RPL5P25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.70913579
2translational termination (GO:0006415)6.47232701
3ribosomal small subunit assembly (GO:0000028)6.25980647
4ATP synthesis coupled proton transport (GO:0015986)5.91073791
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.91073791
6behavioral response to nicotine (GO:0035095)5.70503324
7establishment of protein localization to mitochondrial membrane (GO:0090151)5.67276172
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.64330592
9cotranslational protein targeting to membrane (GO:0006613)5.55773647
10protein targeting to ER (GO:0045047)5.50689110
11translational elongation (GO:0006414)5.50247377
12ribosomal small subunit biogenesis (GO:0042274)5.35851612
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.32070376
14establishment of protein localization to endoplasmic reticulum (GO:0072599)5.28435406
15ribosomal large subunit biogenesis (GO:0042273)5.21217263
16protein localization to endoplasmic reticulum (GO:0070972)5.15491147
17chaperone-mediated protein transport (GO:0072321)4.97369877
18viral life cycle (GO:0019058)4.93253243
19cellular protein complex disassembly (GO:0043624)4.89436663
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.68501791
21translational initiation (GO:0006413)4.62650303
22maturation of SSU-rRNA (GO:0030490)4.61653556
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.39935071
24protein complex disassembly (GO:0043241)4.15082505
25translation (GO:0006412)4.03405540
26protein complex biogenesis (GO:0070271)4.00726522
27macromolecular complex disassembly (GO:0032984)3.96314976
28mitochondrial respiratory chain complex I assembly (GO:0032981)3.94982293
29NADH dehydrogenase complex assembly (GO:0010257)3.94982293
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.94982293
31protein neddylation (GO:0045116)3.94975779
32respiratory electron transport chain (GO:0022904)3.92680967
33electron transport chain (GO:0022900)3.89082668
34ribonucleoprotein complex biogenesis (GO:0022613)3.78976737
35mitochondrial respiratory chain complex assembly (GO:0033108)3.78707816
36tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.76935815
37RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.76935815
38positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.74212066
39protein targeting to membrane (GO:0006612)3.71989598
40cellular component biogenesis (GO:0044085)3.69621422
41GTP biosynthetic process (GO:0006183)3.57250678
42DNA deamination (GO:0045006)3.55670119
43inner mitochondrial membrane organization (GO:0007007)3.49483041
44nuclear-transcribed mRNA catabolic process (GO:0000956)3.49139118
45water-soluble vitamin biosynthetic process (GO:0042364)3.41933550
46purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.40319446
47purine nucleoside triphosphate biosynthetic process (GO:0009145)3.37443807
48ATP biosynthetic process (GO:0006754)3.34972742
49regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.33949207
50mRNA catabolic process (GO:0006402)3.31437862
51nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.28915839
52regulation of isotype switching to IgG isotypes (GO:0048302)3.25701975
53termination of RNA polymerase III transcription (GO:0006386)3.21208104
54transcription elongation from RNA polymerase III promoter (GO:0006385)3.21208104
55exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.20532979
56intracellular protein transmembrane import (GO:0044743)3.15967745
57rRNA processing (GO:0006364)3.06184790
58hydrogen ion transmembrane transport (GO:1902600)3.04293710
59RNA catabolic process (GO:0006401)3.04007363
60rRNA metabolic process (GO:0016072)3.03146522
61ribonucleoside triphosphate biosynthetic process (GO:0009201)3.00824064
62UTP biosynthetic process (GO:0006228)3.00748776
63nonmotile primary cilium assembly (GO:0035058)3.00568733
64proton transport (GO:0015992)2.90187388
65hydrogen transport (GO:0006818)2.83833233
66regulation of immunoglobulin secretion (GO:0051023)2.79215806
67DNA damage response, detection of DNA damage (GO:0042769)2.75908741
68ribosome biogenesis (GO:0042254)2.74806181
69epithelial cilium movement (GO:0003351)2.74406691
70UTP metabolic process (GO:0046051)2.72723112
71protein targeting to mitochondrion (GO:0006626)2.72173165
72establishment of protein localization to mitochondrion (GO:0072655)2.72092725
73spinal cord association neuron differentiation (GO:0021527)2.71541915
74respiratory chain complex IV assembly (GO:0008535)2.70748833
75protein localization to mitochondrion (GO:0070585)2.69168863
76protein-cofactor linkage (GO:0018065)2.67226134
77epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.66247314
78aldehyde catabolic process (GO:0046185)2.64800384
79tRNA processing (GO:0008033)2.64435632
80CTP biosynthetic process (GO:0006241)2.64379849
81CTP metabolic process (GO:0046036)2.64379849
82positive regulation of gastrulation (GO:2000543)2.62725501
83protein targeting (GO:0006605)2.62046527
84intracellular protein transmembrane transport (GO:0065002)2.61742994
85nucleoside triphosphate biosynthetic process (GO:0009142)2.60369961
86protein transmembrane transport (GO:0071806)2.59878843
87RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.59612716
88neurofilament cytoskeleton organization (GO:0060052)2.59357159
89ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.58930407
90pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.58644196
91establishment of protein localization to membrane (GO:0090150)2.56390796
92somite development (GO:0061053)2.54686767
93synaptic transmission, cholinergic (GO:0007271)2.53502823
94axonemal dynein complex assembly (GO:0070286)2.48791416
95DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.47361760
96endoderm formation (GO:0001706)2.45580681
97axoneme assembly (GO:0035082)2.44630656
98negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.44371321
99cell proliferation in forebrain (GO:0021846)2.43452753
100ncRNA processing (GO:0034470)2.42503731

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.38984565
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.87844912
3EZH2_22144423_ChIP-Seq_EOC_Human3.75434471
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.44602377
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.21841698
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.18861063
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.79037078
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.77535206
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.75648182
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.70163023
11ZNF274_21170338_ChIP-Seq_K562_Hela2.66652928
12VDR_22108803_ChIP-Seq_LS180_Human2.48473113
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.48024434
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.40762486
15VDR_23849224_ChIP-Seq_CD4+_Human2.11803715
16ELF1_17652178_ChIP-ChIP_JURKAT_Human1.97968118
17FLI1_27457419_Chip-Seq_LIVER_Mouse1.94465998
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94082883
19TTF2_22483619_ChIP-Seq_HELA_Human1.91686497
20CREB1_15753290_ChIP-ChIP_HEK293T_Human1.90525117
21FOXP3_21729870_ChIP-Seq_TREG_Human1.89841845
22ELK1_19687146_ChIP-ChIP_HELA_Human1.76535520
23EWS_26573619_Chip-Seq_HEK293_Human1.75714982
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73526985
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72953511
26TP53_22573176_ChIP-Seq_HFKS_Human1.69904998
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.67698176
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.64867605
29MYC_18940864_ChIP-ChIP_HL60_Human1.62749284
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58767887
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53745501
32MYC_19079543_ChIP-ChIP_MESCs_Mouse1.51749572
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.50822055
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.49366979
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47891813
36REST_21632747_ChIP-Seq_MESCs_Mouse1.46097179
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44431617
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43379094
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.41955245
40FUS_26573619_Chip-Seq_HEK293_Human1.40704330
41EZH2_27304074_Chip-Seq_ESCs_Mouse1.35374038
42SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.35311393
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.34568551
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33686105
45RNF2_27304074_Chip-Seq_NSC_Mouse1.33583329
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.33155193
47XRN2_22483619_ChIP-Seq_HELA_Human1.32812256
48GABP_19822575_ChIP-Seq_HepG2_Human1.32772690
49IRF1_19129219_ChIP-ChIP_H3396_Human1.29070446
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.28123477
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27056030
52GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24688660
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24513523
54REST_18959480_ChIP-ChIP_MESCs_Mouse1.21174101
55IGF1R_20145208_ChIP-Seq_DFB_Human1.19230128
56P300_19829295_ChIP-Seq_ESCs_Human1.18758945
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.16458885
58CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15602643
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.15435465
60ETV2_25802403_ChIP-Seq_MESCs_Mouse1.14927240
61TAF15_26573619_Chip-Seq_HEK293_Human1.12595213
62FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11811259
63JARID2_20064375_ChIP-Seq_MESCs_Mouse1.10799033
64KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08111603
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07982099
66ER_23166858_ChIP-Seq_MCF-7_Human1.06128429
67MYC_19030024_ChIP-ChIP_MESCs_Mouse1.06092783
68NCOR_22424771_ChIP-Seq_293T_Human1.04903451
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04707136
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04444235
71ELK1_22589737_ChIP-Seq_MCF10A_Human1.04208758
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03417711
73CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02616099
74NANOG_20526341_ChIP-Seq_ESCs_Human1.01777178
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00917161
76AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00437265
77CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99455257
78ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99396529
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99325833
80THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97780263
81SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96840690
82MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96463046
83RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95636479
84NANOG_19829295_ChIP-Seq_ESCs_Human0.95540231
85SOX2_19829295_ChIP-Seq_ESCs_Human0.95540231
86ERA_21632823_ChIP-Seq_H3396_Human0.94318424
87TAF2_19829295_ChIP-Seq_ESCs_Human0.92840054
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92284916
89FOXA1_25329375_ChIP-Seq_VCAP_Human0.92274239
90FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92274239
91DCP1A_22483619_ChIP-Seq_HELA_Human0.90797863
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89713991
93SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89601059
94SOX2_16153702_ChIP-ChIP_HESCs_Human0.89185612
95GBX2_23144817_ChIP-Seq_PC3_Human0.88647955
96CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.87365160
97GATA3_21878914_ChIP-Seq_MCF-7_Human0.87275645
98TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86943096
99EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.86311123
100SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85158923

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.58412143
2MP0009379_abnormal_foot_pigmentation3.42829522
3MP0008877_abnormal_DNA_methylation2.95062798
4MP0003787_abnormal_imprinting2.86528056
5MP0003122_maternal_imprinting2.82130657
6MP0002102_abnormal_ear_morphology2.29772826
7MP0004142_abnormal_muscle_tone2.27084019
8MP0008789_abnormal_olfactory_epithelium2.24608237
9MP0006276_abnormal_autonomic_nervous2.12448918
10MP0005394_taste/olfaction_phenotype2.11793423
11MP0005499_abnormal_olfactory_system2.11793423
12MP0004145_abnormal_muscle_electrophysio2.11075108
13MP0003121_genomic_imprinting1.98930997
14MP0004742_abnormal_vestibular_system1.95558409
15MP0002638_abnormal_pupillary_reflex1.95319227
16MP0001529_abnormal_vocalization1.91575614
17MP0003646_muscle_fatigue1.80020794
18MP0002837_dystrophic_cardiac_calcinosis1.79061258
19MP0002272_abnormal_nervous_system1.75600271
20MP0001984_abnormal_olfaction1.74383803
21MP0002938_white_spotting1.74372101
22MP0000778_abnormal_nervous_system1.73991672
23MP0001485_abnormal_pinna_reflex1.73821842
24MP0005551_abnormal_eye_electrophysiolog1.73723619
25MP0005645_abnormal_hypothalamus_physiol1.72238945
26MP0003011_delayed_dark_adaptation1.64965239
27MP0002277_abnormal_respiratory_mucosa1.64228347
28MP0001293_anophthalmia1.64166740
29MP0004885_abnormal_endolymph1.63470955
30MP0006072_abnormal_retinal_apoptosis1.62408105
31MP0003123_paternal_imprinting1.56974090
32MP0005646_abnormal_pituitary_gland1.55475817
33MP0000631_abnormal_neuroendocrine_gland1.55342658
34MP0001968_abnormal_touch/_nociception1.54695841
35MP0009046_muscle_twitch1.54572732
36MP0003880_abnormal_central_pattern1.54429961
37MP0009745_abnormal_behavioral_response1.50670465
38MP0005377_hearing/vestibular/ear_phenot1.50349601
39MP0003878_abnormal_ear_physiology1.50349601
40MP0002736_abnormal_nociception_after1.45768882
41MP0001348_abnormal_lacrimal_gland1.41525930
42MP0008872_abnormal_physiological_respon1.40065066
43MP0000049_abnormal_middle_ear1.39809062
44MP0003567_abnormal_fetal_cardiomyocyte1.37177457
45MP0004133_heterotaxia1.35645598
46MP0005167_abnormal_blood-brain_barrier1.35563244
47MP0002163_abnormal_gland_morphology1.35347499
48MP0005084_abnormal_gallbladder_morpholo1.32203224
49MP0005423_abnormal_somatic_nervous1.31614720
50MP0002557_abnormal_social/conspecific_i1.27984409
51MP0003890_abnormal_embryonic-extraembry1.27007666
52MP0002653_abnormal_ependyma_morphology1.25220593
53MP0001970_abnormal_pain_threshold1.24716355
54MP0008875_abnormal_xenobiotic_pharmacok1.24147472
55MP0002184_abnormal_innervation1.22239221
56MP0003186_abnormal_redox_activity1.22005568
57MP0008058_abnormal_DNA_repair1.21968070
58MP0000955_abnormal_spinal_cord1.19807875
59MP0002876_abnormal_thyroid_physiology1.18508963
60MP0001835_abnormal_antigen_presentation1.17528403
61MP0002733_abnormal_thermal_nociception1.15335118
62MP0001440_abnormal_grooming_behavior1.14688729
63MP0001188_hyperpigmentation1.11354913
64MP0003195_calcinosis1.08085161
65MP0002138_abnormal_hepatobiliary_system1.06354649
66MP0001986_abnormal_taste_sensitivity1.06172578
67MP0000569_abnormal_digit_pigmentation1.05697671
68MP0000372_irregular_coat_pigmentation1.05051947
69MP0000026_abnormal_inner_ear1.04164810
70MP0002067_abnormal_sensory_capabilities1.04155365
71MP0002572_abnormal_emotion/affect_behav1.04022666
72MP0002752_abnormal_somatic_nervous1.03614554
73MP0003786_premature_aging1.01914109
74MP0002160_abnormal_reproductive_system1.01899991
75MP0008995_early_reproductive_senescence1.01222764
76MP0005389_reproductive_system_phenotype1.01133696
77MP0001905_abnormal_dopamine_level1.00509312
78MP0005195_abnormal_posterior_eye0.99139903
79MP0001486_abnormal_startle_reflex0.97546144
80MP0002210_abnormal_sex_determination0.95140084
81MP0005253_abnormal_eye_physiology0.93040174
82MP0003635_abnormal_synaptic_transmissio0.92909158
83MP0010386_abnormal_urinary_bladder0.91933980
84MP0005379_endocrine/exocrine_gland_phen0.91653963
85MP0003119_abnormal_digestive_system0.91516258
86MP0001286_abnormal_eye_development0.90472955
87MP0010030_abnormal_orbit_morphology0.87031069
88MP0003959_abnormal_lean_body0.86752881
89MP0002234_abnormal_pharynx_morphology0.86193194
90MP0000427_abnormal_hair_cycle0.84747080
91MP0002064_seizures0.84688018
92MP0002063_abnormal_learning/memory/cond0.84643369
93MP0002095_abnormal_skin_pigmentation0.84487324
94MP0001963_abnormal_hearing_physiology0.84344071
95MP0002882_abnormal_neuron_morphology0.81363507
96MP0001502_abnormal_circadian_rhythm0.79946064
97MP0002735_abnormal_chemical_nociception0.79385470
98MP0005410_abnormal_fertilization0.78938952
99MP0003693_abnormal_embryo_hatching0.78449644
100MP0002734_abnormal_mechanical_nocicepti0.77313750

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.04217617
2Reticulocytopenia (HP:0001896)4.51879770
3Abnormal mitochondria in muscle tissue (HP:0008316)4.49667556
4Acute encephalopathy (HP:0006846)4.26465214
5Mitochondrial inheritance (HP:0001427)4.26019471
63-Methylglutaconic aciduria (HP:0003535)4.17906802
7Progressive macrocephaly (HP:0004481)4.12441766
8Abnormality of cells of the erythroid lineage (HP:0012130)3.92698029
9Increased CSF lactate (HP:0002490)3.80810627
10Macrocytic anemia (HP:0001972)3.65445317
11Increased hepatocellular lipid droplets (HP:0006565)3.42109149
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.31960458
13Absent/shortened dynein arms (HP:0200106)3.31960458
14Abnormal number of erythroid precursors (HP:0012131)3.31235410
15Abnormality of midbrain morphology (HP:0002418)3.22270300
16Molar tooth sign on MRI (HP:0002419)3.22270300
17Nephronophthisis (HP:0000090)3.19312453
18Hepatocellular necrosis (HP:0001404)3.10141578
19Renal Fanconi syndrome (HP:0001994)3.09040550
20Cerebral edema (HP:0002181)3.08634814
21Lipid accumulation in hepatocytes (HP:0006561)3.06808691
22Optic disc pallor (HP:0000543)2.90838933
23Pancreatic fibrosis (HP:0100732)2.86620081
24Abnormality of the labia minora (HP:0012880)2.83228572
25Pancreatic cysts (HP:0001737)2.80602803
26Hepatic necrosis (HP:0002605)2.77684997
27Septo-optic dysplasia (HP:0100842)2.73556423
28Pallor (HP:0000980)2.73392392
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.70306101
30Abnormal ciliary motility (HP:0012262)2.66096042
31Medial flaring of the eyebrow (HP:0010747)2.65783371
32Myokymia (HP:0002411)2.62891110
33Abnormality of the pons (HP:0007361)2.61695383
34Increased serum lactate (HP:0002151)2.61096422
35Absent rod-and cone-mediated responses on ERG (HP:0007688)2.59123159
36Abnormal respiratory epithelium morphology (HP:0012253)2.57908433
37Abnormal respiratory motile cilium morphology (HP:0005938)2.57908433
38Abnormality of the renal medulla (HP:0100957)2.50519648
39Chronic hepatic failure (HP:0100626)2.48544443
40Hypoplasia of the pons (HP:0012110)2.48172442
41Increased intramyocellular lipid droplets (HP:0012240)2.42322552
42Abnormal respiratory motile cilium physiology (HP:0012261)2.38400700
43Abnormal rod and cone electroretinograms (HP:0008323)2.36534851
44True hermaphroditism (HP:0010459)2.35680025
45Lactic acidosis (HP:0003128)2.32723783
46Stomatitis (HP:0010280)2.30831445
47Leukodystrophy (HP:0002415)2.28670250
48Type II lissencephaly (HP:0007260)2.27958586
49Congenital stationary night blindness (HP:0007642)2.16826190
50Supernumerary spleens (HP:0009799)2.16179409
51Aplasia/Hypoplasia of the spleen (HP:0010451)2.13864400
52Exercise intolerance (HP:0003546)2.11999352
53Pendular nystagmus (HP:0012043)2.11399042
54Growth hormone deficiency (HP:0000824)2.10873382
55Respiratory failure (HP:0002878)2.09875129
56Polyphagia (HP:0002591)2.09749731
57Exertional dyspnea (HP:0002875)2.08828989
58Elevated erythrocyte sedimentation rate (HP:0003565)2.08740924
59Gait imbalance (HP:0002141)2.07847405
60Colon cancer (HP:0003003)2.06986970
61Methylmalonic acidemia (HP:0002912)2.04849298
62Asplenia (HP:0001746)2.04359290
63Congenital, generalized hypertrichosis (HP:0004540)2.04311607
64Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.03184802
65Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01558624
66Abnormality of alanine metabolism (HP:0010916)2.01558624
67Hyperalaninemia (HP:0003348)2.01558624
68Abnormality of renal resorption (HP:0011038)2.01108784
69Abnormality of magnesium homeostasis (HP:0004921)1.99321754
70Hypomagnesemia (HP:0002917)1.99302873
71Abnormality of the renal cortex (HP:0011035)1.98765226
72Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.96724127
73Optic nerve coloboma (HP:0000588)1.96271617
74Lethargy (HP:0001254)1.96075196
75Respiratory difficulties (HP:0002880)1.95481901
76Adrenal hypoplasia (HP:0000835)1.94531727
77Rib fusion (HP:0000902)1.94191745
78Stenosis of the external auditory canal (HP:0000402)1.93652453
79Absent septum pellucidum (HP:0001331)1.93399353
80Congenital primary aphakia (HP:0007707)1.93121696
81Abolished electroretinogram (ERG) (HP:0000550)1.90618247
82Increased muscle lipid content (HP:0009058)1.89888121
83Abnormality of the aortic arch (HP:0012303)1.89443556
84Tubular atrophy (HP:0000092)1.89099812
85Absent thumb (HP:0009777)1.87742841
86Type 2 muscle fiber atrophy (HP:0003554)1.87053478
87Abnormal drinking behavior (HP:0030082)1.86334071
88Polydipsia (HP:0001959)1.86334071
89Progressive cerebellar ataxia (HP:0002073)1.86061255
90Diastasis recti (HP:0001540)1.85224824
91Shawl scrotum (HP:0000049)1.85200285
92Abnormal pancreas size (HP:0012094)1.84110558
93Agitation (HP:0000713)1.83944406
94Depressed nasal ridge (HP:0000457)1.82423694
95Oligodactyly (hands) (HP:0001180)1.81935592
96Methylmalonic aciduria (HP:0012120)1.81534114
97Optic nerve hypoplasia (HP:0000609)1.78045007
98X-linked dominant inheritance (HP:0001423)1.77739778
99Bile duct proliferation (HP:0001408)1.77493933
100Abnormal biliary tract physiology (HP:0012439)1.77493933

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.25401184
2WNK43.16569881
3VRK22.71580662
4ADRBK22.63598375
5DYRK22.54117405
6NME12.39970605
7TSSK62.39919719
8ZAK2.38376675
9TXK2.10638091
10NUAK12.01235763
11MAP4K22.01044318
12BMPR1B1.98322660
13EIF2AK11.86090082
14EPHB21.83090804
15GRK11.76517278
16WNK31.69656738
17FRK1.61982449
18MAP3K41.59765087
19VRK11.54075010
20TLK11.53918083
21PINK11.52940118
22PASK1.52078977
23EIF2AK31.48532213
24BCKDK1.47866546
25TNIK1.46532954
26MARK11.42728628
27TAOK31.27967997
28MAP2K61.26432399
29MST41.18957554
30PNCK1.18880227
31STK391.18508125
32PDK21.17996545
33MAP4K11.16970111
34TIE11.06044380
35CASK1.05712183
36MINK11.05686113
37DYRK31.01719437
38PRKCG0.99874157
39NTRK20.99619121
40MAP3K110.98381896
41LIMK10.97143022
42PBK0.96330238
43TAF10.95603135
44PLK30.92956488
45TGFBR10.92050053
46OXSR10.89568864
47TEC0.87617176
48MKNK20.84793672
49CDC70.84425726
50NTRK30.82434658
51PLK40.80303338
52CAMKK20.79611891
53NME20.79526673
54MAP2K70.78764989
55PHKG20.77743527
56PHKG10.77743527
57MAPK130.77686188
58NEK10.77528011
59INSRR0.75328161
60WNK10.75307588
61PIK3CA0.75025960
62PAK30.74755474
63ADRBK10.74383514
64MAPK150.74293184
65CSNK2A20.73508481
66PLK20.71839090
67SRPK10.68522377
68CSNK1E0.68052406
69TRIM280.67765314
70CAMK1D0.65804378
71MAP3K120.65308740
72RPS6KA60.61420444
73PLK10.60393116
74RPS6KA50.60135334
75DAPK20.59846897
76CDK190.58117349
77CAMK10.57565281
78CSNK1G20.56459827
79ITK0.55210163
80NLK0.51937104
81RPS6KA40.51072372
82ALK0.50351281
83PRKCQ0.49459778
84CSNK2A10.46915659
85PRKACA0.46442058
86CAMKK10.45663493
87CAMK2A0.45041905
88FES0.43000034
89RPS6KC10.42281336
90RPS6KL10.42281336
91PRKCI0.42207446
92DAPK30.42055864
93MKNK10.41716826
94SGK4940.41502948
95SGK2230.41502948
96GRK70.41213240
97FGFR10.41011963
98ATR0.40856854
99PRKCE0.40027399
100WEE10.39916328

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.69614624
2Oxidative phosphorylation_Homo sapiens_hsa001904.22246992
3Parkinsons disease_Homo sapiens_hsa050123.55616152
4Proteasome_Homo sapiens_hsa030503.17894552
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.75253284
6Huntingtons disease_Homo sapiens_hsa050162.64749968
7Protein export_Homo sapiens_hsa030602.59729421
8Cardiac muscle contraction_Homo sapiens_hsa042602.48812866
9RNA polymerase_Homo sapiens_hsa030202.45251655
10Alzheimers disease_Homo sapiens_hsa050102.41694330
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.24836342
12Basal transcription factors_Homo sapiens_hsa030222.13633664
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.97454382
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.86414356
15Asthma_Homo sapiens_hsa053101.83131897
16One carbon pool by folate_Homo sapiens_hsa006701.70461641
17Linoleic acid metabolism_Homo sapiens_hsa005911.70443392
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.66784182
19Homologous recombination_Homo sapiens_hsa034401.64950114
20RNA degradation_Homo sapiens_hsa030181.57573520
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57084613
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.50644540
23Butanoate metabolism_Homo sapiens_hsa006501.50534012
24Vitamin B6 metabolism_Homo sapiens_hsa007501.35019742
25Phototransduction_Homo sapiens_hsa047441.34364012
26Propanoate metabolism_Homo sapiens_hsa006401.29550556
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.26179503
28Pyrimidine metabolism_Homo sapiens_hsa002401.24171118
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.21833901
30Nicotine addiction_Homo sapiens_hsa050331.21790692
31Allograft rejection_Homo sapiens_hsa053301.12888814
32Nucleotide excision repair_Homo sapiens_hsa034201.08020843
33Mismatch repair_Homo sapiens_hsa034301.07817650
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.06526353
35Fanconi anemia pathway_Homo sapiens_hsa034601.05434693
36RNA transport_Homo sapiens_hsa030131.04951563
37Fat digestion and absorption_Homo sapiens_hsa049751.04704988
38Ether lipid metabolism_Homo sapiens_hsa005651.04240358
39Spliceosome_Homo sapiens_hsa030401.03222158
40Autoimmune thyroid disease_Homo sapiens_hsa053200.98958368
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97967012
42Sulfur relay system_Homo sapiens_hsa041220.97093503
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94460853
44Steroid biosynthesis_Homo sapiens_hsa001000.89731416
45Type I diabetes mellitus_Homo sapiens_hsa049400.88505137
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86770275
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85720834
48Sulfur metabolism_Homo sapiens_hsa009200.84955352
49Peroxisome_Homo sapiens_hsa041460.78970503
50Purine metabolism_Homo sapiens_hsa002300.77640465
51Folate biosynthesis_Homo sapiens_hsa007900.71544589
52Nitrogen metabolism_Homo sapiens_hsa009100.71426436
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.69442243
54Arachidonic acid metabolism_Homo sapiens_hsa005900.69354959
55Metabolic pathways_Homo sapiens_hsa011000.66591540
56Base excision repair_Homo sapiens_hsa034100.64953159
57Regulation of autophagy_Homo sapiens_hsa041400.64576194
58Pyruvate metabolism_Homo sapiens_hsa006200.62510738
59DNA replication_Homo sapiens_hsa030300.62379127
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61101074
61Caffeine metabolism_Homo sapiens_hsa002320.59706410
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59392028
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59210811
64Insulin secretion_Homo sapiens_hsa049110.58235084
65Collecting duct acid secretion_Homo sapiens_hsa049660.57792156
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.57560226
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56063144
68Tryptophan metabolism_Homo sapiens_hsa003800.55252535
69Olfactory transduction_Homo sapiens_hsa047400.54049450
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53822296
71Non-homologous end-joining_Homo sapiens_hsa034500.51270556
72Morphine addiction_Homo sapiens_hsa050320.50437929
73Retinol metabolism_Homo sapiens_hsa008300.49729553
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49122335
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47938640
76Primary immunodeficiency_Homo sapiens_hsa053400.47826943
77Chemical carcinogenesis_Homo sapiens_hsa052040.47147973
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.44394386
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41767668
80Ovarian steroidogenesis_Homo sapiens_hsa049130.41261995
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40848301
82Graft-versus-host disease_Homo sapiens_hsa053320.40663268
83Rheumatoid arthritis_Homo sapiens_hsa053230.39705374
84GABAergic synapse_Homo sapiens_hsa047270.38852279
85Fatty acid degradation_Homo sapiens_hsa000710.37054367
86Taste transduction_Homo sapiens_hsa047420.33410461
87Fatty acid biosynthesis_Homo sapiens_hsa000610.32535167
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31315379
89Selenocompound metabolism_Homo sapiens_hsa004500.30595420
90Mineral absorption_Homo sapiens_hsa049780.28131227
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.25268857
92Glutamatergic synapse_Homo sapiens_hsa047240.25227256
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24237419
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22953335
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19419223
96Hematopoietic cell lineage_Homo sapiens_hsa046400.19169367
97beta-Alanine metabolism_Homo sapiens_hsa004100.18020756
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.15551724
99Glycerolipid metabolism_Homo sapiens_hsa005610.15170178
100Serotonergic synapse_Homo sapiens_hsa047260.14271924

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »