RPL5P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ATP synthesis coupled proton transport (GO:0015986)5.11243569
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.11243569
3DNA deamination (GO:0045006)4.75597118
4ribosomal small subunit assembly (GO:0000028)4.72556296
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.67170370
6protein neddylation (GO:0045116)4.62248645
7maturation of SSU-rRNA (GO:0030490)4.31895104
8water-soluble vitamin biosynthetic process (GO:0042364)4.10256117
9viral transcription (GO:0019083)4.09769255
10chaperone-mediated protein transport (GO:0072321)4.08251348
11protein complex biogenesis (GO:0070271)4.07196197
12establishment of protein localization to mitochondrial membrane (GO:0090151)4.00543425
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.00262943
14translational termination (GO:0006415)3.99859075
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.99220177
16mitochondrial respiratory chain complex I assembly (GO:0032981)3.99220177
17NADH dehydrogenase complex assembly (GO:0010257)3.99220177
18tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.96293817
19RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.96293817
20behavioral response to nicotine (GO:0035095)3.89116281
21nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.81809569
22exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.78228100
23SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.77637979
24cotranslational protein targeting to membrane (GO:0006613)3.71538361
25ribosomal large subunit biogenesis (GO:0042273)3.70511037
26mitochondrial respiratory chain complex assembly (GO:0033108)3.69733416
27protein targeting to ER (GO:0045047)3.68903980
28GTP biosynthetic process (GO:0006183)3.64879875
29positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.64328171
30preassembly of GPI anchor in ER membrane (GO:0016254)3.57537123
31establishment of protein localization to endoplasmic reticulum (GO:0072599)3.56805478
32protein localization to endoplasmic reticulum (GO:0070972)3.51988188
33translational elongation (GO:0006414)3.51171212
34regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.36610840
35electron transport chain (GO:0022900)3.35950419
36GPI anchor metabolic process (GO:0006505)3.32389454
37respiratory electron transport chain (GO:0022904)3.31850649
38somite development (GO:0061053)3.24801137
39mannosylation (GO:0097502)3.23183345
40purine nucleoside triphosphate biosynthetic process (GO:0009145)3.16123205
41L-fucose catabolic process (GO:0042355)3.16083810
42fucose catabolic process (GO:0019317)3.16083810
43L-fucose metabolic process (GO:0042354)3.16083810
44purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.14831613
45GPI anchor biosynthetic process (GO:0006506)3.12338293
46regulation of isotype switching to IgG isotypes (GO:0048302)3.09959049
47negative regulation of mast cell activation (GO:0033004)3.09546038
48kynurenine metabolic process (GO:0070189)3.08158421
49platelet dense granule organization (GO:0060155)3.04959577
50viral life cycle (GO:0019058)2.99990370
51ATP biosynthetic process (GO:0006754)2.99026899
52pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.97378227
53regulation of immunoglobulin secretion (GO:0051023)2.96550257
54translation (GO:0006412)2.96035527
55positive regulation of prostaglandin secretion (GO:0032308)2.95886134
56UTP biosynthetic process (GO:0006228)2.95756801
57respiratory chain complex IV assembly (GO:0008535)2.90803749
58piRNA metabolic process (GO:0034587)2.90737611
59base-excision repair, AP site formation (GO:0006285)2.89743648
60regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.88646503
61cellular protein complex disassembly (GO:0043624)2.88276557
62termination of RNA polymerase III transcription (GO:0006386)2.88051401
63transcription elongation from RNA polymerase III promoter (GO:0006385)2.88051401
64translational initiation (GO:0006413)2.84357160
65UTP metabolic process (GO:0046051)2.83858451
66response to pheromone (GO:0019236)2.80369314
67hydrogen ion transmembrane transport (GO:1902600)2.79837923
68negative regulation of telomere maintenance (GO:0032205)2.79271944
69proteasome assembly (GO:0043248)2.78836687
70tRNA processing (GO:0008033)2.76019338
71epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.74051952
72nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.72601008
73ribosomal small subunit biogenesis (GO:0042274)2.69845019
74cellular component biogenesis (GO:0044085)2.69695410
75proton transport (GO:0015992)2.69641877
76C-terminal protein lipidation (GO:0006501)2.65828414
77ribonucleoside triphosphate biosynthetic process (GO:0009201)2.65373967
78protein deneddylation (GO:0000338)2.64935981
79tryptophan catabolic process (GO:0006569)2.64103339
80indole-containing compound catabolic process (GO:0042436)2.64103339
81indolalkylamine catabolic process (GO:0046218)2.64103339
82hydrogen transport (GO:0006818)2.63879722
83ubiquinone biosynthetic process (GO:0006744)2.61010539
84cytochrome complex assembly (GO:0017004)2.60056262
85endoderm formation (GO:0001706)2.59663032
86cullin deneddylation (GO:0010388)2.59257170
87regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.58348424
88regulation of mitotic spindle checkpoint (GO:1903504)2.58348424
89C-terminal protein amino acid modification (GO:0018410)2.57002104
90ubiquinone metabolic process (GO:0006743)2.56221790
91protein-cofactor linkage (GO:0018065)2.54991786
92auditory receptor cell stereocilium organization (GO:0060088)2.54194248
93parturition (GO:0007567)2.53320861
94positive regulation of fatty acid transport (GO:2000193)2.52381161
95detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.51890416
96peptidyl-histidine modification (GO:0018202)2.51554176
97indolalkylamine metabolic process (GO:0006586)2.47763916
98protein localization to cilium (GO:0061512)2.47166071
99negative regulation of heart rate (GO:0010459)2.43640327
100protein polyglutamylation (GO:0018095)2.42608164

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.67798053
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.38326653
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.14536326
4ZNF274_21170338_ChIP-Seq_K562_Hela3.04229625
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.95518651
6VDR_22108803_ChIP-Seq_LS180_Human2.94589703
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.91061823
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.54524430
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.54005997
10IGF1R_20145208_ChIP-Seq_DFB_Human2.20935476
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12145872
12VDR_23849224_ChIP-Seq_CD4+_Human2.12006010
13EZH2_22144423_ChIP-Seq_EOC_Human2.08914170
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.07606365
15TAF15_26573619_Chip-Seq_HEK293_Human2.05712581
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.04758298
17EWS_26573619_Chip-Seq_HEK293_Human2.03602173
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.95658723
19ETS1_20019798_ChIP-Seq_JURKAT_Human1.91205719
20ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91205403
21MYC_18940864_ChIP-ChIP_HL60_Human1.90396642
22ELK1_19687146_ChIP-ChIP_HELA_Human1.85539396
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.83924848
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80614703
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80569542
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79893861
27PCGF2_27294783_Chip-Seq_NPCs_Mouse1.76527653
28IRF1_19129219_ChIP-ChIP_H3396_Human1.73719783
29P300_19829295_ChIP-Seq_ESCs_Human1.72691728
30GBX2_23144817_ChIP-Seq_PC3_Human1.68714404
31FUS_26573619_Chip-Seq_HEK293_Human1.65438293
32FOXP3_21729870_ChIP-Seq_TREG_Human1.64592746
33TP53_22573176_ChIP-Seq_HFKS_Human1.63847585
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57319736
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52975427
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.48989985
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48465428
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46935567
39MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46174165
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45859622
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44169556
42CBP_20019798_ChIP-Seq_JUKART_Human1.44169556
