ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.33874151
2	viral transcription (GO:0019083)	5.30038307
3	translational termination (GO:0006415)	5.15331873
4	maturation of SSU-rRNA (GO:0030490)	4.85280015
5	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.82799225
6	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.58142365
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.46451381
8	cotranslational protein targeting to membrane (GO:0006613)	4.39272889
9	protein targeting to ER (GO:0045047)	4.35778084
10	DNA deamination (GO:0045006)	4.35357088
11	translational elongation (GO:0006414)	4.33367204
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.21573054
13	neuron fate determination (GO:0048664)	4.21330016
14	behavioral response to nicotine (GO:0035095)	4.19789557
15	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.18282326
16	ribosomal small subunit biogenesis (GO:0042274)	4.15029037
17	protein localization to endoplasmic reticulum (GO:0070972)	4.11871783
18	viral life cycle (GO:0019058)	3.88503668
19	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.86404119
20	ATP synthesis coupled proton transport (GO:0015986)	3.86404119
21	cellular protein complex disassembly (GO:0043624)	3.81772479
22	central nervous system myelination (GO:0022010)	3.78501568
23	axon ensheathment in central nervous system (GO:0032291)	3.78501568
24	water-soluble vitamin biosynthetic process (GO:0042364)	3.73886193
25	epithelial cilium movement (GO:0003351)	3.70389617
26	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.61702962
27	ubiquinone biosynthetic process (GO:0006744)	3.59379693
28	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.53587879
29	protein neddylation (GO:0045116)	3.51839070
30	negative regulation of astrocyte differentiation (GO:0048712)	3.49783202
31	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.48166655
32	NADH dehydrogenase complex assembly (GO:0010257)	3.48166655
33	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.48166655
34	electron transport chain (GO:0022900)	3.43717329
35	base-excision repair, AP site formation (GO:0006285)	3.43677616
36	protein complex biogenesis (GO:0070271)	3.43461472
37	respiratory electron transport chain (GO:0022904)	3.42361437
38	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	3.40856818
39	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.39566664
40	ribosomal large subunit biogenesis (GO:0042273)	3.29711894
41	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.29276570
42	kynurenine metabolic process (GO:0070189)	3.28612821
43	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.25339606
44	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.25339606
45	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.25218820
46	translational initiation (GO:0006413)	3.24907040
47	cell proliferation in forebrain (GO:0021846)	3.24400413
48	ubiquinone metabolic process (GO:0006743)	3.23168807
49	protein complex disassembly (GO:0043241)	3.08047641
50	mitochondrial respiratory chain complex assembly (GO:0033108)	3.05955245
51	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.04734259
52	regulation of cilium movement (GO:0003352)	3.02685379
53	translation (GO:0006412)	2.98457667
54	tryptophan catabolic process (GO:0006569)	2.98274046
55	indole-containing compound catabolic process (GO:0042436)	2.98274046
56	indolalkylamine catabolic process (GO:0046218)	2.98274046
57	quinone biosynthetic process (GO:1901663)	2.97722687
58	substrate-independent telencephalic tangential migration (GO:0021826)	2.96649218
59	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.96649218
60	sulfation (GO:0051923)	2.95370016
61	indolalkylamine metabolic process (GO:0006586)	2.95008877
62	chaperone-mediated protein transport (GO:0072321)	2.94778204
63	macromolecular complex disassembly (GO:0032984)	2.93369289
64	auditory receptor cell differentiation (GO:0042491)	2.92059547
65	cilium movement (GO:0003341)	2.90800719
66	respiratory chain complex IV assembly (GO:0008535)	2.88747418
67	pyrimidine nucleotide catabolic process (GO:0006244)	2.87061727
68	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.83092242
69	protein targeting to membrane (GO:0006612)	2.82939218
70	synaptic transmission, cholinergic (GO:0007271)	2.76133086
71	positive regulation of protein homodimerization activity (GO:0090073)	2.71385851
72	nonmotile primary cilium assembly (GO:0035058)	2.70998745
73	otic vesicle formation (GO:0030916)	2.69538055
74	somite development (GO:0061053)	2.68590980
75	axoneme assembly (GO:0035082)	2.67619061
76	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.66651770
77	mRNA catabolic process (GO:0006402)	2.64775725
78	regulation of action potential (GO:0098900)	2.64330695
79	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.61849066
80	platelet dense granule organization (GO:0060155)	2.61196995
81	axonemal dynein complex assembly (GO:0070286)	2.58482399
82	cytochrome complex assembly (GO:0017004)	2.58317860
83	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.57524288
84	intraciliary transport (GO:0042073)	2.56689279
85	cellular component biogenesis (GO:0044085)	2.56554880
86	cytidine deamination (GO:0009972)	2.55932320
87	cytidine metabolic process (GO:0046087)	2.55932320
88	cytidine catabolic process (GO:0006216)	2.55932320
89	mannosylation (GO:0097502)	2.55076386
90	tryptophan metabolic process (GO:0006568)	2.54986172
91	ATP biosynthetic process (GO:0006754)	2.54678650
92	segment specification (GO:0007379)	2.51233388
93	left/right axis specification (GO:0070986)	2.50966113
94	behavioral response to ethanol (GO:0048149)	2.47642807
95	piRNA metabolic process (GO:0034587)	2.47124516
96	regulation of hypersensitivity (GO:0002883)	2.46241967
97	hydrogen ion transmembrane transport (GO:1902600)	2.45924965
98	intracellular protein transmembrane import (GO:0044743)	2.45367302
99	positive regulation of T cell apoptotic process (GO:0070234)	2.44420016
100	RNA catabolic process (GO:0006401)	2.43195404

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.22787628
2	VDR_22108803_ChIP-Seq_LS180_Human	3.09822682
3	ZNF274_21170338_ChIP-Seq_K562_Hela	2.93401371
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.86801262
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.76964884
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.68190131
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.54090175
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.54083480
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.48612128
10	FUS_26573619_Chip-Seq_HEK293_Human	2.37040752
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.24989403
12	EWS_26573619_Chip-Seq_HEK293_Human	2.23261794
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.22076232
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.18026592
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.04219965
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.02050414
17	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.01022119
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.99705027
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.93838365
20	P300_19829295_ChIP-Seq_ESCs_Human	1.89123350
21	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.87871923
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.83171190
23	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.76652852
24	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.73121466
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.70030868
26	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.69555010
27	ELK1_19687146_ChIP-ChIP_HELA_Human	1.65592116
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.60923145
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.60923145
30	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.56601997
31	MYC_18940864_ChIP-ChIP_HL60_Human	1.55022952
32	VDR_23849224_ChIP-Seq_CD4+_Human	1.52923471
33	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.52277506
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.51425942
35	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.48507091
36	RNF2_27304074_Chip-Seq_NSC_Mouse	1.45768439
37	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.45622202
38	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.39593031
39	TAF15_26573619_Chip-Seq_HEK293_Human	1.36531553
40	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.34757680
41	ER_23166858_ChIP-Seq_MCF-7_Human	1.34393750
42	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.33314021
43	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.32418954
44	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.31129258
45	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.30747417
46	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.29938682
47	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28352167
48	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.28352167
49	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.28285129
50	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.27619532
51	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.24144635
52	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.23559104
53	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.23053800
54	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.22930422
55	TCF4_22108803_ChIP-Seq_LS180_Human	1.22907025
56	IRF1_19129219_ChIP-ChIP_H3396_Human	1.22471719
57	NANOG_19829295_ChIP-Seq_ESCs_Human	1.22209606
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.22209606
59	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.20407577
60	BCAT_22108803_ChIP-Seq_LS180_Human	1.20357756
61	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.19193782
62	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.17398910
63	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.16751362
64	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.16183116
65	REST_21632747_ChIP-Seq_MESCs_Mouse	1.15982915
66	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.15938857
67	NCOR_22424771_ChIP-Seq_293T_Human	1.12560399
68	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.12385893
69	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.11337637
70	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.11069276
71	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.10835790
72	SMAD4_21799915_ChIP-Seq_A2780_Human	1.10601486
73	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08985315
74	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.08709343
75	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.06668479
76	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.06668479
77	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.06589339
78	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.06023568
79	AR_20517297_ChIP-Seq_VCAP_Human	1.05988303
80	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.05124556
81	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.05058653
82	TAF2_19829295_ChIP-Seq_ESCs_Human	1.02864611
83	STAT3_23295773_ChIP-Seq_U87_Human	1.02574574
84	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.00778935
85	RUNX2_22187159_ChIP-Seq_PCA_Human	1.00409032
86	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.99475286
87	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.99442849
88	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.99272400
89	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.99028674
90	TCF4_23295773_ChIP-Seq_U87_Human	0.98166981
91	AR_25329375_ChIP-Seq_VCAP_Human	0.98008307
92	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.97845330
93	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97679438
94	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.97164566
95	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.96258130
96	ETV1_20927104_ChIP-Seq_GIST48_Human	0.95007445
97	NANOG_20526341_ChIP-Seq_ESCs_Human	0.94957669
98	ERG_20517297_ChIP-Seq_VCAP_Human	0.94702141
99	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.93501278
100	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.93456207

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.77031012
2	MP0006292_abnormal_olfactory_placode	4.17248414
3	MP0002653_abnormal_ependyma_morphology	2.90868861
4	MP0008877_abnormal_DNA_methylation	2.58833789
5	MP0003787_abnormal_imprinting	2.50189212
6	MP0002837_dystrophic_cardiac_calcinosis	2.20795169
7	MP0001485_abnormal_pinna_reflex	2.17404973
8	MP0004885_abnormal_endolymph	2.10990865
9	MP0002638_abnormal_pupillary_reflex	2.01423278
10	MP0000566_synostosis	2.01096214
11	MP0005551_abnormal_eye_electrophysiolog	1.98268130
12	MP0003136_yellow_coat_color	1.96647874
13	MP0004142_abnormal_muscle_tone	1.89861830
14	MP0003195_calcinosis	1.76846438
15	MP0006276_abnormal_autonomic_nervous	1.74173856
16	MP0003122_maternal_imprinting	1.74105598
17	MP0008789_abnormal_olfactory_epithelium	1.71611103
18	MP0005367_renal/urinary_system_phenotyp	1.59398207
19	MP0000516_abnormal_urinary_system	1.59398207
20	MP0003121_genomic_imprinting	1.59166885
21	MP0001968_abnormal_touch/_nociception	1.57678222
22	MP0000372_irregular_coat_pigmentation	1.56334829
23	MP0002138_abnormal_hepatobiliary_system	1.54010066
24	MP0008875_abnormal_xenobiotic_pharmacok	1.52525973
25	MP0003646_muscle_fatigue	1.51370074
26	MP0001529_abnormal_vocalization	1.50626121
27	MP0002272_abnormal_nervous_system	1.45940980
28	MP0004145_abnormal_muscle_electrophysio	1.45599770
29	MP0000631_abnormal_neuroendocrine_gland	1.45184166
30	MP0006072_abnormal_retinal_apoptosis	1.45095942
31	MP0002938_white_spotting	1.42332242
32	MP0001486_abnormal_startle_reflex	1.42328510
33	MP0005084_abnormal_gallbladder_morpholo	1.40089811
34	MP0003567_abnormal_fetal_cardiomyocyte	1.39636893
35	MP0003880_abnormal_central_pattern	1.37829299
36	MP0005174_abnormal_tail_pigmentation	1.35766759
37	MP0008872_abnormal_physiological_respon	1.35450592
38	MP0001905_abnormal_dopamine_level	1.32431340
39	MP0002102_abnormal_ear_morphology	1.30677722
40	MP0001984_abnormal_olfaction	1.30502900
41	MP0002736_abnormal_nociception_after	1.30206447
42	MP0001501_abnormal_sleep_pattern	1.28988765
43	MP0001293_anophthalmia	1.28611743
44	MP0002572_abnormal_emotion/affect_behav	1.28529764
45	MP0005394_taste/olfaction_phenotype	1.28480183
46	MP0005499_abnormal_olfactory_system	1.28480183
47	MP0005671_abnormal_response_to	1.28183478
48	MP0004147_increased_porphyrin_level	1.25701939
49	MP0002735_abnormal_chemical_nociception	1.24596714
50	MP0000778_abnormal_nervous_system	1.20022745
51	MP0005377_hearing/vestibular/ear_phenot	1.18255594
52	MP0003878_abnormal_ear_physiology	1.18255594
53	MP0004043_abnormal_pH_regulation	1.17289397
54	MP0004742_abnormal_vestibular_system	1.15282375
55	MP0001188_hyperpigmentation	1.14946164
56	MP0002095_abnormal_skin_pigmentation	1.12442192
57	MP0002234_abnormal_pharynx_morphology	1.10359874
58	MP0009745_abnormal_behavioral_response	1.09734338
59	MP0000049_abnormal_middle_ear	1.09086062
60	MP0002163_abnormal_gland_morphology	1.08785338
61	MP0005253_abnormal_eye_physiology	1.08263979
62	MP0005195_abnormal_posterior_eye	1.05272648
63	MP0000026_abnormal_inner_ear	1.04754609
64	MP0009046_muscle_twitch	1.04641677
65	MP0001970_abnormal_pain_threshold	1.04520908
66	MP0000569_abnormal_digit_pigmentation	1.03221004
67	MP0004133_heterotaxia	1.02130195
68	MP0001963_abnormal_hearing_physiology	1.00148670
69	MP0002277_abnormal_respiratory_mucosa	0.99729839
70	MP0002557_abnormal_social/conspecific_i	0.97484146
71	MP0002160_abnormal_reproductive_system	0.97368084
72	MP0002210_abnormal_sex_determination	0.97182602
73	MP0005389_reproductive_system_phenotype	0.96581486
74	MP0001764_abnormal_homeostasis	0.93574199
75	MP0002752_abnormal_somatic_nervous	0.90534829
76	MP0005646_abnormal_pituitary_gland	0.89738531
77	MP0001986_abnormal_taste_sensitivity	0.88654541
78	MP0002067_abnormal_sensory_capabilities	0.87389809
79	MP0000427_abnormal_hair_cycle	0.85586467
80	MP0005645_abnormal_hypothalamus_physiol	0.85576847
81	MP0001929_abnormal_gametogenesis	0.84108011
82	MP0002282_abnormal_trachea_morphology	0.83139799
83	MP0001919_abnormal_reproductive_system	0.82363830
84	MP0002733_abnormal_thermal_nociception	0.82348246
85	MP0002184_abnormal_innervation	0.82086663
86	MP0003011_delayed_dark_adaptation	0.81777968
87	MP0001145_abnormal_male_reproductive	0.80570737
88	MP0002063_abnormal_learning/memory/cond	0.80064039
89	MP0008995_early_reproductive_senescence	0.79668344
90	MP0002876_abnormal_thyroid_physiology	0.79341507
91	MP0005075_abnormal_melanosome_morpholog	0.79084389
92	MP0001835_abnormal_antigen_presentation	0.78842028
93	MP0009764_decreased_sensitivity_to	0.78304531
94	MP0003698_abnormal_male_reproductive	0.77635244
95	MP0001440_abnormal_grooming_behavior	0.76923656
96	MP0000653_abnormal_sex_gland	0.75621936
97	MP0006036_abnormal_mitochondrial_physio	0.75147631
98	MP0005410_abnormal_fertilization	0.74876008
99	MP0003635_abnormal_synaptic_transmissio	0.74821206
100	MP0003137_abnormal_impulse_conducting	0.74480373

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.06856145
2	Pancreatic fibrosis (HP:0100732)	3.96867438
3	Molar tooth sign on MRI (HP:0002419)	3.94251929
4	Abnormality of midbrain morphology (HP:0002418)	3.94251929
5	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.87584083
6	Absent/shortened dynein arms (HP:0200106)	3.85126858
7	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.85126858
8	Pancreatic cysts (HP:0001737)	3.82885512
9	Mitochondrial inheritance (HP:0001427)	3.76471801
10	Acute encephalopathy (HP:0006846)	3.50903832
11	True hermaphroditism (HP:0010459)	3.50090180
12	Abnormal mitochondria in muscle tissue (HP:0008316)	3.44689368
13	Progressive macrocephaly (HP:0004481)	3.27995755
14	Hyperventilation (HP:0002883)	3.26756206
15	Nephronophthisis (HP:0000090)	3.25227827
16	Lipid accumulation in hepatocytes (HP:0006561)	3.25225158
17	Reticulocytopenia (HP:0001896)	3.24595233
18	Abnormal rod and cone electroretinograms (HP:0008323)	3.23940156
19	Increased CSF lactate (HP:0002490)	3.22074227
20	Increased hepatocellular lipid droplets (HP:0006565)	3.14292555
21	Hepatocellular necrosis (HP:0001404)	3.11932702
22	Chronic hepatic failure (HP:0100626)	3.05761870
23	Abnormality of cells of the erythroid lineage (HP:0012130)	2.89588831
24	Abnormal respiratory epithelium morphology (HP:0012253)	2.88540891
25	Abnormal respiratory motile cilium morphology (HP:0005938)	2.88540891
26	Cerebral edema (HP:0002181)	2.86679640
27	Medial flaring of the eyebrow (HP:0010747)	2.86210911
28	Methylmalonic aciduria (HP:0012120)	2.81516216
29	Septo-optic dysplasia (HP:0100842)	2.76386534
30	Abnormal ciliary motility (HP:0012262)	2.76204415
31	Abnormality of the renal medulla (HP:0100957)	2.75926683
32	Hepatic necrosis (HP:0002605)	2.74141922
33	Congenital stationary night blindness (HP:0007642)	2.70119169
34	Sclerocornea (HP:0000647)	2.55729667
35	Rib fusion (HP:0000902)	2.55581823
36	Gait imbalance (HP:0002141)	2.52098380
37	Optic disc pallor (HP:0000543)	2.51437338
38	Cystic liver disease (HP:0006706)	2.51225836
39	Abnormal number of erythroid precursors (HP:0012131)	2.50698173
40	Abnormal respiratory motile cilium physiology (HP:0012261)	2.50072738
41	Congenital primary aphakia (HP:0007707)	2.49070983
42	Renal Fanconi syndrome (HP:0001994)	2.47934375
43	Abnormality of DNA repair (HP:0003254)	2.43779245
44	Methylmalonic acidemia (HP:0002912)	2.37689376
45	Macrocytic anemia (HP:0001972)	2.31302419
46	Decreased central vision (HP:0007663)	2.27808011
47	Abnormality of the renal cortex (HP:0011035)	2.25587537
48	3-Methylglutaconic aciduria (HP:0003535)	2.24252803
49	Nephrogenic diabetes insipidus (HP:0009806)	2.24215613
50	Attenuation of retinal blood vessels (HP:0007843)	2.21618042
51	Hyperglycinemia (HP:0002154)	2.20794835
52	Absent thumb (HP:0009777)	2.17120484
53	Type II lissencephaly (HP:0007260)	2.16655781
54	Supernumerary spleens (HP:0009799)	2.16583545
55	Exertional dyspnea (HP:0002875)	2.16469825
56	Male pseudohermaphroditism (HP:0000037)	2.12759797
57	Lactic acidosis (HP:0003128)	2.12672035
58	Increased serum lactate (HP:0002151)	2.12060413
59	Pallor (HP:0000980)	2.11463720
60	Abnormality of the labia minora (HP:0012880)	2.10098393
61	Abnormality of urine glucose concentration (HP:0011016)	2.07697380
62	Glycosuria (HP:0003076)	2.07697380
63	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.07266360
64	Increased intramyocellular lipid droplets (HP:0012240)	2.07259083
65	Optic nerve hypoplasia (HP:0000609)	2.04319534
66	Abolished electroretinogram (ERG) (HP:0000550)	2.02652819
67	Triphalangeal thumb (HP:0001199)	2.01555344
68	Postaxial foot polydactyly (HP:0001830)	2.00035049
69	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.99917832
70	Volvulus (HP:0002580)	1.95069806
71	Lethargy (HP:0001254)	1.94616996
72	Vaginal atresia (HP:0000148)	1.94501297
73	Abnormality of renal resorption (HP:0011038)	1.93373802
74	Genital tract atresia (HP:0001827)	1.93358168
75	Abnormality of alanine metabolism (HP:0010916)	1.91063299
76	Hyperalaninemia (HP:0003348)	1.91063299
77	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.91063299
78	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.91034860
79	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.89226843
80	Congenital, generalized hypertrichosis (HP:0004540)	1.88022278
81	Increased muscle lipid content (HP:0009058)	1.87709361
82	Colon cancer (HP:0003003)	1.85105850
83	Congenital hepatic fibrosis (HP:0002612)	1.83869218
84	Intestinal atresia (HP:0011100)	1.82742456
85	Anencephaly (HP:0002323)	1.82632885
86	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.82174288
87	Asplenia (HP:0001746)	1.81873800
88	Respiratory failure (HP:0002878)	1.78586674
89	Oligodactyly (hands) (HP:0001180)	1.75547000
90	Hyperphosphaturia (HP:0003109)	1.74857965
91	Febrile seizures (HP:0002373)	1.74648384
92	Abnormal biliary tract physiology (HP:0012439)	1.73752136
93	Bile duct proliferation (HP:0001408)	1.73752136
94	Leukodystrophy (HP:0002415)	1.73468418
95	Renal cortical cysts (HP:0000803)	1.72967500
96	Poor coordination (HP:0002370)	1.72924250
97	Constricted visual fields (HP:0001133)	1.72905710
98	Confusion (HP:0001289)	1.71928244
99	Focal motor seizures (HP:0011153)	1.71182112
100	Postaxial hand polydactyly (HP:0001162)	1.69974987

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	3.03540793
2	PASK	2.87760966
3	FRK	2.52599929
4	WNK3	2.46210670
5	GRK1	2.36515034
6	MAP3K12	2.33130066
7	TXK	2.29719541
8	MAP4K2	2.28078618
9	ADRBK2	2.26367115
10	ZAK	2.16526948
11	TLK1	2.14272355
12	CDK19	2.08943848
13	MAP3K4	2.00397076
14	WNK4	1.88648329
15	NEK1	1.71524727
16	MAPK13	1.70596866
17	VRK2	1.64622013
18	NUAK1	1.62108640
19	DYRK2	1.60538181
20	PINK1	1.56224593
21	VRK1	1.54422573
22	TAF1	1.50797589
23	TRIM28	1.38381529
24	STK16	1.36447744
25	PLK4	1.33051728
26	TAOK3	1.31339238
27	CDK8	1.31334176
28	CSNK1G2	1.30279800
29	CSNK1G3	1.28898050
30	BMPR1B	1.28844009
31	KDR	1.22331276
32	CASK	1.22043814
33	CSNK1G1	1.14372364
34	CDC7	1.08295291
35	CSNK1A1L	1.06981674
36	CAMKK1	1.06560528
37	DYRK1A	1.03527081
38	INSRR	1.01978925
39	TEC	0.98241067
40	OXSR1	0.96403059
41	NME1	0.85647197
42	MKNK2	0.82567474
43	TIE1	0.80226311
44	CAMKK2	0.79314585
45	PRKCG	0.79060733
46	IKBKB	0.77970726
47	NEK2	0.75918650
48	NTRK2	0.74564945
49	STK39	0.69616635
50	PIK3CA	0.69413487
51	ERBB3	0.68800251
52	TNIK	0.68074785
53	PRKCQ	0.67828817
54	RPS6KA5	0.67422685
55	PKN1	0.67164774
56	ITK	0.66742357
57	MKNK1	0.66342080
58	CDK3	0.64908441
59	MARK1	0.64568288
60	LIMK1	0.63386129
61	PNCK	0.62509877
62	MAP2K7	0.61405816
63	SYK	0.61389525
64	ADRBK1	0.61049693
65	OBSCN	0.60592740
66	BUB1	0.59600990
67	TGFBR1	0.59160898
68	STK11	0.57921402
69	DAPK2	0.57070886
70	CAMK1	0.55185030
71	PRKCE	0.53056075
72	BTK	0.53022809
73	PAK3	0.52626251
74	CSNK2A2	0.52545018
75	ATR	0.51973390
76	MARK3	0.51290931
77	PRKACA	0.50795664
78	KIT	0.50155610
79	MATK	0.49732281
80	AURKB	0.48624977
81	DAPK3	0.47967310
82	MAP3K11	0.46780028
83	MINK1	0.46297337
84	MYLK	0.45636181
85	ACVR1B	0.45179921
86	MST4	0.45001285
87	PIK3CG	0.44791007
88	CHEK2	0.44418924
89	CSNK1A1	0.44399942
90	CCNB1	0.44210603
91	MUSK	0.42703868
92	PRKG1	0.41597962
93	PHKG1	0.41528085
94	PHKG2	0.41528085
95	MAPK15	0.41384553
96	GRK7	0.41032631
97	CAMK2A	0.41026493
98	PRKCA	0.40549714
99	LYN	0.39018741
100	DAPK1	0.38947662

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.61256335
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.63226388
3	Parkinsons disease_Homo sapiens_hsa05012	3.04413891
4	Asthma_Homo sapiens_hsa05310	3.02115718
5	Propanoate metabolism_Homo sapiens_hsa00640	2.25026253
6	Huntingtons disease_Homo sapiens_hsa05016	2.11889055
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.07368396
8	Protein export_Homo sapiens_hsa03060	2.06975681
9	Proteasome_Homo sapiens_hsa03050	2.05740081
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.01154773
11	Cardiac muscle contraction_Homo sapiens_hsa04260	1.98153224
12	Alzheimers disease_Homo sapiens_hsa05010	1.94121211
13	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.93108911
14	Allograft rejection_Homo sapiens_hsa05330	1.90838254
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.89528234
16	RNA polymerase_Homo sapiens_hsa03020	1.85749276
17	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.84572310
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.83105700
19	Graft-versus-host disease_Homo sapiens_hsa05332	1.80205437
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.79466368
21	Type I diabetes mellitus_Homo sapiens_hsa04940	1.60716722
22	RNA degradation_Homo sapiens_hsa03018	1.60397224
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.51794703
24	Homologous recombination_Homo sapiens_hsa03440	1.50049410
25	Phototransduction_Homo sapiens_hsa04744	1.48313079
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.46073578
27	Butanoate metabolism_Homo sapiens_hsa00650	1.46021879
28	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.45705227
29	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.43120041
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.35221936
31	Nicotine addiction_Homo sapiens_hsa05033	1.31934776
32	Basal transcription factors_Homo sapiens_hsa03022	1.27975474
33	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.26300249
34	Taste transduction_Homo sapiens_hsa04742	1.20583385
35	Tryptophan metabolism_Homo sapiens_hsa00380	1.18297169
36	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.17226972
37	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.12496127
38	Nucleotide excision repair_Homo sapiens_hsa03420	1.07648466
39	Nitrogen metabolism_Homo sapiens_hsa00910	1.07090338
40	Olfactory transduction_Homo sapiens_hsa04740	1.06303805
41	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.99137678
42	Peroxisome_Homo sapiens_hsa04146	0.97426345
43	Caffeine metabolism_Homo sapiens_hsa00232	0.97235530
44	Ether lipid metabolism_Homo sapiens_hsa00565	0.96581337
45	Base excision repair_Homo sapiens_hsa03410	0.95224028
46	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.95099950
47	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.93630577
48	Rheumatoid arthritis_Homo sapiens_hsa05323	0.91312088
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.91102531
50	Fat digestion and absorption_Homo sapiens_hsa04975	0.90392044
51	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.89573676
52	Antigen processing and presentation_Homo sapiens_hsa04612	0.89281529
53	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.89236844
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.88158756
55	Retinol metabolism_Homo sapiens_hsa00830	0.87724280
56	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.87533408
57	Primary immunodeficiency_Homo sapiens_hsa05340	0.83800533
58	Pyrimidine metabolism_Homo sapiens_hsa00240	0.83571709
59	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.81499151
60	Purine metabolism_Homo sapiens_hsa00230	0.81068667
61	Morphine addiction_Homo sapiens_hsa05032	0.76787328
62	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.75532742
63	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.72965444
64	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.70363694
65	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.68844418
66	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.68604801
67	Pyruvate metabolism_Homo sapiens_hsa00620	0.66610383
68	One carbon pool by folate_Homo sapiens_hsa00670	0.65225584
69	Metabolic pathways_Homo sapiens_hsa01100	0.64949820
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.63924054
71	beta-Alanine metabolism_Homo sapiens_hsa00410	0.57611351
72	Mismatch repair_Homo sapiens_hsa03430	0.57436101
73	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.55450855
74	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.54774727
75	Glycerolipid metabolism_Homo sapiens_hsa00561	0.53860428
76	DNA replication_Homo sapiens_hsa03030	0.53558033
77	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.52000251
78	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.51323280
79	Viral myocarditis_Homo sapiens_hsa05416	0.50356212
80	RNA transport_Homo sapiens_hsa03013	0.44007444
81	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.42839489
82	Fatty acid degradation_Homo sapiens_hsa00071	0.42780490
83	Serotonergic synapse_Homo sapiens_hsa04726	0.39391273
84	GABAergic synapse_Homo sapiens_hsa04727	0.38918113
85	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.38485576
86	Steroid biosynthesis_Homo sapiens_hsa00100	0.37979204
87	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.35667023
88	Insulin secretion_Homo sapiens_hsa04911	0.35499274
89	Collecting duct acid secretion_Homo sapiens_hsa04966	0.34994699
90	Glutamatergic synapse_Homo sapiens_hsa04724	0.33010880
91	Spliceosome_Homo sapiens_hsa03040	0.32189694
92	Histidine metabolism_Homo sapiens_hsa00340	0.31770249
93	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.29754628
94	Salivary secretion_Homo sapiens_hsa04970	0.28805125
95	Regulation of autophagy_Homo sapiens_hsa04140	0.26524740
96	Glutathione metabolism_Homo sapiens_hsa00480	0.25533677
97	Sulfur metabolism_Homo sapiens_hsa00920	0.25268367
98	Alcoholism_Homo sapiens_hsa05034	0.25137204
99	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.24883818
100	Circadian entrainment_Homo sapiens_hsa04713	0.23817181

RPL5P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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