ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	4.97757556
2	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	4.83487360
3	positive regulation of response to tumor cell (GO:0002836)	4.58254886
4	positive regulation of immune response to tumor cell (GO:0002839)	4.58254886
5	regulation of immune response to tumor cell (GO:0002837)	4.58254886
6	regulation of response to tumor cell (GO:0002834)	4.58254886
7	ribosomal large subunit biogenesis (GO:0042273)	4.55738106
8	water-soluble vitamin biosynthetic process (GO:0042364)	4.24339087
9	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	4.23703391
10	regulation of isotype switching to IgG isotypes (GO:0048302)	4.22116613
11	proline biosynthetic process (GO:0006561)	4.00587254
12	chaperone-mediated protein transport (GO:0072321)	3.76322199
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.74972380
14	ATP synthesis coupled proton transport (GO:0015986)	3.74972380
15	protein complex biogenesis (GO:0070271)	3.72637224
16	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.66395331
17	NADH dehydrogenase complex assembly (GO:0010257)	3.66395331
18	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.66395331
19	ncRNA catabolic process (GO:0034661)	3.60768572
20	viral transcription (GO:0019083)	3.57129668
21	protein-cofactor linkage (GO:0018065)	3.48481872
22	ribosome assembly (GO:0042255)	3.46155108
23	DNA deamination (GO:0045006)	3.46141713
24	respiratory chain complex IV assembly (GO:0008535)	3.45908985
25	mitochondrial respiratory chain complex assembly (GO:0033108)	3.45858294
26	translational termination (GO:0006415)	3.44961264
27	proteasome assembly (GO:0043248)	3.36727921
28	ubiquinone biosynthetic process (GO:0006744)	3.34766704
29	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.31772643
30	urate metabolic process (GO:0046415)	3.29095038
31	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.28030055
32	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.27431306
33	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.26209823
34	rRNA modification (GO:0000154)	3.26034759
35	purine nucleotide salvage (GO:0032261)	3.20098905
36	maturation of SSU-rRNA (GO:0030490)	3.18175555
37	translational elongation (GO:0006414)	3.17105821
38	cotranslational protein targeting to membrane (GO:0006613)	3.16597951
39	protein targeting to ER (GO:0045047)	3.11500340
40	rRNA catabolic process (GO:0016075)	3.11164894
41	ribosomal small subunit biogenesis (GO:0042274)	3.10288851
42	ubiquinone metabolic process (GO:0006743)	3.07212658
43	termination of RNA polymerase III transcription (GO:0006386)	3.06746207
44	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.06746207
45	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.06301826
46	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.00207149
47	positive regulation of activated T cell proliferation (GO:0042104)	2.99633161
48	cytochrome complex assembly (GO:0017004)	2.99194564
49	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.95471911
50	defense response to protozoan (GO:0042832)	2.95114384
51	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.94767965
52	protein localization to endoplasmic reticulum (GO:0070972)	2.94116387
53	translation (GO:0006412)	2.92045074
54	translational initiation (GO:0006413)	2.89767596
55	positive regulation of interleukin-17 production (GO:0032740)	2.89700405
56	rRNA methylation (GO:0031167)	2.89494194
57	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.88660789
58	cellular component biogenesis (GO:0044085)	2.88271847
59	regulation of immunoglobulin secretion (GO:0051023)	2.87085895
60	organelle disassembly (GO:1903008)	2.86471831
61	kynurenine metabolic process (GO:0070189)	2.86222469
62	protein neddylation (GO:0045116)	2.81445256
63	intracellular protein transmembrane import (GO:0044743)	2.79198788
64	regulation of regulatory T cell differentiation (GO:0045589)	2.78928538
65	positive regulation of muscle cell apoptotic process (GO:0010661)	2.77749874
66	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.77338671
67	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.75696253
68	ribonucleoprotein complex biogenesis (GO:0022613)	2.74367738
69	aggressive behavior (GO:0002118)	2.73836151
70	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.73761629
71	proline metabolic process (GO:0006560)	2.72621155
72	positive regulation of protein homodimerization activity (GO:0090073)	2.72252043
73	segment specification (GO:0007379)	2.68982513
74	cellular ketone body metabolic process (GO:0046950)	2.68790423
75	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.68567156
76	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.68567156
77	quinone biosynthetic process (GO:1901663)	2.67772499
78	axoneme assembly (GO:0035082)	2.67407939
79	regulation of interleukin-17 production (GO:0032660)	2.66227355
80	pyrimidine nucleotide catabolic process (GO:0006244)	2.65793182
81	rRNA metabolic process (GO:0016072)	2.65287865
82	purine nucleobase biosynthetic process (GO:0009113)	2.64996008
83	rRNA processing (GO:0006364)	2.64118996
84	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.63441877
85	auditory receptor cell stereocilium organization (GO:0060088)	2.63029988
86	behavioral response to nicotine (GO:0035095)	2.62958275
87	RNA phosphodiester bond hydrolysis (GO:0090501)	2.60951261
88	mitochondrial genome maintenance (GO:0000002)	2.60264906
89	negative regulation of interleukin-17 production (GO:0032700)	2.58608198
90	ribonucleoprotein complex disassembly (GO:0032988)	2.58167866
91	vitamin biosynthetic process (GO:0009110)	2.54579222
92	ncRNA 3-end processing (GO:0043628)	2.54081487
93	fucose catabolic process (GO:0019317)	2.53158457
94	L-fucose metabolic process (GO:0042354)	2.53158457
95	L-fucose catabolic process (GO:0042355)	2.53158457
96	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.52915296
97	IMP biosynthetic process (GO:0006188)	2.52800383
98	peptidyl-histidine modification (GO:0018202)	2.51427602
99	DNA double-strand break processing (GO:0000729)	2.51234535
100	DNA catabolic process, exonucleolytic (GO:0000738)	2.50917701

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.01416532
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.84538572
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.74015853
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.52927694
5	VDR_22108803_ChIP-Seq_LS180_Human	3.32854466
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.28852163
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.25115136
8	ZNF274_21170338_ChIP-Seq_K562_Hela	3.08542379
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.06950922
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.55494098
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.50113341
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.46387450
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.38624667
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.36744078
15	EZH2_22144423_ChIP-Seq_EOC_Human	2.32738040
16	ELK1_19687146_ChIP-ChIP_HELA_Human	2.16202102
17	EWS_26573619_Chip-Seq_HEK293_Human	2.06700215
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.02032985
19	FUS_26573619_Chip-Seq_HEK293_Human	1.98148981
20	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.96795588
21	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.84710984
22	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.81087239
23	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.77180701
24	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.76878433
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.76153572
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.74411773
27	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.70294088
28	IGF1R_20145208_ChIP-Seq_DFB_Human	1.59312396
29	TTF2_22483619_ChIP-Seq_HELA_Human	1.58706546
30	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.56812256
31	MYC_18940864_ChIP-ChIP_HL60_Human	1.56119787
32	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.54593323
33	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.52851431
34	P300_19829295_ChIP-Seq_ESCs_Human	1.50456652
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.48394306
36	TAF15_26573619_Chip-Seq_HEK293_Human	1.47952959
37	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.46047825
38	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.41779549
39	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.41432328
40	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.40738228
41	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.39268710
42	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.38157978
43	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.38157978
44	ER_23166858_ChIP-Seq_MCF-7_Human	1.37768218
45	NANOG_19829295_ChIP-Seq_ESCs_Human	1.35833386
46	SOX2_19829295_ChIP-Seq_ESCs_Human	1.35833386
47	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.32381573
48	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.31328039
49	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.28730092
50	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.27889016
51	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.27312887
52	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.25396193
53	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.19558064
54	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17313851
55	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.16050755
56	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.15494815
57	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.14872177
58	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14782051
59	IRF1_19129219_ChIP-ChIP_H3396_Human	1.11370652
60	GBX2_23144817_ChIP-Seq_PC3_Human	1.10334434
61	AR_20517297_ChIP-Seq_VCAP_Human	1.06123787
62	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.05644885
63	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.05546191
64	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.04235448
65	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.03496338
66	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.03337361
67	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.03213242
68	DCP1A_22483619_ChIP-Seq_HELA_Human	1.03131811
69	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.01788075
70	MYC_19829295_ChIP-Seq_ESCs_Human	1.01714716
71	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.01185292
72	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.00882733
73	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.99098174
74	GATA3_26560356_Chip-Seq_TH2_Human	0.97814599
75	RNF2_27304074_Chip-Seq_NSC_Mouse	0.97155935
76	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.96890551
77	RBPJ_21746931_ChIP-Seq_IB4_Human	0.96860099
78	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.96829607
79	NANOG_20526341_ChIP-Seq_ESCs_Human	0.94302700
80	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.93864519
81	BCAT_22108803_ChIP-Seq_LS180_Human	0.93496260
82	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.92628971
83	ERG_20517297_ChIP-Seq_VCAP_Human	0.92433695
84	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.90452976
85	GABP_19822575_ChIP-Seq_HepG2_Human	0.89677064
86	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.89126602
87	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.89109947
88	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.89093943
89	NCOR_22424771_ChIP-Seq_293T_Human	0.88822656
90	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.88018058
91	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.87818093
92	HOXB7_26014856_ChIP-Seq_BT474_Human	0.87766249
93	TAF2_19829295_ChIP-Seq_ESCs_Human	0.87527277
94	P53_22387025_ChIP-Seq_ESCs_Mouse	0.87149116
95	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.86716476
96	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.86395757
97	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.85991748
98	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.85507208
99	GATA1_22025678_ChIP-Seq_K562_Human	0.84937251
100	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.84679130

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.67159284
2	MP0005645_abnormal_hypothalamus_physiol	3.11070541
3	MP0003806_abnormal_nucleotide_metabolis	2.98365913
4	MP0004145_abnormal_muscle_electrophysio	2.94920769
5	MP0004147_increased_porphyrin_level	2.87704089
6	MP0001873_stomach_inflammation	2.79847092
7	MP0008877_abnormal_DNA_methylation	2.61282445
8	MP0001835_abnormal_antigen_presentation	2.53252213
9	MP0002837_dystrophic_cardiac_calcinosis	2.46119500
10	MP0006072_abnormal_retinal_apoptosis	2.21571983
11	MP0003787_abnormal_imprinting	2.19310326
12	MP0002102_abnormal_ear_morphology	2.15026684
13	MP0005174_abnormal_tail_pigmentation	2.06084759
14	MP0003880_abnormal_central_pattern	1.94192005
15	MP0009333_abnormal_splenocyte_physiolog	1.91488523
16	MP0002160_abnormal_reproductive_system	1.88474796
17	MP0000569_abnormal_digit_pigmentation	1.86892142
18	MP0005646_abnormal_pituitary_gland	1.81409759
19	MP0003195_calcinosis	1.81296476
20	MP0002163_abnormal_gland_morphology	1.78822032
21	MP0005084_abnormal_gallbladder_morpholo	1.74986064
22	MP0003718_maternal_effect	1.74443651
23	MP0002876_abnormal_thyroid_physiology	1.71179797
24	MP0008872_abnormal_physiological_respon	1.70503720
25	MP0008995_early_reproductive_senescence	1.65575551
26	MP0005551_abnormal_eye_electrophysiolog	1.63815776
27	MP0006276_abnormal_autonomic_nervous	1.57476967
28	MP0008875_abnormal_xenobiotic_pharmacok	1.54342404
29	MP0001764_abnormal_homeostasis	1.53671838
30	MP0005075_abnormal_melanosome_morpholog	1.50113599
31	MP0005671_abnormal_response_to	1.43213001
32	MP0001293_anophthalmia	1.41142432
33	MP0001905_abnormal_dopamine_level	1.38311731
34	MP0003646_muscle_fatigue	1.37935991
35	MP0002277_abnormal_respiratory_mucosa	1.36473859
36	MP0002234_abnormal_pharynx_morphology	1.35358896
37	MP0009379_abnormal_foot_pigmentation	1.33550928
38	MP0002138_abnormal_hepatobiliary_system	1.31415397
39	MP0005253_abnormal_eye_physiology	1.30211932
40	MP0001188_hyperpigmentation	1.29867334
41	MP0001968_abnormal_touch/_nociception	1.29850267
42	MP0002938_white_spotting	1.29464930
43	MP0008058_abnormal_DNA_repair	1.28352484
44	MP0002736_abnormal_nociception_after	1.28237202
45	MP0003315_abnormal_perineum_morphology	1.27996503
46	MP0002148_abnormal_hypersensitivity_rea	1.24518372
47	MP0004782_abnormal_surfactant_physiolog	1.24381335
48	MP0005389_reproductive_system_phenotype	1.23497904
49	MP0002272_abnormal_nervous_system	1.20434129
50	MP0000681_abnormal_thyroid_gland	1.18574465
51	MP0004885_abnormal_endolymph	1.18044788
52	MP0003283_abnormal_digestive_organ	1.12116476
53	MP0009046_muscle_twitch	1.06868132
54	MP0004142_abnormal_muscle_tone	1.06040132
55	MP0001501_abnormal_sleep_pattern	1.05233632
56	MP0002405_respiratory_system_inflammati	1.05099112
57	MP0005379_endocrine/exocrine_gland_phen	1.02735766
58	MP0006036_abnormal_mitochondrial_physio	1.00277926
59	MP0005636_abnormal_mineral_homeostasis	0.98988254
60	MP0002733_abnormal_thermal_nociception	0.98046664
61	MP0005387_immune_system_phenotype	0.97888690
62	MP0001790_abnormal_immune_system	0.97888690
63	MP0009250_abnormal_appendicular_skeleto	0.96407347
64	MP0002095_abnormal_skin_pigmentation	0.95300252
65	MP0009745_abnormal_behavioral_response	0.94885811
66	MP0001986_abnormal_taste_sensitivity	0.94724628
67	MP0002210_abnormal_sex_determination	0.93467515
68	MP0002638_abnormal_pupillary_reflex	0.93245838
69	MP0001348_abnormal_lacrimal_gland	0.92238394
70	MP0000631_abnormal_neuroendocrine_gland	0.91559846
71	MP0001800_abnormal_humoral_immune	0.90214936
72	MP0003121_genomic_imprinting	0.89876079
73	MP0001970_abnormal_pain_threshold	0.88778777
74	MP0003011_delayed_dark_adaptation	0.88017214
75	MP0002735_abnormal_chemical_nociception	0.86446369
76	MP0003186_abnormal_redox_activity	0.86400674
77	MP0009765_abnormal_xenobiotic_induced	0.82539967
78	MP0003878_abnormal_ear_physiology	0.81311104
79	MP0005377_hearing/vestibular/ear_phenot	0.81311104
80	MP0004133_heterotaxia	0.81304781
81	MP0008007_abnormal_cellular_replicative	0.79696572
82	MP0003567_abnormal_fetal_cardiomyocyte	0.79683011
83	MP0001502_abnormal_circadian_rhythm	0.79473296
84	MP0005670_abnormal_white_adipose	0.78711735
85	MP0002572_abnormal_emotion/affect_behav	0.78005102
86	MP0002693_abnormal_pancreas_physiology	0.76660449
87	MP0005410_abnormal_fertilization	0.75700660
88	MP0002229_neurodegeneration	0.75032538
89	MP0008789_abnormal_olfactory_epithelium	0.74734134
90	MP0001929_abnormal_gametogenesis	0.72883739
91	MP0002557_abnormal_social/conspecific_i	0.71854570
92	MP0001119_abnormal_female_reproductive	0.71674031
93	MP0000372_irregular_coat_pigmentation	0.70357183
94	MP0003937_abnormal_limbs/digits/tail_de	0.69655080
95	MP0003763_abnormal_thymus_physiology	0.69590988
96	MP0001486_abnormal_startle_reflex	0.68312860
97	MP0005000_abnormal_immune_tolerance	0.68265650
98	MP0004215_abnormal_myocardial_fiber	0.68029256
99	MP0003786_premature_aging	0.66977067
100	MP0000653_abnormal_sex_gland	0.66504286

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.67855478
2	Abnormal rod and cone electroretinograms (HP:0008323)	4.10080848
3	Increased hepatocellular lipid droplets (HP:0006565)	3.88567343
4	Methylmalonic acidemia (HP:0002912)	3.64008281
5	Acute necrotizing encephalopathy (HP:0006965)	3.45073781
6	Mitochondrial inheritance (HP:0001427)	3.44452416
7	Lipid accumulation in hepatocytes (HP:0006561)	3.43493405
8	Congenital stationary night blindness (HP:0007642)	3.38281963
9	Decreased central vision (HP:0007663)	3.28382311
10	Increased CSF lactate (HP:0002490)	3.26377948
11	Molar tooth sign on MRI (HP:0002419)	3.22554178
12	Abnormality of midbrain morphology (HP:0002418)	3.22554178
13	Increased intramyocellular lipid droplets (HP:0012240)	3.13106731
14	Pancreatic fibrosis (HP:0100732)	3.09999120
15	Renal Fanconi syndrome (HP:0001994)	3.05232394
16	Pancreatic cysts (HP:0001737)	3.03880513
17	Constricted visual fields (HP:0001133)	3.03659472
18	Acute encephalopathy (HP:0006846)	3.00552321
19	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.94627994
20	Renal cortical cysts (HP:0000803)	2.91752393
21	Progressive macrocephaly (HP:0004481)	2.90793767
22	3-Methylglutaconic aciduria (HP:0003535)	2.89792441
23	Optic disc pallor (HP:0000543)	2.88885618
24	Nephronophthisis (HP:0000090)	2.88850189
25	Abnormal mitochondria in muscle tissue (HP:0008316)	2.84470212
26	Hepatocellular necrosis (HP:0001404)	2.78970776
27	Methylmalonic aciduria (HP:0012120)	2.73182372
28	Respiratory difficulties (HP:0002880)	2.68102272
29	Attenuation of retinal blood vessels (HP:0007843)	2.64965758
30	Abolished electroretinogram (ERG) (HP:0000550)	2.61546825
31	Hepatic necrosis (HP:0002605)	2.61085792
32	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.59596043
33	Hyperglycinuria (HP:0003108)	2.58814397
34	True hermaphroditism (HP:0010459)	2.55918568
35	Exertional dyspnea (HP:0002875)	2.52645881
36	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.50071716
37	Increased muscle lipid content (HP:0009058)	2.46563555
38	Type I transferrin isoform profile (HP:0003642)	2.45366581
