RPL5P29

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)6.51495073
2energy coupled proton transport, down electrochemical gradient (GO:0015985)6.02981276
3ATP synthesis coupled proton transport (GO:0015986)6.02981276
4viral transcription (GO:0019083)5.85433826
5ribosomal small subunit assembly (GO:0000028)5.71131702
6translational termination (GO:0006415)5.62458939
7DNA deamination (GO:0045006)5.58546076
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.40396391
9translational elongation (GO:0006414)5.18878715
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.96217441
11cotranslational protein targeting to membrane (GO:0006613)4.87663351
12protein targeting to ER (GO:0045047)4.85727548
13ribosomal small subunit biogenesis (GO:0042274)4.72120193
14establishment of protein localization to endoplasmic reticulum (GO:0072599)4.63500142
15protein localization to endoplasmic reticulum (GO:0070972)4.60478173
16maturation of SSU-rRNA (GO:0030490)4.39918558
17regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.39702285
18ribosomal large subunit biogenesis (GO:0042273)4.38448143
19protein neddylation (GO:0045116)4.38134289
20tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.28974741
21RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.28974741
22cellular protein complex disassembly (GO:0043624)4.19291372
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.17742443
24viral life cycle (GO:0019058)4.15471504
25translational initiation (GO:0006413)4.00466788
26cytidine metabolic process (GO:0046087)3.94573430
27cytidine catabolic process (GO:0006216)3.94573430
28cytidine deamination (GO:0009972)3.94573430
29respiratory electron transport chain (GO:0022904)3.92690425
30nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.91136283
31establishment of protein localization to mitochondrial membrane (GO:0090151)3.89930834
32electron transport chain (GO:0022900)3.88677011
33nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.81634946
34translation (GO:0006412)3.77221916
35exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.72891966
36protein complex biogenesis (GO:0070271)3.67026643
37water-soluble vitamin biosynthetic process (GO:0042364)3.63080758
38ATP biosynthetic process (GO:0006754)3.58988988
39response to pheromone (GO:0019236)3.58621601
40GDP-mannose metabolic process (GO:0019673)3.54324551
41mitochondrial respiratory chain complex I assembly (GO:0032981)3.54024979
42NADH dehydrogenase complex assembly (GO:0010257)3.54024979
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.54024979
44purine nucleoside triphosphate biosynthetic process (GO:0009145)3.53505907
45purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.51516807
46interferon-gamma production (GO:0032609)3.45719827
47protein complex disassembly (GO:0043241)3.42054933
48cellular component biogenesis (GO:0044085)3.41206069
49nucleoside transmembrane transport (GO:1901642)3.32635095
50regulation of isotype switching to IgG isotypes (GO:0048302)3.32270292
51pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.31539095
52mitochondrial respiratory chain complex assembly (GO:0033108)3.30502835
53pyrimidine ribonucleoside catabolic process (GO:0046133)3.29403607
54GTP biosynthetic process (GO:0006183)3.27854902
55macromolecular complex disassembly (GO:0032984)3.26248780
56ribonucleoprotein complex biogenesis (GO:0022613)3.23032847
57behavioral response to nicotine (GO:0035095)3.22921149
58protein targeting to membrane (GO:0006612)3.22426065
59base-excision repair, AP site formation (GO:0006285)3.17673027
60nuclear-transcribed mRNA catabolic process (GO:0000956)3.05814169
61ribonucleoside triphosphate biosynthetic process (GO:0009201)3.02764203
62rRNA modification (GO:0000154)2.94644974
63rRNA processing (GO:0006364)2.90472042
64hydrogen ion transmembrane transport (GO:1902600)2.88416001
65rRNA metabolic process (GO:0016072)2.88403523
66termination of RNA polymerase III transcription (GO:0006386)2.86926712
67transcription elongation from RNA polymerase III promoter (GO:0006385)2.86926712
68mRNA catabolic process (GO:0006402)2.86546468
69positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.84183602
70deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.81853437
71regulation of cellular amino acid metabolic process (GO:0006521)2.81845154
72regulation of regulatory T cell differentiation (GO:0045589)2.79875444
73proton transport (GO:0015992)2.70844697
74UTP biosynthetic process (GO:0006228)2.70708944
75protein-cofactor linkage (GO:0018065)2.69863959
76ubiquinone biosynthetic process (GO:0006744)2.69093668
77proteasome assembly (GO:0043248)2.68773406
78maturation of 5.8S rRNA (GO:0000460)2.66612888
79hydrogen transport (GO:0006818)2.66359430
80nucleoside triphosphate biosynthetic process (GO:0009142)2.66143285
81pyrimidine nucleotide catabolic process (GO:0006244)2.66131996
82DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.65024713
83negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.64351569
84regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.61678708
85RNA catabolic process (GO:0006401)2.59842343
86protein targeting to mitochondrion (GO:0006626)2.57761942
87UTP metabolic process (GO:0046051)2.56103274
88intracellular protein transmembrane import (GO:0044743)2.55482662
89positive regulation of fatty acid transport (GO:2000193)2.54046885
90signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.53741609
91signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.53741609
92signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.53741609
93pseudouridine synthesis (GO:0001522)2.53056063
94signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.51849904
95intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.51849904
96regulation of chronic inflammatory response (GO:0002676)2.48418222
97guanosine-containing compound biosynthetic process (GO:1901070)2.47442870
98positive regulation of defense response to virus by host (GO:0002230)2.46598103
99deoxyribonucleotide catabolic process (GO:0009264)2.46131504
100positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.44767910

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.52234436
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.89702155
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.56315385
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.51921402
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.48485006
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.34241129
7VDR_22108803_ChIP-Seq_LS180_Human3.31977185
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.26583574
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.15902450
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.01989302
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.89745996
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.81749733
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.78551183
14VDR_23849224_ChIP-Seq_CD4+_Human2.38867843
15EZH2_22144423_ChIP-Seq_EOC_Human2.30905920
16ZNF274_21170338_ChIP-Seq_K562_Hela2.30562908
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.18385817
18NOTCH1_21737748_ChIP-Seq_TLL_Human1.98833399
19FOXP3_21729870_ChIP-Seq_TREG_Human1.96731933
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.87054957
21SRF_21415370_ChIP-Seq_HL-1_Mouse1.82337392
22ELK1_19687146_ChIP-ChIP_HELA_Human1.79135339
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.77613019
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74142689
25MYC_18555785_ChIP-Seq_MESCs_Mouse1.64415473
26IGF1R_20145208_ChIP-Seq_DFB_Human1.62943885
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.61589988
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.58919696
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.57894650
30TP53_22573176_ChIP-Seq_HFKS_Human1.56503860
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.53417349
32MYC_18940864_ChIP-ChIP_HL60_Human1.50548122
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.47159222
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47096497
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.38015760
36TAF15_26573619_Chip-Seq_HEK293_Human1.37518472
37EWS_26573619_Chip-Seq_HEK293_Human1.36156641
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.35668955
39NANOG_20526341_ChIP-Seq_ESCs_Human1.30785327
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28546495
41POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27816364
42TTF2_22483619_ChIP-Seq_HELA_Human1.25491747
43FUS_26573619_Chip-Seq_HEK293_Human1.24527159
44TAF2_19829295_ChIP-Seq_ESCs_Human1.24096976
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23948598
46AR_20517297_ChIP-Seq_VCAP_Human1.23078097
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22688108
48RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.22204240
49BP1_19119308_ChIP-ChIP_Hs578T_Human1.21160692
50NCOR_22424771_ChIP-Seq_293T_Human1.20512109
51GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20244553
52MYC_19829295_ChIP-Seq_ESCs_Human1.17543790
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15872127
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.14691056
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14691056
56EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14578811
57EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.14088699
58GATA3_21878914_ChIP-Seq_MCF-7_Human1.13763770
59GATA3_26560356_Chip-Seq_TH2_Human1.13046008
60CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.12521026
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11954358
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09732791
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09732331
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08006895
65GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.07515515
66XRN2_22483619_ChIP-Seq_HELA_Human1.07139244
67AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06111846
68CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05303068
69ERG_20517297_ChIP-Seq_VCAP_Human1.05179052
70ELK1_22589737_ChIP-Seq_MCF10A_Human1.04101755
71GABP_19822575_ChIP-Seq_HepG2_Human1.00813642
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00658075
73GATA6_21074721_ChIP-Seq_CACO-2_Human1.00438012
74FOXH1_21741376_ChIP-Seq_EPCs_Human0.99846388
75RBPJ_21746931_ChIP-Seq_IB4_Human0.97825006
76TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96125287
77FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94119693
78PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94017631
79PHF8_20622853_ChIP-Seq_HELA_Human0.93894417
80ER_23166858_ChIP-Seq_MCF-7_Human0.92944260
81STAT1_20625510_ChIP-Seq_HELA_Human0.92911235
82FOXH1_21741376_ChIP-Seq_ESCs_Human0.92512790
83RNF2_27304074_Chip-Seq_NSC_Mouse0.91254787
84SOX2_19829295_ChIP-Seq_ESCs_Human0.90487085
85NANOG_19829295_ChIP-Seq_ESCs_Human0.90487085
86DCP1A_22483619_ChIP-Seq_HELA_Human0.90374638
87CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.90246052
88MYC_19079543_ChIP-ChIP_MESCs_Mouse0.89842047
89ERA_21632823_ChIP-Seq_H3396_Human0.89152928
90SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89033393
91ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89023902
92CBX2_27304074_Chip-Seq_ESCs_Mouse0.88972900
93ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88483920
94P53_21459846_ChIP-Seq_SAOS-2_Human0.88417890
95IRF8_22096565_ChIP-ChIP_GC-B_Human0.87835205
96FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87581081
97CTBP2_25329375_ChIP-Seq_LNCAP_Human0.86224485
98E2F1_18555785_ChIP-Seq_MESCs_Mouse0.85812096
99GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.85753937
100ETV1_20927104_ChIP-Seq_GIST48_Human0.85620608

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.47762299
2MP0005671_abnormal_response_to3.19249890
3MP0006292_abnormal_olfactory_placode3.11034132
4MP0002638_abnormal_pupillary_reflex2.97302129
5MP0002102_abnormal_ear_morphology2.64179069
6MP0006072_abnormal_retinal_apoptosis2.50399860
7MP0003646_muscle_fatigue2.42575185
8MP0004145_abnormal_muscle_electrophysio2.39832861
9MP0002837_dystrophic_cardiac_calcinosis2.31951819
10MP0005646_abnormal_pituitary_gland2.22963892
11MP0003878_abnormal_ear_physiology2.15699728
12MP0005377_hearing/vestibular/ear_phenot2.15699728
13MP0001835_abnormal_antigen_presentation2.07495409
14MP0004142_abnormal_muscle_tone1.99526291
15MP0000372_irregular_coat_pigmentation1.96195838
16MP0002163_abnormal_gland_morphology1.88714395
17MP0005645_abnormal_hypothalamus_physiol1.87342856
18MP0005084_abnormal_gallbladder_morpholo1.77975553
19MP0005551_abnormal_eye_electrophysiolog1.77548842
20MP0004885_abnormal_endolymph1.77241538
21MP0008875_abnormal_xenobiotic_pharmacok1.76394350
22MP0008872_abnormal_physiological_respon1.76263105
23MP0001968_abnormal_touch/_nociception1.74964399
24MP0008877_abnormal_DNA_methylation1.74306240
25MP0003011_delayed_dark_adaptation1.68181932
26MP0005389_reproductive_system_phenotype1.67251833
27MP0001986_abnormal_taste_sensitivity1.66164257
28MP0002160_abnormal_reproductive_system1.65342311
29MP0002138_abnormal_hepatobiliary_system1.64755829
30MP0001873_stomach_inflammation1.53834302
31MP0009785_altered_susceptibility_to1.53273756
32MP0009333_abnormal_splenocyte_physiolog1.48136752
33MP0002736_abnormal_nociception_after1.47160826
34MP0002277_abnormal_respiratory_mucosa1.46529364
35MP0001905_abnormal_dopamine_level1.43665775
36MP0004147_increased_porphyrin_level1.40515825
37MP0001919_abnormal_reproductive_system1.40504026
38MP0003787_abnormal_imprinting1.40421211
39MP0002876_abnormal_thyroid_physiology1.38910791
40MP0005379_endocrine/exocrine_gland_phen1.34959099
41MP0008789_abnormal_olfactory_epithelium1.29869827
42MP0003195_calcinosis1.26465894
43MP0005253_abnormal_eye_physiology1.22902583
44MP0002653_abnormal_ependyma_morphology1.20022071
45MP0002148_abnormal_hypersensitivity_rea1.18909409
46MP0002095_abnormal_skin_pigmentation1.16584961
47MP0006276_abnormal_autonomic_nervous1.14840226
48MP0001800_abnormal_humoral_immune1.13687161
49MP0006036_abnormal_mitochondrial_physio1.13505527
50MP0005075_abnormal_melanosome_morpholog1.12896840
51MP0002272_abnormal_nervous_system1.11146898
52MP0005000_abnormal_immune_tolerance1.08097526
53MP0003786_premature_aging1.05668674
54MP0000631_abnormal_neuroendocrine_gland1.03254926
55MP0002723_abnormal_immune_serum1.00640792
56MP0004043_abnormal_pH_regulation0.99837375
57MP0003806_abnormal_nucleotide_metabolis0.99738060
58MP0004133_heterotaxia0.98068502
59MP0003763_abnormal_thymus_physiology0.96947424
60MP0001293_anophthalmia0.95571035
61MP0001485_abnormal_pinna_reflex0.95475897
62MP0003567_abnormal_fetal_cardiomyocyte0.91538239
63MP0009764_decreased_sensitivity_to0.91271916
64MP0001790_abnormal_immune_system0.91052509
65MP0005387_immune_system_phenotype0.91052509
66MP0001984_abnormal_olfaction0.90656195
67MP0001764_abnormal_homeostasis0.90166530
68MP0001529_abnormal_vocalization0.87286467
69MP0002420_abnormal_adaptive_immunity0.86487392
70MP0009745_abnormal_behavioral_response0.86283517
71MP0003880_abnormal_central_pattern0.86072372
72MP0005394_taste/olfaction_phenotype0.84855106
73MP0005499_abnormal_olfactory_system0.84855106
74MP0000049_abnormal_middle_ear0.84598894
75MP0003866_abnormal_defecation0.83620388
76MP0001819_abnormal_immune_cell0.83317383
77MP0005636_abnormal_mineral_homeostasis0.82655702
78MP0001501_abnormal_sleep_pattern0.82309359
79MP0004782_abnormal_surfactant_physiolog0.82128499
80MP0008058_abnormal_DNA_repair0.81951339
81MP0002938_white_spotting0.80963242
82MP0008775_abnormal_heart_ventricle0.80573525
83MP0005195_abnormal_posterior_eye0.80376524
84MP0001970_abnormal_pain_threshold0.79909251
85MP0002733_abnormal_thermal_nociception0.78809344
86MP0006035_abnormal_mitochondrial_morpho0.78191563
87MP0001440_abnormal_grooming_behavior0.77752808
88MP0003693_abnormal_embryo_hatching0.77723448
89MP0002693_abnormal_pancreas_physiology0.77491907
90MP0009250_abnormal_appendicular_skeleto0.76251836
91MP0008995_early_reproductive_senescence0.75860602
92MP0003186_abnormal_redox_activity0.75681353
93MP0001119_abnormal_female_reproductive0.75441764
94MP0005410_abnormal_fertilization0.75275424
95MP0001727_abnormal_embryo_implantation0.72383905
96MP0002210_abnormal_sex_determination0.71075687
97MP0010155_abnormal_intestine_physiology0.70894659
98MP0003137_abnormal_impulse_conducting0.70239508
99MP0002398_abnormal_bone_marrow0.69161290
100MP0002752_abnormal_somatic_nervous0.69098152

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.44187689
2Mitochondrial inheritance (HP:0001427)4.33091521
3Abnormal mitochondria in muscle tissue (HP:0008316)3.93877121
4Increased hepatocellular lipid droplets (HP:0006565)3.91772289
5Increased CSF lactate (HP:0002490)3.91253760
63-Methylglutaconic aciduria (HP:0003535)3.87844147
7Progressive macrocephaly (HP:0004481)3.67912032
8Congenital stationary night blindness (HP:0007642)3.63572571
9Acute encephalopathy (HP:0006846)3.62780223
10Absent rod-and cone-mediated responses on ERG (HP:0007688)3.48661975
11Methylmalonic acidemia (HP:0002912)3.45731777
12Lipid accumulation in hepatocytes (HP:0006561)3.44947480
13Hepatocellular necrosis (HP:0001404)3.39208979
14Abnormality of cells of the erythroid lineage (HP:0012130)3.37693671
15Elevated erythrocyte sedimentation rate (HP:0003565)3.37038699
16Abnormality of midbrain morphology (HP:0002418)3.35423182
17Molar tooth sign on MRI (HP:0002419)3.35423182
18Renal Fanconi syndrome (HP:0001994)3.28022787
19Macrocytic anemia (HP:0001972)3.18504789
20Pancreatic cysts (HP:0001737)3.14650550
21Hepatic necrosis (HP:0002605)3.11091742
22Increased intramyocellular lipid droplets (HP:0012240)3.05280448
23Abnormal rod and cone electroretinograms (HP:0008323)3.02460378
24Cerebral edema (HP:0002181)2.97119441
25Pancreatic fibrosis (HP:0100732)2.94765533
26Abnormal number of erythroid precursors (HP:0012131)2.79807483
27IgG deficiency (HP:0004315)2.78768985
28Exertional dyspnea (HP:0002875)2.73376892
29True hermaphroditism (HP:0010459)2.71467318
30Methylmalonic aciduria (HP:0012120)2.67756077
31Abolished electroretinogram (ERG) (HP:0000550)2.64093022
32Decreased central vision (HP:0007663)2.63432642
33Stomatitis (HP:0010280)2.59191743
34Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.59148852
35Pallor (HP:0000980)2.55533244
36Optic disc pallor (HP:0000543)2.54328613
37Increased serum lactate (HP:0002151)2.52504449
38Abnormality of the phalanges of the 2nd finger (HP:0009541)2.50780102
39Lactic acidosis (HP:0003128)2.45055520
40Increased muscle lipid content (HP:0009058)2.42625748
41Aplastic anemia (HP:0001915)2.42038424
42Dynein arm defect of respiratory motile cilia (HP:0012255)2.39071201
43Absent/shortened dynein arms (HP:0200106)2.39071201
44Reticulocytopenia (HP:0001896)2.35199036
45Nephronophthisis (HP:0000090)2.34694790
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.32510464
47Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.32510464
48Hypoproteinemia (HP:0003075)2.24720681
49Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.22896982
50Decreased electroretinogram (ERG) amplitude (HP:0000654)2.22118634
51Abnormality of renal resorption (HP:0011038)2.19975135
52Glycosuria (HP:0003076)2.17239783
53Abnormality of urine glucose concentration (HP:0011016)2.17239783
54Congenital, generalized hypertrichosis (HP:0004540)2.16589797
55Abnormality of the renal cortex (HP:0011035)2.16249459
56Hyperphosphaturia (HP:0003109)2.15109126
57Abnormal drinking behavior (HP:0030082)2.13615969
58Polydipsia (HP:0001959)2.13615969
59Exercise intolerance (HP:0003546)2.09391066
60Respiratory failure (HP:0002878)2.08959576
61Type 2 muscle fiber atrophy (HP:0003554)2.07165444
62Hyperglycinemia (HP:0002154)2.06133002
63Medial flaring of the eyebrow (HP:0010747)2.05889961
64Abnormal respiratory motile cilium morphology (HP:0005938)2.05595155
65Abnormal respiratory epithelium morphology (HP:0012253)2.05595155
66Hypoplasia of the pons (HP:0012110)2.05091732
67Absent thumb (HP:0009777)2.05088483
68Abnormality of the vitamin B12 metabolism (HP:0004341)2.03019068
69Lethargy (HP:0001254)2.02092711
70Attenuation of retinal blood vessels (HP:0007843)2.01835738
71Respiratory difficulties (HP:0002880)2.01484911
72Abnormality of the renal medulla (HP:0100957)1.97599776
73Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.96683073
74Abnormality of alanine metabolism (HP:0010916)1.96683073
75Hyperalaninemia (HP:0003348)1.96683073
76Renal cortical cysts (HP:0000803)1.96594130
77Ketosis (HP:0001946)1.95948393
78Dyskinesia (HP:0100660)1.95372618
79Abnormality of the pons (HP:0007361)1.93993838
80Type II lissencephaly (HP:0007260)1.92890006
81Abnormality of vitamin B metabolism (HP:0004340)1.92837318
82Stenosis of the external auditory canal (HP:0000402)1.91806338
83Colon cancer (HP:0003003)1.91599982
84Pendular nystagmus (HP:0012043)1.90040808
85Sclerocornea (HP:0000647)1.88174800
86Abnormal hemoglobin (HP:0011902)1.87654698
87Severe combined immunodeficiency (HP:0004430)1.87416560
88Abnormality of magnesium homeostasis (HP:0004921)1.86123163
89Cystic liver disease (HP:0006706)1.85436986
90Constricted visual fields (HP:0001133)1.83251145
91Agitation (HP:0000713)1.82413079
92CNS demyelination (HP:0007305)1.81833820
93Increased IgM level (HP:0003496)1.81769010
94Type I transferrin isoform profile (HP:0003642)1.80604482
95Polyuria (HP:0000103)1.78962060
96Microretrognathia (HP:0000308)1.78677768
97Muscle fiber atrophy (HP:0100295)1.77911935
98Aplasia/hypoplasia of the uterus (HP:0008684)1.76471195
99Leukodystrophy (HP:0002415)1.76027284
100Reduced antithrombin III activity (HP:0001976)1.74737853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.67742006
2BCKDK3.31380841
3TLK13.13201806
4ZAK2.66604325
5WNK42.45801192
6ADRBK22.41843071
7TIE12.36307854
8MAP4K22.16987631
9GRK12.12657733
10KDR2.11522501
11PASK2.02370667
12TAOK31.91288841
13VRK21.86865225
14NUAK11.86552368
15CDK191.77995409
16CAMKK21.76502550
17PINK11.75744234
18FRK1.69346942
19STK161.61239083
20STK391.57494525
21FES1.45392015
22WNK31.39735039
23MAP3K121.38361898
24TESK21.37099349
25VRK11.36300324
26TEC1.35259209
27ITK1.33727076
28EIF2AK31.28306682
29LIMK11.24620692
30PHKG21.22616070
31PHKG11.22616070
32NME21.20637956
33PDK21.19412516
34MAP2K61.10952229
35INSRR1.09186041
36NME11.08498848
37BMPR1B1.05687086
38SYK1.05066329
39CAMKK11.03702678
40MAP4K11.03675598
41IKBKB1.02968033
42OBSCN0.99904680
43GRK60.98067470
44RPS6KA50.95869301
45DYRK20.94946303
46MUSK0.94714182
47BTK0.94696826
48BUB10.92996274
49SCYL20.92570766
50OXSR10.91894249
51LCK0.88835071
52PRKCQ0.87261612
53KIT0.87087765
54TRIM280.85624146
55PIK3CG0.85421477
56PLK40.81509858
57DAPK20.79898041
58PIK3CA0.77406889
59EIF2AK10.76891747
60IKBKE0.76462703
61PIM10.73607271
62MAP2K70.70660179
63ADRBK10.70503003
64ABL20.65162593
65MAP2K20.61340679
66MAPK130.60248850
67MAP3K40.60190600
68WNK10.59231985
69MAP3K110.57708120
70CSNK2A10.56726349
71LYN0.55800393
72DAPK10.55196005
73CSNK2A20.54351745
74RPS6KA60.54317990
75PIM20.54302255
76TNK20.52272003
77PRKACA0.51686921
78GRK70.50587814
79CAMK10.50137700
80CSF1R0.48612140
81CSNK1G30.48263763
82PRKCA0.48251045
83ATR0.47285378
84PRKCG0.45537309
85CAMK2A0.44460638
86PLK30.43243179
87PRKCE0.41502015
88DAPK30.40958716
89CDC70.40429353
90AURKA0.40027777
91MYLK0.39901133
92RPS6KC10.39440416
93RPS6KL10.39440416
94BMPR20.39070635
95CSNK1G20.38649266
96IGF1R0.38647238
97PRKCD0.37236139
98PLK10.36549526
99CSNK1G10.36358650
100AURKB0.34578505

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.31040278
2Oxidative phosphorylation_Homo sapiens_hsa001903.92138312
3Proteasome_Homo sapiens_hsa030503.72920494
4Parkinsons disease_Homo sapiens_hsa050123.16727384
5RNA polymerase_Homo sapiens_hsa030202.39983822
6Asthma_Homo sapiens_hsa053102.20845696
7Allograft rejection_Homo sapiens_hsa053302.11550252
8Alzheimers disease_Homo sapiens_hsa050102.11316052
9Primary immunodeficiency_Homo sapiens_hsa053402.08322852
10Huntingtons disease_Homo sapiens_hsa050162.05180173
11Protein export_Homo sapiens_hsa030602.04831377
12Autoimmune thyroid disease_Homo sapiens_hsa053202.02167732
13Cardiac muscle contraction_Homo sapiens_hsa042601.99254611
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.93046394
15Phototransduction_Homo sapiens_hsa047441.89646314
16Linoleic acid metabolism_Homo sapiens_hsa005911.83739386
17Graft-versus-host disease_Homo sapiens_hsa053321.79432176
18Type I diabetes mellitus_Homo sapiens_hsa049401.79136878
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.71807960
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.68338718
21One carbon pool by folate_Homo sapiens_hsa006701.62268921
22RNA degradation_Homo sapiens_hsa030181.61624897
23Caffeine metabolism_Homo sapiens_hsa002321.59013669
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54658892
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54341303
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52180059
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.49453646
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44397710
29Nitrogen metabolism_Homo sapiens_hsa009101.41647878
30Homologous recombination_Homo sapiens_hsa034401.34527629
31Basal transcription factors_Homo sapiens_hsa030221.29999791
32Regulation of autophagy_Homo sapiens_hsa041401.26601895
33Pyrimidine metabolism_Homo sapiens_hsa002401.19944600
34Sulfur metabolism_Homo sapiens_hsa009201.10064303
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.09318446
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05956442
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03999230
38Purine metabolism_Homo sapiens_hsa002301.02971673
39Hematopoietic cell lineage_Homo sapiens_hsa046401.02137469
40Ether lipid metabolism_Homo sapiens_hsa005651.00468644
41Tryptophan metabolism_Homo sapiens_hsa003800.99714101
42Propanoate metabolism_Homo sapiens_hsa006400.96924705
43Peroxisome_Homo sapiens_hsa041460.96094254
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.95597213
45Fanconi anemia pathway_Homo sapiens_hsa034600.94167554
46Antigen processing and presentation_Homo sapiens_hsa046120.91909642
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90913380
48Nucleotide excision repair_Homo sapiens_hsa034200.88809608
49Rheumatoid arthritis_Homo sapiens_hsa053230.87949673
50Mismatch repair_Homo sapiens_hsa034300.86689505
51Base excision repair_Homo sapiens_hsa034100.81235282
52Arachidonic acid metabolism_Homo sapiens_hsa005900.78819211
53Olfactory transduction_Homo sapiens_hsa047400.78607162
54Butanoate metabolism_Homo sapiens_hsa006500.76502625
55Sulfur relay system_Homo sapiens_hsa041220.75867806
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73791983
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73452442
58Selenocompound metabolism_Homo sapiens_hsa004500.73432623
59Retinol metabolism_Homo sapiens_hsa008300.73427038
60Spliceosome_Homo sapiens_hsa030400.70009676
61DNA replication_Homo sapiens_hsa030300.69934716
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67303912
63Systemic lupus erythematosus_Homo sapiens_hsa053220.65972808
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.65364631
65Metabolic pathways_Homo sapiens_hsa011000.64921630
66Chemical carcinogenesis_Homo sapiens_hsa052040.64368340
67RNA transport_Homo sapiens_hsa030130.63882122
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.63174986
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58961221
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58686922
71Fat digestion and absorption_Homo sapiens_hsa049750.58304114
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58210198
73Nicotine addiction_Homo sapiens_hsa050330.55649302
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54403805
75T cell receptor signaling pathway_Homo sapiens_hsa046600.54194778
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52564747
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51308866
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51048467
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51015683
80Folate biosynthesis_Homo sapiens_hsa007900.47832230
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46829176
82Collecting duct acid secretion_Homo sapiens_hsa049660.46100353
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45524178
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42707366
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.42255078
86Taste transduction_Homo sapiens_hsa047420.38330301
87Viral myocarditis_Homo sapiens_hsa054160.37820238
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.37666213
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36980225
90Morphine addiction_Homo sapiens_hsa050320.35033698
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26370369
92Pyruvate metabolism_Homo sapiens_hsa006200.24627115
93Ovarian steroidogenesis_Homo sapiens_hsa049130.21939389
94Measles_Homo sapiens_hsa051620.18569972
95Vitamin digestion and absorption_Homo sapiens_hsa049770.18492941
96Malaria_Homo sapiens_hsa051440.18379463
97Mineral absorption_Homo sapiens_hsa049780.18057654
98Hedgehog signaling pathway_Homo sapiens_hsa043400.17441155
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17086128
100Serotonergic synapse_Homo sapiens_hsa047260.16802210

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