ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.21417012
2	behavioral response to nicotine (GO:0035095)	5.24694887
3	kynurenine metabolic process (GO:0070189)	4.78032975
4	water-soluble vitamin biosynthetic process (GO:0042364)	4.42679404
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.28467856
6	ATP synthesis coupled proton transport (GO:0015986)	4.28467856
7	ribosomal small subunit assembly (GO:0000028)	4.19156395
8	gonadal mesoderm development (GO:0007506)	4.17707834
9	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.14672448
10	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.14672448
11	tryptophan catabolic process (GO:0006569)	4.14097867
12	indole-containing compound catabolic process (GO:0042436)	4.14097867
13	indolalkylamine catabolic process (GO:0046218)	4.14097867
14	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.08392065
15	ribosomal large subunit biogenesis (GO:0042273)	3.90450629
16	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.78577544
17	cytidine metabolic process (GO:0046087)	3.69447613
18	cytidine catabolic process (GO:0006216)	3.69447613
19	cytidine deamination (GO:0009972)	3.69447613
20	protein neddylation (GO:0045116)	3.66137478
21	protein complex biogenesis (GO:0070271)	3.58457876
22	chaperone-mediated protein transport (GO:0072321)	3.54556650
23	viral transcription (GO:0019083)	3.39888455
24	tryptophan metabolic process (GO:0006568)	3.38788862
25	translational termination (GO:0006415)	3.38663141
26	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.36375061
27	regulation of regulatory T cell differentiation (GO:0045589)	3.35010330
28	amine catabolic process (GO:0009310)	3.34218658
29	cellular biogenic amine catabolic process (GO:0042402)	3.34218658
30	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.31510832
31	aldehyde catabolic process (GO:0046185)	3.28345755
32	preassembly of GPI anchor in ER membrane (GO:0016254)	3.25778970
33	positive regulation of interleukin-17 production (GO:0032740)	3.23043081
34	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.20169962
35	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.19109110
36	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.17602967
37	multicellular organism reproduction (GO:0032504)	3.13298442
38	mitochondrial respiratory chain complex assembly (GO:0033108)	3.12563264
39	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.10684555
40	response to pheromone (GO:0019236)	3.10621185
41	respiratory electron transport chain (GO:0022904)	3.07346134
42	electron transport chain (GO:0022900)	3.07126821
43	regulation of cilium movement (GO:0003352)	3.06845817
44	protein polyglutamylation (GO:0018095)	3.05120583
45	cellular response to exogenous dsRNA (GO:0071360)	3.01139808
46	cell wall macromolecule metabolic process (GO:0044036)	2.99068045
47	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.98805123
48	indolalkylamine metabolic process (GO:0006586)	2.95652695
49	ubiquinone metabolic process (GO:0006743)	2.94084878
50	maturation of SSU-rRNA (GO:0030490)	2.91748312
51	pseudouridine synthesis (GO:0001522)	2.91122475
52	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.90766647
53	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.90760168
54	NADH dehydrogenase complex assembly (GO:0010257)	2.90760168
55	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.90760168
56	cellular response to interferon-beta (GO:0035458)	2.87482128
57	protein targeting to ER (GO:0045047)	2.84830415
58	cotranslational protein targeting to membrane (GO:0006613)	2.84439503
59	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.82086699
60	piRNA metabolic process (GO:0034587)	2.81248037
61	axoneme assembly (GO:0035082)	2.79087707
62	translational elongation (GO:0006414)	2.78685878
63	protein localization to endoplasmic reticulum (GO:0070972)	2.76886802
64	behavioral response to ethanol (GO:0048149)	2.76087386
65	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.73528655
66	left/right axis specification (GO:0070986)	2.73161320
67	response to interferon-beta (GO:0035456)	2.71231821
68	L-methionine salvage (GO:0071267)	2.70684929
69	L-methionine biosynthetic process (GO:0071265)	2.70684929
70	amino acid salvage (GO:0043102)	2.70684929
71	peptidyl-histidine modification (GO:0018202)	2.70365600
72	DNA double-strand break processing (GO:0000729)	2.69208742
73	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.66619986
74	DNA methylation involved in gamete generation (GO:0043046)	2.66429069
75	cell wall macromolecule catabolic process (GO:0016998)	2.66250567
76	hydrogen ion transmembrane transport (GO:1902600)	2.65535274
77	cellular response to ATP (GO:0071318)	2.65026991
78	L-fucose catabolic process (GO:0042355)	2.64254623
79	fucose catabolic process (GO:0019317)	2.64254623
80	L-fucose metabolic process (GO:0042354)	2.64254623
81	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.63332342
82	estrogen biosynthetic process (GO:0006703)	2.62029423
83	benzene-containing compound metabolic process (GO:0042537)	2.61990978
84	protein-cofactor linkage (GO:0018065)	2.58437647
85	negative regulation of B cell apoptotic process (GO:0002903)	2.58383274
86	regulation of immunoglobulin secretion (GO:0051023)	2.57370419
87	GTP biosynthetic process (GO:0006183)	2.56340598
88	negative regulation of membrane potential (GO:0045837)	2.54261898
89	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.53991605
90	proton transport (GO:0015992)	2.53599919
91	cytochrome complex assembly (GO:0017004)	2.53585641
92	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.52141914
93	hydrogen transport (GO:0006818)	2.51720718
94	ATP biosynthetic process (GO:0006754)	2.50816014
95	rhodopsin mediated signaling pathway (GO:0016056)	2.50591854
96	aggressive behavior (GO:0002118)	2.50173995
97	mannosylation (GO:0097502)	2.50039721
98	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.49552634
99	positive regulation of defense response to virus by host (GO:0002230)	2.49112875
100	translation (GO:0006412)	2.47714590

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.57504864
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.36247633
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.18088240
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.80168848
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.77816856
6	VDR_22108803_ChIP-Seq_LS180_Human	2.62683314
7	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.40629190
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.37081828
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.35823485
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.26882735
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.26648261
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.22988831
13	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.12874397
14	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.98751303
15	TP53_22573176_ChIP-Seq_HFKS_Human	1.88021884
16	EZH2_22144423_ChIP-Seq_EOC_Human	1.87726776
17	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.87387830
18	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.84842133
19	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.79458996
20	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.75223485
21	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.71143621
22	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.70096003
23	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.69506683
24	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.65859818
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.65308780
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.64446701
27	VDR_23849224_ChIP-Seq_CD4+_Human	1.60674093
28	EWS_26573619_Chip-Seq_HEK293_Human	1.58721754
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.58401981
30	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.56989257
31	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.56830056
32	IGF1R_20145208_ChIP-Seq_DFB_Human	1.56701968
33	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.56036868
34	FUS_26573619_Chip-Seq_HEK293_Human	1.55665087
35	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.54766592
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.54766592
37	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.52286972
38	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.48271646
39	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.47729936
40	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.47729936
41	AR_20517297_ChIP-Seq_VCAP_Human	1.47032035
42	ELK1_19687146_ChIP-ChIP_HELA_Human	1.46930799
43	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.45094207
44	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.42049484
45	GBX2_23144817_ChIP-Seq_PC3_Human	1.38475058
46	SOX2_19829295_ChIP-Seq_ESCs_Human	1.38260457
47	NANOG_19829295_ChIP-Seq_ESCs_Human	1.38260457
48	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.38139175
49	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.38128252
50	IRF1_19129219_ChIP-ChIP_H3396_Human	1.37602037
51	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.36832773
52	FOXP3_21729870_ChIP-Seq_TREG_Human	1.35188522
53	BCAT_22108803_ChIP-Seq_LS180_Human	1.34646161
54	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.31027879
55	NCOR_22424771_ChIP-Seq_293T_Human	1.30004166
56	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.29810529
57	MYC_19829295_ChIP-Seq_ESCs_Human	1.29750806
58	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.26676379
59	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.26565038
60	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.25539881
61	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.25505958
62	P300_19829295_ChIP-Seq_ESCs_Human	1.25047780
63	GATA3_26560356_Chip-Seq_TH2_Human	1.24426799
64	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.24136126
65	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.23061025
66	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.22052785
67	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.21473168
68	HOXB7_26014856_ChIP-Seq_BT474_Human	1.19488558
69	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.17852416
70	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.16531815
71	NANOG_20526341_ChIP-Seq_ESCs_Human	1.16250136
72	CDX2_22108803_ChIP-Seq_LS180_Human	1.14515035
73	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.13579885
74	TAF2_19829295_ChIP-Seq_ESCs_Human	1.12238929
75	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.12053400
76	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.11320406
77	TCF4_22108803_ChIP-Seq_LS180_Human	1.11019084
78	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.09960616
79	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.09218622
80	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.07382552
81	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.07280777
82	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.05195706
83	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.04754329
84	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.04052856
85	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.02829857
86	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.01945537
87	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01887399
88	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.99381657
89	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.96712306
90	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.95352147
91	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.95113354
92	ERG_20517297_ChIP-Seq_VCAP_Human	0.93780321
93	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.93522416
94	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.91773285
95	REST_21632747_ChIP-Seq_MESCs_Mouse	0.91191383
96	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.91016930
97	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.90883907
98	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.90606786
99	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.90000066
100	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.88994331

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	3.71645893
2	MP0008877_abnormal_DNA_methylation	3.69516009
3	MP0002638_abnormal_pupillary_reflex	3.54572567
4	MP0006292_abnormal_olfactory_placode	3.21012866
5	MP0003787_abnormal_imprinting	3.13859372
6	MP0008875_abnormal_xenobiotic_pharmacok	2.84817847
7	MP0001835_abnormal_antigen_presentation	2.46545127
8	MP0003011_delayed_dark_adaptation	2.30019354
9	MP0003806_abnormal_nucleotide_metabolis	2.27772778
10	MP0001986_abnormal_taste_sensitivity	2.27246321
11	MP0002837_dystrophic_cardiac_calcinosis	2.23928105
12	MP0006072_abnormal_retinal_apoptosis	2.12686415
13	MP0002102_abnormal_ear_morphology	2.06487472
14	MP0005646_abnormal_pituitary_gland	1.99822745
15	MP0001968_abnormal_touch/_nociception	1.98296527
16	MP0003252_abnormal_bile_duct	1.95460079
17	MP0005423_abnormal_somatic_nervous	1.93833519
18	MP0004145_abnormal_muscle_electrophysio	1.93244795
19	MP0005671_abnormal_response_to	1.83860263
20	MP0003646_muscle_fatigue	1.80956135
21	MP0002139_abnormal_hepatobiliary_system	1.80021854
22	MP0008995_early_reproductive_senescence	1.78252497
23	MP0002138_abnormal_hepatobiliary_system	1.73859637
24	MP0004142_abnormal_muscle_tone	1.68835604
25	MP0000372_irregular_coat_pigmentation	1.67506635
26	MP0008775_abnormal_heart_ventricle	1.66895676
27	MP0001905_abnormal_dopamine_level	1.66617500
28	MP0008872_abnormal_physiological_respon	1.62837725
29	MP0005551_abnormal_eye_electrophysiolog	1.54411329
30	MP0004147_increased_porphyrin_level	1.45673541
31	MP0001529_abnormal_vocalization	1.45091158
32	MP0008789_abnormal_olfactory_epithelium	1.45037368
33	MP0003122_maternal_imprinting	1.44264689
34	MP0003195_calcinosis	1.43798247
35	MP0004885_abnormal_endolymph	1.43542014
36	MP0003121_genomic_imprinting	1.42591245
37	MP0005253_abnormal_eye_physiology	1.42272915
38	MP0002876_abnormal_thyroid_physiology	1.39650971
39	MP0002272_abnormal_nervous_system	1.37405854
40	MP0001440_abnormal_grooming_behavior	1.35283510
41	MP0009764_decreased_sensitivity_to	1.33617264
42	MP0000383_abnormal_hair_follicle	1.29933889
43	MP0009745_abnormal_behavioral_response	1.27396897
44	MP0002733_abnormal_thermal_nociception	1.27300488
45	MP0006276_abnormal_autonomic_nervous	1.25442372
46	MP0002736_abnormal_nociception_after	1.24402489
47	MP0003283_abnormal_digestive_organ	1.22149584
48	MP0001485_abnormal_pinna_reflex	1.19745853
49	MP0005389_reproductive_system_phenotype	1.10638087
50	MP0001970_abnormal_pain_threshold	1.09853948
51	MP0001984_abnormal_olfaction	1.08439313
52	MP0003186_abnormal_redox_activity	1.06213149
53	MP0005085_abnormal_gallbladder_physiolo	1.05509692
54	MP0001501_abnormal_sleep_pattern	1.04024333
55	MP0002148_abnormal_hypersensitivity_rea	1.00507477
56	MP0005379_endocrine/exocrine_gland_phen	1.00135603
57	MP0000427_abnormal_hair_cycle	0.99299823
58	MP0005645_abnormal_hypothalamus_physiol	0.98291343
59	MP0000647_abnormal_sebaceous_gland	0.98204901
60	MP0000230_abnormal_systemic_arterial	0.97407175
61	MP0002095_abnormal_skin_pigmentation	0.95783160
62	MP0001486_abnormal_startle_reflex	0.92535506
63	MP0001800_abnormal_humoral_immune	0.92456701
64	MP0005410_abnormal_fertilization	0.91486760
65	MP0002653_abnormal_ependyma_morphology	0.90810305
66	MP0004043_abnormal_pH_regulation	0.89772238
67	MP0010678_abnormal_skin_adnexa	0.89482710
68	MP0001919_abnormal_reproductive_system	0.85781360
69	MP0002163_abnormal_gland_morphology	0.84666552
70	MP0004019_abnormal_vitamin_homeostasis	0.84018298
71	MP0008058_abnormal_DNA_repair	0.83849314
72	MP0005000_abnormal_immune_tolerance	0.82686640
73	MP0008057_abnormal_DNA_replication	0.82397289
74	MP0002735_abnormal_chemical_nociception	0.82178955
75	MP0002693_abnormal_pancreas_physiology	0.82065618
76	MP0009046_muscle_twitch	0.81372940
77	MP0005084_abnormal_gallbladder_morpholo	0.81173642
78	MP0005365_abnormal_bile_salt	0.79639895
79	MP0001502_abnormal_circadian_rhythm	0.79454505
80	MP0001963_abnormal_hearing_physiology	0.79112656
81	MP0002160_abnormal_reproductive_system	0.79072607
82	MP0005394_taste/olfaction_phenotype	0.78580151
83	MP0005499_abnormal_olfactory_system	0.78580151
84	MP0003866_abnormal_defecation	0.78432539
85	MP0001764_abnormal_homeostasis	0.78390168
86	MP0004215_abnormal_myocardial_fiber	0.75437177
87	MP0004742_abnormal_vestibular_system	0.75139241
88	MP0003724_increased_susceptibility_to	0.74188282
89	MP0002751_abnormal_autonomic_nervous	0.72702200
90	MP0001293_anophthalmia	0.72390477
91	MP0003786_premature_aging	0.70681578
92	MP0009333_abnormal_splenocyte_physiolog	0.70673614
93	MP0006036_abnormal_mitochondrial_physio	0.70144812
94	MP0002572_abnormal_emotion/affect_behav	0.69278361
95	MP0005195_abnormal_posterior_eye	0.68844402
96	MP0001765_abnormal_ion_homeostasis	0.68211265
97	MP0002234_abnormal_pharynx_morphology	0.68058833
98	MP0002557_abnormal_social/conspecific_i	0.67841416
99	MP0002184_abnormal_innervation	0.67539934
100	MP0005075_abnormal_melanosome_morpholog	0.65973948

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of alanine metabolism (HP:0010916)	3.77371021
2	Hyperalaninemia (HP:0003348)	3.77371021
3	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.77371021
4	Mitochondrial inheritance (HP:0001427)	3.68274914
5	Abnormal rod and cone electroretinograms (HP:0008323)	3.67068521
6	Type 2 muscle fiber atrophy (HP:0003554)	3.60711375
7	Pancreatic fibrosis (HP:0100732)	3.59920528
8	3-Methylglutaconic aciduria (HP:0003535)	3.58325100
9	Pancreatic cysts (HP:0001737)	3.54570129
10	Increased hepatocellular lipid droplets (HP:0006565)	3.44766104
11	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.44311582
12	Elevated erythrocyte sedimentation rate (HP:0003565)	3.41309915
13	Acute necrotizing encephalopathy (HP:0006965)	3.37800559
14	Increased CSF lactate (HP:0002490)	3.32598779
15	Lipid accumulation in hepatocytes (HP:0006561)	3.27576721
16	Increased intramyocellular lipid droplets (HP:0012240)	3.26876044
17	Medial flaring of the eyebrow (HP:0010747)	3.20126752
18	Abnormal mitochondria in muscle tissue (HP:0008316)	3.16814684
19	Large for gestational age (HP:0001520)	3.13838985
20	Abnormality of midbrain morphology (HP:0002418)	3.11151506
21	Molar tooth sign on MRI (HP:0002419)	3.11151506
22	Attenuation of retinal blood vessels (HP:0007843)	3.00527503
23	True hermaphroditism (HP:0010459)	2.98593485
24	Muscle fiber atrophy (HP:0100295)	2.94533043
25	Progressive macrocephaly (HP:0004481)	2.90292725
26	Nephronophthisis (HP:0000090)	2.88912701
27	Renal Fanconi syndrome (HP:0001994)	2.86528132
28	Increased muscle lipid content (HP:0009058)	2.83701240
29	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.83431458
30	Hepatocellular necrosis (HP:0001404)	2.78589818
31	Stomatitis (HP:0010280)	2.75358262
32	Acute encephalopathy (HP:0006846)	2.72512735
33	IgG deficiency (HP:0004315)	2.68712931
34	Abolished electroretinogram (ERG) (HP:0000550)	2.67885327
35	Exertional dyspnea (HP:0002875)	2.55010665
36	Hepatic necrosis (HP:0002605)	2.49173537
37	Congenital stationary night blindness (HP:0007642)	2.46282578
38	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.42134248
39	Increased serum lactate (HP:0002151)	2.40692336
40	Polydipsia (HP:0001959)	2.35993869
41	Abnormal drinking behavior (HP:0030082)	2.35993869
42	Methylmalonic acidemia (HP:0002912)	2.35742376
43	Abnormality of cells of the erythroid lineage (HP:0012130)	2.35523865
44	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.31790452
45	Decreased circulating renin level (HP:0003351)	2.29959906
46	Congenital, generalized hypertrichosis (HP:0004540)	2.29930038
47	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.29046573
48	Abnormality of the renal medulla (HP:0100957)	2.27612684
49	Hypomagnesemia (HP:0002917)	2.26137419
50	Cerebral edema (HP:0002181)	2.25423454
51	Abnormality of B cell number (HP:0010975)	2.23688646
52	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.23630268
53	Sclerocornea (HP:0000647)	2.22449295
54	Optic disc pallor (HP:0000543)	2.21113012
55	Abnormal number of erythroid precursors (HP:0012131)	2.20795801
56	Lactic acidosis (HP:0003128)	2.20643358
57	Asplenia (HP:0001746)	2.17553171
58	Abnormality of renal resorption (HP:0011038)	2.16797996
59	Hypoproteinemia (HP:0003075)	2.16309543
60	Congenital hepatic fibrosis (HP:0002612)	2.14919927
61	Abnormality of magnesium homeostasis (HP:0004921)	2.13858998
62	Pendular nystagmus (HP:0012043)	2.11026710
63	Postaxial foot polydactyly (HP:0001830)	2.09540542
64	Polyuria (HP:0000103)	2.05849671
65	Abnormality of the renal cortex (HP:0011035)	2.05304536
66	Type II lissencephaly (HP:0007260)	2.04793363
67	Cystic liver disease (HP:0006706)	2.03852248
68	Decreased central vision (HP:0007663)	2.02728098
69	Glycosuria (HP:0003076)	1.95471826
70	Abnormality of urine glucose concentration (HP:0011016)	1.95471826
71	Fibular aplasia (HP:0002990)	1.94460528
72	Respiratory failure (HP:0002878)	1.93247301
73	Disproportionate short-trunk short stature (HP:0003521)	1.91613579
74	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.91502429
75	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.91502429
76	Macrocytic anemia (HP:0001972)	1.91271899
77	Thyroiditis (HP:0100646)	1.91139022
78	B lymphocytopenia (HP:0010976)	1.89629304
79	Broad alveolar ridges (HP:0000187)	1.89162176
80	Abnormality of T cell physiology (HP:0011840)	1.89144425
81	Stenosis of the external auditory canal (HP:0000402)	1.88192625
82	Abnormal urine output (HP:0012590)	1.87770718
83	Congenital primary aphakia (HP:0007707)	1.86623292
84	Stomach cancer (HP:0012126)	1.85740543
85	Abnormality of the middle phalanges of the toes (HP:0010183)	1.83504177
86	Gait imbalance (HP:0002141)	1.83472028
87	Porencephaly (HP:0002132)	1.82443342
88	Abnormality of renal excretion (HP:0011036)	1.80983646
89	Gaze-evoked nystagmus (HP:0000640)	1.79981819
90	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.79553915
91	Absent/shortened dynein arms (HP:0200106)	1.79104804
92	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.79104804
93	Aplasia/hypoplasia of the uterus (HP:0008684)	1.78322009
94	Male pseudohermaphroditism (HP:0000037)	1.76439893
95	Postaxial hand polydactyly (HP:0001162)	1.75564530
96	Intestinal atresia (HP:0011100)	1.75272800
97	Severe combined immunodeficiency (HP:0004430)	1.73575629
98	Hypoplasia of the uterus (HP:0000013)	1.73005681
99	Methylmalonic aciduria (HP:0012120)	1.71532537
100	Leukodystrophy (HP:0002415)	1.70434019

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.64797099
2	BCKDK	3.52888313
3	WNK4	3.40896078
4	ZAK	2.77523397
5	TAOK3	2.72232505
6	ADRBK2	2.50336422
7	PINK1	2.48280828
8	TAF1	2.46795495
9	TLK1	2.43938228
10	TXK	2.39892290
11	NUAK1	2.21610262
12	STK16	2.20405439
13	CDK19	2.19766533
14	STK39	2.19393070
15	TEC	2.03656489
16	GRK1	1.90193949
17	MAP4K2	1.77641778
18	OXSR1	1.76878374
19	PIK3CA	1.59113050
20	ITK	1.57471673
21	TIE1	1.56866254
22	GRK6	1.55643398
23	SIK2	1.51405316
24	BTK	1.46042139
25	PTK2B	1.34322502
26	CSNK1G3	1.22077927
27	NTRK3	1.20399267
28	ACVR1B	1.16356769
29	IKBKB	1.16105418
30	BMPR1B	1.15268603
31	WNK3	1.13465847
32	KIT	1.13336808
33	KDR	1.13320227
34	NEK1	1.12182778
35	ARAF	1.12098890
36	PASK	1.09245920
37	CSNK1G1	1.07408984
38	MAP3K9	1.04548159
39	SYK	1.01313513
40	CSNK1G2	1.00040600
41	EIF2AK3	0.99958187
42	CSNK1A1L	0.99861812
43	RPS6KA5	0.99489702
44	FES	0.96129269
45	PHKG1	0.90594990
46	PHKG2	0.90594990
47	IKBKE	0.89435843
48	MAP3K4	0.88718454
49	VRK2	0.87038830
50	INSRR	0.82559046
51	DAPK2	0.82481630
52	LYN	0.80512243
53	DYRK2	0.80374482
54	TNK2	0.80281928
55	ABL2	0.77921979
56	PRKCQ	0.77728066
57	MARK3	0.73051393
58	PIM2	0.69339340
59	MAPK13	0.66714967
60	BMPR2	0.66408499
61	RPS6KA6	0.63994845
62	LCK	0.63717916
63	ATR	0.62008245
64	ADRBK1	0.60719720
65	OBSCN	0.57460762
66	PRKCG	0.56993760
67	HIPK2	0.54917591
68	TRPM7	0.54218818
69	PRKCE	0.53135491
70	MAP2K2	0.51899325
71	PLK4	0.49870769
72	MKNK1	0.49841203
73	PRKACA	0.48912613
74	CSF1R	0.47112742
75	RPS6KC1	0.46058917
76	RPS6KL1	0.46058917
77	MAP3K12	0.45706227
78	PRKD3	0.45686481
79	MUSK	0.45683169
80	TESK2	0.45197295
81	PLK2	0.43631271
82	VRK1	0.43010698
83	PIM1	0.42962091
84	TRIM28	0.42052563
85	CHUK	0.41644297
86	CAMKK1	0.41177278
87	FGFR2	0.40796116
88	ABL1	0.40544404
89	MYLK	0.39826999
90	IGF1R	0.39396565
91	ERBB3	0.37194199
92	PRKCA	0.34543899
93	PRKCH	0.33558426
94	GRK7	0.32100109
95	RAF1	0.31127540
96	SCYL2	0.30873116
97	WNK1	0.30868286
98	RPS6KA1	0.29686597
99	CSNK2A1	0.29308680
100	EPHA4	0.28762055

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.75575242
2	Ribosome_Homo sapiens_hsa03010	3.36717139
3	Caffeine metabolism_Homo sapiens_hsa00232	3.23248800
4	Allograft rejection_Homo sapiens_hsa05330	3.13775992
5	Oxidative phosphorylation_Homo sapiens_hsa00190	3.09442084
6	Graft-versus-host disease_Homo sapiens_hsa05332	3.01268911
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.00050163
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.93837175
9	Type I diabetes mellitus_Homo sapiens_hsa04940	2.73019825
10	Parkinsons disease_Homo sapiens_hsa05012	2.52723107
11	Proteasome_Homo sapiens_hsa03050	2.37417743
12	Linoleic acid metabolism_Homo sapiens_hsa00591	1.96525747
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.90416622
14	Protein export_Homo sapiens_hsa03060	1.73205223
15	RNA polymerase_Homo sapiens_hsa03020	1.70589934
16	Primary immunodeficiency_Homo sapiens_hsa05340	1.67506724
17	Alzheimers disease_Homo sapiens_hsa05010	1.67072838
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.65245411
19	Phototransduction_Homo sapiens_hsa04744	1.60639269
20	Cardiac muscle contraction_Homo sapiens_hsa04260	1.58467567
21	Homologous recombination_Homo sapiens_hsa03440	1.56302559
22	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.51204370
23	Huntingtons disease_Homo sapiens_hsa05016	1.45591796
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.45350812
25	Rheumatoid arthritis_Homo sapiens_hsa05323	1.45272239
26	Ether lipid metabolism_Homo sapiens_hsa00565	1.39797321
27	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.38279771
28	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.36539242
29	Antigen processing and presentation_Homo sapiens_hsa04612	1.33062967
30	One carbon pool by folate_Homo sapiens_hsa00670	1.18740328
31	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.18687361
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.15223248
33	Propanoate metabolism_Homo sapiens_hsa00640	1.13631123
34	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.13067677
35	Fanconi anemia pathway_Homo sapiens_hsa03460	1.11707545
36	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.10581894
37	Nitrogen metabolism_Homo sapiens_hsa00910	1.08423514
38	Viral myocarditis_Homo sapiens_hsa05416	1.05945312
39	Fat digestion and absorption_Homo sapiens_hsa04975	1.05047624
40	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.02404665
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.02103511
42	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.00953098
43	Olfactory transduction_Homo sapiens_hsa04740	0.99723337
44	Chemical carcinogenesis_Homo sapiens_hsa05204	0.95934539
45	Peroxisome_Homo sapiens_hsa04146	0.94076116
46	Retinol metabolism_Homo sapiens_hsa00830	0.93496205
47	Collecting duct acid secretion_Homo sapiens_hsa04966	0.90953386
48	Taste transduction_Homo sapiens_hsa04742	0.90291864
49	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.90122580
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.88678756
51	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.88454225
52	RNA degradation_Homo sapiens_hsa03018	0.88269601
53	Pyrimidine metabolism_Homo sapiens_hsa00240	0.81208013
54	Butanoate metabolism_Homo sapiens_hsa00650	0.79826574
55	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.79691648
56	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.79204643
57	Basal transcription factors_Homo sapiens_hsa03022	0.78731677
58	Regulation of autophagy_Homo sapiens_hsa04140	0.77313933
59	Glycerolipid metabolism_Homo sapiens_hsa00561	0.75335321
60	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.72149815
61	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.71005417
62	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.70887508
63	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.69357771
64	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.68791390
65	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.67589718
66	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.65977564
67	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.65765089
68	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.64410505
69	Purine metabolism_Homo sapiens_hsa00230	0.58727685
70	Serotonergic synapse_Homo sapiens_hsa04726	0.55544896
71	Metabolic pathways_Homo sapiens_hsa01100	0.55483687
72	Nicotine addiction_Homo sapiens_hsa05033	0.55229290
73	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.53705464
74	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.50670429
75	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.49506986
76	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.49402300
77	Leishmaniasis_Homo sapiens_hsa05140	0.47582902
78	beta-Alanine metabolism_Homo sapiens_hsa00410	0.46115813
79	Morphine addiction_Homo sapiens_hsa05032	0.45809155
80	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.45122453
81	RNA transport_Homo sapiens_hsa03013	0.43323297
82	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.42726594
83	Circadian entrainment_Homo sapiens_hsa04713	0.42094799
84	Renin secretion_Homo sapiens_hsa04924	0.41486146
85	Salivary secretion_Homo sapiens_hsa04970	0.40984815
86	Base excision repair_Homo sapiens_hsa03410	0.40978264
87	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.37900134
88	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.35841090
89	Fatty acid elongation_Homo sapiens_hsa00062	0.34421338
90	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.32585128
91	Mismatch repair_Homo sapiens_hsa03430	0.31225114
92	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.29964848
93	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.29650545
94	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.29563319
95	Insulin secretion_Homo sapiens_hsa04911	0.26005417
96	GABAergic synapse_Homo sapiens_hsa04727	0.25684436
97	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.25199651
98	ABC transporters_Homo sapiens_hsa02010	0.24415047
99	Fatty acid degradation_Homo sapiens_hsa00071	0.21719428
100	Calcium signaling pathway_Homo sapiens_hsa04020	0.21231025

RPL5P20

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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