ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	8.74299208
2	translational termination (GO:0006415)	8.38787665
3	ribosomal small subunit assembly (GO:0000028)	7.60834812
4	translational elongation (GO:0006414)	7.17499525
5	ribosomal small subunit biogenesis (GO:0042274)	7.14637327
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.96633461
7	cotranslational protein targeting to membrane (GO:0006613)	6.85769024
8	protein targeting to ER (GO:0045047)	6.78426313
9	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.46558652
10	cellular protein complex disassembly (GO:0043624)	6.37710909
11	viral life cycle (GO:0019058)	6.36942646
12	protein localization to endoplasmic reticulum (GO:0070972)	6.31292948
13	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.98034145
14	maturation of SSU-rRNA (GO:0030490)	5.88819729
15	ribosomal large subunit biogenesis (GO:0042273)	5.45413931
16	protein complex disassembly (GO:0043241)	5.35238137
17	translational initiation (GO:0006413)	5.30508702
18	ATP synthesis coupled proton transport (GO:0015986)	5.29806561
19	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.29806561
20	macromolecular complex disassembly (GO:0032984)	5.02459056
21	sequestering of actin monomers (GO:0042989)	4.97708706
22	protein complex biogenesis (GO:0070271)	4.68218745
23	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.49793505
24	NADH dehydrogenase complex assembly (GO:0010257)	4.49793505
25	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.49793505
26	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.48072852
27	protein targeting to membrane (GO:0006612)	4.46404896
28	mitochondrial respiratory chain complex assembly (GO:0033108)	4.39915226
29	ribonucleoprotein complex biogenesis (GO:0022613)	4.30907820
30	behavioral response to nicotine (GO:0035095)	4.28322955
31	translation (GO:0006412)	4.27274244
32	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.22008373
33	respiratory chain complex IV assembly (GO:0008535)	4.16843264
34	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.13621583
35	cellular component biogenesis (GO:0044085)	4.10350513
36	protein neddylation (GO:0045116)	4.03844138
37	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.00244500
38	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.00244500
39	mRNA catabolic process (GO:0006402)	3.88182100
40	nucleotide salvage (GO:0043173)	3.80442542
41	water-soluble vitamin biosynthetic process (GO:0042364)	3.78484301
42	mitochondrial calcium ion transport (GO:0006851)	3.73573667
43	cytochrome complex assembly (GO:0017004)	3.72459476
44	respiratory electron transport chain (GO:0022904)	3.72364020
45	electron transport chain (GO:0022900)	3.70746661
46	regulation of cellular respiration (GO:0043457)	3.50040200
47	RNA catabolic process (GO:0006401)	3.46852920
48	ATP biosynthetic process (GO:0006754)	3.43658735
49	negative regulation of glycogen biosynthetic process (GO:0045719)	3.43128564
50	regulation of energy homeostasis (GO:2000505)	3.37754650
51	tolerance induction (GO:0002507)	3.37118041
52	CTP metabolic process (GO:0046036)	3.36583943
53	CTP biosynthetic process (GO:0006241)	3.36583943
54	chaperone-mediated protein transport (GO:0072321)	3.31297733
55	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	3.28788736
56	UMP biosynthetic process (GO:0006222)	3.28788736
57	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	3.28788736
58	UMP metabolic process (GO:0046049)	3.28788736
59	nucleoside salvage (GO:0043174)	3.28317602
60	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.27175999
61	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	3.27155489
62	DNA deamination (GO:0045006)	3.23896832
63	hydrogen ion transmembrane transport (GO:1902600)	3.17869946
64	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.17224090
65	maturation of 5.8S rRNA (GO:0000460)	3.14998520
66	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	3.13508116
67	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.12330907
68	cysteine metabolic process (GO:0006534)	3.02052618
69	proton transport (GO:0015992)	2.96128905
70	protein-cofactor linkage (GO:0018065)	2.94432232
71	interleukin-6-mediated signaling pathway (GO:0070102)	2.92383921
72	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.92379111
73	ribosome biogenesis (GO:0042254)	2.91909221
74	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.90097031
75	establishment of protein localization to membrane (GO:0090150)	2.89652129
76	hydrogen transport (GO:0006818)	2.87452103
77	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.81202764
78	galactose catabolic process (GO:0019388)	2.80946264
79	protein targeting (GO:0006605)	2.80245150
80	regulation of interleukin-12 biosynthetic process (GO:0045075)	2.79483644
81	negative regulation of cardiac muscle hypertrophy (GO:0010614)	2.77189419
82	nucleoside triphosphate biosynthetic process (GO:0009142)	2.73644544
83	pyrimidine-containing compound salvage (GO:0008655)	2.72554005
84	pyrimidine nucleoside salvage (GO:0043097)	2.72554005
85	negative regulation of glycogen metabolic process (GO:0070874)	2.69408921
86	forebrain morphogenesis (GO:0048853)	2.69347115
87	cell proliferation in forebrain (GO:0021846)	2.68508594
88	protein polyglutamylation (GO:0018095)	2.68503094
89	establishment of protein localization to organelle (GO:0072594)	2.68107652
90	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.67348792
91	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.64750981
92	regulation of activation of Janus kinase activity (GO:0010533)	2.63847370
93	rRNA processing (GO:0006364)	2.63173047
94	purine nucleotide salvage (GO:0032261)	2.61527424
95	rRNA metabolic process (GO:0016072)	2.58582146
96	regulation of hypersensitivity (GO:0002883)	2.58111019
97	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.54425794
98	negative regulation of muscle hypertrophy (GO:0014741)	2.51530903
99	ubiquinone biosynthetic process (GO:0006744)	2.50413383
100	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	2.45524158

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.66188795
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.31234260
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.27647653
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.19823903
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.10614857
6	VDR_22108803_ChIP-Seq_LS180_Human	2.91187315
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.72791126
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.64455184
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.46448099
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.42448435
11	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.38493055
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.26030504
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.21857621
14	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.20616316
15	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.01658938
16	IGF1R_20145208_ChIP-Seq_DFB_Human	1.93209430
17	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.93117654
18	MYC_18940864_ChIP-ChIP_HL60_Human	1.88983181
19	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.85824226
20	VDR_23849224_ChIP-Seq_CD4+_Human	1.82190559
21	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.77114244
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.74811185
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.74100286
24	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.74039123
25	XRN2_22483619_ChIP-Seq_HELA_Human	1.72361277
26	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.69439517
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.65968647
28	EWS_26573619_Chip-Seq_HEK293_Human	1.64656047
29	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.63847955
30	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.59835466
31	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.59315928
32	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.57411852
33	TTF2_22483619_ChIP-Seq_HELA_Human	1.56750809
34	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.55653630
35	ELK1_19687146_ChIP-ChIP_HELA_Human	1.52725529
36	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.49287933
37	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.48801506
38	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.48801506
39	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.48801506
40	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.47691395
41	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.38771147
42	FOXP3_21729870_ChIP-Seq_TREG_Human	1.37486234
43	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.37302781
44	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.36282438
45	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.36034934
46	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.35018509
47	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.34299853
48	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.33559965
49	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.29439362
50	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.28904510
51	FUS_26573619_Chip-Seq_HEK293_Human	1.27868775
52	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.27040678
53	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.26892942
54	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.26046707
55	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.23560963
56	NCOR_22424771_ChIP-Seq_293T_Human	1.23328218
57	IRF1_19129219_ChIP-ChIP_H3396_Human	1.20412010
58	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.20224011
59	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.19037639
60	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.18558186
61	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.16708577
62	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.16541237
63	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.15635618
64	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.15317680
65	RNF2_27304074_Chip-Seq_NSC_Mouse	1.15008503
66	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.14494323
67	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.13884401
68	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.13181685
69	NANOG_20526341_ChIP-Seq_ESCs_Human	1.11002108
70	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.10657681
71	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.10569007
72	REST_21632747_ChIP-Seq_MESCs_Mouse	1.10333398
73	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.10140328
74	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.07700741
75	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.06344389
76	HTT_18923047_ChIP-ChIP_STHdh_Human	1.04199903
77	AR_20517297_ChIP-Seq_VCAP_Human	1.03660815
78	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.03490166
79	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.03442268
80	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.02880672
81	SA1_27219007_Chip-Seq_Bcells_Human	1.02242002
82	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.98697546
83	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.98671672
84	ER_23166858_ChIP-Seq_MCF-7_Human	0.98271126
85	AR_21572438_ChIP-Seq_LNCaP_Human	0.97128404
86	RBPJ_21746931_ChIP-Seq_IB4_Human	0.95360487
87	PHF8_20622853_ChIP-Seq_HELA_Human	0.95074342
88	TAF2_19829295_ChIP-Seq_ESCs_Human	0.94705626
89	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.94099807
90	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.93831246
91	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.93558562
92	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.92862976
93	ERA_21632823_ChIP-Seq_H3396_Human	0.92510847
94	P300_19829295_ChIP-Seq_ESCs_Human	0.92199504
95	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.89349740
96	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.88930224
97	CBP_20019798_ChIP-Seq_JUKART_Human	0.88930224
98	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.88673150
99	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.88363009
100	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.88363009

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002653_abnormal_ependyma_morphology	4.74411930
2	MP0009379_abnormal_foot_pigmentation	4.72280137
3	MP0006292_abnormal_olfactory_placode	4.03648957
4	MP0002837_dystrophic_cardiac_calcinosis	3.79937007
5	MP0002163_abnormal_gland_morphology	3.41369895
6	MP0006054_spinal_hemorrhage	3.15224113
7	MP0004145_abnormal_muscle_electrophysio	2.31878576
8	MP0004885_abnormal_endolymph	2.31454435
9	MP0004142_abnormal_muscle_tone	2.05669805
10	MP0003646_muscle_fatigue	1.99626026
11	MP0008872_abnormal_physiological_respon	1.98653987
12	MP0004147_increased_porphyrin_level	1.98110443
13	MP0003011_delayed_dark_adaptation	1.89298829
14	MP0005379_endocrine/exocrine_gland_phen	1.88410301
15	MP0002102_abnormal_ear_morphology	1.83987889
16	MP0001348_abnormal_lacrimal_gland	1.80953541
17	MP0002938_white_spotting	1.80201632
18	MP0001986_abnormal_taste_sensitivity	1.79698353
19	MP0008875_abnormal_xenobiotic_pharmacok	1.74014277
20	MP0002638_abnormal_pupillary_reflex	1.72991289
21	MP0003195_calcinosis	1.66810056
22	MP0002234_abnormal_pharynx_morphology	1.66598750
23	MP0005377_hearing/vestibular/ear_phenot	1.57551243
24	MP0003878_abnormal_ear_physiology	1.57551243
25	MP0001346_abnormal_lacrimal_gland	1.48228911
26	MP0002160_abnormal_reproductive_system	1.47539914
27	MP0003186_abnormal_redox_activity	1.43734345
28	MP0005623_abnormal_meninges_morphology	1.42357952
29	MP0000049_abnormal_middle_ear	1.35744954
30	MP0001919_abnormal_reproductive_system	1.35662930
31	MP0001968_abnormal_touch/_nociception	1.34249023
32	MP0005389_reproductive_system_phenotype	1.33500117
33	MP0003693_abnormal_embryo_hatching	1.27306006
34	MP0000372_irregular_coat_pigmentation	1.25465059
35	MP0005646_abnormal_pituitary_gland	1.24951847
36	MP0001293_anophthalmia	1.24806490
37	MP0006072_abnormal_retinal_apoptosis	1.24231717
38	MP0002736_abnormal_nociception_after	1.23117851
39	MP0005671_abnormal_response_to	1.22002524
40	MP0004215_abnormal_myocardial_fiber	1.20187670
41	MP0002272_abnormal_nervous_system	1.18079997
42	MP0001764_abnormal_homeostasis	1.17703954
43	MP0006276_abnormal_autonomic_nervous	1.16947445
44	MP0003279_aneurysm	1.16661684
45	MP0008789_abnormal_olfactory_epithelium	1.15966869
46	MP0001905_abnormal_dopamine_level	1.12643585
47	MP0009745_abnormal_behavioral_response	1.12606960
48	MP0008995_early_reproductive_senescence	1.11643759
49	MP0002095_abnormal_skin_pigmentation	1.11484117
50	MP0005084_abnormal_gallbladder_morpholo	1.10694374
51	MP0004130_abnormal_muscle_cell	1.10655250
52	MP0005551_abnormal_eye_electrophysiolog	1.09825585
53	MP0001529_abnormal_vocalization	1.09327746
54	MP0008775_abnormal_heart_ventricle	1.09179188
55	MP0004742_abnormal_vestibular_system	1.08971009
56	MP0003136_yellow_coat_color	1.05188802
57	MP0004084_abnormal_cardiac_muscle	1.04909663
58	MP0002733_abnormal_thermal_nociception	0.98639510
59	MP0001485_abnormal_pinna_reflex	0.98444715
60	MP0009765_abnormal_xenobiotic_induced	0.96971756
61	MP0009250_abnormal_appendicular_skeleto	0.90520230
62	MP0001440_abnormal_grooming_behavior	0.89843808
63	MP0002693_abnormal_pancreas_physiology	0.88710438
64	MP0009785_altered_susceptibility_to	0.88165043
65	MP0001873_stomach_inflammation	0.87303566
66	MP0002822_catalepsy	0.86617561
67	MP0003787_abnormal_imprinting	0.86581193
68	MP0001286_abnormal_eye_development	0.86288267
69	MP0001970_abnormal_pain_threshold	0.86221340
70	MP0005645_abnormal_hypothalamus_physiol	0.86217935
71	MP0005253_abnormal_eye_physiology	0.85266940
72	MP0000566_synostosis	0.84383569
73	MP0002735_abnormal_chemical_nociception	0.83094705
74	MP0003567_abnormal_fetal_cardiomyocyte	0.83088289
75	MP0003786_premature_aging	0.82288355
76	MP0002277_abnormal_respiratory_mucosa	0.81783699
77	MP0000538_abnormal_urinary_bladder	0.80919110
78	MP0000026_abnormal_inner_ear	0.80699801
79	MP0001486_abnormal_startle_reflex	0.76939713
80	MP0006036_abnormal_mitochondrial_physio	0.76725993
81	MP0005503_abnormal_tendon_morphology	0.76678294
82	MP0003880_abnormal_central_pattern	0.73290966
83	MP0003119_abnormal_digestive_system	0.72666161
84	MP0000631_abnormal_neuroendocrine_gland	0.72630505
85	MP0004133_heterotaxia	0.72502847
86	MP0002752_abnormal_somatic_nervous	0.72278997
87	MP0001944_abnormal_pancreas_morphology	0.72182063
88	MP0005332_abnormal_amino_acid	0.71589000
89	MP0005360_urolithiasis	0.71388283
90	MP0005195_abnormal_posterior_eye	0.70669257
91	MP0005075_abnormal_melanosome_morpholog	0.70661575
92	MP0001984_abnormal_olfaction	0.69968031
93	MP0003283_abnormal_digestive_organ	0.67181532
94	MP0003938_abnormal_ear_development	0.65344623
95	MP0009046_muscle_twitch	0.64181322
96	MP0005448_abnormal_energy_balance	0.63355910
97	MP0002184_abnormal_innervation	0.63255110
98	MP0002876_abnormal_thyroid_physiology	0.62284689
99	MP0001800_abnormal_humoral_immune	0.59786451
100	MP0005636_abnormal_mineral_homeostasis	0.57604577

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal number of erythroid precursors (HP:0012131)	5.16138291
2	Abnormality of cells of the erythroid lineage (HP:0012130)	5.16046253
3	Acute necrotizing encephalopathy (HP:0006965)	5.08831288
4	Acute encephalopathy (HP:0006846)	4.38819085
5	Mitochondrial inheritance (HP:0001427)	4.35840355
6	Abnormal mitochondria in muscle tissue (HP:0008316)	4.35682314
7	Progressive macrocephaly (HP:0004481)	4.23022475
8	Increased hepatocellular lipid droplets (HP:0006565)	4.18736909
9	Chronic hepatic failure (HP:0100626)	3.98425209
10	Lipid accumulation in hepatocytes (HP:0006561)	3.76096891
11	Increased CSF lactate (HP:0002490)	3.69507385
12	Renal Fanconi syndrome (HP:0001994)	3.65591487
13	Hepatocellular necrosis (HP:0001404)	3.59523355
14	Macrocytic anemia (HP:0001972)	3.57842889
15	Reticulocytopenia (HP:0001896)	3.47269591
16	Congenital stationary night blindness (HP:0007642)	3.32299621
17	Pallor (HP:0000980)	3.26523443
18	Pancreatic cysts (HP:0001737)	3.25781734
19	Hepatic necrosis (HP:0002605)	3.21581150
20	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.12514864
21	Absent/shortened dynein arms (HP:0200106)	3.12514864
22	Cerebral edema (HP:0002181)	3.07407597
23	Increased intramyocellular lipid droplets (HP:0012240)	3.03917676
24	Abnormal hemoglobin (HP:0011902)	3.00141854
25	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.95563507
26	Exertional dyspnea (HP:0002875)	2.91848246
27	Hypoplasia of the pons (HP:0012110)	2.85470843
28	Concave nail (HP:0001598)	2.84919669
29	Optic disc pallor (HP:0000543)	2.79869285
30	Pancreatic fibrosis (HP:0100732)	2.70237487
31	Abnormality of the pons (HP:0007361)	2.66647884
32	True hermaphroditism (HP:0010459)	2.58012431
33	Increased muscle lipid content (HP:0009058)	2.51068626
34	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.47027079
35	Abnormality of alanine metabolism (HP:0010916)	2.47027079
36	Hyperalaninemia (HP:0003348)	2.47027079
37	Abnormal respiratory motile cilium morphology (HP:0005938)	2.42429975
38	Abnormal respiratory epithelium morphology (HP:0012253)	2.42429975
39	Abnormal number of incisors (HP:0011064)	2.39122188
40	Abnormality of renal resorption (HP:0011038)	2.34686181
41	Abnormality of urine glucose concentration (HP:0011016)	2.34473371
42	Glycosuria (HP:0003076)	2.34473371
43	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.34185826
44	Hyperglycinemia (HP:0002154)	2.32621510
45	Respiratory failure (HP:0002878)	2.30894008
46	Hyperphosphaturia (HP:0003109)	2.29459746
47	Mutism (HP:0002300)	2.29128139
48	Abnormality of the renal cortex (HP:0011035)	2.28710293
49	Abnormal rod and cone electroretinograms (HP:0008323)	2.28347791
50	Exercise intolerance (HP:0003546)	2.27219976
51	Leukodystrophy (HP:0002415)	2.27035024
52	Lactic acidosis (HP:0003128)	2.23504928
53	Increased serum lactate (HP:0002151)	2.23368054
54	Abnormal ciliary motility (HP:0012262)	2.20531712
55	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.19474107
56	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.19474107
57	Progressive inability to walk (HP:0002505)	2.16764220
58	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.16671323
59	Congenital, generalized hypertrichosis (HP:0004540)	2.16648372
60	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.16111682
61	Dyskinesia (HP:0100660)	2.12162825
62	Absent thumb (HP:0009777)	2.11351159
63	Abnormality of midbrain morphology (HP:0002418)	2.05239004
64	Molar tooth sign on MRI (HP:0002419)	2.05239004
65	Pendular nystagmus (HP:0012043)	2.03803690
66	Oral leukoplakia (HP:0002745)	2.02993020
67	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.02580552
68	Asplenia (HP:0001746)	2.01080095
69	Anencephaly (HP:0002323)	2.00559565
70	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.99227730
71	Decreased central vision (HP:0007663)	1.98894376
72	Abnormal respiratory motile cilium physiology (HP:0012261)	1.98631681
73	Stomatitis (HP:0010280)	1.96177603
74	Sclerocornea (HP:0000647)	1.93902650
75	Poor suck (HP:0002033)	1.93332598
76	3-Methylglutaconic aciduria (HP:0003535)	1.92085632
77	Anophthalmia (HP:0000528)	1.90128410
78	Nephronophthisis (HP:0000090)	1.87315929
79	Methylmalonic acidemia (HP:0002912)	1.87079158
80	Polyuria (HP:0000103)	1.86769698
81	Respiratory difficulties (HP:0002880)	1.85805518
82	Lethargy (HP:0001254)	1.85689313
83	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.85668088
84	Inability to walk (HP:0002540)	1.84763970
85	Cystic liver disease (HP:0006706)	1.84762621
86	Medial flaring of the eyebrow (HP:0010747)	1.82992063
87	Aplastic anemia (HP:0001915)	1.82866880
88	Abnormality of the renal medulla (HP:0100957)	1.82526787
89	Parakeratosis (HP:0001036)	1.81566930
90	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.81562911
91	Renal cortical cysts (HP:0000803)	1.77897982
92	Hypoplasia of the uterus (HP:0000013)	1.75737452
93	Abnormal drinking behavior (HP:0030082)	1.74727778
94	Polydipsia (HP:0001959)	1.74727778
95	Rhinitis (HP:0012384)	1.71523111
96	Pancytopenia (HP:0001876)	1.69875922
97	Restlessness (HP:0000711)	1.67900516
98	Abnormal urine phosphate concentration (HP:0012599)	1.67551214
99	Postaxial foot polydactyly (HP:0001830)	1.67520956
100	Aplasia/hypoplasia of the uterus (HP:0008684)	1.67390589

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PASK	7.79268342
2	TXK	3.77070581
3	CAMKK1	3.63395285
4	ADRBK2	2.98106323
5	MAP3K13	2.88834855
6	TLK1	2.55285788
7	MAP4K1	2.34233010
8	VRK2	2.31924571
9	GRK1	2.27520435
10	CAMKK2	2.21881235
11	LIMK1	1.95196050
12	ZAK	1.68168080
13	LRRK2	1.64285262
14	WNK3	1.52772334
15	WNK4	1.52178265
16	DYRK2	1.45960310
17	PINK1	1.43960644
18	MAP4K2	1.36064409
19	NME1	1.22002815
20	CASK	1.18318927
21	FRK	1.17874487
22	NUAK1	1.16511060
23	BCKDK	1.14317178
24	INSRR	1.13251501
25	PRKCQ	1.13216340
26	SYK	1.08645232
27	BRSK2	1.06628491
28	BMPR1B	1.05913184
29	TNIK	1.01256796
30	ITK	1.01048314
31	RPS6KA5	1.00206995
32	PDK2	1.00186465
33	VRK1	0.99125190
34	IKBKB	0.94772540
35	SIK2	0.94587452
36	RIPK4	0.93051248
37	ACVR1B	0.89668391
38	KDR	0.89434552
39	BUB1	0.89270611
40	JAK3	0.86422023
41	TEC	0.79576875
42	GRK6	0.78701004
43	BTK	0.77682300
44	ADRBK1	0.77251845
45	NLK	0.76217127
46	PRKCG	0.75858657
47	MAPK13	0.73816708
48	MAP2K7	0.73534884
49	GRK7	0.72412936
50	PLK4	0.71012856
51	CSNK1G1	0.70794971
52	OBSCN	0.66827671
53	NME2	0.66419167
54	TIE1	0.65949882
55	CSNK2A2	0.65794114
56	LCK	0.63859712
57	MARK1	0.62805693
58	TAOK3	0.60815541
59	MAP3K4	0.58518845
60	CSNK1G2	0.58390564
61	NEK2	0.57613454
62	LYN	0.53351074
63	MUSK	0.53322231
64	IKBKE	0.53064285
65	TYRO3	0.52994445
66	CSNK2A1	0.50929860
67	CLK1	0.50187674
68	CSNK1G3	0.48725469
69	CSNK1A1	0.47587622
70	TGFBR1	0.46935439
71	ABL2	0.46881253
72	PHKG1	0.46794426
73	PHKG2	0.46794426
74	WEE1	0.46500298
75	PRKACA	0.45359658
76	SGK223	0.45162419
77	SGK494	0.45162419
78	STK4	0.44998290
79	MAP3K14	0.44656146
80	CAMK1	0.44477461
81	MAP2K2	0.43457186
82	PIM1	0.43140294
83	MAPKAPK3	0.40846772
84	MAP3K9	0.39842597
85	STK16	0.39507134
86	TESK2	0.39386117
87	STK11	0.39220546
88	PAK3	0.37519783
89	PRKCA	0.36874680
90	MAPK15	0.36798293
91	PLK1	0.34700805
92	NTRK2	0.34072048
93	ATR	0.32703851
94	CHEK2	0.32552842
95	PAK6	0.32011007
96	BLK	0.31188816
97	CAMK2A	0.30988033
98	MAP2K6	0.30141961
99	FES	0.29864662
100	MINK1	0.29620142

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.17118199
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.22209429
3	Parkinsons disease_Homo sapiens_hsa05012	3.46360011
4	Sulfur relay system_Homo sapiens_hsa04122	2.92302416
5	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.54962089
6	Alzheimers disease_Homo sapiens_hsa05010	2.31759848
7	Huntingtons disease_Homo sapiens_hsa05016	2.30883385
8	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.30144477
9	Cardiac muscle contraction_Homo sapiens_hsa04260	2.21174196
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.03392637
11	Proteasome_Homo sapiens_hsa03050	2.03109613
12	RNA polymerase_Homo sapiens_hsa03020	1.90520508
13	Homologous recombination_Homo sapiens_hsa03440	1.65696291
14	Primary immunodeficiency_Homo sapiens_hsa05340	1.60382840
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.53758118
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.49304720
17	Pyrimidine metabolism_Homo sapiens_hsa00240	1.45382242
18	Sulfur metabolism_Homo sapiens_hsa00920	1.40980594
19	Nicotine addiction_Homo sapiens_hsa05033	1.36608768
20	Asthma_Homo sapiens_hsa05310	1.35210534
21	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.34881345
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.34527715
23	RNA degradation_Homo sapiens_hsa03018	1.28803164
24	One carbon pool by folate_Homo sapiens_hsa00670	1.26270872
25	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.22127988
26	Phototransduction_Homo sapiens_hsa04744	1.20360698
27	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.13301954
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.11680072
29	Caffeine metabolism_Homo sapiens_hsa00232	1.10132660
30	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.08801182
31	Protein export_Homo sapiens_hsa03060	1.05824480
32	DNA replication_Homo sapiens_hsa03030	1.05554786
33	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.02035691
34	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.01880276
35	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.99099496
36	Fat digestion and absorption_Homo sapiens_hsa04975	0.98647543
37	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.94112124
38	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.93612537
39	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.92758781
40	Purine metabolism_Homo sapiens_hsa00230	0.89265739
41	Tryptophan metabolism_Homo sapiens_hsa00380	0.89136505
42	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.88870700
43	Glycerolipid metabolism_Homo sapiens_hsa00561	0.87655348
44	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.84158076
45	Allograft rejection_Homo sapiens_hsa05330	0.83290291
46	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.81520555
47	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.81116022
48	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.81023658
49	Olfactory transduction_Homo sapiens_hsa04740	0.80818199
50	Folate biosynthesis_Homo sapiens_hsa00790	0.79545604
51	Nucleotide excision repair_Homo sapiens_hsa03420	0.77863136
52	Metabolic pathways_Homo sapiens_hsa01100	0.77333943
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.77078250
54	Basal transcription factors_Homo sapiens_hsa03022	0.76032074
55	Morphine addiction_Homo sapiens_hsa05032	0.74127666
56	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.73786301
57	Butanoate metabolism_Homo sapiens_hsa00650	0.73290744
58	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.72495174
59	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.70834670
60	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.70218901
61	Collecting duct acid secretion_Homo sapiens_hsa04966	0.70107623
62	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.69953445
63	Retinol metabolism_Homo sapiens_hsa00830	0.69352626
64	Steroid biosynthesis_Homo sapiens_hsa00100	0.65633956
65	Fanconi anemia pathway_Homo sapiens_hsa03460	0.64308007
66	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.63400772
67	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.62710773
68	Type I diabetes mellitus_Homo sapiens_hsa04940	0.62614876
69	Serotonergic synapse_Homo sapiens_hsa04726	0.61436964
70	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.61251284
71	Chemical carcinogenesis_Homo sapiens_hsa05204	0.61072927
72	Mismatch repair_Homo sapiens_hsa03430	0.60277232
73	Peroxisome_Homo sapiens_hsa04146	0.59200130
74	Base excision repair_Homo sapiens_hsa03410	0.58680005
75	Rheumatoid arthritis_Homo sapiens_hsa05323	0.57415605
76	Taste transduction_Homo sapiens_hsa04742	0.56371497
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.55937440
78	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.55738187
79	Propanoate metabolism_Homo sapiens_hsa00640	0.53648154
80	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.51906704
81	Graft-versus-host disease_Homo sapiens_hsa05332	0.46961832
82	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.46724618
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.45161602
84	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.44787381
85	Tyrosine metabolism_Homo sapiens_hsa00350	0.44374186
86	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.44271796
87	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.41593777
88	GABAergic synapse_Homo sapiens_hsa04727	0.41425127
89	Cocaine addiction_Homo sapiens_hsa05030	0.37056132
90	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.37025625
91	Spliceosome_Homo sapiens_hsa03040	0.36163484
92	Ether lipid metabolism_Homo sapiens_hsa00565	0.36069807
93	beta-Alanine metabolism_Homo sapiens_hsa00410	0.33077678
94	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.29953207
95	Insulin secretion_Homo sapiens_hsa04911	0.27495970
96	ABC transporters_Homo sapiens_hsa02010	0.27090772
97	RNA transport_Homo sapiens_hsa03013	0.25873649
98	Pyruvate metabolism_Homo sapiens_hsa00620	0.25871295
99	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.25804203
100	p53 signaling pathway_Homo sapiens_hsa04115	0.25121652

RPL5P28

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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