RPL5P11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.64249337
2viral transcription (GO:0019083)6.43594616
3translational termination (GO:0006415)6.19291435
4maturation of SSU-rRNA (GO:0030490)6.07712774
5ribosomal small subunit biogenesis (GO:0042274)5.85051609
6water-soluble vitamin biosynthetic process (GO:0042364)5.55433422
7translational elongation (GO:0006414)5.33764980
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.32201947
9cotranslational protein targeting to membrane (GO:0006613)5.26665306
10protein targeting to ER (GO:0045047)5.21759471
11establishment of protein localization to endoplasmic reticulum (GO:0072599)5.01718792
12protein localization to endoplasmic reticulum (GO:0070972)4.92172442
13viral life cycle (GO:0019058)4.66447898
14cellular protein complex disassembly (GO:0043624)4.60948251
15nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.46395218
16ribosomal large subunit biogenesis (GO:0042273)4.44269940
17behavioral response to nicotine (GO:0035095)4.28381894
18translational initiation (GO:0006413)4.17016315
19DNA deamination (GO:0045006)3.91935510
20protein neddylation (GO:0045116)3.89584362
21maturation of 5.8S rRNA (GO:0000460)3.83426610
22protein complex disassembly (GO:0043241)3.82651045
23macromolecular complex disassembly (GO:0032984)3.62476482
24ribonucleoprotein complex biogenesis (GO:0022613)3.55689033
25cell proliferation in forebrain (GO:0021846)3.54084124
26termination of RNA polymerase III transcription (GO:0006386)3.46194747
27transcription elongation from RNA polymerase III promoter (GO:0006385)3.46194747
28translation (GO:0006412)3.45319597
29tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.43951957
30RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.43951957
31protein targeting to membrane (GO:0006612)3.41444199
32forebrain morphogenesis (GO:0048853)3.35582943
33cellular component biogenesis (GO:0044085)3.28686999
34protein-cofactor linkage (GO:0018065)3.25879775
35nuclear-transcribed mRNA catabolic process (GO:0000956)3.22158241
36pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.21542758
37rRNA catabolic process (GO:0016075)3.15717846
38axoneme assembly (GO:0035082)3.12036144
39interferon-gamma production (GO:0032609)3.11441334
40epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.10898475
41mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.10887268
42mitochondrial respiratory chain complex I assembly (GO:0032981)3.10887268
43NADH dehydrogenase complex assembly (GO:0010257)3.10887268
44establishment of protein localization to mitochondrial membrane (GO:0090151)3.09558350
45GTP biosynthetic process (GO:0006183)3.07442511
46mRNA catabolic process (GO:0006402)3.05559217
47rRNA processing (GO:0006364)3.05278441
48mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.04377210
49rRNA metabolic process (GO:0016072)3.02895957
50ATP synthesis coupled proton transport (GO:0015986)3.02841039
51energy coupled proton transport, down electrochemical gradient (GO:0015985)3.02841039
52positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.98087086
53neuron fate determination (GO:0048664)2.97665155
54ubiquinone biosynthetic process (GO:0006744)2.95612913
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.94993815
56protein complex biogenesis (GO:0070271)2.91987118
57ubiquinone metabolic process (GO:0006743)2.91725568
58negative regulation of telomere maintenance (GO:0032205)2.90874885
59chaperone-mediated protein transport (GO:0072321)2.90086981
60exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.87853533
61regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.86326265
62response to pheromone (GO:0019236)2.85763058
63somite development (GO:0061053)2.85705384
64piRNA metabolic process (GO:0034587)2.76573679
65intraciliary transport (GO:0042073)2.76072987
66epithelial cilium movement (GO:0003351)2.73639814
67glycerophospholipid catabolic process (GO:0046475)2.69966965
68RNA catabolic process (GO:0006401)2.69822151
69response to nitrosative stress (GO:0051409)2.69268997
70detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.66126488
71telencephalon development (GO:0021537)2.63957217
72regulation of cilium movement (GO:0003352)2.62641635
73pyrimidine nucleotide catabolic process (GO:0006244)2.61899581
74positive regulation of T cell apoptotic process (GO:0070234)2.61706246
75L-fucose catabolic process (GO:0042355)2.61480067
76fucose catabolic process (GO:0019317)2.61480067
77L-fucose metabolic process (GO:0042354)2.61480067
78olfactory bulb development (GO:0021772)2.61238411
79vitamin biosynthetic process (GO:0009110)2.61149370
80mitochondrial respiratory chain complex assembly (GO:0033108)2.60850810
81platelet dense granule organization (GO:0060155)2.59210334
82nephron tubule morphogenesis (GO:0072078)2.55378835
83nephron epithelium morphogenesis (GO:0072088)2.55378835
84aldehyde catabolic process (GO:0046185)2.52649758
85positive regulation of protein homooligomerization (GO:0032464)2.52419917
86nonmotile primary cilium assembly (GO:0035058)2.51374740
87protein polyglutamylation (GO:0018095)2.50904241
88regulation of isotype switching to IgG isotypes (GO:0048302)2.50175445
89UTP biosynthetic process (GO:0006228)2.50071917
90regulation of chronic inflammatory response (GO:0002676)2.48520705
91photoreceptor cell maintenance (GO:0045494)2.47108813
92ribosome biogenesis (GO:0042254)2.46295417
93regulation of energy homeostasis (GO:2000505)2.45121908
94spinal cord association neuron differentiation (GO:0021527)2.45083653
95regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.44781136
96pattern specification involved in kidney development (GO:0061004)2.44706601
97detection of light stimulus involved in sensory perception (GO:0050962)2.43660462
98detection of light stimulus involved in visual perception (GO:0050908)2.43660462
99cardiovascular system development (GO:0072358)2.42166134
100regulation of nuclear cell cycle DNA replication (GO:0033262)2.41990900

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.15000035
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.75697392
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.61712033
4VDR_22108803_ChIP-Seq_LS180_Human3.30646471
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.11626234
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.09363542
7ZNF274_21170338_ChIP-Seq_K562_Hela3.01069366
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.75406347
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.46465654
10EWS_26573619_Chip-Seq_HEK293_Human2.13769033
11IGF1R_20145208_ChIP-Seq_DFB_Human2.09790684
12EST1_17652178_ChIP-ChIP_JURKAT_Human1.98349525
13ETS1_20019798_ChIP-Seq_JURKAT_Human1.96805381
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.96098214
15ELF1_17652178_ChIP-ChIP_JURKAT_Human1.86552739
16MYC_18940864_ChIP-ChIP_HL60_Human1.81267065
17FUS_26573619_Chip-Seq_HEK293_Human1.80951772
18MYC_18555785_ChIP-Seq_MESCs_Mouse1.80428804
19BMI1_23680149_ChIP-Seq_NPCS_Mouse1.79119566
20TP53_22573176_ChIP-Seq_HFKS_Human1.77217382
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.70556327
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.69740965
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.68957208
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68927484
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.67701062
26IRF1_19129219_ChIP-ChIP_H3396_Human1.62106180
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59629020
28ELK1_19687146_ChIP-ChIP_HELA_Human1.59387200
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56847946
30VDR_23849224_ChIP-Seq_CD4+_Human1.56483722
31P300_19829295_ChIP-Seq_ESCs_Human1.54303009
32GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.51508945
33MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51404264
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49022796
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46400851
36JARID2_20064375_ChIP-Seq_MESCs_Mouse1.41827411
37GBX2_23144817_ChIP-Seq_PC3_Human1.38055630
38CBP_20019798_ChIP-Seq_JUKART_Human1.35714190
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35714190
40TTF2_22483619_ChIP-Seq_HELA_Human1.34112598
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33233805
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31774424
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30344581
44NCOR_22424771_ChIP-Seq_293T_Human1.29715025
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28452737
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27394780
47ETV2_25802403_ChIP-Seq_MESCs_Mouse1.27241747
48TAF15_26573619_Chip-Seq_HEK293_Human1.26614295
49CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.26335970
50NANOG_20526341_ChIP-Seq_ESCs_Human1.25121931
51FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24418109
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.24418109
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23813740
54REST_21632747_ChIP-Seq_MESCs_Mouse1.23257025
55GATA3_21878914_ChIP-Seq_MCF-7_Human1.21746798
56AUTS2_25519132_ChIP-Seq_293T-REX_Human1.21256185
57FOXP3_21729870_ChIP-Seq_TREG_Human1.20529679
58EZH2_27304074_Chip-Seq_ESCs_Mouse1.18223900
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.18109003
60ER_23166858_ChIP-Seq_MCF-7_Human1.16993283
61EZH2_27294783_Chip-Seq_ESCs_Mouse1.16892670
62TAF2_19829295_ChIP-Seq_ESCs_Human1.16681534
63RNF2_27304074_Chip-Seq_NSC_Mouse1.15547546
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.13334317
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.13210758
66EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11464176
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10678309
68BCAT_22108803_ChIP-Seq_LS180_Human1.09026973
69SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.05792151
70AR_20517297_ChIP-Seq_VCAP_Human1.04288503
71ERA_21632823_ChIP-Seq_H3396_Human1.02764608
72NANOG_19829295_ChIP-Seq_ESCs_Human1.02193654
73SOX2_19829295_ChIP-Seq_ESCs_Human1.02193654
74RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.01088361
75FOXH1_21741376_ChIP-Seq_EPCs_Human1.01074937
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00217033
77TCF4_22108803_ChIP-Seq_LS180_Human0.99446338
78ELK1_22589737_ChIP-Seq_MCF10A_Human0.99206029
79KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97650596
80HOXB7_26014856_ChIP-Seq_BT474_Human0.97609190
81SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96436017
82FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95749467
83SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95538480
84CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94700234
85POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94692543
86POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94511861
87TP63_19390658_ChIP-ChIP_HaCaT_Human0.91630816
88REST_18959480_ChIP-ChIP_MESCs_Mouse0.89632788
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89148490
90WDR5_24793694_ChIP-Seq_LNCAP_Human0.89086520
91TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89063928
92SMAD3_21741376_ChIP-Seq_EPCs_Human0.88887917
93EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87980609
94GATA1_26923725_Chip-Seq_HPCs_Mouse0.87578240
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86809228
96PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.86410733
97STAT3_23295773_ChIP-Seq_U87_Human0.86000372
98TAL1_26923725_Chip-Seq_HPCs_Mouse0.85711428
99TDRD3_21172665_ChIP-Seq_MCF-7_Human0.85431567
100SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.85307574

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology3.87676380
2MP0006292_abnormal_olfactory_placode3.66974318
3MP0008877_abnormal_DNA_methylation3.21450345
4MP0009379_abnormal_foot_pigmentation2.98551164
5MP0003787_abnormal_imprinting2.61278910
6MP0002102_abnormal_ear_morphology2.52940313
7MP0003122_maternal_imprinting2.48515458
8MP0002163_abnormal_gland_morphology2.38281087
9MP0002138_abnormal_hepatobiliary_system2.33733921
10MP0004142_abnormal_muscle_tone2.31520396
11MP0008875_abnormal_xenobiotic_pharmacok2.13600641
12MP0002876_abnormal_thyroid_physiology2.13324147
13MP0002837_dystrophic_cardiac_calcinosis2.11988547
14MP0005084_abnormal_gallbladder_morpholo2.09258032
15MP0006276_abnormal_autonomic_nervous2.07412070
16MP0004145_abnormal_muscle_electrophysio2.02246191
17MP0004885_abnormal_endolymph1.94008958
18MP0003121_genomic_imprinting1.93286996
19MP0006072_abnormal_retinal_apoptosis1.88315267
20MP0001984_abnormal_olfaction1.86959615
21MP0005377_hearing/vestibular/ear_phenot1.82772662
22MP0003878_abnormal_ear_physiology1.82772662
23MP0005551_abnormal_eye_electrophysiolog1.78843949
24MP0001348_abnormal_lacrimal_gland1.73761418
25MP0003646_muscle_fatigue1.72050405
26MP0006054_spinal_hemorrhage1.64645334
27MP0008789_abnormal_olfactory_epithelium1.60338350
28MP0004742_abnormal_vestibular_system1.59105466
29MP0008872_abnormal_physiological_respon1.58257003
30MP0005645_abnormal_hypothalamus_physiol1.55595993
31MP0003123_paternal_imprinting1.54270389
32MP0000049_abnormal_middle_ear1.53715932
33MP0001968_abnormal_touch/_nociception1.48270427
34MP0001986_abnormal_taste_sensitivity1.43504313
35MP0002272_abnormal_nervous_system1.42881100
36MP0005389_reproductive_system_phenotype1.37769544
37MP0005379_endocrine/exocrine_gland_phen1.34168551
38MP0003880_abnormal_central_pattern1.32443193
39MP0000778_abnormal_nervous_system1.31239309
40MP0001873_stomach_inflammation1.30638566
41MP0002234_abnormal_pharynx_morphology1.28591501
42MP0002938_white_spotting1.28201059
43MP0001485_abnormal_pinna_reflex1.27211718
44MP0001188_hyperpigmentation1.22910418
45MP0005499_abnormal_olfactory_system1.22112722
46MP0005394_taste/olfaction_phenotype1.22112722
47MP0000631_abnormal_neuroendocrine_gland1.19482461
48MP0003186_abnormal_redox_activity1.18234370
49MP0002736_abnormal_nociception_after1.17588669
50MP0001501_abnormal_sleep_pattern1.17382951
51MP0001293_anophthalmia1.16286744
52MP0002160_abnormal_reproductive_system1.15938676
53MP0001919_abnormal_reproductive_system1.13845500
54MP0003693_abnormal_embryo_hatching1.10388731
55MP0004084_abnormal_cardiac_muscle1.09194041
56MP0002928_abnormal_bile_duct1.08203808
57MP0002638_abnormal_pupillary_reflex1.07238257
58MP0005646_abnormal_pituitary_gland1.04728982
59MP0009745_abnormal_behavioral_response1.04708335
60MP0000026_abnormal_inner_ear1.04206796
61MP0005253_abnormal_eye_physiology1.03644667
62MP0005195_abnormal_posterior_eye1.02277150
63MP0001529_abnormal_vocalization1.01997904
64MP0002184_abnormal_innervation1.01592171
65MP0003567_abnormal_fetal_cardiomyocyte1.01310217
66MP0008995_early_reproductive_senescence1.00629193
67MP0002557_abnormal_social/conspecific_i1.00049040
68MP0004133_heterotaxia0.99060216
69MP0009046_muscle_twitch0.97726397
70MP0008775_abnormal_heart_ventricle0.96375470
71MP0002572_abnormal_emotion/affect_behav0.94867181
72MP0002277_abnormal_respiratory_mucosa0.94804791
73MP0002693_abnormal_pancreas_physiology0.93958252
74MP0001764_abnormal_homeostasis0.92671897
75MP0001286_abnormal_eye_development0.91993736
76MP0003937_abnormal_limbs/digits/tail_de0.91507750
77MP0000372_irregular_coat_pigmentation0.89464858
78MP0001970_abnormal_pain_threshold0.88320302
79MP0001905_abnormal_dopamine_level0.88169693
80MP0002733_abnormal_thermal_nociception0.87100020
81MP0002095_abnormal_skin_pigmentation0.86932156
82MP0001944_abnormal_pancreas_morphology0.86375426
83MP0002752_abnormal_somatic_nervous0.86097683
84MP0005174_abnormal_tail_pigmentation0.84814770
85MP0003890_abnormal_embryonic-extraembry0.84255903
86MP0005448_abnormal_energy_balance0.83946168
87MP0000427_abnormal_hair_cycle0.83858520
88MP0000685_abnormal_immune_system0.82407692
89MP0009764_decreased_sensitivity_to0.81547520
90MP0008058_abnormal_DNA_repair0.80540481
91MP0002751_abnormal_autonomic_nervous0.76428428
92MP0003195_calcinosis0.76016409
93MP0003283_abnormal_digestive_organ0.75824435
94MP0001963_abnormal_hearing_physiology0.75411465
95MP0002210_abnormal_sex_determination0.75041360
96MP0009250_abnormal_appendicular_skeleto0.74447422
97MP0005220_abnormal_exocrine_pancreas0.73759143
98MP0001486_abnormal_startle_reflex0.73291331
99MP0003252_abnormal_bile_duct0.72179682
100MP0001440_abnormal_grooming_behavior0.71487573

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.41578912
2Chronic hepatic failure (HP:0100626)4.21200916
3Acute necrotizing encephalopathy (HP:0006965)4.15244678
4Pancreatic fibrosis (HP:0100732)3.82685758
5Molar tooth sign on MRI (HP:0002419)3.63509237
6Abnormality of midbrain morphology (HP:0002418)3.63509237
7Acute encephalopathy (HP:0006846)3.57377905
8Pancreatic cysts (HP:0001737)3.49370462
9Abnormal mitochondria in muscle tissue (HP:0008316)3.45622767
10Abnormality of cells of the erythroid lineage (HP:0012130)3.45252101
11Progressive macrocephaly (HP:0004481)3.37970847
12Congenital stationary night blindness (HP:0007642)3.23046330
13Mitochondrial inheritance (HP:0001427)3.17578752
14True hermaphroditism (HP:0010459)3.14699592
15Absent rod-and cone-mediated responses on ERG (HP:0007688)3.09009839
16Macrocytic anemia (HP:0001972)3.02642286
17Stomatitis (HP:0010280)2.95609742
18Increased CSF lactate (HP:0002490)2.91567548
19Dynein arm defect of respiratory motile cilia (HP:0012255)2.89572115
20Absent/shortened dynein arms (HP:0200106)2.89572115
21Nephronophthisis (HP:0000090)2.85808637
22Optic disc pallor (HP:0000543)2.73483399
23Abolished electroretinogram (ERG) (HP:0000550)2.63590727
24Medial flaring of the eyebrow (HP:0010747)2.62733799
25Abnormal rod and cone electroretinograms (HP:0008323)2.59885291
26Cerebral edema (HP:0002181)2.58589358
27Type II lissencephaly (HP:0007260)2.57956353
28Septo-optic dysplasia (HP:0100842)2.57592564
29Increased hepatocellular lipid droplets (HP:0006565)2.53658257
30Constricted visual fields (HP:0001133)2.53604727
31Abnormal number of erythroid precursors (HP:0012131)2.50181419
32Abnormality of the renal medulla (HP:0100957)2.49711260
33Abnormality of the labia minora (HP:0012880)2.45299047
34Aplasia/Hypoplasia of the spleen (HP:0010451)2.44283854
35Cystic liver disease (HP:0006706)2.43726842
36Abnormal respiratory epithelium morphology (HP:0012253)2.40992166
37Abnormal respiratory motile cilium morphology (HP:0005938)2.40992166
38Abnormality of the renal cortex (HP:0011035)2.38608854
39Methylmalonic acidemia (HP:0002912)2.37524177
40Hypoplasia of the pons (HP:0012110)2.35950348
41Asplenia (HP:0001746)2.34534137
42Renal Fanconi syndrome (HP:0001994)2.32939045
43Lipid accumulation in hepatocytes (HP:0006561)2.32903282
44Bony spicule pigmentary retinopathy (HP:0007737)2.31412090
45Pallor (HP:0000980)2.29503335
46Sclerocornea (HP:0000647)2.27374421
47Hypoplasia of the uterus (HP:0000013)2.21459508
48Hyperglycinemia (HP:0002154)2.20522497
49Abnormality of the pons (HP:0007361)2.20067179
50Cerebellar dysplasia (HP:0007033)2.19839375
51Increased serum lactate (HP:0002151)2.19459894
52Stenosis of the external auditory canal (HP:0000402)2.17398641
53Postaxial foot polydactyly (HP:0001830)2.15451777
54Attenuation of retinal blood vessels (HP:0007843)2.14705001
55Hepatocellular necrosis (HP:0001404)2.13580228
56Pendular nystagmus (HP:0012043)2.12534975
57Abnormal drinking behavior (HP:0030082)2.10675921
58Polydipsia (HP:0001959)2.10675921
59Decreased central vision (HP:0007663)2.09306570
60Abnormal hemoglobin (HP:0011902)2.06969316
61Abnormal ciliary motility (HP:0012262)2.06008774
62Polyuria (HP:0000103)2.04051888
63Abnormality of alanine metabolism (HP:0010916)2.03446284
64Hyperalaninemia (HP:0003348)2.03446284
65Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.03446284
66Gait imbalance (HP:0002141)2.01480337
67Tubular atrophy (HP:0000092)2.00825921
68Anencephaly (HP:0002323)1.98276359
69Polyphagia (HP:0002591)1.97560070
70Congenital primary aphakia (HP:0007707)1.97240596
71Aplasia/hypoplasia of the uterus (HP:0008684)1.96199605
72Absent thumb (HP:0009777)1.94867031
73Male pseudohermaphroditism (HP:0000037)1.93306598
74Leukodystrophy (HP:0002415)1.92105489
75Aplasia/Hypoplasia of the tongue (HP:0010295)1.91210753
76Hepatic necrosis (HP:0002605)1.88953532
77Rib fusion (HP:0000902)1.87234701
78Nephrogenic diabetes insipidus (HP:0009806)1.85958777
79Congenital hepatic fibrosis (HP:0002612)1.84317289
80Triphalangeal thumb (HP:0001199)1.83548041
81Inability to walk (HP:0002540)1.83216966
82Depressed nasal ridge (HP:0000457)1.80972471
83Methylmalonic aciduria (HP:0012120)1.80936346
84Abnormal respiratory motile cilium physiology (HP:0012261)1.80397456
85Lethargy (HP:0001254)1.80258745
86Abnormality of DNA repair (HP:0003254)1.79362123
87Glycosuria (HP:0003076)1.79190700
88Abnormality of urine glucose concentration (HP:0011016)1.79190700
89Optic nerve hypoplasia (HP:0000609)1.78427236
90Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.76977837
91Growth hormone deficiency (HP:0000824)1.76003881
92Narrow forehead (HP:0000341)1.75148348
93Retinitis pigmentosa (HP:0000510)1.75040970
94Decreased electroretinogram (ERG) amplitude (HP:0000654)1.73847906
95Abnormality of renal resorption (HP:0011038)1.73691902
96Type 2 muscle fiber atrophy (HP:0003554)1.72493991
97Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72406343
98Abnormality of the phalanges of the 2nd finger (HP:0009541)1.72232053
99Aplasia/Hypoplasia of the uvula (HP:0010293)1.72071684
100Elevated erythrocyte sedimentation rate (HP:0003565)1.67673556

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK4.36710295
2PINK13.57160853
3WNK43.19416584
4MAP4K22.65710798
5FRK2.57301400
6TXK2.52557796
7ADRBK22.45785749
8CAMKK12.29740957
9BCKDK2.16519126
10NUAK12.10457079
11CDK192.09892008
12ZAK2.04510980
13NLK2.03130913
14GRK11.89225395
15DYRK21.83348044
16WNK31.82464800
17CAMKK21.78178899
18STK391.72291296
19TIE11.53574451
20TNIK1.45827679
21MAP4K11.44243496
22PBK1.40394170
23EPHB21.28935997
24MKNK21.26806756
25STK161.23818652
26CSNK1G11.16575225
27OXSR11.15487408
28PIK3CA1.12795946
29TLK11.10614163
30BMPR1B1.09889762
31CDK31.07781673
32VRK11.06912274
33SGK2231.06478101
34SGK4941.06478101
35PRKCQ1.03937355
36LRRK21.02609331
37TRIM280.96835838
38VRK20.93719301
39PRKCG0.93118337
40SGK20.92280466
41MST40.91233083
42MAPK130.90592427
43BCR0.88709249
44NME10.84817899
45PRKD30.84039744
46MKNK10.83255900
47CAMK10.82789510
48BUB10.80409798
49IKBKB0.78838157
50PAK30.78612060
51TAOK30.78466316
52TEC0.73788038
53RPS6KA40.71548324
54EIF2AK30.71537723
55INSRR0.70331723
56PLK30.69863819
57PRKCE0.66745631
58BRSK20.66278960
59SYK0.65584733
60TSSK60.61571765
61ITK0.60226153
62NEK20.59172344
63RPS6KA50.57212795
64CSNK1G20.56285409
65ADRBK10.56030349
66PAK60.55570158
67NTRK20.55263912
68CSNK1G30.54615067
69CDC70.54262490
70DYRK1A0.53816393
71TYRO30.53771942
72CASK0.53378965
73BTK0.50992924
74IKBKE0.50741513
75MARK30.50152925
76PLK10.49630370
77OBSCN0.48399225
78TGFBR10.47975394
79MAP2K60.47854619
80PLK40.47154659
81DAPK20.47104023
82TAF10.46625918
83PRKCI0.45578759
84STK110.45572876
85PRKACA0.45432878
86KIT0.45306978
87CSNK2A20.44331984
88CSNK1A10.43794367
89WNK10.43715528
90PRKCZ0.43194117
91PRKCH0.41580745
92PRKCD0.41283853
93PAK10.40935135
94PRKG10.40415490
95CSNK1A1L0.39800198
96PRKCA0.39538138
97RPS6KA60.39069910
98CAMK2A0.37317857
99PIK3CG0.37014677
100AURKA0.36516692

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.61897231
2Oxidative phosphorylation_Homo sapiens_hsa001903.01629079
3RNA polymerase_Homo sapiens_hsa030202.67973889
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.39907625
5Parkinsons disease_Homo sapiens_hsa050122.37928507
6Linoleic acid metabolism_Homo sapiens_hsa005912.18829721
7Proteasome_Homo sapiens_hsa030502.18103486
8Asthma_Homo sapiens_hsa053102.17987306
9Phototransduction_Homo sapiens_hsa047442.05765138
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.00326170
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.95896014
12Basal transcription factors_Homo sapiens_hsa030221.93642808
13Protein export_Homo sapiens_hsa030601.90617876
14RNA degradation_Homo sapiens_hsa030181.82895414
15Allograft rejection_Homo sapiens_hsa053301.79084553
16Huntingtons disease_Homo sapiens_hsa050161.71222487
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.70953752
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70532335
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.67991868
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.67713261
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66227998
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.63719950
23Cardiac muscle contraction_Homo sapiens_hsa042601.63196157
24Alzheimers disease_Homo sapiens_hsa050101.59754026
25Type I diabetes mellitus_Homo sapiens_hsa049401.57839506
26One carbon pool by folate_Homo sapiens_hsa006701.50205961
27Homologous recombination_Homo sapiens_hsa034401.46898148
28Autoimmune thyroid disease_Homo sapiens_hsa053201.46417662
29Fanconi anemia pathway_Homo sapiens_hsa034601.45063123
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42261777
31Ether lipid metabolism_Homo sapiens_hsa005651.39789032
32Nitrogen metabolism_Homo sapiens_hsa009101.38902842
33Pyrimidine metabolism_Homo sapiens_hsa002401.34699418
34Steroid biosynthesis_Homo sapiens_hsa001001.34553687
35Nicotine addiction_Homo sapiens_hsa050331.23077808
36Propanoate metabolism_Homo sapiens_hsa006401.13596901
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12797843
38Selenocompound metabolism_Homo sapiens_hsa004501.06090134
39Primary immunodeficiency_Homo sapiens_hsa053401.01680013
40Butanoate metabolism_Homo sapiens_hsa006501.00525955
41Olfactory transduction_Homo sapiens_hsa047400.98298509
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97743242
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.95883248
44Arachidonic acid metabolism_Homo sapiens_hsa005900.93447666
45Insulin secretion_Homo sapiens_hsa049110.89644880
46Purine metabolism_Homo sapiens_hsa002300.87813848
47Peroxisome_Homo sapiens_hsa041460.87492535
48Caffeine metabolism_Homo sapiens_hsa002320.86168897
49Steroid hormone biosynthesis_Homo sapiens_hsa001400.83966442
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83951884
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83951757
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.83390214
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82740133
54Cocaine addiction_Homo sapiens_hsa050300.81333390
55Fat digestion and absorption_Homo sapiens_hsa049750.79933479
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75878112
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75529758
58RNA transport_Homo sapiens_hsa030130.74202162
59Taste transduction_Homo sapiens_hsa047420.73998495
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73584042
61Morphine addiction_Homo sapiens_hsa050320.73303575
62Graft-versus-host disease_Homo sapiens_hsa053320.70839316
63Chemical carcinogenesis_Homo sapiens_hsa052040.70362904
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69422010
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68630916
66Sulfur relay system_Homo sapiens_hsa041220.68516690
67Nucleotide excision repair_Homo sapiens_hsa034200.68283126
68Tryptophan metabolism_Homo sapiens_hsa003800.66768548
69Salivary secretion_Homo sapiens_hsa049700.66171635
70Retinol metabolism_Homo sapiens_hsa008300.65753896
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64268317
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63458977
73Ovarian steroidogenesis_Homo sapiens_hsa049130.62166170
74Metabolic pathways_Homo sapiens_hsa011000.61610516
75Hematopoietic cell lineage_Homo sapiens_hsa046400.59775190
76Serotonergic synapse_Homo sapiens_hsa047260.59047520
77Base excision repair_Homo sapiens_hsa034100.58881493
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58579390
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58155035
80Non-homologous end-joining_Homo sapiens_hsa034500.51833655
81Glycerolipid metabolism_Homo sapiens_hsa005610.51481636
82Folate biosynthesis_Homo sapiens_hsa007900.48743927
83Mismatch repair_Homo sapiens_hsa034300.47089854
84Rheumatoid arthritis_Homo sapiens_hsa053230.46626090
85Glutathione metabolism_Homo sapiens_hsa004800.46112345
86Collecting duct acid secretion_Homo sapiens_hsa049660.45246751
87Glutamatergic synapse_Homo sapiens_hsa047240.43625814
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43347473
89Amphetamine addiction_Homo sapiens_hsa050310.38061974
90Fatty acid biosynthesis_Homo sapiens_hsa000610.36998952
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36715829
92T cell receptor signaling pathway_Homo sapiens_hsa046600.34969105
93Thyroid hormone synthesis_Homo sapiens_hsa049180.34854552
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34825550
95Vitamin B6 metabolism_Homo sapiens_hsa007500.33956433
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.25533943
97African trypanosomiasis_Homo sapiens_hsa051430.25485766
98Circadian entrainment_Homo sapiens_hsa047130.22320271
99Circadian rhythm_Homo sapiens_hsa047100.22319145
100Spliceosome_Homo sapiens_hsa030400.21608266

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