ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.62123419
2	viral transcription (GO:0019083)	6.27162148
3	translational termination (GO:0006415)	6.04430293
4	maturation of SSU-rRNA (GO:0030490)	5.65484214
5	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.39718538
6	ribosomal small subunit biogenesis (GO:0042274)	5.33547588
7	cotranslational protein targeting to membrane (GO:0006613)	5.29507330
8	protein targeting to ER (GO:0045047)	5.26641648
9	translational elongation (GO:0006414)	5.21645045
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.07872936
11	ATP synthesis coupled proton transport (GO:0015986)	4.99168161
12	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.99168161
13	protein localization to endoplasmic reticulum (GO:0070972)	4.96893698
14	water-soluble vitamin biosynthetic process (GO:0042364)	4.72949047
15	chaperone-mediated protein transport (GO:0072321)	4.63420796
16	viral life cycle (GO:0019058)	4.47926350
17	cellular protein complex disassembly (GO:0043624)	4.46546669
18	DNA deamination (GO:0045006)	4.38306128
19	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.32764110
20	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.30596299
21	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.27512631
22	ribosomal large subunit biogenesis (GO:0042273)	4.22906857
23	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.20192571
24	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.20192571
25	NADH dehydrogenase complex assembly (GO:0010257)	4.20192571
26	translational initiation (GO:0006413)	4.17127248
27	behavioral response to nicotine (GO:0035095)	4.05062029
28	protein complex biogenesis (GO:0070271)	3.99734450
29	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.97742113
30	protein neddylation (GO:0045116)	3.91978621
31	translation (GO:0006412)	3.79891915
32	protein complex disassembly (GO:0043241)	3.73586549
33	mitochondrial respiratory chain complex assembly (GO:0033108)	3.70165354
34	GTP biosynthetic process (GO:0006183)	3.61901547
35	macromolecular complex disassembly (GO:0032984)	3.61409807
36	electron transport chain (GO:0022900)	3.60647177
37	respiratory electron transport chain (GO:0022904)	3.58858535
38	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.55246148
39	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.54617536
40	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.44290610
41	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.44290610
42	protein targeting to membrane (GO:0006612)	3.39007568
43	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.30007631
44	cellular component biogenesis (GO:0044085)	3.27496683
45	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.19670459
46	respiratory chain complex IV assembly (GO:0008535)	3.17057037
47	kynurenine metabolic process (GO:0070189)	3.15505156
48	mRNA catabolic process (GO:0006402)	3.12106156
49	ribonucleoprotein complex biogenesis (GO:0022613)	3.12035716
50	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.11965012
51	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.11273645
52	UTP biosynthetic process (GO:0006228)	3.06313548
53	peptidyl-histidine modification (GO:0018202)	3.03127546
54	ubiquinone biosynthetic process (GO:0006744)	2.99960590
55	tryptophan catabolic process (GO:0006569)	2.97717159
56	indole-containing compound catabolic process (GO:0042436)	2.97717159
57	indolalkylamine catabolic process (GO:0046218)	2.97717159
58	ATP biosynthetic process (GO:0006754)	2.96195580
59	UTP metabolic process (GO:0046051)	2.96190453
60	nonmotile primary cilium assembly (GO:0035058)	2.95459961
61	pseudouridine synthesis (GO:0001522)	2.94705400
62	rRNA metabolic process (GO:0016072)	2.92601285
63	rRNA processing (GO:0006364)	2.92452155
64	protein-cofactor linkage (GO:0018065)	2.92424103
65	tRNA processing (GO:0008033)	2.88952129
66	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.88242995
67	termination of RNA polymerase III transcription (GO:0006386)	2.88242995
68	RNA catabolic process (GO:0006401)	2.86657349
69	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.85002916
70	intracellular protein transmembrane import (GO:0044743)	2.80494800
71	indolalkylamine metabolic process (GO:0006586)	2.77326108
72	regulation of cilium movement (GO:0003352)	2.76945864
73	hydrogen ion transmembrane transport (GO:1902600)	2.76048717
74	base-excision repair, AP site formation (GO:0006285)	2.73287966
75	positive regulation of prostaglandin secretion (GO:0032308)	2.72634084
76	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.71274708
77	preassembly of GPI anchor in ER membrane (GO:0016254)	2.70285232
78	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.70111509
79	maturation of 5.8S rRNA (GO:0000460)	2.66426068
80	pyrimidine nucleotide catabolic process (GO:0006244)	2.64348876
81	cytochrome complex assembly (GO:0017004)	2.64259051
82	mannosylation (GO:0097502)	2.63486956
83	cullin deneddylation (GO:0010388)	2.62526495
84	proton transport (GO:0015992)	2.62327725
85	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.62087785
86	negative regulation of telomere maintenance (GO:0032205)	2.61579006
87	platelet dense granule organization (GO:0060155)	2.59621684
88	hydrogen transport (GO:0006818)	2.59115792
89	ubiquinone metabolic process (GO:0006743)	2.58513400
90	rRNA modification (GO:0000154)	2.57986733
91	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.57789000
92	cell proliferation in forebrain (GO:0021846)	2.57081340
93	rRNA catabolic process (GO:0016075)	2.56686235
94	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.54436726
95	proteasome assembly (GO:0043248)	2.54150029
96	parturition (GO:0007567)	2.53945858
97	male meiosis I (GO:0007141)	2.52757749
98	CTP metabolic process (GO:0046036)	2.52746711
99	CTP biosynthetic process (GO:0006241)	2.52746711
100	anterograde synaptic vesicle transport (GO:0048490)	2.52293915

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.83326284
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.59843908
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.51563967
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.28037137
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.13207821
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.96435062
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.92110700
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.80926110
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.75094552
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.70435702
11	VDR_22108803_ChIP-Seq_LS180_Human	2.67000950
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.58520706
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.34622158
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.17708146
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.09524373
16	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.09310656
17	MYC_18940864_ChIP-ChIP_HL60_Human	1.99965837
18	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.97534712
19	FOXP3_21729870_ChIP-Seq_TREG_Human	1.90150647
20	ELK1_19687146_ChIP-ChIP_HELA_Human	1.76713544
21	IGF1R_20145208_ChIP-Seq_DFB_Human	1.68687327
22	EWS_26573619_Chip-Seq_HEK293_Human	1.66448738
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.65840108
24	TTF2_22483619_ChIP-Seq_HELA_Human	1.56927981
25	TP53_22573176_ChIP-Seq_HFKS_Human	1.56456860
26	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.53236222
27	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.53177848
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.51829744
29	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.51685406
30	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.50977985
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.50044332
32	FUS_26573619_Chip-Seq_HEK293_Human	1.49814317
33	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.47796360
34	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.46134134
35	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.45482631
36	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.37034167
37	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.36879998
38	AR_20517297_ChIP-Seq_VCAP_Human	1.36078323
39	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.34833597
40	TAF15_26573619_Chip-Seq_HEK293_Human	1.33452462
41	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.31049138
42	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.29194470
43	TAF2_19829295_ChIP-Seq_ESCs_Human	1.28560565
44	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.27718627
45	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.26833033
46	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.24866768
47	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.24343198
48	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.24343198
49	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.23204226
50	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.23053354
51	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.22557762
52	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.19541794
53	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.19496317
54	NANOG_20526341_ChIP-Seq_ESCs_Human	1.18953018
55	RNF2_27304074_Chip-Seq_NSC_Mouse	1.17250927
56	NCOR_22424771_ChIP-Seq_293T_Human	1.16803932
57	CBP_20019798_ChIP-Seq_JUKART_Human	1.16252078
58	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.16252078
59	GABP_19822575_ChIP-Seq_HepG2_Human	1.16170861
60	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.15478922
61	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.14746110
62	SOX2_19829295_ChIP-Seq_ESCs_Human	1.13843919
63	NANOG_19829295_ChIP-Seq_ESCs_Human	1.13843919
64	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.12565233
65	P300_19829295_ChIP-Seq_ESCs_Human	1.10436635
66	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.09669072
67	REST_21632747_ChIP-Seq_MESCs_Mouse	1.07375179
68	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.05901683
69	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.05758130
70	MYC_19829295_ChIP-Seq_ESCs_Human	1.05283861
71	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.04687032
72	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.04190791
73	ERA_21632823_ChIP-Seq_H3396_Human	1.03788713
74	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.03542134
75	ER_23166858_ChIP-Seq_MCF-7_Human	1.01715702
76	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.99815508
77	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.99704262
78	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.99421595
79	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.99043159
80	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.98625392
81	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.98580203
82	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.98523721
83	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.98239633
84	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.98230227
85	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.97346166
86	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.96172859
87	CIITA_25753668_ChIP-Seq_RAJI_Human	0.95401804
88	GBX2_23144817_ChIP-Seq_PC3_Human	0.94845498
89	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.94330069
90	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.93243909
91	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.92779581
92	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.92550128
93	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.90787494
94	HOXB7_26014856_ChIP-Seq_BT474_Human	0.89204951
95	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.88972799
96	BCAT_22108803_ChIP-Seq_LS180_Human	0.88686488
97	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.88639739
98	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.88170314
99	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.87790892
100	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.87227906

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.32641445
2	MP0009379_abnormal_foot_pigmentation	3.50674062
3	MP0003787_abnormal_imprinting	3.28122738
4	MP0008877_abnormal_DNA_methylation	2.71653801
5	MP0002163_abnormal_gland_morphology	2.65943292
6	MP0004142_abnormal_muscle_tone	2.60512707
7	MP0006072_abnormal_retinal_apoptosis	2.16306975
8	MP0001986_abnormal_taste_sensitivity	2.15572495
9	MP0004147_increased_porphyrin_level	2.10946286
10	MP0004145_abnormal_muscle_electrophysio	2.10865325
11	MP0008872_abnormal_physiological_respon	1.99879156
12	MP0002138_abnormal_hepatobiliary_system	1.99637195
13	MP0002876_abnormal_thyroid_physiology	1.94009575
14	MP0008789_abnormal_olfactory_epithelium	1.88263497
15	MP0003121_genomic_imprinting	1.85143510
16	MP0005646_abnormal_pituitary_gland	1.85077190
17	MP0005551_abnormal_eye_electrophysiolog	1.84156114
18	MP0002837_dystrophic_cardiac_calcinosis	1.76819532
19	MP0006276_abnormal_autonomic_nervous	1.75533890
20	MP0004885_abnormal_endolymph	1.70697290
21	MP0005084_abnormal_gallbladder_morpholo	1.69435711
22	MP0002102_abnormal_ear_morphology	1.68115876
23	MP0003880_abnormal_central_pattern	1.67516671
24	MP0008875_abnormal_xenobiotic_pharmacok	1.67288270
25	MP0001968_abnormal_touch/_nociception	1.64782834
26	MP0005379_endocrine/exocrine_gland_phen	1.64142553
27	MP0003122_maternal_imprinting	1.63674001
28	MP0002653_abnormal_ependyma_morphology	1.59383188
29	MP0003806_abnormal_nucleotide_metabolis	1.53766859
30	MP0008058_abnormal_DNA_repair	1.51264708
31	MP0002938_white_spotting	1.48894045
32	MP0005645_abnormal_hypothalamus_physiol	1.46766715
33	MP0003646_muscle_fatigue	1.46242644
34	MP0002160_abnormal_reproductive_system	1.46218837
35	MP0003195_calcinosis	1.45784840
36	MP0002272_abnormal_nervous_system	1.45113417
37	MP0001835_abnormal_antigen_presentation	1.39146945
38	MP0005499_abnormal_olfactory_system	1.38374231
39	MP0005394_taste/olfaction_phenotype	1.38374231
40	MP0005389_reproductive_system_phenotype	1.35280214
41	MP0003123_paternal_imprinting	1.35066376
42	MP0000372_irregular_coat_pigmentation	1.33660008
43	MP0001188_hyperpigmentation	1.32652112
44	MP0000631_abnormal_neuroendocrine_gland	1.30853543
45	MP0001293_anophthalmia	1.29451961
46	MP0002736_abnormal_nociception_after	1.28775466
47	MP0002638_abnormal_pupillary_reflex	1.27537235
48	MP0003011_delayed_dark_adaptation	1.26712822
49	MP0009046_muscle_twitch	1.25184306
50	MP0005075_abnormal_melanosome_morpholog	1.24901602
51	MP0002095_abnormal_skin_pigmentation	1.23236330
52	MP0008995_early_reproductive_senescence	1.20487525
53	MP0009745_abnormal_behavioral_response	1.19424684
54	MP0005671_abnormal_response_to	1.19279311
55	MP0005253_abnormal_eye_physiology	1.18977983
56	MP0002234_abnormal_pharynx_morphology	1.17547778
57	MP0008775_abnormal_heart_ventricle	1.16783421
58	MP0001905_abnormal_dopamine_level	1.11170216
59	MP0003136_yellow_coat_color	1.08351647
60	MP0000569_abnormal_digit_pigmentation	1.08154481
61	MP0002557_abnormal_social/conspecific_i	1.07867467
62	MP0004043_abnormal_pH_regulation	1.06814678
63	MP0002184_abnormal_innervation	1.03934935
64	MP0001485_abnormal_pinna_reflex	1.02508226
65	MP0001984_abnormal_olfaction	1.01653439
66	MP0006036_abnormal_mitochondrial_physio	1.00542674
67	MP0005195_abnormal_posterior_eye	0.98485170
68	MP0001970_abnormal_pain_threshold	0.98066504
69	MP0001440_abnormal_grooming_behavior	0.97273669
70	MP0001919_abnormal_reproductive_system	0.97170741
71	MP0001873_stomach_inflammation	0.97085832
72	MP0002733_abnormal_thermal_nociception	0.95881778
73	MP0002572_abnormal_emotion/affect_behav	0.95880212
74	MP0000427_abnormal_hair_cycle	0.95711922
75	MP0002277_abnormal_respiratory_mucosa	0.92909091
76	MP0000049_abnormal_middle_ear	0.92320952
77	MP0005174_abnormal_tail_pigmentation	0.87537981
78	MP0003186_abnormal_redox_activity	0.87525840
79	MP0003567_abnormal_fetal_cardiomyocyte	0.86794639
80	MP0001529_abnormal_vocalization	0.85583088
81	MP0000230_abnormal_systemic_arterial	0.84999205
82	MP0002148_abnormal_hypersensitivity_rea	0.84551796
83	MP0001486_abnormal_startle_reflex	0.84232571
84	MP0002752_abnormal_somatic_nervous	0.84083992
85	MP0000778_abnormal_nervous_system	0.83951933
86	MP0001501_abnormal_sleep_pattern	0.83543762
87	MP0001502_abnormal_circadian_rhythm	0.80401982
88	MP0003786_premature_aging	0.79661936
89	MP0009764_decreased_sensitivity_to	0.79365506
90	MP0003718_maternal_effect	0.78012753
91	MP0003878_abnormal_ear_physiology	0.77381425
92	MP0005377_hearing/vestibular/ear_phenot	0.77381425
93	MP0004133_heterotaxia	0.75466281
94	MP0001663_abnormal_digestive_system	0.73616824
95	MP0005410_abnormal_fertilization	0.73338262
96	MP0002063_abnormal_learning/memory/cond	0.72915153
97	MP0002210_abnormal_sex_determination	0.72586832
98	MP0003283_abnormal_digestive_organ	0.68998847
99	MP0000026_abnormal_inner_ear	0.68353510
100	MP0005332_abnormal_amino_acid	0.68000538

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.57057711
2	Reticulocytopenia (HP:0001896)	4.25935561
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.09543474
4	Acute encephalopathy (HP:0006846)	4.00451764
5	Mitochondrial inheritance (HP:0001427)	3.94133166
6	Abnormality of cells of the erythroid lineage (HP:0012130)	3.92103460
7	Progressive macrocephaly (HP:0004481)	3.79580196
8	Increased CSF lactate (HP:0002490)	3.71879439
9	Abnormality of midbrain morphology (HP:0002418)	3.67839906
10	Molar tooth sign on MRI (HP:0002419)	3.67839906
11	3-Methylglutaconic aciduria (HP:0003535)	3.60479046
12	Abnormal number of erythroid precursors (HP:0012131)	3.44547464
13	Pancreatic cysts (HP:0001737)	3.43047746
14	Pancreatic fibrosis (HP:0100732)	3.38984651
15	Hepatocellular necrosis (HP:0001404)	3.32017663
16	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.28481491
17	Macrocytic anemia (HP:0001972)	3.26759390
18	Nephronophthisis (HP:0000090)	3.21610768
19	Hepatic necrosis (HP:0002605)	3.14403055
20	Colon cancer (HP:0003003)	3.00684957
21	Congenital stationary night blindness (HP:0007642)	2.95756891
22	Increased hepatocellular lipid droplets (HP:0006565)	2.91333262
23	Abnormal rod and cone electroretinograms (HP:0008323)	2.90813419
24	Optic disc pallor (HP:0000543)	2.89023820
25	Cerebral edema (HP:0002181)	2.86756191
26	True hermaphroditism (HP:0010459)	2.81279264
27	Hyperglycinemia (HP:0002154)	2.78287335
28	Abolished electroretinogram (ERG) (HP:0000550)	2.76567539
29	Medial flaring of the eyebrow (HP:0010747)	2.71953859
30	Abnormality of the renal medulla (HP:0100957)	2.68898346
31	Lipid accumulation in hepatocytes (HP:0006561)	2.68092159
32	Increased serum lactate (HP:0002151)	2.66137668
33	Methylmalonic acidemia (HP:0002912)	2.65021246
34	Cystic liver disease (HP:0006706)	2.55205852
35	Pendular nystagmus (HP:0012043)	2.54582559
36	Pallor (HP:0000980)	2.51547698
37	Abnormality of the renal cortex (HP:0011035)	2.45996453
38	Attenuation of retinal blood vessels (HP:0007843)	2.42015254
39	Lactic acidosis (HP:0003128)	2.39177454
40	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.37769729
41	Abnormality of alanine metabolism (HP:0010916)	2.37769729
42	Hyperalaninemia (HP:0003348)	2.37769729
43	Abnormality of the labia minora (HP:0012880)	2.35765539
44	Type II lissencephaly (HP:0007260)	2.31062990
45	Absent thumb (HP:0009777)	2.29554466
46	Increased intramyocellular lipid droplets (HP:0012240)	2.28918920
47	Methylmalonic aciduria (HP:0012120)	2.28786626
48	Absent/shortened dynein arms (HP:0200106)	2.26919968
49	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.26919968
50	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.23081571
51	Abnormal drinking behavior (HP:0030082)	2.22227918
52	Polydipsia (HP:0001959)	2.22227918
53	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.22215758
54	Renal Fanconi syndrome (HP:0001994)	2.19283047
55	Decreased central vision (HP:0007663)	2.18757512
56	Leukodystrophy (HP:0002415)	2.13377974
57	Gait imbalance (HP:0002141)	2.08632978
58	Lethargy (HP:0001254)	2.07738185
59	Respiratory failure (HP:0002878)	2.05926274
60	Constricted visual fields (HP:0001133)	2.04870777
61	Triphalangeal thumb (HP:0001199)	2.01861994
62	Abnormal ciliary motility (HP:0012262)	2.01508436
63	Congenital primary aphakia (HP:0007707)	2.01426197
64	Sclerocornea (HP:0000647)	1.99248308
65	Polyuria (HP:0000103)	1.97806828
66	Type 2 muscle fiber atrophy (HP:0003554)	1.96805108
67	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.96602507
68	Congenital, generalized hypertrichosis (HP:0004540)	1.96486961
69	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.95432599
70	Renal cortical cysts (HP:0000803)	1.94663532
71	Abnormal respiratory epithelium morphology (HP:0012253)	1.94637663
72	Abnormal respiratory motile cilium morphology (HP:0005938)	1.94637663
73	Increased corneal curvature (HP:0100692)	1.94464644
74	Keratoconus (HP:0000563)	1.94464644
75	Abnormal hemoglobin (HP:0011902)	1.90773521
76	Myokymia (HP:0002411)	1.89670224
77	Nephrogenic diabetes insipidus (HP:0009806)	1.89349025
78	Hypoplasia of the radius (HP:0002984)	1.88365448
79	Postaxial foot polydactyly (HP:0001830)	1.87783790
80	Exercise intolerance (HP:0003546)	1.86863057
81	Asplenia (HP:0001746)	1.86578337
82	Exertional dyspnea (HP:0002875)	1.84728818
83	Abnormality of DNA repair (HP:0003254)	1.83177980
84	Increased muscle lipid content (HP:0009058)	1.81558634
85	Bile duct proliferation (HP:0001408)	1.80159313
86	Abnormal biliary tract physiology (HP:0012439)	1.80159313
87	Chronic hepatic failure (HP:0100626)	1.79244761
88	Delayed CNS myelination (HP:0002188)	1.79010569
89	Abnormality of urine glucose concentration (HP:0011016)	1.78594180
90	Glycosuria (HP:0003076)	1.78594180
91	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.78284699
92	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.78284699
93	Congenital hepatic fibrosis (HP:0002612)	1.77242002
94	Anencephaly (HP:0002323)	1.76614171
95	Tubular atrophy (HP:0000092)	1.75522288
96	Agitation (HP:0000713)	1.74536266
97	Adrenal hypoplasia (HP:0000835)	1.74498081
98	Abnormal respiratory motile cilium physiology (HP:0012261)	1.73754081
99	Abnormality of serum amino acid levels (HP:0003112)	1.71633278
100	Chorioretinal atrophy (HP:0000533)	1.68572424

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.39214506
2	STK16	3.06948384
3	WNK4	3.06623900
4	ZAK	2.95693028
5	FRK	2.91104852
6	TLK1	2.68805585
7	ADRBK2	2.63691904
8	TXK	2.60502664
9	NUAK1	2.49174213
10	BCKDK	2.23648268
11	GRK1	2.22653044
12	TAOK3	2.22167896
13	PINK1	2.07586821
14	CDK19	2.00214935
15	DYRK2	1.71110806
16	OXSR1	1.70229255
17	STK39	1.61971517
18	BMPR1B	1.58848575
19	FES	1.52999120
20	TEC	1.50086403
21	TIE1	1.48169517
22	NME2	1.46965309
23	KIT	1.44486178
24	INSRR	1.31296943
25	VRK2	1.27722080
26	NME1	1.17791343
27	ITK	1.17251383
28	WNK3	1.14680176
29	PASK	1.13426377
30	MAP3K11	1.05145037
31	PRKCG	1.01860363
32	CAMKK2	1.00639357
33	MAP4K1	0.99456652
34	IKBKB	0.97547025
35	PHKG1	0.95565365
36	PHKG2	0.95565365
37	PDK2	0.95486625
38	MAP2K6	0.88852251
39	MAPK13	0.87886459
40	TRIM28	0.84792813
41	RPS6KA5	0.82095754
42	BTK	0.82019838
43	PRKCQ	0.81976886
44	ADRBK1	0.80323967
45	MUSK	0.78098329
46	VRK1	0.76172830
47	EPHA4	0.75039425
48	CSNK1G3	0.72905374
49	CSNK1G2	0.71347694
50	MKNK1	0.70476506
51	MKNK2	0.69875035
52	CAMK1	0.68583169
53	PLK4	0.66283058
54	CDK8	0.62268904
55	PAK3	0.61581636
56	TGFBR1	0.61513740
57	CSF1R	0.60431150
58	CSNK2A2	0.59941287
59	TRPM7	0.59682700
60	BCR	0.58785094
61	CSNK1G1	0.58624871
62	PRKACA	0.58106903
63	SYK	0.56620027
64	PRKCE	0.56298845
65	CSNK1A1	0.56024805
66	MINK1	0.55392643
67	EIF2AK3	0.54703567
68	ATR	0.53744423
69	TYRO3	0.53740209
70	RPS6KA6	0.53145912
71	CSNK1A1L	0.52672963
72	ILK	0.52577025
73	MAP3K4	0.51815871
74	DAPK2	0.50906813
75	NEK1	0.50702966
76	LYN	0.50089841
77	MATK	0.46638576
78	CSNK2A1	0.46223688
79	CSNK1E	0.46222524
80	ABL2	0.46144372
81	OBSCN	0.45730280
82	MARK3	0.44436570
83	STK11	0.44273380
84	PRKCH	0.44254074
85	MAP3K12	0.43787248
86	PRKCA	0.43371486
87	LRRK2	0.43282315
88	RPS6KB2	0.41809293
89	CAMK2A	0.41801096
90	FLT3	0.41254126
91	MAP2K2	0.41101593
92	PLK3	0.40054697
93	PIK3CG	0.39838715
94	WNK1	0.39665152
95	TAF1	0.39422293
96	LCK	0.39296564
97	PRKCZ	0.38648693
98	MAPKAPK3	0.37839060
99	PLK1	0.37278271
100	PRKCD	0.37218044

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.26944824
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.72688914
3	Parkinsons disease_Homo sapiens_hsa05012	3.00860064
4	Protein export_Homo sapiens_hsa03060	2.89937365
5	Asthma_Homo sapiens_hsa05310	2.87696675
6	Allograft rejection_Homo sapiens_hsa05330	2.26182663
7	RNA polymerase_Homo sapiens_hsa03020	2.25818637
8	Proteasome_Homo sapiens_hsa03050	2.21768317
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.21569150
10	Homologous recombination_Homo sapiens_hsa03440	2.15240445
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.02181556
12	Linoleic acid metabolism_Homo sapiens_hsa00591	2.02111788
13	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.00353976
14	Huntingtons disease_Homo sapiens_hsa05016	1.98222376
15	Type I diabetes mellitus_Homo sapiens_hsa04940	1.93801589
16	Alzheimers disease_Homo sapiens_hsa05010	1.91335673
17	Phototransduction_Homo sapiens_hsa04744	1.90803764
18	Cardiac muscle contraction_Homo sapiens_hsa04260	1.90536477
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.85371166
20	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.81890430
21	Graft-versus-host disease_Homo sapiens_hsa05332	1.74479191
22	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.71821506
23	RNA degradation_Homo sapiens_hsa03018	1.65179002
24	Basal transcription factors_Homo sapiens_hsa03022	1.55304298
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.51196080
26	One carbon pool by folate_Homo sapiens_hsa00670	1.49313138
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.47186646
28	Mismatch repair_Homo sapiens_hsa03430	1.35289373
29	Pyrimidine metabolism_Homo sapiens_hsa00240	1.28724112
30	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.28577801
31	Butanoate metabolism_Homo sapiens_hsa00650	1.26697186
32	Sulfur relay system_Homo sapiens_hsa04122	1.25457451
33	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.18573214
34	Nucleotide excision repair_Homo sapiens_hsa03420	1.18215780
35	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.10165456
36	Tryptophan metabolism_Homo sapiens_hsa00380	1.07951456
37	Propanoate metabolism_Homo sapiens_hsa00640	1.07184244
38	Ether lipid metabolism_Homo sapiens_hsa00565	1.05513431
39	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.04041317
40	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.99897756
41	Non-homologous end-joining_Homo sapiens_hsa03450	0.96627081
42	Purine metabolism_Homo sapiens_hsa00230	0.94340183
43	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.94022947
44	Peroxisome_Homo sapiens_hsa04146	0.92912911
45	Nitrogen metabolism_Homo sapiens_hsa00910	0.92105378
46	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.90881358
47	DNA replication_Homo sapiens_hsa03030	0.88429064
48	Base excision repair_Homo sapiens_hsa03410	0.88363655
49	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.85746410
50	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.85407999
51	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.83663990
52	Caffeine metabolism_Homo sapiens_hsa00232	0.81767714
53	Olfactory transduction_Homo sapiens_hsa04740	0.81210101
54	Nicotine addiction_Homo sapiens_hsa05033	0.77353825
55	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.75608290
56	Fatty acid elongation_Homo sapiens_hsa00062	0.75290077
57	Rheumatoid arthritis_Homo sapiens_hsa05323	0.74314150
58	RNA transport_Homo sapiens_hsa03013	0.72696298
59	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.71047023
60	Sulfur metabolism_Homo sapiens_hsa00920	0.69403621
61	Collecting duct acid secretion_Homo sapiens_hsa04966	0.67332489
62	Metabolic pathways_Homo sapiens_hsa01100	0.67100931
63	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.65807831
64	Fat digestion and absorption_Homo sapiens_hsa04975	0.64376236
65	Retinol metabolism_Homo sapiens_hsa00830	0.62246515
66	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.62108240
67	Chemical carcinogenesis_Homo sapiens_hsa05204	0.60157751
68	Regulation of autophagy_Homo sapiens_hsa04140	0.57933760
69	Primary immunodeficiency_Homo sapiens_hsa05340	0.57161484
70	Antigen processing and presentation_Homo sapiens_hsa04612	0.57133997
71	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.55628036
72	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.54922252
73	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.54600466
74	Morphine addiction_Homo sapiens_hsa05032	0.50125972
75	Spliceosome_Homo sapiens_hsa03040	0.48930919
76	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.48282102
77	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.46549199
78	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.45979765
79	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.45601126
80	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.45562928
81	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.42162087
82	Salivary secretion_Homo sapiens_hsa04970	0.41986447
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39380731
84	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.38755974
85	beta-Alanine metabolism_Homo sapiens_hsa00410	0.37042829
86	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.36865670
87	Selenocompound metabolism_Homo sapiens_hsa00450	0.34977883
88	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.33539634
89	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.31915129
90	Insulin secretion_Homo sapiens_hsa04911	0.31880298
91	Taste transduction_Homo sapiens_hsa04742	0.31274413
92	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.29559067
93	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.29287276
94	Serotonergic synapse_Homo sapiens_hsa04726	0.29131266
95	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.28406191
96	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.27942717
97	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.27511619
98	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.27504599
99	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.26832072
100	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.25303620

RPL5P17

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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