ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.43532666
2	ribosomal small subunit assembly (GO:0000028)	5.62475738
3	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.46804398
4	cytidine metabolic process (GO:0046087)	4.92907226
5	cytidine catabolic process (GO:0006216)	4.92907226
6	cytidine deamination (GO:0009972)	4.92907226
7	viral transcription (GO:0019083)	4.82337573
8	translational termination (GO:0006415)	4.63879917
9	protein neddylation (GO:0045116)	4.44727642
10	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.23588482
11	translational elongation (GO:0006414)	4.15197816
12	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.07490302
13	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.04928721
14	cotranslational protein targeting to membrane (GO:0006613)	3.99322078
15	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.97647258
16	ATP synthesis coupled proton transport (GO:0015986)	3.97647258
17	protein targeting to ER (GO:0045047)	3.96205856
18	protein localization to endoplasmic reticulum (GO:0070972)	3.75959881
19	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.73573652
20	ribosomal large subunit biogenesis (GO:0042273)	3.69744043
21	chaperone-mediated protein transport (GO:0072321)	3.49878351
22	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.47209419
23	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.47209419
24	regulation of isotype switching to IgG isotypes (GO:0048302)	3.46010558
25	cellular protein complex disassembly (GO:0043624)	3.40490024
26	viral life cycle (GO:0019058)	3.38057110
27	ribosomal small subunit biogenesis (GO:0042274)	3.26665240
28	protein complex biogenesis (GO:0070271)	3.26240199
29	positive regulation of interleukin-17 production (GO:0032740)	3.20734732
30	iron-sulfur cluster assembly (GO:0016226)	3.20580560
31	metallo-sulfur cluster assembly (GO:0031163)	3.20580560
32	translational initiation (GO:0006413)	3.16662171
33	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.07470083
34	kynurenine metabolic process (GO:0070189)	3.06668046
35	positive regulation of alpha-beta T cell proliferation (GO:0046641)	3.04887479
36	sequestering of actin monomers (GO:0042989)	3.03916294
37	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.01622729
38	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.01622729
39	NADH dehydrogenase complex assembly (GO:0010257)	3.01622729
40	maturation of SSU-rRNA (GO:0030490)	2.99953574
41	purine deoxyribonucleotide catabolic process (GO:0009155)	2.97229960
42	indole-containing compound catabolic process (GO:0042436)	2.96909893
43	indolalkylamine catabolic process (GO:0046218)	2.96909893
44	tryptophan catabolic process (GO:0006569)	2.96909893
45	behavioral response to nicotine (GO:0035095)	2.96498823
46	response to pheromone (GO:0019236)	2.96252669
47	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.93626621
48	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.92291106
49	positive regulation of B cell differentiation (GO:0045579)	2.89466117
50	mitochondrial respiratory chain complex assembly (GO:0033108)	2.87778458
51	water-soluble vitamin biosynthetic process (GO:0042364)	2.87680204
52	actin nucleation (GO:0045010)	2.85735998
53	regulation of regulatory T cell differentiation (GO:0045589)	2.80998446
54	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.80279755
55	cellular anion homeostasis (GO:0030002)	2.79462637
56	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.79360152
57	translation (GO:0006412)	2.79236758
58	positive regulation of defense response to virus by host (GO:0002230)	2.75819526
59	indolalkylamine metabolic process (GO:0006586)	2.73614494
60	ubiquinone biosynthetic process (GO:0006744)	2.73326649
61	regulation of memory T cell differentiation (GO:0043380)	2.73264025
62	negative regulation of T cell apoptotic process (GO:0070233)	2.69938016
63	protein complex disassembly (GO:0043241)	2.67959727
64	forebrain morphogenesis (GO:0048853)	2.65893123
65	positive regulation of T cell apoptotic process (GO:0070234)	2.65604655
66	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.65122602
67	base-excision repair, AP site formation (GO:0006285)	2.63782869
68	negative T cell selection (GO:0043383)	2.63571284
69	cellular ketone body metabolic process (GO:0046950)	2.63359875
70	electron transport chain (GO:0022900)	2.62708032
71	respiratory electron transport chain (GO:0022904)	2.61894026
72	positive regulation of calcium-mediated signaling (GO:0050850)	2.60576005
73	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.57649225
74	negative regulation of mast cell activation (GO:0033004)	2.55802847
75	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.55754512
76	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.55528682
77	termination of RNA polymerase III transcription (GO:0006386)	2.55528682
78	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.55337662
79	macromolecular complex disassembly (GO:0032984)	2.54611480
80	negative regulation of multicellular organism growth (GO:0040015)	2.54280923
81	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.53327744
82	platelet dense granule organization (GO:0060155)	2.53143197
83	deoxyribonucleotide catabolic process (GO:0009264)	2.53093047
84	positive thymic T cell selection (GO:0045059)	2.52412913
85	ATP biosynthetic process (GO:0006754)	2.50245148
86	tryptophan metabolic process (GO:0006568)	2.49969554
87	DNA demethylation (GO:0080111)	2.49925038
88	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.49550597
89	regulation of alpha-beta T cell proliferation (GO:0046640)	2.48346281
90	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.48258087
91	GTP biosynthetic process (GO:0006183)	2.47351183
92	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.46936869
93	respiratory chain complex IV assembly (GO:0008535)	2.46179042
94	protein targeting to membrane (GO:0006612)	2.43849173
95	cellular component biogenesis (GO:0044085)	2.43012971
96	deoxyribose phosphate catabolic process (GO:0046386)	2.42815286
97	ubiquinone metabolic process (GO:0006743)	2.42668338
98	regulation of action potential (GO:0098900)	2.42409233
99	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.42112310
100	cytochrome complex assembly (GO:0017004)	2.40751323

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.67203787
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.65116110
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.64704279
4	VDR_22108803_ChIP-Seq_LS180_Human	3.03160819
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.65972078
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.63764579
7	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.58386431
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.42978488
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.40519081
10	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.18353040
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.17194316
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.03339314
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.95792469
14	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.93059298
15	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.85877703
16	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.81263142
17	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.79761844
18	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.79060997
19	VDR_23849224_ChIP-Seq_CD4+_Human	1.76428448
20	FUS_26573619_Chip-Seq_HEK293_Human	1.74136628
21	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.72728451
22	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.72085173
23	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.70739035
24	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.68887997
25	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.67856947
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.64325288
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.63740304
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.60959606
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.59268899
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.57115741
31	EWS_26573619_Chip-Seq_HEK293_Human	1.55794054
32	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.53935346
33	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.53935346
34	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.51839328
35	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.46348990
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.44616281
37	TAF2_19829295_ChIP-Seq_ESCs_Human	1.43994927
38	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.42407916
39	NCOR_22424771_ChIP-Seq_293T_Human	1.41486232
40	AR_20517297_ChIP-Seq_VCAP_Human	1.39007217
41	GBX2_23144817_ChIP-Seq_PC3_Human	1.37811831
42	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.34290491
43	TAF15_26573619_Chip-Seq_HEK293_Human	1.34006865
44	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.33318854
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.32427828
46	NANOG_20526341_ChIP-Seq_ESCs_Human	1.32189328
47	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.30781890
48	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.30175007
49	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.28971978
50	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.27956922
51	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.27800809
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.25785323
53	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.25785323
54	P300_19829295_ChIP-Seq_ESCs_Human	1.25409082
55	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.24045435
56	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.23408932
57	FOXP3_21729870_ChIP-Seq_TREG_Human	1.23008982
58	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.21484776
59	MYB_26560356_Chip-Seq_TH2_Human	1.21358721
60	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.20509067
61	ELK1_19687146_ChIP-ChIP_HELA_Human	1.19702900
62	GATA3_26560356_Chip-Seq_TH2_Human	1.19415467
63	HTT_18923047_ChIP-ChIP_STHdh_Human	1.19092232
64	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.19047524
65	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.18749392
66	RNF2_27304074_Chip-Seq_NSC_Mouse	1.18555683
67	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.18376162
68	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.17574450
69	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.17513730
70	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.16507737
71	GATA3_27048872_Chip-Seq_THYMUS_Human	1.16106837
72	ERG_20517297_ChIP-Seq_VCAP_Human	1.15957395
73	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.13316985
74	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.13097679
75	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.13070512
76	RUNX_20019798_ChIP-Seq_JUKART_Human	1.12893260
77	SOX2_19829295_ChIP-Seq_ESCs_Human	1.11804850
78	NANOG_19829295_ChIP-Seq_ESCs_Human	1.11804850
79	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.10309773
80	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10255170
81	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.09906003
82	MYC_19829295_ChIP-Seq_ESCs_Human	1.08557061
83	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.07096421
84	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.06896114
85	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.05881705
86	P53_21459846_ChIP-Seq_SAOS-2_Human	1.04400872
87	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.04274722
88	BCAT_22108803_ChIP-Seq_LS180_Human	1.04272128
89	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.03861544
90	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.03149218
91	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.01682946
92	IRF1_19129219_ChIP-ChIP_H3396_Human	1.00012968
93	ERA_21632823_ChIP-Seq_H3396_Human	0.98966654
94	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98759251
95	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.97941298
96	PHF8_20622853_ChIP-Seq_HELA_Human	0.96083906
97	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.94806615
98	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.94150689
99	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.93355396
100	OCT4_20526341_ChIP-Seq_ESCs_Human	0.92777804

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.28729101
2	MP0002837_dystrophic_cardiac_calcinosis	3.22239236
3	MP0009379_abnormal_foot_pigmentation	3.07162640
4	MP0006292_abnormal_olfactory_placode	2.99263365
5	MP0002163_abnormal_gland_morphology	2.74234076
6	MP0002653_abnormal_ependyma_morphology	2.55632424
7	MP0003646_muscle_fatigue	2.46782849
8	MP0001873_stomach_inflammation	2.39716256
9	MP0003011_delayed_dark_adaptation	2.24557797
10	MP0002234_abnormal_pharynx_morphology	2.22922755
11	MP0001835_abnormal_antigen_presentation	2.18271410
12	MP0002102_abnormal_ear_morphology	1.99372035
13	MP0000372_irregular_coat_pigmentation	1.97500505
14	MP0005379_endocrine/exocrine_gland_phen	1.88751459
15	MP0005551_abnormal_eye_electrophysiolog	1.87792008
16	MP0005646_abnormal_pituitary_gland	1.84679265
17	MP0008872_abnormal_physiological_respon	1.78198039
18	MP0002160_abnormal_reproductive_system	1.77398078
19	MP0009785_altered_susceptibility_to	1.76278425
20	MP0005645_abnormal_hypothalamus_physiol	1.75105646
21	MP0008875_abnormal_xenobiotic_pharmacok	1.73032020
22	MP0001968_abnormal_touch/_nociception	1.68716519
23	MP0006072_abnormal_retinal_apoptosis	1.65269998
24	MP0005084_abnormal_gallbladder_morpholo	1.56297947
25	MP0001986_abnormal_taste_sensitivity	1.56084779
26	MP0005389_reproductive_system_phenotype	1.54437086
27	MP0001800_abnormal_humoral_immune	1.50690942
28	MP0002736_abnormal_nociception_after	1.47425355
29	MP0002166_altered_tumor_susceptibility	1.42734722
30	MP0002822_catalepsy	1.42416495
31	MP0003195_calcinosis	1.41676797
32	MP0005075_abnormal_melanosome_morpholog	1.40389988
33	MP0003763_abnormal_thymus_physiology	1.40265669
34	MP0004147_increased_porphyrin_level	1.38859155
35	MP0002148_abnormal_hypersensitivity_rea	1.33554805
36	MP0001905_abnormal_dopamine_level	1.32834391
37	MP0008877_abnormal_DNA_methylation	1.32435056
38	MP0002638_abnormal_pupillary_reflex	1.30785451
39	MP0001764_abnormal_homeostasis	1.28926999
40	MP0002876_abnormal_thyroid_physiology	1.28776180
41	MP0005000_abnormal_immune_tolerance	1.27095927
42	MP0002006_tumorigenesis	1.26897417
43	MP0009333_abnormal_splenocyte_physiolog	1.26563698
44	MP0005253_abnormal_eye_physiology	1.26408234
45	MP0002138_abnormal_hepatobiliary_system	1.24246841
46	MP0004782_abnormal_surfactant_physiolog	1.23560164
47	MP0003252_abnormal_bile_duct	1.22769441
48	MP0006276_abnormal_autonomic_nervous	1.21126875
49	MP0002723_abnormal_immune_serum	1.20122846
50	MP0005025_abnormal_response_to	1.19693090
51	MP0002693_abnormal_pancreas_physiology	1.18395554
52	MP0006082_CNS_inflammation	1.18060927
53	MP0002420_abnormal_adaptive_immunity	1.12666832
54	MP0003880_abnormal_central_pattern	1.10789318
55	MP0001819_abnormal_immune_cell	1.08549301
56	MP0002272_abnormal_nervous_system	1.06823468
57	MP0004145_abnormal_muscle_electrophysio	1.06637327
58	MP0009745_abnormal_behavioral_response	1.04219943
59	MP0005387_immune_system_phenotype	1.02535910
60	MP0001790_abnormal_immune_system	1.02535910
61	MP0000631_abnormal_neuroendocrine_gland	0.99904984
62	MP0004142_abnormal_muscle_tone	0.99098796
63	MP0001919_abnormal_reproductive_system	0.97660231
64	MP0005410_abnormal_fertilization	0.97323533
65	MP0001664_abnormal_digestion	0.97024470
66	MP0004885_abnormal_endolymph	0.96425080
67	MP0000049_abnormal_middle_ear	0.94967491
68	MP0001188_hyperpigmentation	0.94634599
69	MP0004130_abnormal_muscle_cell	0.94457382
70	MP0003878_abnormal_ear_physiology	0.94185677
71	MP0005377_hearing/vestibular/ear_phenot	0.94185677
72	MP0002405_respiratory_system_inflammati	0.93065607
73	MP0003866_abnormal_defecation	0.91837874
74	MP0002452_abnormal_antigen_presenting	0.90995274
75	MP0000689_abnormal_spleen_morphology	0.90505555
76	MP0008789_abnormal_olfactory_epithelium	0.90483933
77	MP0000685_abnormal_immune_system	0.89639573
78	MP0003787_abnormal_imprinting	0.88320321
79	MP0000716_abnormal_immune_system	0.87900624
80	MP0000678_abnormal_parathyroid_gland	0.85851066
81	MP0002398_abnormal_bone_marrow	0.85535108
82	MP0001501_abnormal_sleep_pattern	0.83994951
83	MP0010155_abnormal_intestine_physiology	0.83832882
84	MP0001485_abnormal_pinna_reflex	0.83016665
85	MP0003137_abnormal_impulse_conducting	0.81218103
86	MP0005636_abnormal_mineral_homeostasis	0.80026942
87	MP0002933_joint_inflammation	0.79914100
88	MP0001440_abnormal_grooming_behavior	0.78620332
89	MP0008995_early_reproductive_senescence	0.77298231
90	MP0002722_abnormal_immune_system	0.76712771
91	MP0009764_decreased_sensitivity_to	0.76224733
92	MP0006054_spinal_hemorrhage	0.75320590
93	MP0000703_abnormal_thymus_morphology	0.74940751
94	MP0003283_abnormal_digestive_organ	0.74792567
95	MP0002277_abnormal_respiratory_mucosa	0.74590281
96	MP0002132_abnormal_respiratory_system	0.73945168
97	MP0002733_abnormal_thermal_nociception	0.73646320
98	MP0001845_abnormal_inflammatory_respons	0.72145700
99	MP0003567_abnormal_fetal_cardiomyocyte	0.70458652
100	MP0001348_abnormal_lacrimal_gland	0.70360568

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased IgM level (HP:0003496)	4.15420953
2	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.86470899
3	Congenital stationary night blindness (HP:0007642)	3.75827202
4	Severe combined immunodeficiency (HP:0004430)	3.63185547
5	Autoimmune hemolytic anemia (HP:0001890)	3.61483553
6	Autoimmune thrombocytopenia (HP:0001973)	3.59848743
7	Elevated erythrocyte sedimentation rate (HP:0003565)	3.47299205
8	Mitochondrial inheritance (HP:0001427)	3.47100336
9	Abnormality of T cell number (HP:0011839)	3.36142003
10	Renal Fanconi syndrome (HP:0001994)	3.33333389
11	Abnormal delayed hypersensitivity skin test (HP:0002963)	3.29686987
12	Abnormality of B cell number (HP:0010975)	3.26861942
13	Increased hepatocellular lipid droplets (HP:0006565)	3.25574597
14	Abnormal rod and cone electroretinograms (HP:0008323)	3.22167966
15	Acute necrotizing encephalopathy (HP:0006965)	3.18348785
16	Abnormality of eosinophils (HP:0001879)	3.13693668
17	Thyroiditis (HP:0100646)	3.06178928
18	Aplastic anemia (HP:0001915)	3.03288582
19	B lymphocytopenia (HP:0010976)	2.98280057
20	Hypoproteinemia (HP:0003075)	2.92274167
21	IgG deficiency (HP:0004315)	2.92072700
22	Increased CSF lactate (HP:0002490)	2.89470192
23	Hepatocellular necrosis (HP:0001404)	2.88856338
24	Abnormal mitochondria in muscle tissue (HP:0008316)	2.85776139
25	Pancreatic cysts (HP:0001737)	2.85387373
26	Lipid accumulation in hepatocytes (HP:0006561)	2.84247995
27	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.80782504
28	Absent/shortened dynein arms (HP:0200106)	2.80782504
29	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.78233188
30	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.78233188
31	Increased intramyocellular lipid droplets (HP:0012240)	2.77771260
32	Decreased central vision (HP:0007663)	2.75890330
33	Eosinophilia (HP:0001880)	2.75827098
34	Acute encephalopathy (HP:0006846)	2.74537938
35	Hepatic necrosis (HP:0002605)	2.71452843
36	Progressive macrocephaly (HP:0004481)	2.70601717
37	Molar tooth sign on MRI (HP:0002419)	2.68506617
38	Abnormality of midbrain morphology (HP:0002418)	2.68506617
39	Stomatitis (HP:0010280)	2.68263659
40	Combined immunodeficiency (HP:0005387)	2.67557750
41	Pancreatic fibrosis (HP:0100732)	2.62598200
42	Abnormality of T cells (HP:0002843)	2.58933842
43	Abnormality of cells of the erythroid lineage (HP:0012130)	2.58604437
44	Abolished electroretinogram (ERG) (HP:0000550)	2.58482056
45	True hermaphroditism (HP:0010459)	2.58040500
46	Panhypogammaglobulinemia (HP:0003139)	2.50016688
47	Exertional dyspnea (HP:0002875)	2.43602712
48	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.42928435
49	T lymphocytopenia (HP:0005403)	2.42610546
50	Pendular nystagmus (HP:0012043)	2.40841183
51	Abnormal number of erythroid precursors (HP:0012131)	2.39048069
52	Optic disc pallor (HP:0000543)	2.38256146
53	Renal cortical cysts (HP:0000803)	2.38180021
54	Attenuation of retinal blood vessels (HP:0007843)	2.35380566
55	Macrocytic anemia (HP:0001972)	2.30730521
56	Abnormality of urine glucose concentration (HP:0011016)	2.30287206
57	Glycosuria (HP:0003076)	2.30287206
58	Reticulocytopenia (HP:0001896)	2.21061159
59	3-Methylglutaconic aciduria (HP:0003535)	2.20556376
60	Cerebral edema (HP:0002181)	2.19913383
61	Abnormality of renal resorption (HP:0011038)	2.19161347
62	Stenosis of the external auditory canal (HP:0000402)	2.19152645
63	Abnormal drinking behavior (HP:0030082)	2.18840102
64	Polydipsia (HP:0001959)	2.18840102
65	Constricted visual fields (HP:0001133)	2.18527864
66	Abnormality of T cell physiology (HP:0011840)	2.18473759
67	Increased muscle lipid content (HP:0009058)	2.18443890
68	Abnormal respiratory epithelium morphology (HP:0012253)	2.17944639
69	Abnormal respiratory motile cilium morphology (HP:0005938)	2.17944639
70	Medial flaring of the eyebrow (HP:0010747)	2.14347853
71	Abnormality of the prostate (HP:0008775)	2.14036186
72	Agammaglobulinemia (HP:0004432)	2.11417090
73	Abnormality of the renal cortex (HP:0011035)	2.11182707
74	Hypochromic anemia (HP:0001931)	2.10450977
75	Granulocytopenia (HP:0001913)	2.10326996
76	Generalized aminoaciduria (HP:0002909)	2.09746007
77	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.09198999
78	Nephronophthisis (HP:0000090)	2.07248929
79	Abnormal ciliary motility (HP:0012262)	2.03419568
80	Lactic acidosis (HP:0003128)	2.01960846
81	Abnormality of macular pigmentation (HP:0008002)	2.00231707
82	Methylmalonic acidemia (HP:0002912)	1.99289397
83	Increased serum lactate (HP:0002151)	1.98971509
84	Leukocytosis (HP:0001974)	1.98149614
85	Pallor (HP:0000980)	1.97168651
86	Prostate neoplasm (HP:0100787)	1.96522134
87	Type 2 muscle fiber atrophy (HP:0003554)	1.95749537
88	Chronic hepatic failure (HP:0100626)	1.94222916
89	Ketosis (HP:0001946)	1.93159947
90	Lethargy (HP:0001254)	1.89977415
91	Abnormal respiratory motile cilium physiology (HP:0012261)	1.89314434
92	Encephalitis (HP:0002383)	1.89309801
93	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.87557081
94	Absent thumb (HP:0009777)	1.86958192
95	Hypergammaglobulinemia (HP:0010702)	1.86169496
96	Type II lissencephaly (HP:0007260)	1.85650154
97	Neutropenia (HP:0001875)	1.82788453
98	Hyperglycinemia (HP:0002154)	1.81737507
99	Abnormality of the renal collecting system (HP:0004742)	1.80957605
100	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.80379009

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	3.61153230
2	TLK1	3.51591761
3	BCKDK	3.45366548
4	CDK19	3.44247727
5	KDR	2.95641221
6	FRK	2.92623409
7	PASK	2.90211223
8	ADRBK2	2.60687705
9	MAP4K2	2.45750592
10	PIK3CA	2.31057204
11	GRK1	2.27063271
12	ZAK	2.20771474
13	TAOK3	2.18561268
14	KIT	1.88904360
15	TESK2	1.87190483
16	PINK1	1.80545567
17	OXSR1	1.64916872
18	VRK2	1.63160294
19	TIE1	1.51801855
20	TEC	1.50900701
21	MAP4K1	1.44367542
22	SCYL2	1.43538018
23	ITK	1.42680085
24	NUAK1	1.38800163
25	TNK2	1.31280139
26	SYK	1.30730093
27	WNK4	1.30555895
28	VRK1	1.28176355
29	FES	1.25675914
30	CAMKK1	1.15581513
31	WNK3	1.15337492
32	CAMKK2	1.14732584
33	BMPR1B	1.13111974
34	EIF2AK3	1.10754193
35	BTK	1.09024701
36	PRKCQ	1.06400194
37	LCK	1.00993602
38	INSRR	0.97218622
39	GRK7	0.94685143
40	MAP3K11	0.91519450
41	GRK6	0.91055483
42	LIMK1	0.87367627
43	STK16	0.84774644
44	MAPK13	0.82899552
45	CSNK1G1	0.79408298
46	IKBKB	0.77893682
47	CSNK1G3	0.77387914
48	MAP2K6	0.74245113
49	FLT3	0.74039008
50	ZAP70	0.72882530
51	DAPK2	0.71218391
52	DYRK2	0.71187165
53	BMPR2	0.69214907
54	ADRBK1	0.68466450
55	OBSCN	0.67446305
56	CSF1R	0.67063617
57	MUSK	0.64826066
58	STK39	0.63762405
59	JAK3	0.62803551
60	IKBKE	0.62148797
61	LYN	0.61575770
62	MAPKAPK3	0.61423353
63	RPS6KA5	0.60404690
64	RIPK4	0.58705606
65	MATK	0.54171293
66	PIM2	0.54083629
67	CSNK1G2	0.53297164
68	PRKCG	0.52738100
69	TESK1	0.51035932
70	PIM1	0.50774592
71	GRK5	0.49837641
72	PRKACA	0.49835727
73	DAPK1	0.47209333
74	PRKCA	0.46940370
75	IGF1R	0.46576893
76	PIK3CG	0.45766806
77	STK11	0.43552965
78	NLK	0.43430265
79	AURKA	0.39793449
80	TRIM28	0.38865738
81	RPS6KA4	0.38614087
82	CDK3	0.37054659
83	BUB1	0.36257700
84	PRKCE	0.36158944
85	CSK	0.35465032
86	CAMK1	0.33836770
87	CSNK1A1L	0.33132272
88	RPS6KB2	0.32796950
89	PRKCH	0.32446560
90	PRKCD	0.32222809
91	DAPK3	0.31944541
92	CSNK2A2	0.31668583
93	CSNK1A1	0.31555630
94	PLK4	0.31320245
95	MAP3K5	0.30609353
96	CAMK2A	0.29888732
97	CSNK2A1	0.29748652
98	RPS6KA6	0.29570466
99	PHKG2	0.27892645
100	PHKG1	0.27892645

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.26097617
2	Primary immunodeficiency_Homo sapiens_hsa05340	3.80445899
3	Caffeine metabolism_Homo sapiens_hsa00232	2.98936482
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.96927612
5	Proteasome_Homo sapiens_hsa03050	2.80026958
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.45848276
7	Allograft rejection_Homo sapiens_hsa05330	2.29226050
8	Parkinsons disease_Homo sapiens_hsa05012	2.25827534
9	Phototransduction_Homo sapiens_hsa04744	2.25589953
10	Graft-versus-host disease_Homo sapiens_hsa05332	2.19501418
11	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.18181975
12	Type I diabetes mellitus_Homo sapiens_hsa04940	2.06686492
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.98176193
14	RNA polymerase_Homo sapiens_hsa03020	1.95717921
15	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.92861312
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.84879520
17	Protein export_Homo sapiens_hsa03060	1.55858943
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.53510010
19	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.48487013
20	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.47230541
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.45318237
22	Ether lipid metabolism_Homo sapiens_hsa00565	1.44418160
23	Alzheimers disease_Homo sapiens_hsa05010	1.44252240
24	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.42575911
25	Asthma_Homo sapiens_hsa05310	1.39642988
26	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.37529652
27	Cardiac muscle contraction_Homo sapiens_hsa04260	1.36143941
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.33443307
29	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.31814153
30	Retinol metabolism_Homo sapiens_hsa00830	1.31477046
31	Antigen processing and presentation_Homo sapiens_hsa04612	1.30396975
32	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.29233440
33	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.26706058
34	Huntingtons disease_Homo sapiens_hsa05016	1.24569576
35	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.21545191
36	Olfactory transduction_Homo sapiens_hsa04740	1.19938314
37	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.18677966
38	Tryptophan metabolism_Homo sapiens_hsa00380	1.16672329
39	Butanoate metabolism_Homo sapiens_hsa00650	1.16409035
40	One carbon pool by folate_Homo sapiens_hsa00670	1.16316413
41	Homologous recombination_Homo sapiens_hsa03440	1.12695985
42	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.11231437
43	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.09779671
44	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.06470204
45	RNA degradation_Homo sapiens_hsa03018	1.06232404
46	Chemical carcinogenesis_Homo sapiens_hsa05204	1.03660441
47	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.00469028
48	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.00279540
49	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.00050165
50	Peroxisome_Homo sapiens_hsa04146	0.95644381
51	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.95495949
52	Propanoate metabolism_Homo sapiens_hsa00640	0.94077063
53	Pyrimidine metabolism_Homo sapiens_hsa00240	0.93973540
54	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.92891258
55	Rheumatoid arthritis_Homo sapiens_hsa05323	0.92452864
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.88433505
57	African trypanosomiasis_Homo sapiens_hsa05143	0.87638021
58	Fanconi anemia pathway_Homo sapiens_hsa03460	0.84026937
59	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.83473582
60	Purine metabolism_Homo sapiens_hsa00230	0.83430217
61	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.81800726
62	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.80482402
63	Taste transduction_Homo sapiens_hsa04742	0.77846699
64	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.74564799
65	Fat digestion and absorption_Homo sapiens_hsa04975	0.73288661
66	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.70746414
67	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.67813054
68	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.65774827
69	Nicotine addiction_Homo sapiens_hsa05033	0.64718798
70	Salivary secretion_Homo sapiens_hsa04970	0.62589427
71	Measles_Homo sapiens_hsa05162	0.62002309
72	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.58146197
73	Sulfur relay system_Homo sapiens_hsa04122	0.57584050
74	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.57155667
75	Metabolic pathways_Homo sapiens_hsa01100	0.55712857
76	Malaria_Homo sapiens_hsa05144	0.55472802
77	Basal transcription factors_Homo sapiens_hsa03022	0.53423130
78	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.44395586
79	Morphine addiction_Homo sapiens_hsa05032	0.43557821
80	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.42094053
81	Nucleotide excision repair_Homo sapiens_hsa03420	0.39724096
82	Collecting duct acid secretion_Homo sapiens_hsa04966	0.38461384
83	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.38408064
84	Regulation of autophagy_Homo sapiens_hsa04140	0.37703981
85	Folate biosynthesis_Homo sapiens_hsa00790	0.34785342
86	RNA transport_Homo sapiens_hsa03013	0.34520954
87	Base excision repair_Homo sapiens_hsa03410	0.32967486
88	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.32301351
89	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.31963618
90	Serotonergic synapse_Homo sapiens_hsa04726	0.31165270
91	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.29752282
92	Insulin secretion_Homo sapiens_hsa04911	0.25475058
93	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.24868273
94	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.24689726
95	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.24633505
96	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.24552377
97	Mineral absorption_Homo sapiens_hsa04978	0.23791747
98	Glycerolipid metabolism_Homo sapiens_hsa00561	0.23694724
99	Renin secretion_Homo sapiens_hsa04924	0.22450304
100	Pancreatic secretion_Homo sapiens_hsa04972	0.22426909

RPL5P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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