RPL5P31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of chronic inflammatory response (GO:0002676)5.59860086
2chaperone-mediated protein transport (GO:0072321)5.13601686
3water-soluble vitamin biosynthetic process (GO:0042364)4.83240051
4rRNA modification (GO:0000154)4.71177071
5rRNA methylation (GO:0031167)4.65015847
6establishment of protein localization to mitochondrial membrane (GO:0090151)4.43646736
7regulation of isotype switching to IgG isotypes (GO:0048302)4.21605911
8somatic diversification of immunoglobulins involved in immune response (GO:0002208)4.20845027
9isotype switching (GO:0045190)4.20845027
10somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)4.20845027
11cullin deneddylation (GO:0010388)3.92666679
12DNA double-strand break processing (GO:0000729)3.92267194
13ATP synthesis coupled proton transport (GO:0015986)3.86096829
14energy coupled proton transport, down electrochemical gradient (GO:0015985)3.86096829
15DNA deamination (GO:0045006)3.83536754
16mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.78415328
17mitochondrial respiratory chain complex I assembly (GO:0032981)3.78415328
18NADH dehydrogenase complex assembly (GO:0010257)3.78415328
19proteasome assembly (GO:0043248)3.76951414
20CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.70571199
21somatic hypermutation of immunoglobulin genes (GO:0016446)3.65087830
22somatic diversification of immune receptors via somatic mutation (GO:0002566)3.65087830
23regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.62538290
24regulation of mitotic spindle checkpoint (GO:1903504)3.62538290
25GTP biosynthetic process (GO:0006183)3.62173345
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.61835058
27protein deneddylation (GO:0000338)3.58920564
28protein complex biogenesis (GO:0070271)3.58475592
29regulation of immunoglobulin secretion (GO:0051023)3.54228532
30exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.52927886
31termination of RNA polymerase I transcription (GO:0006363)3.52039536
32kinetochore assembly (GO:0051382)3.50832073
33mitochondrial respiratory chain complex assembly (GO:0033108)3.49181859
34transcription elongation from RNA polymerase III promoter (GO:0006385)3.43016845
35termination of RNA polymerase III transcription (GO:0006386)3.43016845
36ribosome biogenesis (GO:0042254)3.42585460
37respiratory chain complex IV assembly (GO:0008535)3.41549415
38T-helper cell differentiation (GO:0042093)3.36138572
39CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.36138572
40transcription elongation from RNA polymerase I promoter (GO:0006362)3.35897341
41regulation of podosome assembly (GO:0071801)3.33395010
42kinetochore organization (GO:0051383)3.32850131
43nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.30307289
44negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.26630925
45ribosomal large subunit biogenesis (GO:0042273)3.25619381
46positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.25497536
47regulation of response to tumor cell (GO:0002834)3.25455951
48positive regulation of response to tumor cell (GO:0002836)3.25455951
49positive regulation of immune response to tumor cell (GO:0002839)3.25455951
50regulation of immune response to tumor cell (GO:0002837)3.25455951
51ribosome assembly (GO:0042255)3.23406277
52rRNA processing (GO:0006364)3.21433226
53alpha-beta T cell differentiation involved in immune response (GO:0002293)3.19678266
54alpha-beta T cell activation involved in immune response (GO:0002287)3.19678266
55T cell differentiation involved in immune response (GO:0002292)3.19678266
56UTP biosynthetic process (GO:0006228)3.17910689
57rRNA metabolic process (GO:0016072)3.17634748
58protein-cofactor linkage (GO:0018065)3.14657224
59behavioral response to nicotine (GO:0035095)3.14031195
60somatic recombination of immunoglobulin gene segments (GO:0016447)3.10054060
61somatic diversification of immunoglobulins (GO:0016445)3.08849281
62positive regulation of DNA recombination (GO:0045911)3.08195386
63cellular component biogenesis (GO:0044085)3.05839494
64positive regulation of B cell mediated immunity (GO:0002714)3.02674706
65positive regulation of immunoglobulin mediated immune response (GO:0002891)3.02674706
66negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.02541586
67regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.01692108
68ribonucleoprotein complex biogenesis (GO:0022613)3.01191843
69positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.00395495
70cytokine production involved in immune response (GO:0002367)3.00201986
71positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.99100634
72regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.99064991
73transcription initiation from RNA polymerase I promoter (GO:0006361)2.98806533
74preassembly of GPI anchor in ER membrane (GO:0016254)2.94917256
75DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.93784157
76signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.90602654
77signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.90602654
78signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.90602654
79protein targeting to mitochondrion (GO:0006626)2.89377526
80regulation of cellular amino acid metabolic process (GO:0006521)2.88715317
81chromatin remodeling at centromere (GO:0031055)2.88401531
82tRNA aminoacylation (GO:0043039)2.88242285
83amino acid activation (GO:0043038)2.88242285
84positive regulation of isotype switching (GO:0045830)2.88084577
85mitochondrial RNA metabolic process (GO:0000959)2.87999144
86intracellular protein transmembrane import (GO:0044743)2.87777570
87negative regulation of ligase activity (GO:0051352)2.87274161
88negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.87274161
89DNA catabolic process, exonucleolytic (GO:0000738)2.86732688
90signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.85784829
91intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.85784829
92transcription from RNA polymerase I promoter (GO:0006360)2.85100724
93spliceosomal snRNP assembly (GO:0000387)2.84779118
94cytochrome complex assembly (GO:0017004)2.83722223
95RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.83185514
96tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.83185514
97tRNA metabolic process (GO:0006399)2.82586772
98protein transmembrane transport (GO:0071806)2.77969375
99ncRNA metabolic process (GO:0034660)2.76631628
100pseudouridine synthesis (GO:0001522)2.76130252

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.30965191
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.63189090
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.53588125
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.79956330
5ZNF274_21170338_ChIP-Seq_K562_Hela3.36606811
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.10855875
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.09937163
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.97673586
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.79486741
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.76078132
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.71714713
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.69150464
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.51873077
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.48609027
15VDR_23849224_ChIP-Seq_CD4+_Human2.39917148
16VDR_22108803_ChIP-Seq_LS180_Human2.33103424
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.28343290
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.27032581
19FOXP3_21729870_ChIP-Seq_TREG_Human2.25770092
20TAF15_26573619_Chip-Seq_HEK293_Human2.25215202
21ELK1_19687146_ChIP-ChIP_HELA_Human2.21553850
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.20699320
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.20097836
24PCGF2_27294783_Chip-Seq_ESCs_Mouse2.06011395
25EWS_26573619_Chip-Seq_HEK293_Human2.06002525
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.88634678
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.86143052
28GBX2_23144817_ChIP-Seq_PC3_Human1.82388937
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77731623
30MYC_18940864_ChIP-ChIP_HL60_Human1.76414796
31DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.71154235
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.70804925
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67184373
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.65114216
35MYC_19079543_ChIP-ChIP_MESCs_Mouse1.63876837
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63574260
37TTF2_22483619_ChIP-Seq_HELA_Human1.58856740
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.58486062
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.58008696
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53441038
41TP53_22573176_ChIP-Seq_HFKS_Human1.51506987
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.46885779
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39760743
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38522615
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31871951
46GABP_19822575_ChIP-Seq_HepG2_Human1.29830069
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.28132483
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27436529
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27392105
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25687512
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25328070
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24988158
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24043679
54FUS_26573619_Chip-Seq_HEK293_Human1.22739498
55P300_19829295_ChIP-Seq_ESCs_Human1.20922774
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20673759
57DCP1A_22483619_ChIP-Seq_HELA_Human1.17929099
58ER_23166858_ChIP-Seq_MCF-7_Human1.14597730
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.14130325
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.14046158
61FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12969439
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12490272
63IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.10340178
64EZH2_22144423_ChIP-Seq_EOC_Human1.08640605
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06523161
66BCAT_22108803_ChIP-Seq_LS180_Human1.05797175
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05111873
68MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03678386
69ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03278495
70IGF1R_20145208_ChIP-Seq_DFB_Human1.02593533
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00688003
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99892034
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99578023
74ELK1_22589737_ChIP-Seq_MCF10A_Human0.97792389
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97026482
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95531215
77XRN2_22483619_ChIP-Seq_HELA_Human0.95180419
78EZH2_27294783_Chip-Seq_NPCs_Mouse0.92883866
79FOXA1_25329375_ChIP-Seq_VCAP_Human0.91982392
80FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91982392
81KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89755532
82NANOG_19829295_ChIP-Seq_ESCs_Human0.87241290
83SOX2_19829295_ChIP-Seq_ESCs_Human0.87241290
84TP63_19390658_ChIP-ChIP_HaCaT_Human0.86989635
85POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86700982
86GATA3_26560356_Chip-Seq_TH2_Human0.84337003
87PHF8_20622853_ChIP-Seq_HELA_Human0.82035412
88RBPJ_21746931_ChIP-Seq_IB4_Human0.80653272
89IRF8_21731497_ChIP-ChIP_J774_Mouse0.80416042
90PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.80087550
91ETV1_20927104_ChIP-Seq_GIST48_Human0.79910384
92IRF1_19129219_ChIP-ChIP_H3396_Human0.78933043
93TCF4_22108803_ChIP-Seq_LS180_Human0.78417233
94STAT6_21828071_ChIP-Seq_BEAS2B_Human0.77741007
95SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.76660648
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.75775164
97KLF5_20875108_ChIP-Seq_MESCs_Mouse0.75664907
98EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.75394107
99SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.74847282
100POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.74809241

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.33608795
2MP0008875_abnormal_xenobiotic_pharmacok3.80905484
3MP0001348_abnormal_lacrimal_gland3.41449002
4MP0002102_abnormal_ear_morphology2.97982338
5MP0001873_stomach_inflammation2.93391224
6MP0008058_abnormal_DNA_repair2.90873379
7MP0008872_abnormal_physiological_respon2.63113268
8MP0003941_abnormal_skin_development2.45010850
9MP0001188_hyperpigmentation2.21634262
10MP0003718_maternal_effect2.15012946
11MP0002138_abnormal_hepatobiliary_system2.08044303
12MP0001501_abnormal_sleep_pattern2.07944636
13MP0003693_abnormal_embryo_hatching2.04856692
14MP0001835_abnormal_antigen_presentation1.93810561
15MP0005310_abnormal_salivary_gland1.93284850
16MP0009333_abnormal_splenocyte_physiolog1.86360326
17MP0001984_abnormal_olfaction1.85682034
18MP0003786_premature_aging1.85369073
19MP0004957_abnormal_blastocyst_morpholog1.81665345
20MP0005645_abnormal_hypothalamus_physiol1.79068630
21MP0004215_abnormal_myocardial_fiber1.75762043
22MP0008007_abnormal_cellular_replicative1.73323354
23MP0004133_heterotaxia1.73103369
24MP0003567_abnormal_fetal_cardiomyocyte1.72426141
25MP0001968_abnormal_touch/_nociception1.71738685
26MP0010094_abnormal_chromosome_stability1.68260596
27MP0002736_abnormal_nociception_after1.66867956
28MP0005671_abnormal_response_to1.66733356
29MP0006072_abnormal_retinal_apoptosis1.60513860
30MP0000685_abnormal_immune_system1.58349543
31MP0005551_abnormal_eye_electrophysiolog1.53957947
32MP0006292_abnormal_olfactory_placode1.48837013
33MP0003077_abnormal_cell_cycle1.45971271
34MP0003763_abnormal_thymus_physiology1.39287402
35MP0001486_abnormal_startle_reflex1.34112098
36MP0003787_abnormal_imprinting1.33918056
37MP0001790_abnormal_immune_system1.33465090
38MP0005387_immune_system_phenotype1.33465090
39MP0004742_abnormal_vestibular_system1.31646833
40MP0004142_abnormal_muscle_tone1.31591222
41MP0002254_reproductive_system_inflammat1.31319386
42MP0001346_abnormal_lacrimal_gland1.29576677
43MP0004885_abnormal_endolymph1.28461731
44MP0004381_abnormal_hair_follicle1.23570163
45MP0002277_abnormal_respiratory_mucosa1.21492068
46MP0001800_abnormal_humoral_immune1.19856136
47MP0009745_abnormal_behavioral_response1.19708607
48MP0004145_abnormal_muscle_electrophysio1.13938252
49MP0001919_abnormal_reproductive_system1.13067031
50MP0008995_early_reproductive_senescence1.09153302
51MP0002272_abnormal_nervous_system1.08832639
52MP0009697_abnormal_copulation1.08377883
53MP0006082_CNS_inflammation1.08309154
54MP0002163_abnormal_gland_morphology1.07763127
55MP0005253_abnormal_eye_physiology1.06647696
56MP0001485_abnormal_pinna_reflex1.05619153
57MP0003646_muscle_fatigue1.05105683
58MP0005084_abnormal_gallbladder_morpholo1.02633372
59MP0005389_reproductive_system_phenotype1.02268544
60MP0006036_abnormal_mitochondrial_physio1.01962579
61MP0002653_abnormal_ependyma_morphology1.00109396
62MP0003111_abnormal_nucleus_morphology0.98278924
63MP0003011_delayed_dark_adaptation0.98124937
64MP0002166_altered_tumor_susceptibility0.97500948
65MP0008789_abnormal_olfactory_epithelium0.95203228
66MP0002148_abnormal_hypersensitivity_rea0.93937673
67MP0003136_yellow_coat_color0.83960489
68MP0004782_abnormal_surfactant_physiolog0.83159212
69MP0004084_abnormal_cardiac_muscle0.82881851
70MP0008932_abnormal_embryonic_tissue0.82393444
71MP0002006_tumorigenesis0.79871809
72MP0001529_abnormal_vocalization0.79584787
73MP0009785_altered_susceptibility_to0.79412162
74MP0003186_abnormal_redox_activity0.79049214
75MP0001905_abnormal_dopamine_level0.76528470
76MP0002210_abnormal_sex_determination0.76345315
77MP0000631_abnormal_neuroendocrine_gland0.73984112
78MP0005410_abnormal_fertilization0.73754240
79MP0009379_abnormal_foot_pigmentation0.73398246
80MP0001963_abnormal_hearing_physiology0.73173013
81MP0003806_abnormal_nucleotide_metabolis0.71827973
82MP0002693_abnormal_pancreas_physiology0.71558199
83MP0002229_neurodegeneration0.71279669
84MP0001929_abnormal_gametogenesis0.70933737
85MP0002184_abnormal_innervation0.70898647
86MP0001764_abnormal_homeostasis0.70644445
87MP0001293_anophthalmia0.70636591
88MP0005075_abnormal_melanosome_morpholog0.69491031
89MP0002405_respiratory_system_inflammati0.69257293
90MP0002837_dystrophic_cardiac_calcinosis0.68766328
91MP0000703_abnormal_thymus_morphology0.68080673
92MP0000026_abnormal_inner_ear0.66550485
93MP0005000_abnormal_immune_tolerance0.65382947
94MP0001970_abnormal_pain_threshold0.64822721
95MP0005394_taste/olfaction_phenotype0.64679043
96MP0005499_abnormal_olfactory_system0.64679043
97MP0000653_abnormal_sex_gland0.64385197
98MP0001986_abnormal_taste_sensitivity0.64281797
99MP0003195_calcinosis0.64274662
100MP0005377_hearing/vestibular/ear_phenot0.62889790

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.57600161
2Stomatitis (HP:0010280)4.04806778
3Progressive macrocephaly (HP:0004481)4.03743579
4Acute encephalopathy (HP:0006846)3.93155414
5Abnormal mitochondria in muscle tissue (HP:0008316)3.84792233
6Increased CSF lactate (HP:0002490)3.78100030
7Colon cancer (HP:0003003)3.61099306
8Mitochondrial inheritance (HP:0001427)3.54407010
9Hypoplasia of the pons (HP:0012110)3.16430169
10Abnormality of the pons (HP:0007361)3.10999308
11Hepatocellular necrosis (HP:0001404)3.07406795
12Congenital stationary night blindness (HP:0007642)3.05312028
13Increased hepatocellular lipid droplets (HP:0006565)3.00743848
14Cerebral edema (HP:0002181)2.89950959
15Methylmalonic aciduria (HP:0012120)2.88555257
16Methylmalonic acidemia (HP:0002912)2.86851202
17Abnormality of the labia minora (HP:0012880)2.84843536
18IgG deficiency (HP:0004315)2.83269383
19Lipid accumulation in hepatocytes (HP:0006561)2.76159750
20Optic disc pallor (HP:0000543)2.75536252
213-Methylglutaconic aciduria (HP:0003535)2.67631080
22Nephronophthisis (HP:0000090)2.60747343
23Hepatic necrosis (HP:0002605)2.59648305
24Pendular nystagmus (HP:0012043)2.55311038
25Multiple enchondromatosis (HP:0005701)2.52958207
26IgA deficiency (HP:0002720)2.51142060
27Increased serum lactate (HP:0002151)2.45658060
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.38558381
29Birth length less than 3rd percentile (HP:0003561)2.36838634
30Abnormality of midbrain morphology (HP:0002418)2.35016904
31Molar tooth sign on MRI (HP:0002419)2.35016904
32Congenital, generalized hypertrichosis (HP:0004540)2.32516141
33Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.31420576
34Hypomagnesemia (HP:0002917)2.25641226
35Ependymoma (HP:0002888)2.23600671
36Reticulocytopenia (HP:0001896)2.23360915
37Retrobulbar optic neuritis (HP:0100654)2.21580793
38Optic neuritis (HP:0100653)2.21580793
39Medial flaring of the eyebrow (HP:0010747)2.16364748
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.16317825
41Abnormality of alanine metabolism (HP:0010916)2.16317825
42Hyperalaninemia (HP:0003348)2.16317825
43Biliary tract neoplasm (HP:0100574)2.15003998
44Leukodystrophy (HP:0002415)2.14425344
45Degeneration of the lateral corticospinal tracts (HP:0002314)2.14322380
46Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.14322380
47Hypoplasia of the radius (HP:0002984)2.13942524
48Abnormality of the renal medulla (HP:0100957)2.11839758
49Increased IgM level (HP:0003496)2.10312451
50Optic nerve hypoplasia (HP:0000609)2.08627586
51B lymphocytopenia (HP:0010976)2.04206233
52Abnormality of magnesium homeostasis (HP:0004921)2.02059059
53Renal Fanconi syndrome (HP:0001994)2.01906976
54Central scotoma (HP:0000603)2.00215923
55Abnormality of the renal cortex (HP:0011035)1.99236260
56Exercise intolerance (HP:0003546)1.97209569
57Lethargy (HP:0001254)1.93146344
58Respiratory difficulties (HP:0002880)1.92712727
59Lactic acidosis (HP:0003128)1.91940116
60Abnormality of B cell number (HP:0010975)1.91549351
61Pancreatic cysts (HP:0001737)1.89386511
62Aplastic anemia (HP:0001915)1.88990593
63Abolished electroretinogram (ERG) (HP:0000550)1.88714341
64Septo-optic dysplasia (HP:0100842)1.86361287
65Bile duct proliferation (HP:0001408)1.84411948
66Abnormal biliary tract physiology (HP:0012439)1.84411948
67Forearm undergrowth (HP:0009821)1.83850929
68Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.83585421
69IgM deficiency (HP:0002850)1.82738865
70Inability to walk (HP:0002540)1.82272159
71Supernumerary spleens (HP:0009799)1.80743466
72Aplasia/Hypoplasia of the spleen (HP:0010451)1.80034417
73Hypoplasia of the ulna (HP:0003022)1.79432732
74Meckel diverticulum (HP:0002245)1.76028233
75Carpal bone hypoplasia (HP:0001498)1.75703064
76Aplasia/Hypoplasia of the ulna (HP:0006495)1.74911264
77Tetany (HP:0001281)1.74025673
78Exertional dyspnea (HP:0002875)1.73636007
79Abnormality of the vitamin B12 metabolism (HP:0004341)1.72707589
80Rhabdomyosarcoma (HP:0002859)1.72123271
81Respiratory failure (HP:0002878)1.71402553
82Asplenia (HP:0001746)1.68773756
83Conjunctival hamartoma (HP:0100780)1.68433908
84Cleft eyelid (HP:0000625)1.68254168
85Growth hormone deficiency (HP:0000824)1.67496455
86Volvulus (HP:0002580)1.67003010
87Abnormal spermatogenesis (HP:0008669)1.66825627
88Abnormality of chromosome stability (HP:0003220)1.65819600
89Chromsome breakage (HP:0040012)1.65225232
90Oligodactyly (hands) (HP:0001180)1.65004955
91Horseshoe kidney (HP:0000085)1.64944103
92Ectopic kidney (HP:0000086)1.64585989
93Abnormality of T cells (HP:0002843)1.63797110
94Neutropenia (HP:0001875)1.63179414
95Hypoproteinemia (HP:0003075)1.63094373
96Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.62687375
97Breast carcinoma (HP:0003002)1.62396612
98Tubular atrophy (HP:0000092)1.62349787
99Abnormality of the ileum (HP:0001549)1.61874584
100Type II lissencephaly (HP:0007260)1.61787893

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK4.34365340
2TSSK63.74588840
3STK163.69655513
4NME13.61174322
5NUAK13.26035793
6TNIK2.93685773
7BUB12.92946024
8MST42.68286319
9PINK12.57692506
10TAOK12.53804675
11WNK32.47331567
12WNK42.45349359
13TXK2.27771101
14ADRBK22.19577600
15SRPK12.14022005
16ZAK2.13507942
17MAP2K62.04695751
18GRK11.81890643
19MKNK21.79370825
20MAP4K11.79183349
21NLK1.67930003
22EIF2AK11.54302860
23NEK11.51844705
24ALK1.45242784
25EIF2AK31.44918903
26PASK1.41645811
27MKNK11.38506164
28TLK11.38398206
29PLK31.36461884
30TAOK31.33675418
31TRIM281.28074276
32STK391.27676470
33OXSR11.25139696
34CDC71.22914127
35FRK1.18364130
36VRK21.12534801
37DYRK21.12450652
38TAF11.07335073
39CASK1.00871136
40PRKG20.96478634
41WEE10.96024106
42BMPR1B0.95880836
43TTK0.93892142
44VRK10.93118387
45BCKDK0.91166179
46PDK20.88613269
47EIF2AK20.82583508
48TGFBR10.81764349
49DMPK0.81183117
50PLK10.71608637
51ITK0.66028774
52NME20.64189306
53MAPKAPK30.62289237
54PIK3CA0.59793958
55PRKCG0.57481512
56PRKCQ0.57013570
57PHKG10.54795450
58PHKG20.54795450
59TIE10.52001470
60PLK40.49560402
61CSNK1E0.48623266
62CAMK2A0.46987078
63TAOK20.45515063
64AURKB0.44078953
65CDK30.43867561
66MAP3K40.43236586
67WNK10.41885037
68LCK0.40778648
69STK40.40049884
70PRKG10.37774286
71FGFR10.36822894
72TYRO30.36685134
73INSRR0.36659067
74CSNK2A20.36332471
75CDK70.35552360
76TEC0.34488250
77ATR0.31518322
78CAMK10.29699703
79RPS6KA50.29435735
80CLK10.28513485
81ZAP700.28025249
82MAP4K20.27776527
83MAP3K110.27414038
84SYK0.27311518
85STK38L0.27291993
86BCR0.25668297
87PIK3CG0.25664997
88FES0.25637021
89IRAK30.25342941
90NEK20.25009653
91PKN10.24567813
92MAP2K20.23669024
93PIM10.23344025
94CSNK2A10.22726266
95MINK10.22274798
96MATK0.20902218
97CDK190.20679389
98DYRK1B0.20608260
99STK110.19217574
100ATM0.19027673

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.07111864
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.29793019
3RNA polymerase_Homo sapiens_hsa030203.00582698
4Ribosome_Homo sapiens_hsa030102.97445194
5Asthma_Homo sapiens_hsa053102.84778790
6Protein export_Homo sapiens_hsa030602.84566242
7Mismatch repair_Homo sapiens_hsa034302.62293042
8Oxidative phosphorylation_Homo sapiens_hsa001902.59800976
9Basal transcription factors_Homo sapiens_hsa030222.45252374
10Homologous recombination_Homo sapiens_hsa034402.42806484
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.28848879
12Parkinsons disease_Homo sapiens_hsa050122.28261735
13Allograft rejection_Homo sapiens_hsa053302.26370716
14RNA degradation_Homo sapiens_hsa030182.09756488
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.09754335
16One carbon pool by folate_Homo sapiens_hsa006702.09049095
17Autoimmune thyroid disease_Homo sapiens_hsa053202.05194702
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.04584827
19Nucleotide excision repair_Homo sapiens_hsa034201.94606358
20RNA transport_Homo sapiens_hsa030131.78942258
21DNA replication_Homo sapiens_hsa030301.76880275
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.75911391
23Huntingtons disease_Homo sapiens_hsa050161.57994302
24Vitamin B6 metabolism_Homo sapiens_hsa007501.56462948
25Primary immunodeficiency_Homo sapiens_hsa053401.54310973
26Propanoate metabolism_Homo sapiens_hsa006401.53246682
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.44353047
28Spliceosome_Homo sapiens_hsa030401.37733607
29Linoleic acid metabolism_Homo sapiens_hsa005911.37040213
30Pyrimidine metabolism_Homo sapiens_hsa002401.32686956
31Non-homologous end-joining_Homo sapiens_hsa034501.30817828
32Phototransduction_Homo sapiens_hsa047441.26872983
33Fanconi anemia pathway_Homo sapiens_hsa034601.24471308
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23543558
35Alzheimers disease_Homo sapiens_hsa050101.21798474
36Purine metabolism_Homo sapiens_hsa002301.16429470
37Nicotine addiction_Homo sapiens_hsa050331.15798821
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.13638683
39Cardiac muscle contraction_Homo sapiens_hsa042601.09868098
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06958161
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04218527
42Base excision repair_Homo sapiens_hsa034101.02467760
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.98446774
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96068261
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94168879
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92701513
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92642740
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86852588
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86765442
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86735452
51Caffeine metabolism_Homo sapiens_hsa002320.86735313
52Selenocompound metabolism_Homo sapiens_hsa004500.85158769
53Ether lipid metabolism_Homo sapiens_hsa005650.84505833
54Type I diabetes mellitus_Homo sapiens_hsa049400.79596225
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78974524
56Pyruvate metabolism_Homo sapiens_hsa006200.77736844
57Hematopoietic cell lineage_Homo sapiens_hsa046400.71406863
58Morphine addiction_Homo sapiens_hsa050320.68422653
59Peroxisome_Homo sapiens_hsa041460.67847870
60T cell receptor signaling pathway_Homo sapiens_hsa046600.61965008
61Cell cycle_Homo sapiens_hsa041100.59119207
62GABAergic synapse_Homo sapiens_hsa047270.58502846
63Metabolic pathways_Homo sapiens_hsa011000.57423763
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.57312865
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56997681
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.54622741
67Fatty acid biosynthesis_Homo sapiens_hsa000610.52517548
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51568967
69Chemical carcinogenesis_Homo sapiens_hsa052040.50933404
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50473983
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50319254
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48819597
73Vitamin digestion and absorption_Homo sapiens_hsa049770.47435189
74Tryptophan metabolism_Homo sapiens_hsa003800.47385426
75Olfactory transduction_Homo sapiens_hsa047400.46488626
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.46331326
77mRNA surveillance pathway_Homo sapiens_hsa030150.45808537
78Epstein-Barr virus infection_Homo sapiens_hsa051690.45103209
79Taste transduction_Homo sapiens_hsa047420.44823569
80Arachidonic acid metabolism_Homo sapiens_hsa005900.44739000
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.42657060
82Ovarian steroidogenesis_Homo sapiens_hsa049130.40022482
83Butanoate metabolism_Homo sapiens_hsa006500.37889711
84Retinol metabolism_Homo sapiens_hsa008300.36413785
85Serotonergic synapse_Homo sapiens_hsa047260.35105533
86Salivary secretion_Homo sapiens_hsa049700.34717802
87Sulfur metabolism_Homo sapiens_hsa009200.34503145
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30497416
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30109843
90Fat digestion and absorption_Homo sapiens_hsa049750.28538920
91Glutathione metabolism_Homo sapiens_hsa004800.28121604
92Collecting duct acid secretion_Homo sapiens_hsa049660.28043633
93Circadian entrainment_Homo sapiens_hsa047130.27224304
94Nitrogen metabolism_Homo sapiens_hsa009100.26617333
95Glutamatergic synapse_Homo sapiens_hsa047240.25415375
96Oocyte meiosis_Homo sapiens_hsa041140.23784126
97Graft-versus-host disease_Homo sapiens_hsa053320.22664894
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22140865
99Circadian rhythm_Homo sapiens_hsa047100.21853908
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21004382

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