39	Abnormality of methionine metabolism (HP:0010901)	2.42777560
40	Glycosuria (HP:0003076)	2.42121344
41	Abnormality of urine glucose concentration (HP:0011016)	2.42121344
42	Hyperglycinemia (HP:0002154)	2.40644888
43	Increased serum lactate (HP:0002151)	2.38235807
44	Macrocytic anemia (HP:0001972)	2.36746536
45	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.36686390
46	Absent/shortened dynein arms (HP:0200106)	2.36686390
47	Abnormality of the pons (HP:0007361)	2.35794661
48	Abnormality of cells of the erythroid lineage (HP:0012130)	2.34758469
49	Cerebral edema (HP:0002181)	2.34226903
50	Abnormality of the renal cortex (HP:0011035)	2.31386916
51	Abnormality of glycine metabolism (HP:0010895)	2.30164431
52	Abnormality of serine family amino acid metabolism (HP:0010894)	2.30164431
53	Reticulocytopenia (HP:0001896)	2.29612606
54	Genetic anticipation (HP:0003743)	2.26084206
55	Abnormality of renal resorption (HP:0011038)	2.24391842
56	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.24139721
57	Abnormality of the renal medulla (HP:0100957)	2.20789290
58	Lethargy (HP:0001254)	2.20418091
59	Abnormality of vitamin B metabolism (HP:0004340)	2.17134370
60	Hypoplasia of the pons (HP:0012110)	2.17078769
61	Dyschromatopsia (HP:0007641)	2.17046719
62	Abnormal protein glycosylation (HP:0012346)	2.14852955
63	Abnormal glycosylation (HP:0012345)	2.14852955
64	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.14852955
65	Abnormal protein N-linked glycosylation (HP:0012347)	2.14852955
66	Adrenal hypoplasia (HP:0000835)	2.13951145
67	Hypothermia (HP:0002045)	2.12975684
68	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.10991108
69	Reduced antithrombin III activity (HP:0001976)	2.09385070
70	Abnormality of homocysteine metabolism (HP:0010919)	2.09070326
71	Homocystinuria (HP:0002156)	2.09070326
72	Congenital, generalized hypertrichosis (HP:0004540)	2.09065572
73	Abnormal respiratory motile cilium morphology (HP:0005938)	2.08556389
74	Abnormal respiratory epithelium morphology (HP:0012253)	2.08556389
75	Supernumerary spleens (HP:0009799)	2.08474660
76	Hyperphosphaturia (HP:0003109)	2.08155747
77	Increased corneal curvature (HP:0100692)	2.07940942
78	Keratoconus (HP:0000563)	2.07940942
79	Lactic acidosis (HP:0003128)	2.06056620
80	Abnormal number of erythroid precursors (HP:0012131)	2.03567247
81	Bony spicule pigmentary retinopathy (HP:0007737)	2.02718170
82	Absent thumb (HP:0009777)	2.00972097
83	Type II lissencephaly (HP:0007260)	2.00190172
84	Microvesicular hepatic steatosis (HP:0001414)	1.94837146
85	Gaze-evoked nystagmus (HP:0000640)	1.94258315
86	Abnormality of serum amino acid levels (HP:0003112)	1.93280433
87	Abnormality of macular pigmentation (HP:0008002)	1.91182035
88	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.90915711
89	Dicarboxylic aciduria (HP:0003215)	1.90915711
90	Polydipsia (HP:0001959)	1.87838287
91	Abnormal drinking behavior (HP:0030082)	1.87838287
92	Pendular nystagmus (HP:0012043)	1.86979751
93	Progressive cerebellar ataxia (HP:0002073)	1.85066230
94	Myotonia (HP:0002486)	1.84282288
95	Abnormal ciliary motility (HP:0012262)	1.83462625
96	Volvulus (HP:0002580)	1.83173914
97	Colon cancer (HP:0003003)	1.82293141
98	Abnormal biliary tract physiology (HP:0012439)	1.75281385
99	Bile duct proliferation (HP:0001408)	1.75281385
100	Tubulointerstitial nephritis (HP:0001970)	1.74931631

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK19	2.96124137
2	TXK	2.92550478
3	TLK1	2.83351845
4	GRK1	2.71825926
5	WNK4	2.64171388
6	ZAK	2.63822939
7	ADRBK2	2.57520492
8	CAMKK2	2.44412475
9	FRK	2.38959181
10	MAP4K2	2.34741779
11	EIF2AK3	2.33203958
12	TSSK6	2.24696135
13	BCKDK	2.14718263
14	PBK	2.09928754
15	TRIM28	1.93667183
16	OXSR1	1.86631356
17	TRPM7	1.85740818
18	VRK2	1.77283845
19	TIE1	1.72802126
20	VRK1	1.63777989
21	MKNK1	1.63585866
22	NUAK1	1.49874848
23	KIT	1.46618311
24	PASK	1.42113990
25	BMPR1B	1.38287203
26	STK39	1.35539121
27	TEC	1.33072127
28	BRSK2	1.30428615
29	PINK1	1.29219547
30	ITK	1.27401983
31	MST4	1.24563683
32	PLK3	1.16550235
33	TNK2	1.06461081
34	ACVR1B	1.03844487
35	MKNK2	1.00441917
36	CAMKK1	0.99986114
37	IKBKB	0.97297273
38	DYRK2	0.96654192
39	EIF2AK1	0.94483855
40	SYK	0.93729718
41	NME2	0.93163302
42	CDK3	0.92456710
43	INSRR	0.91355990
44	NME1	0.89050380
45	PRKCE	0.88800604
46	PRKCG	0.88762196
47	WNK1	0.87909636
48	CSF1R	0.86029989
49	TNIK	0.85875121
50	WNK3	0.84662246
51	MAP2K6	0.83509870
52	PHKG1	0.82921322
53	PHKG2	0.82921322
54	GRK6	0.80718122
55	PLK4	0.79501943
56	CSNK1G2	0.77447162
57	EIF2AK2	0.76912892
58	PAK3	0.76717992
59	IRAK1	0.75259015
60	CSNK1G1	0.75218461
61	ADRBK1	0.73636660
62	MATK	0.72902979
63	FES	0.72418321
64	TAOK3	0.70774102
65	CSNK1G3	0.70225171
66	NEK1	0.69868057
67	TGFBR1	0.63579588
68	ALK	0.60882879
69	CSNK2A2	0.57470079
70	RPS6KA5	0.56345144
71	PDK2	0.56130232
72	IGF1R	0.55890815
73	PLK1	0.55558114
74	MAP4K1	0.54769902
75	BMPR2	0.54077257
76	ILK	0.53914347
77	PIK3CG	0.53668948
78	PRKCH	0.53251346
79	PRKCQ	0.52384189
80	CDC7	0.50764961
81	BTK	0.50387002
82	SCYL2	0.50066996
83	CSNK1E	0.48226637
84	STK4	0.46843212
85	SRPK1	0.46812905
86	CSNK2A1	0.46549740
87	ATR	0.44564092
88	OBSCN	0.44474734
89	LCK	0.43840785
90	PRKCD	0.43149590
91	TAF1	0.42664236
92	BCR	0.42482478
93	PRKCA	0.41853147
94	CAMK1	0.40008730
95	PRKACA	0.39208773
96	ATM	0.38563311
97	RPS6KA4	0.36425176
98	PLK2	0.35147100
99	CAMK2A	0.34807540
100	CSNK1A1	0.33406169

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.47087424
2	Allograft rejection_Homo sapiens_hsa05330	3.15304371
3	Proteasome_Homo sapiens_hsa03050	3.04396587
4	Asthma_Homo sapiens_hsa05310	2.84948748
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.76724530
6	Type I diabetes mellitus_Homo sapiens_hsa04940	2.68840432
7	RNA polymerase_Homo sapiens_hsa03020	2.48127519
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.39967113
9	Protein export_Homo sapiens_hsa03060	2.37268664
10	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.29815681
11	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.29491822
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.25355519
13	One carbon pool by folate_Homo sapiens_hsa00670	2.19452865
14	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.17471410
15	Parkinsons disease_Homo sapiens_hsa05012	2.15578364
16	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.96918432
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.95131346
18	Phototransduction_Homo sapiens_hsa04744	1.89483394
19	RNA degradation_Homo sapiens_hsa03018	1.77328092
20	Graft-versus-host disease_Homo sapiens_hsa05332	1.76783554
21	Homologous recombination_Homo sapiens_hsa03440	1.68521109
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.63750884
23	Huntingtons disease_Homo sapiens_hsa05016	1.46990005
24	Propanoate metabolism_Homo sapiens_hsa00640	1.46934414
25	Basal transcription factors_Homo sapiens_hsa03022	1.41132759
26	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.40842459
27	Alzheimers disease_Homo sapiens_hsa05010	1.39709444
28	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.35753008
29	Cardiac muscle contraction_Homo sapiens_hsa04260	1.32112153
30	Butanoate metabolism_Homo sapiens_hsa00650	1.32077092
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.27987643
32	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.27639194
33	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.25779566
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.23325739
35	RNA transport_Homo sapiens_hsa03013	1.22969209
36	Selenocompound metabolism_Homo sapiens_hsa00450	1.22470994
37	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.22469451
38	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.21650009
39	Purine metabolism_Homo sapiens_hsa00230	1.20679842
40	Fanconi anemia pathway_Homo sapiens_hsa03460	1.11401556
41	Ether lipid metabolism_Homo sapiens_hsa00565	1.09317661
42	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.07380829
43	Peroxisome_Homo sapiens_hsa04146	1.05644235
44	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.03248999
45	Mismatch repair_Homo sapiens_hsa03430	0.98141121
46	Rheumatoid arthritis_Homo sapiens_hsa05323	0.97078711
47	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.92820131
48	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.91291398
49	Retinol metabolism_Homo sapiens_hsa00830	0.90084207
50	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.88999874
51	Non-homologous end-joining_Homo sapiens_hsa03450	0.87178976
52	Regulation of autophagy_Homo sapiens_hsa04140	0.85657826
53	Tryptophan metabolism_Homo sapiens_hsa00380	0.83592997
54	Spliceosome_Homo sapiens_hsa03040	0.77457561
55	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.76987889
56	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.76146072
57	Mineral absorption_Homo sapiens_hsa04978	0.74381833
58	Steroid biosynthesis_Homo sapiens_hsa00100	0.73812480
59	African trypanosomiasis_Homo sapiens_hsa05143	0.73241536
60	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.73088905
61	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.72159175
62	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.70921662
63	Metabolic pathways_Homo sapiens_hsa01100	0.68383007
64	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.68042519
65	Nucleotide excision repair_Homo sapiens_hsa03420	0.67196477
66	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.66340589
67	Fat digestion and absorption_Homo sapiens_hsa04975	0.65251064
68	Nitrogen metabolism_Homo sapiens_hsa00910	0.64630168
69	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.61839063
70	Primary immunodeficiency_Homo sapiens_hsa05340	0.60708550
71	Nicotine addiction_Homo sapiens_hsa05033	0.57816658
72	Caffeine metabolism_Homo sapiens_hsa00232	0.56323076
73	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.56224336
74	Olfactory transduction_Homo sapiens_hsa04740	0.55887104
75	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.54213743
76	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.53220601
77	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.52615912
78	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.51888668
79	Chemical carcinogenesis_Homo sapiens_hsa05204	0.50720867
80	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.50268911
81	Base excision repair_Homo sapiens_hsa03410	0.49477584
82	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.46911824
83	Antigen processing and presentation_Homo sapiens_hsa04612	0.46858130
84	Folate biosynthesis_Homo sapiens_hsa00790	0.45858614
85	Arginine and proline metabolism_Homo sapiens_hsa00330	0.44815568
86	DNA replication_Homo sapiens_hsa03030	0.43892889
87	beta-Alanine metabolism_Homo sapiens_hsa00410	0.40822487
88	Sulfur metabolism_Homo sapiens_hsa00920	0.38471399
89	Taste transduction_Homo sapiens_hsa04742	0.37991396
90	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.36905533
91	Legionellosis_Homo sapiens_hsa05134	0.36480678
92	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.35543155
93	Collecting duct acid secretion_Homo sapiens_hsa04966	0.35259393
94	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.34579303
95	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.33430549
96	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.32962312
97	Serotonergic synapse_Homo sapiens_hsa04726	0.31958924
98	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.31430797
99	Sulfur relay system_Homo sapiens_hsa04122	0.27595194
100	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.24176040

RPL5P27

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »