ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.11243569
2	ATP synthesis coupled proton transport (GO:0015986)	5.11243569
3	DNA deamination (GO:0045006)	4.75597118
4	ribosomal small subunit assembly (GO:0000028)	4.72556296
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.67170370
6	protein neddylation (GO:0045116)	4.62248645
7	maturation of SSU-rRNA (GO:0030490)	4.31895104
8	water-soluble vitamin biosynthetic process (GO:0042364)	4.10256117
9	viral transcription (GO:0019083)	4.09769255
10	chaperone-mediated protein transport (GO:0072321)	4.08251348
11	protein complex biogenesis (GO:0070271)	4.07196197
12	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.00543425
13	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.00262943
14	translational termination (GO:0006415)	3.99859075
15	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.99220177
16	NADH dehydrogenase complex assembly (GO:0010257)	3.99220177
17	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.99220177
18	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.96293817
19	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.96293817
20	behavioral response to nicotine (GO:0035095)	3.89116281
21	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.81809569
22	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.78228100
23	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.77637979
24	cotranslational protein targeting to membrane (GO:0006613)	3.71538361
25	ribosomal large subunit biogenesis (GO:0042273)	3.70511037
26	mitochondrial respiratory chain complex assembly (GO:0033108)	3.69733416
27	protein targeting to ER (GO:0045047)	3.68903980
28	GTP biosynthetic process (GO:0006183)	3.64879875
29	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.64328171
30	preassembly of GPI anchor in ER membrane (GO:0016254)	3.57537123
31	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.56805478
32	protein localization to endoplasmic reticulum (GO:0070972)	3.51988188
33	translational elongation (GO:0006414)	3.51171212
34	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.36610840
35	electron transport chain (GO:0022900)	3.35950419
36	GPI anchor metabolic process (GO:0006505)	3.32389454
37	respiratory electron transport chain (GO:0022904)	3.31850649
38	somite development (GO:0061053)	3.24801137
39	mannosylation (GO:0097502)	3.23183345
40	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.16123205
41	fucose catabolic process (GO:0019317)	3.16083810
42	L-fucose metabolic process (GO:0042354)	3.16083810
43	L-fucose catabolic process (GO:0042355)	3.16083810
44	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.14831613
45	GPI anchor biosynthetic process (GO:0006506)	3.12338293
46	regulation of isotype switching to IgG isotypes (GO:0048302)	3.09959049
47	negative regulation of mast cell activation (GO:0033004)	3.09546038
48	kynurenine metabolic process (GO:0070189)	3.08158421
49	platelet dense granule organization (GO:0060155)	3.04959577
50	viral life cycle (GO:0019058)	2.99990370
51	ATP biosynthetic process (GO:0006754)	2.99026899
52	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.97378227
53	regulation of immunoglobulin secretion (GO:0051023)	2.96550257
54	translation (GO:0006412)	2.96035527
55	positive regulation of prostaglandin secretion (GO:0032308)	2.95886134
56	UTP biosynthetic process (GO:0006228)	2.95756801
57	respiratory chain complex IV assembly (GO:0008535)	2.90803749
58	piRNA metabolic process (GO:0034587)	2.90737611
59	base-excision repair, AP site formation (GO:0006285)	2.89743648
60	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.88646503
61	cellular protein complex disassembly (GO:0043624)	2.88276557
62	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.88051401
63	termination of RNA polymerase III transcription (GO:0006386)	2.88051401
64	translational initiation (GO:0006413)	2.84357160
65	UTP metabolic process (GO:0046051)	2.83858451
66	response to pheromone (GO:0019236)	2.80369314
67	hydrogen ion transmembrane transport (GO:1902600)	2.79837923
68	negative regulation of telomere maintenance (GO:0032205)	2.79271944
69	proteasome assembly (GO:0043248)	2.78836687
70	tRNA processing (GO:0008033)	2.76019338
71	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.74051952
72	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.72601008
73	ribosomal small subunit biogenesis (GO:0042274)	2.69845019
74	cellular component biogenesis (GO:0044085)	2.69695410
75	proton transport (GO:0015992)	2.69641877
76	C-terminal protein lipidation (GO:0006501)	2.65828414
77	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.65373967
78	protein deneddylation (GO:0000338)	2.64935981
79	indole-containing compound catabolic process (GO:0042436)	2.64103339
80	indolalkylamine catabolic process (GO:0046218)	2.64103339
81	tryptophan catabolic process (GO:0006569)	2.64103339
82	hydrogen transport (GO:0006818)	2.63879722
83	ubiquinone biosynthetic process (GO:0006744)	2.61010539
84	cytochrome complex assembly (GO:0017004)	2.60056262
85	endoderm formation (GO:0001706)	2.59663032
86	cullin deneddylation (GO:0010388)	2.59257170
87	regulation of mitotic spindle checkpoint (GO:1903504)	2.58348424
88	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.58348424
89	C-terminal protein amino acid modification (GO:0018410)	2.57002104
90	ubiquinone metabolic process (GO:0006743)	2.56221790
91	protein-cofactor linkage (GO:0018065)	2.54991786
92	auditory receptor cell stereocilium organization (GO:0060088)	2.54194248
93	parturition (GO:0007567)	2.53320861
94	positive regulation of fatty acid transport (GO:2000193)	2.52381161
95	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.51890416
96	peptidyl-histidine modification (GO:0018202)	2.51554176
97	indolalkylamine metabolic process (GO:0006586)	2.47763916
98	protein localization to cilium (GO:0061512)	2.47166071
99	negative regulation of heart rate (GO:0010459)	2.43640327
100	protein polyglutamylation (GO:0018095)	2.42608164

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.67798053
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.38326653
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.14536326
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.04229625
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.95518651
6	VDR_22108803_ChIP-Seq_LS180_Human	2.94589703
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.91061823
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.54524430
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.54005997
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.20935476
11	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.12145872
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.12006010
13	EZH2_22144423_ChIP-Seq_EOC_Human	2.08914170
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.07606365
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.05712581
16	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.04758298
17	EWS_26573619_Chip-Seq_HEK293_Human	2.03602173
18	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.95658723
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.91205719
20	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.91205403
21	MYC_18940864_ChIP-ChIP_HL60_Human	1.90396642
22	ELK1_19687146_ChIP-ChIP_HELA_Human	1.85539396
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.83924848
24	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.80614703
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.80569542
26	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.79893861
27	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.76527653
28	IRF1_19129219_ChIP-ChIP_H3396_Human	1.73719783
29	P300_19829295_ChIP-Seq_ESCs_Human	1.72691728
30	GBX2_23144817_ChIP-Seq_PC3_Human	1.68714404
31	FUS_26573619_Chip-Seq_HEK293_Human	1.65438293
32	FOXP3_21729870_ChIP-Seq_TREG_Human	1.64592746
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.63847585
34	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.57319736
35	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.52975427
36	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.48989985
37	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.48465428
38	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.46935567
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.46174165
40	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.45859622
41	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.44169556
42	CBP_20019798_ChIP-Seq_JUKART_Human	1.44169556
43	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.43762749
44	ER_23166858_ChIP-Seq_MCF-7_Human	1.43209659
45	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.39216857
46	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.39168670
47	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.37946238
48	NANOG_19829295_ChIP-Seq_ESCs_Human	1.36349690
49	SOX2_19829295_ChIP-Seq_ESCs_Human	1.36349690
50	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.36051268
51	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.36051268
52	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.30719091
53	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.27893221
54	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.26666507
55	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.26353105
56	AR_20517297_ChIP-Seq_VCAP_Human	1.24076323
57	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.21189754
58	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.19328615
59	RNF2_27304074_Chip-Seq_NSC_Mouse	1.19114208
60	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.18662501
61	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.18651117
62	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.18542644
63	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.18321265
64	BCAT_22108803_ChIP-Seq_LS180_Human	1.17935354
65	MYC_19829295_ChIP-Seq_ESCs_Human	1.17227440
66	NCOR_22424771_ChIP-Seq_293T_Human	1.17218565
67	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.16222069
68	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.14880982
69	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.11146741
70	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.10843048
71	TCF4_22108803_ChIP-Seq_LS180_Human	1.08373156
72	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.07415232
73	TTF2_22483619_ChIP-Seq_HELA_Human	1.07196909
74	NANOG_20526341_ChIP-Seq_ESCs_Human	1.05574127
75	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.04390982
76	GATA3_26560356_Chip-Seq_TH2_Human	1.04385885
77	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.03573046
78	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.01309171
79	TAF2_19829295_ChIP-Seq_ESCs_Human	1.01127513
80	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.01030070
81	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.00095892
82	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.97673785
83	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.97645666
84	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.96515962
85	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.96151544
86	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.96113011
87	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.95624685
88	HOXB7_26014856_ChIP-Seq_BT474_Human	0.94212326
89	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.94054343
90	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93342922
91	ERG_20517297_ChIP-Seq_VCAP_Human	0.91878262
92	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.91059367
93	ERA_21632823_ChIP-Seq_H3396_Human	0.90502556
94	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.88829529
95	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.88551603
96	P53_22387025_ChIP-Seq_ESCs_Mouse	0.87684941
97	CDX2_22108803_ChIP-Seq_LS180_Human	0.87447688
98	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.87027267
99	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.86974115
100	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.86973797

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.16558690
2	MP0009379_abnormal_foot_pigmentation	3.23045995
3	MP0008877_abnormal_DNA_methylation	2.81619878
4	MP0002102_abnormal_ear_morphology	2.52863720
5	MP0005671_abnormal_response_to	2.43931440
6	MP0002736_abnormal_nociception_after	2.21417367
7	MP0005646_abnormal_pituitary_gland	2.15205808
8	MP0003787_abnormal_imprinting	2.13303772
9	MP0006072_abnormal_retinal_apoptosis	2.12272468
10	MP0002138_abnormal_hepatobiliary_system	2.11420827
11	MP0001968_abnormal_touch/_nociception	2.03216819
12	MP0005645_abnormal_hypothalamus_physiol	1.96825441
13	MP0004142_abnormal_muscle_tone	1.96437700
14	MP0004147_increased_porphyrin_level	1.93723792
15	MP0008875_abnormal_xenobiotic_pharmacok	1.93494745
16	MP0008872_abnormal_physiological_respon	1.91287157
17	MP0004885_abnormal_endolymph	1.87237390
18	MP0001835_abnormal_antigen_presentation	1.82385930
19	MP0005551_abnormal_eye_electrophysiolog	1.73115869
20	MP0003880_abnormal_central_pattern	1.73092922
21	MP0001529_abnormal_vocalization	1.72512950
22	MP0006276_abnormal_autonomic_nervous	1.69027814
23	MP0003195_calcinosis	1.68294806
24	MP0005084_abnormal_gallbladder_morpholo	1.63460407
25	MP0002837_dystrophic_cardiac_calcinosis	1.52436216
26	MP0003122_maternal_imprinting	1.48097316
27	MP0003646_muscle_fatigue	1.47479632
28	MP0001986_abnormal_taste_sensitivity	1.47300100
29	MP0002272_abnormal_nervous_system	1.44459089
30	MP0001293_anophthalmia	1.44040671
31	MP0002163_abnormal_gland_morphology	1.42524360
32	MP0003011_delayed_dark_adaptation	1.42142666
33	MP0002938_white_spotting	1.42070249
34	MP0002277_abnormal_respiratory_mucosa	1.37857974
35	MP0002653_abnormal_ependyma_morphology	1.34669985
36	MP0005389_reproductive_system_phenotype	1.32676792
37	MP0008058_abnormal_DNA_repair	1.30075214
38	MP0008789_abnormal_olfactory_epithelium	1.27683566
39	MP0001188_hyperpigmentation	1.23714513
40	MP0003718_maternal_effect	1.22756425
41	MP0003724_increased_susceptibility_to	1.22317365
42	MP0005253_abnormal_eye_physiology	1.22284403
43	MP0001905_abnormal_dopamine_level	1.20395977
44	MP0000372_irregular_coat_pigmentation	1.20173652
45	MP0003878_abnormal_ear_physiology	1.19703483
46	MP0005377_hearing/vestibular/ear_phenot	1.19703483
47	MP0001919_abnormal_reproductive_system	1.19586640
48	MP0001440_abnormal_grooming_behavior	1.17189696
49	MP0004145_abnormal_muscle_electrophysio	1.17030011
50	MP0005075_abnormal_melanosome_morpholog	1.16637307
51	MP0009745_abnormal_behavioral_response	1.16355625
52	MP0002160_abnormal_reproductive_system	1.15231467
53	MP0008775_abnormal_heart_ventricle	1.13407611
54	MP0000631_abnormal_neuroendocrine_gland	1.12068407
55	MP0001970_abnormal_pain_threshold	1.11575955
56	MP0002876_abnormal_thyroid_physiology	1.11468323
57	MP0002234_abnormal_pharynx_morphology	1.09668847
58	MP0008995_early_reproductive_senescence	1.09154432
59	MP0004133_heterotaxia	1.08949503
60	MP0002735_abnormal_chemical_nociception	1.08024303
61	MP0002822_catalepsy	1.07646934
62	MP0001486_abnormal_startle_reflex	1.04334416
63	MP0003186_abnormal_redox_activity	1.03674753
64	MP0001485_abnormal_pinna_reflex	1.02760878
65	MP0003121_genomic_imprinting	1.01827244
66	MP0005379_endocrine/exocrine_gland_phen	0.99336099
67	MP0000427_abnormal_hair_cycle	0.95776298
68	MP0004742_abnormal_vestibular_system	0.95716554
69	MP0001800_abnormal_humoral_immune	0.95668054
70	MP0001873_stomach_inflammation	0.94109427
71	MP0002148_abnormal_hypersensitivity_rea	0.93552291
72	MP0002733_abnormal_thermal_nociception	0.92263710
73	MP0003786_premature_aging	0.91646231
74	MP0009785_altered_susceptibility_to	0.90511111
75	MP0003119_abnormal_digestive_system	0.90217460
76	MP0005410_abnormal_fertilization	0.90177137
77	MP0005195_abnormal_posterior_eye	0.87042093
78	MP0001984_abnormal_olfaction	0.86959318
79	MP0003806_abnormal_nucleotide_metabolis	0.86671280
80	MP0002557_abnormal_social/conspecific_i	0.86498145
81	MP0002928_abnormal_bile_duct	0.85267157
82	MP0002184_abnormal_innervation	0.85182902
83	MP0001501_abnormal_sleep_pattern	0.84414126
84	MP0000230_abnormal_systemic_arterial	0.82059641
85	MP0005636_abnormal_mineral_homeostasis	0.80726151
86	MP0000685_abnormal_immune_system	0.80685526
87	MP0002752_abnormal_somatic_nervous	0.80592974
88	MP0000647_abnormal_sebaceous_gland	0.80475644
89	MP0005085_abnormal_gallbladder_physiolo	0.78757886
90	MP0005499_abnormal_olfactory_system	0.78717140
91	MP0005394_taste/olfaction_phenotype	0.78717140
92	MP0005423_abnormal_somatic_nervous	0.78472550
93	MP0000026_abnormal_inner_ear	0.78082023
94	MP0003567_abnormal_fetal_cardiomyocyte	0.77258570
95	MP0002095_abnormal_skin_pigmentation	0.76766143
96	MP0009764_decreased_sensitivity_to	0.76047412
97	MP0000049_abnormal_middle_ear	0.75772921
98	MP0002572_abnormal_emotion/affect_behav	0.75396792
99	MP0002006_tumorigenesis	0.74065315
100	MP0001790_abnormal_immune_system	0.73350120

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.94483165
2	Pancreatic cysts (HP:0001737)	3.68168460
3	True hermaphroditism (HP:0010459)	3.63310172
4	3-Methylglutaconic aciduria (HP:0003535)	3.59548946
5	Acute encephalopathy (HP:0006846)	3.49324639
6	Mitochondrial inheritance (HP:0001427)	3.48227627
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.41925566
8	Pancreatic fibrosis (HP:0100732)	3.39935944
9	Nephronophthisis (HP:0000090)	3.38384008
10	Progressive macrocephaly (HP:0004481)	3.31916395
11	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.29573426
12	Increased CSF lactate (HP:0002490)	3.29420024
13	Molar tooth sign on MRI (HP:0002419)	3.29029728
14	Abnormality of midbrain morphology (HP:0002418)	3.29029728
15	Increased hepatocellular lipid droplets (HP:0006565)	3.11847012
16	Type II lissencephaly (HP:0007260)	3.09895285
17	Methylmalonic acidemia (HP:0002912)	3.07666218
18	Lipid accumulation in hepatocytes (HP:0006561)	2.98135617
19	Abnormality of cells of the erythroid lineage (HP:0012130)	2.91939393
20	Hepatocellular necrosis (HP:0001404)	2.80029900
21	Abnormal rod and cone electroretinograms (HP:0008323)	2.79644922
22	Absent/shortened dynein arms (HP:0200106)	2.77883945
23	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.77883945
24	Abnormality of the renal medulla (HP:0100957)	2.71784060
25	IgG deficiency (HP:0004315)	2.68425521
26	Abolished electroretinogram (ERG) (HP:0000550)	2.67194000
27	Reticulocytopenia (HP:0001896)	2.64387357
28	Abnormal number of erythroid precursors (HP:0012131)	2.62673463
29	Cerebral edema (HP:0002181)	2.59361422
30	Congenital stationary night blindness (HP:0007642)	2.57560756
31	Hepatic necrosis (HP:0002605)	2.54427663
32	Hyperglycinemia (HP:0002154)	2.52115858
33	Medial flaring of the eyebrow (HP:0010747)	2.50367810
34	Abnormality of the renal cortex (HP:0011035)	2.42346649
35	Methylmalonic aciduria (HP:0012120)	2.41321362
36	Decreased central vision (HP:0007663)	2.41112481
37	Optic disc pallor (HP:0000543)	2.40750193
38	Renal Fanconi syndrome (HP:0001994)	2.38318374
39	Macrocytic anemia (HP:0001972)	2.37052751
40	Abnormality of the labia minora (HP:0012880)	2.35984276
41	Increased serum lactate (HP:0002151)	2.31962133
42	Cystic liver disease (HP:0006706)	2.29295919
43	Chronic hepatic failure (HP:0100626)	2.24761479
44	Stomatitis (HP:0010280)	2.21937237
45	Attenuation of retinal blood vessels (HP:0007843)	2.21901900
46	Congenital, generalized hypertrichosis (HP:0004540)	2.21307560
47	Pendular nystagmus (HP:0012043)	2.18926029
48	Abnormal respiratory epithelium morphology (HP:0012253)	2.18743354
49	Abnormal respiratory motile cilium morphology (HP:0005938)	2.18743354
50	Sclerocornea (HP:0000647)	2.18730296
51	Lactic acidosis (HP:0003128)	2.16860097
52	Cerebellar dysplasia (HP:0007033)	2.15434432
53	Abnormality of the pons (HP:0007361)	2.14780944
54	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.14621538
55	Aplasia/hypoplasia of the uterus (HP:0008684)	2.14170400
56	Renal cortical cysts (HP:0000803)	2.12576045
57	Male pseudohermaphroditism (HP:0000037)	2.10005857
58	Bile duct proliferation (HP:0001408)	2.07356503
59	Abnormal biliary tract physiology (HP:0012439)	2.07356503
60	Hypoplasia of the uterus (HP:0000013)	2.05498238
61	Hypoplasia of the pons (HP:0012110)	2.04791014
62	Lethargy (HP:0001254)	2.03485388
63	Increased intramyocellular lipid droplets (HP:0012240)	2.01408871
64	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.99447330
65	Type 2 muscle fiber atrophy (HP:0003554)	1.97311571
66	Exertional dyspnea (HP:0002875)	1.97031691
67	Absent thumb (HP:0009777)	1.96384894
68	Septo-optic dysplasia (HP:0100842)	1.96358537
69	Abnormal ciliary motility (HP:0012262)	1.95915186
70	Anencephaly (HP:0002323)	1.94779290
71	Abnormal respiratory motile cilium physiology (HP:0012261)	1.93983474
72	Glycosuria (HP:0003076)	1.90536615
73	Abnormality of urine glucose concentration (HP:0011016)	1.90536615
74	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.88183258
75	Gait imbalance (HP:0002141)	1.88102258
76	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.88095067
77	Congenital primary aphakia (HP:0007707)	1.88004557
78	Abnormality of alanine metabolism (HP:0010916)	1.86954537
79	Hyperalaninemia (HP:0003348)	1.86954537
80	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.86954537
81	Colon cancer (HP:0003003)	1.85701313
82	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.85549317
83	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.84759809
84	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.84759809
85	Hypoplasia of the ulna (HP:0003022)	1.84705564
86	Keratoconus (HP:0000563)	1.84263404
87	Increased corneal curvature (HP:0100692)	1.84263404
88	Elevated erythrocyte sedimentation rate (HP:0003565)	1.83453826
89	Abnormality of renal resorption (HP:0011038)	1.82676453
90	Tubular atrophy (HP:0000092)	1.82213698
91	Optic nerve hypoplasia (HP:0000609)	1.81075549
92	Abnormality of vitamin B metabolism (HP:0004340)	1.80228952
93	Abnormality of DNA repair (HP:0003254)	1.79974348
94	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.77684776
95	Oligodactyly (hands) (HP:0001180)	1.75952094
96	Congenital hepatic fibrosis (HP:0002612)	1.75773550
97	Leukodystrophy (HP:0002415)	1.75155062
98	Abnormality of serine family amino acid metabolism (HP:0010894)	1.74866237
99	Abnormality of glycine metabolism (HP:0010895)	1.74866237
100	Growth hormone deficiency (HP:0000824)	1.73044206

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	3.00674429
2	MAP4K2	2.98057765
3	FRK	2.67920528
4	GRK1	2.63245321
5	ZAK	2.57187647
6	WNK3	2.53691729
7	TXK	2.50079113
8	ADRBK2	2.50049908
9	NUAK1	2.47049879
10	WNK4	2.28243856
11	STK16	2.15844836
12	CDK19	2.11931725
13	TAOK3	2.07939305
14	BCKDK	2.02196343
15	PINK1	1.94350501
16	MAP3K12	1.93777127
17	BMPR1B	1.88819649
18	MST4	1.55897377
19	TIE1	1.53762719
20	VRK2	1.43564502
21	TEC	1.42378100
22	OXSR1	1.35213072
23	VRK1	1.33720111
24	DYRK2	1.28117602
25	INSRR	1.28030027
26	EIF2AK3	1.26909902
27	TRIM28	1.24396418
28	MAPK13	1.19955030
29	STK39	1.16399938
30	KIT	1.13668992
31	MAP3K4	1.13662881
32	TNIK	1.10286626
33	ACVR1B	1.10012113
34	PLK4	1.07968656
35	CASK	1.04603846
36	FLT3	1.03871132
37	TSSK6	1.03213376
38	NEK1	1.02005622
39	ERBB3	0.99205060
40	MAPK15	0.91592683
41	ITK	0.89731419
42	MYLK	0.89488315
43	IKBKB	0.89254677
44	DAPK2	0.85165251
45	NME1	0.82218496
46	PRKCQ	0.81257816
47	PLK3	0.79613684
48	MKNK1	0.75619789
49	PASK	0.75323639
50	PHKG1	0.74488500
51	PHKG2	0.74488500
52	MKNK2	0.74290195
53	MAP2K2	0.73718764
54	CAMKK2	0.72611918
55	CSNK1G2	0.72486813
56	PAK3	0.72121779
57	OBSCN	0.71392492
58	SIK2	0.68818988
59	ADRBK1	0.68282208
60	GRK6	0.66668777
61	MUSK	0.66610250
62	BMPR2	0.65403471
63	CSNK1G3	0.65389678
64	TAF1	0.64956974
65	EPHA4	0.64941594
66	CSF1R	0.64903918
67	PRKCE	0.64653541
68	MAP2K7	0.64439751
69	PBK	0.62680399
70	MAP4K1	0.62235189
71	IKBKE	0.60495633
72	PRKCG	0.60493878
73	BTK	0.59054329
74	FES	0.58977265
75	ATR	0.57152078
76	NEK2	0.56236062
77	CSNK1G1	0.55680326
78	RPS6KA5	0.55357716
79	MATK	0.55033355
80	KDR	0.53793989
81	SYK	0.53267830
82	PRKACA	0.49709566
83	SCYL2	0.49446698
84	TGFBR1	0.48442199
85	PLK2	0.48313138
86	EIF2AK2	0.47471081
87	DAPK3	0.47162886
88	LCK	0.45364872
89	CAMK1	0.45104350
90	CSNK2A1	0.43706241
91	GRK7	0.42964259
92	PRKCA	0.42799597
93	CSNK2A2	0.42748538
94	LYN	0.42543516
95	PIK3CA	0.41341021
96	CSNK1A1L	0.40876372
97	IGF1R	0.40567873
98	BUB1	0.40230190
99	BCR	0.39995206
100	CAMK2A	0.39893394

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.71003515
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.48344626
3	Asthma_Homo sapiens_hsa05310	3.26409356
4	Protein export_Homo sapiens_hsa03060	3.22568891
5	Parkinsons disease_Homo sapiens_hsa05012	2.78086170
6	Proteasome_Homo sapiens_hsa03050	2.69286005
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.52491866
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.46812095
9	Allograft rejection_Homo sapiens_hsa05330	2.22576406
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.07682661
11	Linoleic acid metabolism_Homo sapiens_hsa00591	1.98931474
12	RNA polymerase_Homo sapiens_hsa03020	1.90171419
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.81836290
14	Homologous recombination_Homo sapiens_hsa03440	1.80588560
15	Type I diabetes mellitus_Homo sapiens_hsa04940	1.79844781
16	Alzheimers disease_Homo sapiens_hsa05010	1.77149455
17	Graft-versus-host disease_Homo sapiens_hsa05332	1.73548523
18	RNA degradation_Homo sapiens_hsa03018	1.71100145
19	Huntingtons disease_Homo sapiens_hsa05016	1.71065790
20	Basal transcription factors_Homo sapiens_hsa03022	1.68246862
21	Phototransduction_Homo sapiens_hsa04744	1.67352076
22	Propanoate metabolism_Homo sapiens_hsa00640	1.60809765
23	Cardiac muscle contraction_Homo sapiens_hsa04260	1.56643046
24	One carbon pool by folate_Homo sapiens_hsa00670	1.55681197
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.52049841
26	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.49491196
27	Primary immunodeficiency_Homo sapiens_hsa05340	1.42853809
28	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.40956319
29	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.39785183
30	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.37506611
31	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.34163875
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.32313513
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.27598343
34	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.13961268
35	Tryptophan metabolism_Homo sapiens_hsa00380	1.11600675
36	Peroxisome_Homo sapiens_hsa04146	1.11062865
37	Ether lipid metabolism_Homo sapiens_hsa00565	1.07863986
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.07157471
39	Caffeine metabolism_Homo sapiens_hsa00232	1.06813262
40	Nitrogen metabolism_Homo sapiens_hsa00910	1.03011093
41	Rheumatoid arthritis_Homo sapiens_hsa05323	1.03009381
42	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.02464336
43	Nucleotide excision repair_Homo sapiens_hsa03420	0.99568145
44	Nicotine addiction_Homo sapiens_hsa05033	0.97378206
45	Butanoate metabolism_Homo sapiens_hsa00650	0.97219390
46	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.93259298
47	Pyrimidine metabolism_Homo sapiens_hsa00240	0.92944783
48	Antigen processing and presentation_Homo sapiens_hsa04612	0.90146083
49	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.88230075
50	Mismatch repair_Homo sapiens_hsa03430	0.86493864
51	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.85698573
52	Fat digestion and absorption_Homo sapiens_hsa04975	0.85281512
53	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.84784870
54	Sulfur metabolism_Homo sapiens_hsa00920	0.83147424
55	Purine metabolism_Homo sapiens_hsa00230	0.83068051
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.82267628
57	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.81195112
58	Regulation of autophagy_Homo sapiens_hsa04140	0.78170564
59	Collecting duct acid secretion_Homo sapiens_hsa04966	0.77302842
60	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.76998023
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.73230377
62	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.71567381
63	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.70966440
64	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.70348762
65	RNA transport_Homo sapiens_hsa03013	0.68559082
66	Retinol metabolism_Homo sapiens_hsa00830	0.68318080
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.67700656
68	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.67246500
69	Metabolic pathways_Homo sapiens_hsa01100	0.63885900
70	Olfactory transduction_Homo sapiens_hsa04740	0.63271239
71	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.62721549
72	Base excision repair_Homo sapiens_hsa03410	0.61013564
73	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.59032215
74	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.56660650
75	Steroid biosynthesis_Homo sapiens_hsa00100	0.55757967
76	Taste transduction_Homo sapiens_hsa04742	0.51402582
77	Fatty acid elongation_Homo sapiens_hsa00062	0.50909388
78	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.50546630
79	Fatty acid degradation_Homo sapiens_hsa00071	0.50417009
80	Morphine addiction_Homo sapiens_hsa05032	0.48365132
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.45877096
82	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.43276669
83	beta-Alanine metabolism_Homo sapiens_hsa00410	0.42660113
84	Sulfur relay system_Homo sapiens_hsa04122	0.42220167
85	Serotonergic synapse_Homo sapiens_hsa04726	0.40103719
86	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.39513481
87	Salivary secretion_Homo sapiens_hsa04970	0.39348207
88	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.38661598
89	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.37084697
90	Folate biosynthesis_Homo sapiens_hsa00790	0.35987316
91	Pyruvate metabolism_Homo sapiens_hsa00620	0.35919904
92	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.35587185
93	Spliceosome_Homo sapiens_hsa03040	0.35508087
94	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.34943046
95	DNA replication_Homo sapiens_hsa03030	0.34217388
96	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.32670127
97	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.30338421
98	Circadian entrainment_Homo sapiens_hsa04713	0.29126589
99	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.27232827
100	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.26448012

RPL5P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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