RPL5P32

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1energy coupled proton transport, down electrochemical gradient (GO:0015985)5.80558021
2ATP synthesis coupled proton transport (GO:0015986)5.80558021
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.63000848
4response to pheromone (GO:0019236)5.46539706
5mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.76860868
6mitochondrial respiratory chain complex I assembly (GO:0032981)4.76860868
7NADH dehydrogenase complex assembly (GO:0010257)4.76860868
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.62655348
9protein neddylation (GO:0045116)4.52123633
10protein complex biogenesis (GO:0070271)4.50378339
11establishment of protein localization to mitochondrial membrane (GO:0090151)4.30775068
12chaperone-mediated protein transport (GO:0072321)4.25085668
13respiratory electron transport chain (GO:0022904)4.24619827
14electron transport chain (GO:0022900)4.23490638
15secondary metabolite biosynthetic process (GO:0044550)4.13186271
16melanin biosynthetic process (GO:0042438)4.12996278
17mitochondrial respiratory chain complex assembly (GO:0033108)4.12154172
18RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.01009901
19tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.01009901
20behavioral response to nicotine (GO:0035095)3.99467890
21protein polyglutamylation (GO:0018095)3.94037591
22melanin metabolic process (GO:0006582)3.73987159
23piRNA metabolic process (GO:0034587)3.71873377
24viral transcription (GO:0019083)3.68811782
25epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.63458257
26translational termination (GO:0006415)3.62296342
27ribosomal small subunit assembly (GO:0000028)3.61903879
28epithelial cilium movement (GO:0003351)3.59132482
29ribosomal large subunit biogenesis (GO:0042273)3.58809425
30regulation of cellular respiration (GO:0043457)3.52215378
31regulation of cilium movement (GO:0003352)3.50882461
32transcription elongation from RNA polymerase III promoter (GO:0006385)3.49512287
33termination of RNA polymerase III transcription (GO:0006386)3.49512287
34preassembly of GPI anchor in ER membrane (GO:0016254)3.48489503
35ATP biosynthetic process (GO:0006754)3.44095309
36SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.39770739
37hydrogen ion transmembrane transport (GO:1902600)3.37552951
38cotranslational protein targeting to membrane (GO:0006613)3.35971644
39protein targeting to ER (GO:0045047)3.34828232
40proton transport (GO:0015992)3.28034392
41DNA deamination (GO:0045006)3.26467497
42hydrogen transport (GO:0006818)3.22800270
43ketone body metabolic process (GO:1902224)3.19838943
44platelet dense granule organization (GO:0060155)3.17707583
45establishment of protein localization to endoplasmic reticulum (GO:0072599)3.17406171
46negative regulation of heart rate (GO:0010459)3.17272584
47purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.17066961
48protein localization to endoplasmic reticulum (GO:0070972)3.16819331
49kynurenine metabolic process (GO:0070189)3.12887526
50indolalkylamine metabolic process (GO:0006586)3.12734384
51nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.12167988
52exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.11803905
53inositol phosphate catabolic process (GO:0071545)3.10672920
54purine nucleoside triphosphate biosynthetic process (GO:0009145)3.10250835
55response to redox state (GO:0051775)3.09084907
56aldehyde catabolic process (GO:0046185)3.02886684
57DNA methylation involved in gamete generation (GO:0043046)3.02656005
58acrosome reaction (GO:0007340)2.97286987
59translational elongation (GO:0006414)2.96369871
60fucose catabolic process (GO:0019317)2.94607296
61L-fucose metabolic process (GO:0042354)2.94607296
62L-fucose catabolic process (GO:0042355)2.94607296
63positive regulation of protein homodimerization activity (GO:0090073)2.89046896
64cellular ketone body metabolic process (GO:0046950)2.86101956
65regulation of microtubule-based movement (GO:0060632)2.83893550
66water-soluble vitamin biosynthetic process (GO:0042364)2.81960069
67synaptic transmission, cholinergic (GO:0007271)2.81322838
68glycerophospholipid catabolic process (GO:0046475)2.81253338
69tryptophan metabolic process (GO:0006568)2.81001978
70rRNA modification (GO:0000154)2.79981072
71cellular component biogenesis (GO:0044085)2.77934603
72indole-containing compound catabolic process (GO:0042436)2.77241502
73indolalkylamine catabolic process (GO:0046218)2.77241502
74tryptophan catabolic process (GO:0006569)2.77241502
75cellular protein complex disassembly (GO:0043624)2.76169891
76phosphorylated carbohydrate dephosphorylation (GO:0046838)2.75404328
77inositol phosphate dephosphorylation (GO:0046855)2.75404328
78sperm motility (GO:0030317)2.75272314
79negative regulation of mast cell activation (GO:0033004)2.74880503
80detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.73724253
81maturation of SSU-rRNA (GO:0030490)2.73315216
82respiratory chain complex IV assembly (GO:0008535)2.72306791
83viral life cycle (GO:0019058)2.68150277
84ribonucleoside triphosphate biosynthetic process (GO:0009201)2.67613886
85polyol catabolic process (GO:0046174)2.65884239
86multicellular organism reproduction (GO:0032504)2.63337132
87tRNA processing (GO:0008033)2.63026717
88GPI anchor metabolic process (GO:0006505)2.62281563
89nonmotile primary cilium assembly (GO:0035058)2.59407144
90GPI anchor biosynthetic process (GO:0006506)2.58738559
91rRNA catabolic process (GO:0016075)2.58438108
92translation (GO:0006412)2.57200007
93maturation of 5.8S rRNA (GO:0000460)2.57125922
94cilium movement (GO:0003341)2.55911560
95regulation of mitochondrial translation (GO:0070129)2.55191067
96axonemal dynein complex assembly (GO:0070286)2.52536112
97intracellular protein transmembrane import (GO:0044743)2.51198960
98anterograde synaptic vesicle transport (GO:0048490)2.50721733
99axoneme assembly (GO:0035082)2.49958030
100anterograde axon cargo transport (GO:0008089)2.48878585

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.67585077
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.33522037
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.31406808
4EZH2_22144423_ChIP-Seq_EOC_Human3.22482795
5ZNF274_21170338_ChIP-Seq_K562_Hela3.05620639
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.03880128
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.01308796
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.73856945
9VDR_22108803_ChIP-Seq_LS180_Human2.60865526
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.55837783
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.48124083
12TAF15_26573619_Chip-Seq_HEK293_Human2.44978530
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.06011929
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.02596283
15FLI1_27457419_Chip-Seq_LIVER_Mouse1.93296285
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89594609
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.86926518
18VDR_23849224_ChIP-Seq_CD4+_Human1.86314921
19TP53_22573176_ChIP-Seq_HFKS_Human1.85450517
20IRF1_19129219_ChIP-ChIP_H3396_Human1.80369159
21BP1_19119308_ChIP-ChIP_Hs578T_Human1.80214790
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.74926718
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.74274771
24P300_19829295_ChIP-Seq_ESCs_Human1.67371200
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61983001
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57435789
27GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.56609275
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54709539
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53252178
30FUS_26573619_Chip-Seq_HEK293_Human1.52823536
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.52025565
32EWS_26573619_Chip-Seq_HEK293_Human1.51954057
33MYC_18940864_ChIP-ChIP_HL60_Human1.50666872
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50070257
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50042794
36ELK1_19687146_ChIP-ChIP_HELA_Human1.47659624
37FOXP3_21729870_ChIP-Seq_TREG_Human1.43137934
38ETV2_25802403_ChIP-Seq_MESCs_Mouse1.42137452
39CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.41622425
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.41246478
41CBP_20019798_ChIP-Seq_JUKART_Human1.40664101
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40664101
43ER_23166858_ChIP-Seq_MCF-7_Human1.37255936
44NCOR_22424771_ChIP-Seq_293T_Human1.37043419
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34547745
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.34004769
47GATA3_21878914_ChIP-Seq_MCF-7_Human1.33900378
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33013991
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.32963702
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32963702
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31974134
52IGF1R_20145208_ChIP-Seq_DFB_Human1.31827540
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.31361667
54MYC_18555785_ChIP-Seq_MESCs_Mouse1.29388869
55FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.28324627
56AUTS2_25519132_ChIP-Seq_293T-REX_Human1.26669669
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26215814
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26215814
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25651289
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25107578
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22506648
62SOX2_19829295_ChIP-Seq_ESCs_Human1.21531507
63NANOG_19829295_ChIP-Seq_ESCs_Human1.21531507
64ERA_21632823_ChIP-Seq_H3396_Human1.19976466
65AR_20517297_ChIP-Seq_VCAP_Human1.19945327
66GBX2_23144817_ChIP-Seq_PC3_Human1.17499070
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17336989
68BCAT_22108803_ChIP-Seq_LS180_Human1.13763903
69NANOG_20526341_ChIP-Seq_ESCs_Human1.13020433
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.12336703
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11366501
72AR_25329375_ChIP-Seq_VCAP_Human1.10346058
73MYC_19829295_ChIP-Seq_ESCs_Human1.10109938
74ERG_20517297_ChIP-Seq_VCAP_Human1.10013413
75SALL1_21062744_ChIP-ChIP_HESCs_Human1.09008622
76EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08921490
77EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08594457
78TAF2_19829295_ChIP-Seq_ESCs_Human1.08545225
79GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07960546
80REST_21632747_ChIP-Seq_MESCs_Mouse1.07495105
81HOXB7_26014856_ChIP-Seq_BT474_Human1.06218847
82RNF2_27304074_Chip-Seq_NSC_Mouse1.05669415
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05633511
84FOXH1_21741376_ChIP-Seq_EPCs_Human1.03199383
85PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98549436
86SMAD3_21741376_ChIP-Seq_EPCs_Human0.97448551
87CREB1_15753290_ChIP-ChIP_HEK293T_Human0.97387861
88TCF4_22108803_ChIP-Seq_LS180_Human0.97063826
89CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95695322
90FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94137202
91TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93124987
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91106451
93TTF2_22483619_ChIP-Seq_HELA_Human0.90638758
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89993263
95RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.89420990
96MYC_18358816_ChIP-ChIP_MESCs_Mouse0.88488402
97RUNX2_22187159_ChIP-Seq_PCA_Human0.88273651
98JUN_21703547_ChIP-Seq_K562_Human0.88273362
99TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.86853640
100YY1_21170310_ChIP-Seq_MESCs_Mouse0.86254279

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation5.06964152
2MP0003136_yellow_coat_color4.12665768
3MP0006292_abnormal_olfactory_placode2.88113767
4MP0003878_abnormal_ear_physiology2.52249095
5MP0005377_hearing/vestibular/ear_phenot2.52249095
6MP0008877_abnormal_DNA_methylation2.38827830
7MP0004885_abnormal_endolymph2.35495793
8MP0004142_abnormal_muscle_tone2.22625204
9MP0003646_muscle_fatigue2.22240504
10MP0004147_increased_porphyrin_level2.21481153
11MP0005171_absent_coat_pigmentation2.18742923
12MP0003787_abnormal_imprinting2.00778835
13MP0009379_abnormal_foot_pigmentation1.99333131
14MP0005551_abnormal_eye_electrophysiolog1.96626553
15MP0001485_abnormal_pinna_reflex1.93935560
16MP0002102_abnormal_ear_morphology1.89192916
17MP0005075_abnormal_melanosome_morpholog1.88142215
18MP0002095_abnormal_skin_pigmentation1.85683202
19MP0008872_abnormal_physiological_respon1.84005264
20MP0003186_abnormal_redox_activity1.78107979
21MP0003806_abnormal_nucleotide_metabolis1.77359391
22MP0005410_abnormal_fertilization1.73746189
23MP0002163_abnormal_gland_morphology1.71954941
24MP0003011_delayed_dark_adaptation1.61382695
25MP0002638_abnormal_pupillary_reflex1.57794522
26MP0002938_white_spotting1.57319636
27MP0005646_abnormal_pituitary_gland1.57068443
28MP0008875_abnormal_xenobiotic_pharmacok1.56947825
29MP0001835_abnormal_antigen_presentation1.54817053
30MP0005253_abnormal_eye_physiology1.52570307
31MP0001968_abnormal_touch/_nociception1.49783161
32MP0005423_abnormal_somatic_nervous1.49541588
33MP0006072_abnormal_retinal_apoptosis1.49539065
34MP0005645_abnormal_hypothalamus_physiol1.46896899
35MP0009745_abnormal_behavioral_response1.44249322
36MP0005379_endocrine/exocrine_gland_phen1.43234420
37MP0002272_abnormal_nervous_system1.41468573
38MP0005408_hypopigmentation1.39387870
39MP0001486_abnormal_startle_reflex1.38564354
40MP0005084_abnormal_gallbladder_morpholo1.38377604
41MP0000015_abnormal_ear_pigmentation1.37555776
42MP0002837_dystrophic_cardiac_calcinosis1.36680673
43MP0001984_abnormal_olfaction1.35239176
44MP0002736_abnormal_nociception_after1.34885903
45MP0004145_abnormal_muscle_electrophysio1.30612921
46MP0001905_abnormal_dopamine_level1.30138833
47MP0002735_abnormal_chemical_nociception1.26569582
48MP0003880_abnormal_central_pattern1.26128502
49MP0000371_diluted_coat_color1.20164777
50MP0004742_abnormal_vestibular_system1.19503551
51MP0003195_calcinosis1.18355505
52MP0001970_abnormal_pain_threshold1.16386860
53MP0006036_abnormal_mitochondrial_physio1.14756687
54MP0001986_abnormal_taste_sensitivity1.12775193
55MP0004043_abnormal_pH_regulation1.11923238
56MP0008789_abnormal_olfactory_epithelium1.10759933
57MP0002653_abnormal_ependyma_morphology1.09508233
58MP0002557_abnormal_social/conspecific_i1.07585115
59MP0005670_abnormal_white_adipose1.07535893
60MP0002572_abnormal_emotion/affect_behav1.06393380
61MP0001324_abnormal_eye_pigmentation1.02974226
62MP0001440_abnormal_grooming_behavior1.02953082
63MP0000230_abnormal_systemic_arterial1.02566529
64MP0006276_abnormal_autonomic_nervous1.01935378
65MP0005671_abnormal_response_to1.00146365
66MP0009046_muscle_twitch0.99040063
67MP0005332_abnormal_amino_acid0.98949800
68MP0008995_early_reproductive_senescence0.98114327
69MP0001919_abnormal_reproductive_system0.93627697
70MP0004133_heterotaxia0.93368427
71MP0004381_abnormal_hair_follicle0.93194972
72MP0005174_abnormal_tail_pigmentation0.92043840
73MP0003718_maternal_effect0.90478657
74MP0002876_abnormal_thyroid_physiology0.89873465
75MP0001963_abnormal_hearing_physiology0.88820140
76MP0002067_abnormal_sensory_capabilities0.88335914
77MP0002064_seizures0.87157340
78MP0006035_abnormal_mitochondrial_morpho0.86365143
79MP0005389_reproductive_system_phenotype0.86006077
80MP0001293_anophthalmia0.85283442
81MP0001502_abnormal_circadian_rhythm0.85143811
82MP0008775_abnormal_heart_ventricle0.84691064
83MP0005195_abnormal_posterior_eye0.84472354
84MP0001501_abnormal_sleep_pattern0.84050144
85MP0001529_abnormal_vocalization0.82721609
86MP0002752_abnormal_somatic_nervous0.81334877
87MP0001929_abnormal_gametogenesis0.81313122
88MP0003786_premature_aging0.81312189
89MP0009764_decreased_sensitivity_to0.80930661
90MP0003122_maternal_imprinting0.80094735
91MP0003698_abnormal_male_reproductive0.78856825
92MP0002229_neurodegeneration0.78333238
93MP0003121_genomic_imprinting0.77827950
94MP0005636_abnormal_mineral_homeostasis0.76746231
95MP0002733_abnormal_thermal_nociception0.76286297
96MP0003693_abnormal_embryo_hatching0.75736004
97MP0005394_taste/olfaction_phenotype0.73345088
98MP0005499_abnormal_olfactory_system0.73345088
99MP0000026_abnormal_inner_ear0.73028501
100MP0002210_abnormal_sex_determination0.72415020

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.45238418
2Mitochondrial inheritance (HP:0001427)4.06876239
3Increased CSF lactate (HP:0002490)3.91148833
4Acute encephalopathy (HP:0006846)3.90473968
5Abnormal mitochondria in muscle tissue (HP:0008316)3.86223334
6Progressive macrocephaly (HP:0004481)3.77411582
7Congenital stationary night blindness (HP:0007642)3.62755338
8Lipid accumulation in hepatocytes (HP:0006561)3.61116080
9Nephronophthisis (HP:0000090)3.59100954
10Abnormality of midbrain morphology (HP:0002418)3.58721035
11Molar tooth sign on MRI (HP:0002419)3.58721035
12Increased hepatocellular lipid droplets (HP:0006565)3.50101851
13Absent/shortened dynein arms (HP:0200106)3.33675306
14Dynein arm defect of respiratory motile cilia (HP:0012255)3.33675306
15Hepatocellular necrosis (HP:0001404)3.27006005
16Abnormality of cells of the erythroid lineage (HP:0012130)3.13631633
17Renal Fanconi syndrome (HP:0001994)3.13176843
18Methylmalonic acidemia (HP:0002912)3.08863100
19Optic disc pallor (HP:0000543)3.02951883
20Hepatic necrosis (HP:0002605)2.99816407
21Abnormality of the renal medulla (HP:0100957)2.97324893
22Hypoplasia of the fovea (HP:0007750)2.96566654
23Aplasia/Hypoplasia of the fovea (HP:0008060)2.96566654
24Pancreatic cysts (HP:0001737)2.92137961
25Cerebral edema (HP:0002181)2.88223031
26Decreased central vision (HP:0007663)2.85628781
27Abnormal number of erythroid precursors (HP:0012131)2.82670509
28Type II lissencephaly (HP:0007260)2.66719319
29Abnormal rod and cone electroretinograms (HP:0008323)2.63977720
30Pancreatic fibrosis (HP:0100732)2.60173449
31Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.58014454
32Abnormality of the renal cortex (HP:0011035)2.57751216
333-Methylglutaconic aciduria (HP:0003535)2.56089105
34Reticulocytopenia (HP:0001896)2.53898072
35Abnormality of the fovea (HP:0000493)2.49901185
36Methylmalonic aciduria (HP:0012120)2.48040879
37Congenital, generalized hypertrichosis (HP:0004540)2.45800875
38Renal cortical cysts (HP:0000803)2.41727469
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.38772286
40Abnormality of alanine metabolism (HP:0010916)2.38772286
41Hyperalaninemia (HP:0003348)2.38772286
42Macrocytic anemia (HP:0001972)2.38374445
43Increased serum lactate (HP:0002151)2.34508463
44Exertional dyspnea (HP:0002875)2.33384355
45Increased intramyocellular lipid droplets (HP:0012240)2.33031934
46Medial flaring of the eyebrow (HP:0010747)2.31942903
47Aplasia/Hypoplasia of the macula (HP:0008059)2.31404600
48Sclerocornea (HP:0000647)2.30851100
49Abnormality of renal resorption (HP:0011038)2.30679847
50True hermaphroditism (HP:0010459)2.29804384
51Abnormality of urine glucose concentration (HP:0011016)2.27199533
52Glycosuria (HP:0003076)2.27199533
53Leukodystrophy (HP:0002415)2.26584392
54Abolished electroretinogram (ERG) (HP:0000550)2.24918175
55Attenuation of retinal blood vessels (HP:0007843)2.22715278
56Lactic acidosis (HP:0003128)2.22266247
57Abnormal respiratory epithelium morphology (HP:0012253)2.21280627
58Abnormal respiratory motile cilium morphology (HP:0005938)2.21280627
59Absent rod-and cone-mediated responses on ERG (HP:0007688)2.21020767
60Decreased electroretinogram (ERG) amplitude (HP:0000654)2.19003563
61Aplasia/Hypoplasia affecting the retina (HP:0008061)2.15201719
62Increased muscle lipid content (HP:0009058)2.11119702
63Pendular nystagmus (HP:0012043)2.07281079
64Polydipsia (HP:0001959)2.06354844
65Abnormal drinking behavior (HP:0030082)2.06354844
66Abnormal ciliary motility (HP:0012262)2.05730240
67Elevated erythrocyte sedimentation rate (HP:0003565)2.03367843
68Abnormality of the vitamin B12 metabolism (HP:0004341)2.02749273
69Optic nerve hypoplasia (HP:0000609)2.02414817
70Respiratory failure (HP:0002878)2.02285540
71Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.01176226
72Lethargy (HP:0001254)2.00262439
73Hypothermia (HP:0002045)1.99897254
74Agitation (HP:0000713)1.99467457
75IgG deficiency (HP:0004315)1.97849822
76Type 2 muscle fiber atrophy (HP:0003554)1.95865813
77Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.92792693
78Abnormality of vitamin B metabolism (HP:0004340)1.89754699
79Bony spicule pigmentary retinopathy (HP:0007737)1.89337429
80Concave nail (HP:0001598)1.88965440
81Septo-optic dysplasia (HP:0100842)1.87496146
82Adrenal hypoplasia (HP:0000835)1.85969722
83Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.85309350
84Polyuria (HP:0000103)1.85170686
85Supernumerary spleens (HP:0009799)1.83187294
86Gait imbalance (HP:0002141)1.82951427
87Cerebellar dysplasia (HP:0007033)1.81965149
88Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.79527350
89Stomatitis (HP:0010280)1.74420618
90Exercise intolerance (HP:0003546)1.72773715
91Congenital sensorineural hearing impairment (HP:0008527)1.72555878
92Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.72523643
93Degeneration of the lateral corticospinal tracts (HP:0002314)1.72523643
94Abnormal urine output (HP:0012590)1.71967651
95Postaxial foot polydactyly (HP:0001830)1.71803719
96Abnormal spermatogenesis (HP:0008669)1.70344240
97Respiratory difficulties (HP:0002880)1.69321592
98Retinal dysplasia (HP:0007973)1.68604579
99Congenital primary aphakia (HP:0007707)1.68207922
100Increased corneal curvature (HP:0100692)1.67090041

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.19037010
2TLK13.30606854
3BMPR1B3.09856001
4ZAK2.79680232
5WNK42.74313372
6BMPR22.32990189
7TXK2.30475819
8NUAK12.24232377
9FRK2.23007762
10SCYL22.14476305
11GRK12.12624813
12ADRBK21.96387122
13VRK21.92403372
14INSRR1.89478822
15DYRK21.77715486
16WNK31.76896109
17CDK191.72577097
18STK161.70716702
19ACVR1B1.65033313
20CASK1.64150007
21TRIM281.62691757
22BCKDK1.52941312
23MAP4K21.52268329
24MARK11.46533451
25STK391.46249254
26PLK41.42862899
27TIE11.41393918
28CSNK1G31.23563431
29CSNK1G21.19514633
30ERBB31.17523987
31OXSR11.09303001
32PDK21.07624597
33WEE11.05756775
34CSNK1A1L1.01487735
35MST41.00644949
36TGFBR10.97058755
37NEK20.94642865
38LIMK10.94168045
39VRK10.92595105
40MAP3K40.89540613
41CSNK1G10.88900625
42MAP2K70.88730215
43MAP2K40.83822591
44PHKG20.83706904
45PHKG10.83706904
46PLK30.81902641
47PAK30.79886451
48PINK10.78352684
49MARK30.75623735
50MAP3K110.75515326
51TEC0.75480469
52PLK20.74893607
53ADRBK10.73696462
54WNK10.72955685
55PRKCG0.68391868
56GRK60.68269950
57ILK0.67692113
58CDK30.64167693
59SRPK10.63729156
60MAPK130.61865542
61MKNK20.61548968
62MYLK0.60747242
63TAF10.59251850
64IKBKB0.58580563
65CAMK2A0.58051459
66EPHA40.56960810
67CSNK2A20.55491669
68BTK0.54939840
69PIK3CA0.54811818
70PLK10.53782307
71PRKACA0.53339828
72NME20.52155265
73MAP2K60.52081078
74NME10.52010032
75FES0.51415377
76NEK10.51239507
77CDK80.50719646
78AURKB0.50209381
79PRKCQ0.49912173
80SYK0.48174015
81LYN0.46833379
82ATR0.46025244
83MINK10.45969614
84CSNK2A10.44280193
85RPS6KA50.44143267
86DAPK20.44027419
87PIK3CG0.43337020
88MKNK10.43283113
89NTRK20.43229041
90OBSCN0.41293813
91PRKCA0.40693665
92CSNK1A10.40444293
93DAPK30.39620034
94PRKCE0.39096504
95EIF2AK20.38977259
96PKN10.37984158
97RPS6KA40.37499859
98KIT0.36370660
99TAOK30.36207564
100CAMK10.34974988

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.25008478
2Asthma_Homo sapiens_hsa053103.60286022
3Parkinsons disease_Homo sapiens_hsa050123.54790857
4Ribosome_Homo sapiens_hsa030103.42996332
5Protein export_Homo sapiens_hsa030602.73031207
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.67035553
7Proteasome_Homo sapiens_hsa030502.65414519
8Allograft rejection_Homo sapiens_hsa053302.43631506
9Alzheimers disease_Homo sapiens_hsa050102.40338713
10Huntingtons disease_Homo sapiens_hsa050162.34971502
11Autoimmune thyroid disease_Homo sapiens_hsa053202.34170206
12RNA polymerase_Homo sapiens_hsa030202.27545144
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.25275230
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.11640193
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.11005855
16Cardiac muscle contraction_Homo sapiens_hsa042602.07922648
17Homologous recombination_Homo sapiens_hsa034401.99451419
18Graft-versus-host disease_Homo sapiens_hsa053321.98578297
19Type I diabetes mellitus_Homo sapiens_hsa049401.94166808
20Linoleic acid metabolism_Homo sapiens_hsa005911.85644485
21Phototransduction_Homo sapiens_hsa047441.61054563
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.56506198
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48893862
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.41041680
25Basal transcription factors_Homo sapiens_hsa030221.36841046
26RNA degradation_Homo sapiens_hsa030181.32047819
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19365687
28Nicotine addiction_Homo sapiens_hsa050331.15609065
29Tryptophan metabolism_Homo sapiens_hsa003801.14314567
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13134708
31Butanoate metabolism_Homo sapiens_hsa006501.11211865
32Pyrimidine metabolism_Homo sapiens_hsa002401.08723214
33Base excision repair_Homo sapiens_hsa034101.08218873
34Fanconi anemia pathway_Homo sapiens_hsa034601.05786236
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05641504
36Nucleotide excision repair_Homo sapiens_hsa034201.02245508
37Propanoate metabolism_Homo sapiens_hsa006400.96881968
38One carbon pool by folate_Homo sapiens_hsa006700.95875635
39Arachidonic acid metabolism_Homo sapiens_hsa005900.95164298
40Purine metabolism_Homo sapiens_hsa002300.94794443
41Chemical carcinogenesis_Homo sapiens_hsa052040.94388151
42Olfactory transduction_Homo sapiens_hsa047400.93783089
43Peroxisome_Homo sapiens_hsa041460.91047594
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89604885
45Mismatch repair_Homo sapiens_hsa034300.87636337
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.86473076
47Sulfur relay system_Homo sapiens_hsa041220.84921823
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83841706
49Nitrogen metabolism_Homo sapiens_hsa009100.83385036
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82695698
51Collecting duct acid secretion_Homo sapiens_hsa049660.82527479
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81347578
53Fat digestion and absorption_Homo sapiens_hsa049750.75198574
54Rheumatoid arthritis_Homo sapiens_hsa053230.75164764
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74660225
56Caffeine metabolism_Homo sapiens_hsa002320.74643255
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72321394
58Metabolic pathways_Homo sapiens_hsa011000.71149162
59Ether lipid metabolism_Homo sapiens_hsa005650.69216497
60DNA replication_Homo sapiens_hsa030300.68428021
61Regulation of autophagy_Homo sapiens_hsa041400.65625521
62Tyrosine metabolism_Homo sapiens_hsa003500.65024455
63Antigen processing and presentation_Homo sapiens_hsa046120.64866175
64Morphine addiction_Homo sapiens_hsa050320.63899013
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.61846400
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59628140
67Glutathione metabolism_Homo sapiens_hsa004800.58563338
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56868637
69RNA transport_Homo sapiens_hsa030130.56740086
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.56149637
71Viral myocarditis_Homo sapiens_hsa054160.55491348
72Retinol metabolism_Homo sapiens_hsa008300.53197271
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.51357268
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.51206761
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49054950
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.48228842
77Staphylococcus aureus infection_Homo sapiens_hsa051500.46962154
78Folate biosynthesis_Homo sapiens_hsa007900.46692173
79Taste transduction_Homo sapiens_hsa047420.45649773
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45559767
81Serotonergic synapse_Homo sapiens_hsa047260.43054541
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41463788
83Vitamin digestion and absorption_Homo sapiens_hsa049770.40634442
84Sulfur metabolism_Homo sapiens_hsa009200.40278380
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.39878576
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37425164
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36335520
88Ovarian steroidogenesis_Homo sapiens_hsa049130.35526958
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35510841
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35079345
91Fatty acid degradation_Homo sapiens_hsa000710.34900014
92GABAergic synapse_Homo sapiens_hsa047270.33989861
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31805793
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31548455
95Glycerolipid metabolism_Homo sapiens_hsa005610.31372119
96beta-Alanine metabolism_Homo sapiens_hsa004100.29954376
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27618971
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26082197
99Systemic lupus erythematosus_Homo sapiens_hsa053220.24693211
100Fatty acid biosynthesis_Homo sapiens_hsa000610.24425310

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