ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.71920785
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.69250369
3	ATP synthesis coupled proton transport (GO:0015986)	5.69250369
4	viral transcription (GO:0019083)	5.38470876
5	ribosomal small subunit assembly (GO:0000028)	5.23330655
6	translational termination (GO:0006415)	5.21816862
7	chaperone-mediated protein transport (GO:0072321)	4.83690607
8	DNA deamination (GO:0045006)	4.66532071
9	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.64624179
10	cotranslational protein targeting to membrane (GO:0006613)	4.55197548
11	protein targeting to ER (GO:0045047)	4.50129197
12	translational elongation (GO:0006414)	4.44512859
13	ribosomal large subunit biogenesis (GO:0042273)	4.39337744
14	protein neddylation (GO:0045116)	4.36794425
15	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.30402392
16	protein localization to endoplasmic reticulum (GO:0070972)	4.27142042
17	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.22715370
18	cellular protein complex disassembly (GO:0043624)	3.86515840
19	electron transport chain (GO:0022900)	3.85821964
20	respiratory electron transport chain (GO:0022904)	3.85702811
21	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.80505600
22	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.80505600
23	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.73435885
24	viral life cycle (GO:0019058)	3.69729184
25	maturation of SSU-rRNA (GO:0030490)	3.66045180
26	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.58454900
27	translational initiation (GO:0006413)	3.56137387
28	protein complex biogenesis (GO:0070271)	3.47849821
29	behavioral response to nicotine (GO:0035095)	3.40615357
30	base-excision repair, AP site formation (GO:0006285)	3.38348535
31	platelet dense granule organization (GO:0060155)	3.35906560
32	ATP biosynthetic process (GO:0006754)	3.31730444
33	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.31163540
34	GTP biosynthetic process (GO:0006183)	3.29368345
35	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.28298938
36	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.25754363
37	NADH dehydrogenase complex assembly (GO:0010257)	3.25754363
38	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.25754363
39	kynurenine metabolic process (GO:0070189)	3.15727678
40	translation (GO:0006412)	3.14717182
41	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.13849815
42	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.10361063
43	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.07834309
44	mitochondrial respiratory chain complex assembly (GO:0033108)	3.05886603
45	protein complex disassembly (GO:0043241)	3.05478933
46	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	3.05193225
47	hydrogen ion transmembrane transport (GO:1902600)	3.00672059
48	ribosomal small subunit biogenesis (GO:0042274)	2.99146656
49	GPI anchor metabolic process (GO:0006505)	2.97657368
50	macromolecular complex disassembly (GO:0032984)	2.94140508
51	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.93575733
52	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.88869409
53	protein targeting to membrane (GO:0006612)	2.87312648
54	tryptophan catabolic process (GO:0006569)	2.87131510
55	indole-containing compound catabolic process (GO:0042436)	2.87131510
56	indolalkylamine catabolic process (GO:0046218)	2.87131510
57	water-soluble vitamin biosynthetic process (GO:0042364)	2.87060819
58	GPI anchor biosynthetic process (GO:0006506)	2.85280191
59	proton transport (GO:0015992)	2.84121993
60	regulation of isotype switching to IgG isotypes (GO:0048302)	2.83158850
61	hydrogen transport (GO:0006818)	2.78934068
62	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.78903640
63	negative regulation of heart rate (GO:0010459)	2.77475791
64	regulation of cilium movement (GO:0003352)	2.77462669
65	UTP metabolic process (GO:0046051)	2.76628900
66	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.73251688
67	cytidine catabolic process (GO:0006216)	2.72562871
68	cytidine deamination (GO:0009972)	2.72562871
69	cytidine metabolic process (GO:0046087)	2.72562871
70	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.71165155
71	deoxyribose phosphate catabolic process (GO:0046386)	2.70770186
72	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.69642033
73	termination of RNA polymerase III transcription (GO:0006386)	2.69642033
74	deoxyribonucleotide catabolic process (GO:0009264)	2.68948283
75	preassembly of GPI anchor in ER membrane (GO:0016254)	2.68241129
76	UTP biosynthetic process (GO:0006228)	2.62361393
77	proteasome assembly (GO:0043248)	2.62308030
78	respiratory chain complex IV assembly (GO:0008535)	2.62070948
79	aldehyde catabolic process (GO:0046185)	2.60955806
80	indolalkylamine metabolic process (GO:0006586)	2.58472598
81	positive regulation of interleukin-17 production (GO:0032740)	2.57799078
82	positive regulation of T-helper 1 type immune response (GO:0002827)	2.57281323
83	purine deoxyribonucleotide catabolic process (GO:0009155)	2.52258441
84	mRNA catabolic process (GO:0006402)	2.52029301
85	tryptophan metabolic process (GO:0006568)	2.51961712
86	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.50131700
87	axoneme assembly (GO:0035082)	2.50043650
88	iron-sulfur cluster assembly (GO:0016226)	2.49359837
89	metallo-sulfur cluster assembly (GO:0031163)	2.49359837
90	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.46003455
91	sequestering of actin monomers (GO:0042989)	2.44536120
92	nucleoside triphosphate biosynthetic process (GO:0009142)	2.44164286
93	pyrimidine nucleotide catabolic process (GO:0006244)	2.41162142
94	mannosylation (GO:0097502)	2.40790103
95	phosphatidylcholine acyl-chain remodeling (GO:0036151)	2.40593817
96	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.39517489
97	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.35823898
98	cytochrome complex assembly (GO:0017004)	2.34441026
99	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.32982870
100	cellular component biogenesis (GO:0044085)	2.32085060

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.44185789
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.14454810
3	VDR_22108803_ChIP-Seq_LS180_Human	2.97328393
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.66715820
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.60866773
6	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.58013197
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.54875289
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.47992143
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.43164501
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.22391406
11	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.16779648
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.16371794
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.06868275
14	EWS_26573619_Chip-Seq_HEK293_Human	2.04408556
15	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.04318406
16	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.98047415
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.96850676
18	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.92560811
19	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.84899155
20	TAF15_26573619_Chip-Seq_HEK293_Human	1.84870787
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.84315360
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.79645937
23	FUS_26573619_Chip-Seq_HEK293_Human	1.79262698
24	ELK1_19687146_ChIP-ChIP_HELA_Human	1.78067800
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.77127867
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.73222326
27	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.72199915
28	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.71582807
29	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.69247533
30	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.64672582
31	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.64060167
32	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.60395006
33	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.59820451
34	P300_19829295_ChIP-Seq_ESCs_Human	1.59600266
35	FOXP3_21729870_ChIP-Seq_TREG_Human	1.57129185
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.55516509
37	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.54579973
38	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.52724405
39	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.52724405
40	MYC_18940864_ChIP-ChIP_HL60_Human	1.47811499
41	AR_20517297_ChIP-Seq_VCAP_Human	1.43065144
42	NANOG_19829295_ChIP-Seq_ESCs_Human	1.42833707
43	SOX2_19829295_ChIP-Seq_ESCs_Human	1.42833707
44	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.42361402
45	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.38884228
46	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.38327298
47	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.37259279
48	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.36393948
49	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.36258983
50	CBP_20019798_ChIP-Seq_JUKART_Human	1.34478923
51	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.34478923
52	IRF1_19129219_ChIP-ChIP_H3396_Human	1.32390565
53	GATA3_26560356_Chip-Seq_TH2_Human	1.32152729
54	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.29007464
55	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28882348
56	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.28830747
57	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.28728854
58	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.27443942
59	GBX2_23144817_ChIP-Seq_PC3_Human	1.27072747
60	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.26960625
61	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.25044293
62	NCOR_22424771_ChIP-Seq_293T_Human	1.24950272
63	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.22102826
64	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.21120354
65	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.20974316
66	TAF2_19829295_ChIP-Seq_ESCs_Human	1.19381241
67	NANOG_20526341_ChIP-Seq_ESCs_Human	1.17614123
68	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.16649446
69	TCF4_22108803_ChIP-Seq_LS180_Human	1.15486945
70	BCAT_22108803_ChIP-Seq_LS180_Human	1.15315237
71	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.15234554
72	RNF2_27304074_Chip-Seq_NSC_Mouse	1.13822671
73	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.13715237
74	ERG_20517297_ChIP-Seq_VCAP_Human	1.12780595
75	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.12607341
76	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.11428470
77	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.10261084
78	MYC_19829295_ChIP-Seq_ESCs_Human	1.08549895
79	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.06439135
80	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.05737007
81	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.04953194
82	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.03874589
83	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.02770653
84	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.01533367
85	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.01316895
86	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01146961
87	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.00706898
88	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.97957885
89	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.95802395
90	HTT_18923047_ChIP-ChIP_STHdh_Human	0.94286684
91	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.93781606
92	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.92864494
93	MYB_26560356_Chip-Seq_TH2_Human	0.92610758
94	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.91775670
95	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.91354905
96	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.90997143
97	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.90400931
98	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.89813654
99	P53_22387025_ChIP-Seq_ESCs_Mouse	0.89350831
100	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.87842874

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.54147210
2	MP0005671_abnormal_response_to	3.12012490
3	MP0001835_abnormal_antigen_presentation	2.89223791
4	MP0006292_abnormal_olfactory_placode	2.49956290
5	MP0002837_dystrophic_cardiac_calcinosis	2.26709804
6	MP0006072_abnormal_retinal_apoptosis	2.18634624
7	MP0004142_abnormal_muscle_tone	2.08233717
8	MP0003646_muscle_fatigue	2.05424700
9	MP0005551_abnormal_eye_electrophysiolog	2.02595705
10	MP0008872_abnormal_physiological_respon	2.01822687
11	MP0003878_abnormal_ear_physiology	1.98665718
12	MP0005377_hearing/vestibular/ear_phenot	1.98665718
13	MP0000372_irregular_coat_pigmentation	1.97952220
14	MP0003011_delayed_dark_adaptation	1.91506667
15	MP0005645_abnormal_hypothalamus_physiol	1.87818705
16	MP0004885_abnormal_endolymph	1.82416028
17	MP0002102_abnormal_ear_morphology	1.81304392
18	MP0008877_abnormal_DNA_methylation	1.74667864
19	MP0009785_altered_susceptibility_to	1.74192842
20	MP0008875_abnormal_xenobiotic_pharmacok	1.73428788
21	MP0005646_abnormal_pituitary_gland	1.73070477
22	MP0001873_stomach_inflammation	1.72086800
23	MP0005084_abnormal_gallbladder_morpholo	1.62993411
24	MP0004145_abnormal_muscle_electrophysio	1.60196093
25	MP0001986_abnormal_taste_sensitivity	1.53148046
26	MP0003195_calcinosis	1.48528273
27	MP0001800_abnormal_humoral_immune	1.47526156
28	MP0001968_abnormal_touch/_nociception	1.46859028
29	MP0005075_abnormal_melanosome_morpholog	1.46301658
30	MP0002736_abnormal_nociception_after	1.40579860
31	MP0002876_abnormal_thyroid_physiology	1.39106677
32	MP0005389_reproductive_system_phenotype	1.37535942
33	MP0001485_abnormal_pinna_reflex	1.36681518
34	MP0002148_abnormal_hypersensitivity_rea	1.36626704
35	MP0002160_abnormal_reproductive_system	1.33296209
36	MP0009764_decreased_sensitivity_to	1.32960931
37	MP0005253_abnormal_eye_physiology	1.32022358
38	MP0002272_abnormal_nervous_system	1.29573511
39	MP0005174_abnormal_tail_pigmentation	1.28030119
40	MP0008789_abnormal_olfactory_epithelium	1.27932768
41	MP0002166_altered_tumor_susceptibility	1.27555052
42	MP0009333_abnormal_splenocyte_physiolog	1.27126998
43	MP0006276_abnormal_autonomic_nervous	1.26744620
44	MP0001905_abnormal_dopamine_level	1.25442105
45	MP0002653_abnormal_ependyma_morphology	1.24960945
46	MP0005000_abnormal_immune_tolerance	1.24055065
47	MP0010386_abnormal_urinary_bladder	1.23755157
48	MP0002163_abnormal_gland_morphology	1.22155539
49	MP0003806_abnormal_nucleotide_metabolis	1.22031318
50	MP0001529_abnormal_vocalization	1.15916346
51	MP0002723_abnormal_immune_serum	1.15773731
52	MP0003724_increased_susceptibility_to	1.15240495
53	MP0002006_tumorigenesis	1.13495444
54	MP0001919_abnormal_reproductive_system	1.13405343
55	MP0005085_abnormal_gallbladder_physiolo	1.13396055
56	MP0003787_abnormal_imprinting	1.12866281
57	MP0003763_abnormal_thymus_physiology	1.11415044
58	MP0002638_abnormal_pupillary_reflex	1.11257614
59	MP0000631_abnormal_neuroendocrine_gland	1.09342375
60	MP0003880_abnormal_central_pattern	1.08986169
61	MP0002138_abnormal_hepatobiliary_system	1.08934781
62	MP0002095_abnormal_skin_pigmentation	1.08850757
63	MP0008995_early_reproductive_senescence	1.07758364
64	MP0001440_abnormal_grooming_behavior	1.05048698
65	MP0009745_abnormal_behavioral_response	1.04831234
66	MP0005387_immune_system_phenotype	1.04028430
67	MP0001790_abnormal_immune_system	1.04028430
68	MP0006036_abnormal_mitochondrial_physio	1.01622695
69	MP0005636_abnormal_mineral_homeostasis	1.00348419
70	MP0004147_increased_porphyrin_level	0.99824006
71	MP0009046_muscle_twitch	0.99468109
72	MP0002452_abnormal_antigen_presenting	0.98734612
73	MP0000685_abnormal_immune_system	0.98563472
74	MP0001486_abnormal_startle_reflex	0.98328854
75	MP0002420_abnormal_adaptive_immunity	0.98233492
76	MP0005379_endocrine/exocrine_gland_phen	0.97607825
77	MP0001819_abnormal_immune_cell	0.97591002
78	MP0003137_abnormal_impulse_conducting	0.96283075
79	MP0004782_abnormal_surfactant_physiolog	0.94822815
80	MP0005394_taste/olfaction_phenotype	0.91816577
81	MP0005499_abnormal_olfactory_system	0.91816577
82	MP0003136_yellow_coat_color	0.91671125
83	MP0001765_abnormal_ion_homeostasis	0.90018376
84	MP0005025_abnormal_response_to	0.88475390
85	MP0001663_abnormal_digestive_system	0.86857083
86	MP0001501_abnormal_sleep_pattern	0.86271560
87	MP0004742_abnormal_vestibular_system	0.83728229
88	MP0001188_hyperpigmentation	0.82970411
89	MP0003186_abnormal_redox_activity	0.81710471
90	MP0010155_abnormal_intestine_physiology	0.80641177
91	MP0001970_abnormal_pain_threshold	0.77737346
92	MP0001764_abnormal_homeostasis	0.77544515
93	MP0000516_abnormal_urinary_system	0.75420376
94	MP0005367_renal/urinary_system_phenotyp	0.75420376
95	MP0000049_abnormal_middle_ear	0.74952349
96	MP0002572_abnormal_emotion/affect_behav	0.73655756
97	MP0005670_abnormal_white_adipose	0.73553010
98	MP0001963_abnormal_hearing_physiology	0.72892539
99	MP0000716_abnormal_immune_system	0.72517082
100	MP0002938_white_spotting	0.71699624

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.10141685
2	Mitochondrial inheritance (HP:0001427)	3.77710857
3	Lipid accumulation in hepatocytes (HP:0006561)	3.74312991
4	Acute necrotizing encephalopathy (HP:0006965)	3.65026439
5	Congenital stationary night blindness (HP:0007642)	3.57121486
6	Increased hepatocellular lipid droplets (HP:0006565)	3.55615847
7	Abnormal rod and cone electroretinograms (HP:0008323)	3.46745226
8	Increased CSF lactate (HP:0002490)	3.38801653
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.24479594
10	Molar tooth sign on MRI (HP:0002419)	3.22794374
11	Abnormality of midbrain morphology (HP:0002418)	3.22794374
12	Hepatocellular necrosis (HP:0001404)	3.16626618
13	Congenital, generalized hypertrichosis (HP:0004540)	3.14027612
14	Progressive macrocephaly (HP:0004481)	3.13958033
15	3-Methylglutaconic aciduria (HP:0003535)	3.12953354
16	Acute encephalopathy (HP:0006846)	3.07237738
17	Pancreatic cysts (HP:0001737)	2.97617773
18	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.92464762
19	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.92464762
20	Hepatic necrosis (HP:0002605)	2.90670307
21	Renal Fanconi syndrome (HP:0001994)	2.89464615
22	Macrocytic anemia (HP:0001972)	2.87149616
23	Absent/shortened dynein arms (HP:0200106)	2.85881008
24	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.85881008
25	Hypoproteinemia (HP:0003075)	2.83695678
26	Abolished electroretinogram (ERG) (HP:0000550)	2.82446587
27	Decreased central vision (HP:0007663)	2.80680278
28	Increased intramyocellular lipid droplets (HP:0012240)	2.77700942
29	IgG deficiency (HP:0004315)	2.77683765
30	Methylmalonic acidemia (HP:0002912)	2.76834761
31	Severe combined immunodeficiency (HP:0004430)	2.76165352
32	Exertional dyspnea (HP:0002875)	2.71973095
33	Attenuation of retinal blood vessels (HP:0007843)	2.70062349
34	Increased muscle lipid content (HP:0009058)	2.63001608
35	Pancreatic fibrosis (HP:0100732)	2.62703357
36	Reticulocytopenia (HP:0001896)	2.62676857
37	True hermaphroditism (HP:0010459)	2.62468269
38	Optic disc pallor (HP:0000543)	2.58460128
39	Medial flaring of the eyebrow (HP:0010747)	2.57231438
40	Thyroiditis (HP:0100646)	2.51823071
41	Elevated erythrocyte sedimentation rate (HP:0003565)	2.47392980
42	Abnormality of cells of the erythroid lineage (HP:0012130)	2.43950844
43	Pallor (HP:0000980)	2.43559351
44	Panhypogammaglobulinemia (HP:0003139)	2.41161563
45	Abnormal respiratory epithelium morphology (HP:0012253)	2.39877072
46	Abnormal respiratory motile cilium morphology (HP:0005938)	2.39877072
47	Abnormality of B cell number (HP:0010975)	2.37586972
48	Constricted visual fields (HP:0001133)	2.31859270
49	Methylmalonic aciduria (HP:0012120)	2.31528184
50	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.30576236
51	Renal cortical cysts (HP:0000803)	2.29591021
52	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.28446264
53	B lymphocytopenia (HP:0010976)	2.28419000
54	Nephronophthisis (HP:0000090)	2.28144205
55	Cerebral edema (HP:0002181)	2.26341649
56	Abnormal ciliary motility (HP:0012262)	2.19848264
57	Increased serum lactate (HP:0002151)	2.18803972
58	Abnormal respiratory motile cilium physiology (HP:0012261)	2.17505987
59	Abnormal number of erythroid precursors (HP:0012131)	2.17366508
60	Lactic acidosis (HP:0003128)	2.16905230
61	Abnormality of the renal cortex (HP:0011035)	2.15461463
62	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.15281450
63	Congenital primary aphakia (HP:0007707)	2.12756819
64	Stomatitis (HP:0010280)	2.12583407
65	Stenosis of the external auditory canal (HP:0000402)	2.12404118
66	Gait imbalance (HP:0002141)	2.11782304
67	Nephrogenic diabetes insipidus (HP:0009806)	2.09362073
68	Aplastic anemia (HP:0001915)	2.08777792
69	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.07842819
70	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.07208242
71	Abnormality of macular pigmentation (HP:0008002)	2.07204034
72	Abnormality of urine glucose concentration (HP:0011016)	2.05629333
73	Glycosuria (HP:0003076)	2.05629333
74	Abnormality of renal resorption (HP:0011038)	2.03383330
75	Respiratory difficulties (HP:0002880)	1.99965113
76	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.99223280
77	Abnormality of the prostate (HP:0008775)	1.97735687
78	Abnormality of eosinophils (HP:0001879)	1.96998060
79	Sclerocornea (HP:0000647)	1.92964477
80	Combined immunodeficiency (HP:0005387)	1.90217212
81	Lethargy (HP:0001254)	1.90135769
82	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.90050351
83	Abnormal hemoglobin (HP:0011902)	1.89297189
84	Respiratory failure (HP:0002878)	1.88793116
85	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.88780633
86	Abnormality of alanine metabolism (HP:0010916)	1.88780633
87	Hyperalaninemia (HP:0003348)	1.88780633
88	Dyskinesia (HP:0100660)	1.88277917
89	Abnormality of the renal medulla (HP:0100957)	1.87942792
90	Type II lissencephaly (HP:0007260)	1.87237353
91	Pendular nystagmus (HP:0012043)	1.86988951
92	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.85336182
93	Hyperglycinemia (HP:0002154)	1.85157065
94	Dicarboxylic aciduria (HP:0003215)	1.81414288
95	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.81414288
96	Asplenia (HP:0001746)	1.81214028
97	Hyperphosphaturia (HP:0003109)	1.79965778
98	Colon cancer (HP:0003003)	1.79275864
99	Type 2 muscle fiber atrophy (HP:0003554)	1.76869482
100	Abnormal drinking behavior (HP:0030082)	1.75605861

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.52855377
2	TLK1	3.05777085
3	ADRBK2	3.02939969
4	CDK19	2.94768983
5	TXK	2.62498424
6	GRK1	2.35008577
7	ZAK	2.33839811
8	FRK	2.22182034
9	MAP3K12	1.96461082
10	TAOK3	1.94115688
11	WNK4	1.93259788
12	BMPR2	1.87939778
13	BCKDK	1.79328024
14	KDR	1.76976948
15	NUAK1	1.71061843
16	STK16	1.57170728
17	TEC	1.49763088
18	WNK3	1.43419407
19	PINK1	1.42881632
20	KIT	1.41124929
21	INSRR	1.40271706
22	VRK2	1.39714729
23	OXSR1	1.37493930
24	SCYL2	1.35151240
25	NEK1	1.33930368
26	SYK	1.24829783
27	ITK	1.21225252
28	CSF1R	1.19869739
29	DAPK2	1.19648001
30	MAP4K1	1.16281167
31	VRK1	1.13791651
32	GRK6	1.11988501
33	STK39	1.11305081
34	PASK	1.08525645
35	EIF2AK3	1.08304577
36	IKBKB	1.08027786
37	TRPM7	1.07551034
38	BMPR1B	1.06914108
39	FLT3	1.05122316
40	DYRK2	1.04238624
41	RPS6KA4	1.03457799
42	MYLK	1.02738812
43	TRIM28	1.02468732
44	CSNK1G3	1.02010878
45	MAPK13	0.99701211
46	ERBB3	0.99599851
47	CSNK1G1	0.96220564
48	CSNK1G2	0.93120266
49	RPS6KA5	0.92324007
50	IKBKE	0.89892243
51	TNK2	0.89219930
52	PIK3CG	0.89095101
53	MAP3K4	0.89008140
54	BTK	0.88949887
55	FES	0.84791222
56	ADRBK1	0.84291141
57	TIE1	0.83075521
58	CAMKK2	0.81334092
59	OBSCN	0.73850120
60	CSNK1A1L	0.73762980
61	LYN	0.72215331
62	PIK3CA	0.70504491
63	LCK	0.70279707
64	MST4	0.69904748
65	DAPK3	0.68516249
66	PRKCE	0.66531929
67	RIPK4	0.66517105
68	MAP2K2	0.66142781
69	ILK	0.65329941
70	PRKCQ	0.64573232
71	MUSK	0.61122367
72	NLK	0.60172531
73	PHKG2	0.59354507
74	PHKG1	0.59354507
75	MATK	0.58923630
76	PIM1	0.58348541
77	IGF1R	0.57399697
78	MAP2K6	0.57006537
79	PRKACA	0.55815283
80	CDK3	0.55306495
81	NME2	0.54906527
82	MKNK1	0.53920518
83	CSNK1A1	0.50363529
84	DAPK1	0.50330486
85	RPS6KA6	0.48209452
86	PIM2	0.48158283
87	GRK7	0.48031123
88	PRKCA	0.47135863
89	TNIK	0.45516952
90	HCK	0.45463923
91	NEK2	0.44973795
92	MAP2K7	0.44115795
93	PLK4	0.43858158
94	ABL1	0.43596089
95	CAMK2A	0.43542211
96	CSNK2A1	0.43241609
97	CSNK2A2	0.41334261
98	PRKG1	0.36463707
99	PRKCG	0.35347020
100	JAK3	0.32375232

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.10384162
2	Asthma_Homo sapiens_hsa05310	3.77458825
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.60523987
4	Allograft rejection_Homo sapiens_hsa05330	3.22215199
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.94312135
6	Graft-versus-host disease_Homo sapiens_hsa05332	2.85699579
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.82236802
8	Type I diabetes mellitus_Homo sapiens_hsa04940	2.75115051
9	Parkinsons disease_Homo sapiens_hsa05012	2.74544603
10	Proteasome_Homo sapiens_hsa03050	2.45628379
11	Protein export_Homo sapiens_hsa03060	2.16492155
12	Primary immunodeficiency_Homo sapiens_hsa05340	2.13625859
13	Phototransduction_Homo sapiens_hsa04744	1.92525606
14	Alzheimers disease_Homo sapiens_hsa05010	1.90297159
15	RNA polymerase_Homo sapiens_hsa03020	1.87648397
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.84808289
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.84213089
18	Huntingtons disease_Homo sapiens_hsa05016	1.78288848
19	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.77706100
20	Caffeine metabolism_Homo sapiens_hsa00232	1.75140555
21	Antigen processing and presentation_Homo sapiens_hsa04612	1.66751458
22	Cardiac muscle contraction_Homo sapiens_hsa04260	1.65766414
23	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.61545946
24	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.54765604
25	Nitrogen metabolism_Homo sapiens_hsa00910	1.51687262
26	Rheumatoid arthritis_Homo sapiens_hsa05323	1.44953863
27	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.42383926
28	Homologous recombination_Homo sapiens_hsa03440	1.25874598
29	One carbon pool by folate_Homo sapiens_hsa00670	1.22235284
30	RNA degradation_Homo sapiens_hsa03018	1.19204984
31	Viral myocarditis_Homo sapiens_hsa05416	1.19011400
32	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.18803337
33	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.12326075
34	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.08458859
35	Ether lipid metabolism_Homo sapiens_hsa00565	1.06532444
36	Olfactory transduction_Homo sapiens_hsa04740	1.06382250
37	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.04776452
38	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.04551547
39	Tryptophan metabolism_Homo sapiens_hsa00380	1.01585236
40	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.00126580
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.99463542
42	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.98880839
43	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.98151352
44	Chemical carcinogenesis_Homo sapiens_hsa05204	0.86532272
45	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.84604142
46	Butanoate metabolism_Homo sapiens_hsa00650	0.81593623
47	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.78992278
48	Retinol metabolism_Homo sapiens_hsa00830	0.78701033
49	Pyrimidine metabolism_Homo sapiens_hsa00240	0.77659358
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.76413184
51	Regulation of autophagy_Homo sapiens_hsa04140	0.76076270
52	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.75144946
53	Nicotine addiction_Homo sapiens_hsa05033	0.74958577
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.74352779
55	Propanoate metabolism_Homo sapiens_hsa00640	0.74134284
56	Peroxisome_Homo sapiens_hsa04146	0.73106712
57	Purine metabolism_Homo sapiens_hsa00230	0.71383757
58	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.70102891
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.68263671
60	Basal transcription factors_Homo sapiens_hsa03022	0.67984837
61	Collecting duct acid secretion_Homo sapiens_hsa04966	0.67086638
62	Fanconi anemia pathway_Homo sapiens_hsa03460	0.66016704
63	Leishmaniasis_Homo sapiens_hsa05140	0.64145501
64	Fat digestion and absorption_Homo sapiens_hsa04975	0.64105942
65	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.61444173
66	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.61330755
67	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.60601115
68	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.58276785
69	Taste transduction_Homo sapiens_hsa04742	0.57399282
70	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.51237644
71	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.50669370
72	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.50528547
73	Metabolic pathways_Homo sapiens_hsa01100	0.48598958
74	Nucleotide excision repair_Homo sapiens_hsa03420	0.45101800
75	Morphine addiction_Homo sapiens_hsa05032	0.44534886
76	Salivary secretion_Homo sapiens_hsa04970	0.44143659
77	Sulfur metabolism_Homo sapiens_hsa00920	0.43492957
78	Sulfur relay system_Homo sapiens_hsa04122	0.42769628
79	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.41945578
80	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.41647887
81	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.41271074
82	Selenocompound metabolism_Homo sapiens_hsa00450	0.41269322
83	African trypanosomiasis_Homo sapiens_hsa05143	0.38315445
84	Serotonergic synapse_Homo sapiens_hsa04726	0.35346715
85	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.34679055
86	Mineral absorption_Homo sapiens_hsa04978	0.34086137
87	RNA transport_Homo sapiens_hsa03013	0.30880059
88	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.30641480
89	Circadian entrainment_Homo sapiens_hsa04713	0.28050522
90	beta-Alanine metabolism_Homo sapiens_hsa00410	0.27479562
91	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.27429549
92	Spliceosome_Homo sapiens_hsa03040	0.26071579
93	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.25689236
94	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.24416293
95	GABAergic synapse_Homo sapiens_hsa04727	0.23464867
96	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.22093606
97	Base excision repair_Homo sapiens_hsa03410	0.21436075
98	Malaria_Homo sapiens_hsa05144	0.21244904
99	Non-homologous end-joining_Homo sapiens_hsa03450	0.20473389
100	Herpes simplex infection_Homo sapiens_hsa05168	0.19453902

RPL5P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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