03018	1.38903540
30	mRNA surveillance pathway_Homo sapiens_hsa03015	1.28750437
31	p53 signaling pathway_Homo sapiens_hsa04115	1.22487850
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.22074291
33	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.21834753
34	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.16329781
35	Fatty acid elongation_Homo sapiens_hsa00062	1.15715136
36	Sulfur relay system_Homo sapiens_hsa04122	1.09505817
37	Pyruvate metabolism_Homo sapiens_hsa00620	1.06593047
38	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.04719753
39	Selenocompound metabolism_Homo sapiens_hsa00450	1.02458970
40	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.02183871
41	Alzheimers disease_Homo sapiens_hsa05010	1.00200670
42	Purine metabolism_Homo sapiens_hsa00230	0.99626405
43	Herpes simplex infection_Homo sapiens_hsa05168	0.95555543
44	Antigen processing and presentation_Homo sapiens_hsa04612	0.93744036
45	Primary immunodeficiency_Homo sapiens_hsa05340	0.87877750
46	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.86256328
47	Butanoate metabolism_Homo sapiens_hsa00650	0.84372427
48	Basal cell carcinoma_Homo sapiens_hsa05217	0.83134791
49	Folate biosynthesis_Homo sapiens_hsa00790	0.82312783
50	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.74854284
51	Thyroid cancer_Homo sapiens_hsa05216	0.74240968
52	Alcoholism_Homo sapiens_hsa05034	0.70452464
53	Carbon metabolism_Homo sapiens_hsa01200	0.70327168
54	Viral carcinogenesis_Homo sapiens_hsa05203	0.70166686
55	HTLV-I infection_Homo sapiens_hsa05166	0.70008197
56	Peroxisome_Homo sapiens_hsa04146	0.69094670
57	Regulation of autophagy_Homo sapiens_hsa04140	0.68034120
58	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.66466818
59	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.66030101
60	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.65394833
61	Steroid biosynthesis_Homo sapiens_hsa00100	0.61910324
62	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.61575938
63	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.59391853
64	Phototransduction_Homo sapiens_hsa04744	0.58123898
65	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.57357326
66	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.57068295
67	Measles_Homo sapiens_hsa05162	0.56177179
68	Pentose phosphate pathway_Homo sapiens_hsa00030	0.55574799
69	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.51954602
70	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.51519762
71	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.51436812
72	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.51118583
73	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.49425366
74	MicroRNAs in cancer_Homo sapiens_hsa05206	0.48393323
75	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.48192687
76	Bladder cancer_Homo sapiens_hsa05219	0.47587115
77	Glutathione metabolism_Homo sapiens_hsa00480	0.47039153
78	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.45290612
79	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.44446037
80	Sphingolipid metabolism_Homo sapiens_hsa00600	0.42759523
81	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.42540657
82	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.42534303
83	Small cell lung cancer_Homo sapiens_hsa05222	0.41718029
84	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.40419924
85	Apoptosis_Homo sapiens_hsa04210	0.36096145
86	Nitrogen metabolism_Homo sapiens_hsa00910	0.35988165
87	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.35699482
88	Oocyte meiosis_Homo sapiens_hsa04114	0.35073225
89	Wnt signaling pathway_Homo sapiens_hsa04310	0.34730912
90	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.34008001
91	Legionellosis_Homo sapiens_hsa05134	0.33834737
92	Acute myeloid leukemia_Homo sapiens_hsa05221	0.33540734
93	Hepatitis B_Homo sapiens_hsa05161	0.32824873
94	Prostate cancer_Homo sapiens_hsa05215	0.32359739
95	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.32177514
96	Influenza A_Homo sapiens_hsa05164	0.31901021
97	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.31143394
98	Cardiac muscle contraction_Homo sapiens_hsa04260	0.30810549
99	Graft-versus-host disease_Homo sapiens_hsa05332	0.30738546
100	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.30625100
101	Hippo signaling pathway_Homo sapiens_hsa04390	0.30463855
102	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.29073136
103	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.28998120
104	Ether lipid metabolism_Homo sapiens_hsa00565	0.28960859
105	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.28913969
106	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.28705435
107	Olfactory transduction_Homo sapiens_hsa04740	0.28372080
108	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.27249767
109	Tryptophan metabolism_Homo sapiens_hsa00380	0.27222711
110	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.26438807
111	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.26053561
112	Type I diabetes mellitus_Homo sapiens_hsa04940	0.25485521
113	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.25479582
114	Pathways in cancer_Homo sapiens_hsa05200	0.25455323
115	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.24611461
116	Fatty acid metabolism_Homo sapiens_hsa01212	0.23839879
117	Other glycan degradation_Homo sapiens_hsa00511	0.22074913
118	Colorectal cancer_Homo sapiens_hsa05210	0.21592167
119	Notch signaling pathway_Homo sapiens_hsa04330	0.21522809
120	Fat digestion and absorption_Homo sapiens_hsa04975	0.21457721
121	Allograft rejection_Homo sapiens_hsa05330	0.21240665
122	Linoleic acid metabolism_Homo sapiens_hsa00591	0.20946220
123	Metabolic pathways_Homo sapiens_hsa01100	0.20943121
124	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.20489206
125	Melanoma_Homo sapiens_hsa05218	0.19820238
126	Asthma_Homo sapiens_hsa05310	0.19604307
127	Hepatitis C_Homo sapiens_hsa05160	0.19514730
128	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.18284305
129	Fatty acid degradation_Homo sapiens_hsa00071	0.18261762
130	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.16537937
131	Retinol metabolism_Homo sapiens_hsa00830	0.16492043
132	Leishmaniasis_Homo sapiens_hsa05140	0.16323805
133	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.15143707
134	Shigellosis_Homo sapiens_hsa05131	0.15116840
135	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.12990523
136	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.12732513
137	Lysine degradation_Homo sapiens_hsa00310	0.12303015
138	beta-Alanine metabolism_Homo sapiens_hsa00410	0.11989067
139	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.11977696
140	Adherens junction_Homo sapiens_hsa04520	0.11279049
141	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.08176898

RPL5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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