RPL5P35

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)5.30247631
2translational termination (GO:0006415)5.18429319
3ribosomal small subunit assembly (GO:0000028)5.06757379
4ribosomal large subunit biogenesis (GO:0042273)5.03342853
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.79680301
6cotranslational protein targeting to membrane (GO:0006613)4.68737974
7protein targeting to ER (GO:0045047)4.64053831
8tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.62086301
9RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.62086301
10mitochondrial respiratory chain complex I assembly (GO:0032981)4.58811097
11NADH dehydrogenase complex assembly (GO:0010257)4.58811097
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.58811097
13water-soluble vitamin biosynthetic process (GO:0042364)4.52530170
14protein complex biogenesis (GO:0070271)4.52464680
15establishment of protein localization to mitochondrial membrane (GO:0090151)4.49291964
16translational elongation (GO:0006414)4.47384212
17establishment of protein localization to endoplasmic reticulum (GO:0072599)4.43763448
18protein localization to endoplasmic reticulum (GO:0070972)4.40549352
19ATP synthesis coupled proton transport (GO:0015986)4.40342666
20energy coupled proton transport, down electrochemical gradient (GO:0015985)4.40342666
21respiratory chain complex IV assembly (GO:0008535)4.38327290
22termination of RNA polymerase III transcription (GO:0006386)4.30485492
23transcription elongation from RNA polymerase III promoter (GO:0006385)4.30485492
24chaperone-mediated protein transport (GO:0072321)4.21203539
25mitochondrial respiratory chain complex assembly (GO:0033108)4.16828084
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.16039972
27mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.07863927
28ribosomal small subunit biogenesis (GO:0042274)3.98691135
29viral life cycle (GO:0019058)3.88791865
30DNA deamination (GO:0045006)3.80479814
31translational initiation (GO:0006413)3.79487644
32protein neddylation (GO:0045116)3.73092317
33cellular protein complex disassembly (GO:0043624)3.72842115
34maturation of SSU-rRNA (GO:0030490)3.72099502
35cytochrome complex assembly (GO:0017004)3.69793617
36nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.69671155
37translation (GO:0006412)3.68415317
38behavioral response to nicotine (GO:0035095)3.62882040
39cellular component biogenesis (GO:0044085)3.57922056
40aldehyde catabolic process (GO:0046185)3.54441744
41nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.50050324
42respiratory electron transport chain (GO:0022904)3.46315222
43electron transport chain (GO:0022900)3.45096448
44exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.42438058
45ribonucleoprotein complex biogenesis (GO:0022613)3.38962686
46regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.18319363
47regulation of cellular respiration (GO:0043457)3.16750172
48platelet dense granule organization (GO:0060155)3.13863940
49positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.13717644
50pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.09005107
51GTP biosynthetic process (GO:0006183)3.08123584
52rRNA modification (GO:0000154)3.07663052
53ubiquinone biosynthetic process (GO:0006744)3.06519177
54protein targeting to membrane (GO:0006612)3.03412189
55protein complex disassembly (GO:0043241)3.02803631
56nuclear-transcribed mRNA catabolic process (GO:0000956)2.93929657
57epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.89581914
58intracellular protein transmembrane import (GO:0044743)2.89518777
59piRNA metabolic process (GO:0034587)2.89393178
60protein localization to cilium (GO:0061512)2.89354182
61purine nucleoside triphosphate biosynthetic process (GO:0009145)2.88589134
62macromolecular complex disassembly (GO:0032984)2.87745723
63protein-cofactor linkage (GO:0018065)2.87467194
64purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.86544943
65tRNA processing (GO:0008033)2.86041741
66positive regulation of interleukin-17 production (GO:0032740)2.83021988
67iron-sulfur cluster assembly (GO:0016226)2.81336204
68metallo-sulfur cluster assembly (GO:0031163)2.81336204
69ATP biosynthetic process (GO:0006754)2.79730636
70rRNA processing (GO:0006364)2.79090567
71protein prenylation (GO:0018342)2.77125542
72prenylation (GO:0097354)2.77125542
73mRNA catabolic process (GO:0006402)2.75543998
74response to pheromone (GO:0019236)2.73937860
75rRNA metabolic process (GO:0016072)2.72536171
76preassembly of GPI anchor in ER membrane (GO:0016254)2.69628644
77ubiquinone metabolic process (GO:0006743)2.69020741
78detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.67898593
79regulation of cilium movement (GO:0003352)2.66212719
80peptidyl-histidine modification (GO:0018202)2.65276623
81pyrimidine nucleotide catabolic process (GO:0006244)2.64893901
82positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.63388231
83pseudouridine synthesis (GO:0001522)2.63222502
84protein targeting to mitochondrion (GO:0006626)2.61789191
85base-excision repair, AP site formation (GO:0006285)2.61582408
86regulation of chronic inflammatory response (GO:0002676)2.60030197
87ribosome biogenesis (GO:0042254)2.59674784
88proteasome assembly (GO:0043248)2.58949546
89negative regulation of T cell differentiation in thymus (GO:0033085)2.58433874
90regulation of isotype switching to IgG isotypes (GO:0048302)2.56453517
91establishment of protein localization to mitochondrion (GO:0072655)2.56015988
92RNA catabolic process (GO:0006401)2.55679722
93L-fucose catabolic process (GO:0042355)2.54196053
94fucose catabolic process (GO:0019317)2.54196053
95L-fucose metabolic process (GO:0042354)2.54196053
96UTP biosynthetic process (GO:0006228)2.53477146
97regulation of immunoglobulin secretion (GO:0051023)2.52390198
98hydrogen ion transmembrane transport (GO:1902600)2.49433240
99tRNA metabolic process (GO:0006399)2.47506522
100RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.45762619

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.14835496
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.05619458
3EZH2_22144423_ChIP-Seq_EOC_Human3.40183459
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.13479266
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.11822822
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.01302534
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.89135324
8ZNF274_21170338_ChIP-Seq_K562_Hela2.84256455
9VDR_22108803_ChIP-Seq_LS180_Human2.74658502
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.53876625
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.47938464
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.44178480
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.36655382
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.30985767
15VDR_23849224_ChIP-Seq_CD4+_Human2.22770036
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.09585535
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.02097853
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98325415
19ELK1_19687146_ChIP-ChIP_HELA_Human1.97693207
20FOXP3_21729870_ChIP-Seq_TREG_Human1.90794223
21SALL1_21062744_ChIP-ChIP_HESCs_Human1.84420322
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83721651
23TP53_22573176_ChIP-Seq_HFKS_Human1.81866355
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.81366965
25TAF15_26573619_Chip-Seq_HEK293_Human1.80830216
26EWS_26573619_Chip-Seq_HEK293_Human1.77495755
27PCGF2_27294783_Chip-Seq_NPCs_Mouse1.73387667
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68620340
29GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.60824014
30MYC_18940864_ChIP-ChIP_HL60_Human1.59692532
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59234556
32P300_19829295_ChIP-Seq_ESCs_Human1.55227167
33TTF2_22483619_ChIP-Seq_HELA_Human1.50257168
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.48175053
35FUS_26573619_Chip-Seq_HEK293_Human1.47045985
36IGF1R_20145208_ChIP-Seq_DFB_Human1.44295209
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43238699
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42253983
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41080291
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40835520
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36529698
42CBP_20019798_ChIP-Seq_JUKART_Human1.33946900
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33946900
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33665175
45FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32553858
46FOXA1_25329375_ChIP-Seq_VCAP_Human1.32553858
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28908759
48ER_23166858_ChIP-Seq_MCF-7_Human1.28476315
49NANOG_19829295_ChIP-Seq_ESCs_Human1.24224675
50SOX2_19829295_ChIP-Seq_ESCs_Human1.24224675
51CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.21603557
52NCOR_22424771_ChIP-Seq_293T_Human1.19637050
53NANOG_20526341_ChIP-Seq_ESCs_Human1.19398804
54KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18967981
55AR_20517297_ChIP-Seq_VCAP_Human1.18516858
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18131909
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17955341
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.14514553
59GABP_19822575_ChIP-Seq_HepG2_Human1.14267119
60FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13179445
61AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12605861
62HTT_18923047_ChIP-ChIP_STHdh_Human1.11680379
63PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.11670789
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10624468
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10036923
66FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09668165
67BP1_19119308_ChIP-ChIP_Hs578T_Human1.09553529
68BCAT_22108803_ChIP-Seq_LS180_Human1.09361411
69DCP1A_22483619_ChIP-Seq_HELA_Human1.09253518
70ERG_20517297_ChIP-Seq_VCAP_Human1.07230790
71ELK1_22589737_ChIP-Seq_MCF10A_Human1.07000556
72EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.06047913
73FOXH1_21741376_ChIP-Seq_EPCs_Human1.04780988
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03726377
75GATA3_26560356_Chip-Seq_TH2_Human1.03232392
76TAF2_19829295_ChIP-Seq_ESCs_Human1.01239988
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01214388
78PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00895214
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00662782
80FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99856806
81EZH2_27294783_Chip-Seq_NPCs_Mouse0.99078859
82GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98785889
83HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98338885
84HOXB7_26014856_ChIP-Seq_BT474_Human0.98176996
85GATA3_21878914_ChIP-Seq_MCF-7_Human0.97251227
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96780851
87LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95992536
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95811573
89NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.95739452
90MYC_19079543_ChIP-ChIP_MESCs_Mouse0.95507712
91TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94313097
92NOTCH1_21737748_ChIP-Seq_TLL_Human0.94056957
93ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93158526
94TCF4_22108803_ChIP-Seq_LS180_Human0.92384628
95GBX2_23144817_ChIP-Seq_PC3_Human0.92138653
96RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.91965702
97PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91892543
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91338516
99POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89561687
100FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88677676

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.00734062
2MP0008877_abnormal_DNA_methylation3.45300386
3MP0002837_dystrophic_cardiac_calcinosis3.22845432
4MP0002102_abnormal_ear_morphology2.83861713
5MP0003787_abnormal_imprinting2.81170316
6MP0002163_abnormal_gland_morphology2.61503722
7MP0001835_abnormal_antigen_presentation2.41414806
8MP0002653_abnormal_ependyma_morphology2.31548596
9MP0009379_abnormal_foot_pigmentation2.30328183
10MP0004147_increased_porphyrin_level2.29746110
11MP0005379_endocrine/exocrine_gland_phen2.27182948
12MP0004145_abnormal_muscle_electrophysio2.25123528
13MP0002876_abnormal_thyroid_physiology2.15840000
14MP0008872_abnormal_physiological_respon2.09838147
15MP0003878_abnormal_ear_physiology2.08465293
16MP0005377_hearing/vestibular/ear_phenot2.08465293
17MP0005671_abnormal_response_to2.01492410
18MP0004142_abnormal_muscle_tone1.97654075
19MP0000372_irregular_coat_pigmentation1.96561950
20MP0005646_abnormal_pituitary_gland1.93387583
21MP0003186_abnormal_redox_activity1.92584424
22MP0005084_abnormal_gallbladder_morpholo1.89636325
23MP0004084_abnormal_cardiac_muscle1.82558178
24MP0008789_abnormal_olfactory_epithelium1.80426308
25MP0005645_abnormal_hypothalamus_physiol1.77236617
26MP0002138_abnormal_hepatobiliary_system1.70235278
27MP0005551_abnormal_eye_electrophysiolog1.59768114
28MP0002160_abnormal_reproductive_system1.58887759
29MP0001348_abnormal_lacrimal_gland1.56274139
30MP0008875_abnormal_xenobiotic_pharmacok1.54296090
31MP0005389_reproductive_system_phenotype1.42929691
32MP0001529_abnormal_vocalization1.40728589
33MP0006036_abnormal_mitochondrial_physio1.36228246
34MP0003011_delayed_dark_adaptation1.35682140
35MP0001968_abnormal_touch/_nociception1.34551151
36MP0009785_altered_susceptibility_to1.34517606
37MP0003567_abnormal_fetal_cardiomyocyte1.34007472
38MP0006072_abnormal_retinal_apoptosis1.32620870
39MP0001764_abnormal_homeostasis1.27143284
40MP0005394_taste/olfaction_phenotype1.15753036
41MP0005499_abnormal_olfactory_system1.15753036
42MP0002148_abnormal_hypersensitivity_rea1.15123499
43MP0001800_abnormal_humoral_immune1.14301166
44MP0009333_abnormal_splenocyte_physiolog1.14210429
45MP0005410_abnormal_fertilization1.14065752
46MP0006276_abnormal_autonomic_nervous1.13132535
47MP0001905_abnormal_dopamine_level1.09872396
48MP0000685_abnormal_immune_system1.09471443
49MP0001984_abnormal_olfaction1.06625340
50MP0001293_anophthalmia1.06296178
51MP0003718_maternal_effect1.05959187
52MP0003646_muscle_fatigue1.05478978
53MP0003195_calcinosis1.02773286
54MP0004885_abnormal_endolymph1.02366346
55MP0001919_abnormal_reproductive_system0.99310682
56MP0001502_abnormal_circadian_rhythm0.99264311
57MP0002736_abnormal_nociception_after0.99172239
58MP0001986_abnormal_taste_sensitivity0.99005693
59MP0006054_spinal_hemorrhage0.98476288
60MP0002095_abnormal_skin_pigmentation0.97157319
61MP0005253_abnormal_eye_physiology0.97033471
62MP0006035_abnormal_mitochondrial_morpho0.96924680
63MP0003880_abnormal_central_pattern0.96740616
64MP0003252_abnormal_bile_duct0.95700480
65MP0002132_abnormal_respiratory_system0.94103494
66MP0005332_abnormal_amino_acid0.93579919
67MP0008775_abnormal_heart_ventricle0.93561840
68MP0009764_decreased_sensitivity_to0.92117279
69MP0002277_abnormal_respiratory_mucosa0.91322521
70MP0009745_abnormal_behavioral_response0.91233279
71MP0002733_abnormal_thermal_nociception0.90814862
72MP0002272_abnormal_nervous_system0.90599293
73MP0003121_genomic_imprinting0.89467419
74MP0001970_abnormal_pain_threshold0.88459313
75MP0002693_abnormal_pancreas_physiology0.87319846
76MP0005075_abnormal_melanosome_morpholog0.85310461
77MP0003806_abnormal_nucleotide_metabolis0.83088532
78MP0000631_abnormal_neuroendocrine_gland0.82906463
79MP0005636_abnormal_mineral_homeostasis0.81693813
80MP0002822_catalepsy0.79682171
81MP0002210_abnormal_sex_determination0.78042675
82MP0000230_abnormal_systemic_arterial0.77059413
83MP0002735_abnormal_chemical_nociception0.76641650
84MP0008058_abnormal_DNA_repair0.76627184
85MP0004036_abnormal_muscle_relaxation0.76407672
86MP0000049_abnormal_middle_ear0.75373547
87MP0004215_abnormal_myocardial_fiber0.74123904
88MP0001485_abnormal_pinna_reflex0.72991689
89MP0002006_tumorigenesis0.72627971
90MP0003786_premature_aging0.70854331
91MP0010155_abnormal_intestine_physiology0.69478524
92MP0001486_abnormal_startle_reflex0.67062663
93MP0001929_abnormal_gametogenesis0.66279946
94MP0009046_muscle_twitch0.64744611
95MP0002723_abnormal_immune_serum0.64619649
96MP0001145_abnormal_male_reproductive0.64113173
97MP0002751_abnormal_autonomic_nervous0.62670153
98MP0005195_abnormal_posterior_eye0.62602155
99MP0001963_abnormal_hearing_physiology0.62244891
100MP0001119_abnormal_female_reproductive0.62168546

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.83232394
2Mitochondrial inheritance (HP:0001427)4.51229811
3Abnormal mitochondria in muscle tissue (HP:0008316)4.32580687
4Hepatocellular necrosis (HP:0001404)4.10760602
5Progressive macrocephaly (HP:0004481)4.04195028
6Increased CSF lactate (HP:0002490)4.02706254
7Acute encephalopathy (HP:0006846)3.98281231
8Abnormality of midbrain morphology (HP:0002418)3.84349423
9Molar tooth sign on MRI (HP:0002419)3.84349423
10Hypoproteinemia (HP:0003075)3.81356320
113-Methylglutaconic aciduria (HP:0003535)3.53710405
12Absent rod-and cone-mediated responses on ERG (HP:0007688)3.53273835
13B lymphocytopenia (HP:0010976)3.51202585
14Hepatic necrosis (HP:0002605)3.48999977
15Pancreatic cysts (HP:0001737)3.36440896
16Abnormality of B cell number (HP:0010975)3.28441486
17Increased hepatocellular lipid droplets (HP:0006565)3.24367493
18Pancreatic fibrosis (HP:0100732)3.22289371
19Nephronophthisis (HP:0000090)3.21368323
20Lipid accumulation in hepatocytes (HP:0006561)3.19969630
21True hermaphroditism (HP:0010459)3.16482845
22Abnormal rod and cone electroretinograms (HP:0008323)3.11080400
23Cerebral edema (HP:0002181)3.10287490
24Optic disc pallor (HP:0000543)3.02089932
25Chronic hepatic failure (HP:0100626)2.91292623
26Absent/shortened dynein arms (HP:0200106)2.90968307
27Dynein arm defect of respiratory motile cilia (HP:0012255)2.90968307
28Increased serum lactate (HP:0002151)2.88064456
29IgG deficiency (HP:0004315)2.73331477
30Abnormality of cells of the erythroid lineage (HP:0012130)2.69602725
31Renal Fanconi syndrome (HP:0001994)2.67472535
32Severe combined immunodeficiency (HP:0004430)2.57104860
33Abnormal number of erythroid precursors (HP:0012131)2.53694831
34Abnormality of the renal medulla (HP:0100957)2.51991825
35Increased intramyocellular lipid droplets (HP:0012240)2.51749471
36Methylmalonic acidemia (HP:0002912)2.51343780
37Panhypogammaglobulinemia (HP:0003139)2.45384610
38Macrocytic anemia (HP:0001972)2.44988799
39Thyroiditis (HP:0100646)2.44585336
40Attenuation of retinal blood vessels (HP:0007843)2.42430205
41Lactic acidosis (HP:0003128)2.35962908
42Leukodystrophy (HP:0002415)2.35462633
43Abnormal respiratory motile cilium morphology (HP:0005938)2.35261834
44Abnormal respiratory epithelium morphology (HP:0012253)2.35261834
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.32126203
46Decreased activity of mitochondrial respiratory chain (HP:0008972)2.30408722
47Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.30408722
48Type 2 muscle fiber atrophy (HP:0003554)2.27592200
49Abnormal ciliary motility (HP:0012262)2.27341477
50Type II lissencephaly (HP:0007260)2.27309116
51Respiratory failure (HP:0002878)2.27163634
52Decreased central vision (HP:0007663)2.25601781
53Reticulocytopenia (HP:0001896)2.24018118
54Abolished electroretinogram (ERG) (HP:0000550)2.23942781
55Cystic liver disease (HP:0006706)2.23897644
56Abnormality of the pons (HP:0007361)2.19001342
57Increased muscle lipid content (HP:0009058)2.18076761
58Stenosis of the external auditory canal (HP:0000402)2.16260670
59Stomatitis (HP:0010280)2.14442472
60Constricted visual fields (HP:0001133)2.13931504
61Pendular nystagmus (HP:0012043)2.12011639
62Postaxial foot polydactyly (HP:0001830)2.10108950
63Elevated erythrocyte sedimentation rate (HP:0003565)2.07626539
64Exercise intolerance (HP:0003546)2.07609561
65Erythroderma (HP:0001019)2.07434651
66Hypoplasia of the pons (HP:0012110)2.07377572
67Sclerocornea (HP:0000647)2.07248818
68Congenital stationary night blindness (HP:0007642)2.07150394
69Lethargy (HP:0001254)2.04194693
70Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.02521589
71Abnormality of urine glucose concentration (HP:0011016)2.01502570
72Glycosuria (HP:0003076)2.01502570
73Exertional dyspnea (HP:0002875)2.00457402
74Medial flaring of the eyebrow (HP:0010747)1.96667195
75Methylmalonic aciduria (HP:0012120)1.95231449
76CNS demyelination (HP:0007305)1.92732516
77Decreased electroretinogram (ERG) amplitude (HP:0000654)1.92701840
78Male pseudohermaphroditism (HP:0000037)1.92166591
79Abnormality of renal resorption (HP:0011038)1.91392458
80Abnormal respiratory motile cilium physiology (HP:0012261)1.90533877
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88549782
82Abnormality of alanine metabolism (HP:0010916)1.88549782
83Hyperalaninemia (HP:0003348)1.88549782
84Muscle fiber atrophy (HP:0100295)1.86841736
85Chronic sinusitis (HP:0011109)1.85732883
86Cerebellar dysplasia (HP:0007033)1.85341437
87Aplasia/Hypoplasia of the tongue (HP:0010295)1.84514472
88Hypoplasia of the thymus (HP:0000778)1.80923783
89Combined immunodeficiency (HP:0005387)1.76843805
90Eosinophilia (HP:0001880)1.76424830
91Cleft eyelid (HP:0000625)1.76171616
92Bony spicule pigmentary retinopathy (HP:0007737)1.75909497
93Pallor (HP:0000980)1.75722189
94Polydipsia (HP:0001959)1.72210648
95Abnormal drinking behavior (HP:0030082)1.72210648
96Aplasia/hypoplasia of the uterus (HP:0008684)1.72192675
97Testicular atrophy (HP:0000029)1.70097971
98Microvesicular hepatic steatosis (HP:0001414)1.67658892
99X-linked dominant inheritance (HP:0001423)1.64536379
100Aplasia/Hypoplasia of the spleen (HP:0010451)1.63897826

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK4.15390049
2TXK3.92784505
3ZAK3.07049091
4ADRBK22.82736548
5MAP3K122.49628397
6CDK192.48342482
7WNK42.30436856
8GRK12.28164594
9BCKDK2.19231740
10STK162.09637659
11TLK11.94274639
12INSRR1.84165491
13PBK1.84012168
14NEK11.80606707
15MAP4K11.75571581
16FRK1.73474872
17NUAK11.68845330
18BUB11.67679280
19DYRK21.67273560
20PIK3CG1.51851068
21SCYL21.50054603
22PINK11.46600317
23CAMKK11.45900443
24BMPR1B1.42069579
25WNK31.40993295
26TAOK31.40240822
27TIE11.37180585
28MST41.33915833
29MAP3K131.32155410
30STK391.23694796
31EIF2AK31.19446089
32CAMKK21.16726357
33MUSK1.10562279
34MAP4K21.09054078
35TRIM281.08628701
36NME21.08509533
37TEC1.06631356
38MAP2K60.97353035
39OXSR10.97270460
40ITK0.96726975
41VRK10.94853060
42IKBKB0.90879139
43PRKCQ0.90668852
44STK38L0.88035077
45TGFBR10.87796059
46NME10.86006146
47BMPR20.85973400
48TSSK60.84814562
49PLK40.82442273
50BRSK20.76215601
51BTK0.73256716
52MAP3K40.72818173
53ADRBK10.72622236
54EIF2AK10.71705736
55SYK0.70315475
56VRK20.69666769
57PLK30.69527618
58MAP3K140.68705079
59FES0.68411080
60CASK0.67112736
61DAPK20.67043904
62KIT0.65657894
63RPS6KA50.64005911
64LYN0.60845893
65NEK20.59969268
66PRKCE0.59549890
67CSNK1G30.58885991
68PRKCG0.58528072
69MATK0.57755092
70CSNK1G20.54744012
71CSNK1G10.51574514
72LCK0.50454983
73MYLK0.48836739
74MKNK10.48191363
75ATR0.48150108
76MAPK130.47850790
77TAF10.47782473
78CSNK2A20.47692904
79PLK10.46458956
80TNK20.45238039
81OBSCN0.43851507
82LRRK20.43818370
83CSNK2A10.43630731
84SIK20.42686061
85PIM20.40426571
86PRKD30.40108390
87MKNK20.39852987
88CSNK1E0.38400003
89DAPK10.38338616
90PRKACA0.38282277
91PRKCA0.36548842
92PRKG10.36501932
93JAK30.32608196
94PRKCD0.31406726
95PRKCH0.30725567
96CSNK1A1L0.30439075
97ABL20.30184104
98PHKG10.29562794
99PHKG20.29562794
100CSF1R0.29124982

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.69207452
2Oxidative phosphorylation_Homo sapiens_hsa001903.52801516
3Proteasome_Homo sapiens_hsa030503.17678230
4Asthma_Homo sapiens_hsa053103.02113122
5Protein export_Homo sapiens_hsa030603.01841910
6Parkinsons disease_Homo sapiens_hsa050122.97905235
7RNA polymerase_Homo sapiens_hsa030202.95135633
8Allograft rejection_Homo sapiens_hsa053302.56042294
9Autoimmune thyroid disease_Homo sapiens_hsa053202.40546611
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.13373068
11Type I diabetes mellitus_Homo sapiens_hsa049402.06482976
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.96674183
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.96032181
14Homologous recombination_Homo sapiens_hsa034401.93189254
15Graft-versus-host disease_Homo sapiens_hsa053321.87872206
16Alzheimers disease_Homo sapiens_hsa050101.86513386
17Huntingtons disease_Homo sapiens_hsa050161.84630026
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.77098716
19Phototransduction_Homo sapiens_hsa047441.76563730
20One carbon pool by folate_Homo sapiens_hsa006701.65214325
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54281081
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52867062
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.50454367
24RNA degradation_Homo sapiens_hsa030181.46438133
25Linoleic acid metabolism_Homo sapiens_hsa005911.45426621
26Pyrimidine metabolism_Homo sapiens_hsa002401.39001208
27Primary immunodeficiency_Homo sapiens_hsa053401.38313467
28Cardiac muscle contraction_Homo sapiens_hsa042601.38184166
29Propanoate metabolism_Homo sapiens_hsa006401.36725822
30Basal transcription factors_Homo sapiens_hsa030221.34684169
