RPL5P10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.89379462
2behavioral response to nicotine (GO:0035095)4.35029984
3viral transcription (GO:0019083)4.30999669
4polyamine biosynthetic process (GO:0006596)4.26737083
5maturation of SSU-rRNA (GO:0030490)4.25486397
6translational termination (GO:0006415)4.11063051
7artery development (GO:0060840)4.08847557
8tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.98665265
9RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.98665265
10DNA deamination (GO:0045006)3.94823889
11base-excision repair, AP site formation (GO:0006285)3.91347625
12amine catabolic process (GO:0009310)3.90212883
13cellular biogenic amine catabolic process (GO:0042402)3.90212883
14outer ear morphogenesis (GO:0042473)3.84060004
15translational elongation (GO:0006414)3.82120661
16regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.80443362
17regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.80443362
18piRNA metabolic process (GO:0034587)3.71379477
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.65566911
20cellular biogenic amine biosynthetic process (GO:0042401)3.62835368
21cotranslational protein targeting to membrane (GO:0006613)3.58825510
22polyamine metabolic process (GO:0006595)3.54822740
23protein targeting to ER (GO:0045047)3.54362830
24ubiquinone biosynthetic process (GO:0006744)3.50417989
25icosanoid secretion (GO:0032309)3.50011158
26arachidonic acid secretion (GO:0050482)3.50011158
27amine biosynthetic process (GO:0009309)3.48208270
28reflex (GO:0060004)3.40943736
29ATP synthesis coupled proton transport (GO:0015986)3.40831021
30energy coupled proton transport, down electrochemical gradient (GO:0015985)3.40831021
31establishment of protein localization to endoplasmic reticulum (GO:0072599)3.38206526
32protein localization to endoplasmic reticulum (GO:0070972)3.36462296
33regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.35147910
34ribosomal small subunit biogenesis (GO:0042274)3.34846389
35positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.34693103
36G-protein coupled receptor internalization (GO:0002031)3.31709753
37GTP biosynthetic process (GO:0006183)3.30907597
38water-soluble vitamin biosynthetic process (GO:0042364)3.28121070
39establishment of protein localization to mitochondrial membrane (GO:0090151)3.25115861
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.24039766
41NADH dehydrogenase complex assembly (GO:0010257)3.24039766
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.24039766
43synaptic transmission, dopaminergic (GO:0001963)3.23929315
44regulation of isotype switching to IgG isotypes (GO:0048302)3.22199311
45epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.18633781
46intracellular protein transmembrane import (GO:0044743)3.17415480
47ubiquinone metabolic process (GO:0006743)3.17335532
48negative regulation of sodium ion transport (GO:0010766)3.16533270
49negative regulation of synaptic transmission, GABAergic (GO:0032229)3.15301454
50peptidyl-histidine modification (GO:0018202)3.12725380
51indolalkylamine metabolic process (GO:0006586)3.12457309
52regulation of regulatory T cell differentiation (GO:0045589)3.08701823
53detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.08668736
54adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.07309173
55substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.06839187
56substrate-independent telencephalic tangential migration (GO:0021826)3.06839187
57ribosomal large subunit biogenesis (GO:0042273)3.05747372
58regulation of neurotransmitter uptake (GO:0051580)3.04927606
59viral life cycle (GO:0019058)3.04222575
60mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.02688008
61regulation of interleukin-8 secretion (GO:2000482)3.01444110
62tryptophan metabolic process (GO:0006568)3.01026380
63kynurenine metabolic process (GO:0070189)3.00689553
64cardiovascular system development (GO:0072358)3.00626682
65RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.98499006
66protein complex biogenesis (GO:0070271)2.97556403
67L-fucose metabolic process (GO:0042354)2.95894358
68L-fucose catabolic process (GO:0042355)2.95894358
69fucose catabolic process (GO:0019317)2.95894358
70mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.95885111
71negative regulation of mast cell activation (GO:0033004)2.95848056
72pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.93077524
73cellular protein complex disassembly (GO:0043624)2.89808731
74purine deoxyribonucleotide catabolic process (GO:0009155)2.89022502
75translational initiation (GO:0006413)2.86490598
76regulation of action potential (GO:0098900)2.84892446
77behavioral response to cocaine (GO:0048148)2.84541412
78nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.80811271
79nephron epithelium morphogenesis (GO:0072088)2.79817722
80nephron tubule morphogenesis (GO:0072078)2.79817722
81UTP biosynthetic process (GO:0006228)2.78445648
82negative regulation of telomere maintenance (GO:0032205)2.78237848
83chaperone-mediated protein transport (GO:0072321)2.77948091
84facial nerve structural organization (GO:0021612)2.77821057
85quinone biosynthetic process (GO:1901663)2.75357856
86tryptophan catabolic process (GO:0006569)2.74591350
87indole-containing compound catabolic process (GO:0042436)2.74591350
88indolalkylamine catabolic process (GO:0046218)2.74591350
89mitochondrial respiratory chain complex assembly (GO:0033108)2.74325389
90fatty acid derivative transport (GO:1901571)2.74279075
91icosanoid transport (GO:0071715)2.74279075
92translation (GO:0006412)2.73240500
93protein neddylation (GO:0045116)2.70141984
94regulation of proton transport (GO:0010155)2.69224000
95deoxyribonucleotide catabolic process (GO:0009264)2.69093806
96protein-cofactor linkage (GO:0018065)2.66274101
97L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.65127833
98DNA methylation involved in gamete generation (GO:0043046)2.65041821
99segment specification (GO:0007379)2.65001006
100mannosylation (GO:0097502)2.64108352

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.51656341
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.68663286
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.50285647
4ZNF274_21170338_ChIP-Seq_K562_Hela3.47474742
5EZH2_22144423_ChIP-Seq_EOC_Human3.43783793
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.20259030
7VDR_22108803_ChIP-Seq_LS180_Human3.04465600
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.91355066
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.78974832
10IGF1R_20145208_ChIP-Seq_DFB_Human2.72791491
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.72063375
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.40847282
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.29172163
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.23532395
15VDR_23849224_ChIP-Seq_CD4+_Human2.18250324
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.09934225
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.04454734
18MYC_18940864_ChIP-ChIP_HL60_Human1.90501310
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.80477685
20GATA3_21878914_ChIP-Seq_MCF-7_Human1.76971670
21SRF_21415370_ChIP-Seq_HL-1_Mouse1.72816927
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69290274
23FOXP3_21729870_ChIP-Seq_TREG_Human1.68990132
24TP53_22573176_ChIP-Seq_HFKS_Human1.68253301
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68239249
26PCGF2_27294783_Chip-Seq_NPCs_Mouse1.67168168
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59951137
28ELK1_19687146_ChIP-ChIP_HELA_Human1.56052946
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53850331
30FOXA1_27270436_Chip-Seq_PROSTATE_Human1.51677407
31FOXA1_25329375_ChIP-Seq_VCAP_Human1.51677407
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44890351
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.41275668
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.40586557
35EWS_26573619_Chip-Seq_HEK293_Human1.39074404
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35067435
37ERA_21632823_ChIP-Seq_H3396_Human1.33815744
38TTF2_22483619_ChIP-Seq_HELA_Human1.32361485
39GATA3_26560356_Chip-Seq_TH2_Human1.31499464
40TAF2_19829295_ChIP-Seq_ESCs_Human1.30772973
41AR_20517297_ChIP-Seq_VCAP_Human1.26658057
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25108289
43NANOG_20526341_ChIP-Seq_ESCs_Human1.23068160
44GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23051292
45NANOG_19829295_ChIP-Seq_ESCs_Human1.21262856
46SOX2_19829295_ChIP-Seq_ESCs_Human1.21262856
47CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.21116280
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19004314
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.18109916
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16697262
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14831146
52EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.14830138
53HOXB7_26014856_ChIP-Seq_BT474_Human1.14816496
54AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12446997
55EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11829099
56ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11430913
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10469697
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09822051
59NCOR_22424771_ChIP-Seq_293T_Human1.09180402
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08698983
61CREB1_15753290_ChIP-ChIP_HEK293T_Human1.05221176
62MYC_19829295_ChIP-Seq_ESCs_Human1.05169032
63FOXH1_21741376_ChIP-Seq_EPCs_Human1.04399664
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04278065
65BCAT_22108803_ChIP-Seq_LS180_Human1.04171474
66ER_23166858_ChIP-Seq_MCF-7_Human1.03482645
67P300_19829295_ChIP-Seq_ESCs_Human1.03461715
68TDRD3_21172665_ChIP-Seq_MCF-7_Human1.01467350
69TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00895482
70RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00782824
71KAP1_22055183_ChIP-Seq_ESCs_Mouse0.98408391
72MYC_18358816_ChIP-ChIP_MESCs_Mouse0.98370699
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.96512692
74GABP_19822575_ChIP-Seq_HepG2_Human0.96507772
75FOXH1_21741376_ChIP-Seq_ESCs_Human0.96390985
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95967546
77NFE2_27457419_Chip-Seq_LIVER_Mouse0.94664955
78FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94477033
79IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.94315067
80TCF4_22108803_ChIP-Seq_LS180_Human0.93474757
81IRF1_19129219_ChIP-ChIP_H3396_Human0.92901090
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92836529
83CBP_20019798_ChIP-Seq_JUKART_Human0.92836529
84RAC3_21632823_ChIP-Seq_H3396_Human0.91001101
85P53_21459846_ChIP-Seq_SAOS-2_Human0.90720237
86GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.90593936
87SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90522139
88FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89005406
89OCT4_20526341_ChIP-Seq_ESCs_Human0.87719791
90FOXA1_21572438_ChIP-Seq_LNCaP_Human0.87272097
91REST_21632747_ChIP-Seq_MESCs_Mouse0.86964881
92CEBPB_22108803_ChIP-Seq_LS180_Human0.86688495
93GATA6_21074721_ChIP-Seq_CACO-2_Human0.86005704
94ELK1_22589737_ChIP-Seq_MCF10A_Human0.85285397
95GATA3_26560356_Chip-Seq_TH1_Human0.83995487
96KLF5_20875108_ChIP-Seq_MESCs_Mouse0.83654341
97IKZF1_21737484_ChIP-ChIP_HCT116_Human0.83037984
98FUS_26573619_Chip-Seq_HEK293_Human0.82492981
99CBX2_27304074_Chip-Seq_ESCs_Mouse0.82397826
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.82318551

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition4.98433728
2MP0008872_abnormal_physiological_respon3.38769389
3MP0009379_abnormal_foot_pigmentation3.12183181
4MP0001835_abnormal_antigen_presentation2.86468886
5MP0008875_abnormal_xenobiotic_pharmacok2.83568947
6MP0004142_abnormal_muscle_tone2.53480384
7MP0001873_stomach_inflammation2.50425595
8MP0006292_abnormal_olfactory_placode2.40805694
9MP0006072_abnormal_retinal_apoptosis2.35519616
10MP0002102_abnormal_ear_morphology2.30669968
11MP0008877_abnormal_DNA_methylation2.24256183
12MP0001905_abnormal_dopamine_level2.05099311
13MP0009046_muscle_twitch2.03189295
14MP0005671_abnormal_response_to1.87261285
15MP0001440_abnormal_grooming_behavior1.87002655
16MP0003195_calcinosis1.85338442
17MP0000678_abnormal_parathyroid_gland1.84088041
18MP0004885_abnormal_endolymph1.77859327
19MP0001986_abnormal_taste_sensitivity1.68609675
20MP0004145_abnormal_muscle_electrophysio1.68437280
21MP0005645_abnormal_hypothalamus_physiol1.64951301
22MP0005551_abnormal_eye_electrophysiolog1.64691122
23MP0005646_abnormal_pituitary_gland1.60131340
24MP0001968_abnormal_touch/_nociception1.56560291
25MP0002148_abnormal_hypersensitivity_rea1.56250455
26MP0003283_abnormal_digestive_organ1.54697143
27MP0003646_muscle_fatigue1.47785545
28MP0002163_abnormal_gland_morphology1.47670878
29MP0008775_abnormal_heart_ventricle1.42091660
30MP0002876_abnormal_thyroid_physiology1.40572159
31MP0000569_abnormal_digit_pigmentation1.36102728
32MP0003186_abnormal_redox_activity1.35737207
33MP0009764_decreased_sensitivity_to1.35376563
34MP0003718_maternal_effect1.35197201
35MP0000230_abnormal_systemic_arterial1.34447817
36MP0001486_abnormal_startle_reflex1.32226313
37MP0008007_abnormal_cellular_replicative1.30514906
38MP0005075_abnormal_melanosome_morpholog1.29956937
39MP0002733_abnormal_thermal_nociception1.22252775
40MP0002736_abnormal_nociception_after1.21907407
41MP0002735_abnormal_chemical_nociception1.21884654
42MP0002837_dystrophic_cardiac_calcinosis1.20446400
43MP0001502_abnormal_circadian_rhythm1.19117387
44MP0001800_abnormal_humoral_immune1.19054810
45MP0002138_abnormal_hepatobiliary_system1.18863534
46MP0003938_abnormal_ear_development1.16713642
47MP0005253_abnormal_eye_physiology1.16077134
48MP0006276_abnormal_autonomic_nervous1.15987276
49MP0000372_irregular_coat_pigmentation1.14918795
50MP0005410_abnormal_fertilization1.10891442
51MP0004742_abnormal_vestibular_system1.10497385
52MP0002938_white_spotting1.10277483
53MP0009745_abnormal_behavioral_response1.08695499
54MP0002272_abnormal_nervous_system1.07650825
55MP0001790_abnormal_immune_system1.06113742
56MP0005387_immune_system_phenotype1.06113742
57MP0002234_abnormal_pharynx_morphology1.04832216
58MP0003011_delayed_dark_adaptation1.04225264
59MP0002693_abnormal_pancreas_physiology1.04063785
60MP0002277_abnormal_respiratory_mucosa1.00207358
61MP0000049_abnormal_middle_ear0.98828475
62MP0005379_endocrine/exocrine_gland_phen0.98744595
63MP0001501_abnormal_sleep_pattern0.98086129
64MP0001485_abnormal_pinna_reflex0.94567555
65MP0001293_anophthalmia0.94097413
66MP0006082_CNS_inflammation0.93592312
67MP0001970_abnormal_pain_threshold0.93323112
68MP0002067_abnormal_sensory_capabilities0.92326726
69MP0002572_abnormal_emotion/affect_behav0.92195962
70MP0003787_abnormal_imprinting0.90953871
71MP0008058_abnormal_DNA_repair0.89817478
72MP0002166_altered_tumor_susceptibility0.89384283
73MP0002006_tumorigenesis0.88984239
74MP0004133_heterotaxia0.88409084
75MP0005332_abnormal_amino_acid0.87258788
76MP0004147_increased_porphyrin_level0.86963028
77MP0005084_abnormal_gallbladder_morpholo0.85720198
78MP0005389_reproductive_system_phenotype0.84171241
79MP0001663_abnormal_digestive_system0.83369714
80MP0003183_abnormal_peptide_metabolism0.81711260
81MP0002653_abnormal_ependyma_morphology0.81391700
82MP0005000_abnormal_immune_tolerance0.80563325
83MP0003119_abnormal_digestive_system0.79837515
84MP0001984_abnormal_olfaction0.78397522
85MP0005377_hearing/vestibular/ear_phenot0.77615756
86MP0003878_abnormal_ear_physiology0.77615756
87MP0005195_abnormal_posterior_eye0.76998594
88MP0002557_abnormal_social/conspecific_i0.76691275
89MP0003806_abnormal_nucleotide_metabolis0.76651312
90MP0000685_abnormal_immune_system0.76422570
91MP0002723_abnormal_immune_serum0.75418794
92MP0005636_abnormal_mineral_homeostasis0.75049864
93MP0006036_abnormal_mitochondrial_physio0.74868023
94MP0002160_abnormal_reproductive_system0.70651022
95MP0009785_altered_susceptibility_to0.70037253
96MP0003786_premature_aging0.69689567
97MP0003567_abnormal_fetal_cardiomyocyte0.69124920
98MP0002095_abnormal_skin_pigmentation0.68183771
99MP0000427_abnormal_hair_cycle0.68138913
100MP0008995_early_reproductive_senescence0.67689044

Predicted human phenotypes

RankGene SetZ-score
111 pairs of ribs (HP:0000878)5.01573142
2Abnormality of midbrain morphology (HP:0002418)4.32282113
3Molar tooth sign on MRI (HP:0002419)4.32282113
4Broad distal phalanx of finger (HP:0009836)4.25211509
5Pancreatic cysts (HP:0001737)3.73714250
6Pancreatic fibrosis (HP:0100732)3.60046017
7Type II lissencephaly (HP:0007260)3.29816421
8Acute necrotizing encephalopathy (HP:0006965)3.21080984
9Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.20957130
10Abnormality of alanine metabolism (HP:0010916)3.20957130
11Hyperalaninemia (HP:0003348)3.20957130
12Radial bowing (HP:0002986)3.20336299
13Nephronophthisis (HP:0000090)3.15863598
14True hermaphroditism (HP:0010459)3.11720193
15Large for gestational age (HP:0001520)3.10665342
16Stomatitis (HP:0010280)3.09019304
17Reticulocytopenia (HP:0001896)3.05110008
18Absent rod-and cone-mediated responses on ERG (HP:0007688)2.96214321
19Acute encephalopathy (HP:0006846)2.94394522
20Abnormality of cells of the erythroid lineage (HP:0012130)2.90984019
21Abnormal mitochondria in muscle tissue (HP:0008316)2.81032537
22Abolished electroretinogram (ERG) (HP:0000550)2.74105544
23Mitochondrial inheritance (HP:0001427)2.73438380
24Abnormal rod and cone electroretinograms (HP:0008323)2.67914666
25Pendular nystagmus (HP:0012043)2.66311106
26Congenital stationary night blindness (HP:0007642)2.64812629
27Increased corneal curvature (HP:0100692)2.61350384
28Keratoconus (HP:0000563)2.61350384
29Medial flaring of the eyebrow (HP:0010747)2.58892057
30Progressive macrocephaly (HP:0004481)2.56962403
31Congenital, generalized hypertrichosis (HP:0004540)2.56369453
32Dynein arm defect of respiratory motile cilia (HP:0012255)2.53965476
33Absent/shortened dynein arms (HP:0200106)2.53965476
34Irregular vertebral endplates (HP:0003301)2.51668378
35Increased CSF lactate (HP:0002490)2.50207202
36Abnormality of the renal medulla (HP:0100957)2.48409037
37Spinal cord compression (HP:0002176)2.48291437
38Flared iliac wings (HP:0002869)2.46730345
39Abnormality of the vertebral endplates (HP:0005106)2.38064529
40Abnormal number of erythroid precursors (HP:0012131)2.37634634
41Cerebellar dysplasia (HP:0007033)2.36465068
42Cystic liver disease (HP:0006706)2.36328607
43Hyperventilation (HP:0002883)2.35964896
44Methylmalonic acidemia (HP:0002912)2.35301253
45Absent thumb (HP:0009777)2.34133110
46Duplicated collecting system (HP:0000081)2.31859039
47Aplastic anemia (HP:0001915)2.30555749
48Hepatocellular necrosis (HP:0001404)2.29856065
49Abnormality of the renal collecting system (HP:0004742)2.28181851
50Short nail (HP:0001799)2.26637267
51Elevated erythrocyte sedimentation rate (HP:0003565)2.25564605
52Hypoplasia of the radius (HP:0002984)2.21721438
53Missing ribs (HP:0000921)2.20933135
54Furrowed tongue (HP:0000221)2.20737477
55Methylmalonic aciduria (HP:0012120)2.20675792
56Short femoral neck (HP:0100864)2.20391828
57Hepatic necrosis (HP:0002605)2.19008699
58Bicuspid aortic valve (HP:0001647)2.16724932
59Hypoplasia of the ulna (HP:0003022)2.15101655
60Conical tooth (HP:0000698)2.14376961
61Increased hepatocellular lipid droplets (HP:0006565)2.12939093
62Gait imbalance (HP:0002141)2.11380561
63Aplasia/Hypoplasia of the spleen (HP:0010451)2.11340019
64Sclerocornea (HP:0000647)2.11321710
65Congenital primary aphakia (HP:0007707)2.06669307
66Abnormality of the renal cortex (HP:0011035)2.06369907
67Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.03326883
683-Methylglutaconic aciduria (HP:0003535)2.03234092
69Decreased central vision (HP:0007663)2.02529897
70IgG deficiency (HP:0004315)2.02027609
71Increased serum lactate (HP:0002151)2.00039917
72Abnormal respiratory epithelium morphology (HP:0012253)1.99102437
73Abnormal respiratory motile cilium morphology (HP:0005938)1.99102437
74Abnormality of DNA repair (HP:0003254)1.98998452
75Aplasia/hypoplasia of the uterus (HP:0008684)1.97837259
76Lipid accumulation in hepatocytes (HP:0006561)1.96817666
77Brushfield spots (HP:0001088)1.96592663
78Inability to walk (HP:0002540)1.96416174
79Cerebral edema (HP:0002181)1.95744984
80Optic disc pallor (HP:0000543)1.95623397
81Macrocytic anemia (HP:0001972)1.95262721
82Decreased electroretinogram (ERG) amplitude (HP:0000654)1.94106691
83Congenital hepatic fibrosis (HP:0002612)1.90639060
84Nephrogenic diabetes insipidus (HP:0009806)1.89677726
85Supernumerary bones of the axial skeleton (HP:0009144)1.89472924
86Cupped ribs (HP:0000887)1.89452347
87Cleft eyelid (HP:0000625)1.89251193
88Aplasia/Hypoplasia of the ulna (HP:0006495)1.89227265
89Attenuation of retinal blood vessels (HP:0007843)1.87848456
90Colon cancer (HP:0003003)1.87328755
91Mesangial abnormality (HP:0001966)1.85742827
92Forearm undergrowth (HP:0009821)1.84015405
93Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.82597156
94Abnormal ciliary motility (HP:0012262)1.82247672
95Severe muscular hypotonia (HP:0006829)1.81857096
96Anencephaly (HP:0002323)1.80820060
97Hypoplasia of the uterus (HP:0000013)1.78977920
98Microretrognathia (HP:0000308)1.78699172
99Lactic acidosis (HP:0003128)1.78672324
100Type 2 muscle fiber atrophy (HP:0003554)1.76146868

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.40883594
2ADRBK23.65100905
3GRK13.31660480
4ZAK3.18162456
5TAOK32.93448676
6TIE12.93310856
7WNK42.91371935
8ACVR1B2.82914911
9BMPR1B2.61352022
10MAP4K22.58509338
11BCKDK2.39142425
12WNK12.11853338
13FRK2.08626682
14NUAK11.94520154
15TEC1.92304025
16STK161.91488160
17TXK1.90375554
18KIT1.66146053
19NTRK31.61987464
20CDK191.56820124
21NEK11.55941327
22ITK1.47576981
23TGFBR11.37505541
24STK391.37081253
25CSF1R1.35884488
26MAP2K61.32757017
27FLT31.26784283
28MAP3K121.22901950
29PINK11.18384980
30VRK21.16435500
31PAK61.15540500
32CSNK1G31.14735431
33NME11.14014004
34MAP4K11.13932590
35PASK1.09471599
36PHKG11.03655720
37PHKG21.03655720
38PIK3CA1.03007556
39CSNK1G20.99290290
40VRK10.99078766
41OXSR10.97260596
42CSNK1G10.89478098
43PAK30.89427208
44KSR20.87373935
45BTK0.81191134
46DYRK20.78732136
47DAPK20.77691043
48WNK30.76493283
49PTK2B0.76097757
50RPS6KA50.76008223
51ERBB30.75906314
52CSNK1A1L0.75849272
53MAP3K40.73143285
54IKBKB0.70997538
55MUSK0.69524512
56MAP3K110.69269476
57SYK0.68271107
58PRKCH0.64284860
59CAMKK20.61931119
60INSRR0.61824478
61PRKCQ0.60051197
62EPHA40.59537574
63MKNK20.57172051
64PRKCG0.56710461
65MAPK130.56116387
66BMPR20.55962621
67FES0.54669351
68TAF10.54521346
69PBK0.54250681
70ZAP700.52540087
71RAF10.52041717
72PLK40.51849083
73TNK20.51200264
74MST40.50994185
75MKNK10.49638845
76PRKCE0.48912441
77ADRBK10.48701507
78PIK3CG0.48682779
79MAP2K70.48032222
80LCK0.46859986
81LRRK20.46452886
82ATR0.44870502
83LYN0.42876964
84TRPM70.41261592
85CAMKK10.41113189
86IKBKE0.40991075
87KSR10.40022889
88CAMK2D0.39479483
89DAPK30.38888265
90CDK80.37486102
91DAPK10.37120007
92NEK20.36539619
93MAP3K20.35981470
94CSNK1D0.32777792
95CHEK20.32735298
96MAP2K40.32277494
97CSNK2A20.30999021
98PRKACA0.30765527
99EIF2AK30.30513699
100AURKB0.30500604

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.07527186
2Asthma_Homo sapiens_hsa053103.48890149
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.79501857
4Allograft rejection_Homo sapiens_hsa053302.75646428
5Oxidative phosphorylation_Homo sapiens_hsa001902.75123399
6Selenocompound metabolism_Homo sapiens_hsa004502.66718707
7Autoimmune thyroid disease_Homo sapiens_hsa053202.58826156
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.58633808
9Proteasome_Homo sapiens_hsa030502.31924888
10Parkinsons disease_Homo sapiens_hsa050122.29469825
11Graft-versus-host disease_Homo sapiens_hsa053322.06199377
12Type I diabetes mellitus_Homo sapiens_hsa049402.05966899
13Protein export_Homo sapiens_hsa030601.96887713
14RNA polymerase_Homo sapiens_hsa030201.94157599
15Linoleic acid metabolism_Homo sapiens_hsa005911.90582329
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.83367142
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83350602
18Homologous recombination_Homo sapiens_hsa034401.72268311
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.70408596
20RNA degradation_Homo sapiens_hsa030181.69438488
21Peroxisome_Homo sapiens_hsa041461.68782602
22Nitrogen metabolism_Homo sapiens_hsa009101.67330253
23Phototransduction_Homo sapiens_hsa047441.63645735
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.62738056
25Primary immunodeficiency_Homo sapiens_hsa053401.58341626
26Ether lipid metabolism_Homo sapiens_hsa005651.48640534
27One carbon pool by folate_Homo sapiens_hsa006701.47096660
28Cardiac muscle contraction_Homo sapiens_hsa042601.45363747
29Huntingtons disease_Homo sapiens_hsa050161.43933793
30Regulation of autophagy_Homo sapiens_hsa041401.40464603
31Tryptophan metabolism_Homo sapiens_hsa003801.38473908
32Alzheimers disease_Homo sapiens_hsa050101.33510151
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.33223086
34Pyrimidine metabolism_Homo sapiens_hsa002401.27371823
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23885650
36Fanconi anemia pathway_Homo sapiens_hsa034601.23055271
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19012293
38Basal transcription factors_Homo sapiens_hsa030221.16795438
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.12248447
40Arachidonic acid metabolism_Homo sapiens_hsa005901.08828842
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06285579
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03335716
43Sulfur metabolism_Homo sapiens_hsa009201.01965212
44Propanoate metabolism_Homo sapiens_hsa006401.00131601
45Antigen processing and presentation_Homo sapiens_hsa046121.00074376
46Mismatch repair_Homo sapiens_hsa034300.99848892
47Butanoate metabolism_Homo sapiens_hsa006500.99736892
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97889080
49Fat digestion and absorption_Homo sapiens_hsa049750.95139396
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.94428451
51Nucleotide excision repair_Homo sapiens_hsa034200.93465673
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90534644
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85496528
54Hematopoietic cell lineage_Homo sapiens_hsa046400.85198153
55Purine metabolism_Homo sapiens_hsa002300.84182975
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81173559
57Chemical carcinogenesis_Homo sapiens_hsa052040.80000444
58Base excision repair_Homo sapiens_hsa034100.79244635
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77066262
60RNA transport_Homo sapiens_hsa030130.76630674
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74274721
62Glycerolipid metabolism_Homo sapiens_hsa005610.74105565
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73260858
64Caffeine metabolism_Homo sapiens_hsa002320.72749698
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.69921953
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68074323
67Rheumatoid arthritis_Homo sapiens_hsa053230.65759087
68Metabolic pathways_Homo sapiens_hsa011000.62904275
69beta-Alanine metabolism_Homo sapiens_hsa004100.60490664
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60134376
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59647332
72Olfactory transduction_Homo sapiens_hsa047400.58767161
73Taste transduction_Homo sapiens_hsa047420.58134371
74Nicotine addiction_Homo sapiens_hsa050330.56522492
75Spliceosome_Homo sapiens_hsa030400.53083774
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51291496
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48241240
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47557953
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46354933
80DNA replication_Homo sapiens_hsa030300.46061228
81Ovarian steroidogenesis_Homo sapiens_hsa049130.43697873
82T cell receptor signaling pathway_Homo sapiens_hsa046600.43453337
83Retinol metabolism_Homo sapiens_hsa008300.42097283
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41617617
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41185139
86Arginine and proline metabolism_Homo sapiens_hsa003300.41118214
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38536416
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.37925051
89Serotonergic synapse_Homo sapiens_hsa047260.37918750
90Morphine addiction_Homo sapiens_hsa050320.36714279
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.36164380
92Systemic lupus erythematosus_Homo sapiens_hsa053220.35856211
93Staphylococcus aureus infection_Homo sapiens_hsa051500.35825692
94Insulin secretion_Homo sapiens_hsa049110.34657147
95Histidine metabolism_Homo sapiens_hsa003400.33723847
96Pyruvate metabolism_Homo sapiens_hsa006200.31327513
97Steroid biosynthesis_Homo sapiens_hsa001000.30455080
98Fatty acid degradation_Homo sapiens_hsa000710.29463122
99ABC transporters_Homo sapiens_hsa020100.29435096
100Salivary secretion_Homo sapiens_hsa049700.29170565

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