

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of chronic inflammatory response (GO:0002676) | 5.59860086 |
| 2 | chaperone-mediated protein transport (GO:0072321) | 5.13601686 |
| 3 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.83240051 |
| 4 | rRNA modification (GO:0000154) | 4.71177071 |
| 5 | rRNA methylation (GO:0031167) | 4.65015847 |
| 6 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.43646736 |
| 7 | regulation of isotype switching to IgG isotypes (GO:0048302) | 4.21605911 |
| 8 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 4.20845027 |
| 9 | isotype switching (GO:0045190) | 4.20845027 |
| 10 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 4.20845027 |
| 11 | cullin deneddylation (GO:0010388) | 3.92666679 |
| 12 | DNA double-strand break processing (GO:0000729) | 3.92267194 |
| 13 | ATP synthesis coupled proton transport (GO:0015986) | 3.86096829 |
| 14 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.86096829 |
| 15 | DNA deamination (GO:0045006) | 3.83536754 |
| 16 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.78415328 |
| 17 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.78415328 |
| 18 | NADH dehydrogenase complex assembly (GO:0010257) | 3.78415328 |
| 19 | proteasome assembly (GO:0043248) | 3.76951414 |
| 20 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369) | 3.70571199 |
| 21 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.65087830 |
| 22 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.65087830 |
| 23 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.62538290 |
| 24 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.62538290 |
| 25 | GTP biosynthetic process (GO:0006183) | 3.62173345 |
| 26 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.61835058 |
| 27 | protein deneddylation (GO:0000338) | 3.58920564 |
| 28 | protein complex biogenesis (GO:0070271) | 3.58475592 |
| 29 | regulation of immunoglobulin secretion (GO:0051023) | 3.54228532 |
| 30 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.52927886 |
| 31 | termination of RNA polymerase I transcription (GO:0006363) | 3.52039536 |
| 32 | kinetochore assembly (GO:0051382) | 3.50832073 |
| 33 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.49181859 |
| 34 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.43016845 |
| 35 | termination of RNA polymerase III transcription (GO:0006386) | 3.43016845 |
| 36 | ribosome biogenesis (GO:0042254) | 3.42585460 |
| 37 | respiratory chain complex IV assembly (GO:0008535) | 3.41549415 |
| 38 | T-helper cell differentiation (GO:0042093) | 3.36138572 |
| 39 | CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294) | 3.36138572 |
| 40 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.35897341 |
| 41 | regulation of podosome assembly (GO:0071801) | 3.33395010 |
| 42 | kinetochore organization (GO:0051383) | 3.32850131 |
| 43 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.30307289 |
| 44 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.26630925 |
| 45 | ribosomal large subunit biogenesis (GO:0042273) | 3.25619381 |
| 46 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 3.25497536 |
| 47 | regulation of response to tumor cell (GO:0002834) | 3.25455951 |
| 48 | positive regulation of response to tumor cell (GO:0002836) | 3.25455951 |
| 49 | positive regulation of immune response to tumor cell (GO:0002839) | 3.25455951 |
| 50 | regulation of immune response to tumor cell (GO:0002837) | 3.25455951 |
| 51 | ribosome assembly (GO:0042255) | 3.23406277 |
| 52 | rRNA processing (GO:0006364) | 3.21433226 |
| 53 | alpha-beta T cell differentiation involved in immune response (GO:0002293) | 3.19678266 |
| 54 | alpha-beta T cell activation involved in immune response (GO:0002287) | 3.19678266 |
| 55 | T cell differentiation involved in immune response (GO:0002292) | 3.19678266 |
| 56 | UTP biosynthetic process (GO:0006228) | 3.17910689 |
| 57 | rRNA metabolic process (GO:0016072) | 3.17634748 |
| 58 | protein-cofactor linkage (GO:0018065) | 3.14657224 |
| 59 | behavioral response to nicotine (GO:0035095) | 3.14031195 |
| 60 | somatic recombination of immunoglobulin gene segments (GO:0016447) | 3.10054060 |
| 61 | somatic diversification of immunoglobulins (GO:0016445) | 3.08849281 |
| 62 | positive regulation of DNA recombination (GO:0045911) | 3.08195386 |
| 63 | cellular component biogenesis (GO:0044085) | 3.05839494 |
| 64 | positive regulation of B cell mediated immunity (GO:0002714) | 3.02674706 |
| 65 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 3.02674706 |
| 66 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 3.02541586 |
| 67 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.01692108 |
| 68 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.01191843 |
| 69 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.00395495 |
| 70 | cytokine production involved in immune response (GO:0002367) | 3.00201986 |
| 71 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 2.99100634 |
| 72 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 2.99064991 |
| 73 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 2.98806533 |
| 74 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.94917256 |
| 75 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.93784157 |
| 76 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.90602654 |
| 77 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.90602654 |
| 78 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.90602654 |
| 79 | protein targeting to mitochondrion (GO:0006626) | 2.89377526 |
| 80 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.88715317 |
| 81 | chromatin remodeling at centromere (GO:0031055) | 2.88401531 |
| 82 | tRNA aminoacylation (GO:0043039) | 2.88242285 |
| 83 | amino acid activation (GO:0043038) | 2.88242285 |
| 84 | positive regulation of isotype switching (GO:0045830) | 2.88084577 |
| 85 | mitochondrial RNA metabolic process (GO:0000959) | 2.87999144 |
| 86 | intracellular protein transmembrane import (GO:0044743) | 2.87777570 |
| 87 | negative regulation of ligase activity (GO:0051352) | 2.87274161 |
| 88 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.87274161 |
| 89 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.86732688 |
| 90 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.85784829 |
| 91 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.85784829 |
| 92 | transcription from RNA polymerase I promoter (GO:0006360) | 2.85100724 |
| 93 | spliceosomal snRNP assembly (GO:0000387) | 2.84779118 |
| 94 | cytochrome complex assembly (GO:0017004) | 2.83722223 |
| 95 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.83185514 |
| 96 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.83185514 |
| 97 | tRNA metabolic process (GO:0006399) | 2.82586772 |
| 98 | protein transmembrane transport (GO:0071806) | 2.77969375 |
| 99 | ncRNA metabolic process (GO:0034660) | 2.76631628 |
| 100 | pseudouridine synthesis (GO:0001522) | 2.76130252 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 5.30965191 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.63189090 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.53588125 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.79956330 |
| 5 | ZNF274_21170338_ChIP-Seq_K562_Hela | 3.36606811 |
| 6 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.10855875 |
| 7 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.09937163 |
| 8 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.97673586 |
| 9 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.79486741 |
| 10 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.76078132 |
| 11 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.71714713 |
| 12 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.69150464 |
| 13 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.51873077 |
| 14 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.48609027 |
| 15 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.39917148 |
| 16 | VDR_22108803_ChIP-Seq_LS180_Human | 2.33103424 |
| 17 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.28343290 |
| 18 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.27032581 |
| 19 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.25770092 |
| 20 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.25215202 |
| 21 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.21553850 |
| 22 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.20699320 |
| 23 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.20097836 |
| 24 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 2.06011395 |
| 25 | EWS_26573619_Chip-Seq_HEK293_Human | 2.06002525 |
| 26 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.88634678 |
| 27 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.86143052 |
| 28 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.82388937 |
| 29 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.77731623 |
| 30 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.76414796 |
| 31 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.71154235 |
| 32 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.70804925 |
| 33 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.67184373 |
| 34 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.65114216 |
| 35 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.63876837 |
| 36 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.63574260 |
| 37 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.58856740 |
| 38 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.58486062 |
| 39 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.58008696 |
| 40 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.53441038 |
| 41 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.51506987 |
| 42 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.46885779 |
| 43 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.39760743 |
| 44 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.38522615 |
| 45 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.31871951 |
| 46 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.29830069 |
| 47 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.28132483 |
| 48 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.27436529 |
| 49 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.27392105 |
| 50 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.25687512 |
| 51 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.25328070 |
| 52 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.24988158 |
| 53 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.24043679 |
| 54 | FUS_26573619_Chip-Seq_HEK293_Human | 1.22739498 |
| 55 | P300_19829295_ChIP-Seq_ESCs_Human | 1.20922774 |
| 56 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.20673759 |
| 57 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.17929099 |
| 58 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.14597730 |
| 59 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.14130325 |
| 60 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.14046158 |
| 61 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.12969439 |
| 62 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.12490272 |
| 63 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.10340178 |
| 64 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.08640605 |
| 65 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.06523161 |
| 66 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.05797175 |
| 67 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.05111873 |
| 68 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.03678386 |
| 69 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.03278495 |
| 70 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.02593533 |
| 71 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.00688003 |
| 72 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.99892034 |
| 73 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.99578023 |
| 74 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.97792389 |
| 75 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.97026482 |
| 76 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.95531215 |
| 77 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.95180419 |
| 78 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.92883866 |
| 79 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.91982392 |
| 80 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.91982392 |
| 81 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.89755532 |
| 82 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.87241290 |
| 83 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.87241290 |
| 84 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.86989635 |
| 85 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.86700982 |
| 86 | GATA3_26560356_Chip-Seq_TH2_Human | 0.84337003 |
| 87 | PHF8_20622853_ChIP-Seq_HELA_Human | 0.82035412 |
| 88 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.80653272 |
| 89 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 0.80416042 |
| 90 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.80087550 |
| 91 | ETV1_20927104_ChIP-Seq_GIST48_Human | 0.79910384 |
| 92 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.78933043 |
| 93 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.78417233 |
| 94 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 0.77741007 |
| 95 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.76660648 |
| 96 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.75775164 |
| 97 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.75664907 |
| 98 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 0.75394107 |
| 99 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.74847282 |
| 100 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.74809241 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008877_abnormal_DNA_methylation | 4.33608795 |
| 2 | MP0008875_abnormal_xenobiotic_pharmacok | 3.80905484 |
| 3 | MP0001348_abnormal_lacrimal_gland | 3.41449002 |
| 4 | MP0002102_abnormal_ear_morphology | 2.97982338 |
| 5 | MP0001873_stomach_inflammation | 2.93391224 |
| 6 | MP0008058_abnormal_DNA_repair | 2.90873379 |
| 7 | MP0008872_abnormal_physiological_respon | 2.63113268 |
| 8 | MP0003941_abnormal_skin_development | 2.45010850 |
| 9 | MP0001188_hyperpigmentation | 2.21634262 |
| 10 | MP0003718_maternal_effect | 2.15012946 |
| 11 | MP0002138_abnormal_hepatobiliary_system | 2.08044303 |
| 12 | MP0001501_abnormal_sleep_pattern | 2.07944636 |
| 13 | MP0003693_abnormal_embryo_hatching | 2.04856692 |
| 14 | MP0001835_abnormal_antigen_presentation | 1.93810561 |
| 15 | MP0005310_abnormal_salivary_gland | 1.93284850 |
| 16 | MP0009333_abnormal_splenocyte_physiolog | 1.86360326 |
| 17 | MP0001984_abnormal_olfaction | 1.85682034 |
| 18 | MP0003786_premature_aging | 1.85369073 |
| 19 | MP0004957_abnormal_blastocyst_morpholog | 1.81665345 |
| 20 | MP0005645_abnormal_hypothalamus_physiol | 1.79068630 |
| 21 | MP0004215_abnormal_myocardial_fiber | 1.75762043 |
| 22 | MP0008007_abnormal_cellular_replicative | 1.73323354 |
| 23 | MP0004133_heterotaxia | 1.73103369 |
| 24 | MP0003567_abnormal_fetal_cardiomyocyte | 1.72426141 |
| 25 | MP0001968_abnormal_touch/_nociception | 1.71738685 |
| 26 | MP0010094_abnormal_chromosome_stability | 1.68260596 |
| 27 | MP0002736_abnormal_nociception_after | 1.66867956 |
| 28 | MP0005671_abnormal_response_to | 1.66733356 |
| 29 | MP0006072_abnormal_retinal_apoptosis | 1.60513860 |
| 30 | MP0000685_abnormal_immune_system | 1.58349543 |
| 31 | MP0005551_abnormal_eye_electrophysiolog | 1.53957947 |
| 32 | MP0006292_abnormal_olfactory_placode | 1.48837013 |
| 33 | MP0003077_abnormal_cell_cycle | 1.45971271 |
| 34 | MP0003763_abnormal_thymus_physiology | 1.39287402 |
| 35 | MP0001486_abnormal_startle_reflex | 1.34112098 |
| 36 | MP0003787_abnormal_imprinting | 1.33918056 |
| 37 | MP0001790_abnormal_immune_system | 1.33465090 |
| 38 | MP0005387_immune_system_phenotype | 1.33465090 |
| 39 | MP0004742_abnormal_vestibular_system | 1.31646833 |
| 40 | MP0004142_abnormal_muscle_tone | 1.31591222 |
| 41 | MP0002254_reproductive_system_inflammat | 1.31319386 |
| 42 | MP0001346_abnormal_lacrimal_gland | 1.29576677 |
| 43 | MP0004885_abnormal_endolymph | 1.28461731 |
| 44 | MP0004381_abnormal_hair_follicle | 1.23570163 |
| 45 | MP0002277_abnormal_respiratory_mucosa | 1.21492068 |
| 46 | MP0001800_abnormal_humoral_immune | 1.19856136 |
| 47 | MP0009745_abnormal_behavioral_response | 1.19708607 |
| 48 | MP0004145_abnormal_muscle_electrophysio | 1.13938252 |
| 49 | MP0001919_abnormal_reproductive_system | 1.13067031 |
| 50 | MP0008995_early_reproductive_senescence | 1.09153302 |
| 51 | MP0002272_abnormal_nervous_system | 1.08832639 |
| 52 | MP0009697_abnormal_copulation | 1.08377883 |
| 53 | MP0006082_CNS_inflammation | 1.08309154 |
| 54 | MP0002163_abnormal_gland_morphology | 1.07763127 |
| 55 | MP0005253_abnormal_eye_physiology | 1.06647696 |
| 56 | MP0001485_abnormal_pinna_reflex | 1.05619153 |
| 57 | MP0003646_muscle_fatigue | 1.05105683 |
| 58 | MP0005084_abnormal_gallbladder_morpholo | 1.02633372 |
| 59 | MP0005389_reproductive_system_phenotype | 1.02268544 |
| 60 | MP0006036_abnormal_mitochondrial_physio | 1.01962579 |
| 61 | MP0002653_abnormal_ependyma_morphology | 1.00109396 |
| 62 | MP0003111_abnormal_nucleus_morphology | 0.98278924 |
| 63 | MP0003011_delayed_dark_adaptation | 0.98124937 |
| 64 | MP0002166_altered_tumor_susceptibility | 0.97500948 |
| 65 | MP0008789_abnormal_olfactory_epithelium | 0.95203228 |
| 66 | MP0002148_abnormal_hypersensitivity_rea | 0.93937673 |
| 67 | MP0003136_yellow_coat_color | 0.83960489 |
| 68 | MP0004782_abnormal_surfactant_physiolog | 0.83159212 |
| 69 | MP0004084_abnormal_cardiac_muscle | 0.82881851 |
| 70 | MP0008932_abnormal_embryonic_tissue | 0.82393444 |
| 71 | MP0002006_tumorigenesis | 0.79871809 |
| 72 | MP0001529_abnormal_vocalization | 0.79584787 |
| 73 | MP0009785_altered_susceptibility_to | 0.79412162 |
| 74 | MP0003186_abnormal_redox_activity | 0.79049214 |
| 75 | MP0001905_abnormal_dopamine_level | 0.76528470 |
| 76 | MP0002210_abnormal_sex_determination | 0.76345315 |
| 77 | MP0000631_abnormal_neuroendocrine_gland | 0.73984112 |
| 78 | MP0005410_abnormal_fertilization | 0.73754240 |
| 79 | MP0009379_abnormal_foot_pigmentation | 0.73398246 |
| 80 | MP0001963_abnormal_hearing_physiology | 0.73173013 |
| 81 | MP0003806_abnormal_nucleotide_metabolis | 0.71827973 |
| 82 | MP0002693_abnormal_pancreas_physiology | 0.71558199 |
| 83 | MP0002229_neurodegeneration | 0.71279669 |
| 84 | MP0001929_abnormal_gametogenesis | 0.70933737 |
| 85 | MP0002184_abnormal_innervation | 0.70898647 |
| 86 | MP0001764_abnormal_homeostasis | 0.70644445 |
| 87 | MP0001293_anophthalmia | 0.70636591 |
| 88 | MP0005075_abnormal_melanosome_morpholog | 0.69491031 |
| 89 | MP0002405_respiratory_system_inflammati | 0.69257293 |
| 90 | MP0002837_dystrophic_cardiac_calcinosis | 0.68766328 |
| 91 | MP0000703_abnormal_thymus_morphology | 0.68080673 |
| 92 | MP0000026_abnormal_inner_ear | 0.66550485 |
| 93 | MP0005000_abnormal_immune_tolerance | 0.65382947 |
| 94 | MP0001970_abnormal_pain_threshold | 0.64822721 |
| 95 | MP0005394_taste/olfaction_phenotype | 0.64679043 |
| 96 | MP0005499_abnormal_olfactory_system | 0.64679043 |
| 97 | MP0000653_abnormal_sex_gland | 0.64385197 |
| 98 | MP0001986_abnormal_taste_sensitivity | 0.64281797 |
| 99 | MP0003195_calcinosis | 0.64274662 |
| 100 | MP0005377_hearing/vestibular/ear_phenot | 0.62889790 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.57600161 |
| 2 | Stomatitis (HP:0010280) | 4.04806778 |
| 3 | Progressive macrocephaly (HP:0004481) | 4.03743579 |
| 4 | Acute encephalopathy (HP:0006846) | 3.93155414 |
| 5 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.84792233 |
| 6 | Increased CSF lactate (HP:0002490) | 3.78100030 |
| 7 | Colon cancer (HP:0003003) | 3.61099306 |
| 8 | Mitochondrial inheritance (HP:0001427) | 3.54407010 |
| 9 | Hypoplasia of the pons (HP:0012110) | 3.16430169 |
| 10 | Abnormality of the pons (HP:0007361) | 3.10999308 |
| 11 | Hepatocellular necrosis (HP:0001404) | 3.07406795 |
| 12 | Congenital stationary night blindness (HP:0007642) | 3.05312028 |
| 13 | Increased hepatocellular lipid droplets (HP:0006565) | 3.00743848 |
| 14 | Cerebral edema (HP:0002181) | 2.89950959 |
| 15 | Methylmalonic aciduria (HP:0012120) | 2.88555257 |
| 16 | Methylmalonic acidemia (HP:0002912) | 2.86851202 |
| 17 | Abnormality of the labia minora (HP:0012880) | 2.84843536 |
| 18 | IgG deficiency (HP:0004315) | 2.83269383 |
| 19 | Lipid accumulation in hepatocytes (HP:0006561) | 2.76159750 |
| 20 | Optic disc pallor (HP:0000543) | 2.75536252 |
| 21 | 3-Methylglutaconic aciduria (HP:0003535) | 2.67631080 |
| 22 | Nephronophthisis (HP:0000090) | 2.60747343 |
| 23 | Hepatic necrosis (HP:0002605) | 2.59648305 |
| 24 | Pendular nystagmus (HP:0012043) | 2.55311038 |
| 25 | Multiple enchondromatosis (HP:0005701) | 2.52958207 |
| 26 | IgA deficiency (HP:0002720) | 2.51142060 |
| 27 | Increased serum lactate (HP:0002151) | 2.45658060 |
| 28 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.38558381 |
| 29 | Birth length less than 3rd percentile (HP:0003561) | 2.36838634 |
| 30 | Abnormality of midbrain morphology (HP:0002418) | 2.35016904 |
| 31 | Molar tooth sign on MRI (HP:0002419) | 2.35016904 |
| 32 | Congenital, generalized hypertrichosis (HP:0004540) | 2.32516141 |
| 33 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 2.31420576 |
| 34 | Hypomagnesemia (HP:0002917) | 2.25641226 |
| 35 | Ependymoma (HP:0002888) | 2.23600671 |
| 36 | Reticulocytopenia (HP:0001896) | 2.23360915 |
| 37 | Retrobulbar optic neuritis (HP:0100654) | 2.21580793 |
| 38 | Optic neuritis (HP:0100653) | 2.21580793 |
| 39 | Medial flaring of the eyebrow (HP:0010747) | 2.16364748 |
| 40 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.16317825 |
| 41 | Abnormality of alanine metabolism (HP:0010916) | 2.16317825 |
| 42 | Hyperalaninemia (HP:0003348) | 2.16317825 |
| 43 | Biliary tract neoplasm (HP:0100574) | 2.15003998 |
| 44 | Leukodystrophy (HP:0002415) | 2.14425344 |
| 45 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.14322380 |
| 46 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.14322380 |
| 47 | Hypoplasia of the radius (HP:0002984) | 2.13942524 |
| 48 | Abnormality of the renal medulla (HP:0100957) | 2.11839758 |
| 49 | Increased IgM level (HP:0003496) | 2.10312451 |
| 50 | Optic nerve hypoplasia (HP:0000609) | 2.08627586 |
| 51 | B lymphocytopenia (HP:0010976) | 2.04206233 |
| 52 | Abnormality of magnesium homeostasis (HP:0004921) | 2.02059059 |
| 53 | Renal Fanconi syndrome (HP:0001994) | 2.01906976 |
| 54 | Central scotoma (HP:0000603) | 2.00215923 |
| 55 | Abnormality of the renal cortex (HP:0011035) | 1.99236260 |
| 56 | Exercise intolerance (HP:0003546) | 1.97209569 |
| 57 | Lethargy (HP:0001254) | 1.93146344 |
| 58 | Respiratory difficulties (HP:0002880) | 1.92712727 |
| 59 | Lactic acidosis (HP:0003128) | 1.91940116 |
| 60 | Abnormality of B cell number (HP:0010975) | 1.91549351 |
| 61 | Pancreatic cysts (HP:0001737) | 1.89386511 |
| 62 | Aplastic anemia (HP:0001915) | 1.88990593 |
| 63 | Abolished electroretinogram (ERG) (HP:0000550) | 1.88714341 |
| 64 | Septo-optic dysplasia (HP:0100842) | 1.86361287 |
| 65 | Bile duct proliferation (HP:0001408) | 1.84411948 |
| 66 | Abnormal biliary tract physiology (HP:0012439) | 1.84411948 |
| 67 | Forearm undergrowth (HP:0009821) | 1.83850929 |
| 68 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.83585421 |
| 69 | IgM deficiency (HP:0002850) | 1.82738865 |
| 70 | Inability to walk (HP:0002540) | 1.82272159 |
| 71 | Supernumerary spleens (HP:0009799) | 1.80743466 |
| 72 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 1.80034417 |
| 73 | Hypoplasia of the ulna (HP:0003022) | 1.79432732 |
| 74 | Meckel diverticulum (HP:0002245) | 1.76028233 |
| 75 | Carpal bone hypoplasia (HP:0001498) | 1.75703064 |
| 76 | Aplasia/Hypoplasia of the ulna (HP:0006495) | 1.74911264 |
| 77 | Tetany (HP:0001281) | 1.74025673 |
| 78 | Exertional dyspnea (HP:0002875) | 1.73636007 |
| 79 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 1.72707589 |
| 80 | Rhabdomyosarcoma (HP:0002859) | 1.72123271 |
| 81 | Respiratory failure (HP:0002878) | 1.71402553 |
| 82 | Asplenia (HP:0001746) | 1.68773756 |
| 83 | Conjunctival hamartoma (HP:0100780) | 1.68433908 |
| 84 | Cleft eyelid (HP:0000625) | 1.68254168 |
| 85 | Growth hormone deficiency (HP:0000824) | 1.67496455 |
| 86 | Volvulus (HP:0002580) | 1.67003010 |
| 87 | Abnormal spermatogenesis (HP:0008669) | 1.66825627 |
| 88 | Abnormality of chromosome stability (HP:0003220) | 1.65819600 |
| 89 | Chromsome breakage (HP:0040012) | 1.65225232 |
| 90 | Oligodactyly (hands) (HP:0001180) | 1.65004955 |
| 91 | Horseshoe kidney (HP:0000085) | 1.64944103 |
| 92 | Ectopic kidney (HP:0000086) | 1.64585989 |
| 93 | Abnormality of T cells (HP:0002843) | 1.63797110 |
| 94 | Neutropenia (HP:0001875) | 1.63179414 |
| 95 | Hypoproteinemia (HP:0003075) | 1.63094373 |
| 96 | Abnormality of the middle phalanx of the 5th finger (HP:0004219) | 1.62687375 |
| 97 | Breast carcinoma (HP:0003002) | 1.62396612 |
| 98 | Tubular atrophy (HP:0000092) | 1.62349787 |
| 99 | Abnormality of the ileum (HP:0001549) | 1.61874584 |
| 100 | Type II lissencephaly (HP:0007260) | 1.61787893 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PBK | 4.34365340 |
| 2 | TSSK6 | 3.74588840 |
| 3 | STK16 | 3.69655513 |
| 4 | NME1 | 3.61174322 |
| 5 | NUAK1 | 3.26035793 |
| 6 | TNIK | 2.93685773 |
| 7 | BUB1 | 2.92946024 |
| 8 | MST4 | 2.68286319 |
| 9 | PINK1 | 2.57692506 |
| 10 | TAOK1 | 2.53804675 |
| 11 | WNK3 | 2.47331567 |
| 12 | WNK4 | 2.45349359 |
| 13 | TXK | 2.27771101 |
| 14 | ADRBK2 | 2.19577600 |
| 15 | SRPK1 | 2.14022005 |
| 16 | ZAK | 2.13507942 |
| 17 | MAP2K6 | 2.04695751 |
| 18 | GRK1 | 1.81890643 |
| 19 | MKNK2 | 1.79370825 |
| 20 | MAP4K1 | 1.79183349 |
| 21 | NLK | 1.67930003 |
| 22 | EIF2AK1 | 1.54302860 |
| 23 | NEK1 | 1.51844705 |
| 24 | ALK | 1.45242784 |
| 25 | EIF2AK3 | 1.44918903 |
| 26 | PASK | 1.41645811 |
| 27 | MKNK1 | 1.38506164 |
| 28 | TLK1 | 1.38398206 |
| 29 | PLK3 | 1.36461884 |
| 30 | TAOK3 | 1.33675418 |
| 31 | TRIM28 | 1.28074276 |
| 32 | STK39 | 1.27676470 |
| 33 | OXSR1 | 1.25139696 |
| 34 | CDC7 | 1.22914127 |
| 35 | FRK | 1.18364130 |
| 36 | VRK2 | 1.12534801 |
| 37 | DYRK2 | 1.12450652 |
| 38 | TAF1 | 1.07335073 |
| 39 | CASK | 1.00871136 |
| 40 | PRKG2 | 0.96478634 |
| 41 | WEE1 | 0.96024106 |
| 42 | BMPR1B | 0.95880836 |
| 43 | TTK | 0.93892142 |
| 44 | VRK1 | 0.93118387 |
| 45 | BCKDK | 0.91166179 |
| 46 | PDK2 | 0.88613269 |
| 47 | EIF2AK2 | 0.82583508 |
| 48 | TGFBR1 | 0.81764349 |
| 49 | DMPK | 0.81183117 |
| 50 | PLK1 | 0.71608637 |
| 51 | ITK | 0.66028774 |
| 52 | NME2 | 0.64189306 |
| 53 | MAPKAPK3 | 0.62289237 |
| 54 | PIK3CA | 0.59793958 |
| 55 | PRKCG | 0.57481512 |
| 56 | PRKCQ | 0.57013570 |
| 57 | PHKG1 | 0.54795450 |
| 58 | PHKG2 | 0.54795450 |
| 59 | TIE1 | 0.52001470 |
| 60 | PLK4 | 0.49560402 |
| 61 | CSNK1E | 0.48623266 |
| 62 | CAMK2A | 0.46987078 |
| 63 | TAOK2 | 0.45515063 |
| 64 | AURKB | 0.44078953 |
| 65 | CDK3 | 0.43867561 |
| 66 | MAP3K4 | 0.43236586 |
| 67 | WNK1 | 0.41885037 |
| 68 | LCK | 0.40778648 |
| 69 | STK4 | 0.40049884 |
| 70 | PRKG1 | 0.37774286 |
| 71 | FGFR1 | 0.36822894 |
| 72 | TYRO3 | 0.36685134 |
| 73 | INSRR | 0.36659067 |
| 74 | CSNK2A2 | 0.36332471 |
| 75 | CDK7 | 0.35552360 |
| 76 | TEC | 0.34488250 |
| 77 | ATR | 0.31518322 |
| 78 | CAMK1 | 0.29699703 |
| 79 | RPS6KA5 | 0.29435735 |
| 80 | CLK1 | 0.28513485 |
| 81 | ZAP70 | 0.28025249 |
| 82 | MAP4K2 | 0.27776527 |
| 83 | MAP3K11 | 0.27414038 |
| 84 | SYK | 0.27311518 |
| 85 | STK38L | 0.27291993 |
| 86 | BCR | 0.25668297 |
| 87 | PIK3CG | 0.25664997 |
| 88 | FES | 0.25637021 |
| 89 | IRAK3 | 0.25342941 |
| 90 | NEK2 | 0.25009653 |
| 91 | PKN1 | 0.24567813 |
| 92 | MAP2K2 | 0.23669024 |
| 93 | PIM1 | 0.23344025 |
| 94 | CSNK2A1 | 0.22726266 |
| 95 | MINK1 | 0.22274798 |
| 96 | MATK | 0.20902218 |
| 97 | CDK19 | 0.20679389 |
| 98 | DYRK1B | 0.20608260 |
| 99 | STK11 | 0.19217574 |
| 100 | ATM | 0.19027673 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.07111864 |
| 2 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.29793019 |
| 3 | RNA polymerase_Homo sapiens_hsa03020 | 3.00582698 |
| 4 | Ribosome_Homo sapiens_hsa03010 | 2.97445194 |
| 5 | Asthma_Homo sapiens_hsa05310 | 2.84778790 |
| 6 | Protein export_Homo sapiens_hsa03060 | 2.84566242 |
| 7 | Mismatch repair_Homo sapiens_hsa03430 | 2.62293042 |
| 8 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.59800976 |
| 9 | Basal transcription factors_Homo sapiens_hsa03022 | 2.45252374 |
| 10 | Homologous recombination_Homo sapiens_hsa03440 | 2.42806484 |
| 11 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.28848879 |
| 12 | Parkinsons disease_Homo sapiens_hsa05012 | 2.28261735 |
| 13 | Allograft rejection_Homo sapiens_hsa05330 | 2.26370716 |
| 14 | RNA degradation_Homo sapiens_hsa03018 | 2.09756488 |
| 15 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.09754335 |
| 16 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.09049095 |
| 17 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.05194702 |
| 18 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 2.04584827 |
| 19 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.94606358 |
| 20 | RNA transport_Homo sapiens_hsa03013 | 1.78942258 |
| 21 | DNA replication_Homo sapiens_hsa03030 | 1.76880275 |
| 22 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.75911391 |
| 23 | Huntingtons disease_Homo sapiens_hsa05016 | 1.57994302 |
| 24 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.56462948 |
| 25 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.54310973 |
| 26 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.53246682 |
| 27 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.44353047 |
| 28 | Spliceosome_Homo sapiens_hsa03040 | 1.37733607 |
| 29 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.37040213 |
| 30 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.32686956 |
| 31 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.30817828 |
| 32 | Phototransduction_Homo sapiens_hsa04744 | 1.26872983 |
| 33 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.24471308 |
| 34 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.23543558 |
| 35 | Alzheimers disease_Homo sapiens_hsa05010 | 1.21798474 |
| 36 | Purine metabolism_Homo sapiens_hsa00230 | 1.16429470 |
| 37 | Nicotine addiction_Homo sapiens_hsa05033 | 1.15798821 |
| 38 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.13638683 |
| 39 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.09868098 |
| 40 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.06958161 |
| 41 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.04218527 |
| 42 | Base excision repair_Homo sapiens_hsa03410 | 1.02467760 |
| 43 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.98446774 |
| 44 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.96068261 |
| 45 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.94168879 |
| 46 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.92701513 |
| 47 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.92642740 |
| 48 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.86852588 |
| 49 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.86765442 |
| 50 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.86735452 |
| 51 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.86735313 |
| 52 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.85158769 |
| 53 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.84505833 |
| 54 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.79596225 |
| 55 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.78974524 |
| 56 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.77736844 |
| 57 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.71406863 |
| 58 | Morphine addiction_Homo sapiens_hsa05032 | 0.68422653 |
| 59 | Peroxisome_Homo sapiens_hsa04146 | 0.67847870 |
| 60 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.61965008 |
| 61 | Cell cycle_Homo sapiens_hsa04110 | 0.59119207 |
| 62 | GABAergic synapse_Homo sapiens_hsa04727 | 0.58502846 |
| 63 | Metabolic pathways_Homo sapiens_hsa01100 | 0.57423763 |
| 64 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.57312865 |
| 65 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.56997681 |
| 66 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.54622741 |
| 67 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.52517548 |
| 68 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.51568967 |
| 69 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.50933404 |
| 70 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.50473983 |
| 71 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.50319254 |
| 72 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.48819597 |
| 73 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.47435189 |
| 74 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.47385426 |
| 75 | Olfactory transduction_Homo sapiens_hsa04740 | 0.46488626 |
| 76 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.46331326 |
| 77 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.45808537 |
| 78 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.45103209 |
| 79 | Taste transduction_Homo sapiens_hsa04742 | 0.44823569 |
| 80 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.44739000 |
| 81 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.42657060 |
| 82 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.40022482 |
| 83 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.37889711 |
| 84 | Retinol metabolism_Homo sapiens_hsa00830 | 0.36413785 |
| 85 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.35105533 |
| 86 | Salivary secretion_Homo sapiens_hsa04970 | 0.34717802 |
| 87 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.34503145 |
| 88 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.30497416 |
| 89 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.30109843 |
| 90 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.28538920 |
| 91 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.28121604 |
| 92 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.28043633 |
| 93 | Circadian entrainment_Homo sapiens_hsa04713 | 0.27224304 |
| 94 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.26617333 |
| 95 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.25415375 |
| 96 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.23784126 |
| 97 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.22664894 |
| 98 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.22140865 |
| 99 | Circadian rhythm_Homo sapiens_hsa04710 | 0.21853908 |
| 100 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.21004382 |