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33142823
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26279736
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19679200
34Rheumatoid arthritis_Homo sapiens_hsa053231.19021446
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12289052
36Caffeine metabolism_Homo sapiens_hsa002321.11946852
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10323948
38Nitrogen metabolism_Homo sapiens_hsa009101.08109215
39Purine metabolism_Homo sapiens_hsa002301.04583691
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.02456101
41Mismatch repair_Homo sapiens_hsa034301.00036157
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99089187
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97519126
44RNA transport_Homo sapiens_hsa030130.95473411
45Base excision repair_Homo sapiens_hsa034100.94092549
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93909533
47Regulation of autophagy_Homo sapiens_hsa041400.92747858
48Fanconi anemia pathway_Homo sapiens_hsa034600.91897667
49Nucleotide excision repair_Homo sapiens_hsa034200.91571981
50Tryptophan metabolism_Homo sapiens_hsa003800.90275824
51Butanoate metabolism_Homo sapiens_hsa006500.85326631
52Olfactory transduction_Homo sapiens_hsa047400.83513491
53DNA replication_Homo sapiens_hsa030300.83063310
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79761007
55Peroxisome_Homo sapiens_hsa041460.76945787
56Metabolic pathways_Homo sapiens_hsa011000.69418130
57Arachidonic acid metabolism_Homo sapiens_hsa005900.67195857
58Retinol metabolism_Homo sapiens_hsa008300.64942579
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64356800
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64221978
61Hematopoietic cell lineage_Homo sapiens_hsa046400.60427047
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.59034622
63Spliceosome_Homo sapiens_hsa030400.58794946
64Non-homologous end-joining_Homo sapiens_hsa034500.57765147
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55399342
66Antigen processing and presentation_Homo sapiens_hsa046120.54519346
67Collecting duct acid secretion_Homo sapiens_hsa049660.54395457
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54375807
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54138784
70Sulfur metabolism_Homo sapiens_hsa009200.54112383
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51637395
72Ether lipid metabolism_Homo sapiens_hsa005650.51522251
73Selenocompound metabolism_Homo sapiens_hsa004500.49748744
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48532462
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47812993
76Fat digestion and absorption_Homo sapiens_hsa049750.47327457
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.47115171
78Chemical carcinogenesis_Homo sapiens_hsa052040.46737407
79Folate biosynthesis_Homo sapiens_hsa007900.46508660
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45895356
81Sulfur relay system_Homo sapiens_hsa041220.43520394
82Nicotine addiction_Homo sapiens_hsa050330.43111445
83Fatty acid elongation_Homo sapiens_hsa000620.42553726
84Glutathione metabolism_Homo sapiens_hsa004800.41930169
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41004988
86Viral myocarditis_Homo sapiens_hsa054160.40763319
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39517686
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.37648036
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36664471
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.33335761
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33037249
92Systemic lupus erythematosus_Homo sapiens_hsa053220.32460167
93Taste transduction_Homo sapiens_hsa047420.32310576
94Steroid biosynthesis_Homo sapiens_hsa001000.30716398
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28546554
96Fatty acid degradation_Homo sapiens_hsa000710.28333061
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27715933
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.26521893
99Pyruvate metabolism_Homo sapiens_hsa006200.23310325
100p53 signaling pathway_Homo sapiens_hsa041150.20973147

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