ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	7.51961829
2	translational termination (GO:0006415)	7.19164189
3	maturation of SSU-rRNA (GO:0030490)	6.88915155
4	ribosomal small subunit assembly (GO:0000028)	6.57102932
5	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.16975337
6	translational elongation (GO:0006414)	6.10739196
7	cotranslational protein targeting to membrane (GO:0006613)	6.05081016
8	protein targeting to ER (GO:0045047)	6.00622097
9	ribosomal small subunit biogenesis (GO:0042274)	5.84909511
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.75327596
11	protein localization to endoplasmic reticulum (GO:0070972)	5.68978196
12	DNA deamination (GO:0045006)	5.56378512
13	chaperone-mediated protein transport (GO:0072321)	5.49135728
14	cellular protein complex disassembly (GO:0043624)	5.38827922
15	viral life cycle (GO:0019058)	5.37369014
16	ATP synthesis coupled proton transport (GO:0015986)	5.11711303
17	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.11711303
18	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.06847892
19	ribosomal large subunit biogenesis (GO:0042273)	5.03955935
20	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.93252445
21	translational initiation (GO:0006413)	4.73228525
22	protein complex disassembly (GO:0043241)	4.47187389
23	protein neddylation (GO:0045116)	4.30693380
24	macromolecular complex disassembly (GO:0032984)	4.24174526
25	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.99173373
26	translation (GO:0006412)	3.99125676
27	protein targeting to membrane (GO:0006612)	3.90552425
28	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.87201281
29	water-soluble vitamin biosynthetic process (GO:0042364)	3.85356828
30	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.83425211
31	behavioral response to nicotine (GO:0035095)	3.82085550
32	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.70841314
33	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.70317594
34	NADH dehydrogenase complex assembly (GO:0010257)	3.70317594
35	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.70317594
36	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.63437459
37	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.63437459
38	protein complex biogenesis (GO:0070271)	3.62722352
39	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.58420874
40	GTP biosynthetic process (GO:0006183)	3.37814754
41	ribonucleoprotein complex biogenesis (GO:0022613)	3.36371429
42	mRNA catabolic process (GO:0006402)	3.34058147
43	base-excision repair, AP site formation (GO:0006285)	3.29476792
44	cellular component biogenesis (GO:0044085)	3.27601845
45	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.25010535
46	cytidine metabolic process (GO:0046087)	3.22236034
47	cytidine catabolic process (GO:0006216)	3.22236034
48	cytidine deamination (GO:0009972)	3.22236034
49	mitochondrial respiratory chain complex assembly (GO:0033108)	3.21586493
50	cellular anion homeostasis (GO:0030002)	3.21369989
51	electron transport chain (GO:0022900)	3.21084715
52	ATP biosynthetic process (GO:0006754)	3.20967098
53	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.19951133
54	respiratory electron transport chain (GO:0022904)	3.19459240
55	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.19110206
56	pyrimidine nucleotide catabolic process (GO:0006244)	3.17091687
57	kynurenine metabolic process (GO:0070189)	3.12569251
58	male meiosis I (GO:0007141)	2.96513458
59	ubiquinone biosynthetic process (GO:0006744)	2.93593525
60	respiratory chain complex IV assembly (GO:0008535)	2.92632219
61	regulation of isotype switching to IgG isotypes (GO:0048302)	2.92533313
62	RNA catabolic process (GO:0006401)	2.92456505
63	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.89981237
64	tryptophan catabolic process (GO:0006569)	2.84169359
65	indole-containing compound catabolic process (GO:0042436)	2.84169359
66	indolalkylamine catabolic process (GO:0046218)	2.84169359
67	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.83332768
68	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.81579801
69	aldehyde catabolic process (GO:0046185)	2.81488383
70	cell proliferation in forebrain (GO:0021846)	2.81398970
71	rRNA processing (GO:0006364)	2.80329017
72	UTP biosynthetic process (GO:0006228)	2.76331402
73	dopamine transport (GO:0015872)	2.75052171
74	cytochrome complex assembly (GO:0017004)	2.72707378
75	positive regulation of fatty acid transport (GO:2000193)	2.72697909
76	phosphatidylcholine acyl-chain remodeling (GO:0036151)	2.72087474
77	rRNA metabolic process (GO:0016072)	2.71715239
78	intra-S DNA damage checkpoint (GO:0031573)	2.70391750
79	deoxyribonucleotide catabolic process (GO:0009264)	2.68064915
80	positive regulation of icosanoid secretion (GO:0032305)	2.67583073
81	positive regulation of cell fate commitment (GO:0010455)	2.66926183
82	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.65633924
83	establishment of protein localization to membrane (GO:0090150)	2.65067549
84	ubiquinone metabolic process (GO:0006743)	2.64827984
85	deoxyribose phosphate catabolic process (GO:0046386)	2.62139996
86	preassembly of GPI anchor in ER membrane (GO:0016254)	2.59498295
87	hydrogen ion transmembrane transport (GO:1902600)	2.59489414
88	indolalkylamine metabolic process (GO:0006586)	2.55261797
89	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.55155124
90	UTP metabolic process (GO:0046051)	2.53478359
91	protein targeting (GO:0006605)	2.53348876
92	synapsis (GO:0007129)	2.52508059
93	regulation of mesoderm development (GO:2000380)	2.52481364
94	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.52465703
95	parturition (GO:0007567)	2.49101218
96	maturation of 5.8S rRNA (GO:0000460)	2.48992616
97	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.48421077
98	piRNA metabolic process (GO:0034587)	2.48079083
99	L-fucose metabolic process (GO:0042354)	2.44518633
100	L-fucose catabolic process (GO:0042355)	2.44518633

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.29955241
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.26415683
3	VDR_22108803_ChIP-Seq_LS180_Human	3.19189584
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.18921477
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.87730718
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.67384115
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.65174229
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.60734811
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.45874612
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.38257903
11	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.37681922
12	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.15038435
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.08297047
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.05038572
15	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.03314845
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.00398922
17	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.99027918
18	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.90916695
19	MYC_18940864_ChIP-ChIP_HL60_Human	1.86563095
20	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.86082449
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.80651838
22	TP53_22573176_ChIP-Seq_HFKS_Human	1.78320732
23	IRF1_19129219_ChIP-ChIP_H3396_Human	1.67755765
24	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.66764538
25	EWS_26573619_Chip-Seq_HEK293_Human	1.55805021
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.55627715
27	ELK1_19687146_ChIP-ChIP_HELA_Human	1.52521185
28	FUS_26573619_Chip-Seq_HEK293_Human	1.50751836
29	TAF2_19829295_ChIP-Seq_ESCs_Human	1.49743288
30	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.49705274
31	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.48609203
32	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.48492320
33	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.48481247
34	AR_20517297_ChIP-Seq_VCAP_Human	1.46243389
35	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.43387119
36	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.43067248
37	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.42677283
38	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.41587444
39	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.41057120
40	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.36591204
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.36591204
42	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.35566523
43	IGF1R_20145208_ChIP-Seq_DFB_Human	1.35124384
44	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.34980372
45	NCOR_22424771_ChIP-Seq_293T_Human	1.33785482
46	P300_19829295_ChIP-Seq_ESCs_Human	1.32374189
47	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.31366646
48	NANOG_20526341_ChIP-Seq_ESCs_Human	1.30317333
49	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.29794667
50	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.29376830
51	FOXP3_21729870_ChIP-Seq_TREG_Human	1.28742990
52	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.27631022
53	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.24382878
54	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.23041755
55	TTF2_22483619_ChIP-Seq_HELA_Human	1.20261426
56	MYC_19829295_ChIP-Seq_ESCs_Human	1.19103236
57	RNF2_27304074_Chip-Seq_NSC_Mouse	1.19100329
58	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.17842854
59	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.17710910
60	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.16496446
61	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.15668923
62	ERG_20517297_ChIP-Seq_VCAP_Human	1.15428475
63	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.14915531
64	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.14457583
65	NANOG_19829295_ChIP-Seq_ESCs_Human	1.14218710
66	SOX2_19829295_ChIP-Seq_ESCs_Human	1.14218710
67	ER_23166858_ChIP-Seq_MCF-7_Human	1.14101099
68	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.11161141
69	P53_21459846_ChIP-Seq_SAOS-2_Human	1.10778614
70	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.10743205
71	ERA_21632823_ChIP-Seq_H3396_Human	1.10360818
72	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.09080035
73	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.07974038
74	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.06816340
75	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.06522465
76	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.03383590
77	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.03330002
78	CBP_20019798_ChIP-Seq_JUKART_Human	1.03330002
79	GATA3_26560356_Chip-Seq_TH2_Human	1.02490337
80	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.02186520
81	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.99923572
82	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.99758963
83	OCT4_20526341_ChIP-Seq_ESCs_Human	0.98889594
84	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.98657081
85	HOXB7_26014856_ChIP-Seq_BT474_Human	0.98051749
86	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.97943577
87	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.97769576
88	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.95858736
89	REST_21632747_ChIP-Seq_MESCs_Mouse	0.95188744
90	GBX2_23144817_ChIP-Seq_PC3_Human	0.94441554
91	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.94022723
92	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.93957260
93	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.92843584
94	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.92817063
95	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.92608406
96	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.91948580
97	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.91017824
98	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.89986831
99	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.89784024
100	GABP_19822575_ChIP-Seq_HepG2_Human	0.89372226

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.55317015
2	MP0006292_abnormal_olfactory_placode	4.46517994
3	MP0002653_abnormal_ependyma_morphology	3.41184625
4	MP0002837_dystrophic_cardiac_calcinosis	2.65215388
5	MP0002234_abnormal_pharynx_morphology	2.53291130
6	MP0002163_abnormal_gland_morphology	2.52071674
7	MP0001835_abnormal_antigen_presentation	2.34130745
8	MP0001986_abnormal_taste_sensitivity	2.27171219
9	MP0002102_abnormal_ear_morphology	2.21022983
10	MP0003195_calcinosis	2.05365119
11	MP0008875_abnormal_xenobiotic_pharmacok	1.98994121
12	MP0004145_abnormal_muscle_electrophysio	1.97726260
13	MP0005671_abnormal_response_to	1.94223896
14	MP0004142_abnormal_muscle_tone	1.93529311
15	MP0003646_muscle_fatigue	1.92071495
16	MP0003011_delayed_dark_adaptation	1.90786336
17	MP0008789_abnormal_olfactory_epithelium	1.89581622
18	MP0001873_stomach_inflammation	1.81187715
19	MP0008877_abnormal_DNA_methylation	1.81034792
20	MP0008872_abnormal_physiological_respon	1.74723855
21	MP0005646_abnormal_pituitary_gland	1.74105491
22	MP0002160_abnormal_reproductive_system	1.70062970
23	MP0005551_abnormal_eye_electrophysiolog	1.69603482
24	MP0003878_abnormal_ear_physiology	1.67386329
25	MP0005377_hearing/vestibular/ear_phenot	1.67386329
26	MP0006072_abnormal_retinal_apoptosis	1.66628691
27	MP0001529_abnormal_vocalization	1.61571265
28	MP0005379_endocrine/exocrine_gland_phen	1.59379575
29	MP0003787_abnormal_imprinting	1.58149960
30	MP0005389_reproductive_system_phenotype	1.56131861
31	MP0004885_abnormal_endolymph	1.53381713
32	MP0005394_taste/olfaction_phenotype	1.47185079
33	MP0005499_abnormal_olfactory_system	1.47185079
34	MP0006276_abnormal_autonomic_nervous	1.45108824
35	MP0004147_increased_porphyrin_level	1.43626431
36	MP0002876_abnormal_thyroid_physiology	1.38179529
37	MP0002938_white_spotting	1.35701478
38	MP0001968_abnormal_touch/_nociception	1.33511199
39	MP0002736_abnormal_nociception_after	1.33380368
40	MP0001293_anophthalmia	1.31351292
41	MP0000049_abnormal_middle_ear	1.29744330
42	MP0006054_spinal_hemorrhage	1.28563020
43	MP0003122_maternal_imprinting	1.28401325
44	MP0004782_abnormal_surfactant_physiolog	1.24501741
45	MP0002138_abnormal_hepatobiliary_system	1.24288182
46	MP0005645_abnormal_hypothalamus_physiol	1.21671717
47	MP0001905_abnormal_dopamine_level	1.17845594
48	MP0002095_abnormal_skin_pigmentation	1.15976803
49	MP0001919_abnormal_reproductive_system	1.15211152
50	MP0001440_abnormal_grooming_behavior	1.14183502
51	MP0009745_abnormal_behavioral_response	1.13574020
52	MP0002272_abnormal_nervous_system	1.13321730
53	MP0000631_abnormal_neuroendocrine_gland	1.12971487
54	MP0009785_altered_susceptibility_to	1.11049012
55	MP0001485_abnormal_pinna_reflex	1.10085220
56	MP0003567_abnormal_fetal_cardiomyocyte	1.09536122
57	MP0003186_abnormal_redox_activity	1.08904118
58	MP0001800_abnormal_humoral_immune	1.08000845
59	MP0003880_abnormal_central_pattern	1.07840789
60	MP0001348_abnormal_lacrimal_gland	1.06784271
61	MP0001764_abnormal_homeostasis	1.05749716
62	MP0000372_irregular_coat_pigmentation	1.04878554
63	MP0005253_abnormal_eye_physiology	1.02051794
64	MP0001663_abnormal_digestive_system	0.97311407
65	MP0002733_abnormal_thermal_nociception	0.95514509
66	MP0001970_abnormal_pain_threshold	0.94413035
67	MP0005423_abnormal_somatic_nervous	0.93393776
68	MP0009764_decreased_sensitivity_to	0.90453372
69	MP0008775_abnormal_heart_ventricle	0.89625620
70	MP0009046_muscle_twitch	0.85523544
71	MP0003879_abnormal_hair_cell	0.84474782
72	MP0005174_abnormal_tail_pigmentation	0.82823845
73	MP0009333_abnormal_splenocyte_physiolog	0.82428312
74	MP0002638_abnormal_pupillary_reflex	0.81962599
75	MP0004130_abnormal_muscle_cell	0.81299980
76	MP0004742_abnormal_vestibular_system	0.80945629
77	MP0002693_abnormal_pancreas_physiology	0.80697268
78	MP0002723_abnormal_immune_serum	0.78451615
79	MP0002148_abnormal_hypersensitivity_rea	0.76378700
80	MP0005195_abnormal_posterior_eye	0.75486311
81	MP0005084_abnormal_gallbladder_morpholo	0.75183217
82	MP0002557_abnormal_social/conspecific_i	0.74760505
83	MP0001486_abnormal_startle_reflex	0.74506371
84	MP0001664_abnormal_digestion	0.71516492
85	MP0000026_abnormal_inner_ear	0.71486278
86	MP0000569_abnormal_digit_pigmentation	0.70238746
87	MP0003121_genomic_imprinting	0.69924501
88	MP0005381_digestive/alimentary_phenotyp	0.69120793
89	MP0002735_abnormal_chemical_nociception	0.68842602
90	MP0002734_abnormal_mechanical_nocicepti	0.68224312
91	MP0001501_abnormal_sleep_pattern	0.67741671
92	MP0004043_abnormal_pH_regulation	0.67330145
93	MP0002752_abnormal_somatic_nervous	0.66753345
94	MP0005075_abnormal_melanosome_morpholog	0.66344930
95	MP0001119_abnormal_female_reproductive	0.65919007
96	MP0003936_abnormal_reproductive_system	0.65376955
97	MP0006036_abnormal_mitochondrial_physio	0.64842455
98	MP0002210_abnormal_sex_determination	0.64464421
99	MP0005410_abnormal_fertilization	0.64260038
100	MP0001790_abnormal_immune_system	0.63737646

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chronic otitis media (HP:0000389)	4.21952389
2	Acute necrotizing encephalopathy (HP:0006965)	4.08199600
3	Abnormality of cells of the erythroid lineage (HP:0012130)	3.84346551
4	Chronic sinusitis (HP:0011109)	3.68661119
5	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.64397716
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.63531406
7	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.62101022
8	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.62101022
9	Acute encephalopathy (HP:0006846)	3.51483424
10	Reticulocytopenia (HP:0001896)	3.50793707
11	Macrocytic anemia (HP:0001972)	3.47659562
12	Abnormal number of erythroid precursors (HP:0012131)	3.47482234
13	Mitochondrial inheritance (HP:0001427)	3.46485444
14	Pancreatic fibrosis (HP:0100732)	3.41319811
15	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.39902232
16	Absent/shortened dynein arms (HP:0200106)	3.39902232
17	Progressive macrocephaly (HP:0004481)	3.32969461
18	Abnormal rod and cone electroretinograms (HP:0008323)	3.32365658
19	Pancreatic cysts (HP:0001737)	3.25012228
20	Molar tooth sign on MRI (HP:0002419)	3.23923199
21	Abnormality of midbrain morphology (HP:0002418)	3.23923199
22	Increased IgM level (HP:0003496)	3.19061798
23	True hermaphroditism (HP:0010459)	3.19040011
24	Increased CSF lactate (HP:0002490)	3.11897402
25	Chronic hepatic failure (HP:0100626)	3.03799170
26	Abnormal respiratory motile cilium morphology (HP:0005938)	2.99401980
27	Abnormal respiratory epithelium morphology (HP:0012253)	2.99401980
28	Congenital stationary night blindness (HP:0007642)	2.96829846
29	Pallor (HP:0000980)	2.93141025
30	Lipid accumulation in hepatocytes (HP:0006561)	2.89579848
31	Nasal polyposis (HP:0100582)	2.82098732
32	Hepatocellular necrosis (HP:0001404)	2.80646824
33	Increased hepatocellular lipid droplets (HP:0006565)	2.73652628
34	Abnormal ciliary motility (HP:0012262)	2.71450876
35	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.70274770
36	Constricted visual fields (HP:0001133)	2.62546565
37	Optic disc pallor (HP:0000543)	2.58371718
38	Type 2 muscle fiber atrophy (HP:0003554)	2.55460893
39	Autoimmune thrombocytopenia (HP:0001973)	2.49635851
40	Cerebral edema (HP:0002181)	2.47495031
41	Abolished electroretinogram (ERG) (HP:0000550)	2.46741711
42	Elevated erythrocyte sedimentation rate (HP:0003565)	2.43404748
43	3-Methylglutaconic aciduria (HP:0003535)	2.43269310
44	Abnormal respiratory motile cilium physiology (HP:0012261)	2.40850682
45	Hepatic necrosis (HP:0002605)	2.39125157
46	Decreased central vision (HP:0007663)	2.39119975
47	Methylmalonic acidemia (HP:0002912)	2.37238466
48	Colon cancer (HP:0003003)	2.36096366
49	Hypothermia (HP:0002045)	2.34383133
50	Attenuation of retinal blood vessels (HP:0007843)	2.28296243
51	Medial flaring of the eyebrow (HP:0010747)	2.27926695
52	Renal Fanconi syndrome (HP:0001994)	2.27437686
53	Cystic liver disease (HP:0006706)	2.25623447
54	Nephronophthisis (HP:0000090)	2.25602478
55	Type II lissencephaly (HP:0007260)	2.24626044
56	Enlarged epiphyses (HP:0010580)	2.24519371
57	Abnormality of eosinophils (HP:0001879)	2.19530098
58	Sclerocornea (HP:0000647)	2.19510758
59	Bony spicule pigmentary retinopathy (HP:0007737)	2.16360485
60	Increased serum lactate (HP:0002151)	2.15339220
61	Muscle fiber atrophy (HP:0100295)	2.12265899
62	Abnormality of the nasal mucosa (HP:0000433)	2.09104754
63	Abnormal hemoglobin (HP:0011902)	2.09085231
64	Lethargy (HP:0001254)	2.03385562
65	Increased intramyocellular lipid droplets (HP:0012240)	2.03360191
66	Lactic acidosis (HP:0003128)	2.03024050
67	Polydipsia (HP:0001959)	2.02807359
68	Abnormal drinking behavior (HP:0030082)	2.02807359
69	Stenosis of the external auditory canal (HP:0000402)	2.01073050
70	IgG deficiency (HP:0004315)	2.00398962
71	Recurrent bronchitis (HP:0002837)	1.98261505
72	Anencephaly (HP:0002323)	1.97396942
73	Eosinophilia (HP:0001880)	1.96745809
74	Autoimmune hemolytic anemia (HP:0001890)	1.96738162
75	Stomatitis (HP:0010280)	1.96496713
76	Hyperalaninemia (HP:0003348)	1.95512726
77	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.95512726
78	Abnormality of alanine metabolism (HP:0010916)	1.95512726
79	Agammaglobulinemia (HP:0004432)	1.95309462
80	Absent thumb (HP:0009777)	1.94387632
81	Methylmalonic aciduria (HP:0012120)	1.94069122
82	Myotonia (HP:0002486)	1.93258426
83	Abnormality of T cell number (HP:0011839)	1.91648391
84	Increased muscle lipid content (HP:0009058)	1.91539323
85	Pendular nystagmus (HP:0012043)	1.91356861
86	Respiratory failure (HP:0002878)	1.90822075
87	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.90638480
88	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.89494402
89	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.88066424
90	Congenital, generalized hypertrichosis (HP:0004540)	1.85334393
91	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.84446220
92	Hypoproteinemia (HP:0003075)	1.83381616
93	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.83301418
94	Postaxial foot polydactyly (HP:0001830)	1.81002261
95	Hypochromic anemia (HP:0001931)	1.80884687
96	Exertional dyspnea (HP:0002875)	1.77976591
97	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.77920693
98	Increased corneal curvature (HP:0100692)	1.77536618
99	Keratoconus (HP:0000563)	1.77536618
100	Rhinitis (HP:0012384)	1.77366322

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	6.33252791
2	MAP3K13	3.54664889
3	PASK	3.03336850
4	WNK4	2.99231791
5	TXK	2.99056991
6	PIK3CA	2.88568685
7	CDK19	2.78515012
8	ADRBK2	2.52467218
9	MAP4K2	2.32412122
10	TAOK3	2.20835106
11	STK39	1.88636715
12	OXSR1	1.80473533
13	GRK1	1.78393511
14	WNK3	1.68812643
15	FRK	1.68333185
16	STK16	1.57997231
17	BMPR2	1.51033309
18	DYRK2	1.49136532
19	BCKDK	1.48137359
20	NUAK1	1.38670903
21	ZAK	1.34316813
22	PINK1	1.32412675
23	MAP4K1	1.30987084
24	TEC	1.28792855
25	CAMKK2	1.24492822
26	BMPR1B	1.23205955
27	IKBKB	1.22234615
28	CAMKK1	1.13498764
29	BTK	1.09260932
30	KIT	1.08709581
31	INSRR	1.07809368
32	NEK1	1.02775968
33	ADRBK1	0.97146955
34	MAP2K6	0.94213122
35	ITK	0.92842220
36	TIE1	0.91036981
37	SYK	0.83434719
38	LRRK2	0.81515956
39	PRKCQ	0.80565762
40	CSNK1G3	0.78173293
41	MUSK	0.77423969
42	PRKCG	0.77332244
43	TRIM28	0.75904639
44	MAPK13	0.74128577
45	MAP3K9	0.72261576
46	NEK2	0.70929505
47	DAPK2	0.70905848
48	MAP3K12	0.70384906
49	GRK7	0.69844809
50	KDR	0.67628081
51	ARAF	0.67579165
52	RPS6KA5	0.67094096
53	CSNK1G2	0.65406157
54	ILK	0.63043023
55	PLK4	0.62586131
56	LCK	0.61814431
57	OBSCN	0.60282210
58	CSNK1G1	0.60191516
59	NME2	0.59489618
60	IKBKE	0.56681539
61	TNK2	0.56451504
62	MKNK1	0.55627749
63	CSNK2A2	0.54542949
64	MAP2K2	0.53348526
65	STK11	0.52748623
66	PIK3CG	0.51651740
67	PRKACA	0.51461443
68	MOS	0.51275178
69	SIK2	0.47399181
70	CSNK1A1L	0.46718859
71	MAP2K7	0.46583653
72	LYN	0.46433836
73	CAMK1	0.45786101
74	VRK1	0.44861106
75	EPHA4	0.44797083
76	VRK2	0.44516123
77	CSNK2A1	0.44497374
78	DAPK3	0.44111551
79	MKNK2	0.43695385
80	MAP3K14	0.42713534
81	BRAF	0.42032586
82	PRKCA	0.41401528
83	MAPKAPK5	0.40144820
84	AURKA	0.40144113
85	PLK1	0.39754761
86	CSNK1A1	0.39002314
87	JAK3	0.38071226
88	TGFBR1	0.37789947
89	CAMK2A	0.36941200
90	CDK8	0.36788706
91	TNIK	0.36580026
92	GRK5	0.35544986
93	MAP3K4	0.35416324
94	RPS6KA6	0.35092842
95	IGF1R	0.34737234
96	AURKB	0.33940757
97	PHKG2	0.33834525
98	PHKG1	0.33834525
99	PRKCE	0.33080507
100	ACVR1B	0.32923659

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.83395567
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.42438837
3	Parkinsons disease_Homo sapiens_hsa05012	2.68268929
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.68062829
5	Allograft rejection_Homo sapiens_hsa05330	2.58450298
6	Caffeine metabolism_Homo sapiens_hsa00232	2.58216879
7	Asthma_Homo sapiens_hsa05310	2.54158455
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.41222019
9	Graft-versus-host disease_Homo sapiens_hsa05332	2.40765093
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.27481676
11	Type I diabetes mellitus_Homo sapiens_hsa04940	2.17131178
12	Phototransduction_Homo sapiens_hsa04744	2.03525768
13	Protein export_Homo sapiens_hsa03060	1.92663537
14	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.85957761
15	Proteasome_Homo sapiens_hsa03050	1.85130398
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.82543212
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.80499145
18	Huntingtons disease_Homo sapiens_hsa05016	1.79393300
19	RNA polymerase_Homo sapiens_hsa03020	1.77086919
20	Alzheimers disease_Homo sapiens_hsa05010	1.72987464
21	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.71316387
22	Primary immunodeficiency_Homo sapiens_hsa05340	1.68009485
23	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.63492994
24	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.58840467
25	Cardiac muscle contraction_Homo sapiens_hsa04260	1.55890832
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.51540947
27	Ether lipid metabolism_Homo sapiens_hsa00565	1.38835634
28	One carbon pool by folate_Homo sapiens_hsa00670	1.37360729
29	Homologous recombination_Homo sapiens_hsa03440	1.34337084
30	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.29367785
31	Nitrogen metabolism_Homo sapiens_hsa00910	1.24631991
32	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.24016154
33	Sulfur relay system_Homo sapiens_hsa04122	1.22292514
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.17606392
35	Olfactory transduction_Homo sapiens_hsa04740	1.15310529
36	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.13456816
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.11752776
38	Antigen processing and presentation_Homo sapiens_hsa04612	1.09886136
39	RNA degradation_Homo sapiens_hsa03018	1.09022111
40	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.04262267
41	Basal transcription factors_Homo sapiens_hsa03022	1.04177756
42	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.02712551
43	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.96665383
44	Pyrimidine metabolism_Homo sapiens_hsa00240	0.95382101
45	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.89715560
46	Rheumatoid arthritis_Homo sapiens_hsa05323	0.89608778
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.88223716
48	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.83674277
49	Fat digestion and absorption_Homo sapiens_hsa04975	0.82490233
50	Retinol metabolism_Homo sapiens_hsa00830	0.81478013
51	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.79749921
52	African trypanosomiasis_Homo sapiens_hsa05143	0.77034133
53	Folate biosynthesis_Homo sapiens_hsa00790	0.75973333
54	Fanconi anemia pathway_Homo sapiens_hsa03460	0.74520143
55	Propanoate metabolism_Homo sapiens_hsa00640	0.74295704
56	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.67591678
57	Nicotine addiction_Homo sapiens_hsa05033	0.67570892
58	Chemical carcinogenesis_Homo sapiens_hsa05204	0.66258712
59	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.66029640
60	Purine metabolism_Homo sapiens_hsa00230	0.64160776
61	Nucleotide excision repair_Homo sapiens_hsa03420	0.63271598
62	Collecting duct acid secretion_Homo sapiens_hsa04966	0.62923640
63	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.62908688
64	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.62619066
65	Base excision repair_Homo sapiens_hsa03410	0.60427382
66	Butanoate metabolism_Homo sapiens_hsa00650	0.59213297
67	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.58225724
68	Peroxisome_Homo sapiens_hsa04146	0.57417104
69	Metabolic pathways_Homo sapiens_hsa01100	0.57234341
70	Selenocompound metabolism_Homo sapiens_hsa00450	0.55361462
71	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.50833050
72	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.49566639
73	Steroid biosynthesis_Homo sapiens_hsa00100	0.48779054
74	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.48696654
75	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48163493
76	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.47057357
77	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.46755531
78	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.45075772
79	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.44945359
80	RNA transport_Homo sapiens_hsa03013	0.44658518
81	Mismatch repair_Homo sapiens_hsa03430	0.42517305
82	Viral myocarditis_Homo sapiens_hsa05416	0.42169154
83	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.40540348
84	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.40296836
85	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.38582682
86	Fatty acid degradation_Homo sapiens_hsa00071	0.36494202
87	Serotonergic synapse_Homo sapiens_hsa04726	0.34064074
88	Regulation of autophagy_Homo sapiens_hsa04140	0.33949384
89	Taste transduction_Homo sapiens_hsa04742	0.32809310
90	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.32500781
91	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.32175645
92	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.31881616
93	Morphine addiction_Homo sapiens_hsa05032	0.30766922
94	Glycerolipid metabolism_Homo sapiens_hsa00561	0.25513595
95	DNA replication_Homo sapiens_hsa03030	0.24163012
96	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.23627153
97	Insulin secretion_Homo sapiens_hsa04911	0.21859958
98	Spliceosome_Homo sapiens_hsa03040	0.21486326
99	Malaria_Homo sapiens_hsa05144	0.20308897
100	Tyrosine metabolism_Homo sapiens_hsa00350	0.19306605

RPL5P34

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »