ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	4.81733752
2	water-soluble vitamin biosynthetic process (GO:0042364)	4.32707000
3	ATP synthesis coupled proton transport (GO:0015986)	4.29635979
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.29635979
5	interferon-gamma production (GO:0032609)	3.97652602
6	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.94041716
7	protein complex biogenesis (GO:0070271)	3.90855889
8	protein neddylation (GO:0045116)	3.88594806
9	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.68669651
10	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.63720486
11	mitochondrial respiratory chain complex assembly (GO:0033108)	3.62611199
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.60247267
13	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.57814994
14	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.55468754
15	NADH dehydrogenase complex assembly (GO:0010257)	3.55468754
16	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.55468754
17	response to pheromone (GO:0019236)	3.52318101
18	respiratory chain complex IV assembly (GO:0008535)	3.46807350
19	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.42802674
20	preassembly of GPI anchor in ER membrane (GO:0016254)	3.39745395
21	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.38958734
22	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.38958734
23	kynurenine metabolic process (GO:0070189)	3.28124187
24	regulation of cellular amino acid metabolic process (GO:0006521)	3.25035258
25	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.22768436
26	pseudouridine synthesis (GO:0001522)	3.21467340
27	regulation of cilium movement (GO:0003352)	3.19047057
28	proteasome assembly (GO:0043248)	3.17771665
29	indolalkylamine metabolic process (GO:0006586)	3.15458620
30	mannosylation (GO:0097502)	3.14053056
31	rRNA modification (GO:0000154)	3.13802788
32	cytochrome complex assembly (GO:0017004)	3.12909789
33	tryptophan metabolic process (GO:0006568)	3.12092027
34	protein deneddylation (GO:0000338)	3.12052159
35	piRNA metabolic process (GO:0034587)	3.10946945
36	cullin deneddylation (GO:0010388)	3.09705085
37	aldehyde catabolic process (GO:0046185)	3.08052742
38	electron transport chain (GO:0022900)	3.03458136
39	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.01734865
40	tryptophan catabolic process (GO:0006569)	3.01380773
41	indole-containing compound catabolic process (GO:0042436)	3.01380773
42	indolalkylamine catabolic process (GO:0046218)	3.01380773
43	respiratory electron transport chain (GO:0022904)	3.01290647
44	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.98678971
45	rRNA catabolic process (GO:0016075)	2.96575106
46	behavioral response to nicotine (GO:0035095)	2.96563301
47	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.95858102
48	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.95858102
49	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.95858102
50	ubiquinone biosynthetic process (GO:0006744)	2.93190593
51	protein polyglutamylation (GO:0018095)	2.91787079
52	GPI anchor metabolic process (GO:0006505)	2.90528247
53	maturation of 5.8S rRNA (GO:0000460)	2.89244533
54	tRNA processing (GO:0008033)	2.89235541
55	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.87634317
56	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.87634317
57	adenosine metabolic process (GO:0046085)	2.87385777
58	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.81136533
59	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.81136533
60	L-fucose metabolic process (GO:0042354)	2.79164191
61	L-fucose catabolic process (GO:0042355)	2.79164191
62	fucose catabolic process (GO:0019317)	2.79164191
63	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.79137529
64	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.77416037
65	lactate metabolic process (GO:0006089)	2.76979057
66	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.75260137
67	GPI anchor biosynthetic process (GO:0006506)	2.75241905
68	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.71907258
69	branched-chain amino acid catabolic process (GO:0009083)	2.71020923
70	positive regulation of protein homodimerization activity (GO:0090073)	2.70987402
71	DNA double-strand break processing (GO:0000729)	2.70060849
72	platelet dense granule organization (GO:0060155)	2.67488101
