RPL5P16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)7.53578106
2regulation of antigen processing and presentation of peptide antigen (GO:0002583)7.20310663
3cellular ketone body metabolic process (GO:0046950)6.71867858
4natural killer cell activation involved in immune response (GO:0002323)6.14385830
5ketone body metabolic process (GO:1902224)5.92782533
6regulation of oxidative stress-induced neuron death (GO:1903203)5.70873582
7positive regulation of heterotypic cell-cell adhesion (GO:0034116)5.67858279
8positive regulation of protein homodimerization activity (GO:0090073)5.51932414
9regulation of heterotypic cell-cell adhesion (GO:0034114)5.11156388
10peripheral nervous system neuron development (GO:0048935)4.99591764
11sphingoid metabolic process (GO:0046519)4.84774646
12lactate metabolic process (GO:0006089)4.78527393
13germinal center formation (GO:0002467)4.55855949
14high-density lipoprotein particle remodeling (GO:0034375)4.43458037
15regulation of meiosis I (GO:0060631)4.25107553
16reverse cholesterol transport (GO:0043691)4.22003927
17glyoxylate metabolic process (GO:0046487)4.15752205
18positive regulation of vasculogenesis (GO:2001214)4.11682791
19regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.05806961
20adenosine metabolic process (GO:0046085)3.89308577
21phospholipid efflux (GO:0033700)3.85507526
22interleukin-6-mediated signaling pathway (GO:0070102)3.79306447
23triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.76612852
24diol metabolic process (GO:0034311)3.62609096
25histone H2A ubiquitination (GO:0033522)3.60396184
26respiratory chain complex IV assembly (GO:0008535)3.52950024
27L-fucose metabolic process (GO:0042354)3.52378289
28L-fucose catabolic process (GO:0042355)3.52378289
29fucose catabolic process (GO:0019317)3.52378289
30water-soluble vitamin biosynthetic process (GO:0042364)3.45712097
31aldehyde catabolic process (GO:0046185)3.45142842
32negative regulation of cAMP-mediated signaling (GO:0043951)3.43418868
33detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.42284843
34flavonoid metabolic process (GO:0009812)3.36190135
35regulation of cholesterol esterification (GO:0010872)3.35827894
36short-chain fatty acid metabolic process (GO:0046459)3.34121282
37thrombin receptor signaling pathway (GO:0070493)3.33973308
38cellular copper ion homeostasis (GO:0006878)3.32504567
39cell migration in hindbrain (GO:0021535)3.29636279
40preassembly of GPI anchor in ER membrane (GO:0016254)3.29428533
41regulation of germinal center formation (GO:0002634)3.28052831
42cytochrome complex assembly (GO:0017004)3.27818182
43L-ascorbic acid metabolic process (GO:0019852)3.27721079
44regulation of mitochondrial translation (GO:0070129)3.24953324
45negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.24175909
46regulation of vasculogenesis (GO:2001212)3.22730833
47cholesterol catabolic process (GO:0006707)3.18126503
48sterol catabolic process (GO:0016127)3.18126503
49regulation of antigen processing and presentation (GO:0002577)3.15410228
50myoblast migration (GO:0051451)3.11277323
51glucuronate metabolic process (GO:0019585)3.09018184
52uronic acid metabolic process (GO:0006063)3.09018184
53ovulation from ovarian follicle (GO:0001542)3.08728973
54negative regulation of Rho protein signal transduction (GO:0035024)3.08280510
55regulation of cytokine secretion involved in immune response (GO:0002739)3.06247366
56sphingosine metabolic process (GO:0006670)3.01378755
57signal peptide processing (GO:0006465)3.00895269
58histone H2A monoubiquitination (GO:0035518)3.00325258
59negative regulation of protein oligomerization (GO:0032460)2.98973246
60regulation of translation in response to stress (GO:0043555)2.98241606
61UDP-N-acetylglucosamine metabolic process (GO:0006047)2.96751936
62C-terminal protein amino acid modification (GO:0018410)2.95092815
63negative regulation of cytokine production involved in immune response (GO:0002719)2.92877008
64positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.92255110
65plasma lipoprotein particle assembly (GO:0034377)2.91939213
66S-adenosylmethionine metabolic process (GO:0046500)2.90461410
67cell wall macromolecule metabolic process (GO:0044036)2.89039548
68regulation of memory T cell differentiation (GO:0043380)2.89031361
69cellular response to ethanol (GO:0071361)2.88170644
70cell wall macromolecule catabolic process (GO:0016998)2.87262919
71COPII vesicle coating (GO:0048208)2.85930657
72negative regulation of thymocyte apoptotic process (GO:0070244)2.85675552
73bile acid biosynthetic process (GO:0006699)2.83108370
74positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.83008354
75gamma-aminobutyric acid transport (GO:0015812)2.82819097
76protein K11-linked deubiquitination (GO:0035871)2.82165956
77regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.79332103
78plasma lipoprotein particle remodeling (GO:0034369)2.79251102
79protein-lipid complex remodeling (GO:0034368)2.79251102
80macromolecular complex remodeling (GO:0034367)2.79251102
81negative regulation of B cell apoptotic process (GO:0002903)2.77890683
82lateral ventricle development (GO:0021670)2.77723047
83positive regulation of glycolytic process (GO:0045821)2.76941471
84positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.75691885
85piRNA metabolic process (GO:0034587)2.74790031
86L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.74747969
87immunoglobulin mediated immune response (GO:0016064)2.74223294
88platelet dense granule organization (GO:0060155)2.73664845
89megakaryocyte development (GO:0035855)2.72633721
90phagocytosis, recognition (GO:0006910)2.71099047
91hemoglobin metabolic process (GO:0020027)2.69221130
92phosphatidylcholine biosynthetic process (GO:0006656)2.67753032
93growth hormone receptor signaling pathway (GO:0060396)2.66701233
94auditory receptor cell stereocilium organization (GO:0060088)2.64906186
95amino acid salvage (GO:0043102)2.64886657
96L-methionine salvage (GO:0071267)2.64886657
97L-methionine biosynthetic process (GO:0071265)2.64886657
98copper ion homeostasis (GO:0055070)2.62553489
99C21-steroid hormone metabolic process (GO:0008207)2.61454583
100cardiovascular system development (GO:0072358)2.61028229

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.02424406
2VDR_22108803_ChIP-Seq_LS180_Human3.91497452
3EGR1_23403033_ChIP-Seq_LIVER_Mouse3.88752874
4GBX2_23144817_ChIP-Seq_PC3_Human3.30959606
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.07341208
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.92381734
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.90732341
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.83233478
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.58459302
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.17942926
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12543681
12HTT_18923047_ChIP-ChIP_STHdh_Human2.12491827
13FLI1_27457419_Chip-Seq_LIVER_Mouse1.98738862
14CBP_20019798_ChIP-Seq_JUKART_Human1.97463649
15IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.97463649
16BP1_19119308_ChIP-ChIP_Hs578T_Human1.83365765
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.82719967
18EWS_26573619_Chip-Seq_HEK293_Human1.81238753
19ER_23166858_ChIP-Seq_MCF-7_Human1.79716618
20EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76686495
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.71910762
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70715220
23TP53_22573176_ChIP-Seq_HFKS_Human1.69903088
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69169260
25EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.69070909
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.67051817
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.63982455
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59070335
29NANOG_19829295_ChIP-Seq_ESCs_Human1.57049814
30SOX2_19829295_ChIP-Seq_ESCs_Human1.57049814
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55090728
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54989234
33AUTS2_25519132_ChIP-Seq_293T-REX_Human1.53983152
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.52054585
35GATA3_21878914_ChIP-Seq_MCF-7_Human1.51358273
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49523512
37NR3C1_21868756_ChIP-Seq_MCF10A_Human1.49294058
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45061037
39GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.43796161
40SALL4_22934838_ChIP-ChIP_CD34+_Human1.39888079
41P300_19829295_ChIP-Seq_ESCs_Human1.37776076
42BCAT_22108803_ChIP-Seq_LS180_Human1.36622845
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35723924
44TP53_16413492_ChIP-PET_HCT116_Human1.31110782
45TCF4_22108803_ChIP-Seq_LS180_Human1.30049024
46LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29515654
47SMAD4_21799915_ChIP-Seq_A2780_Human1.28810974
48CIITA_25753668_ChIP-Seq_RAJI_Human1.28504805
49AR_20517297_ChIP-Seq_VCAP_Human1.27967921
50TCF4_23295773_ChIP-Seq_U87_Human1.26697212
51KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26623509
52NCOR_22424771_ChIP-Seq_293T_Human1.26544573
53ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.26294424
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26005623
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20912397
56FOXH1_21741376_ChIP-Seq_EPCs_Human1.16805400
57CDX2_22108803_ChIP-Seq_LS180_Human1.16752654
58FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15963438
59FOXA1_25329375_ChIP-Seq_VCAP_Human1.15963438
60BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15439164
61KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15004907
62IGF1R_20145208_ChIP-Seq_DFB_Human1.14137286
63VDR_23849224_ChIP-Seq_CD4+_Human1.13844132
64PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.13207660
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.12434901
66ESR1_21235772_ChIP-Seq_MCF-7_Human1.12401995
67IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12206127
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10121842
69GATA3_26560356_Chip-Seq_TH2_Human1.09547080
70FLI1_21867929_ChIP-Seq_TH2_Mouse1.07798865
71FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07526320
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07094752
73HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06080187
74STAT3_23295773_ChIP-Seq_U87_Human1.05588712
75MYC_18940864_ChIP-ChIP_HL60_Human1.05343185
76JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04962596
77PHF8_20622853_ChIP-Seq_HELA_Human1.01723848
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.01683034
79IRF8_21731497_ChIP-ChIP_J774_Mouse0.99109000
80PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97238323
81IRF1_19129219_ChIP-ChIP_H3396_Human0.97021128
82ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96700083
83BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.96226581
84ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95906366
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95490139
86GATA3_27048872_Chip-Seq_THYMUS_Human0.95296181
87RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93992066
88EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93537534
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93504043
90FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93227866
91STAT1_20625510_ChIP-Seq_HELA_Human0.92849821
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92266739
93GATA3_26560356_Chip-Seq_TH1_Human0.91857941
94PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90701200
95E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.90363225
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89997713
97TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89848055
98AR_21572438_ChIP-Seq_LNCaP_Human0.89127705
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88853060
100CJUN_26792858_Chip-Seq_BT549_Human0.88639811

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis5.67970635
2MP0002138_abnormal_hepatobiliary_system4.50581573
3MP0006054_spinal_hemorrhage4.42310811
4MP0001986_abnormal_taste_sensitivity4.34163423
5MP0008057_abnormal_DNA_replication3.47536285
6MP0004084_abnormal_cardiac_muscle3.32075215
7MP0003646_muscle_fatigue3.22047740
8MP0008775_abnormal_heart_ventricle3.16134191
9MP0000516_abnormal_urinary_system2.75927049
10MP0005367_renal/urinary_system_phenotyp2.75927049
11MP0005167_abnormal_blood-brain_barrier2.75028534
12MP0002254_reproductive_system_inflammat2.73669183
13MP0005075_abnormal_melanosome_morpholog2.56735231
14MP0001835_abnormal_antigen_presentation2.51251462
15MP0008007_abnormal_cellular_replicative2.40105022
16MP0004019_abnormal_vitamin_homeostasis2.02585727
17MP0010329_abnormal_lipoprotein_level2.01370571
18MP0004036_abnormal_muscle_relaxation1.99610601
19MP0002332_abnormal_exercise_endurance1.94053335
20MP0002166_altered_tumor_susceptibility1.93263757
21MP0002006_tumorigenesis1.84622072
22MP0008995_early_reproductive_senescence1.78953089
23MP0003786_premature_aging1.71569247
24MP0008872_abnormal_physiological_respon1.68647887
25MP0005423_abnormal_somatic_nervous1.61352043
26MP0005365_abnormal_bile_salt1.59984147
27MP0003191_abnormal_cellular_cholesterol1.58161511
28MP0005085_abnormal_gallbladder_physiolo1.47745510
29MP0002653_abnormal_ependyma_morphology1.42966596
30MP0002876_abnormal_thyroid_physiology1.36762966
31MP0005410_abnormal_fertilization1.36441232
32MP0004381_abnormal_hair_follicle1.29811945
33MP0000538_abnormal_urinary_bladder1.28433799
34MP0004264_abnormal_extraembryonic_tissu1.23016190
35MP0000647_abnormal_sebaceous_gland1.21154215
36MP0002638_abnormal_pupillary_reflex1.20589220
37MP0001756_abnormal_urination1.18316791
38MP0002909_abnormal_adrenal_gland1.18223341
39MP0003943_abnormal_hepatobiliary_system1.17252137
40MP0006276_abnormal_autonomic_nervous1.15431659
41MP0009840_abnormal_foam_cell1.15108952
42MP0005408_hypopigmentation1.12775374
43MP0003941_abnormal_skin_development1.12054082
44MP0000685_abnormal_immune_system1.11599296
45MP0001542_abnormal_bone_strength1.08984509
46MP0001929_abnormal_gametogenesis1.08397619
47MP0001853_heart_inflammation1.06030596
48MP0008875_abnormal_xenobiotic_pharmacok1.05958745
49MP0005636_abnormal_mineral_homeostasis1.05823090
50MP0005266_abnormal_metabolism1.03363001
51MP0004043_abnormal_pH_regulation1.02866422
52MP0004782_abnormal_surfactant_physiolog1.02319898
53MP0005551_abnormal_eye_electrophysiolog1.02097475
54MP0001501_abnormal_sleep_pattern0.94882566
55MP0001915_intracranial_hemorrhage0.93685994
56MP0009764_decreased_sensitivity_to0.92122639
57MP0000613_abnormal_salivary_gland0.90640793
58MP0004142_abnormal_muscle_tone0.89961520
59MP0002136_abnormal_kidney_physiology0.89155554
60MP0004147_increased_porphyrin_level0.85988702
61MP0002168_other_aberrant_phenotype0.85736464
62MP0001119_abnormal_female_reproductive0.85695482
63MP0005165_increased_susceptibility_to0.84125539
64MP0001968_abnormal_touch/_nociception0.83630614
65MP0000377_abnormal_hair_follicle0.83246735
66MP0005332_abnormal_amino_acid0.83168601
67MP0002736_abnormal_nociception_after0.82504545
68MP0003880_abnormal_central_pattern0.82234125
69MP0009643_abnormal_urine_homeostasis0.81707271
70MP0005360_urolithiasis0.80849040
71MP0005084_abnormal_gallbladder_morpholo0.78640581
72MP0002295_abnormal_pulmonary_circulatio0.76522545
73MP0002751_abnormal_autonomic_nervous0.75851829
74MP0003718_maternal_effect0.75034346
75MP0003186_abnormal_redox_activity0.74818572
76MP0000639_abnormal_adrenal_gland0.72600006
77MP0002272_abnormal_nervous_system0.71974841
78MP0004924_abnormal_behavior0.71276099
79MP0005386_behavior/neurological_phenoty0.71276099
80MP0000653_abnormal_sex_gland0.69511175
81MP0008058_abnormal_DNA_repair0.69269162
82MP0005395_other_phenotype0.67222508
83MP0000427_abnormal_hair_cycle0.66329613
84MP0002735_abnormal_chemical_nociception0.65290579
85MP0002127_abnormal_cardiovascular_syste0.63112242
86MP0001765_abnormal_ion_homeostasis0.62847055
87MP0005023_abnormal_wound_healing0.61962635
88MP0009745_abnormal_behavioral_response0.61809975
89MP0003698_abnormal_male_reproductive0.61652401
90MP0000598_abnormal_liver_morphology0.61519780
91MP0005535_abnormal_body_temperature0.60761076
92MP0001486_abnormal_startle_reflex0.59844207
93MP0000609_abnormal_liver_physiology0.59452012
94MP0005376_homeostasis/metabolism_phenot0.56298145
95MP0005671_abnormal_response_to0.55633494
96MP0006036_abnormal_mitochondrial_physio0.55555144
97MP0002088_abnormal_embryonic_growth/wei0.54024160
98MP0003252_abnormal_bile_duct0.53878281
99MP0003984_embryonic_growth_retardation0.52272433
100MP0001661_extended_life_span0.51544235

Predicted human phenotypes

RankGene SetZ-score
13-Methylglutaconic aciduria (HP:0003535)7.47625887
2Methylmalonic acidemia (HP:0002912)5.13076338
3Chronic hepatic failure (HP:0100626)4.83721425
4Abnormality of the vitamin B12 metabolism (HP:0004341)4.69048207
5Spontaneous abortion (HP:0005268)4.67710219
6Abnormality of vitamin B metabolism (HP:0004340)4.54479143
7Cerebellar dysplasia (HP:0007033)4.37291263
8Large eyes (HP:0001090)4.36096519
9Congenital, generalized hypertrichosis (HP:0004540)4.23753481
10Methylmalonic aciduria (HP:0012120)3.98088467
11Fair hair (HP:0002286)3.94413251
12Intrahepatic cholestasis (HP:0001406)3.65235526
13Papillary thyroid carcinoma (HP:0002895)3.50698324
14Type II lissencephaly (HP:0007260)3.43593242
15Abnormality of secondary sexual hair (HP:0009888)3.40585538
16Abnormality of the axillary hair (HP:0100134)3.40585538
17Dry hair (HP:0011359)3.39930127
18Abnormality of vitamin metabolism (HP:0100508)3.32213886
19Amelogenesis imperfecta (HP:0000705)3.29555107
20Increased corneal curvature (HP:0100692)3.25563399
21Keratoconus (HP:0000563)3.25563399
22Abnormality of the common coagulation pathway (HP:0010990)3.18253640
23Hypobetalipoproteinemia (HP:0003563)3.09306450
24Ankle contracture (HP:0006466)3.04070653
25Neoplasm of the adrenal cortex (HP:0100641)3.00027265
26Generalized hypopigmentation of hair (HP:0011358)2.96306660
27Abnormality of the pons (HP:0007361)2.91844256
28Gingival bleeding (HP:0000225)2.90792494
29Thyroid carcinoma (HP:0002890)2.90644001
30Vascular calcification (HP:0004934)2.77932947
31Subaortic stenosis (HP:0001682)2.77172440
32Abnormality of the left ventricular outflow tract (HP:0011103)2.77172440
33Neoplasm of the adrenal gland (HP:0100631)2.74101041
34Elevated erythrocyte sedimentation rate (HP:0003565)2.71215450
35Fat malabsorption (HP:0002630)2.67307061
36Abnormality of alanine metabolism (HP:0010916)2.66520436
37Hyperalaninemia (HP:0003348)2.66520436
38Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.66520436
39Hypoplasia of the pons (HP:0012110)2.64596662
40Sparse eyelashes (HP:0000653)2.63889395
41Microvesicular hepatic steatosis (HP:0001414)2.55159306
42Steatorrhea (HP:0002570)2.52103445
43Cardiovascular calcification (HP:0011915)2.51138488
44Sparse scalp hair (HP:0002209)2.49905796
45Abnormality of dicarboxylic acid metabolism (HP:0010995)2.49465198
46Dicarboxylic aciduria (HP:0003215)2.49465198
47Hypolipoproteinemia (HP:0010981)2.49394004
48Pendular nystagmus (HP:0012043)2.45123444
49Abnormality of the fingertips (HP:0001211)2.43615425
50Delayed CNS myelination (HP:0002188)2.36803332
51Chorioretinal atrophy (HP:0000533)2.31894924
52Attenuation of retinal blood vessels (HP:0007843)2.21221796
53Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.17242867
54Abnormal hair whorl (HP:0010721)2.16199284
55Ridged nail (HP:0001807)2.14766548
56Abolished electroretinogram (ERG) (HP:0000550)2.14575752
57Retinal atrophy (HP:0001105)2.13283855
58Broad alveolar ridges (HP:0000187)2.11396280
59Amyloidosis (HP:0011034)2.09814780
60Adactyly (HP:0009776)2.09490336
61Dynein arm defect of respiratory motile cilia (HP:0012255)2.08953636
62Absent/shortened dynein arms (HP:0200106)2.08953636
63Stomach cancer (HP:0012126)2.05365688
64Patent foramen ovale (HP:0001655)2.03439702
65Increased CSF lactate (HP:0002490)2.01501409
66Reduced subcutaneous adipose tissue (HP:0003758)1.99371736
67Concave nail (HP:0001598)1.95653354
68Supernumerary spleens (HP:0009799)1.95184602
69Severe muscular hypotonia (HP:0006829)1.94820168
70Horizontal nystagmus (HP:0000666)1.93388256
71Increased hepatocellular lipid droplets (HP:0006565)1.92885515
72Chronic sinusitis (HP:0011109)1.90723610
73Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.89813498
74Myocardial infarction (HP:0001658)1.89557618
75Eosinophilia (HP:0001880)1.89333521
76Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.88816616
77CNS demyelination (HP:0007305)1.88324655
78CNS hypomyelination (HP:0003429)1.87832022
79Chronic otitis media (HP:0000389)1.87347522
80Renovascular hypertension (HP:0100817)1.83793259
81Hypophosphatemic rickets (HP:0004912)1.83028209
82Decreased circulating renin level (HP:0003351)1.81877659
83Distal arthrogryposis (HP:0005684)1.80459078
84Sclerocornea (HP:0000647)1.78897494
85Congenital stationary night blindness (HP:0007642)1.78674775
86Ketoacidosis (HP:0001993)1.77402496
87Atonic seizures (HP:0010819)1.77303202
88Hypokalemic alkalosis (HP:0001949)1.77239598
89Abnormality of dental color (HP:0011073)1.76344779
90Mitral stenosis (HP:0001718)1.75669599
91Malnutrition (HP:0004395)1.75203916
92Cutaneous melanoma (HP:0012056)1.74134669
93Hypoproteinemia (HP:0003075)1.73878751
94High anterior hairline (HP:0009890)1.72756414
95Hypoalphalipoproteinemia (HP:0003233)1.72712891
96Cerebral hypomyelination (HP:0006808)1.72170124
97Amyotrophic lateral sclerosis (HP:0007354)1.71463140
98Bicuspid aortic valve (HP:0001647)1.70773512
99Bony spicule pigmentary retinopathy (HP:0007737)1.68630379
100Lipid accumulation in hepatocytes (HP:0006561)1.67882503

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK169.22645702
2FRK5.14280990
3PDK24.47753950
4EEF2K3.51577050
5BMPR1B3.46087450
6MAPKAPK33.38369332
7INSRR3.09507898
8EIF2AK32.77206703
9EIF2AK12.32426952
10ZAK2.28402359
11MAP3K132.28040589
12ADRBK22.20930233
13PLK21.88505912
14GRK11.74312343
15TIE11.66615888
16MET1.65652655
17MAPKAPK51.48910140
18RPS6KB21.44092589
19TLK11.31321315
20TRPM71.29534883
21PLK31.18372612
22TAOK31.16718480
23VRK11.09217736
24ACVR1B1.06763940
25MAPK131.04734711
26NUAK11.02908570
27NLK0.95911817
28FER0.93794620
29MAP3K140.87048932
30TNIK0.84187258
31MAPK120.82341396
32GRK50.79962271
33PBK0.78941342
34MAPK70.77285716
35STK38L0.76702185
36MAPK110.73888065
37WNK30.72383295
38PINK10.69443644
39STK240.69153641
40IKBKB0.67329871
41FGFR20.65385597
42TEC0.64940088
43CHUK0.64154994
44WNK40.63199048
45ABL20.60282874
46PAK30.59909114
47PRKCE0.57527159
48SIK20.56564147
49IRAK10.56182648
50PTK2B0.54587910
51NEK60.53168513
52CAMKK20.52125214
53PHKG10.50198523
54PHKG20.50198523
55PRKCI0.50084296
56PRKAA20.44810255
57CAMK40.43929968
58AKT30.43929882
59EIF2AK20.42476864
60NTRK30.42040006
61STK30.41612336
62ADRBK10.39563179
63CAMK10.39416586
64MST40.36354244
65IRAK30.31859314
66VRK20.31681400
67OXSR10.31066287
68PRKAA10.30594974
69EPHA30.29510037
70CSNK1G10.27495882
71MKNK20.27435680
72ERBB30.25809925
73SIK30.25087475
74RPS6KA50.24954960
75KDR0.24101266
76CAMK1D0.24051514
77MAP3K70.23124522
78CSNK1D0.20801309
79PRKCZ0.20322218
80STK380.20065099
81RET0.19379071
82STK40.18769637
83CAMK1G0.18462314
84CSNK2A10.18095956
85RPS6KB10.18036421
86PIK3CG0.17635868
87LRRK20.14626167
88MINK10.14492017
89PDPK10.12494123
90STK390.12393398
91TGFBR10.12380626
92EPHA40.12197904
93CHEK20.12027141
94MAP3K20.11382768
95CSNK1A10.10210879
96ATM0.09986411
97PKN10.09834782
98TNK20.09793972
99ABL10.08957826
100MAPKAPK20.07892674

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.33987732
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.27451095
3Asthma_Homo sapiens_hsa053102.95392027
4Nitrogen metabolism_Homo sapiens_hsa009102.89489955
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.73808222
6Propanoate metabolism_Homo sapiens_hsa006402.72106277
7Allograft rejection_Homo sapiens_hsa053302.59458513
8Systemic lupus erythematosus_Homo sapiens_hsa053222.54751573
9Graft-versus-host disease_Homo sapiens_hsa053322.51680870
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.49791273
11Autoimmune thyroid disease_Homo sapiens_hsa053202.42049552
12Butanoate metabolism_Homo sapiens_hsa006502.41227505
13Selenocompound metabolism_Homo sapiens_hsa004502.30507646
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.23700291
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.11544932
16Type I diabetes mellitus_Homo sapiens_hsa049402.09076786
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.02186334
18Staphylococcus aureus infection_Homo sapiens_hsa051501.99181711
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.81542368
20Fat digestion and absorption_Homo sapiens_hsa049751.76605343
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.76020875
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73731588
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.70431414
24Complement and coagulation cascades_Homo sapiens_hsa046101.65624537
25Linoleic acid metabolism_Homo sapiens_hsa005911.58741382
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.51506491
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.50065167
28Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.40990037
29Vitamin digestion and absorption_Homo sapiens_hsa049771.34087372
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.31295692
31Fatty acid elongation_Homo sapiens_hsa000621.30773046
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.29941001
33Chemical carcinogenesis_Homo sapiens_hsa052041.29017853
34Rheumatoid arthritis_Homo sapiens_hsa053231.27470914
35ABC transporters_Homo sapiens_hsa020101.23057821
36Peroxisome_Homo sapiens_hsa041461.15202411
37Tryptophan metabolism_Homo sapiens_hsa003801.12218270
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10925832
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10914064
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10394240
41Proteasome_Homo sapiens_hsa030501.09099694
42Alcoholism_Homo sapiens_hsa050341.05925193
43Antigen processing and presentation_Homo sapiens_hsa046121.03898932
44Caffeine metabolism_Homo sapiens_hsa002321.00222798
45Leishmaniasis_Homo sapiens_hsa051400.97747859
46Ether lipid metabolism_Homo sapiens_hsa005650.97121916
47Retinol metabolism_Homo sapiens_hsa008300.93929388
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.90299303
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87163768
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86328420
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86206079
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79874494
53PPAR signaling pathway_Homo sapiens_hsa033200.79415499
54Fatty acid degradation_Homo sapiens_hsa000710.78749628
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78498619
56African trypanosomiasis_Homo sapiens_hsa051430.76935043
57Viral myocarditis_Homo sapiens_hsa054160.75995714
58Arginine and proline metabolism_Homo sapiens_hsa003300.72523613
59Sphingolipid metabolism_Homo sapiens_hsa006000.71952035
60Olfactory transduction_Homo sapiens_hsa047400.71551258
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.70126602
62Glutathione metabolism_Homo sapiens_hsa004800.68131239
63Arginine biosynthesis_Homo sapiens_hsa002200.67313323
64Starch and sucrose metabolism_Homo sapiens_hsa005000.65123221
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64993029
66Collecting duct acid secretion_Homo sapiens_hsa049660.57060690
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56217576
68Arachidonic acid metabolism_Homo sapiens_hsa005900.53453416
69Glycerolipid metabolism_Homo sapiens_hsa005610.53055804
70Fatty acid metabolism_Homo sapiens_hsa012120.50409564
71beta-Alanine metabolism_Homo sapiens_hsa004100.48966538
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48705559
73Taste transduction_Homo sapiens_hsa047420.47100985
74Bile secretion_Homo sapiens_hsa049760.44807012
75Pyruvate metabolism_Homo sapiens_hsa006200.44739496
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43487657
77Dorso-ventral axis formation_Homo sapiens_hsa043200.43237664
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42496698
79Other glycan degradation_Homo sapiens_hsa005110.40657304
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.39833340
81Protein digestion and absorption_Homo sapiens_hsa049740.36301418
82Herpes simplex infection_Homo sapiens_hsa051680.33107458
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.32554402
84Metabolic pathways_Homo sapiens_hsa011000.32504712
85Lysine degradation_Homo sapiens_hsa003100.31688292
86Legionellosis_Homo sapiens_hsa051340.30133933
87Oxidative phosphorylation_Homo sapiens_hsa001900.30044209
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.28317349
89Mineral absorption_Homo sapiens_hsa049780.28048815
90Toxoplasmosis_Homo sapiens_hsa051450.25493241
91Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.24126447
92Calcium signaling pathway_Homo sapiens_hsa040200.24039086
93p53 signaling pathway_Homo sapiens_hsa041150.19348269
94Viral carcinogenesis_Homo sapiens_hsa052030.18855421
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.16999606
96Galactose metabolism_Homo sapiens_hsa000520.14165315
97Phagosome_Homo sapiens_hsa041450.13870859
98Serotonergic synapse_Homo sapiens_hsa047260.13141393
99Pentose phosphate pathway_Homo sapiens_hsa000300.11586597
100Phototransduction_Homo sapiens_hsa047440.11260976

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