RPL5P22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.29523862
2ribosomal small subunit assembly (GO:0000028)6.24389930
3translational termination (GO:0006415)6.07121760
4ATP synthesis coupled proton transport (GO:0015986)5.27892416
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.27892416
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.21954099
7translational elongation (GO:0006414)5.21643931
8cotranslational protein targeting to membrane (GO:0006613)5.12045296
9protein targeting to ER (GO:0045047)5.11861733
10DNA deamination (GO:0045006)5.01207565
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.98844578
12ribosomal small subunit biogenesis (GO:0042274)4.91070562
13establishment of protein localization to endoplasmic reticulum (GO:0072599)4.87066116
14protein localization to endoplasmic reticulum (GO:0070972)4.83346333
15maturation of SSU-rRNA (GO:0030490)4.60420889
16viral life cycle (GO:0019058)4.54263184
17cellular protein complex disassembly (GO:0043624)4.50092170
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.34501545
19ribosomal large subunit biogenesis (GO:0042273)4.33525357
20regulation of isotype switching to IgG isotypes (GO:0048302)4.29250675
21cytidine deamination (GO:0009972)3.98944319
22cytidine metabolic process (GO:0046087)3.98944319
23cytidine catabolic process (GO:0006216)3.98944319
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.96830032
25protein neddylation (GO:0045116)3.95911532
26regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.91815519
27translational initiation (GO:0006413)3.85539283
28behavioral response to nicotine (GO:0035095)3.84224376
29base-excision repair, AP site formation (GO:0006285)3.69764185
30protein complex disassembly (GO:0043241)3.65009280
31electron transport chain (GO:0022900)3.53150510
32respiratory electron transport chain (GO:0022904)3.52858886
33protein complex biogenesis (GO:0070271)3.48405675
34macromolecular complex disassembly (GO:0032984)3.42555822
35positive regulation of prostaglandin secretion (GO:0032308)3.40824601
36pyrimidine ribonucleoside catabolic process (GO:0046133)3.36231600
37translation (GO:0006412)3.31945921
38protein targeting to membrane (GO:0006612)3.30202265
39nuclear-transcribed mRNA catabolic process (GO:0000956)3.25013744
40dopamine transport (GO:0015872)3.24561401
41nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.22241035
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.19002885
43mitochondrial respiratory chain complex I assembly (GO:0032981)3.19002885
44NADH dehydrogenase complex assembly (GO:0010257)3.19002885
45ATP biosynthetic process (GO:0006754)3.14680648
46exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.13844559
47mitochondrial respiratory chain complex assembly (GO:0033108)3.04138585
48mRNA catabolic process (GO:0006402)3.03928304
49positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.02927672
50establishment of protein localization to mitochondrial membrane (GO:0090151)2.98124112
51purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.95405113
52chaperone-mediated protein transport (GO:0072321)2.91637653
53positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.91579348
54positive regulation of defense response to virus by host (GO:0002230)2.91395064
55interferon-gamma production (GO:0032609)2.90958307
56purine nucleoside triphosphate biosynthetic process (GO:0009145)2.90146604
57pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.90094354
58mast cell activation (GO:0045576)2.87173832
59RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.82457781
60tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.82457781
61epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.81081257
62hydrogen ion transmembrane transport (GO:1902600)2.80783059
63regulation of appetite (GO:0032098)2.80264286
64cellular component biogenesis (GO:0044085)2.79690660
65regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.78543991
66mast cell activation involved in immune response (GO:0002279)2.77716946
67mast cell degranulation (GO:0043303)2.77716946
68kynurenine metabolic process (GO:0070189)2.77117805
69positive regulation of fatty acid transport (GO:2000193)2.76737769
