ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein neddylation (GO:0045116)	5.41050405
2	ATP synthesis coupled proton transport (GO:0015986)	5.27980734
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.27980734
4	regulation of sarcomere organization (GO:0060297)	5.06682304
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.95471745
6	organelle disassembly (GO:1903008)	4.64664853
7	ribonucleoprotein complex disassembly (GO:0032988)	4.31408775
8	water-soluble vitamin biosynthetic process (GO:0042364)	4.26122287
9	DNA deamination (GO:0045006)	4.26080987
10	ribosomal large subunit biogenesis (GO:0042273)	4.20776529
11	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.17774593
12	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.17774593
13	NADH dehydrogenase complex assembly (GO:0010257)	4.17774593
14	chaperone-mediated protein transport (GO:0072321)	4.02610870
15	protein complex biogenesis (GO:0070271)	4.02100372
16	ribosomal small subunit assembly (GO:0000028)	4.01711965
17	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.95920848
18	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.86972162
19	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.79737340
20	termination of RNA polymerase III transcription (GO:0006386)	3.79737340
21	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.79294271
22	mitochondrial respiratory chain complex assembly (GO:0033108)	3.70816755
23	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.66286539
24	viral transcription (GO:0019083)	3.58125893
25	translational termination (GO:0006415)	3.55562226
26	proteasome assembly (GO:0043248)	3.53988794
27	behavioral response to nicotine (GO:0035095)	3.52293830
28	respiratory electron transport chain (GO:0022904)	3.48475311
29	translational elongation (GO:0006414)	3.47805639
30	electron transport chain (GO:0022900)	3.47157816
31	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.47118611
32	negative regulation of nitric-oxide synthase activity (GO:0051001)	3.43460229
33	regulation of action potential (GO:0098900)	3.42528486
34	cotranslational protein targeting to membrane (GO:0006613)	3.41340201
35	protein targeting to ER (GO:0045047)	3.35192026
36	maturation of SSU-rRNA (GO:0030490)	3.35182142
37	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.34093364
38	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.34093364
39	respiratory chain complex IV assembly (GO:0008535)	3.27646155
40	protein polyglutamylation (GO:0018095)	3.21978607
41	protein localization to endoplasmic reticulum (GO:0070972)	3.20097118
42	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.19780784
43	cullin deneddylation (GO:0010388)	3.13420009
44	GTP biosynthetic process (GO:0006183)	3.11497061
45	phenol-containing compound catabolic process (GO:0019336)	3.09863770
46	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.02071597
47	somite development (GO:0061053)	2.98164976
48	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.97556230
49	protein deneddylation (GO:0000338)	2.95486824
50	translation (GO:0006412)	2.94066510
51	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.93148707
52	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.91480710
53	nonmotile primary cilium assembly (GO:0035058)	2.88910637
54	ATP biosynthetic process (GO:0006754)	2.87354490
55	hydrogen ion transmembrane transport (GO:1902600)	2.87048895
56	L-fucose catabolic process (GO:0042355)	2.85648204
57	fucose catabolic process (GO:0019317)	2.85648204
58	L-fucose metabolic process (GO:0042354)	2.85648204
59	preassembly of GPI anchor in ER membrane (GO:0016254)	2.82468845
60	cytochrome complex assembly (GO:0017004)	2.81526122
61	proton transport (GO:0015992)	2.79973089
62	aldehyde catabolic process (GO:0046185)	2.79430146
63	response to pheromone (GO:0019236)	2.79183133