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.43762749
44ER_23166858_ChIP-Seq_MCF-7_Human1.43209659
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.39216857
46GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.39168670
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37946238
48NANOG_19829295_ChIP-Seq_ESCs_Human1.36349690
49SOX2_19829295_ChIP-Seq_ESCs_Human1.36349690
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36051268
51FOXA1_25329375_ChIP-Seq_VCAP_Human1.36051268
52CREB1_15753290_ChIP-ChIP_HEK293T_Human1.30719091
53CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.27893221
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26666507
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.26353105
56AR_20517297_ChIP-Seq_VCAP_Human1.24076323
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.21189754
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19328615
59RNF2_27304074_Chip-Seq_NSC_Mouse1.19114208
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18662501
61GATA3_21878914_ChIP-Seq_MCF-7_Human1.18651117
62AUTS2_25519132_ChIP-Seq_293T-REX_Human1.18542644
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18321265
64BCAT_22108803_ChIP-Seq_LS180_Human1.17935354
65MYC_19829295_ChIP-Seq_ESCs_Human1.17227440
66NCOR_22424771_ChIP-Seq_293T_Human1.17218565
67ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16222069
68MYC_18555785_ChIP-Seq_MESCs_Mouse1.14880982
69KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11146741
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.10843048
71TCF4_22108803_ChIP-Seq_LS180_Human1.08373156
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07415232
73TTF2_22483619_ChIP-Seq_HELA_Human1.07196909
74NANOG_20526341_ChIP-Seq_ESCs_Human1.05574127
75FOXH1_21741376_ChIP-Seq_EPCs_Human1.04390982
76GATA3_26560356_Chip-Seq_TH2_Human1.04385885
77FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03573046
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01309171
79TAF2_19829295_ChIP-Seq_ESCs_Human1.01127513
80PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01030070
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00095892
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97673785
83PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.97645666
84PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96515962
85BP1_19119308_ChIP-ChIP_Hs578T_Human0.96151544
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96113011
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95624685
88HOXB7_26014856_ChIP-Seq_BT474_Human0.94212326
89CRX_20693478_ChIP-Seq_RETINA_Mouse0.94054343
90TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93342922
91ERG_20517297_ChIP-Seq_VCAP_Human0.91878262
92EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91059367
93ERA_21632823_ChIP-Seq_H3396_Human0.90502556
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88829529
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88551603
96P53_22387025_ChIP-Seq_ESCs_Mouse0.87684941
97CDX2_22108803_ChIP-Seq_LS180_Human0.87447688
98SMAD3_21741376_ChIP-Seq_EPCs_Human0.87027267
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86974115
100YY1_21170310_ChIP-Seq_MESCs_Mouse0.86973797

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.16558690
2MP0009379_abnormal_foot_pigmentation3.23045995
3MP0008877_abnormal_DNA_methylation2.81619878
4MP0002102_abnormal_ear_morphology2.52863720
5MP0005671_abnormal_response_to2.43931440
6MP0002736_abnormal_nociception_after2.21417367
7MP0005646_abnormal_pituitary_gland2.15205808
8MP0003787_abnormal_imprinting2.13303772
9MP0006072_abnormal_retinal_apoptosis2.12272468
10MP0002138_abnormal_hepatobiliary_system2.11420827
11MP0001968_abnormal_touch/_nociception2.03216819
12MP0005645_abnormal_hypothalamus_physiol1.96825441
13MP0004142_abnormal_muscle_tone1.96437700
14MP0004147_increased_porphyrin_level1.93723792
15MP0008875_abnormal_xenobiotic_pharmacok1.93494745
16MP0008872_abnormal_physiological_respon1.91287157
17MP0004885_abnormal_endolymph1.87237390
18MP0001835_abnormal_antigen_presentation1.82385930
19MP0005551_abnormal_eye_electrophysiolog1.73115869
20MP0003880_abnormal_central_pattern1.73092922
21MP0001529_abnormal_vocalization1.72512950
22MP0006276_abnormal_autonomic_nervous1.69027814
23MP0003195_calcinosis1.68294806
24MP0005084_abnormal_gallbladder_morpholo1.63460407
25MP0002837_dystrophic_cardiac_calcinosis1.52436216
26MP0003122_maternal_imprinting1.48097316
27MP0003646_muscle_fatigue1.47479632
28MP0001986_abnormal_taste_sensitivity1.47300100
29MP0002272_abnormal_nervous_system1.44459089
30MP0001293_anophthalmia1.44040671
31MP0002163_abnormal_gland_morphology1.42524360
32MP0003011_delayed_dark_adaptation1.42142666
33MP0002938_white_spotting1.42070249
34MP0002277_abnormal_respiratory_mucosa1.37857974
35MP0002653_abnormal_ependyma_morphology1.34669985
36MP0005389_reproductive_system_phenotype1.32676792
37MP0008058_abnormal_DNA_repair1.30075214
38MP0008789_abnormal_olfactory_epithelium1.27683566
39MP0001188_hyperpigmentation1.23714513
40MP0003718_maternal_effect1.22756425
41MP0003724_increased_susceptibility_to1.22317365
42MP0005253_abnormal_eye_physiology1.22284403
43MP0001905_abnormal_dopamine_level1.20395977
44MP0000372_irregular_coat_pigmentation1.20173652
45MP0003878_abnormal_ear_physiology1.19703483
46MP0005377_hearing/vestibular/ear_phenot1.19703483
47MP0001919_abnormal_reproductive_system1.19586640
48MP0001440_abnormal_grooming_behavior1.17189696
49MP0004145_abnormal_muscle_electrophysio1.17030011
50MP0005075_abnormal_melanosome_morpholog1.16637307
51MP0009745_abnormal_behavioral_response1.16355625
52MP0002160_abnormal_reproductive_system1.15231467
53MP0008775_abnormal_heart_ventricle1.13407611
54MP0000631_abnormal_neuroendocrine_gland1.12068407
55MP0001970_abnormal_pain_threshold1.11575955
56MP0002876_abnormal_thyroid_physiology1.11468323
57MP0002234_abnormal_pharynx_morphology1.09668847
58MP0008995_early_reproductive_senescence1.09154432
59MP0004133_heterotaxia1.08949503
60MP0002735_abnormal_chemical_nociception1.08024303
61MP0002822_catalepsy1.07646934
62MP0001486_abnormal_startle_reflex1.04334416
63MP0003186_abnormal_redox_activity1.03674753
64MP0001485_abnormal_pinna_reflex1.02760878
65MP0003121_genomic_imprinting1.01827244
66MP0005379_endocrine/exocrine_gland_phen0.99336099
67MP0000427_abnormal_hair_cycle0.95776298
68MP0004742_abnormal_vestibular_system0.95716554
69MP0001800_abnormal_humoral_immune0.95668054
70MP0001873_stomach_inflammation0.94109427
71MP0002148_abnormal_hypersensitivity_rea0.93552291
72MP0002733_abnormal_thermal_nociception0.92263710
73MP0003786_premature_aging0.91646231
74MP0009785_altered_susceptibility_to0.90511111
75MP0003119_abnormal_digestive_system0.90217460
76MP0005410_abnormal_fertilization0.90177137
77MP0005195_abnormal_posterior_eye0.87042093
78MP0001984_abnormal_olfaction0.86959318
79MP0003806_abnormal_nucleotide_metabolis0.86671280
80MP0002557_abnormal_social/conspecific_i0.86498145
81MP0002928_abnormal_bile_duct0.85267157
82MP0002184_abnormal_innervation0.85182902
83MP0001501_abnormal_sleep_pattern0.84414126
84MP0000230_abnormal_systemic_arterial0.82059641
85MP0005636_abnormal_mineral_homeostasis0.80726151
86MP0000685_abnormal_immune_system0.80685526
87MP0002752_abnormal_somatic_nervous0.80592974
88MP0000647_abnormal_sebaceous_gland0.80475644
89MP0005085_abnormal_gallbladder_physiolo0.78757886
90MP0005499_abnormal_olfactory_system0.78717140
91MP0005394_taste/olfaction_phenotype0.78717140
92MP0005423_abnormal_somatic_nervous0.78472550
93MP0000026_abnormal_inner_ear0.78082023
94MP0003567_abnormal_fetal_cardiomyocyte0.77258570
95MP0002095_abnormal_skin_pigmentation0.76766143
96MP0009764_decreased_sensitivity_to0.76047412
97MP0000049_abnormal_middle_ear0.75772921
98MP0002572_abnormal_emotion/affect_behav0.75396792
99MP0002006_tumorigenesis0.74065315
100MP0001790_abnormal_immune_system0.73350120

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.94483165
2Pancreatic cysts (HP:0001737)3.68168460
3True hermaphroditism (HP:0010459)3.63310172
43-Methylglutaconic aciduria (HP:0003535)3.59548946
5Acute encephalopathy (HP:0006846)3.49324639
6Mitochondrial inheritance (HP:0001427)3.48227627
7Abnormal mitochondria in muscle tissue (HP:0008316)3.41925566
8Pancreatic fibrosis (HP:0100732)3.39935944
9Nephronophthisis (HP:0000090)3.38384008
10Progressive macrocephaly (HP:0004481)3.31916395
11Absent rod-and cone-mediated responses on ERG (HP:0007688)3.29573426
12Increased CSF lactate (HP:0002490)3.29420024
13Molar tooth sign on MRI (HP:0002419)3.29029728
14Abnormality of midbrain morphology (HP:0002418)3.29029728
15Increased hepatocellular lipid droplets (HP:0006565)3.11847012
16Type II lissencephaly (HP:0007260)3.09895285
17Methylmalonic acidemia (HP:0002912)3.07666218
18Lipid accumulation in hepatocytes (HP:0006561)2.98135617
19Abnormality of cells of the erythroid lineage (HP:0012130)2.91939393
20Hepatocellular necrosis (HP:0001404)2.80029900
21Abnormal rod and cone electroretinograms (HP:0008323)2.79644922
22Absent/shortened dynein arms (HP:0200106)2.77883945
23Dynein arm defect of respiratory motile cilia (HP:0012255)2.77883945
24Abnormality of the renal medulla (HP:0100957)2.71784060
25IgG deficiency (HP:0004315)2.68425521
26Abolished electroretinogram (ERG) (HP:0000550)2.67194000
27Reticulocytopenia (HP:0001896)2.64387357
28Abnormal number of erythroid precursors (HP:0012131)2.62673463
29Cerebral edema (HP:0002181)2.59361422
30Congenital stationary night blindness (HP:0007642)2.57560756
31Hepatic necrosis (HP:0002605)2.54427663
32Hyperglycinemia (HP:0002154)2.52115858
33Medial flaring of the eyebrow (HP:0010747)2.50367810
34Abnormality of the renal cortex (HP:0011035)2.42346649
35Methylmalonic aciduria (HP:0012120)2.41321362
36Decreased central vision (HP:0007663)2.41112481
37Optic disc pallor (HP:0000543)2.40750193
38Renal Fanconi syndrome (HP:0001994)2.38318374
39Macrocytic anemia (HP:0001972)2.37052751
40Abnormality of the labia minora (HP:0012880)2.35984276
41Increased serum lactate (HP:0002151)2.31962133
42Cystic liver disease (HP:0006706)2.29295919
43Chronic hepatic failure (HP:0100626)2.24761479
44Stomatitis (HP:0010280)2.21937237
45Attenuation of retinal blood vessels (HP:0007843)2.21901900
46Congenital, generalized hypertrichosis (HP:0004540)2.21307560
47Pendular nystagmus (HP:0012043)2.18926029
48Abnormal respiratory epithelium morphology (HP:0012253)2.18743354
49Abnormal respiratory motile cilium morphology (HP:0005938)2.18743354
50Sclerocornea (HP:0000647)2.18730296
51Lactic acidosis (HP:0003128)2.16860097
52Cerebellar dysplasia (HP:0007033)2.15434432
53Abnormality of the pons (HP:0007361)2.14780944
54Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.14621538
55Aplasia/hypoplasia of the uterus (HP:0008684)2.14170400
56Renal cortical cysts (HP:0000803)2.12576045
57Male pseudohermaphroditism (HP:0000037)2.10005857
58Bile duct proliferation (HP:0001408)2.07356503
59Abnormal biliary tract physiology (HP:0012439)2.07356503
60Hypoplasia of the uterus (HP:0000013)2.05498238
61Hypoplasia of the pons (HP:0012110)2.04791014
62Lethargy (HP:0001254)2.03485388
63Increased intramyocellular lipid droplets (HP:0012240)2.01408871
64Decreased electroretinogram (ERG) amplitude (HP:0000654)1.99447330
65Type 2 muscle fiber atrophy (HP:0003554)1.97311571
66Exertional dyspnea (HP:0002875)1.97031691
67Absent thumb (HP:0009777)1.96384894
68Septo-optic dysplasia (HP:0100842)1.96358537
69Abnormal ciliary motility (HP:0012262)1.95915186
70Anencephaly (HP:0002323)1.94779290
71Abnormal respiratory motile cilium physiology (HP:0012261)1.93983474
72Glycosuria (HP:0003076)1.90536615
73Abnormality of urine glucose concentration (HP:0011016)1.90536615
74Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.88183258
75Gait imbalance (HP:0002141)1.88102258
76Abnormality of the vitamin B12 metabolism (HP:0004341)1.88095067
77Congenital primary aphakia (HP:0007707)1.88004557
78Abnormality of alanine metabolism (HP:0010916)1.86954537
79Hyperalaninemia (HP:0003348)1.86954537
80Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.86954537
81Colon cancer (HP:0003003)1.85701313
82Aplasia/Hypoplasia of the tongue (HP:0010295)1.85549317
83Decreased activity of mitochondrial respiratory chain (HP:0008972)1.84759809
84Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.84759809
85Hypoplasia of the ulna (HP:0003022)1.84705564
86Keratoconus (HP:0000563)1.84263404
87Increased corneal curvature (HP:0100692)1.84263404
88Elevated erythrocyte sedimentation rate (HP:0003565)1.83453826
89Abnormality of renal resorption (HP:0011038)1.82676453
90Tubular atrophy (HP:0000092)1.82213698
91Optic nerve hypoplasia (HP:0000609)1.81075549
92Abnormality of vitamin B metabolism (HP:0004340)1.80228952
93Abnormality of DNA repair (HP:0003254)1.79974348
94Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77684776
95Oligodactyly (hands) (HP:0001180)1.75952094
96Congenital hepatic fibrosis (HP:0002612)1.75773550
97Leukodystrophy (HP:0002415)1.75155062
98Abnormality of glycine metabolism (HP:0010895)1.74866237
99Abnormality of serine family amino acid metabolism (HP:0010894)1.74866237
100Growth hormone deficiency (HP:0000824)1.73044206

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK13.00674429
2MAP4K22.98057765
3FRK2.67920528
4GRK12.63245321
5ZAK2.57187647
6WNK32.53691729
7TXK2.50079113
8ADRBK22.50049908
9NUAK12.47049879
10WNK42.28243856
11STK162.15844836
12CDK192.11931725
13TAOK32.07939305
14BCKDK2.02196343
15PINK11.94350501
16MAP3K121.93777127
17BMPR1B1.88819649
18MST41.55897377
19TIE11.53762719
20VRK21.43564502
21TEC1.42378100
22OXSR11.35213072
23VRK11.33720111
24DYRK21.28117602
25INSRR1.28030027
26EIF2AK31.26909902
27TRIM281.24396418
28MAPK131.19955030
29STK391.16399938
30KIT1.13668992
31MAP3K41.13662881
32TNIK1.10286626
33ACVR1B1.10012113
34PLK41.07968656
35CASK1.04603846
36FLT31.03871132
37TSSK61.03213376
38NEK11.02005622
39ERBB30.99205060
40MAPK150.91592683
41ITK0.89731419
42MYLK0.89488315
43IKBKB0.89254677
44DAPK20.85165251
45NME10.82218496
46PRKCQ0.81257816
47PLK30.79613684
48MKNK10.75619789
49PASK0.75323639
50PHKG20.74488500
51PHKG10.74488500
52MKNK20.74290195
53MAP2K20.73718764
54CAMKK20.72611918
55CSNK1G20.72486813
56PAK30.72121779
57OBSCN0.71392492
58SIK20.68818988
59ADRBK10.68282208
60GRK60.66668777
61MUSK0.66610250
62BMPR20.65403471
63CSNK1G30.65389678
64TAF10.64956974
65EPHA40.64941594
66CSF1R0.64903918
67PRKCE0.64653541
68MAP2K70.64439751
69PBK0.62680399
70MAP4K10.62235189
71IKBKE0.60495633
72PRKCG0.60493878
73BTK0.59054329
74FES0.58977265
75ATR0.57152078
76NEK20.56236062
77CSNK1G10.55680326
78RPS6KA50.55357716
79MATK0.55033355
80KDR0.53793989
81SYK0.53267830
82PRKACA0.49709566
83SCYL20.49446698
84TGFBR10.48442199
85PLK20.48313138
86EIF2AK20.47471081
87DAPK30.47162886
88LCK0.45364872
89CAMK10.45104350
90CSNK2A10.43706241
91GRK70.42964259
92PRKCA0.42799597
93CSNK2A20.42748538
94LYN0.42543516
95PIK3CA0.41341021
96CSNK1A1L0.40876372
97IGF1R0.40567873
98BUB10.40230190
99BCR0.39995206
100CAMK2A0.39893394

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.71003515
2Oxidative phosphorylation_Homo sapiens_hsa001903.48344626
3Asthma_Homo sapiens_hsa053103.26409356
4Protein export_Homo sapiens_hsa030603.22568891
5Parkinsons disease_Homo sapiens_hsa050122.78086170
6Proteasome_Homo sapiens_hsa030502.69286005
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.52491866
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.46812095
9Allograft rejection_Homo sapiens_hsa053302.22576406
10Autoimmune thyroid disease_Homo sapiens_hsa053202.07682661
11Linoleic acid metabolism_Homo sapiens_hsa005911.98931474
12RNA polymerase_Homo sapiens_hsa030201.90171419
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.81836290
14Homologous recombination_Homo sapiens_hsa034401.80588560
15Type I diabetes mellitus_Homo sapiens_hsa049401.79844781
16Alzheimers disease_Homo sapiens_hsa050101.77149455
17Graft-versus-host disease_Homo sapiens_hsa053321.73548523
18RNA degradation_Homo sapiens_hsa030181.71100145
19Huntingtons disease_Homo sapiens_hsa050161.71065790
20Basal transcription factors_Homo sapiens_hsa030221.68246862
21Phototransduction_Homo sapiens_hsa047441.67352076
22Propanoate metabolism_Homo sapiens_hsa006401.60809765
23Cardiac muscle contraction_Homo sapiens_hsa042601.56643046
24One carbon pool by folate_Homo sapiens_hsa006701.55681197
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52049841
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.49491196
27Primary immunodeficiency_Homo sapiens_hsa053401.42853809
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.40956319
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.39785183
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37506611
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34163875
32Fanconi anemia pathway_Homo sapiens_hsa034601.32313513
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27598343
34Arachidonic acid metabolism_Homo sapiens_hsa005901.13961268
35Tryptophan metabolism_Homo sapiens_hsa003801.11600675
36Peroxisome_Homo sapiens_hsa041461.11062865
37Ether lipid metabolism_Homo sapiens_hsa005651.07863986
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07157471
39Caffeine metabolism_Homo sapiens_hsa002321.06813262
40Nitrogen metabolism_Homo sapiens_hsa009101.03011093
41Rheumatoid arthritis_Homo sapiens_hsa053231.03009381
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02464336
43Nucleotide excision repair_Homo sapiens_hsa034200.99568145
44Nicotine addiction_Homo sapiens_hsa050330.97378206
45Butanoate metabolism_Homo sapiens_hsa006500.97219390
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93259298
47Pyrimidine metabolism_Homo sapiens_hsa002400.92944783
48Antigen processing and presentation_Homo sapiens_hsa046120.90146083
49Primary bile acid biosynthesis_Homo sapiens_hsa001200.88230075
50Mismatch repair_Homo sapiens_hsa034300.86493864
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85698573
52Fat digestion and absorption_Homo sapiens_hsa049750.85281512
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84784870
54Sulfur metabolism_Homo sapiens_hsa009200.83147424
55Purine metabolism_Homo sapiens_hsa002300.83068051
56Chemical carcinogenesis_Homo sapiens_hsa052040.82267628
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.81195112
58Regulation of autophagy_Homo sapiens_hsa041400.78170564
59Collecting duct acid secretion_Homo sapiens_hsa049660.77302842
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.76998023
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73230377
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71567381
63Hematopoietic cell lineage_Homo sapiens_hsa046400.70966440
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70348762
65RNA transport_Homo sapiens_hsa030130.68559082
66Retinol metabolism_Homo sapiens_hsa008300.68318080
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67700656
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67246500
69Metabolic pathways_Homo sapiens_hsa011000.63885900
70Olfactory transduction_Homo sapiens_hsa047400.63271239
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62721549
72Base excision repair_Homo sapiens_hsa034100.61013564
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59032215
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.56660650
75Steroid biosynthesis_Homo sapiens_hsa001000.55757967
76Taste transduction_Homo sapiens_hsa047420.51402582
77Fatty acid elongation_Homo sapiens_hsa000620.50909388
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50546630
79Fatty acid degradation_Homo sapiens_hsa000710.50417009
80Morphine addiction_Homo sapiens_hsa050320.48365132
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45877096
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43276669
83beta-Alanine metabolism_Homo sapiens_hsa004100.42660113
84Sulfur relay system_Homo sapiens_hsa041220.42220167
85Serotonergic synapse_Homo sapiens_hsa047260.40103719
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39513481
87Salivary secretion_Homo sapiens_hsa049700.39348207
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38661598
89Vitamin digestion and absorption_Homo sapiens_hsa049770.37084697
90Folate biosynthesis_Homo sapiens_hsa007900.35987316
91Pyruvate metabolism_Homo sapiens_hsa006200.35919904
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.35587185
93Spliceosome_Homo sapiens_hsa030400.35508087
94Systemic lupus erythematosus_Homo sapiens_hsa053220.34943046
95DNA replication_Homo sapiens_hsa030300.34217388
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32670127
97Ovarian steroidogenesis_Homo sapiens_hsa049130.30338421
98Circadian entrainment_Homo sapiens_hsa047130.29126589
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27232827
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26448012

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