RPL5P14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)7.12825887
2viral transcription (GO:0019083)6.98966904
3translational termination (GO:0006415)6.72624509
4ribosomal small subunit assembly (GO:0000028)6.55845977
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.89199537
6cotranslational protein targeting to membrane (GO:0006613)5.83288431
7protein targeting to ER (GO:0045047)5.79691975
8ribosomal small subunit biogenesis (GO:0042274)5.62310354
9establishment of protein localization to endoplasmic reticulum (GO:0072599)5.55518924
10protein localization to endoplasmic reticulum (GO:0070972)5.47153846
11translational elongation (GO:0006414)5.45318006
12ATP synthesis coupled proton transport (GO:0015986)5.38470150
13energy coupled proton transport, down electrochemical gradient (GO:0015985)5.38470150
14cell wall macromolecule metabolic process (GO:0044036)5.37075345
15chaperone-mediated protein transport (GO:0072321)5.20767916
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.12998754
17viral life cycle (GO:0019058)5.11047187
18behavioral response to nicotine (GO:0035095)5.09002895
19cellular protein complex disassembly (GO:0043624)4.97307814
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.83283708
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.35579396
22protein neddylation (GO:0045116)4.27951464
23translational initiation (GO:0006413)4.25690932
24protein complex biogenesis (GO:0070271)4.24975977
25mitochondrial respiratory chain complex I assembly (GO:0032981)4.15897161
26NADH dehydrogenase complex assembly (GO:0010257)4.15897161
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.15897161
28ribosomal large subunit biogenesis (GO:0042273)4.15578832
29mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.11860741
30protein complex disassembly (GO:0043241)4.07543276
31positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.06431546
32protein targeting to membrane (GO:0006612)4.00428057
33regulation of immunoglobulin secretion (GO:0051023)3.91020748
34macromolecular complex disassembly (GO:0032984)3.85726053
35mitochondrial respiratory chain complex assembly (GO:0033108)3.81813188
36nuclear-transcribed mRNA catabolic process (GO:0000956)3.72455981
37electron transport chain (GO:0022900)3.63449006
38respiratory electron transport chain (GO:0022904)3.63159421
39regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.61831353
40translation (GO:0006412)3.60850753
41mRNA catabolic process (GO:0006402)3.51917067
42nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.50498227
43exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.48259500
44establishment of protein localization to mitochondrial membrane (GO:0090151)3.46377720
45nonmotile primary cilium assembly (GO:0035058)3.44999542
46transcription elongation from RNA polymerase III promoter (GO:0006385)3.33830361
47termination of RNA polymerase III transcription (GO:0006386)3.33830361
48regulation of isotype switching to IgG isotypes (GO:0048302)3.31047177
49cell wall macromolecule catabolic process (GO:0016998)3.28141297
50aldehyde catabolic process (GO:0046185)3.26031727
51pattern specification involved in kidney development (GO:0061004)3.24529276
52synaptic transmission, cholinergic (GO:0007271)3.23625422
53phosphate ion transmembrane transport (GO:0035435)3.22711629
54cellular component biogenesis (GO:0044085)3.20317522
55resolution of meiotic recombination intermediates (GO:0000712)3.16896430
56platelet dense granule organization (GO:0060155)3.16847347
57RNA catabolic process (GO:0006401)3.15537310
58ATP biosynthetic process (GO:0006754)3.15065752
59hydrogen ion transmembrane transport (GO:1902600)3.11634076
60purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.10520219
61protein localization to cilium (GO:0061512)3.08796867
62segment specification (GO:0007379)3.06281337
63detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.06151239
64preassembly of GPI anchor in ER membrane (GO:0016254)3.05303147
65epithelial cilium movement (GO:0003351)3.02854463
66cell proliferation in forebrain (GO:0021846)3.02834095
67purine nucleoside triphosphate biosynthetic process (GO:0009145)3.02166433
68neuron fate determination (GO:0048664)2.96973798
69GTP biosynthetic process (GO:0006183)2.96126029
70substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.93617584
71substrate-independent telencephalic tangential migration (GO:0021826)2.93617584
72ribonucleoprotein complex biogenesis (GO:0022613)2.92235494
73negative regulation of response to food (GO:0032096)2.92075521
74negative regulation of appetite (GO:0032099)2.92075521
75regulation of action potential (GO:0098900)2.84886784
76proton transport (GO:0015992)2.84216172
77water-soluble vitamin biosynthetic process (GO:0042364)2.78296104
78establishment of protein localization to membrane (GO:0090150)2.77518524
79hydrogen transport (GO:0006818)2.77221263
80positive regulation of protein homodimerization activity (GO:0090073)2.76827514
81centriole replication (GO:0007099)2.75393843
82negative regulation of mast cell activation (GO:0033004)2.72086195
83regulation of cilium movement (GO:0003352)2.68875291
84somite development (GO:0061053)2.68270627
85positive regulation of organelle assembly (GO:1902117)2.68183199
86phosphate ion transport (GO:0006817)2.68174546
87piRNA metabolic process (GO:0034587)2.68025453
88nucleobase catabolic process (GO:0046113)2.65924118
89GPI anchor metabolic process (GO:0006505)2.64087873
90ribonucleoside triphosphate biosynthetic process (GO:0009201)2.62885494
91axon ensheathment in central nervous system (GO:0032291)2.59695815
92central nervous system myelination (GO:0022010)2.59695815
93protein targeting (GO:0006605)2.57002542
94somite rostral/caudal axis specification (GO:0032525)2.56774429
95kynurenine metabolic process (GO:0070189)2.56369570
96rRNA processing (GO:0006364)2.49505495
97negative regulation of synaptic transmission, GABAergic (GO:0032229)2.49439533
98dentate gyrus development (GO:0021542)2.49236766
99tryptophan metabolic process (GO:0006568)2.47567657
100DNA deamination (GO:0045006)2.47374233

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.06606933
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.53925042
3GABP_17652178_ChIP-ChIP_JURKAT_Human2.48275709
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.45536043
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.34200240
6ZNF274_21170338_ChIP-Seq_K562_Hela2.33691822
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.28763921
8VDR_22108803_ChIP-Seq_LS180_Human2.25485476
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.11906318
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.06663313
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.06443558
12TAF15_26573619_Chip-Seq_HEK293_Human1.95998218
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82776398
14BMI1_23680149_ChIP-Seq_NPCS_Mouse1.81391778
15EWS_26573619_Chip-Seq_HEK293_Human1.80398039
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.78996053
17EZH2_27304074_Chip-Seq_ESCs_Mouse1.76508673
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.74904467
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72813372
20GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.71969647
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.71943348
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71576320
23P300_19829295_ChIP-Seq_ESCs_Human1.71303743
24MYC_18940864_ChIP-ChIP_HL60_Human1.70979884
25PCGF2_27294783_Chip-Seq_NPCs_Mouse1.69306808
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65682662
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.64568326
28IRF1_19129219_ChIP-ChIP_H3396_Human1.58881927
29TP53_22573176_ChIP-Seq_HFKS_Human1.57550616
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52406068
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.51116883
32FUS_26573619_Chip-Seq_HEK293_Human1.50216459
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45852188
34REST_21632747_ChIP-Seq_MESCs_Mouse1.44767697
35FOXA1_25329375_ChIP-Seq_VCAP_Human1.41876307
36FOXA1_27270436_Chip-Seq_PROSTATE_Human1.41876307
37CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.41784481
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39990394
39MYC_18555785_ChIP-Seq_MESCs_Mouse1.39871795
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.38700452
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.35259306
42GATA3_21878914_ChIP-Seq_MCF-7_Human1.33494402
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32664518
44RNF2_27304074_Chip-Seq_NSC_Mouse1.31831159
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.30448026
46NCOR_22424771_ChIP-Seq_293T_Human1.28146108
47NANOG_19829295_ChIP-Seq_ESCs_Human1.27652677
48SOX2_19829295_ChIP-Seq_ESCs_Human1.27652677
49RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.26578070
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25894164
51ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25868901
52TTF2_22483619_ChIP-Seq_HELA_Human1.23895460
53REST_18959480_ChIP-ChIP_MESCs_Mouse1.23587539
54TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23311029
55ERA_21632823_ChIP-Seq_H3396_Human1.21324471
56JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.21239532
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20925994
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19203680
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19203680
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.18928367
61KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18450361
62SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18168745
63NANOG_20526341_ChIP-Seq_ESCs_Human1.16914702
64ERG_20517297_ChIP-Seq_VCAP_Human1.16647603
65VDR_23849224_ChIP-Seq_CD4+_Human1.15658669
66ELK1_19687146_ChIP-ChIP_HELA_Human1.13042063
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12391116
68CBP_20019798_ChIP-Seq_JUKART_Human1.12391116
69TDRD3_21172665_ChIP-Seq_MCF-7_Human1.10446447
70JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10066122
71GBX2_23144817_ChIP-Seq_PC3_Human1.07774223
72FOXH1_21741376_ChIP-Seq_EPCs_Human1.06667215
73POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06592555
74HTT_18923047_ChIP-ChIP_STHdh_Human1.06367430
75SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04804005
76AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04698724
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04527002
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03901084
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03879539
80BCAT_22108803_ChIP-Seq_LS180_Human1.03806113
81RUNX2_22187159_ChIP-Seq_PCA_Human1.03761672
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02551692
83ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02399464
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01582735
85SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.00169522
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99713182
87RNF2_18974828_ChIP-Seq_MESCs_Mouse0.99432687
88EZH2_18974828_ChIP-Seq_MESCs_Mouse0.99432687
89SMAD3_21741376_ChIP-Seq_ESCs_Human0.98864964
90MYC_19829295_ChIP-Seq_ESCs_Human0.98786471
91SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98432455
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98080196
93FOXP3_21729870_ChIP-Seq_TREG_Human0.97937686
94SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.97795875
95ER_23166858_ChIP-Seq_MCF-7_Human0.97103760
96PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96899797
97SMAD3_21741376_ChIP-Seq_EPCs_Human0.95247356
98AR_25329375_ChIP-Seq_VCAP_Human0.94955671
99SOX2_16153702_ChIP-ChIP_HESCs_Human0.94760857
100RNF2_27304074_Chip-Seq_ESCs_Mouse0.94663861

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.17101656
2MP0006292_abnormal_olfactory_placode4.70872518
3MP0003787_abnormal_imprinting3.41586704
4MP0008877_abnormal_DNA_methylation3.23903655
5MP0003122_maternal_imprinting2.89470201
6MP0008789_abnormal_olfactory_epithelium2.48048054
7MP0002102_abnormal_ear_morphology2.41223358
8MP0004142_abnormal_muscle_tone2.26879929
9MP0006072_abnormal_retinal_apoptosis2.21536393
10MP0008872_abnormal_physiological_respon2.16753893
11MP0005394_taste/olfaction_phenotype2.07499684
12MP0005499_abnormal_olfactory_system2.07499684
13MP0001835_abnormal_antigen_presentation1.98464861
14MP0005551_abnormal_eye_electrophysiolog1.96708110
15MP0003121_genomic_imprinting1.95205829
16MP0005423_abnormal_somatic_nervous1.87406542
17MP0003878_abnormal_ear_physiology1.81622658
18MP0005377_hearing/vestibular/ear_phenot1.81622658
19MP0006276_abnormal_autonomic_nervous1.79353437
20MP0001293_anophthalmia1.78179300
21MP0001986_abnormal_taste_sensitivity1.71493677
22MP0002163_abnormal_gland_morphology1.69588741
23MP0001529_abnormal_vocalization1.69572740
24MP0003879_abnormal_hair_cell1.68900788
25MP0001485_abnormal_pinna_reflex1.64292517
26MP0002837_dystrophic_cardiac_calcinosis1.63467957
27MP0001984_abnormal_olfaction1.62046006
28MP0004145_abnormal_muscle_electrophysio1.56178243
29MP0002234_abnormal_pharynx_morphology1.51236813
30MP0002938_white_spotting1.44431908
31MP0004885_abnormal_endolymph1.40406941
32MP0009745_abnormal_behavioral_response1.36914944
33MP0001970_abnormal_pain_threshold1.30978722
34MP0002557_abnormal_social/conspecific_i1.30059400
35MP0004147_increased_porphyrin_level1.27027641
36MP0000778_abnormal_nervous_system1.25864564
37MP0005253_abnormal_eye_physiology1.23840224
38MP0001348_abnormal_lacrimal_gland1.23593035
39MP0002272_abnormal_nervous_system1.22316893
40MP0009046_muscle_twitch1.22023916
41MP0002572_abnormal_emotion/affect_behav1.21731385
42MP0005084_abnormal_gallbladder_morpholo1.21571445
43MP0000631_abnormal_neuroendocrine_gland1.21063559
44MP0001968_abnormal_touch/_nociception1.20755203
45MP0003646_muscle_fatigue1.18578755
46MP0002653_abnormal_ependyma_morphology1.17508446
47MP0001905_abnormal_dopamine_level1.17439785
48MP0004133_heterotaxia1.17339387
49MP0008875_abnormal_xenobiotic_pharmacok1.16447329
50MP0005195_abnormal_posterior_eye1.16313002
51MP0003195_calcinosis1.15881995
52MP0005389_reproductive_system_phenotype1.15785656
53MP0000049_abnormal_middle_ear1.15393240
54MP0002876_abnormal_thyroid_physiology1.13736055
55MP0001919_abnormal_reproductive_system1.11953335
56MP0002184_abnormal_innervation1.10067435
57MP0000427_abnormal_hair_cycle1.08711180
58MP0003880_abnormal_central_pattern1.05503471
59MP0002063_abnormal_learning/memory/cond1.04617123
60MP0003635_abnormal_synaptic_transmissio1.03866932
61MP0003890_abnormal_embryonic-extraembry1.02924037
62MP0005379_endocrine/exocrine_gland_phen1.02654945
63MP0001486_abnormal_startle_reflex1.02251040
64MP0000566_synostosis1.02082960
65MP0001963_abnormal_hearing_physiology1.01928541
66MP0001440_abnormal_grooming_behavior1.01168952
67MP0002909_abnormal_adrenal_gland1.00913390
68MP0000026_abnormal_inner_ear1.00189130
69MP0002064_seizures0.99794412
70MP0002733_abnormal_thermal_nociception0.99603913
71MP0002734_abnormal_mechanical_nocicepti0.98810029
72MP0002735_abnormal_chemical_nociception0.95644089
73MP0002752_abnormal_somatic_nervous0.95093076
74MP0002277_abnormal_respiratory_mucosa0.93666581
75MP0002638_abnormal_pupillary_reflex0.93155320
76MP0003011_delayed_dark_adaptation0.89767467
77MP0003283_abnormal_digestive_organ0.89614771
78MP0002693_abnormal_pancreas_physiology0.87605588
79MP0005646_abnormal_pituitary_gland0.87085895
80MP0002736_abnormal_nociception_after0.86704678
81MP0001502_abnormal_circadian_rhythm0.86275459
82MP0000372_irregular_coat_pigmentation0.85921028
83MP0002095_abnormal_skin_pigmentation0.83934824
84MP0005671_abnormal_response_to0.83496203
85MP0003186_abnormal_redox_activity0.82694263
86MP0000955_abnormal_spinal_cord0.82420338
87MP0002067_abnormal_sensory_capabilities0.82006768
88MP0000230_abnormal_systemic_arterial0.81774580
89MP0004742_abnormal_vestibular_system0.81529867
90MP0010030_abnormal_orbit_morphology0.78916918
91MP0005645_abnormal_hypothalamus_physiol0.78649826
92MP0004019_abnormal_vitamin_homeostasis0.73957744
93MP0010386_abnormal_urinary_bladder0.73226700
94MP0002160_abnormal_reproductive_system0.71676305
95MP0002229_neurodegeneration0.71048325
96MP0005448_abnormal_energy_balance0.70805602
97MP0008995_early_reproductive_senescence0.70780868
98MP0005171_absent_coat_pigmentation0.70054231
99MP0001286_abnormal_eye_development0.69958262
100MP0005391_vision/eye_phenotype0.68408983

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.26201113
2Acute necrotizing encephalopathy (HP:0006965)4.30349503
3Colon cancer (HP:0003003)3.76509881
4Abnormality of cells of the erythroid lineage (HP:0012130)3.74572627
5Macrocytic anemia (HP:0001972)3.65801622
6Abnormal mitochondria in muscle tissue (HP:0008316)3.60425391
7Mitochondrial inheritance (HP:0001427)3.57526666
8Acute encephalopathy (HP:0006846)3.54527602
9Stenosis of the external auditory canal (HP:0000402)3.50242760
10Progressive macrocephaly (HP:0004481)3.47393192
11Increased hepatocellular lipid droplets (HP:0006565)3.41945107
12Lipid accumulation in hepatocytes (HP:0006561)3.38887346
13Molar tooth sign on MRI (HP:0002419)3.30399687
14Abnormality of midbrain morphology (HP:0002418)3.30399687
15Absent rod-and cone-mediated responses on ERG (HP:0007688)3.29327545
16Increased CSF lactate (HP:0002490)3.23746490
17Pancreatic fibrosis (HP:0100732)3.14989646
18Abolished electroretinogram (ERG) (HP:0000550)3.10400883
19Pallor (HP:0000980)3.04479061
20Type II lissencephaly (HP:0007260)2.99470054
21Septo-optic dysplasia (HP:0100842)2.97449786
22Cerebral edema (HP:0002181)2.94795951
233-Methylglutaconic aciduria (HP:0003535)2.91354370
24Pancreatic cysts (HP:0001737)2.86144677
25Optic disc pallor (HP:0000543)2.84821396
26Renal Fanconi syndrome (HP:0001994)2.83658710
27Abnormal rod and cone electroretinograms (HP:0008323)2.79782244
28Abnormal hemoglobin (HP:0011902)2.71784229
29Nephronophthisis (HP:0000090)2.66454512
30Abnormality of the labia minora (HP:0012880)2.65791904
31Increased intramyocellular lipid droplets (HP:0012240)2.63840343
32Attenuation of retinal blood vessels (HP:0007843)2.62928715
33Supernumerary spleens (HP:0009799)2.62602300
34Growth hormone deficiency (HP:0000824)2.60248538
35Exertional dyspnea (HP:0002875)2.59188691
36Abnormal number of erythroid precursors (HP:0012131)2.58759342
37Cerebellar dysplasia (HP:0007033)2.56017238
38Medial flaring of the eyebrow (HP:0010747)2.52601404
39Optic nerve hypoplasia (HP:0000609)2.43276797
40Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.40647978
41Decreased activity of mitochondrial respiratory chain (HP:0008972)2.40647978
42Hepatocellular necrosis (HP:0001404)2.40252958
43Stomatitis (HP:0010280)2.37265097
44Abnormal drinking behavior (HP:0030082)2.35516407
45Polydipsia (HP:0001959)2.35516407
46Methylmalonic acidemia (HP:0002912)2.32128046
47Rib fusion (HP:0000902)2.30790421
48True hermaphroditism (HP:0010459)2.30185209
49Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.29564723
50Asplenia (HP:0001746)2.29017690
51Increased muscle lipid content (HP:0009058)2.28182397
52Aplasia/Hypoplasia of the spleen (HP:0010451)2.27774871
53Agitation (HP:0000713)2.23951644
54Dynein arm defect of respiratory motile cilia (HP:0012255)2.18278075
55Absent/shortened dynein arms (HP:0200106)2.18278075
56Absent thumb (HP:0009777)2.17992781
57Gait imbalance (HP:0002141)2.17247649
58Pendular nystagmus (HP:0012043)2.14959634
59Diastasis recti (HP:0001540)2.14206391
60Congenital stationary night blindness (HP:0007642)2.11989456
61Abnormality of the renal medulla (HP:0100957)2.11791272
62Myokymia (HP:0002411)2.10524426
63Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.08606766
64Hypoplasia of the ulna (HP:0003022)2.08586350
65Bony spicule pigmentary retinopathy (HP:0007737)2.08348133
66Elevated erythrocyte sedimentation rate (HP:0003565)2.07928409
67Hepatic necrosis (HP:0002605)2.06260201
68Congenital primary aphakia (HP:0007707)2.04094348
69Degeneration of the lateral corticospinal tracts (HP:0002314)2.02863914
70Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.02863914
71Abnormality of renal resorption (HP:0011038)2.01459757
72Sclerocornea (HP:0000647)2.01211957
73Polyphagia (HP:0002591)2.00110488
74Leukodystrophy (HP:0002415)1.99919725
75Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.99740013
76Glycosuria (HP:0003076)1.99558380
77Abnormality of urine glucose concentration (HP:0011016)1.99558380
78Cystic liver disease (HP:0006706)1.99306912
79Enlarged kidneys (HP:0000105)1.96836047
80Increased serum lactate (HP:0002151)1.95229110
81Abnormal respiratory motile cilium morphology (HP:0005938)1.92253215
82Abnormal respiratory epithelium morphology (HP:0012253)1.92253215
83Concave nail (HP:0001598)1.91799776
84Abnormal ciliary motility (HP:0012262)1.90251379
85Maternal diabetes (HP:0009800)1.87833412
86Depressed nasal ridge (HP:0000457)1.85067855
87Poor coordination (HP:0002370)1.83733429
88Decreased central vision (HP:0007663)1.83550955
89Abnormal respiratory motile cilium physiology (HP:0012261)1.81716929
90Partial agenesis of the corpus callosum (HP:0001338)1.80701622
91Male pseudohermaphroditism (HP:0000037)1.78179988
92Absent septum pellucidum (HP:0001331)1.77734133
93Congenital malformation of the right heart (HP:0011723)1.76677354
94Double outlet right ventricle (HP:0001719)1.76677354
95Anencephaly (HP:0002323)1.75729476
96Median cleft lip (HP:0000161)1.74271721
97Congenital, generalized hypertrichosis (HP:0004540)1.73644851
98Adrenal hypoplasia (HP:0000835)1.72245090
99Genetic anticipation (HP:0003743)1.72137428
100Hyperphosphaturia (HP:0003109)1.72105074

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K123.37376755
2TLK13.09845328
3WNK43.04790362
4ADRBK22.99085598
5GRK12.76419328
6WNK32.71217044
7CDK192.01160911
8MAP4K21.99412190
9DYRK21.92481634
10VRK21.84360145
11MKNK21.83266001
12BMPR21.79873511
13BCKDK1.75448867
14ZAK1.66908660
15TAOK31.61895564
16FRK1.61775480
17EPHA41.59397475
18EPHB21.56278458
19PINK11.55868128
20STK161.55631941
21WNK11.55061195
22BMPR1B1.40408128
23NME11.39831397
24MAP3K111.37787218
25MAP3K41.36584968
26PASK1.26799130
27ADRBK11.26268332
28DAPK31.23443570
29NUAK11.22758844
30PIK3CA1.22621488
31STK391.19365942
32PLK41.19081294
33LRRK21.17291340
34CASK1.09574156
35TRIM281.04346111
36MYLK1.04206819
37INSRR0.99961852
38PHKG20.99208848
39PHKG10.99208848
40PRKCG0.98486920
41MKNK10.97828904
42CAMKK20.94237072
43MAPK130.93993924
44TNIK0.93198082
45GRK70.88996182
46CSNK1G20.85832271
47PAK30.83371505
48TEC0.81315660
49OXSR10.80052231
50STK110.79761042
51TAF10.79733108
52AURKB0.78930119
53DAPK20.78492723
54TGFBR10.77833139
55VRK10.76977352
56CAMK1D0.76870094
57CAMK10.75739429
58OBSCN0.74714755
59CSNK1G30.74523351
60ITK0.73424304
61BUB10.72029233
62NEK20.71660426
63EIF2AK10.66784662
64NTRK20.65559698
65DAPK10.65352394
66PRKACA0.64832115
67CSNK2A20.64567063
68ATR0.64369223
69MUSK0.62589978
70PLK20.62367430
71IKBKB0.61611909
72MAP4K10.61068570
73DYRK1B0.58326514
74PLK10.56502152
75PRKCQ0.55760220
76CHEK20.55511278
77FES0.54901236
78ILK0.53895565
79CSNK1G10.53246152
80MINK10.52277674
81PLK30.52068391
82PBK0.49933912
83TXK0.49854817
84PRKCZ0.49525908
85PRKCE0.49435061
86PRKCI0.49415838
87CSNK1A1L0.48873238
88CDK30.48197959
89CSNK1E0.47972757
90MAP2K70.47544284
91PIM10.47367673
92PRKCA0.47270227
93CAMK2A0.47156106
94CAMKK10.45877575
95GRK50.43355393
96ERBB30.43315780
97RPS6KA60.41486832
98PIK3CG0.40711412
99SCYL20.39553025
100TIE10.38838576

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.36790652
2Oxidative phosphorylation_Homo sapiens_hsa001904.27801521
3Asthma_Homo sapiens_hsa053103.76458440
4Parkinsons disease_Homo sapiens_hsa050123.29770170
5RNA polymerase_Homo sapiens_hsa030202.71588301
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.49940098
7Cardiac muscle contraction_Homo sapiens_hsa042602.49551092
8Alzheimers disease_Homo sapiens_hsa050102.43939139
9Allograft rejection_Homo sapiens_hsa053302.42006714
10Protein export_Homo sapiens_hsa030602.38787210
11Autoimmune thyroid disease_Homo sapiens_hsa053202.35388549
12Huntingtons disease_Homo sapiens_hsa050162.28409420
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.19505997
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.12139764
15Phototransduction_Homo sapiens_hsa047441.88680126
16Vitamin B6 metabolism_Homo sapiens_hsa007501.86286998
17Type I diabetes mellitus_Homo sapiens_hsa049401.67611941
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.66416575
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.61491807
20Graft-versus-host disease_Homo sapiens_hsa053321.53755186
21Proteasome_Homo sapiens_hsa030501.51728359
22RNA degradation_Homo sapiens_hsa030181.50755678
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46910823
24Homologous recombination_Homo sapiens_hsa034401.42041895
25Nicotine addiction_Homo sapiens_hsa050331.20603608
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20301897
27Linoleic acid metabolism_Homo sapiens_hsa005911.18709233
28Collecting duct acid secretion_Homo sapiens_hsa049661.12657133
29Mismatch repair_Homo sapiens_hsa034301.08829355
30Nitrogen metabolism_Homo sapiens_hsa009101.08745372
31Folate biosynthesis_Homo sapiens_hsa007901.03727029
32Rheumatoid arthritis_Homo sapiens_hsa053231.02129271
33Pyrimidine metabolism_Homo sapiens_hsa002401.01615914
34Basal transcription factors_Homo sapiens_hsa030221.00160904
35Sulfur relay system_Homo sapiens_hsa041220.98252393
36Tryptophan metabolism_Homo sapiens_hsa003800.97158961
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96021938
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93023021
39Chemical carcinogenesis_Homo sapiens_hsa052040.92235400
40Fat digestion and absorption_Homo sapiens_hsa049750.91736780
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90303656
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89737642
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88252528
44Butanoate metabolism_Homo sapiens_hsa006500.81237183
45Nucleotide excision repair_Homo sapiens_hsa034200.81194770
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78500134
47Purine metabolism_Homo sapiens_hsa002300.78128220
48Fanconi anemia pathway_Homo sapiens_hsa034600.74006767
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73155191
50Peroxisome_Homo sapiens_hsa041460.72867480
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72675706
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.71423527
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71086448
54One carbon pool by folate_Homo sapiens_hsa006700.68803212
55beta-Alanine metabolism_Homo sapiens_hsa004100.67486256
56Primary immunodeficiency_Homo sapiens_hsa053400.67121066
57Propanoate metabolism_Homo sapiens_hsa006400.66485199
58Olfactory transduction_Homo sapiens_hsa047400.64963536
59Metabolic pathways_Homo sapiens_hsa011000.63663364
60Caffeine metabolism_Homo sapiens_hsa002320.63537545
61Taste transduction_Homo sapiens_hsa047420.62188046
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.61494802
63Insulin secretion_Homo sapiens_hsa049110.60059433
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.55201923
65Retinol metabolism_Homo sapiens_hsa008300.55141892
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51566969
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50682200
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50269304
69Circadian entrainment_Homo sapiens_hsa047130.49674811
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49120062
71Glutathione metabolism_Homo sapiens_hsa004800.48615417
72Morphine addiction_Homo sapiens_hsa050320.48412616
73Arachidonic acid metabolism_Homo sapiens_hsa005900.47599245
74Glutamatergic synapse_Homo sapiens_hsa047240.46006888
75DNA replication_Homo sapiens_hsa030300.43266452
76Hedgehog signaling pathway_Homo sapiens_hsa043400.42501261
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40941331
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40240498
79Serotonergic synapse_Homo sapiens_hsa047260.39079994
80Base excision repair_Homo sapiens_hsa034100.38456106
81Fatty acid degradation_Homo sapiens_hsa000710.37215988
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36225597
83Systemic lupus erythematosus_Homo sapiens_hsa053220.36024953
84GABAergic synapse_Homo sapiens_hsa047270.35938506
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35689337
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35607943
87Ether lipid metabolism_Homo sapiens_hsa005650.34136144
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33263153
89Glycerolipid metabolism_Homo sapiens_hsa005610.31915317
90Salivary secretion_Homo sapiens_hsa049700.30056882
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30008022
92Starch and sucrose metabolism_Homo sapiens_hsa005000.29536336
93Hematopoietic cell lineage_Homo sapiens_hsa046400.28460817
94RNA transport_Homo sapiens_hsa030130.28075386
95Circadian rhythm_Homo sapiens_hsa047100.27474312
96Histidine metabolism_Homo sapiens_hsa003400.27225377
97Basal cell carcinoma_Homo sapiens_hsa052170.26809769
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.26534245
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23398393
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22754234

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