64	regulation of skeletal muscle contraction (GO:0014819)	2.79057332
65	hydrogen transport (GO:0006818)	2.78977281
66	positive regulation of protein homodimerization activity (GO:0090073)	2.76037655
67	tRNA processing (GO:0008033)	2.73935957
68	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.72850201
69	protein localization to cilium (GO:0061512)	2.72745727
70	rRNA modification (GO:0000154)	2.70445761
71	sequestering of actin monomers (GO:0042989)	2.69896137
72	negative regulation of muscle hypertrophy (GO:0014741)	2.68086046
73	DNA damage response, detection of DNA damage (GO:0042769)	2.67469429
74	regulation of cellular amino acid metabolic process (GO:0006521)	2.65934805
75	cellular protein complex disassembly (GO:0043624)	2.65922161
76	DNA double-strand break processing (GO:0000729)	2.63261511
77	translational initiation (GO:0006413)	2.62087037
78	iron-sulfur cluster assembly (GO:0016226)	2.59327278
79	metallo-sulfur cluster assembly (GO:0031163)	2.59327278
80	cellular component biogenesis (GO:0044085)	2.58812161
81	GPI anchor metabolic process (GO:0006505)	2.55434377
82	protein-cofactor linkage (GO:0018065)	2.55216962
83	base-excision repair, AP site formation (GO:0006285)	2.53663374
84	epithelial cilium movement (GO:0003351)	2.53386752
85	piRNA metabolic process (GO:0034587)	2.50863607
86	negative regulation of heart rate (GO:0010459)	2.49632702
87	platelet dense granule organization (GO:0060155)	2.48261267
88	kynurenine metabolic process (GO:0070189)	2.47664508
89	maturation of 5.8S rRNA (GO:0000460)	2.47614688
90	substrate-independent telencephalic tangential migration (GO:0021826)	2.47292009
91	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.47292009
92	viral life cycle (GO:0019058)	2.47008274
93	intracellular protein transmembrane import (GO:0044743)	2.46256769
94	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.45052808
95	regulation of isotype switching to IgG isotypes (GO:0048302)	2.44167771
96	negative regulation of mast cell activation (GO:0033004)	2.43601005
97	regulation of cilium movement (GO:0003352)	2.41147731
98	tRNA metabolic process (GO:0006399)	2.40064424
99	DNA demethylation (GO:0080111)	2.39839337
100	UTP biosynthetic process (GO:0006228)	2.39304375

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.85000955
2	VDR_22108803_ChIP-Seq_LS180_Human	3.74810267
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.51126590
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.42232573
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.35702687
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.00656573
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.96041559
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.89471742
9	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.51954763
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.48637269
11	EWS_26573619_Chip-Seq_HEK293_Human	2.41529454
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.41008857
13	ELK1_19687146_ChIP-ChIP_HELA_Human	2.39899342
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.21174992
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.17051047
16	FUS_26573619_Chip-Seq_HEK293_Human	2.16426478
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.15106882
18	TAF15_26573619_Chip-Seq_HEK293_Human	2.09656530
19	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.09438954
20	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.02103342
21	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.00071371
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.96126925
23	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.82641642
24	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.77573295
25	P300_19829295_ChIP-Seq_ESCs_Human	1.77434454
26	FOXP3_21729870_ChIP-Seq_TREG_Human	1.77165739
27	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.73973690
28	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.73333662
29	IRF1_19129219_ChIP-ChIP_H3396_Human	1.67500651
30	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.65247517
31	ER_23166858_ChIP-Seq_MCF-7_Human	1.62838094
32	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.62067492
33	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.59543954
34	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.55765671
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.52735923
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.51034836
37	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.50791761
38	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.50520926
39	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.45546322
40	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.39340525
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.38402809
42	GBX2_23144817_ChIP-Seq_PC3_Human	1.37887313
43	MYC_18940864_ChIP-ChIP_HL60_Human	1.36931682
44	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.36043375
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.33236320
46	NANOG_19829295_ChIP-Seq_ESCs_Human	1.33236320
47	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.32085946
48	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.31091234
49	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.29893117
50	CBP_20019798_ChIP-Seq_JUKART_Human	1.29893117
51	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.26420976
52	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.25920194
53	RNF2_27304074_Chip-Seq_NSC_Mouse	1.23850210
54	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.21737689
55	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.21737689
56	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.21553130
57	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.20322227
58	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.19654279
59	NCOR_22424771_ChIP-Seq_293T_Human	1.18921463
60	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.17202859
61	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.17091534
62	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.15074383
63	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.13634799
64	AR_20517297_ChIP-Seq_VCAP_Human	1.13489476
65	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.13239352
66	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.11971968
67	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.09592382
68	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.09527668
69	TTF2_22483619_ChIP-Seq_HELA_Human	1.07957110
70	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.07438627
71	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.06791047
72	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.06625639
73	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02264767
74	MYC_19829295_ChIP-Seq_ESCs_Human	1.02131644
75	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01805812
76	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.01097478
77	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.00969680
78	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.00162011
79	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.99051547
80	AR_25329375_ChIP-Seq_VCAP_Human	0.98621412
81	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.97726637
82	TCF4_22108803_ChIP-Seq_LS180_Human	0.97416392
83	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.95329485
84	ERG_20517297_ChIP-Seq_VCAP_Human	0.94606102
85	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.94150096
86	BCAT_22108803_ChIP-Seq_LS180_Human	0.93836135
87	P53_22387025_ChIP-Seq_ESCs_Mouse	0.93220832
88	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.92970308
89	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.92970308
90	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.92095743
91	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.92026139
92	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.91302204
93	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.90578567
94	SMAD4_21799915_ChIP-Seq_A2780_Human	0.89974847
95	RUNX2_22187159_ChIP-Seq_PCA_Human	0.89686562
96	GABP_19822575_ChIP-Seq_HepG2_Human	0.89507893
97	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.89018303
98	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.88788114
99	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.88395932
100	TAF2_19829295_ChIP-Seq_ESCs_Human	0.88382469

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.76931688
2	MP0002102_abnormal_ear_morphology	3.68354701
3	MP0006072_abnormal_retinal_apoptosis	2.77511503
4	MP0008789_abnormal_olfactory_epithelium	2.68567444
5	MP0008877_abnormal_DNA_methylation	2.30963922
6	MP0009379_abnormal_foot_pigmentation	2.28816854
7	MP0004142_abnormal_muscle_tone	2.19269728
8	MP0001529_abnormal_vocalization	2.18579570
9	MP0005551_abnormal_eye_electrophysiolog	2.08731212
10	MP0008058_abnormal_DNA_repair	2.07372422
11	MP0005499_abnormal_olfactory_system	2.06039057
12	MP0005394_taste/olfaction_phenotype	2.06039057
13	MP0003880_abnormal_central_pattern	2.05862277
14	MP0002837_dystrophic_cardiac_calcinosis	2.04533029
15	MP0003787_abnormal_imprinting	2.03049172
16	MP0004145_abnormal_muscle_electrophysio	2.02960785
17	MP0008872_abnormal_physiological_respon	1.98127669
18	MP0008875_abnormal_xenobiotic_pharmacok	1.97762322
19	MP0002234_abnormal_pharynx_morphology	1.95650806
20	MP0003950_abnormal_plasma_membrane	1.90499152
21	MP0005646_abnormal_pituitary_gland	1.89984185
22	MP0002736_abnormal_nociception_after	1.83341193
23	MP0002822_catalepsy	1.79269012
24	MP0001835_abnormal_antigen_presentation	1.79239415
25	MP0005645_abnormal_hypothalamus_physiol	1.75478335
26	MP0005253_abnormal_eye_physiology	1.71733493
27	MP0001968_abnormal_touch/_nociception	1.71410564
28	MP0003011_delayed_dark_adaptation	1.65448400
29	MP0001293_anophthalmia	1.61496282
30	MP0003186_abnormal_redox_activity	1.56445982
31	MP0003806_abnormal_nucleotide_metabolis	1.55638581
32	MP0002163_abnormal_gland_morphology	1.54257231
33	MP0006276_abnormal_autonomic_nervous	1.53302422
34	MP0004084_abnormal_cardiac_muscle	1.50171451
35	MP0005084_abnormal_gallbladder_morpholo	1.48690581
36	MP0008995_early_reproductive_senescence	1.48280283
37	MP0002272_abnormal_nervous_system	1.48051146
38	MP0001873_stomach_inflammation	1.47007207
39	MP0004885_abnormal_endolymph	1.46960946
40	MP0003195_calcinosis	1.40143082
41	MP0003646_muscle_fatigue	1.31417309
42	MP0001486_abnormal_startle_reflex	1.30278926
43	MP0005389_reproductive_system_phenotype	1.28662673
44	MP0001905_abnormal_dopamine_level	1.28528950
45	MP0003122_maternal_imprinting	1.26084151
46	MP0001984_abnormal_olfaction	1.25764651
47	MP0005075_abnormal_melanosome_morpholog	1.24873728
48	MP0001986_abnormal_taste_sensitivity	1.24800282
49	MP0002160_abnormal_reproductive_system	1.21614342
50	MP0000049_abnormal_middle_ear	1.20695881
51	MP0003786_premature_aging	1.17226601
52	MP0000631_abnormal_neuroendocrine_gland	1.16157098
53	MP0001919_abnormal_reproductive_system	1.15981105
54	MP0009046_muscle_twitch	1.15224608
55	MP0001485_abnormal_pinna_reflex	1.14349433
56	MP0000372_irregular_coat_pigmentation	1.10742582
57	MP0009745_abnormal_behavioral_response	1.10295220
58	MP0008775_abnormal_heart_ventricle	1.08118749
59	MP0004147_increased_porphyrin_level	1.07994773
60	MP0005379_endocrine/exocrine_gland_phen	1.04567333
61	MP0003567_abnormal_fetal_cardiomyocyte	1.02807433
62	MP0001501_abnormal_sleep_pattern	0.99258288
63	MP0001440_abnormal_grooming_behavior	0.99189238
64	MP0006036_abnormal_mitochondrial_physio	0.99033713
65	MP0002282_abnormal_trachea_morphology	0.98131142
66	MP0001970_abnormal_pain_threshold	0.98117483
67	MP0005195_abnormal_posterior_eye	0.96790658
68	MP0001764_abnormal_homeostasis	0.93959195
69	MP0002572_abnormal_emotion/affect_behav	0.92058179
70	MP0002557_abnormal_social/conspecific_i	0.90377471
71	MP0000427_abnormal_hair_cycle	0.89432739
72	MP0009697_abnormal_copulation	0.88718168
73	MP0002638_abnormal_pupillary_reflex	0.88619733
74	MP0002733_abnormal_thermal_nociception	0.87581963
75	MP0002938_white_spotting	0.87221396
76	MP0003121_genomic_imprinting	0.85866509
77	MP0005391_vision/eye_phenotype	0.84540844
78	MP0002138_abnormal_hepatobiliary_system	0.84230062
79	MP0005671_abnormal_response_to	0.83961954
80	MP0002752_abnormal_somatic_nervous	0.83403367
81	MP0004215_abnormal_myocardial_fiber	0.82631149
82	MP0002751_abnormal_autonomic_nervous	0.81868039
83	MP0002095_abnormal_skin_pigmentation	0.81210315
84	MP0003718_maternal_effect	0.79444872
85	MP0000749_muscle_degeneration	0.79000101
86	MP0002876_abnormal_thyroid_physiology	0.76916106
87	MP0005085_abnormal_gallbladder_physiolo	0.76384994
88	MP0000778_abnormal_nervous_system	0.75968130
89	MP0002184_abnormal_innervation	0.73525841
90	MP0003119_abnormal_digestive_system	0.71914502
91	MP0002735_abnormal_chemical_nociception	0.71233607
92	MP0002653_abnormal_ependyma_morphology	0.70758287
93	MP0003252_abnormal_bile_duct	0.69913308
94	MP0000230_abnormal_systemic_arterial	0.69581602
95	MP0009764_decreased_sensitivity_to	0.69548223
96	MP0003283_abnormal_digestive_organ	0.69080230
97	MP0002210_abnormal_sex_determination	0.68795773
98	MP0006035_abnormal_mitochondrial_morpho	0.66817932
99	MP0000026_abnormal_inner_ear	0.65288844
100	MP0000516_abnormal_urinary_system	0.64983837

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.52642955
2	Acute encephalopathy (HP:0006846)	4.25078401
3	Mitochondrial inheritance (HP:0001427)	4.19903054
4	Renal cortical cysts (HP:0000803)	3.97701300
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.95723845
6	Hepatocellular necrosis (HP:0001404)	3.95344212
7	Increased CSF lactate (HP:0002490)	3.89574624
8	Progressive macrocephaly (HP:0004481)	3.84426784
9	Hepatic necrosis (HP:0002605)	3.51490587
10	Increased hepatocellular lipid droplets (HP:0006565)	3.42413019
11	Molar tooth sign on MRI (HP:0002419)	3.41094237
12	Abnormality of midbrain morphology (HP:0002418)	3.41094237
13	Abolished electroretinogram (ERG) (HP:0000550)	3.23943697
14	3-Methylglutaconic aciduria (HP:0003535)	3.22712338
15	Pancreatic cysts (HP:0001737)	3.21606439
16	Abnormality of the renal cortex (HP:0011035)	3.17723760
17	Nephronophthisis (HP:0000090)	3.15499523
18	Lipid accumulation in hepatocytes (HP:0006561)	3.10522762
19	Medial flaring of the eyebrow (HP:0010747)	3.09731002
20	Cerebral edema (HP:0002181)	3.09486985
21	Congenital stationary night blindness (HP:0007642)	3.02785795
22	Calf muscle hypertrophy (HP:0008981)	2.96950401
23	Methylmalonic acidemia (HP:0002912)	2.92597602
24	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.89239501
25	Hyperglycinemia (HP:0002154)	2.87169789
26	Congenital, generalized hypertrichosis (HP:0004540)	2.85931221
27	Muscle hypertrophy of the lower extremities (HP:0008968)	2.81970088
28	Optic disc pallor (HP:0000543)	2.76775903
29	Pancreatic fibrosis (HP:0100732)	2.62758507
30	Abnormal rod and cone electroretinograms (HP:0008323)	2.57767375
31	Abnormality of the renal medulla (HP:0100957)	2.56906919
32	Renal Fanconi syndrome (HP:0001994)	2.54589907
33	Increased serum lactate (HP:0002151)	2.51982662
34	Pendular nystagmus (HP:0012043)	2.45283566
35	True hermaphroditism (HP:0010459)	2.43784416
36	Type 2 muscle fiber atrophy (HP:0003554)	2.43599281
37	Myotonia (HP:0002486)	2.39867266
38	Attenuation of retinal blood vessels (HP:0007843)	2.39251553
39	Lactic acidosis (HP:0003128)	2.36953533
40	Colon cancer (HP:0003003)	2.35943587
41	Increased intramyocellular lipid droplets (HP:0012240)	2.35587849
42	Constricted visual fields (HP:0001133)	2.32347827
43	Increased serum pyruvate (HP:0003542)	2.26924149
44	Increased corneal curvature (HP:0100692)	2.25963299
45	Keratoconus (HP:0000563)	2.25963299
46	Methylmalonic aciduria (HP:0012120)	2.24512595
47	Gait imbalance (HP:0002141)	2.23094503
48	Congenital primary aphakia (HP:0007707)	2.21255319
49	Nephrogenic diabetes insipidus (HP:0009806)	2.15821624
50	Brushfield spots (HP:0001088)	2.15665382
51	Exertional dyspnea (HP:0002875)	2.11668735
52	Hypoplasia of the thymus (HP:0000778)	2.10344492
53	Poor suck (HP:0002033)	2.10240433
54	Leukodystrophy (HP:0002415)	2.10174162
55	Abnormality of serum amino acid levels (HP:0003112)	2.08153197
56	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.08066232
57	Abnormality of alanine metabolism (HP:0010916)	2.08066232
58	Hyperalaninemia (HP:0003348)	2.08066232
59	Exercise-induced muscle cramps (HP:0003710)	2.08065139
60	Sclerocornea (HP:0000647)	2.05299604
61	Lethargy (HP:0001254)	2.04952871
62	Macrocytic anemia (HP:0001972)	2.02665930
63	Respiratory failure (HP:0002878)	2.02061532
64	CNS demyelination (HP:0007305)	2.01585685
65	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.00750392
66	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.00750392
67	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.98169982
68	Hypomagnesemia (HP:0002917)	1.97274375
69	Abnormality of the labia minora (HP:0012880)	1.96012866
70	Abnormality of cells of the erythroid lineage (HP:0012130)	1.95727140
71	Abnormality of placental membranes (HP:0011409)	1.94842475
72	Amniotic constriction ring (HP:0009775)	1.94842475
73	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.93879601
74	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.91855592
75	Absent/shortened dynein arms (HP:0200106)	1.91855592
76	Abnormal respiratory epithelium morphology (HP:0012253)	1.91148908
77	Abnormal respiratory motile cilium morphology (HP:0005938)	1.91148908
78	Muscle fiber atrophy (HP:0100295)	1.90360708
79	Type II lissencephaly (HP:0007260)	1.90157568
80	Exercise intolerance (HP:0003546)	1.88010122
81	Reticulocytopenia (HP:0001896)	1.85453212
82	Respiratory difficulties (HP:0002880)	1.84764022
83	Type I transferrin isoform profile (HP:0003642)	1.83923941
84	Stenosis of the external auditory canal (HP:0000402)	1.83904662
85	Septo-optic dysplasia (HP:0100842)	1.83673473
86	IgG deficiency (HP:0004315)	1.82810553
87	Hyperglycinuria (HP:0003108)	1.82218952
88	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.81276726
89	Increased muscle lipid content (HP:0009058)	1.78966933
90	Abnormality of the left ventricular outflow tract (HP:0011103)	1.77793859
91	Subaortic stenosis (HP:0001682)	1.77793859
92	Glycosuria (HP:0003076)	1.77669162
93	Abnormality of urine glucose concentration (HP:0011016)	1.77669162
94	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.77495650
95	Abnormal number of erythroid precursors (HP:0012131)	1.77104491
96	Abnormality of glycine metabolism (HP:0010895)	1.76614907
97	Abnormality of serine family amino acid metabolism (HP:0010894)	1.76614907
98	Abnormality of the prostate (HP:0008775)	1.76070980
99	Bony spicule pigmentary retinopathy (HP:0007737)	1.73110357
100	Asplenia (HP:0001746)	1.69875664

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.76035999
2	TLK1	2.70549088
3	TRIM28	2.58605601
4	NUAK1	2.53288884
5	FRK	2.31818542
6	EIF2AK3	2.27639172
7	STK16	2.15750473
8	MAPKAPK5	2.10954731
9	CDK19	2.10087952
10	ZAK	2.04003277
11	WNK3	2.02396477
12	GRK1	2.00122969
13	TXK	1.73945099
14	MAP3K4	1.73317803
15	CDK8	1.69356710
16	BCKDK	1.68691384
17	TIE1	1.67728288
18	ADRBK2	1.66430829
19	BMPR1B	1.55155591
20	CSNK1G2	1.54759017
21	VRK1	1.54574319
22	BCR	1.54503280
23	SRPK1	1.50583488
24	VRK2	1.45356449
25	CAMKK2	1.44114646
26	DYRK2	1.40137654
27	CSNK1G3	1.38615845
28	MUSK	1.38610473
29	EIF2AK1	1.37101039
30	TEC	1.31554535
31	PINK1	1.31147998
32	MAPK13	1.28160565
33	CCNB1	1.24912271
34	TAOK3	1.23551113
35	PLK4	1.22927364
36	MAP3K12	1.21316489
37	CSNK1A1L	1.19944860
38	ERBB3	1.14586304
39	INSRR	1.12024227
40	OXSR1	1.11468820
41	WNK4	1.11124268
42	CSNK1G1	1.05704163
43	MST4	1.04244563
44	MAP2K7	0.96005752
45	MKNK1	0.93407585
46	PLK3	0.91826900
47	TNIK	0.89741621
48	EPHA4	0.88251702
49	PRKCG	0.83386741
50	RPS6KA4	0.81286052
51	DAPK1	0.79813754
52	PLK2	0.78097774
53	TSSK6	0.77073788
54	NME1	0.76699209
55	DYRK3	0.74763756
56	FLT3	0.73491919
57	KIT	0.71679751
58	PIK3CG	0.71152673
59	EIF2AK2	0.66495348
60	ACVR1B	0.66290044
61	SYK	0.64328838
62	PRKCE	0.63902931
63	IKBKB	0.63692625
64	ITK	0.62904398
65	PAK3	0.62472768
66	MAPKAPK3	0.61230262
67	DAPK2	0.61198569
68	RPS6KA5	0.61001743
69	BMPR2	0.60733795
70	TGFBR1	0.60289128
71	PASK	0.60206475
72	MYLK	0.60148655
73	PHKG2	0.55136808
74	PHKG1	0.55136808
75	STK38L	0.55103404
76	PAK6	0.54592423
77	CAMK1	0.54032687
78	OBSCN	0.52804821
79	IGF1R	0.52339610
80	CSNK1A1	0.52213590
81	MINK1	0.52027646
82	MARK1	0.51745661
83	PBK	0.50418097
84	PDK2	0.49378676
85	PIK3CA	0.48051432
86	PRKACB	0.45927730
87	PRKACA	0.44353368
88	CSNK2A2	0.44111121
89	ATR	0.42970483
90	STK39	0.42947073
91	DAPK3	0.42716565
92	ADRBK1	0.42633680
93	CAMK2A	0.42625278
94	CSNK1D	0.42125996
95	TAF1	0.41960406
96	CSNK2A1	0.41431123
97	AURKB	0.40745088
98	CSF1R	0.38792872
99	CDK3	0.38366884
100	GRK5	0.36636988

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.64896583
2	Asthma_Homo sapiens_hsa05310	3.53613551
3	Ribosome_Homo sapiens_hsa03010	3.29790173
4	Protein export_Homo sapiens_hsa03060	3.27182013
5	Proteasome_Homo sapiens_hsa03050	3.27063580
6	Parkinsons disease_Homo sapiens_hsa05012	2.97031359
7	Allograft rejection_Homo sapiens_hsa05330	2.57581149
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.42928941
9	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.33921370
10	RNA polymerase_Homo sapiens_hsa03020	2.32977235
11	Type I diabetes mellitus_Homo sapiens_hsa04940	2.20865985
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.08579148
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.98096986
14	Graft-versus-host disease_Homo sapiens_hsa05332	1.97412638
15	Alzheimers disease_Homo sapiens_hsa05010	1.96451005
16	Huntingtons disease_Homo sapiens_hsa05016	1.94709383
17	Propanoate metabolism_Homo sapiens_hsa00640	1.87990756
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.87270353
19	Cardiac muscle contraction_Homo sapiens_hsa04260	1.86156698
20	RNA degradation_Homo sapiens_hsa03018	1.67089020
21	Phototransduction_Homo sapiens_hsa04744	1.66659076
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.63099342
23	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.59258966
24	Homologous recombination_Homo sapiens_hsa03440	1.52045000
25	Linoleic acid metabolism_Homo sapiens_hsa00591	1.46377332
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.40638765
27	Basal transcription factors_Homo sapiens_hsa03022	1.36275330
28	Mismatch repair_Homo sapiens_hsa03430	1.26882432
29	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.26165045
30	Nucleotide excision repair_Homo sapiens_hsa03420	1.24699746
31	Regulation of autophagy_Homo sapiens_hsa04140	1.20770083
32	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.19897179
33	Nicotine addiction_Homo sapiens_hsa05033	1.17045759
34	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.16375155
35	Rheumatoid arthritis_Homo sapiens_hsa05323	1.13166663
36	Fanconi anemia pathway_Homo sapiens_hsa03460	1.12403345
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.11501869
38	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.11002942
39	Peroxisome_Homo sapiens_hsa04146	1.05765263
40	One carbon pool by folate_Homo sapiens_hsa00670	1.05432159
41	Pyrimidine metabolism_Homo sapiens_hsa00240	1.05198587
42	Butanoate metabolism_Homo sapiens_hsa00650	0.97820702
43	Viral myocarditis_Homo sapiens_hsa05416	0.97117819
44	RNA transport_Homo sapiens_hsa03013	0.95414642
45	Purine metabolism_Homo sapiens_hsa00230	0.95273159
46	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.91449479
47	Caffeine metabolism_Homo sapiens_hsa00232	0.91250885
48	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.89050083
49	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.87937905
50	Spliceosome_Homo sapiens_hsa03040	0.87271265
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.85720920
52	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.78920141
53	Antigen processing and presentation_Homo sapiens_hsa04612	0.77671076
54	Fatty acid elongation_Homo sapiens_hsa00062	0.75541580
55	Base excision repair_Homo sapiens_hsa03410	0.74376417
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.72317871
57	Pyruvate metabolism_Homo sapiens_hsa00620	0.68946848
58	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.68531168
59	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.67376507
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.67335977
61	Retinol metabolism_Homo sapiens_hsa00830	0.65572369
62	Collecting duct acid secretion_Homo sapiens_hsa04966	0.64569780
63	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.64291301
64	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.63617168
65	Olfactory transduction_Homo sapiens_hsa04740	0.63412853
66	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.63079592
67	Non-homologous end-joining_Homo sapiens_hsa03450	0.62703073
68	Primary immunodeficiency_Homo sapiens_hsa05340	0.61815909
69	Nitrogen metabolism_Homo sapiens_hsa00910	0.61415134
70	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.61301473
71	Selenocompound metabolism_Homo sapiens_hsa00450	0.59201463
72	Metabolic pathways_Homo sapiens_hsa01100	0.58785343
73	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.56951007
74	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.54907611
75	Taste transduction_Homo sapiens_hsa04742	0.54227125
76	beta-Alanine metabolism_Homo sapiens_hsa00410	0.52820886
77	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.52087011
78	Ether lipid metabolism_Homo sapiens_hsa00565	0.51152914
79	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.50580573
80	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.49034348
81	Morphine addiction_Homo sapiens_hsa05032	0.46615194
82	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.45397812
83	Fat digestion and absorption_Homo sapiens_hsa04975	0.43987142
84	Serotonergic synapse_Homo sapiens_hsa04726	0.43113153
85	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.40322298
86	DNA replication_Homo sapiens_hsa03030	0.39683320
87	GABAergic synapse_Homo sapiens_hsa04727	0.38905379
88	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.38594833
89	Fatty acid degradation_Homo sapiens_hsa00071	0.37403459
90	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.35468745
91	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.34218685
92	Sulfur metabolism_Homo sapiens_hsa00920	0.34168988
93	Circadian entrainment_Homo sapiens_hsa04713	0.33382374
94	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.32634193
95	Glutamatergic synapse_Homo sapiens_hsa04724	0.31259835
96	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.30660985
97	Steroid biosynthesis_Homo sapiens_hsa00100	0.29377943
98	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.25925451
99	Glycerolipid metabolism_Homo sapiens_hsa00561	0.24512553
100	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.23766907

RPL5P18

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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