73	negative regulation of ligase activity (GO:0051352)	2.66286298
74	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.66286298
75	ubiquinone metabolic process (GO:0006743)	2.63755627
76	protein-cofactor linkage (GO:0018065)	2.63103014
77	cytidine deamination (GO:0009972)	2.60509633
78	cytidine metabolic process (GO:0046087)	2.60509633
79	cytidine catabolic process (GO:0006216)	2.60509633
80	GMP metabolic process (GO:0046037)	2.59464066
81	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.58456951
82	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.58108723
83	iron-sulfur cluster assembly (GO:0016226)	2.55594654
84	metallo-sulfur cluster assembly (GO:0031163)	2.55594654
85	inositol phosphate catabolic process (GO:0071545)	2.54961687
86	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.54920375
87	proton transport (GO:0015992)	2.54781114
88	hydrogen ion transmembrane transport (GO:1902600)	2.54273869
89	chaperone-mediated protein transport (GO:0072321)	2.54069697
90	ATP biosynthetic process (GO:0006754)	2.54001779
91	cellular ketone body metabolic process (GO:0046950)	2.53919522
92	replication fork processing (GO:0031297)	2.53497181
93	hydrogen transport (GO:0006818)	2.51087213
94	rRNA methylation (GO:0031167)	2.50635854
95	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.50426681
96	base-excision repair, AP site formation (GO:0006285)	2.50414214
97	tRNA metabolic process (GO:0006399)	2.47012105
98	DNA demethylation (GO:0080111)	2.46129218
99	positive regulation of defense response to virus by host (GO:0002230)	2.45749549
100	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.41559117

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.26203981
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.98393259
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.19803586
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.11038287
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.08378885
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.03624165
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.86671421
8	VDR_22108803_ChIP-Seq_LS180_Human	2.82160842
9	VDR_23849224_ChIP-Seq_CD4+_Human	2.47541354
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.45328972
11	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.42890455
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.41668551
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.37982018
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.35250010
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.27066972
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.24351513
17	FOXP3_21729870_ChIP-Seq_TREG_Human	2.03954665
18	EWS_26573619_Chip-Seq_HEK293_Human	1.98614038
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.93562552
20	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.93369896
21	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.85816126
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.84050730
23	FUS_26573619_Chip-Seq_HEK293_Human	1.82314637
24	TAF15_26573619_Chip-Seq_HEK293_Human	1.81087138
25	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.78678300
26	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.78145921
27	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.76802984
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.73025920
29	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.72181283
30	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.71079270
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.70971201
32	GBX2_23144817_ChIP-Seq_PC3_Human	1.68522081
33	IRF1_19129219_ChIP-ChIP_H3396_Human	1.66161338
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.61175695
35	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.55917632
36	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.54971436
37	P300_19829295_ChIP-Seq_ESCs_Human	1.51619927
38	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.50312100
39	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.40323538
40	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.39818628
41	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.37635115
42	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.32684942
43	CBP_20019798_ChIP-Seq_JUKART_Human	1.32684942
44	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.32548477
45	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.32548477
46	AR_20517297_ChIP-Seq_VCAP_Human	1.30567735
47	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.29593868
48	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.28801943
49	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.28610588
50	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.28485203
51	SOX2_19829295_ChIP-Seq_ESCs_Human	1.28320481
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.28320481
53	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.28228721
54	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.27681158
55	ER_23166858_ChIP-Seq_MCF-7_Human	1.27519576
56	GATA3_26560356_Chip-Seq_TH2_Human	1.27343682
57	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.27295207
58	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.23641067
59	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.22011377
60	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.21951319
61	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.21301860
62	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.16237902
63	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.15622562
64	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.15206983
65	NCOR_22424771_ChIP-Seq_293T_Human	1.14145707
66	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.14007507
67	GABP_19822575_ChIP-Seq_HepG2_Human	1.13351067
68	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12683623
69	HOXB7_26014856_ChIP-Seq_BT474_Human	1.12364223
70	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12148746
71	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.09622884
72	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.08268112
73	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.08207342
74	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.08019065
75	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.07399771
76	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.06936914
77	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.06471262
78	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.06227082
79	BCAT_22108803_ChIP-Seq_LS180_Human	1.02915716
80	TCF4_22108803_ChIP-Seq_LS180_Human	1.02207046
81	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.02008673
82	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.00767272
83	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.98370882
84	NANOG_20526341_ChIP-Seq_ESCs_Human	0.97597600
85	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.96284427
86	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.96149842
87	TTF2_22483619_ChIP-Seq_HELA_Human	0.95962536
88	CDX2_22108803_ChIP-Seq_LS180_Human	0.95545650
89	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.94205399
90	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.91629420
91	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90384065
92	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.90352094
93	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.90051951
94	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.89369083
95	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.88188593
96	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.87334924
97	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.85988942
98	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.85890955
99	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.85588722
100	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.85235761

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	2.92431371
2	MP0008877_abnormal_DNA_methylation	2.84402728
3	MP0002102_abnormal_ear_morphology	2.78403998
4	MP0000372_irregular_coat_pigmentation	2.60306293
5	MP0008875_abnormal_xenobiotic_pharmacok	2.59676350
6	MP0006072_abnormal_retinal_apoptosis	2.55950364
7	MP0003646_muscle_fatigue	2.30078486
8	MP0005671_abnormal_response_to	2.29415937
9	MP0001835_abnormal_antigen_presentation	2.10931626
10	MP0005646_abnormal_pituitary_gland	2.10140976
11	MP0008872_abnormal_physiological_respon	2.07372365
12	MP0006292_abnormal_olfactory_placode	1.97119830
13	MP0003011_delayed_dark_adaptation	1.96040443
14	MP0005084_abnormal_gallbladder_morpholo	1.93944148
15	MP0008058_abnormal_DNA_repair	1.92059980
16	MP0005551_abnormal_eye_electrophysiolog	1.91097678
17	MP0005253_abnormal_eye_physiology	1.82726752
18	MP0005645_abnormal_hypothalamus_physiol	1.82064706
19	MP0002837_dystrophic_cardiac_calcinosis	1.76213349
20	MP0001986_abnormal_taste_sensitivity	1.75756467
21	MP0003195_calcinosis	1.73886242
22	MP0002736_abnormal_nociception_after	1.66846517
23	MP0001968_abnormal_touch/_nociception	1.61042855
24	MP0006276_abnormal_autonomic_nervous	1.60971444
25	MP0002638_abnormal_pupillary_reflex	1.58641883
26	MP0006036_abnormal_mitochondrial_physio	1.55262061
27	MP0003693_abnormal_embryo_hatching	1.51079405
28	MP0004043_abnormal_pH_regulation	1.47598081
29	MP0002876_abnormal_thyroid_physiology	1.46801112
30	MP0004142_abnormal_muscle_tone	1.45060695
31	MP0002138_abnormal_hepatobiliary_system	1.42527027
32	MP0005389_reproductive_system_phenotype	1.42490160
33	MP0009785_altered_susceptibility_to	1.41410789
34	MP0005075_abnormal_melanosome_morpholog	1.39483238
35	MP0008775_abnormal_heart_ventricle	1.38755483
36	MP0003786_premature_aging	1.36658653
37	MP0004885_abnormal_endolymph	1.35295139
38	MP0003806_abnormal_nucleotide_metabolis	1.34253789
39	MP0001873_stomach_inflammation	1.32395555
40	MP0002148_abnormal_hypersensitivity_rea	1.30357877
41	MP0002160_abnormal_reproductive_system	1.27623044
42	MP0003718_maternal_effect	1.26858956
43	MP0001919_abnormal_reproductive_system	1.25400546
44	MP0009764_decreased_sensitivity_to	1.25017927
45	MP0004145_abnormal_muscle_electrophysio	1.23751634
46	MP0006035_abnormal_mitochondrial_morpho	1.22706262
47	MP0006054_spinal_hemorrhage	1.20265034
48	MP0001984_abnormal_olfaction	1.16402284
49	MP0005636_abnormal_mineral_homeostasis	1.16394799
50	MP0002166_altered_tumor_susceptibility	1.16101924
51	MP0009697_abnormal_copulation	1.11874804
52	MP0003186_abnormal_redox_activity	1.10615044
53	MP0002006_tumorigenesis	1.09936479
54	MP0001800_abnormal_humoral_immune	1.08990008
55	MP0008789_abnormal_olfactory_epithelium	1.08248660
56	MP0002272_abnormal_nervous_system	1.07299268
57	MP0001485_abnormal_pinna_reflex	1.07246803
58	MP0005332_abnormal_amino_acid	1.05745893
59	MP0003567_abnormal_fetal_cardiomyocyte	1.05634398
60	MP0001764_abnormal_homeostasis	1.04129852
61	MP0004215_abnormal_myocardial_fiber	1.02347555
62	MP0001905_abnormal_dopamine_level	1.01234069
63	MP0004782_abnormal_surfactant_physiolog	0.99344949
64	MP0000427_abnormal_hair_cycle	0.99235187
65	MP0001529_abnormal_vocalization	0.97373276
66	MP0001765_abnormal_ion_homeostasis	0.96170485
67	MP0003136_yellow_coat_color	0.96000145
68	MP0005410_abnormal_fertilization	0.93371872
69	MP0001501_abnormal_sleep_pattern	0.92516404
70	MP0005377_hearing/vestibular/ear_phenot	0.92320321
71	MP0003878_abnormal_ear_physiology	0.92320321
72	MP0010094_abnormal_chromosome_stability	0.90051305
73	MP0002938_white_spotting	0.89691501
74	MP0003763_abnormal_thymus_physiology	0.89393948
75	MP0009745_abnormal_behavioral_response	0.89231666
76	MP0003724_increased_susceptibility_to	0.88263389
77	MP0008057_abnormal_DNA_replication	0.87144198
78	MP0003252_abnormal_bile_duct	0.86719974
79	MP0002723_abnormal_immune_serum	0.85843181
80	MP0005000_abnormal_immune_tolerance	0.84407540
81	MP0003787_abnormal_imprinting	0.83934746
82	MP0002693_abnormal_pancreas_physiology	0.83361908
83	MP0000230_abnormal_systemic_arterial	0.80530456
84	MP0001486_abnormal_startle_reflex	0.79518520
85	MP0001929_abnormal_gametogenesis	0.79122953
86	MP0001293_anophthalmia	0.78885656
87	MP0002163_abnormal_gland_morphology	0.77711434
88	MP0001756_abnormal_urination	0.77632884
89	MP0002751_abnormal_autonomic_nervous	0.76227769
90	MP0002277_abnormal_respiratory_mucosa	0.75146550
91	MP0009046_muscle_twitch	0.75134152
92	MP0001790_abnormal_immune_system	0.74792127
93	MP0005387_immune_system_phenotype	0.74792127
94	MP0003880_abnormal_central_pattern	0.74251939
95	MP0008995_early_reproductive_senescence	0.73858667
96	MP0001661_extended_life_span	0.71881068
97	MP0002234_abnormal_pharynx_morphology	0.70483039
98	MP0010386_abnormal_urinary_bladder	0.68861421
99	MP0000689_abnormal_spleen_morphology	0.68707014
100	MP0002452_abnormal_antigen_presenting	0.68652352

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	4.35078154
2	Acute necrotizing encephalopathy (HP:0006965)	3.73832627
3	Mitochondrial inheritance (HP:0001427)	3.59686837
4	Increased CSF lactate (HP:0002490)	3.54899219
5	Methylmalonic acidemia (HP:0002912)	3.47947702
6	Acute encephalopathy (HP:0006846)	3.36115456
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.33513429
8	Lipid accumulation in hepatocytes (HP:0006561)	3.33448215
9	Increased hepatocellular lipid droplets (HP:0006565)	3.28264510
10	Polydipsia (HP:0001959)	3.25132703
11	Abnormal drinking behavior (HP:0030082)	3.25132703
12	Pancreatic cysts (HP:0001737)	3.20113826
13	Progressive macrocephaly (HP:0004481)	3.16692065
14	Abnormality of midbrain morphology (HP:0002418)	3.10248382
15	Molar tooth sign on MRI (HP:0002419)	3.10248382
16	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.05600819
17	Abolished electroretinogram (ERG) (HP:0000550)	3.04568374
18	Hepatocellular necrosis (HP:0001404)	3.01150648
19	Nephronophthisis (HP:0000090)	2.96243203
20	Pancreatic fibrosis (HP:0100732)	2.95604992
21	Stomatitis (HP:0010280)	2.89949685
22	Hepatic necrosis (HP:0002605)	2.88778554
23	Decreased circulating renin level (HP:0003351)	2.86194699
24	IgG deficiency (HP:0004315)	2.80495769
25	True hermaphroditism (HP:0010459)	2.77365149
26	Hypoproteinemia (HP:0003075)	2.71617920
27	Increased serum lactate (HP:0002151)	2.69816643
28	Methylmalonic aciduria (HP:0012120)	2.68572075
29	Renal Fanconi syndrome (HP:0001994)	2.68078715
30	Severe combined immunodeficiency (HP:0004430)	2.66198642
31	Attenuation of retinal blood vessels (HP:0007843)	2.59347983
32	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.57951094
33	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.57140696
34	Decreased central vision (HP:0007663)	2.56934989
35	Increased intramyocellular lipid droplets (HP:0012240)	2.56162110
36	Hyperglycinemia (HP:0002154)	2.55556320
37	Abnormal rod and cone electroretinograms (HP:0008323)	2.54228673
38	Medial flaring of the eyebrow (HP:0010747)	2.53924162
39	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.52920437
40	Congenital stationary night blindness (HP:0007642)	2.52701484
41	Cerebral edema (HP:0002181)	2.52020023
42	Renal cortical cysts (HP:0000803)	2.51710609
43	Lactic acidosis (HP:0003128)	2.48161662
44	Abnormality of the renal cortex (HP:0011035)	2.42855412
45	Type II lissencephaly (HP:0007260)	2.42797174
46	Type I transferrin isoform profile (HP:0003642)	2.40400107
47	Polyuria (HP:0000103)	2.40372581
48	Abnormality of alanine metabolism (HP:0010916)	2.40360693
49	Hyperalaninemia (HP:0003348)	2.40360693
50	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.40360693
51	Abnormality of the renal medulla (HP:0100957)	2.38383602
52	Thyroiditis (HP:0100646)	2.32622571
53	Abnormality of urine glucose concentration (HP:0011016)	2.28976446
54	Glycosuria (HP:0003076)	2.28976446
55	Optic disc pallor (HP:0000543)	2.25960513
56	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.24745512
57	Elevated erythrocyte sedimentation rate (HP:0003565)	2.22241809
58	Increased muscle lipid content (HP:0009058)	2.20837863
59	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.20316429
60	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.20316429
61	Exertional dyspnea (HP:0002875)	2.18650940
62	Abnormality of vitamin B metabolism (HP:0004340)	2.18643317
63	Hypothermia (HP:0002045)	2.18151245
64	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.17076995
65	Dicarboxylic aciduria (HP:0003215)	2.14707555
66	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.14707555
67	Abnormality of the pons (HP:0007361)	2.12459138
68	Abnormality of B cell number (HP:0010975)	2.11984899
69	Abnormality of serum amino acid levels (HP:0003112)	2.09773622
70	Lethargy (HP:0001254)	2.08379990
71	Panhypogammaglobulinemia (HP:0003139)	2.08059045
72	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.05690745
73	Abnormal protein N-linked glycosylation (HP:0012347)	2.05690745
74	Abnormal protein glycosylation (HP:0012346)	2.05690745
75	Abnormal glycosylation (HP:0012345)	2.05690745
76	Progressive inability to walk (HP:0002505)	2.02343753
77	Intestinal atresia (HP:0011100)	2.00085967
78	Ketosis (HP:0001946)	1.99563525
79	B lymphocytopenia (HP:0010976)	1.97854165
80	Pendular nystagmus (HP:0012043)	1.94994975
81	Pancytopenia (HP:0001876)	1.93433482
82	Stomach cancer (HP:0012126)	1.91472240
83	Hypoplasia of the uterus (HP:0000013)	1.91446520
84	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.91084483
85	Abnormal urine output (HP:0012590)	1.90145396
86	Congenital, generalized hypertrichosis (HP:0004540)	1.89413651
87	Combined immunodeficiency (HP:0005387)	1.86805672
88	Respiratory failure (HP:0002878)	1.86350184
89	Abnormality of renal resorption (HP:0011038)	1.86213264
90	Exercise intolerance (HP:0003546)	1.84761971
91	Keratoconus (HP:0000563)	1.84531646
92	Increased corneal curvature (HP:0100692)	1.84531646
93	Congenital primary aphakia (HP:0007707)	1.84411234
94	Reduced antithrombin III activity (HP:0001976)	1.84058407
95	Aplasia/hypoplasia of the uterus (HP:0008684)	1.84008708
96	Gait imbalance (HP:0002141)	1.83395969
97	Cerebellar dysplasia (HP:0007033)	1.81018785
98	Nephrogenic diabetes insipidus (HP:0009806)	1.80906679
99	Sclerocornea (HP:0000647)	1.80046930
100	Facial diplegia (HP:0001349)	1.79891997

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	3.37298379
2	EIF2AK3	2.80128302
3	TXK	2.75015344
4	MAP4K2	2.72570914
5	FRK	2.66345078
6	STK16	2.64569991
7	MST4	2.47464196
8	NUAK1	2.35028967
9	TAOK3	2.29948333
10	BCKDK	2.28852193
11	TLK1	2.22264899
12	ADRBK2	2.19800282
13	GRK1	2.07359910
14	WNK4	2.07136406
15	WNK3	2.06287531
16	STK39	1.83596282
17	VRK2	1.72230282
18	BUB1	1.64566792
19	OXSR1	1.63117571
20	BMPR1B	1.51337567
21	TEC	1.46517164
22	MAP3K12	1.44650977
23	TIE1	1.35909038
24	PLK4	1.35566225
25	VRK1	1.35288094
26	TSSK6	1.32567350
27	PINK1	1.31304373
28	MKNK1	1.26967158
29	ITK	1.19758866
30	PBK	1.16504315
31	EIF2AK1	1.13698477
32	PLK3	1.13057744
33	INSRR	1.02582271
34	SCYL2	1.02221847
35	IKBKB	1.01414312
36	FES	1.00304060
37	TRIM28	1.00264693
38	RPS6KA5	1.00035374
39	BMPR2	0.99578663
40	PDK2	0.98887133
41	CDK19	0.96691130
42	EIF2AK2	0.93506065
43	MKNK2	0.92617504
44	PAK3	0.91825666
45	PRKCQ	0.90508649
46	ERBB3	0.88683820
47	TNK2	0.82928969
48	SRPK1	0.81962760
49	NME1	0.80562268
50	KIT	0.78914821
51	MAPK13	0.78889306
52	IKBKE	0.78834003
53	KDR	0.77963991
54	EPHA4	0.77247327
55	NEK1	0.73102121
56	SYK	0.72392864
57	CSNK1G1	0.72164764
58	PHKG1	0.71889069
59	PHKG2	0.71889069
60	PLK2	0.70652925
61	ACVR1B	0.70557118
62	MAP4K1	0.67198110
63	ATR	0.66066750
64	CSNK1G3	0.65750100
65	PASK	0.64127313
66	ADRBK1	0.60203058
67	GRK7	0.59520082
68	DYRK2	0.55829443
69	CAMKK2	0.55715777
70	RPS6KA4	0.53704050
71	OBSCN	0.53689113
72	BTK	0.53215203
73	PRKCE	0.50865943
74	LYN	0.47300339
75	PLK1	0.47225376
76	TNIK	0.47182761
77	CSNK1G2	0.47180409
78	PRKCI	0.47025370
79	LCK	0.46206619
80	MYLK	0.45633555
81	CSNK1A1L	0.45179601
82	GRK6	0.44247969
83	CSF1R	0.43969538
84	GRK5	0.43614004
85	IGF1R	0.43573926
86	MAP3K14	0.42628757
87	PRKACA	0.41723224
88	FLT3	0.41260425
89	BCR	0.41154695
90	PIK3CA	0.40697593
91	CSNK1A1	0.40592520
92	TESK2	0.39215921
93	PRKCG	0.38759591
94	LIMK1	0.38725796
95	AURKB	0.38632281
96	BLK	0.37615151
97	ABL1	0.36838913
98	PRKCA	0.36640063
99	ATM	0.35100225
100	DAPK1	0.35072200

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.99836376
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.05799306
3	Asthma_Homo sapiens_hsa05310	2.80993953
4	Protein export_Homo sapiens_hsa03060	2.56338716
5	Parkinsons disease_Homo sapiens_hsa05012	2.47762337
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.38202790
7	Allograft rejection_Homo sapiens_hsa05330	2.17455114
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.13917145
9	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.03347200
10	Caffeine metabolism_Homo sapiens_hsa00232	1.98072357
11	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.97195042
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.91898485
13	Propanoate metabolism_Homo sapiens_hsa00640	1.91345103
14	One carbon pool by folate_Homo sapiens_hsa00670	1.89236187
15	Primary immunodeficiency_Homo sapiens_hsa05340	1.87734275
16	RNA polymerase_Homo sapiens_hsa03020	1.85307463
17	Homologous recombination_Homo sapiens_hsa03440	1.83721905
18	Graft-versus-host disease_Homo sapiens_hsa05332	1.82263266
19	Ribosome_Homo sapiens_hsa03010	1.80533845
20	RNA degradation_Homo sapiens_hsa03018	1.77236740
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.72773032
22	Type I diabetes mellitus_Homo sapiens_hsa04940	1.72186570
23	Phototransduction_Homo sapiens_hsa04744	1.69119826
24	Non-homologous end-joining_Homo sapiens_hsa03450	1.66049856
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.57465327
26	Alzheimers disease_Homo sapiens_hsa05010	1.51414724
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.49709893
28	Huntingtons disease_Homo sapiens_hsa05016	1.48043510
29	Fanconi anemia pathway_Homo sapiens_hsa03460	1.44582672
30	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.37817095
31	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.36579794
32	Linoleic acid metabolism_Homo sapiens_hsa00591	1.36162751
33	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.29593287
34	Nitrogen metabolism_Homo sapiens_hsa00910	1.25690648
35	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.25094695
36	Selenocompound metabolism_Homo sapiens_hsa00450	1.25031067
37	Butanoate metabolism_Homo sapiens_hsa00650	1.24347199
38	Antigen processing and presentation_Homo sapiens_hsa04612	1.20163554
39	Peroxisome_Homo sapiens_hsa04146	1.18266912
40	Cardiac muscle contraction_Homo sapiens_hsa04260	1.15016087
41	Basal transcription factors_Homo sapiens_hsa03022	1.14670701
42	Mismatch repair_Homo sapiens_hsa03430	1.14420300
43	Fatty acid elongation_Homo sapiens_hsa00062	1.14361734
44	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.13381700
45	RNA transport_Homo sapiens_hsa03013	1.08675419
46	Rheumatoid arthritis_Homo sapiens_hsa05323	1.07974522
47	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.05748726
48	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.04368953
49	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.02280247
50	Nucleotide excision repair_Homo sapiens_hsa03420	0.93610259
51	Purine metabolism_Homo sapiens_hsa00230	0.90960406
52	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.89866112
53	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.89643402
54	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.88115762
55	Collecting duct acid secretion_Homo sapiens_hsa04966	0.87088816
56	Pyrimidine metabolism_Homo sapiens_hsa00240	0.86798351
57	Sulfur metabolism_Homo sapiens_hsa00920	0.83946302
58	Fatty acid degradation_Homo sapiens_hsa00071	0.82935113
59	Spliceosome_Homo sapiens_hsa03040	0.80638578
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.80467246
61	Retinol metabolism_Homo sapiens_hsa00830	0.77679719
62	Base excision repair_Homo sapiens_hsa03410	0.75174493
63	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.72123439
64	Olfactory transduction_Homo sapiens_hsa04740	0.71935722
65	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.71269655
66	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.70655656
67	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.70482524
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.69131712
69	Regulation of autophagy_Homo sapiens_hsa04140	0.68657263
70	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.67345977
71	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.67032241
72	Metabolic pathways_Homo sapiens_hsa01100	0.65428238
73	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.65077332
74	Ether lipid metabolism_Homo sapiens_hsa00565	0.64043226
75	DNA replication_Homo sapiens_hsa03030	0.60590988
76	Fatty acid metabolism_Homo sapiens_hsa01212	0.56902009
77	Pyruvate metabolism_Homo sapiens_hsa00620	0.53422007
78	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.53378435
79	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.53277237
80	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.53080047
81	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.52109033
82	beta-Alanine metabolism_Homo sapiens_hsa00410	0.50113528
83	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.45979975
84	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.45339322
85	Taste transduction_Homo sapiens_hsa04742	0.44204587
86	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.41736339
87	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.40992482
88	Glutathione metabolism_Homo sapiens_hsa00480	0.40374123
89	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.38665036
90	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.38278129
91	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.37452401
92	Nicotine addiction_Homo sapiens_hsa05033	0.35314113
93	Viral myocarditis_Homo sapiens_hsa05416	0.34850505
94	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.33154868
95	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.32982450
96	ABC transporters_Homo sapiens_hsa02010	0.30884311
97	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.29633731
98	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.29188604
99	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.28507994
100	p53 signaling pathway_Homo sapiens_hsa04115	0.27547215

RPL5P23

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »