RPL5P26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous antigen (GO:0019883)9.99425250
2intra-S DNA damage checkpoint (GO:0031573)7.52352957
3dopamine transport (GO:0015872)6.04901561
4heart trabecula morphogenesis (GO:0061384)5.93360421
5viral transcription (GO:0019083)5.79781007
6mRNA splice site selection (GO:0006376)5.56270721
7translational termination (GO:0006415)5.54094463
8translational elongation (GO:0006414)4.94244321
9transmission of nerve impulse (GO:0019226)4.87941127
10DNA integration (GO:0015074)4.86774017
11nonmotile primary cilium assembly (GO:0035058)4.82733166
12ribosomal small subunit assembly (GO:0000028)4.81259816
13DNA replication checkpoint (GO:0000076)4.76799482
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.70188935
15skeletal muscle tissue regeneration (GO:0043403)4.68987023
16trabecula morphogenesis (GO:0061383)4.60117509
17cotranslational protein targeting to membrane (GO:0006613)4.59913191
18protein targeting to ER (GO:0045047)4.54337895
19protein localization to endoplasmic reticulum (GO:0070972)4.38678269
20establishment of protein localization to endoplasmic reticulum (GO:0072599)4.34540680
21cellular protein complex disassembly (GO:0043624)4.18736237
22ribosomal small subunit biogenesis (GO:0042274)4.09020026
23viral life cycle (GO:0019058)4.08236397
24water-soluble vitamin biosynthetic process (GO:0042364)3.97331943
25nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.91426874
26positive regulation of protein kinase C signaling (GO:0090037)3.89067655
27branched-chain amino acid catabolic process (GO:0009083)3.86588942
28positive regulation of fatty acid transport (GO:2000193)3.84930308
29catecholamine transport (GO:0051937)3.80000490
30behavioral response to nicotine (GO:0035095)3.75721425
31positive regulation of icosanoid secretion (GO:0032305)3.63414130
32translational initiation (GO:0006413)3.62864857
33trophectodermal cell differentiation (GO:0001829)3.59166268
34male meiosis I (GO:0007141)3.59138687
35synapsis (GO:0007129)3.55350832
36positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.54015788
37positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.52609203
38protein complex disassembly (GO:0043241)3.52233644
39diol metabolic process (GO:0034311)3.43081507
40DNA-dependent DNA replication (GO:0006261)3.40261377
41macromolecular complex disassembly (GO:0032984)3.34727139
42epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.28300133
43branched-chain amino acid metabolic process (GO:0009081)3.26821532
44mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.25312331
45mitochondrial respiratory chain complex I assembly (GO:0032981)3.25312331
46NADH dehydrogenase complex assembly (GO:0010257)3.25312331
47translation (GO:0006412)3.24933292
48urinary tract smooth muscle contraction (GO:0014848)3.19122128
49reciprocal DNA recombination (GO:0035825)3.18746205
50reciprocal meiotic recombination (GO:0007131)3.18746205
51DNA strand renaturation (GO:0000733)3.16710486
52olfactory bulb development (GO:0021772)3.16683182
53chaperone-mediated protein transport (GO:0072321)3.13650598
54base-excision repair, AP site formation (GO:0006285)3.11756466
55ribosomal large subunit biogenesis (GO:0042273)3.07125832
56mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.05686468
57protein targeting to membrane (GO:0006612)3.04321778
58ATP synthesis coupled proton transport (GO:0015986)3.03512264
59energy coupled proton transport, down electrochemical gradient (GO:0015985)3.03512264
60calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.02473016
61neuron remodeling (GO:0016322)3.01348367
62phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.00510584
63RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.97949524
64tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.97949524
65substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.97721209
66substrate-independent telencephalic tangential migration (GO:0021826)2.97721209
67regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.96213890
68protein complex biogenesis (GO:0070271)2.96010137
69negative regulation of striated muscle cell apoptotic process (GO:0010664)2.95478440
70regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.94308683
71establishment of protein localization to mitochondrial membrane (GO:0090151)2.92278120
72L-serine metabolic process (GO:0006563)2.91628699
73meiosis I (GO:0007127)2.86702335
74response to folic acid (GO:0051593)2.86612351
75sphingoid metabolic process (GO:0046519)2.86531332
76GTP biosynthetic process (GO:0006183)2.84665861
77negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.80214504
78positive regulation of skeletal muscle tissue development (GO:0048643)2.76801677
79regulation of immunoglobulin secretion (GO:0051023)2.76223609
80mitochondrial respiratory chain complex assembly (GO:0033108)2.74872228
81regulation of isotype switching to IgG isotypes (GO:0048302)2.74388760
82nuclear-transcribed mRNA catabolic process (GO:0000956)2.71580280
83cellular component biogenesis (GO:0044085)2.70982449
84blood vessel maturation (GO:0001955)2.67670591
85ribonucleoprotein complex biogenesis (GO:0022613)2.66410438
86pattern specification involved in kidney development (GO:0061004)2.59120989
87regulation of nuclear cell cycle DNA replication (GO:0033262)2.56236816
88mRNA catabolic process (GO:0006402)2.54097984
89UTP biosynthetic process (GO:0006228)2.53122477
90monoamine transport (GO:0015844)2.53065101
91regulation of icosanoid secretion (GO:0032303)2.52709079
92mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.52086073
93negative regulation of B cell apoptotic process (GO:0002903)2.51759749
94cytochrome complex assembly (GO:0017004)2.51334132
95phosphatidylcholine acyl-chain remodeling (GO:0036151)2.48856950
96rRNA processing (GO:0006364)2.48510606
97G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.46310796
98maturation of SSU-rRNA (GO:0030490)13.4037102
99antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)13.2243651
100antigen processing and presentation of endogenous peptide antigen (GO:0002483)12.0765695

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.51608335
2EZH2_22144423_ChIP-Seq_EOC_Human5.12561809
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.49398819
4VDR_22108803_ChIP-Seq_LS180_Human3.02320873
5ZNF274_21170338_ChIP-Seq_K562_Hela2.90275912
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.87809395
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.79325129
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.76375399
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.36856191
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.35071253
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.30024489
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.24459252
13TP53_22573176_ChIP-Seq_HFKS_Human2.15411008
14PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.10804600
15VDR_23849224_ChIP-Seq_CD4+_Human2.02532374
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.02419609
17EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.97128749
18SOX2_18555785_ChIP-Seq_MESCs_Mouse1.96437660
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95525682
20EWS_26573619_Chip-Seq_HEK293_Human1.94870758
21MYC_18940864_ChIP-ChIP_HL60_Human1.83622178
22NOTCH1_21737748_ChIP-Seq_TLL_Human1.78740340
23ELK1_19687146_ChIP-ChIP_HELA_Human1.77131718
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.71389596
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70516054
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.70086250
27FUS_26573619_Chip-Seq_HEK293_Human1.66931335
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.65462077
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.56920221
30CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.48815026
31ERA_21632823_ChIP-Seq_H3396_Human1.47352152
32ETV2_25802403_ChIP-Seq_MESCs_Mouse1.45426216
33CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.44965582
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.42807780
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.41539232
36P300_19829295_ChIP-Seq_ESCs_Human1.39715790
37EGR1_23403033_ChIP-Seq_LIVER_Mouse1.33801400
38YY1_22570637_ChIP-Seq_MALME-3M_Human1.33767050
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.33381918
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30339346
41AR_20517297_ChIP-Seq_VCAP_Human1.26804425
42IRF1_19129219_ChIP-ChIP_H3396_Human1.26519431
43GATA3_21878914_ChIP-Seq_MCF-7_Human1.23986661
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23026097
45BCAT_22108803_ChIP-Seq_LS180_Human1.20790285
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.19319342
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19064883
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.14544328
49TAF2_19829295_ChIP-Seq_ESCs_Human1.13212424
50TTF2_22483619_ChIP-Seq_HELA_Human1.13207600
51REST_18959480_ChIP-ChIP_MESCs_Mouse1.12993727
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.12470519
53CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12356211
54XRN2_22483619_ChIP-Seq_HELA_Human1.11632895
55NANOG_20526341_ChIP-Seq_ESCs_Human1.10191688
56MYC_19829295_ChIP-Seq_ESCs_Human1.10046667
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09997003
58GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09133351
59E2F4_17652178_ChIP-ChIP_JURKAT_Human1.08998413
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08290177
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06811277
62P53_21459846_ChIP-Seq_SAOS-2_Human1.05747196
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04983635
64IGF1R_20145208_ChIP-Seq_DFB_Human1.04250747
65GATA3_21867929_ChIP-Seq_TH1_Mouse1.03393059
66CTCF_20526341_ChIP-Seq_ESCs_Human1.03109082
67EZH2_27304074_Chip-Seq_ESCs_Mouse1.02408079
68EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02108094
69GATA1_26923725_Chip-Seq_HPCs_Mouse1.00049662
70FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98549867
71FOXA1_25329375_ChIP-Seq_VCAP_Human0.98549867
72POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97367899
73FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97256878
74RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.97113130
75FOXH1_21741376_ChIP-Seq_EPCs_Human0.94645353
76NANOG_19829295_ChIP-Seq_ESCs_Human0.94332442
77SOX2_19829295_ChIP-Seq_ESCs_Human0.94332442
78FOXP3_21729870_ChIP-Seq_TREG_Human0.94247393
79EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93613883
80ERG_21242973_ChIP-ChIP_JURKAT_Human0.92511754
81NCOR_22424771_ChIP-Seq_293T_Human0.91619923
82SUZ12_27294783_Chip-Seq_ESCs_Mouse0.91339988
83SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91318656
84ER_23166858_ChIP-Seq_MCF-7_Human0.91137899
85JARID2_20064375_ChIP-Seq_MESCs_Mouse0.90461008
86TP53_16413492_ChIP-PET_HCT116_Human0.90017620
87REST_21632747_ChIP-Seq_MESCs_Mouse0.87692668
88GABP_19822575_ChIP-Seq_HepG2_Human0.87535089
89KLF5_20875108_ChIP-Seq_MESCs_Mouse0.87206984
90RNF2_27304074_Chip-Seq_NSC_Mouse0.86725828
91NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.86339676
92P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86178766
93GBX2_23144817_ChIP-Seq_PC3_Human0.85509651
94ERG_20517297_ChIP-Seq_VCAP_Human0.85037293
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85009343
96TP53_18474530_ChIP-ChIP_U2OS_Human0.84001383
97ESR1_20079471_ChIP-ChIP_T-47D_Human0.82867286
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82579846
99PIAS1_25552417_ChIP-Seq_VCAP_Human0.80878403
100CBP_20019798_ChIP-Seq_JUKART_Human0.80377158

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.47578284
2MP0001529_abnormal_vocalization5.14854605
3MP0002138_abnormal_hepatobiliary_system4.63879462
4MP0003195_calcinosis4.01451372
5MP0006292_abnormal_olfactory_placode4.01406993
6MP0003567_abnormal_fetal_cardiomyocyte3.24409347
7MP0009379_abnormal_foot_pigmentation2.88764993
8MP0001348_abnormal_lacrimal_gland2.71996353
9MP0004147_increased_porphyrin_level2.55423055
10MP0002102_abnormal_ear_morphology2.31264223
11MP0006054_spinal_hemorrhage2.20328687
12MP0001986_abnormal_taste_sensitivity2.08143774
13MP0001984_abnormal_olfaction2.07991436
14MP0003136_yellow_coat_color1.95567253
15MP0004145_abnormal_muscle_electrophysio1.89503595
16MP0002160_abnormal_reproductive_system1.84072127
17MP0004142_abnormal_muscle_tone1.79566930
18MP0004885_abnormal_endolymph1.77766519
19MP0008875_abnormal_xenobiotic_pharmacok1.76112957
20MP0006072_abnormal_retinal_apoptosis1.73873296
21MP0008789_abnormal_olfactory_epithelium1.71694277
22MP0010234_abnormal_vibrissa_follicle1.65283364
23MP0002163_abnormal_gland_morphology1.60175077
24MP0010094_abnormal_chromosome_stability1.49294893
25MP0005551_abnormal_eye_electrophysiolog1.48043986
26MP0005310_abnormal_salivary_gland1.44357035
27MP0003936_abnormal_reproductive_system1.40708412
28MP0000462_abnormal_digestive_system1.39853638
29MP0003646_muscle_fatigue1.39511831
30MP0005394_taste/olfaction_phenotype1.38900195
31MP0005499_abnormal_olfactory_system1.38900195
32MP0008872_abnormal_physiological_respon1.38381021
33MP0000613_abnormal_salivary_gland1.36343167
34MP0003011_delayed_dark_adaptation1.35117454
35MP0005360_urolithiasis1.34406667
36MP0006276_abnormal_autonomic_nervous1.32535850
37MP0005389_reproductive_system_phenotype1.31817812
38MP0008877_abnormal_DNA_methylation1.31415985
39MP0000750_abnormal_muscle_regeneration1.30332758
40MP0001968_abnormal_touch/_nociception1.26336913
41MP0005671_abnormal_response_to1.25321265
42MP0002736_abnormal_nociception_after1.23346078
43MP0002557_abnormal_social/conspecific_i1.18310574
44MP0003879_abnormal_hair_cell1.17211542
45MP0001293_anophthalmia1.16992861
46MP0003283_abnormal_digestive_organ1.16092122
47MP0006035_abnormal_mitochondrial_morpho1.15087468
48MP0003878_abnormal_ear_physiology1.12460317
49MP0005377_hearing/vestibular/ear_phenot1.12460317
50MP0002837_dystrophic_cardiac_calcinosis1.11516650
51MP0000627_abnormal_mammary_gland1.09305760
52MP0001970_abnormal_pain_threshold1.07637907
53MP0002653_abnormal_ependyma_morphology1.05023457
54MP0004924_abnormal_behavior1.04165382
55MP0005386_behavior/neurological_phenoty1.04165382
56MP0001440_abnormal_grooming_behavior1.03535483
57MP0000372_irregular_coat_pigmentation1.02713534
58MP0003252_abnormal_bile_duct1.00187217
59MP0002733_abnormal_thermal_nociception0.99016043
60MP0001119_abnormal_female_reproductive0.96914156
61MP0003183_abnormal_peptide_metabolism0.96680145
62MP0002234_abnormal_pharynx_morphology0.95595157
63MP0002210_abnormal_sex_determination0.94866106
64MP0002272_abnormal_nervous_system0.94505050
65MP0001485_abnormal_pinna_reflex0.93065246
66MP0004133_heterotaxia0.91855684
67MP0009745_abnormal_behavioral_response0.91575798
68MP0004742_abnormal_vestibular_system0.91461622
69MP0005410_abnormal_fertilization0.91363384
70MP0000049_abnormal_middle_ear0.90720484
71MP0001800_abnormal_humoral_immune0.84257605
72MP0003718_maternal_effect0.83767030
73MP0005423_abnormal_somatic_nervous0.83524777
74MP0002928_abnormal_bile_duct0.82706761
75MP0001905_abnormal_dopamine_level0.80743291
76MP0005253_abnormal_eye_physiology0.80465297
77MP0002734_abnormal_mechanical_nocicepti0.80350151
78MP0002938_white_spotting0.77304597
79MP0001919_abnormal_reproductive_system0.76408605
80MP0008058_abnormal_DNA_repair0.76145354
81MP0003806_abnormal_nucleotide_metabolis0.75414803
82MP0005195_abnormal_posterior_eye0.74496781
83MP0005379_endocrine/exocrine_gland_phen0.74352750
84MP0001663_abnormal_digestive_system0.73775523
85MP0005084_abnormal_gallbladder_morpholo0.72817764
86MP0000631_abnormal_neuroendocrine_gland0.72135226
87MP0003890_abnormal_embryonic-extraembry0.71817357
88MP0005332_abnormal_amino_acid0.71623425
89MP0001145_abnormal_male_reproductive0.70645060
90MP0002638_abnormal_pupillary_reflex0.69711291
91MP0003698_abnormal_male_reproductive0.68932632
92MP0003880_abnormal_central_pattern0.68687301
93MP0001764_abnormal_homeostasis0.68384695
94MP0005645_abnormal_hypothalamus_physiol0.68302758
95MP0002752_abnormal_somatic_nervous0.68278583
96MP0003635_abnormal_synaptic_transmissio0.68041202
97MP0003787_abnormal_imprinting0.66999599
98MP0000653_abnormal_sex_gland0.64989288
99MP0002452_abnormal_antigen_presenting0.62251197
100MP0000778_abnormal_nervous_system0.62188357

Predicted human phenotypes

RankGene SetZ-score
1Nasal polyposis (HP:0100582)9.86464904
2Chronic sinusitis (HP:0011109)8.93607675
3Abnormality of the nasal mucosa (HP:0000433)8.17992861
4Hypothermia (HP:0002045)6.95931324
5Recurrent bronchitis (HP:0002837)6.74646780
6Abnormal rod and cone electroretinograms (HP:0008323)5.07107256
7Absent rod-and cone-mediated responses on ERG (HP:0007688)4.97938685
8Bronchitis (HP:0012387)4.44107341
9Bony spicule pigmentary retinopathy (HP:0007737)3.51227967
10Bronchiectasis (HP:0002110)3.25875753
11Ectopia lentis (HP:0001083)3.14936986
12Enlarged epiphyses (HP:0010580)3.06703969
13Impulsivity (HP:0100710)2.94844341
14Acute necrotizing encephalopathy (HP:0006965)2.87575324
15Emphysema (HP:0002097)2.85602958
16Medial flaring of the eyebrow (HP:0010747)2.84938571
17Colon cancer (HP:0003003)2.82050436
18Exotropia (HP:0000577)2.71994266
19Abnormality of cells of the erythroid lineage (HP:0012130)2.70917614
20Reticulocytopenia (HP:0001896)2.69741617
21Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.56120980
22Abnormality of alanine metabolism (HP:0010916)2.56120980
23Hyperalaninemia (HP:0003348)2.56120980
24Gait imbalance (HP:0002141)2.54880450
25Septo-optic dysplasia (HP:0100842)2.51962734
26Abolished electroretinogram (ERG) (HP:0000550)2.50464891
27Congenital primary aphakia (HP:0007707)2.42908035
28Deep palmar crease (HP:0006191)2.38809063
29Progressive macrocephaly (HP:0004481)2.38247365
30Abnormality of midbrain morphology (HP:0002418)2.36477278
31Molar tooth sign on MRI (HP:0002419)2.36477278
32Thyroid-stimulating hormone excess (HP:0002925)2.33893968
33Constricted visual fields (HP:0001133)2.33647104
34Abnormal mitochondria in muscle tissue (HP:0008316)2.31777799
35Decreased central vision (HP:0007663)2.29784976
36Acute encephalopathy (HP:0006846)2.29503198
37Abnormal number of erythroid precursors (HP:0012131)2.28880611
38Attenuation of retinal blood vessels (HP:0007843)2.27217517
39Nephrogenic diabetes insipidus (HP:0009806)2.22973291
40Clumsiness (HP:0002312)2.21587495
41Congenital stationary night blindness (HP:0007642)2.21366631
42Thickened helices (HP:0000391)2.20419210
43Pustule (HP:0200039)2.16755643
44Abnormality of the epiphysis of the femoral head (HP:0010574)2.16301039
45Mitochondrial inheritance (HP:0001427)2.11701948
46Alveolar cell carcinoma (HP:0006519)2.11551172
47Flattened epiphyses (HP:0003071)2.08019504
48Increased CSF lactate (HP:0002490)2.07046319
49Hepatocellular necrosis (HP:0001404)2.04098312
50Chronic otitis media (HP:0000389)13.7297765
51Abnormality of the femoral head (HP:0003368)1.95441890
52Absent thumb (HP:0009777)1.94748446
53Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.93988476
54Abnormality of femoral epiphyses (HP:0006499)1.93988476
55Thick nail (HP:0001805)1.92920010
56Abnormal respiratory motile cilium morphology (HP:0005938)1.92310804
57Abnormal respiratory epithelium morphology (HP:0012253)1.92310804
58Macrocytic anemia (HP:0001972)1.92222033
59Amelogenesis imperfecta (HP:0000705)1.88266555
60Nephronophthisis (HP:0000090)1.87905633
61Vaginal atresia (HP:0000148)1.87710935
62Type II lissencephaly (HP:0007260)1.86989073
63Hypophosphatemic rickets (HP:0004912)1.84429795
64Agammaglobulinemia (HP:0004432)1.83967526
65Abnormality of the vertebral endplates (HP:0005106)1.83672849
66Lethargy (HP:0001254)1.83332869
67Optic disc pallor (HP:0000543)1.82305633
68Genital tract atresia (HP:0001827)1.80528199
69Recurrent bacterial skin infections (HP:0005406)1.79534761
70Neoplasm of the tracheobronchial system (HP:0100552)1.77024229
71Absent/shortened dynein arms (HP:0200106)1.76078635
72Dynein arm defect of respiratory motile cilia (HP:0012255)1.76078635
73Pancreatic fibrosis (HP:0100732)1.75143905
74Slow-growing hair (HP:0002217)1.74526409
75Abnormality of hair growth rate (HP:0011363)1.74526409
76Cerebral edema (HP:0002181)1.74496911
77Maternal diabetes (HP:0009800)1.72977001
78Premature loss of primary teeth (HP:0006323)1.70619940
79Poor coordination (HP:0002370)1.68027346
80Fibular aplasia (HP:0002990)1.67892392
81Global brain atrophy (HP:0002283)1.67611882
82Abnormal ciliary motility (HP:0012262)1.65764541
83Hepatic necrosis (HP:0002605)1.64597798
84Lipid accumulation in hepatocytes (HP:0006561)1.64566276
85Increased hepatocellular lipid droplets (HP:0006565)1.60311685
86Hypoplasia of the radius (HP:0002984)1.58930142
87Generalized amyotrophy (HP:0003700)1.56763854
8811 pairs of ribs (HP:0000878)1.56093947
89Supernumerary spleens (HP:0009799)1.52163362
90Renal Fanconi syndrome (HP:0001994)1.51335936
91Long palpebral fissure (HP:0000637)1.51173110
92Pancreatic cysts (HP:0001737)1.51082499
93Retinitis pigmentosa (HP:0000510)1.49297256
94True hermaphroditism (HP:0010459)1.47382923
95Abnormal drinking behavior (HP:0030082)1.47377182
96Polydipsia (HP:0001959)1.47377182
97Hyperglycinemia (HP:0002154)1.47264550
98Abnormality of the labia minora (HP:0012880)1.46329145
99Abnormality of the renal medulla (HP:0100957)1.44839855
100Abnormal respiratory motile cilium physiology (HP:0012261)1.44413538

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK15.37512905
2ARAF4.17059978
3MAP3K94.13649359
4TAOK33.22251971
5BRAF2.89399935
6BMPR22.20090468
7MAP3K142.16661463
8MAP4K22.05868081
9MAP3K1310.8287335
10TXK1.90176029
11MOS1.83126882
12WNK41.41531350
13ZAK1.32045648
14CASK1.15597214
15ILK1.13645673
16STK390.99742625
17NEK20.98773953
18KSR10.97004699
19MAP3K80.96885880
20ADRBK20.94359204
21NEK10.93189630
22DYRK20.90136821
23STK38L0.89038313
24KSR20.87860232
25GRK10.86690822
26TSSK60.84573208
27WNK30.83421638
28MAP3K70.83054844
29BMPR1B0.80322430
30IKBKB0.79226881
31TNIK0.78932653
32MARK10.78393712
33MAP3K120.77353075
34EPHA20.75735520
35BCKDK0.74286861
36MAPK130.73225260
37RAF10.72357689
38STK160.70690182
39CHUK0.68104739
40EIF2AK10.65746150
41PLK40.65225912
42FRK0.59885890
43PRKCQ0.57755627
44MKNK20.55464185
45STK30.54186334
46PINK10.54071562
47TIE10.53240395
48TRIM280.52439932
49BTK0.52095039
50MST40.49684875
51NTRK20.46182692
52MAP3K40.45729378
53CDC70.45723652
54OXSR10.45336146
55PBK0.43920249
56TAF10.42879089
57ACVR1B0.42365791
58MAP4K10.42262343
59DAPK30.39810030
60PLK10.39779151
61TESK10.39054271
62ATR0.37899013
63TEC0.36706473
64TGFBR10.35664263
65MAP2K20.34461815
66PIM20.31545002
67NUAK10.30956292
68INSRR0.30647659
69DAPK20.30582614
70PLK30.30153230
71PAK30.29996046
72PRKCG0.29762378
73MINK10.29567140
74NME10.28019694
75EIF2AK20.27302332
76PRKAA20.27120774
77HCK0.25461377
78CSNK2A10.25386765
79FES0.25276907
80CDK140.24215564
81AURKB0.23780800
82VRK20.23341640
83PHKG20.22735049
84PHKG10.22735049
85SGK10.21349529
86CSNK2A20.20472503
87OBSCN0.18310091
88PRKCZ0.18308288
89PASK0.17782368
90ADRBK10.17304512
91VRK10.17199844
92PRKACA0.15942702
93CHEK10.15405801
94IGF1R0.14839359
95MKNK10.14732077
96STK380.14006395
97ATM0.13365814
98LYN0.12666924
99CDK180.11330524
100MYLK0.11313939

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.46382773
2Linoleic acid metabolism_Homo sapiens_hsa005913.38288392
3Oxidative phosphorylation_Homo sapiens_hsa001903.34047064
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.27468703
5Parkinsons disease_Homo sapiens_hsa050122.69463985
6Homologous recombination_Homo sapiens_hsa034402.62158617
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.19962371
8Fatty acid degradation_Homo sapiens_hsa000712.16779910
9Proteasome_Homo sapiens_hsa030502.13891610
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.10441364
11Antigen processing and presentation_Homo sapiens_hsa046121.93887844
12Asthma_Homo sapiens_hsa053101.91293837
13Nitrogen metabolism_Homo sapiens_hsa009101.90310324
14Huntingtons disease_Homo sapiens_hsa050161.87679986
15Basal transcription factors_Homo sapiens_hsa030221.80104944
16Collecting duct acid secretion_Homo sapiens_hsa049661.74954446
17Cardiac muscle contraction_Homo sapiens_hsa042601.68321482
18Allograft rejection_Homo sapiens_hsa053301.60988836
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.60117664
20Autoimmune thyroid disease_Homo sapiens_hsa053201.55995673
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.55753191
22Phototransduction_Homo sapiens_hsa047441.54367160
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.47884576
24Alzheimers disease_Homo sapiens_hsa050101.47485212
25Fatty acid metabolism_Homo sapiens_hsa012121.46939866
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46647419
27RNA degradation_Homo sapiens_hsa030181.46628723
28Ether lipid metabolism_Homo sapiens_hsa005651.45858495
29Arachidonic acid metabolism_Homo sapiens_hsa005901.41288658
30RNA polymerase_Homo sapiens_hsa030201.39646219
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.38816106
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38593315
33Olfactory transduction_Homo sapiens_hsa047401.28462817
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24835061
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22422918
36Type I diabetes mellitus_Homo sapiens_hsa049401.21579715
37Nicotine addiction_Homo sapiens_hsa050331.19381661
38Propanoate metabolism_Homo sapiens_hsa006401.13471176
39Fanconi anemia pathway_Homo sapiens_hsa034601.10609384
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08925400
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05265102
42Graft-versus-host disease_Homo sapiens_hsa053321.02736560
43Fat digestion and absorption_Homo sapiens_hsa049751.00958757
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99925824
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99802416
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.97751313
47T cell receptor signaling pathway_Homo sapiens_hsa046600.95604926
48One carbon pool by folate_Homo sapiens_hsa006700.93772005
49Caffeine metabolism_Homo sapiens_hsa002320.88184442
50Protein export_Homo sapiens_hsa030600.83570050
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81132710
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.79478246
53Retinol metabolism_Homo sapiens_hsa008300.72356952
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70285021
55Pyrimidine metabolism_Homo sapiens_hsa002400.67185699
56Regulation of autophagy_Homo sapiens_hsa041400.66740711
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66299154
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65551324
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60965502
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60776489
61Spliceosome_Homo sapiens_hsa030400.59666748
62Apoptosis_Homo sapiens_hsa042100.58439493
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58133919
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56185738
65Metabolic pathways_Homo sapiens_hsa011000.53849969
66Mismatch repair_Homo sapiens_hsa034300.52698661
67Chemical carcinogenesis_Homo sapiens_hsa052040.52443684
68Tryptophan metabolism_Homo sapiens_hsa003800.51595937
69Mineral absorption_Homo sapiens_hsa049780.51520792
70Insulin secretion_Homo sapiens_hsa049110.51033068
71Butanoate metabolism_Homo sapiens_hsa006500.50877323
72Hedgehog signaling pathway_Homo sapiens_hsa043400.50824269
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.47616818
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.45093170
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42721875
76Taste transduction_Homo sapiens_hsa047420.37652855
77Rheumatoid arthritis_Homo sapiens_hsa053230.37011636
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34918016
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.34906284
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34703218
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.34623174
82Steroid biosynthesis_Homo sapiens_hsa001000.33718875
83Purine metabolism_Homo sapiens_hsa002300.33391949
84Peroxisome_Homo sapiens_hsa041460.30886370
85Systemic lupus erythematosus_Homo sapiens_hsa053220.30805491
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30554825
87Type II diabetes mellitus_Homo sapiens_hsa049300.27881548
88Pyruvate metabolism_Homo sapiens_hsa006200.27084694
89RNA transport_Homo sapiens_hsa030130.26251290
90Thyroid cancer_Homo sapiens_hsa052160.25827117
91Hematopoietic cell lineage_Homo sapiens_hsa046400.24568103
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23527651
93p53 signaling pathway_Homo sapiens_hsa041150.23506223
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.22902620
95Hippo signaling pathway_Homo sapiens_hsa043900.21749267
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19070402
97Primary immunodeficiency_Homo sapiens_hsa053400.16547734
98Base excision repair_Homo sapiens_hsa034100.15463743
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.14009533
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.12992404

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