RPL5P15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1water-soluble vitamin biosynthetic process (GO:0042364)5.33046706
2ribosomal large subunit biogenesis (GO:0042273)4.42400153
3behavioral response to nicotine (GO:0035095)4.30970757
4maturation of SSU-rRNA (GO:0030490)4.25874399
5detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.15512783
6protein neddylation (GO:0045116)4.14417029
7regulation of isotype switching to IgG isotypes (GO:0048302)4.13891319
8positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.99428261
9maturation of 5.8S rRNA (GO:0000460)3.87605470
10ATP synthesis coupled proton transport (GO:0015986)3.87214002
11energy coupled proton transport, down electrochemical gradient (GO:0015985)3.87214002
12DNA deamination (GO:0045006)3.81574311
13regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.81321405
14ribosomal small subunit assembly (GO:0000028)3.74697082
15cellular ketone body metabolic process (GO:0046950)3.72991362
16viral transcription (GO:0019083)3.72091068
17translational termination (GO:0006415)3.69611278
18transcription elongation from RNA polymerase III promoter (GO:0006385)3.65405836
19termination of RNA polymerase III transcription (GO:0006386)3.65405836
20mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.60050136
21cullin deneddylation (GO:0010388)3.57626186
22GTP biosynthetic process (GO:0006183)3.56561206
23establishment of protein localization to mitochondrial membrane (GO:0090151)3.55963263
24nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.48790501
25ketone body metabolic process (GO:1902224)3.43239216
26exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.41151707
27kidney morphogenesis (GO:0060993)3.36614674
28ubiquinone metabolic process (GO:0006743)3.36613848
29response to pheromone (GO:0019236)3.36530232
30regulation of immunoglobulin secretion (GO:0051023)3.30286873
31translational elongation (GO:0006414)3.28566481
32SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.27193506
33mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.27162336
34protein deneddylation (GO:0000338)3.26587573
35protein-cofactor linkage (GO:0018065)3.23292903
36cotranslational protein targeting to membrane (GO:0006613)3.22872763
37protein targeting to ER (GO:0045047)3.22383569
38short-chain fatty acid metabolic process (GO:0046459)3.21951441
39chaperone-mediated protein transport (GO:0072321)3.21609684
40protein complex biogenesis (GO:0070271)3.20103857
41mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.14908061
42mitochondrial respiratory chain complex I assembly (GO:0032981)3.14908061
43NADH dehydrogenase complex assembly (GO:0010257)3.14908061
44establishment of protein localization to endoplasmic reticulum (GO:0072599)3.09040172
45protein localization to endoplasmic reticulum (GO:0070972)3.07898604
46cellular response to ATP (GO:0071318)3.06929748
47pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.03802437
48electron transport chain (GO:0022900)3.03079515
49ribosomal small subunit biogenesis (GO:0042274)2.99082862
50respiratory electron transport chain (GO:0022904)2.96641764
51UTP biosynthetic process (GO:0006228)2.93613956
52tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.91111580
53RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.91111580
54positive regulation of isotype switching (GO:0045830)2.89787725
55mitochondrial respiratory chain complex assembly (GO:0033108)2.89344519
56translation (GO:0006412)2.89311136
57tRNA processing (GO:0008033)2.89302257
58peptidyl-histidine modification (GO:0018202)2.84448875
59UTP metabolic process (GO:0046051)2.84397122
60positive regulation of DNA recombination (GO:0045911)2.84393854
61translational initiation (GO:0006413)2.78677692
62DNA catabolic process, exonucleolytic (GO:0000738)2.71736147
63viral life cycle (GO:0019058)2.71655249
64regulation of action potential (GO:0098900)2.70393258
65negative regulation of telomere maintenance (GO:0032205)2.69244464
66rRNA modification (GO:0000154)2.68803655
67cellular component biogenesis (GO:0044085)2.68667016
68rRNA processing (GO:0006364)2.67450085
69chromatin remodeling at centromere (GO:0031055)2.66279877
70regulation of cellular amino acid metabolic process (GO:0006521)2.64333237
71rRNA metabolic process (GO:0016072)2.64191330
72DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.63620586
73ribonucleoprotein complex biogenesis (GO:0022613)2.60548217
74fucose catabolic process (GO:0019317)2.60460471
75L-fucose metabolic process (GO:0042354)2.60460471
76L-fucose catabolic process (GO:0042355)2.60460471
77cellular protein complex disassembly (GO:0043624)2.60293628
78nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.59577967
79RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.59287977
80signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.58488747
81signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.58488747
82signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.58488747
83tRNA metabolic process (GO:0006399)2.56953240
84branched-chain amino acid catabolic process (GO:0009083)2.55457438
85indolalkylamine metabolic process (GO:0006586)2.53598644
86adaptation of signaling pathway (GO:0023058)2.53128443
87CTP metabolic process (GO:0046036)2.51939851
88CTP biosynthetic process (GO:0006241)2.51939851
89intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.51934162
90signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.51934162
91vitamin biosynthetic process (GO:0009110)2.51823497
92ubiquinone biosynthetic process (GO:0006744)2.51497828
93purine nucleoside triphosphate biosynthetic process (GO:0009145)2.51303285
94nonmotile primary cilium assembly (GO:0035058)2.49543961
95purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.49538108
96piRNA metabolic process (GO:0034587)2.49253093
97termination of RNA polymerase I transcription (GO:0006363)2.47136753
98base-excision repair, AP site formation (GO:0006285)2.46547341
99pseudouridine synthesis (GO:0001522)2.45581385
100isoprenoid biosynthetic process (GO:0008299)2.45035787

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.05401090
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.78087808
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.68618622
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.49062854
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.11588104
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.01529031
7VDR_22108803_ChIP-Seq_LS180_Human2.96825142
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.94362459
9ZNF274_21170338_ChIP-Seq_K562_Hela2.83375742
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.78625367
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.53983878
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.42508559
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.41425280
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.34235973
15PCGF2_27294783_Chip-Seq_NPCs_Mouse2.14276647
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14274786
17VDR_23849224_ChIP-Seq_CD4+_Human2.14269752
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.08983521
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.04345106
20IGF1R_20145208_ChIP-Seq_DFB_Human1.96907631
21EWS_26573619_Chip-Seq_HEK293_Human1.90194331
22FOXP3_21729870_ChIP-Seq_TREG_Human1.76432989
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.75722200
24MYC_18940864_ChIP-ChIP_HL60_Human1.72962916
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70812211
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.67351818
27FUS_26573619_Chip-Seq_HEK293_Human1.63214825
28ELK1_19687146_ChIP-ChIP_HELA_Human1.62387830
29TP53_22573176_ChIP-Seq_HFKS_Human1.58115740
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.54326553
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.53225261
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48547281
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44909657
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44562662
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.43617015
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.42234712
37TTF2_22483619_ChIP-Seq_HELA_Human1.41400656
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37987350
39NFE2_27457419_Chip-Seq_LIVER_Mouse1.35140148
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35117769
41GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.34245122
42ER_23166858_ChIP-Seq_MCF-7_Human1.33920915
43MYC_18555785_ChIP-Seq_MESCs_Mouse1.32876334
44P300_19829295_ChIP-Seq_ESCs_Human1.31610743
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26563139
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.22462430
47REST_21632747_ChIP-Seq_MESCs_Mouse1.22407125
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.21963915
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21756666
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21169605
51AUTS2_25519132_ChIP-Seq_293T-REX_Human1.21036726
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.19369833
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18926714
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18715969
55MYC_18358816_ChIP-ChIP_MESCs_Mouse1.17338374
56GATA3_21878914_ChIP-Seq_MCF-7_Human1.14733658
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13767947
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.13767947
59TAF2_19829295_ChIP-Seq_ESCs_Human1.08437736
60NANOG_19829295_ChIP-Seq_ESCs_Human1.08380007
61SOX2_19829295_ChIP-Seq_ESCs_Human1.08380007
62NCOR_22424771_ChIP-Seq_293T_Human1.07358104
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06060115
64BCAT_22108803_ChIP-Seq_LS180_Human1.05741742
65LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05532358
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.05354448
67FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05191643
68GABP_19822575_ChIP-Seq_HepG2_Human1.04750550
69KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03877212
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02747871
71TAF15_26573619_Chip-Seq_HEK293_Human1.02344591
72GBX2_23144817_ChIP-Seq_PC3_Human1.02136958
73AR_20517297_ChIP-Seq_VCAP_Human0.99266288
74CBP_20019798_ChIP-Seq_JUKART_Human0.98894241
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98894241
76P53_22387025_ChIP-Seq_ESCs_Mouse0.98835060
77CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98583971
78ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98281728
79CRX_20693478_ChIP-Seq_RETINA_Mouse0.98173291
80FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97249722
81LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96131929
82IRF1_19129219_ChIP-ChIP_H3396_Human0.96059097
83TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95780506
84RNF2_27304074_Chip-Seq_NSC_Mouse0.94704270
85MYC_19829295_ChIP-Seq_ESCs_Human0.94448873
86ERA_21632823_ChIP-Seq_H3396_Human0.93311973
87NANOG_20526341_ChIP-Seq_ESCs_Human0.92147232
88PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.90411474
89POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89770618
90SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89325238
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88913469
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88494589
93STAT3_18555785_Chip-Seq_ESCs_Mouse0.88357507
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87044467
95P300_18555785_Chip-Seq_ESCs_Mouse0.86599345
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86359580
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86359580
98EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.86043007
99TCF4_22108803_ChIP-Seq_LS180_Human0.85646513
100EZH2_27304074_Chip-Seq_ESCs_Mouse0.85489608

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology4.28401348
2MP0009379_abnormal_foot_pigmentation4.19157736
3MP0006292_abnormal_olfactory_placode3.82291112
4MP0005646_abnormal_pituitary_gland2.68431014
5MP0005645_abnormal_hypothalamus_physiol2.58046137
6MP0003787_abnormal_imprinting2.54950880
7MP0004147_increased_porphyrin_level2.50001274
8MP0004885_abnormal_endolymph2.40172241
9MP0008875_abnormal_xenobiotic_pharmacok2.30004354
10MP0008877_abnormal_DNA_methylation2.27235777
11MP0001188_hyperpigmentation2.25900660
12MP0001968_abnormal_touch/_nociception2.16714205
13MP0008872_abnormal_physiological_respon2.12986889
14MP0003011_delayed_dark_adaptation2.09055875
15MP0002736_abnormal_nociception_after1.90061442
16MP0004142_abnormal_muscle_tone1.82874841
17MP0005551_abnormal_eye_electrophysiolog1.81953629
18MP0003878_abnormal_ear_physiology1.77277051
19MP0005377_hearing/vestibular/ear_phenot1.77277051
20MP0008789_abnormal_olfactory_epithelium1.72010438
21MP0005084_abnormal_gallbladder_morpholo1.70931173
22MP0002272_abnormal_nervous_system1.69219596
23MP0006276_abnormal_autonomic_nervous1.68522867
24MP0002876_abnormal_thyroid_physiology1.67760325
25MP0003122_maternal_imprinting1.66949817
26MP0003646_muscle_fatigue1.66269170
27MP0002837_dystrophic_cardiac_calcinosis1.59547959
28MP0000372_irregular_coat_pigmentation1.57524743
29MP0008058_abnormal_DNA_repair1.56908042
30MP0004145_abnormal_muscle_electrophysio1.52897550
31MP0001986_abnormal_taste_sensitivity1.49771573
32MP0001984_abnormal_olfaction1.42477589
33MP0001529_abnormal_vocalization1.40321789
34MP0002733_abnormal_thermal_nociception1.37957164
35MP0006072_abnormal_retinal_apoptosis1.36848284
36MP0002938_white_spotting1.34140901
37MP0002638_abnormal_pupillary_reflex1.30000550
38MP0002163_abnormal_gland_morphology1.29951008
39MP0003880_abnormal_central_pattern1.29658653
40MP0008775_abnormal_heart_ventricle1.29546851
41MP0002160_abnormal_reproductive_system1.28781239
42MP0001485_abnormal_pinna_reflex1.26659678
43MP0003121_genomic_imprinting1.22743031
44MP0002277_abnormal_respiratory_mucosa1.22305112
45MP0005394_taste/olfaction_phenotype1.21975329
46MP0005499_abnormal_olfactory_system1.21975329
47MP0005410_abnormal_fertilization1.21352404
48MP0002693_abnormal_pancreas_physiology1.20235478
49MP0002184_abnormal_innervation1.18927693
50MP0005389_reproductive_system_phenotype1.18918640
51MP0001293_anophthalmia1.18903401
52MP0000631_abnormal_neuroendocrine_gland1.18675984
53MP0001905_abnormal_dopamine_level1.16340636
54MP0001970_abnormal_pain_threshold1.15484580
55MP0003786_premature_aging1.11584417
56MP0003879_abnormal_hair_cell1.11318442
57MP0002095_abnormal_skin_pigmentation1.10833597
58MP0009333_abnormal_splenocyte_physiolog1.07060188
59MP0009745_abnormal_behavioral_response1.04426457
60MP0003186_abnormal_redox_activity1.03770265
61MP0001919_abnormal_reproductive_system1.03523228
62MP0002653_abnormal_ependyma_morphology1.03401406
63MP0002557_abnormal_social/conspecific_i1.01641240
64MP0009046_muscle_twitch0.97793255
65MP0002735_abnormal_chemical_nociception0.97744789
66MP0002138_abnormal_hepatobiliary_system0.96904960
67MP0000647_abnormal_sebaceous_gland0.96625459
68MP0005636_abnormal_mineral_homeostasis0.96315782
69MP0003718_maternal_effect0.96197894
70MP0009785_altered_susceptibility_to0.92228709
71MP0000955_abnormal_spinal_cord0.90968676
72MP0005195_abnormal_posterior_eye0.89381213
73MP0000778_abnormal_nervous_system0.87740418
74MP0006036_abnormal_mitochondrial_physio0.86977421
75MP0004742_abnormal_vestibular_system0.85930560
76MP0005379_endocrine/exocrine_gland_phen0.85393578
77MP0002572_abnormal_emotion/affect_behav0.84947618
78MP0005187_abnormal_penis_morphology0.84743850
79MP0000026_abnormal_inner_ear0.83677499
80MP0002752_abnormal_somatic_nervous0.83519521
81MP0000015_abnormal_ear_pigmentation0.82405129
82MP0001486_abnormal_startle_reflex0.81618375
83MP0001835_abnormal_antigen_presentation0.80590341
84MP0008057_abnormal_DNA_replication0.80044991
85MP0005671_abnormal_response_to0.79912909
86MP0002734_abnormal_mechanical_nocicepti0.79020383
87MP0005075_abnormal_melanosome_morpholog0.78400856
88MP0005253_abnormal_eye_physiology0.78279731
89MP0001963_abnormal_hearing_physiology0.77086429
90MP0010386_abnormal_urinary_bladder0.76507267
91MP0002822_catalepsy0.74298687
92MP0003283_abnormal_digestive_organ0.73579833
93MP0000230_abnormal_systemic_arterial0.73382874
94MP0002234_abnormal_pharynx_morphology0.72647876
95MP0002210_abnormal_sex_determination0.72465865
96MP0002067_abnormal_sensory_capabilities0.72313193
97MP0001440_abnormal_grooming_behavior0.72085993
98MP0005423_abnormal_somatic_nervous0.70258308
99MP0004133_heterotaxia0.69495766
100MP0003635_abnormal_synaptic_transmissio0.69410606

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.14018913
2Methylmalonic acidemia (HP:0002912)4.00662136
3Absent rod-and cone-mediated responses on ERG (HP:0007688)4.00152738
4Abnormal rod and cone electroretinograms (HP:0008323)3.74405914
5Acute encephalopathy (HP:0006846)3.66331007
6Pancreatic cysts (HP:0001737)3.55565185
7Abnormal mitochondria in muscle tissue (HP:0008316)3.54474199
8Mitochondrial inheritance (HP:0001427)3.44348354
9Increased CSF lactate (HP:0002490)3.38618370
10Progressive macrocephaly (HP:0004481)3.37326781
11True hermaphroditism (HP:0010459)3.37062979
12Decreased central vision (HP:0007663)3.35907614
13Nephronophthisis (HP:0000090)3.31056221
14Pancreatic fibrosis (HP:0100732)3.21273462
15Abnormality of midbrain morphology (HP:0002418)3.19857235
16Molar tooth sign on MRI (HP:0002419)3.19857235
17Abnormality of cells of the erythroid lineage (HP:0012130)3.12619814
18Reticulocytopenia (HP:0001896)3.03194082
19Retrobulbar optic neuritis (HP:0100654)3.01604971
20Optic neuritis (HP:0100653)3.01604971
21Attenuation of retinal blood vessels (HP:0007843)2.95928492
22Increased hepatocellular lipid droplets (HP:0006565)2.95137466
233-Methylglutaconic aciduria (HP:0003535)2.93220873
24Hepatocellular necrosis (HP:0001404)2.92799597
25Congenital stationary night blindness (HP:0007642)2.91693758
26Methylmalonic aciduria (HP:0012120)2.91290604
27Lipid accumulation in hepatocytes (HP:0006561)2.90686318
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.87923808
29Pendular nystagmus (HP:0012043)2.82627187
30Abnormal number of erythroid precursors (HP:0012131)2.79440954
31Cerebral edema (HP:0002181)2.78979678
32Optic disc pallor (HP:0000543)2.69444986
33Colon cancer (HP:0003003)2.66194347
34Macrocytic anemia (HP:0001972)2.65224513
35Abnormality of the renal medulla (HP:0100957)2.61645332
36Hepatic necrosis (HP:0002605)2.59323268
37Increased serum lactate (HP:0002151)2.56674108
38Reduced antithrombin III activity (HP:0001976)2.56312066
39Decreased electroretinogram (ERG) amplitude (HP:0000654)2.47138597
40Abnormality of the renal cortex (HP:0011035)2.45924581
41Hyperglycinemia (HP:0002154)2.44541320
42Abnormality of the vitamin B12 metabolism (HP:0004341)2.43888418
43Type I transferrin isoform profile (HP:0003642)2.41979040
44Absent thumb (HP:0009777)2.37149732
45Abnormality of vitamin B metabolism (HP:0004340)2.35533905
46Constricted visual fields (HP:0001133)2.32971691
47Orchitis (HP:0100796)2.31766405
48Keratoconus (HP:0000563)2.29461604
49Increased corneal curvature (HP:0100692)2.29461604
50Septo-optic dysplasia (HP:0100842)2.25537469
51Congenital hepatic fibrosis (HP:0002612)2.25226507
52Abolished electroretinogram (ERG) (HP:0000550)2.24341091
53Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.23874540
54Hypoproteinemia (HP:0003075)2.22940651
55Medial flaring of the eyebrow (HP:0010747)2.20317219
56Type II lissencephaly (HP:0007260)2.19369841
57Hypoplasia of the pons (HP:0012110)2.19204306
58Stomatitis (HP:0010280)2.19188904
59Lactic acidosis (HP:0003128)2.19066515
60Renal cortical cysts (HP:0000803)2.12387587
61Abnormality of the pons (HP:0007361)2.10406836
62Tubulointerstitial fibrosis (HP:0005576)2.09017078
63Bony spicule pigmentary retinopathy (HP:0007737)2.08749437
64Aplasia/Hypoplasia of the spleen (HP:0010451)2.07773749
65Exercise intolerance (HP:0003546)2.06909325
66Elevated erythrocyte sedimentation rate (HP:0003565)2.02289877
67Lethargy (HP:0001254)2.01421755
68Ketosis (HP:0001946)1.93941762
69Anencephaly (HP:0002323)1.93390809
70Decreased activity of mitochondrial respiratory chain (HP:0008972)1.92839972
71Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.92839972
72Adactyly (HP:0009776)1.92572566
73Large for gestational age (HP:0001520)1.92471097
74Abnormality of the labia minora (HP:0012880)1.91612560
75Abnormality of dicarboxylic acid metabolism (HP:0010995)1.91252863
76Dicarboxylic aciduria (HP:0003215)1.91252863
77Asplenia (HP:0001746)1.90870663
78Renal Fanconi syndrome (HP:0001994)1.90788422
79Cystic liver disease (HP:0006706)1.89610099
80Keratoconjunctivitis sicca (HP:0001097)1.89117555
81Abnormal protein glycosylation (HP:0012346)1.89010625
82Abnormal glycosylation (HP:0012345)1.89010625
83Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89010625
84Abnormal protein N-linked glycosylation (HP:0012347)1.89010625
85Abnormality of aspartate family amino acid metabolism (HP:0010899)1.87956503
86Respiratory failure (HP:0002878)1.87016224
87Leukodystrophy (HP:0002415)1.86229605
88Sclerocornea (HP:0000647)1.85824136
89Exertional dyspnea (HP:0002875)1.84800679
90Agitation (HP:0000713)1.83452356
91Abnormality of DNA repair (HP:0003254)1.82849531
92Abnormality of homocysteine metabolism (HP:0010919)1.82528572
93Homocystinuria (HP:0002156)1.82528572
94Increased intramyocellular lipid droplets (HP:0012240)1.82011171
95Abnormality of serum amino acid levels (HP:0003112)1.81320636
96Keratoconjunctivitis (HP:0001096)1.80874330
97Hypochromic microcytic anemia (HP:0004840)1.80101016
98Male pseudohermaphroditism (HP:0000037)1.79663195
99Optic nerve hypoplasia (HP:0000609)1.78774530
100Inability to walk (HP:0002540)1.77584514

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K63.82122802
2ZAK3.19715754
3ADRBK22.73978798
4BCKDK2.73127761
5NUAK12.66584145
6TSSK62.62997401
7TLK12.59436436
8VRK22.49162640
9PINK12.40796006
10GRK12.39084812
11TIE12.30508600
12TXK2.29233033
13WNK42.25245108
14STK162.16992814
15TAF11.93595020
16DYRK21.89719528
17MST41.86911290
18PASK1.86005597
19FRK1.72745178
20STK391.62408584
21BMPR1B1.55645115
22WNK31.45938188
23CAMKK21.37642678
24NME11.26415442
25PBK1.25291580
26NLK1.24703699
27VRK11.23982632
28TAOK31.16150313
29OXSR11.16014088
30MKNK21.13947199
31NEK11.12180005
32PLK31.11839285
33MAPK131.10295841
34PHKG11.09426474
35PHKG21.09426474
36ITK1.02327206
37CDK191.00791956
38TRIM280.99473373
39TEC0.98957397
40CSNK1G30.98797291
41WNK10.96847052
42EIF2AK30.96247348
43DAPK20.93610655
44CSNK1G10.93438653
45PRKCG0.91529855
46MARK10.91209028
47CDC70.91006437
48CSNK1G20.89025904
49CAMKK10.87703959
50NTRK20.86953881
51CSNK1A1L0.85954782
52CASK0.84618169
53MKNK10.84566604
54ATR0.81364096
55PLK20.77280144
56ADRBK10.77084790
57INSRR0.75184767
58MAP2K70.74220540
59TGFBR10.72982633
60RPS6KA50.72697221
61PLK40.70384568
62IKBKE0.66112260
63IKBKB0.65621063
64GRK50.63351011
65PRKCH0.61783203
66PRKCQ0.59504518
67MINK10.59493160
68CSNK1A10.59233264
69CSNK1E0.58939222
70CSNK2A20.57163963
71PRKCE0.56626028
72PNCK0.53159967
73EPHA40.51458644
74CAMK2D0.51332766
75MAP4K10.50257168
76BCR0.48218266
77TNIK0.48158545
78CAMK2A0.47636417
79PRKACA0.47281851
80KIT0.47116621
81DYRK1B0.47006829
82CSNK2A10.44656608
83EIF2AK10.43796406
84NME20.43459743
85PLK10.41113941
86ALK0.40905638
87DAPK30.40620606
88STK110.40456652
89MAP3K40.37994577
90PIK3CA0.37707906
91JAK30.37589134
92PAK30.36637057
93PRKCA0.35203201
94RPS6KA60.34710619
95ATM0.33786393
96CAMK1D0.33353522
97ABL20.31421912
98OBSCN0.29946925
99MAP4K20.29364596
100EIF2AK20.28403474

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.54562417
2Proteasome_Homo sapiens_hsa030503.48909403
3Oxidative phosphorylation_Homo sapiens_hsa001903.15820133
4One carbon pool by folate_Homo sapiens_hsa006702.98226276
5Protein export_Homo sapiens_hsa030602.92482149
6RNA polymerase_Homo sapiens_hsa030202.92432106
7Parkinsons disease_Homo sapiens_hsa050122.76981612
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.76032527
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.30439555
10Propanoate metabolism_Homo sapiens_hsa006402.16503280
11Phototransduction_Homo sapiens_hsa047442.03456073
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.00118596
13Asthma_Homo sapiens_hsa053101.99577820
14Huntingtons disease_Homo sapiens_hsa050161.88079515
15Basal transcription factors_Homo sapiens_hsa030221.82996511
16Butanoate metabolism_Homo sapiens_hsa006501.76078642
17RNA degradation_Homo sapiens_hsa030181.74885254
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71759513
19Alzheimers disease_Homo sapiens_hsa050101.65071163
20Homologous recombination_Homo sapiens_hsa034401.61639619
21Cardiac muscle contraction_Homo sapiens_hsa042601.60483563
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.60089647
23Allograft rejection_Homo sapiens_hsa053301.55825425
24Linoleic acid metabolism_Homo sapiens_hsa005911.54413129
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51816750
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.49572359
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.47126592
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.44158899
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43450602
30Autoimmune thyroid disease_Homo sapiens_hsa053201.38073192
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32873888
32Pyrimidine metabolism_Homo sapiens_hsa002401.32513005
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.30460284
34Vitamin B6 metabolism_Homo sapiens_hsa007501.27655553
35Tryptophan metabolism_Homo sapiens_hsa003801.25409612
36Caffeine metabolism_Homo sapiens_hsa002321.22096850
37Type I diabetes mellitus_Homo sapiens_hsa049401.19744358
38Purine metabolism_Homo sapiens_hsa002301.16998350
39Mismatch repair_Homo sapiens_hsa034301.16761348
40RNA transport_Homo sapiens_hsa030131.13662360
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09924367
42Fatty acid biosynthesis_Homo sapiens_hsa000611.08372297
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07806675
44Base excision repair_Homo sapiens_hsa034101.04059997
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03302617
46Nitrogen metabolism_Homo sapiens_hsa009100.99201544
47Fanconi anemia pathway_Homo sapiens_hsa034600.97114035
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95891333
49Nucleotide excision repair_Homo sapiens_hsa034200.94469052
50Steroid biosynthesis_Homo sapiens_hsa001000.90481256
51Peroxisome_Homo sapiens_hsa041460.88875282
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.85225062
53Olfactory transduction_Homo sapiens_hsa047400.81559251
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81029172
55Graft-versus-host disease_Homo sapiens_hsa053320.80611337
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80545559
57Ether lipid metabolism_Homo sapiens_hsa005650.79890639
58Metabolic pathways_Homo sapiens_hsa011000.77521424
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.73901145
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72706560
61Nicotine addiction_Homo sapiens_hsa050330.69701205
62Pyruvate metabolism_Homo sapiens_hsa006200.68464642
63Arachidonic acid metabolism_Homo sapiens_hsa005900.66270767
64Retinol metabolism_Homo sapiens_hsa008300.65287589
65Spliceosome_Homo sapiens_hsa030400.63927573
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63793287
67DNA replication_Homo sapiens_hsa030300.61896727
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60666867
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.59696752
70Fatty acid degradation_Homo sapiens_hsa000710.59153285
71Chemical carcinogenesis_Homo sapiens_hsa052040.58729263
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54299837
73Insulin secretion_Homo sapiens_hsa049110.52701730
74Fat digestion and absorption_Homo sapiens_hsa049750.51667369
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51329464
76Regulation of autophagy_Homo sapiens_hsa041400.50749222
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50149596
78beta-Alanine metabolism_Homo sapiens_hsa004100.49166332
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48919070
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48691295
81Hedgehog signaling pathway_Homo sapiens_hsa043400.44981662
82Folate biosynthesis_Homo sapiens_hsa007900.44651247
83Morphine addiction_Homo sapiens_hsa050320.43634746
84Ovarian steroidogenesis_Homo sapiens_hsa049130.43151906
85Sulfur metabolism_Homo sapiens_hsa009200.42756702
86Mineral absorption_Homo sapiens_hsa049780.41784041
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41505068
88Arginine and proline metabolism_Homo sapiens_hsa003300.37991657
89Sulfur relay system_Homo sapiens_hsa041220.37728860
90Selenocompound metabolism_Homo sapiens_hsa004500.37121531
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.36918704
92Fatty acid metabolism_Homo sapiens_hsa012120.35408755
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34000140
94Starch and sucrose metabolism_Homo sapiens_hsa005000.33977569
95Glycerolipid metabolism_Homo sapiens_hsa005610.33453333
96Hematopoietic cell lineage_Homo sapiens_hsa046400.33240298
97Non-homologous end-joining_Homo sapiens_hsa034500.32451152
98Serotonergic synapse_Homo sapiens_hsa047260.32046630
99Rheumatoid arthritis_Homo sapiens_hsa053230.30340795
100Primary immunodeficiency_Homo sapiens_hsa053400.29553277

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