RPL5P33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1meiotic chromosome segregation (GO:0045132)8.86703844
2rRNA catabolic process (GO:0016075)7.28753567
3histone H3-K4 trimethylation (GO:0080182)6.07738858
4snRNA processing (GO:0016180)5.50155696
5protein K11-linked deubiquitination (GO:0035871)5.44363122
6snRNA metabolic process (GO:0016073)4.98471663
7regulation of MHC class II biosynthetic process (GO:0045346)4.96940478
8UDP-N-acetylglucosamine metabolic process (GO:0006047)4.81130269
9mitochondrion degradation (GO:0000422)4.61578058
10peptidyl-threonine dephosphorylation (GO:0035970)4.53569661
11ncRNA catabolic process (GO:0034661)4.51297408
12positive regulation of triglyceride biosynthetic process (GO:0010867)4.46661434
13regulation of female receptivity (GO:0045924)4.44623454
14L-fucose catabolic process (GO:0042355)4.33861088
15fucose catabolic process (GO:0019317)4.33861088
16L-fucose metabolic process (GO:0042354)4.33861088
17positive regulation of histone H3-K4 methylation (GO:0051571)4.28462342
18axonemal dynein complex assembly (GO:0070286)4.24136883
19maturation of SSU-rRNA (GO:0030490)4.03208035
20kynurenine metabolic process (GO:0070189)4.02554685
21female mating behavior (GO:0060180)3.99528492
22phosphatidylinositol acyl-chain remodeling (GO:0036149)3.99494413
23reciprocal DNA recombination (GO:0035825)3.96800351
24reciprocal meiotic recombination (GO:0007131)3.96800351
25N-acetylneuraminate metabolic process (GO:0006054)3.96474725
26C-terminal protein lipidation (GO:0006501)3.95439151
27auditory receptor cell stereocilium organization (GO:0060088)3.79856085
28establishment of protein localization to mitochondrial membrane (GO:0090151)3.78745539
29rRNA methylation (GO:0031167)3.74904054
30rRNA modification (GO:0000154)3.73685876
31mismatch repair (GO:0006298)3.72928808
32phosphatidylserine acyl-chain remodeling (GO:0036150)3.71695617
33tryptophan catabolic process (GO:0006569)3.71313416
34indole-containing compound catabolic process (GO:0042436)3.71313416
35indolalkylamine catabolic process (GO:0046218)3.71313416
36base-excision repair, AP site formation (GO:0006285)3.61199529
37C-terminal protein amino acid modification (GO:0018410)3.55759504
38acrosome assembly (GO:0001675)3.54562911
39nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.50371782
40regulation of triglyceride biosynthetic process (GO:0010866)3.46679811
41inner ear receptor stereocilium organization (GO:0060122)3.45424853
42epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.40600454
43N-acetylglucosamine metabolic process (GO:0006044)3.38289335
44behavioral response to nicotine (GO:0035095)3.33953553
45peptidyl-lysine trimethylation (GO:0018023)3.32854722
46exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.32792329
47protein K63-linked deubiquitination (GO:0070536)3.22640350
48cellular response to exogenous dsRNA (GO:0071360)3.22092830
49auditory receptor cell differentiation (GO:0042491)3.21027949
50protein polyglutamylation (GO:0018095)3.18186564
51nucleobase biosynthetic process (GO:0046112)3.17526211
52phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.16284873
53water-soluble vitamin biosynthetic process (GO:0042364)3.13543975
54positive regulation of fatty acid oxidation (GO:0046321)3.11336696
55tryptophan metabolic process (GO:0006568)3.10751160
56energy coupled proton transport, down electrochemical gradient (GO:0015985)3.10625923
57ATP synthesis coupled proton transport (GO:0015986)3.10625923
58indolalkylamine metabolic process (GO:0006586)3.08080489
59positive regulation of defense response to virus by host (GO:0002230)3.07801861
60positive regulation of fatty acid beta-oxidation (GO:0032000)3.05293860
61chaperone-mediated protein transport (GO:0072321)3.03926814
62mitochondrial respiratory chain complex I assembly (GO:0032981)3.02411451
63NADH dehydrogenase complex assembly (GO:0010257)3.02411451
64mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.02411451
65ribosomal small subunit assembly (GO:0000028)3.00479661
66viral transcription (GO:0019083)2.99119168
67interkinetic nuclear migration (GO:0022027)2.99101609
68phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.94845291
69regulation of histone H3-K4 methylation (GO:0051569)2.93859285
70exogenous drug catabolic process (GO:0042738)2.93472906
71regulation of fatty acid oxidation (GO:0046320)2.92327927
72regulation of nuclear cell cycle DNA replication (GO:0033262)2.91038492
73positive regulation of mitochondrial fission (GO:0090141)2.90006286
74regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.88134823
75cellular response to ATP (GO:0071318)2.88040996
76regulation of cilium movement (GO:0003352)2.87642000
77protein neddylation (GO:0045116)2.86819436
78carnitine metabolic process (GO:0009437)2.85523103
79regulation of mitochondrial fission (GO:0090140)2.84382085
80protein K48-linked deubiquitination (GO:0071108)2.83450781
81translational termination (GO:0006415)2.82964640
82tachykinin receptor signaling pathway (GO:0007217)2.82439768
83vesicle targeting (GO:0006903)2.82208118
84regulation of meiosis I (GO:0060631)2.81797511
85negative regulation of type I interferon production (GO:0032480)2.81764596
86somite development (GO:0061053)2.81236223
87DNA deamination (GO:0045006)2.81177885
88purine nucleobase biosynthetic process (GO:0009113)2.80734672
89photoreceptor cell maintenance (GO:0045494)2.80237058
90female gamete generation (GO:0007292)2.77917170
91protein complex biogenesis (GO:0070271)2.76388474
92positive regulation of guanylate cyclase activity (GO:0031284)2.74110814
93drug catabolic process (GO:0042737)2.71127358
94cellular ketone body metabolic process (GO:0046950)2.69727129
95ribosomal small subunit biogenesis (GO:0042274)2.69022952
96positive regulation of cell fate commitment (GO:0010455)2.65273190
97mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.64986373
98mitochondrial respiratory chain complex assembly (GO:0033108)2.64833569
99synaptonemal complex assembly (GO:0007130)2.64648504
100arginine catabolic process (GO:0006527)2.64184984

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.13384675
2MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.11056237
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.73453481
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.73163137
5VDR_22108803_ChIP-Seq_LS180_Human2.63588044
6GBX2_23144817_ChIP-Seq_PC3_Human2.51645950
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.48498377
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.48050988
9EWS_26573619_Chip-Seq_HEK293_Human2.42846278
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.41253368
11EZH2_22144423_ChIP-Seq_EOC_Human2.18398229
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.16228842
13FUS_26573619_Chip-Seq_HEK293_Human2.14152191
14ZNF274_21170338_ChIP-Seq_K562_Hela2.13480854
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.03112851
16MYC_18940864_ChIP-ChIP_HL60_Human1.98928725
17FLI1_27457419_Chip-Seq_LIVER_Mouse1.98918540
18ETV2_25802403_ChIP-Seq_MESCs_Mouse1.87535608
19EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.79600044
20TP53_22573176_ChIP-Seq_HFKS_Human1.74932904
21GATA1_26923725_Chip-Seq_HPCs_Mouse1.73294745
22CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.67682613
23EGR1_23403033_ChIP-Seq_LIVER_Mouse1.66681115
24MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.66533833
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61334502
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.59691408
27GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.59575777
28TAF15_26573619_Chip-Seq_HEK293_Human1.58272199
29FOXA1_27270436_Chip-Seq_PROSTATE_Human1.56348371
30FOXA1_25329375_ChIP-Seq_VCAP_Human1.56348371
31AR_20517297_ChIP-Seq_VCAP_Human1.55846622
32VDR_23849224_ChIP-Seq_CD4+_Human1.53380125
33P300_19829295_ChIP-Seq_ESCs_Human1.52253145
34ER_23166858_ChIP-Seq_MCF-7_Human1.50785553
35EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.49944171
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.49800709
37POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.49247689
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49247689
39HOXB7_26014856_ChIP-Seq_BT474_Human1.45016144
40WDR5_24793694_ChIP-Seq_LNCAP_Human1.43729635
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41854521
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39869434
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38024238
44FOXH1_21741376_ChIP-Seq_EPCs_Human1.37518263
45CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.35617248
46TCF4_23295773_ChIP-Seq_U87_Human1.34400091
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34123606
48GATA3_21878914_ChIP-Seq_MCF-7_Human1.34076664
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33733216
50NANOG_20526341_ChIP-Seq_ESCs_Human1.32951010
51PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.30177836
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29499999
53FOXP3_21729870_ChIP-Seq_TREG_Human1.26792005
54ERA_21632823_ChIP-Seq_H3396_Human1.26015136
55REST_21632747_ChIP-Seq_MESCs_Mouse1.25268116
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25205780
57CBP_20019798_ChIP-Seq_JUKART_Human1.25205780
58RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.22222895
59FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.21375699
60DROSHA_22980978_ChIP-Seq_HELA_Human1.19834875
61P53_21459846_ChIP-Seq_SAOS-2_Human1.17099819
62FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16413183
63RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.15584982
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14353369
65RBPJ_21746931_ChIP-Seq_IB4_Human1.12863242
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12521525
67CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.09963268
68JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.09310159
69TAF2_19829295_ChIP-Seq_ESCs_Human1.09013389
70AR_21572438_ChIP-Seq_LNCaP_Human1.08955916
71CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.08617824
72NCOR_22424771_ChIP-Seq_293T_Human1.08122134
73DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07891625
74ETS1_20019798_ChIP-Seq_JURKAT_Human1.07794383
75SMAD4_21741376_ChIP-Seq_EPCs_Human1.06580067
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05341324
77EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.04622242
78AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03878995
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03736831
80MYC_19829295_ChIP-Seq_ESCs_Human1.01938260
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01652539
82NANOG_19829295_ChIP-Seq_ESCs_Human0.99934278
83SOX2_19829295_ChIP-Seq_ESCs_Human0.99934278
84BCAT_22108803_ChIP-Seq_LS180_Human0.99704519
85KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98549792
86LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98338538
87SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97956468
88ETV1_20927104_ChIP-Seq_GIST48_Human0.97437060
89PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96956934
90STAT3_23295773_ChIP-Seq_U87_Human0.96547393
91OCT1_27270436_Chip-Seq_PROSTATE_Human0.95434207
92CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.93567897
93PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93148524
94SMAD3_21741376_ChIP-Seq_ESCs_Human0.92609496
95RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92497759
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91760066
97CDX2_22108803_ChIP-Seq_LS180_Human0.89956349
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89413452
99NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89222829
100TCF4_18268006_ChIP-ChIP_LS174T_Human0.88958091

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.60505017
2MP0009780_abnormal_chondrocyte_physiolo3.24048597
3MP0003646_muscle_fatigue2.96251730
4MP0006072_abnormal_retinal_apoptosis2.90908742
5MP0005085_abnormal_gallbladder_physiolo2.54547363
6MP0005310_abnormal_salivary_gland2.52481509
7MP0005646_abnormal_pituitary_gland2.51150698
8MP0004885_abnormal_endolymph2.34733140
9MP0009379_abnormal_foot_pigmentation2.34475732
10MP0002876_abnormal_thyroid_physiology2.30507807
11MP0008875_abnormal_xenobiotic_pharmacok2.21241719
12MP0008872_abnormal_physiological_respon2.19021693
13MP0006292_abnormal_olfactory_placode2.10163440
14MP0003122_maternal_imprinting1.99851692
15MP0003011_delayed_dark_adaptation1.95824428
16MP0005377_hearing/vestibular/ear_phenot1.90452917
17MP0003878_abnormal_ear_physiology1.90452917
18MP0002163_abnormal_gland_morphology1.85977769
19MP0005551_abnormal_eye_electrophysiolog1.82861692
20MP0008877_abnormal_DNA_methylation1.75533712
21MP0000372_irregular_coat_pigmentation1.74226753
22MP0004742_abnormal_vestibular_system1.71155133
23MP0009764_decreased_sensitivity_to1.68714534
24MP0003879_abnormal_hair_cell1.67871512
25MP0004484_altered_response_of1.63348773
26MP0005645_abnormal_hypothalamus_physiol1.62566552
27MP0002138_abnormal_hepatobiliary_system1.62472400
28MP0001968_abnormal_touch/_nociception1.62455914
29MP0003718_maternal_effect1.62139898
30MP0003195_calcinosis1.60424094
31MP0009745_abnormal_behavioral_response1.56834513
32MP0000631_abnormal_neuroendocrine_gland1.56297048
33MP0005360_urolithiasis1.54096312
34MP0001485_abnormal_pinna_reflex1.53014320
35MP0005408_hypopigmentation1.50833320
36MP0005253_abnormal_eye_physiology1.49568707
37MP0004142_abnormal_muscle_tone1.49260740
38MP0005365_abnormal_bile_salt1.45732009
39MP0008775_abnormal_heart_ventricle1.44582602
40MP0004043_abnormal_pH_regulation1.39008326
41MP0005332_abnormal_amino_acid1.38356300
42MP0006276_abnormal_autonomic_nervous1.36799555
43MP0002938_white_spotting1.36248059
44MP0001986_abnormal_taste_sensitivity1.35534642
45MP0002693_abnormal_pancreas_physiology1.34833089
46MP0003787_abnormal_imprinting1.34721287
47MP0009643_abnormal_urine_homeostasis1.31111225
48MP0002557_abnormal_social/conspecific_i1.30108011
49MP0002272_abnormal_nervous_system1.26408567
50MP0001501_abnormal_sleep_pattern1.25284096
51MP0005167_abnormal_blood-brain_barrier1.25051149
52MP0002735_abnormal_chemical_nociception1.24136350
53MP0002837_dystrophic_cardiac_calcinosis1.22527529
54MP0001970_abnormal_pain_threshold1.20626565
55MP0002638_abnormal_pupillary_reflex1.20563447
56MP0001756_abnormal_urination1.19265642
57MP0002736_abnormal_nociception_after1.19134731
58MP0003938_abnormal_ear_development1.12005657
59MP0002928_abnormal_bile_duct1.11386575
60MP0005379_endocrine/exocrine_gland_phen1.07844631
61MP0000230_abnormal_systemic_arterial1.04645220
62MP0001873_stomach_inflammation1.03188970
63MP0005410_abnormal_fertilization1.03021522
64MP0001348_abnormal_lacrimal_gland1.02718918
65MP0001502_abnormal_circadian_rhythm1.01475518
66MP0002733_abnormal_thermal_nociception0.98461627
67MP0000026_abnormal_inner_ear0.97901687
68MP0004381_abnormal_hair_follicle0.97871982
69MP0005084_abnormal_gallbladder_morpholo0.97366436
70MP0003121_genomic_imprinting0.96906340
71MP0010386_abnormal_urinary_bladder0.96903092
72MP0001666_abnormal_nutrient_absorption0.96884207
73MP0002210_abnormal_sex_determination0.96318448
74MP0004133_heterotaxia0.95953542
75MP0004215_abnormal_myocardial_fiber0.93524376
76MP0000427_abnormal_hair_cycle0.92394556
77MP0003880_abnormal_central_pattern0.90506224
78MP0002064_seizures0.90352448
79MP0002102_abnormal_ear_morphology0.90302636
80MP0003638_abnormal_response/metabolism_0.90166910
81MP0003567_abnormal_fetal_cardiomyocyte0.88227753
82MP0005174_abnormal_tail_pigmentation0.87561494
83MP0005195_abnormal_posterior_eye0.86004619
84MP0006036_abnormal_mitochondrial_physio0.85308140
85MP0004130_abnormal_muscle_cell0.83868315
86MP0005448_abnormal_energy_balance0.83647032
87MP0002572_abnormal_emotion/affect_behav0.82682393
88MP0001963_abnormal_hearing_physiology0.82626356
89MP0001764_abnormal_homeostasis0.82246929
90MP0002653_abnormal_ependyma_morphology0.81016649
91MP0009046_muscle_twitch0.80559814
92MP0002136_abnormal_kidney_physiology0.80131484
93MP0003937_abnormal_limbs/digits/tail_de0.79183730
94MP0001324_abnormal_eye_pigmentation0.79049333
95MP0003635_abnormal_synaptic_transmissio0.77929792
96MP0002095_abnormal_skin_pigmentation0.75377777
97MP0002909_abnormal_adrenal_gland0.75369612
98MP0002063_abnormal_learning/memory/cond0.75367730
99MP0003698_abnormal_male_reproductive0.75294491
100MP0010329_abnormal_lipoprotein_level0.74042308

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)4.30707572
2Abnormal rod and cone electroretinograms (HP:0008323)3.88976166
3Absent rod-and cone-mediated responses on ERG (HP:0007688)3.87070681
4Pancreatic cysts (HP:0001737)3.82145648
5Chronic bronchitis (HP:0004469)3.65622517
6Molar tooth sign on MRI (HP:0002419)3.48952617
7Abnormality of midbrain morphology (HP:0002418)3.48952617
8Reticulocytopenia (HP:0001896)3.41210206
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.34899461
10Cerebellar dysplasia (HP:0007033)3.33153584
11Tubular atrophy (HP:0000092)3.30770115
12Pigmentary retinal degeneration (HP:0001146)3.30139551
13Decreased circulating renin level (HP:0003351)3.24697687
14Pancreatic fibrosis (HP:0100732)3.20381844
15Lipid accumulation in hepatocytes (HP:0006561)3.18502852
16Bile duct proliferation (HP:0001408)3.05950909
17Abnormal biliary tract physiology (HP:0012439)3.05950909
18True hermaphroditism (HP:0010459)3.03030042
19Attenuation of retinal blood vessels (HP:0007843)3.00371953
20Congenital stationary night blindness (HP:0007642)2.99426338
21Polydipsia (HP:0001959)2.89925472
22Abnormal drinking behavior (HP:0030082)2.89925472
23Hypoplasia of the pons (HP:0012110)2.88705835
24Bony spicule pigmentary retinopathy (HP:0007737)2.82804239
25Nephronophthisis (HP:0000090)2.81141192
26Abnormality of the renal cortex (HP:0011035)2.80985250
27Thyroid-stimulating hormone excess (HP:0002925)2.74635974
28Acute necrotizing encephalopathy (HP:0006965)2.69112659
29Increased hepatocellular lipid droplets (HP:0006565)2.63130489
30Abnormality of the pons (HP:0007361)2.59412683
31Decreased central vision (HP:0007663)2.58606144
32Acute encephalopathy (HP:0006846)2.54616295
33Conical tooth (HP:0000698)2.51709135
34Rimmed vacuoles (HP:0003805)2.51025276
35Increased CSF lactate (HP:0002490)2.44078449
36Hypokalemic alkalosis (HP:0001949)2.43242122
37Polyuria (HP:0000103)2.43102468
38Abnormality of cells of the erythroid lineage (HP:0012130)2.41074880
39Mitochondrial inheritance (HP:0001427)2.35522957
40Choroideremia (HP:0001139)2.33114840
41Absent thumb (HP:0009777)2.32445860
42Aplasia/Hypoplasia of the spleen (HP:0010451)2.32436350
43Abnormality of the renal medulla (HP:0100957)2.32391484
443-Methylglutaconic aciduria (HP:0003535)2.31604523
45Concave nail (HP:0001598)2.31151640
46Abnormal respiratory motile cilium physiology (HP:0012261)2.28142004
47Abnormal mitochondria in muscle tissue (HP:0008316)2.25859365
48Asplenia (HP:0001746)2.24300285
49Flat occiput (HP:0005469)2.24078656
50Abnormality of renin-angiotensin system (HP:0000847)2.22123946
51Methylmalonic acidemia (HP:0002912)2.15346833
52Hyperactive renin-angiotensin system (HP:0000841)2.13578766
53Respiratory difficulties (HP:0002880)2.12096436
54Hyperglycinemia (HP:0002154)2.09628402
55Delayed CNS myelination (HP:0002188)2.07554085
56Increased serum lactate (HP:0002151)2.06903139
57Medial flaring of the eyebrow (HP:0010747)2.06822308
58Chronic hepatic failure (HP:0100626)2.06782929
59Progressive macrocephaly (HP:0004481)2.04826202
60Renal cortical cysts (HP:0000803)2.03973771
61Cystic liver disease (HP:0006706)2.02618226
62Methylmalonic aciduria (HP:0012120)2.02430802
63Retinitis pigmentosa (HP:0000510)2.00479923
64Renal Fanconi syndrome (HP:0001994)2.00020578
65Supernumerary spleens (HP:0009799)1.99731586
66Abnormal urine output (HP:0012590)1.96492383
67Retinal dysplasia (HP:0007973)1.94446755
68Agitation (HP:0000713)1.93620607
69Optic disc pallor (HP:0000543)1.91737221
70Hyperaldosteronism (HP:0000859)1.91712556
71Meckel diverticulum (HP:0002245)1.90111991
72Severe Myopia (HP:0011003)1.90073162
73Congenital hepatic fibrosis (HP:0002612)1.89802525
74Renal salt wasting (HP:0000127)1.88024752
75Hyperkalemia (HP:0002153)1.85882269
76Aplasia/Hypoplasia of the uvula (HP:0010293)1.84849568
77Abnormality of the ileum (HP:0001549)1.84764137
78Tachypnea (HP:0002789)1.84668123
79Abnormality of alanine metabolism (HP:0010916)1.84370753
80Hyperalaninemia (HP:0003348)1.84370753
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84370753
82Abnormality of urine glucose concentration (HP:0011016)1.83799444
83Glycosuria (HP:0003076)1.83799444
84Focal seizures (HP:0007359)1.83290262
85Septo-optic dysplasia (HP:0100842)1.82040421
86Abnormal number of erythroid precursors (HP:0012131)1.80817877
87Macrocytic anemia (HP:0001972)1.80489724
88Hepatocellular necrosis (HP:0001404)1.79777922
89Horseshoe kidney (HP:0000085)1.78054079
90Lissencephaly (HP:0001339)1.77297059
91Anencephaly (HP:0002323)1.75587992
92Bronchiectasis (HP:0002110)1.74881110
93Sleep apnea (HP:0010535)1.72942591
94Abnormality of renal excretion (HP:0011036)1.72800478
95Sclerocornea (HP:0000647)1.72535956
96Postaxial foot polydactyly (HP:0001830)1.72442891
97Metabolic acidosis (HP:0001942)1.71310330
98Microvesicular hepatic steatosis (HP:0001414)1.70943539
99Colon cancer (HP:0003003)1.70528806
100Gait imbalance (HP:0002141)1.69339276

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK6.53623177
2FRK4.22636951
3CAMKK24.05934360
4MAP3K93.73711513
5CAMK1D3.39685698
6DYRK22.20865179
7CAMK1G2.20314736
8ADRBK22.20294399
9WNK42.19173069
10TXK2.04139341
11MAP4K22.01224847
12NUAK11.97553952
13GRK11.87225412
14ZAK1.83330503
15PINK11.70511871
16OXSR11.64995428
17MST41.59970269
18CAMKK11.59671003
19DAPK21.55748304
20CAMK41.42764893
21BCKDK1.36608574
22PDK11.34814797
23STK161.30857590
24STK391.30749074
25MKNK21.28135875
26TLK11.26533758
27PDPK11.24859721
28MAP2K61.12115150
29WNK11.01668588
30EPHA41.00612426
31CAMK11.00310168
32STK38L0.97794903
33EPHA30.96172062
34TNK20.95893429
35CSNK1E0.91669378
36CDK190.89840682
37PRKCG0.87856369
38CASK0.87391570
39WNK30.87218433
40NEK10.86885536
41PRKCE0.86278858
42TYRO30.84517034
43ADRBK10.83392229
44ITK0.82807374
45HIPK20.81154313
46TNIK0.79782878
47MAPKAPK50.78539524
48VRK10.78482607
49PIK3CA0.77225885
50BMPR1B0.73539621
51PRKCI0.72897301
52SRPK10.69573743
53ERBB20.68229419
54VRK20.67832776
55IKBKB0.67653892
56MKNK10.63848095
57RPS6KA60.63696286
58TAF10.62310503
59NME10.61965074
60PASK0.61894954
61CDK90.61400661
62MARK10.61276389
63PRKCH0.60421480
64ACVR1B0.59557810
65PAK30.59187128
66STK110.57760290
67TSSK60.57652267
68PRKCQ0.57045527
69MAP3K40.56687100
70INSRR0.55968929
71CSNK2A20.52462132
72DYRK30.51710919
73NEK20.51088694
74CAMK2A0.50286328
75STK30.50221291
76RPS6KA50.48437918
77CSNK1A10.48225195
78TIE10.46477179
79RPS6KA40.46197667
80PLK10.45461394
81MARK30.43763983
82PLK40.42612376
83RPS6KC10.40034585
84RPS6KL10.40034585
85ATR0.37512352
86PRKACA0.36218852
87PRKCA0.35113402
88MAPK130.35017799
89BUB10.34974052
90GSK3A0.34768431
91MAP2K70.34648059
92PRKG10.33988369
93PRKCZ0.33950203
94SGK10.33850154
95LATS10.32995964
96NTRK20.32140283
97KIT0.31828919
98LYN0.31692691
99AURKB0.31573589
100PIK3CG0.29116536

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002323.17715898
2Linoleic acid metabolism_Homo sapiens_hsa005913.15770162
3Propanoate metabolism_Homo sapiens_hsa006402.88058452
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.76316158
5Ribosome_Homo sapiens_hsa030102.75530806
6One carbon pool by folate_Homo sapiens_hsa006702.65449114
7Regulation of autophagy_Homo sapiens_hsa041402.61360070
8Oxidative phosphorylation_Homo sapiens_hsa001902.45172835
9RNA polymerase_Homo sapiens_hsa030202.11435183
10Tryptophan metabolism_Homo sapiens_hsa003802.08993976
11Sulfur metabolism_Homo sapiens_hsa009201.97324706
12Ether lipid metabolism_Homo sapiens_hsa005651.77683610
13Parkinsons disease_Homo sapiens_hsa050121.72813975
14RNA degradation_Homo sapiens_hsa030181.63161966
15Sulfur relay system_Homo sapiens_hsa041221.62368813
16Asthma_Homo sapiens_hsa053101.62128091
17Cysteine and methionine metabolism_Homo sapiens_hsa002701.60841878
18Pyruvate metabolism_Homo sapiens_hsa006201.58623230
19Cardiac muscle contraction_Homo sapiens_hsa042601.58237732
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57237951
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.55620807
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.55482171
23Proteasome_Homo sapiens_hsa030501.55350328
24Fatty acid degradation_Homo sapiens_hsa000711.55125841
25Phototransduction_Homo sapiens_hsa047441.52282744
26Huntingtons disease_Homo sapiens_hsa050161.45322090
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.42975212
28Selenocompound metabolism_Homo sapiens_hsa004501.36939065
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.31976592
30Basal transcription factors_Homo sapiens_hsa030221.29181582
31Arachidonic acid metabolism_Homo sapiens_hsa005901.23686922
32Mismatch repair_Homo sapiens_hsa034301.23604888
33Fat digestion and absorption_Homo sapiens_hsa049751.23045064
34Homologous recombination_Homo sapiens_hsa034401.21782393
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.18772182
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17097905
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16265140
38Butanoate metabolism_Homo sapiens_hsa006501.14145634
39Alzheimers disease_Homo sapiens_hsa050101.09896963
40Nicotine addiction_Homo sapiens_hsa050331.08235205
41Nitrogen metabolism_Homo sapiens_hsa009101.06178714
42Allograft rejection_Homo sapiens_hsa053301.05349747
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.02911020
44Ovarian steroidogenesis_Homo sapiens_hsa049131.02609289
45Autoimmune thyroid disease_Homo sapiens_hsa053200.99059927
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98734012
47Primary bile acid biosynthesis_Homo sapiens_hsa001200.98365922
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.98236809
49Arginine and proline metabolism_Homo sapiens_hsa003300.95268058
50Chemical carcinogenesis_Homo sapiens_hsa052040.94242499
51Fanconi anemia pathway_Homo sapiens_hsa034600.93981895
52Insulin secretion_Homo sapiens_hsa049110.91402986
53Retinol metabolism_Homo sapiens_hsa008300.91304979
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.90023422
55Morphine addiction_Homo sapiens_hsa050320.89498722
56Fatty acid metabolism_Homo sapiens_hsa012120.88814380
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88548795
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88301421
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87705871
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85988344
61Taste transduction_Homo sapiens_hsa047420.85203605
62Purine metabolism_Homo sapiens_hsa002300.84283211
63Steroid biosynthesis_Homo sapiens_hsa001000.83199880
64Protein export_Homo sapiens_hsa030600.82537222
65Pyrimidine metabolism_Homo sapiens_hsa002400.82053941
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81930810
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75480194
68Metabolic pathways_Homo sapiens_hsa011000.74936569
69Lysine degradation_Homo sapiens_hsa003100.74216387
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73622668
71Peroxisome_Homo sapiens_hsa041460.72005578
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70496213
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70441044
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70173062
75Olfactory transduction_Homo sapiens_hsa047400.67513758
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65729024
77Glycerolipid metabolism_Homo sapiens_hsa005610.65076116
78Salivary secretion_Homo sapiens_hsa049700.65035839
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64664264
80Vitamin digestion and absorption_Homo sapiens_hsa049770.61987657
81Arginine biosynthesis_Homo sapiens_hsa002200.57443049
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53761252
83RNA transport_Homo sapiens_hsa030130.52888059
84Primary immunodeficiency_Homo sapiens_hsa053400.51881404
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50921805
86Mineral absorption_Homo sapiens_hsa049780.48492589
87Starch and sucrose metabolism_Homo sapiens_hsa005000.44515591
88Staphylococcus aureus infection_Homo sapiens_hsa051500.42575450
89Glutamatergic synapse_Homo sapiens_hsa047240.42447951
90Serotonergic synapse_Homo sapiens_hsa047260.41034166
91PPAR signaling pathway_Homo sapiens_hsa033200.40958858
92Pancreatic secretion_Homo sapiens_hsa049720.40073738
93Fatty acid biosynthesis_Homo sapiens_hsa000610.39832075
94Histidine metabolism_Homo sapiens_hsa003400.37152612
95beta-Alanine metabolism_Homo sapiens_hsa004100.35837610
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35765828
97Circadian rhythm_Homo sapiens_hsa047100.35712799
98Thyroid hormone synthesis_Homo sapiens_hsa049180.35142030
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.34734377
100Glucagon signaling pathway_Homo sapiens_hsa049220.34722368

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