70water-soluble vitamin biosynthetic process (GO:0042364)2.75286003
71RNA catabolic process (GO:0006401)2.74909945
72ubiquinone biosynthetic process (GO:0006744)2.74441970
73proton transport (GO:0015992)2.73408146
74detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.73142953
75ribonucleoprotein complex biogenesis (GO:0022613)2.71888886
76respiratory chain complex IV assembly (GO:0008535)2.71883315
77purine deoxyribonucleotide catabolic process (GO:0009155)2.70254550
78hydrogen transport (GO:0006818)2.70000912
79positive regulation of T cell mediated cytotoxicity (GO:0001916)2.68707345
80iron-sulfur cluster assembly (GO:0016226)2.67108104
81metallo-sulfur cluster assembly (GO:0031163)2.67108104
82regulation of regulatory T cell differentiation (GO:0045589)2.66042673
83positive regulation of icosanoid secretion (GO:0032305)2.65188642
84sequestering of actin monomers (GO:0042989)2.64687801
85lens fiber cell development (GO:0070307)2.63962122
86platelet dense granule organization (GO:0060155)2.63495078
87positive regulation of calcium-mediated signaling (GO:0050850)2.62375248
88regulation of hypersensitivity (GO:0002883)2.61542767
89cytochrome complex assembly (GO:0017004)2.59997553
90deoxyribonucleotide catabolic process (GO:0009264)2.59879555
91tryptophan catabolic process (GO:0006569)2.59663724
92indole-containing compound catabolic process (GO:0042436)2.59663724
93indolalkylamine catabolic process (GO:0046218)2.59663724
94ubiquinone metabolic process (GO:0006743)2.59142837
95RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.57203721
96response to interferon-beta (GO:0035456)2.56640362
97regulation of T cell mediated cytotoxicity (GO:0001914)2.55717565
98positive regulation of interleukin-17 production (GO:0032740)2.55228396
99deoxyribose phosphate catabolic process (GO:0046386)2.53793926
100regulation of prostaglandin secretion (GO:0032306)2.53250960

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.39670341
2EZH2_22144423_ChIP-Seq_EOC_Human3.76794575
3GABP_17652178_ChIP-ChIP_JURKAT_Human2.99800619
4BP1_19119308_ChIP-ChIP_Hs578T_Human2.70373083
5VDR_22108803_ChIP-Seq_LS180_Human2.62557963
6ZNF274_21170338_ChIP-Seq_K562_Hela2.58531750
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.52172204
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.33727363
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.21689143
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.19858528
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.12810913
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.94986367
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92488367
14FLI1_27457419_Chip-Seq_LIVER_Mouse1.87402676
15IRF8_22096565_ChIP-ChIP_GC-B_Human1.85013952
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76945502
17VDR_23849224_ChIP-Seq_CD4+_Human1.73974219
18BMI1_23680149_ChIP-Seq_NPCS_Mouse1.71283526
19ETS1_20019798_ChIP-Seq_JURKAT_Human1.71266795
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.67388003
21CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.61485390
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.61296210
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58220830
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57060840
25TP53_22573176_ChIP-Seq_HFKS_Human1.54477638
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48730009
27LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.47752757
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47133628
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.45453560
30MYC_18940864_ChIP-ChIP_HL60_Human1.40331297
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39276446
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.38545544
33NANOG_20526341_ChIP-Seq_ESCs_Human1.36467741
34EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.36391122
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.35970893
36TAF2_19829295_ChIP-Seq_ESCs_Human1.34342162
37GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33892869
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32288343
39FOXA1_25329375_ChIP-Seq_VCAP_Human1.32288343
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32082482
41IGF1R_20145208_ChIP-Seq_DFB_Human1.31354142
42GATA3_26560356_Chip-Seq_TH2_Human1.30986233
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30278011
44AR_20517297_ChIP-Seq_VCAP_Human1.27723206
45ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25728781
46AUTS2_25519132_ChIP-Seq_293T-REX_Human1.25362828
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25088096
48CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.24500749
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22953573
50NCOR_22424771_ChIP-Seq_293T_Human1.22439528
51GATA3_21878914_ChIP-Seq_MCF-7_Human1.21914208
52RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.21671728
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.20488054
54CREB1_15753290_ChIP-ChIP_HEK293T_Human1.20202735
55NANOG_19829295_ChIP-Seq_ESCs_Human1.19528520
56SOX2_19829295_ChIP-Seq_ESCs_Human1.19528520
57EWS_26573619_Chip-Seq_HEK293_Human1.19102548
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.17239082
59CBP_20019798_ChIP-Seq_JUKART_Human1.16770370
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16770370
61EZH2_27294783_Chip-Seq_ESCs_Mouse1.15416851
62EED_16625203_ChIP-ChIP_MESCs_Mouse1.15274810
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.14196444
64ELK1_19687146_ChIP-ChIP_HELA_Human1.14184102
65IRF8_21731497_ChIP-ChIP_J774_Mouse1.13140517
66PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11959606
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10089301
68FUS_26573619_Chip-Seq_HEK293_Human1.09443200
69P300_19829295_ChIP-Seq_ESCs_Human1.06854944
70FOXH1_21741376_ChIP-Seq_EPCs_Human1.06242175
71TDRD3_21172665_ChIP-Seq_MCF-7_Human1.05562582
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05260438
73GATA3_27048872_Chip-Seq_THYMUS_Human1.04534828
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04102803
75ER_23166858_ChIP-Seq_MCF-7_Human1.03847677
76SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03655595
77FOXP3_21729870_ChIP-Seq_TREG_Human1.03260379
78BCAT_22108803_ChIP-Seq_LS180_Human1.03005206
79CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02994860
80GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00907622
81BCL6_27268052_Chip-Seq_Bcells_Human1.00551501
82MYC_19829295_ChIP-Seq_ESCs_Human0.99374884
83TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98839536
84NFE2_27457419_Chip-Seq_LIVER_Mouse0.98112088
85IRF1_19129219_ChIP-ChIP_H3396_Human0.97578503
86EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97458347
87CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.97155177
88FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97113737
89STAT1_20625510_ChIP-Seq_HELA_Human0.96480295
90SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.96122908
91RUNX_20019798_ChIP-Seq_JUKART_Human0.95846300
92REST_21632747_ChIP-Seq_MESCs_Mouse0.95843138
93STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95436319
94ERA_21632823_ChIP-Seq_H3396_Human0.95079014
95SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94890687
96HTT_18923047_ChIP-ChIP_STHdh_Human0.93717030
97TAF15_26573619_Chip-Seq_HEK293_Human0.93654381
98KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93623647
99P53_21459846_ChIP-Seq_SAOS-2_Human0.92843186
100HOXB7_26014856_ChIP-Seq_BT474_Human0.92596839

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.24040596
2MP0005671_abnormal_response_to3.76570953
3MP0006292_abnormal_olfactory_placode2.73206483
4MP0002102_abnormal_ear_morphology2.69990197
5MP0002837_dystrophic_cardiac_calcinosis2.58859883
6MP0003646_muscle_fatigue2.33846748
7MP0001835_abnormal_antigen_presentation2.29098987
8MP0009785_altered_susceptibility_to2.11940521
9MP0002163_abnormal_gland_morphology2.04021216
10MP0006082_CNS_inflammation2.00739545
11MP0001968_abnormal_touch/_nociception1.92633814
12MP0006072_abnormal_retinal_apoptosis1.89952299
13MP0001800_abnormal_humoral_immune1.83860507
14MP0002653_abnormal_ependyma_morphology1.78387804
15MP0008872_abnormal_physiological_respon1.74161109
16MP0001905_abnormal_dopamine_level1.72019197
17MP0001986_abnormal_taste_sensitivity1.71347412
18MP0005645_abnormal_hypothalamus_physiol1.71058103
19MP0004145_abnormal_muscle_electrophysio1.69773848
20MP0005646_abnormal_pituitary_gland1.67761954
21MP0003011_delayed_dark_adaptation1.67312234
22MP0009333_abnormal_splenocyte_physiolog1.65145734
23MP0004885_abnormal_endolymph1.62738881
24MP0001873_stomach_inflammation1.61168087
25MP0003195_calcinosis1.61113772
26MP0003878_abnormal_ear_physiology1.60984085
27MP0005377_hearing/vestibular/ear_phenot1.60984085
28MP0005551_abnormal_eye_electrophysiolog1.55964200
29MP0003787_abnormal_imprinting1.51357602
30MP0004142_abnormal_muscle_tone1.51087924
31MP0002132_abnormal_respiratory_system1.49087724
32MP0005000_abnormal_immune_tolerance1.47022625
33MP0002723_abnormal_immune_serum1.41923085
34MP0008875_abnormal_xenobiotic_pharmacok1.39134468
35MP0002638_abnormal_pupillary_reflex1.38748785
36MP0008877_abnormal_DNA_methylation1.37266826
37MP0006276_abnormal_autonomic_nervous1.35654007
38MP0002148_abnormal_hypersensitivity_rea1.35319086
39MP0004147_increased_porphyrin_level1.34324097
40MP0002876_abnormal_thyroid_physiology1.29216569
41MP0005379_endocrine/exocrine_gland_phen1.28818078
42MP0003880_abnormal_central_pattern1.24780464
43MP0000372_irregular_coat_pigmentation1.23332223
44MP0003866_abnormal_defecation1.20084544
45MP0010155_abnormal_intestine_physiology1.19597305
46MP0009764_decreased_sensitivity_to1.18700065
47MP0005253_abnormal_eye_physiology1.18651392
48MP0005389_reproductive_system_phenotype1.17561491
49MP0005075_abnormal_melanosome_morpholog1.16960548
50MP0002736_abnormal_nociception_after1.16288026
51MP0002420_abnormal_adaptive_immunity1.15776971
52MP0001819_abnormal_immune_cell1.13603172
53MP0002272_abnormal_nervous_system1.12936841
54MP0001919_abnormal_reproductive_system1.12545240
55MP0008775_abnormal_heart_ventricle1.12493549
56MP0003252_abnormal_bile_duct1.12365750
57MP0003724_increased_susceptibility_to1.10555494
58MP0005025_abnormal_response_to1.09438629
59MP0002452_abnormal_antigen_presenting1.08852906
60MP0009745_abnormal_behavioral_response1.05941100
61MP0003186_abnormal_redox_activity1.05900666
62MP0005387_immune_system_phenotype1.05448832
63MP0001790_abnormal_immune_system1.05448832
64MP0003763_abnormal_thymus_physiology1.03395171
65MP0008995_early_reproductive_senescence1.01598190
66MP0002095_abnormal_skin_pigmentation1.01469472
67MP0005423_abnormal_somatic_nervous1.00110951
68MP0002405_respiratory_system_inflammati0.98223855
69MP0001501_abnormal_sleep_pattern0.97394584
70MP0001485_abnormal_pinna_reflex0.96715840
71MP0005084_abnormal_gallbladder_morpholo0.96148996
72MP0001845_abnormal_inflammatory_respons0.96118932
73MP0002160_abnormal_reproductive_system0.95174873
74MP0008789_abnormal_olfactory_epithelium0.94133955
75MP0000685_abnormal_immune_system0.89899702
76MP0001663_abnormal_digestive_system0.88701445
77MP0001765_abnormal_ion_homeostasis0.85084281
78MP0003638_abnormal_response/metabolism_0.84933436
79MP0010386_abnormal_urinary_bladder0.84868077
80MP0000230_abnormal_systemic_arterial0.84617648
81MP0001764_abnormal_homeostasis0.82641567
82MP0002277_abnormal_respiratory_mucosa0.82333281
83MP0000716_abnormal_immune_system0.82151986
84MP0005410_abnormal_fertilization0.82110754
85MP0008469_abnormal_protein_level0.81973534
86MP0005636_abnormal_mineral_homeostasis0.81050550
87MP0001440_abnormal_grooming_behavior0.78916275
88MP0004742_abnormal_vestibular_system0.77446836
89MP0002398_abnormal_bone_marrow0.76569588
90MP0003879_abnormal_hair_cell0.75476942
91MP0002234_abnormal_pharynx_morphology0.75075548
92MP0001970_abnormal_pain_threshold0.74389780
93MP0005085_abnormal_gallbladder_physiolo0.74068191
94MP0001963_abnormal_hearing_physiology0.72572746
95MP0002557_abnormal_social/conspecific_i0.71282530
96MP0006036_abnormal_mitochondrial_physio0.70743946
97MP0001188_hyperpigmentation0.70114464
98MP0000026_abnormal_inner_ear0.69223242
99MP0000049_abnormal_middle_ear0.69024372
100MP0002184_abnormal_innervation0.68550781

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.14245551
2Acute necrotizing encephalopathy (HP:0006965)4.13302165
3Mitochondrial inheritance (HP:0001427)3.84240356
4Absent rod-and cone-mediated responses on ERG (HP:0007688)3.73753095
5Abnormal mitochondria in muscle tissue (HP:0008316)3.72970746
6Macrocytic anemia (HP:0001972)3.55813717
7Abnormality of cells of the erythroid lineage (HP:0012130)3.48253395
8Acute encephalopathy (HP:0006846)3.42325619
9Increased CSF lactate (HP:0002490)3.40698071
10Progressive macrocephaly (HP:0004481)3.38104455
113-Methylglutaconic aciduria (HP:0003535)3.32006522
12Abnormal rod and cone electroretinograms (HP:0008323)3.29909106
13Hepatocellular necrosis (HP:0001404)3.29034830
14Congenital stationary night blindness (HP:0007642)3.27625186
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.13304345
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.13304345
17IgG deficiency (HP:0004315)3.11067124
18Increased hepatocellular lipid droplets (HP:0006565)3.10998243
19Reticulocytopenia (HP:0001896)3.10053733
20Pancreatic cysts (HP:0001737)3.09161291
21Abnormal number of erythroid precursors (HP:0012131)3.08585647
22Molar tooth sign on MRI (HP:0002419)2.96495336
23Abnormality of midbrain morphology (HP:0002418)2.96495336
24Pancreatic fibrosis (HP:0100732)2.91684052
25Lipid accumulation in hepatocytes (HP:0006561)2.87324842
26Hepatic necrosis (HP:0002605)2.83710656
27Renal Fanconi syndrome (HP:0001994)2.82537355
28Increased intramyocellular lipid droplets (HP:0012240)2.80644792
29Decreased central vision (HP:0007663)2.77238063
30Absent/shortened dynein arms (HP:0200106)2.71430935
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.71430935
32Severe combined immunodeficiency (HP:0004430)2.69544909
33True hermaphroditism (HP:0010459)2.69525027
34Attenuation of retinal blood vessels (HP:0007843)2.67153101
35Pendular nystagmus (HP:0012043)2.63457966
36Pallor (HP:0000980)2.62934587
37Optic disc pallor (HP:0000543)2.56545118
38Cerebral edema (HP:0002181)2.55647296
39Hypoproteinemia (HP:0003075)2.50116716
40Abolished electroretinogram (ERG) (HP:0000550)2.46487661
41Exertional dyspnea (HP:0002875)2.42931861
42Abnormal respiratory epithelium morphology (HP:0012253)2.36090849
43Abnormal respiratory motile cilium morphology (HP:0005938)2.36090849
44Increased muscle lipid content (HP:0009058)2.34626473
45Aplastic anemia (HP:0001915)2.32852522
46Abnormal hemoglobin (HP:0011902)2.31939006
47Medial flaring of the eyebrow (HP:0010747)2.25943568
48Thyroiditis (HP:0100646)2.25676269
49Nasal polyposis (HP:0100582)2.24353305
50Nephronophthisis (HP:0000090)2.24251305
51Myositis (HP:0100614)2.20019185
52Stomatitis (HP:0010280)2.19891796
53Increased serum lactate (HP:0002151)2.16497700
54Keratoconus (HP:0000563)2.16235202
55Increased corneal curvature (HP:0100692)2.16235202
56Asplenia (HP:0001746)2.13065883
57Type 2 muscle fiber atrophy (HP:0003554)2.10965203
58Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.08310531
59Lactic acidosis (HP:0003128)2.08221979
60Aplasia/Hypoplasia of the spleen (HP:0010451)2.07218253
61Stenosis of the external auditory canal (HP:0000402)2.05694712
62Colon cancer (HP:0003003)2.04423669
63Renal cortical cysts (HP:0000803)2.04337874
64Polydipsia (HP:0001959)2.04120464
65Abnormal drinking behavior (HP:0030082)2.04120464
66Abnormality of B cell number (HP:0010975)2.01369816
67Abnormality of the renal cortex (HP:0011035)2.01246756
68Abnormality of T cells (HP:0002843)2.00421221
69Abnormality of T cell number (HP:0011839)1.99876697
70Abnormality of renal resorption (HP:0011038)1.99492337
71Respiratory failure (HP:0002878)1.97852642
72Abnormal ciliary motility (HP:0012262)1.97495469
73Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.96862370
74T lymphocytopenia (HP:0005403)1.96674734
75Sclerocornea (HP:0000647)1.95534843
76Abnormal respiratory motile cilium physiology (HP:0012261)1.95299270
77Abnormality of the prostate (HP:0008775)1.92121262
78Stomach cancer (HP:0012126)1.91807281
79Decreased electroretinogram (ERG) amplitude (HP:0000654)1.91348316
80Absent thumb (HP:0009777)1.90046783
81Combined immunodeficiency (HP:0005387)1.89395792
82Cystic liver disease (HP:0006706)1.87850256
83Congenital, generalized hypertrichosis (HP:0004540)1.87363113
84Constricted visual fields (HP:0001133)1.85588646
85Abnormality of the renal medulla (HP:0100957)1.85486855
86Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.84801594
87Chronic hepatic failure (HP:0100626)1.83578250
88Thrombocytosis (HP:0001894)1.82235824
89Abnormality of the phalanges of the 2nd finger (HP:0009541)1.80629077
90Increased IgM level (HP:0003496)1.79487729
91Leukodystrophy (HP:0002415)1.78894346
92Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77511319
93Abnormality of alanine metabolism (HP:0010916)1.77511319
94Hyperalaninemia (HP:0003348)1.77511319
95Hypoplasia of the ulna (HP:0003022)1.77419605
96Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.77242405
97Symphalangism affecting the phalanges of the hand (HP:0009773)1.77099368
98Lethargy (HP:0001254)1.76447401
99Type II lissencephaly (HP:0007260)1.76223340
100Hypoglycemic seizures (HP:0002173)1.75668780

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.24723180
2TLK13.37606325
3ADRBK23.08538789
4PASK3.00409898
5WNK42.73085992
6ITK2.58538410
7KDR2.49959169
8GRK12.39061837
9TESK22.15520706
10STK162.14419385
11MAP4K22.05619500
12TAOK32.03976505
13ZAK2.01787753
14BCKDK2.00925928
15MAP3K121.98815057
16MAP4K11.91170257
17FRK1.80745161
18STK391.76236769
19TEC1.60319517
20PINK11.55977374
21SYK1.35505977
22CDK191.34179051
23WNK31.33370861
24NEK11.32597240
25CAMKK11.31196501
26MUSK1.25277992
27BTK1.24129096
28INSRR1.20340875
29GRK61.16821189
30CAMKK21.11983067
31BMPR21.10646356
32BMPR1B1.06517457
33TIE11.06404755
34RIPK41.06078116
35OXSR11.05870513
36FES1.04973698
37ZAP701.03811787
38LCK1.03165966
39IKBKB1.02828636
40NUAK11.00630268
41KIT0.98867235
42PRKCQ0.98207160
43MYLK0.95324272
44PIK3CA0.92370457
45MAPK130.91989045
46RPS6KA50.91348131
47DYRK20.88530017
48LYN0.86075175
49VRK20.83412941
50VRK10.81530441
51ADRBK10.81508455
52NME20.80083492
53OBSCN0.78974478
54PIM20.77229174
55PIM10.76942971
56PTK2B0.72335141
57DAPK30.71099313
58ABL20.70464918
59MAP3K110.69903054
60IKBKE0.69791547
61LRRK20.69617303
62PHKG10.68861747
63PHKG20.68861747
64TBK10.68346523
65GRK70.66817162
66PIK3CG0.64885332
67CSF1R0.61290120
68LIMK10.60172492
69DAPK10.58653762
70PRKACA0.57851643
71PLK40.57572689
72JAK30.55474362
73SCYL20.54824300
74IGF1R0.54822782
75MATK0.54184541
76NTRK30.53577098
77PRKCA0.50917400
78NEK20.48674324
79PRKCG0.47615374
80CSK0.43193230
81ERBB20.43058974
82MAP2K60.42913414
83SIK20.42865252
84CSNK1A10.42081900
85TNK20.41070856
86CSNK1G20.40582526
87DAPK20.40352846
88HCK0.40264253
89CAMK10.40255422
90CDC70.40197204
91CSNK2A20.39052956
92CAMK2A0.38624614
93PKN10.38191578
94MAP3K40.37602627
95CSNK2A10.37350723
96PRKCD0.36821510
97FYN0.36259118
98PAK30.35174254
99CSNK1G30.33083460
100NME10.32796626

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.06514106
2Oxidative phosphorylation_Homo sapiens_hsa001903.69410196
3Graft-versus-host disease_Homo sapiens_hsa053323.18417630
4Parkinsons disease_Homo sapiens_hsa050122.86527793
5Primary immunodeficiency_Homo sapiens_hsa053402.82525165
6Asthma_Homo sapiens_hsa053102.81935263
7Allograft rejection_Homo sapiens_hsa053302.71099368
8Proteasome_Homo sapiens_hsa030502.67824838
9Autoimmune thyroid disease_Homo sapiens_hsa053202.60794214
10Type I diabetes mellitus_Homo sapiens_hsa049402.23494456
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.20061299
12Linoleic acid metabolism_Homo sapiens_hsa005912.01785175
13Alzheimers disease_Homo sapiens_hsa050101.95528795
14Antigen processing and presentation_Homo sapiens_hsa046121.87632719
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.86873767
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.85733570
17Huntingtons disease_Homo sapiens_hsa050161.85218867
18Cardiac muscle contraction_Homo sapiens_hsa042601.77366294
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.72516697
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68969870
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67629524
22RNA polymerase_Homo sapiens_hsa030201.62626306
23Phototransduction_Homo sapiens_hsa047441.55706196
24Protein export_Homo sapiens_hsa030601.53568380
25Caffeine metabolism_Homo sapiens_hsa002321.45847827
26Rheumatoid arthritis_Homo sapiens_hsa053231.45496997
27RNA degradation_Homo sapiens_hsa030181.44553442
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40820024
29Nitrogen metabolism_Homo sapiens_hsa009101.34376611
30Hematopoietic cell lineage_Homo sapiens_hsa046401.28158562
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.25620548
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14183866
33Homologous recombination_Homo sapiens_hsa034401.13530524
34Olfactory transduction_Homo sapiens_hsa047400.97652128
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96401200
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94923077
37Arachidonic acid metabolism_Homo sapiens_hsa005900.94021913
38One carbon pool by folate_Homo sapiens_hsa006700.92896332
39Staphylococcus aureus infection_Homo sapiens_hsa051500.91807761
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90862856
41Drug metabolism - other enzymes_Homo sapiens_hsa009830.90454143
42Steroid hormone biosynthesis_Homo sapiens_hsa001400.88994819
43Nicotine addiction_Homo sapiens_hsa050330.88407346
44Pyrimidine metabolism_Homo sapiens_hsa002400.87914380
45T cell receptor signaling pathway_Homo sapiens_hsa046600.86042974
46Retinol metabolism_Homo sapiens_hsa008300.84785566
47Fat digestion and absorption_Homo sapiens_hsa049750.84766771
48Ether lipid metabolism_Homo sapiens_hsa005650.84726858
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84664110
50Viral myocarditis_Homo sapiens_hsa054160.83823200
51Chemical carcinogenesis_Homo sapiens_hsa052040.82447960
52Sulfur relay system_Homo sapiens_hsa041220.80975910
53Butanoate metabolism_Homo sapiens_hsa006500.80112275
54Basal transcription factors_Homo sapiens_hsa030220.77835430
55Tryptophan metabolism_Homo sapiens_hsa003800.76658803
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75951063
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.73926059
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71534699
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70412652
60Collecting duct acid secretion_Homo sapiens_hsa049660.69319299
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.68705240
62Systemic lupus erythematosus_Homo sapiens_hsa053220.67908151
63Peroxisome_Homo sapiens_hsa041460.65772577
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.65164915
65Purine metabolism_Homo sapiens_hsa002300.65083405
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64059275
67Taste transduction_Homo sapiens_hsa047420.59897583
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58628743
69Fanconi anemia pathway_Homo sapiens_hsa034600.55759225
70Malaria_Homo sapiens_hsa051440.54107422
71Morphine addiction_Homo sapiens_hsa050320.53828415
72Base excision repair_Homo sapiens_hsa034100.52138040
73Nucleotide excision repair_Homo sapiens_hsa034200.51767735
74Metabolic pathways_Homo sapiens_hsa011000.49706969
75Regulation of autophagy_Homo sapiens_hsa041400.49442692
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49369572
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42579205
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39685264
79Leishmaniasis_Homo sapiens_hsa051400.38046597
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37525954
81Mismatch repair_Homo sapiens_hsa034300.36420761
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36111782
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35358332
84Salivary secretion_Homo sapiens_hsa049700.35169907
85Sulfur metabolism_Homo sapiens_hsa009200.33907791
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33704851
87DNA replication_Homo sapiens_hsa030300.32697598
88Spliceosome_Homo sapiens_hsa030400.32119089
89African trypanosomiasis_Homo sapiens_hsa051430.31201369
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27020555
91Tyrosine metabolism_Homo sapiens_hsa003500.26387762
92Selenocompound metabolism_Homo sapiens_hsa004500.25553707
93Serotonergic synapse_Homo sapiens_hsa047260.23636905
94Ovarian steroidogenesis_Homo sapiens_hsa049130.22703182
95Propanoate metabolism_Homo sapiens_hsa006400.22685605
96RNA transport_Homo sapiens_hsa030130.21728815
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.21525294
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20819762
99Measles_Homo sapiens_hsa051620.20414288
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.19787016

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