RPL5P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.05068200
2ribosomal small subunit assembly (GO:0000028)5.95903943
3translational termination (GO:0006415)5.85293224
4maturation of SSU-rRNA (GO:0030490)5.83442626
5ribosomal small subunit biogenesis (GO:0042274)5.26761270
6ATP synthesis coupled proton transport (GO:0015986)5.25494773
7energy coupled proton transport, down electrochemical gradient (GO:0015985)5.25494773
8behavioral response to nicotine (GO:0035095)5.20078439
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.15887126
10cotranslational protein targeting to membrane (GO:0006613)5.08773107
11protein targeting to ER (GO:0045047)5.04454363
12translational elongation (GO:0006414)4.96575024
13establishment of protein localization to endoplasmic reticulum (GO:0072599)4.82305642
14protein localization to endoplasmic reticulum (GO:0070972)4.79076434
15ribosomal large subunit biogenesis (GO:0042273)4.71657830
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.70194909
17viral life cycle (GO:0019058)4.45492594
18chaperone-mediated protein transport (GO:0072321)4.40380142
19DNA deamination (GO:0045006)4.36612392
20cellular protein complex disassembly (GO:0043624)4.30972570
21mitochondrial respiratory chain complex I assembly (GO:0032981)4.18259508
22NADH dehydrogenase complex assembly (GO:0010257)4.18259508
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.18259508
24nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.10551812
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.02154737
26translational initiation (GO:0006413)4.01433546
27protein complex biogenesis (GO:0070271)3.91897889
28protein neddylation (GO:0045116)3.91376623
29ribonucleoprotein complex biogenesis (GO:0022613)3.79887474
30water-soluble vitamin biosynthetic process (GO:0042364)3.78934559
31nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.78369721
32cellular component biogenesis (GO:0044085)3.73771817
33exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.72597788
34mitochondrial respiratory chain complex assembly (GO:0033108)3.64771950
35translation (GO:0006412)3.64002270
36positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.58031385
37regulation of hypersensitivity (GO:0002883)3.57533684
38protein complex disassembly (GO:0043241)3.56614567
39RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.50080848
40tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.50080848
41establishment of protein localization to mitochondrial membrane (GO:0090151)3.46711772
42respiratory electron transport chain (GO:0022904)3.43916605
43macromolecular complex disassembly (GO:0032984)3.43228242
44electron transport chain (GO:0022900)3.42906609
45protein targeting to membrane (GO:0006612)3.37545480
46transcription elongation from RNA polymerase III promoter (GO:0006385)3.27985353
47termination of RNA polymerase III transcription (GO:0006386)3.27985353
48respiratory chain complex IV assembly (GO:0008535)3.26403795
49ATP biosynthetic process (GO:0006754)3.24135824
50purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.23247351
51purine nucleoside triphosphate biosynthetic process (GO:0009145)3.22698200
52nuclear-transcribed mRNA catabolic process (GO:0000956)3.22324728
53regulation of cellular respiration (GO:0043457)3.21213297
54GTP biosynthetic process (GO:0006183)3.20433854
55indolalkylamine metabolic process (GO:0006586)3.10549713
56regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.09613576
57positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.09505006
58kynurenine metabolic process (GO:0070189)3.08272657
59mRNA catabolic process (GO:0006402)3.03627073
60nonmotile primary cilium assembly (GO:0035058)3.00881016
61ribosome biogenesis (GO:0042254)2.98514348
62hydrogen ion transmembrane transport (GO:1902600)2.91517267
63regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.90030744
64cell proliferation in forebrain (GO:0021846)2.86550159
65proton transport (GO:0015992)2.83983539
66regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.83155046
67ubiquinone biosynthetic process (GO:0006744)2.82816694
68epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.81612369
69piRNA metabolic process (GO:0034587)2.81372403
70hydrogen transport (GO:0006818)2.79679396
71synaptic transmission, cholinergic (GO:0007271)2.79315606
72cytochrome complex assembly (GO:0017004)2.78378419
73ribonucleoside triphosphate biosynthetic process (GO:0009201)2.76171706
74endoderm formation (GO:0001706)2.75634518
75rRNA processing (GO:0006364)2.74615618
76indole-containing compound catabolic process (GO:0042436)2.74300273
77indolalkylamine catabolic process (GO:0046218)2.74300273
78tryptophan catabolic process (GO:0006569)2.74300273
79protein polyglutamylation (GO:0018095)2.73956466
80rRNA metabolic process (GO:0016072)2.73492142
81RNA catabolic process (GO:0006401)2.72107015
82pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.69152346
83preassembly of GPI anchor in ER membrane (GO:0016254)2.65368199
84RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.65105715
85positive regulation of prostaglandin secretion (GO:0032308)2.63944291
86UTP biosynthetic process (GO:0006228)2.62497980
87fucose catabolic process (GO:0019317)2.62174300
88L-fucose metabolic process (GO:0042354)2.62174300
89L-fucose catabolic process (GO:0042355)2.62174300
90somite development (GO:0061053)2.61546233
91tRNA processing (GO:0008033)2.60674332
92aldehyde catabolic process (GO:0046185)2.60313707
93parturition (GO:0007567)2.58256596
94tryptophan metabolic process (GO:0006568)2.57272691
95maturation of 5.8S rRNA (GO:0000460)2.56506696
96ubiquinone metabolic process (GO:0006743)2.52299746
97UTP metabolic process (GO:0046051)2.50616437
98pseudouridine synthesis (GO:0001522)2.47165428
99protein peptidyl-prolyl isomerization (GO:0000413)2.46486144
100GPI anchor metabolic process (GO:0006505)2.39991811

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.92691114
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.58041299
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.57990026
4EZH2_22144423_ChIP-Seq_EOC_Human3.24650835
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.87545752
6ZNF274_21170338_ChIP-Seq_K562_Hela2.85359974
7VDR_22108803_ChIP-Seq_LS180_Human2.80507719
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.76029076
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.71637882
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.37007919
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.26964813
12VDR_23849224_ChIP-Seq_CD4+_Human2.03610313
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.97433996
14FLI1_27457419_Chip-Seq_LIVER_Mouse1.89702738
15MYC_18940864_ChIP-ChIP_HL60_Human1.89119761
16EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.87256469
17MYC_18555785_ChIP-Seq_MESCs_Mouse1.85676127
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84953936
19IGF1R_20145208_ChIP-Seq_DFB_Human1.83521646
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.77474616
21GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.69829701
22ELK1_19687146_ChIP-ChIP_HELA_Human1.69340709
23EWS_26573619_Chip-Seq_HEK293_Human1.67464545
24FUS_26573619_Chip-Seq_HEK293_Human1.64489889
25FOXP3_21729870_ChIP-Seq_TREG_Human1.57167877
26TP53_22573176_ChIP-Seq_HFKS_Human1.57138597
27TTF2_22483619_ChIP-Seq_HELA_Human1.55282930
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.54549222
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53910887
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49531947
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49521425
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49482430
33GBX2_23144817_ChIP-Seq_PC3_Human1.48536280
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48464344
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47916661
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.44414679
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43061777
38BP1_19119308_ChIP-ChIP_Hs578T_Human1.40533835
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.40117125
40ETV2_25802403_ChIP-Seq_MESCs_Mouse1.39588941
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38945166
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.38790858
43TAF15_26573619_Chip-Seq_HEK293_Human1.36801483
44P300_19829295_ChIP-Seq_ESCs_Human1.36722026
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34804084
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32672086
47FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32070811
48FOXA1_25329375_ChIP-Seq_VCAP_Human1.32070811
49CBP_20019798_ChIP-Seq_JUKART_Human1.26164790
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26164790
51ER_23166858_ChIP-Seq_MCF-7_Human1.25859097
52AR_20517297_ChIP-Seq_VCAP_Human1.25394709
53CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.23318352
54NCOR_22424771_ChIP-Seq_293T_Human1.22831034
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19219558
56GATA3_21878914_ChIP-Seq_MCF-7_Human1.18344879
57RNF2_27304074_Chip-Seq_NSC_Mouse1.18338573
58AUTS2_25519132_ChIP-Seq_293T-REX_Human1.18198932
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17781788
60MYC_18358816_ChIP-ChIP_MESCs_Mouse1.14391971
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14033354
62GABP_19822575_ChIP-Seq_HepG2_Human1.13880071
63TAF2_19829295_ChIP-Seq_ESCs_Human1.13395434
64NANOG_19829295_ChIP-Seq_ESCs_Human1.13307847
65SOX2_19829295_ChIP-Seq_ESCs_Human1.13307847
66EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.10430394
67PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07861131
68NANOG_20526341_ChIP-Seq_ESCs_Human1.07613895
69MYC_19829295_ChIP-Seq_ESCs_Human1.04545596
70IRF1_19129219_ChIP-ChIP_H3396_Human1.04205337
71IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03171106
72ERA_21632823_ChIP-Seq_H3396_Human1.02879795
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02862925
74EZH2_27304074_Chip-Seq_ESCs_Mouse1.02228117
75FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01971304
76TDRD3_21172665_ChIP-Seq_MCF-7_Human1.01327059
77REST_21632747_ChIP-Seq_MESCs_Mouse1.00693491
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.99874922
79POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99695089
80HOXB7_26014856_ChIP-Seq_BT474_Human0.99034617
81JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98595258
82FOXH1_21741376_ChIP-Seq_EPCs_Human0.98403528
83GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98050993
84ERG_20517297_ChIP-Seq_VCAP_Human0.97590833
85FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97471534
86RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95793005
87KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95506050
88FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93593805
89HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.93079097
90ELK1_22589737_ChIP-Seq_MCF10A_Human0.92789296
91SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92729216
92GATA3_26560356_Chip-Seq_TH2_Human0.91797749
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91520027
94TP63_19390658_ChIP-ChIP_HaCaT_Human0.91424935
95SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91420435
96NFE2_27457419_Chip-Seq_LIVER_Mouse0.91118326
97POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89762509
98EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.88786432
99EZH2_27294783_Chip-Seq_ESCs_Mouse0.87236708
100TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87075632

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.57340543
2MP0009379_abnormal_foot_pigmentation4.32338226
3MP0003787_abnormal_imprinting3.18178987
4MP0008877_abnormal_DNA_methylation2.88289612
5MP0002837_dystrophic_cardiac_calcinosis2.66192584
6MP0002653_abnormal_ependyma_morphology2.54891593
7MP0002102_abnormal_ear_morphology2.41068868
8MP0008789_abnormal_olfactory_epithelium2.24000455
9MP0004142_abnormal_muscle_tone2.12669080
10MP0005646_abnormal_pituitary_gland2.02221381
11MP0001986_abnormal_taste_sensitivity2.00587152
12MP0008872_abnormal_physiological_respon1.91711469
13MP0002163_abnormal_gland_morphology1.90449864
14MP0003122_maternal_imprinting1.89220972
15MP0001968_abnormal_touch/_nociception1.86995720
16MP0004145_abnormal_muscle_electrophysio1.82335688
17MP0002736_abnormal_nociception_after1.77652150
18MP0004885_abnormal_endolymph1.77170192
19MP0001835_abnormal_antigen_presentation1.64263630
20MP0001293_anophthalmia1.64045629
21MP0001348_abnormal_lacrimal_gland1.61312729
22MP0006276_abnormal_autonomic_nervous1.56046784
23MP0003878_abnormal_ear_physiology1.55829964
24MP0005377_hearing/vestibular/ear_phenot1.55829964
25MP0005551_abnormal_eye_electrophysiolog1.55568815
26MP0005394_taste/olfaction_phenotype1.53951265
27MP0005499_abnormal_olfactory_system1.53951265
28MP0002272_abnormal_nervous_system1.47151422
29MP0008775_abnormal_heart_ventricle1.41828295
30MP0002138_abnormal_hepatobiliary_system1.41379623
31MP0003646_muscle_fatigue1.39628730
32MP0005671_abnormal_response_to1.37429648
33MP0004147_increased_porphyrin_level1.36658281
34MP0002876_abnormal_thyroid_physiology1.34520639
35MP0006072_abnormal_retinal_apoptosis1.33376376
36MP0005645_abnormal_hypothalamus_physiol1.32193211
37MP0003121_genomic_imprinting1.30507998
38MP0005423_abnormal_somatic_nervous1.27098187
39MP0000049_abnormal_middle_ear1.24694263
40MP0005084_abnormal_gallbladder_morpholo1.21109215
41MP0008875_abnormal_xenobiotic_pharmacok1.20092826
42MP0004742_abnormal_vestibular_system1.19947200
43MP0005389_reproductive_system_phenotype1.19422222
44MP0003880_abnormal_central_pattern1.18802398
45MP0009745_abnormal_behavioral_response1.18427456
46MP0002733_abnormal_thermal_nociception1.17364639
47MP0002160_abnormal_reproductive_system1.15758594
48MP0001529_abnormal_vocalization1.15059572
49MP0005379_endocrine/exocrine_gland_phen1.14455010
50MP0002234_abnormal_pharynx_morphology1.12932901
51MP0001905_abnormal_dopamine_level1.11355749
52MP0002095_abnormal_skin_pigmentation1.10928396
53MP0002148_abnormal_hypersensitivity_rea1.10215214
54MP0001485_abnormal_pinna_reflex1.09389023
55MP0002938_white_spotting1.08665960
56MP0003567_abnormal_fetal_cardiomyocyte1.05453197
57MP0001873_stomach_inflammation1.04487829
58MP0003806_abnormal_nucleotide_metabolis1.04022071
59MP0001970_abnormal_pain_threshold1.04006344
60MP0003186_abnormal_redox_activity1.03808684
61MP0000631_abnormal_neuroendocrine_gland1.02889572
62MP0002638_abnormal_pupillary_reflex1.02645525
63MP0001440_abnormal_grooming_behavior1.02316043
64MP0003195_calcinosis1.01278925
65MP0006054_spinal_hemorrhage0.98606669
66MP0003011_delayed_dark_adaptation0.97280513
67MP0001800_abnormal_humoral_immune0.95354610
68MP0002557_abnormal_social/conspecific_i0.93772630
69MP0001984_abnormal_olfaction0.93013942
70MP0001919_abnormal_reproductive_system0.91721210
71MP0002277_abnormal_respiratory_mucosa0.91511304
72MP0009764_decreased_sensitivity_to0.90682304
73MP0000685_abnormal_immune_system0.89591379
74MP0001501_abnormal_sleep_pattern0.89582478
75MP0003718_maternal_effect0.87436089
76MP0000372_irregular_coat_pigmentation0.86299296
77MP0003786_premature_aging0.86256612
78MP0004133_heterotaxia0.85932411
79MP0009046_muscle_twitch0.84796583
80MP0000026_abnormal_inner_ear0.84675224
81MP0009785_altered_susceptibility_to0.83866030
82MP0005195_abnormal_posterior_eye0.82775605
83MP0006036_abnormal_mitochondrial_physio0.82764160
84MP0001764_abnormal_homeostasis0.82608415
85MP0001963_abnormal_hearing_physiology0.80409788
86MP0002735_abnormal_chemical_nociception0.80132952
87MP0000230_abnormal_systemic_arterial0.79203677
88MP0002572_abnormal_emotion/affect_behav0.77850584
89MP0005253_abnormal_eye_physiology0.77412361
90MP0000778_abnormal_nervous_system0.76427503
91MP0000569_abnormal_digit_pigmentation0.74164765
92MP0001486_abnormal_startle_reflex0.73789250
93MP0005636_abnormal_mineral_homeostasis0.73147608
94MP0009333_abnormal_splenocyte_physiolog0.72975848
95MP0003879_abnormal_hair_cell0.71914038
96MP0005332_abnormal_amino_acid0.70818444
97MP0002752_abnormal_somatic_nervous0.70708002
98MP0003315_abnormal_perineum_morphology0.70281056
99MP0001502_abnormal_circadian_rhythm0.68463810
100MP0001765_abnormal_ion_homeostasis0.67276270

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.27551419
2Abnormality of cells of the erythroid lineage (HP:0012130)3.96806063
3Reticulocytopenia (HP:0001896)3.85342204
4Mitochondrial inheritance (HP:0001427)3.84796618
5Increased CSF lactate (HP:0002490)3.71412433
6Abnormality of midbrain morphology (HP:0002418)3.69065364
7Molar tooth sign on MRI (HP:0002419)3.69065364
8Abnormal mitochondria in muscle tissue (HP:0008316)3.65243748
9Acute encephalopathy (HP:0006846)3.57703476
10Progressive macrocephaly (HP:0004481)3.48478684
113-Methylglutaconic aciduria (HP:0003535)3.47972734
12Abnormal number of erythroid precursors (HP:0012131)3.47566002
13Pancreatic cysts (HP:0001737)3.42286034
14Chronic hepatic failure (HP:0100626)3.41343297
15Pancreatic fibrosis (HP:0100732)3.29474720
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.25492278
17Absent/shortened dynein arms (HP:0200106)3.25492278
18Hepatocellular necrosis (HP:0001404)3.18349867
19Macrocytic anemia (HP:0001972)3.17189639
20Lipid accumulation in hepatocytes (HP:0006561)3.13136301
21Increased hepatocellular lipid droplets (HP:0006565)3.13107452
22Nephronophthisis (HP:0000090)3.12326517
23True hermaphroditism (HP:0010459)2.83382574
24Hepatic necrosis (HP:0002605)2.82171394
25Elevated erythrocyte sedimentation rate (HP:0003565)2.72686023
26Cerebral edema (HP:0002181)2.70738807
27Optic disc pallor (HP:0000543)2.66496541
28Increased serum lactate (HP:0002151)2.64893664
29Type 2 muscle fiber atrophy (HP:0003554)2.63240571
30Stomatitis (HP:0010280)2.62665909
31Congenital stationary night blindness (HP:0007642)2.62605039
32Absent rod-and cone-mediated responses on ERG (HP:0007688)2.54338352
33Abnormality of the renal medulla (HP:0100957)2.52548250
34Sclerocornea (HP:0000647)2.49019956
35Methylmalonic acidemia (HP:0002912)2.47397758
36Medial flaring of the eyebrow (HP:0010747)2.44627852
37Type II lissencephaly (HP:0007260)2.43398644
38Abolished electroretinogram (ERG) (HP:0000550)2.42884055
39Pallor (HP:0000980)2.41894427
40Abnormal rod and cone electroretinograms (HP:0008323)2.41627241
41Abnormal ciliary motility (HP:0012262)2.41157948
42Abnormal respiratory epithelium morphology (HP:0012253)2.40234145
43Abnormal respiratory motile cilium morphology (HP:0005938)2.40234145
44Colon cancer (HP:0003003)2.38413935
45Septo-optic dysplasia (HP:0100842)2.37953754
46IgG deficiency (HP:0004315)2.35104207
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.34758168
48Abnormality of alanine metabolism (HP:0010916)2.34758168
49Hyperalaninemia (HP:0003348)2.34758168
50Attenuation of retinal blood vessels (HP:0007843)2.29723874
51Renal Fanconi syndrome (HP:0001994)2.27943881
52Lactic acidosis (HP:0003128)2.25100620
53Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.25007950
54Pendular nystagmus (HP:0012043)2.16821112
55Muscle fiber atrophy (HP:0100295)2.16618974
56Abnormal respiratory motile cilium physiology (HP:0012261)2.16323559
57Increased intramyocellular lipid droplets (HP:0012240)2.14499637
58Rib fusion (HP:0000902)2.09447532
59Absent thumb (HP:0009777)2.03413048
60Cystic liver disease (HP:0006706)2.03382363
61Methylmalonic aciduria (HP:0012120)2.03339054
62Decreased electroretinogram (ERG) amplitude (HP:0000654)2.02177767
63Lethargy (HP:0001254)2.01227054
64Anencephaly (HP:0002323)2.01054374
65Optic nerve hypoplasia (HP:0000609)2.00589368
66Exertional dyspnea (HP:0002875)2.00029715
67Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.99936665
68Aplasia/Hypoplasia of the spleen (HP:0010451)1.98082187
69Congenital, generalized hypertrichosis (HP:0004540)1.95651439
70Abnormal hemoglobin (HP:0011902)1.95635590
71Adrenal hypoplasia (HP:0000835)1.94065601
72Anophthalmia (HP:0000528)1.92386776
73Leukodystrophy (HP:0002415)1.91614244
74Abnormality of the renal cortex (HP:0011035)1.90473272
75Cerebellar dysplasia (HP:0007033)1.90389249
76Increased muscle lipid content (HP:0009058)1.88441127
77Aplasia/Hypoplasia of the sacrum (HP:0008517)1.88376196
78Asplenia (HP:0001746)1.86999160
79Hyperglycinemia (HP:0002154)1.86945142
80Abnormal drinking behavior (HP:0030082)1.85298029
81Polydipsia (HP:0001959)1.85298029
82Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.85184909
83Abnormality of the phalanges of the 5th finger (HP:0004213)1.84260776
84Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.82646165
85Stenosis of the external auditory canal (HP:0000402)1.82621470
86Thyroid-stimulating hormone excess (HP:0002925)1.81535144
87Respiratory failure (HP:0002878)1.80236125
88Inability to walk (HP:0002540)1.80022828
89Male pseudohermaphroditism (HP:0000037)1.79174133
90Congenital hepatic fibrosis (HP:0002612)1.78458950
91Decreased central vision (HP:0007663)1.76611864
92Growth hormone deficiency (HP:0000824)1.76476103
93Depressed nasal ridge (HP:0000457)1.73829974
94Abnormality of urine glucose concentration (HP:0011016)1.73563983
95Glycosuria (HP:0003076)1.73563983
96Abnormality of the labia minora (HP:0012880)1.73417220
97Dyskinesia (HP:0100660)1.73213004
98Hypomagnesemia (HP:0002917)1.73179303
99Increased corneal curvature (HP:0100692)1.71821369
100Keratoconus (HP:0000563)1.71821369

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK3.85931449
2MAP4K23.34059383
3TLK13.01219841
4TXK2.98871576
5ZAK2.97240435
6NUAK12.83366432
7WNK42.66805745
8ADRBK22.55616433
9GRK12.37901960
10TAOK32.01463337
11FRK2.00905552
12BCKDK1.94981984
13STK161.93723038
14DYRK21.93182756
15CDK191.85633360
16PINK11.84479135
17WNK31.69498987
18TIE11.65439820
19TEC1.62657674
20CAMKK11.32017487
21STK391.28936880
22OXSR11.25134369
23MAP4K11.22302896
24ITK1.16296739
25PRKCQ1.10665076
26IKBKB1.09406211
27MAPK131.08746508
28KIT1.04904677
29RPS6KA51.03605341
30INSRR1.03099034
31CSNK1G20.99021655
32PIK3CA0.97555659
33VRK20.91762357
34PRKCG0.90622049
35LRRK20.90402496
36MKNK10.88991300
37VRK10.87093999
38MAP2K60.84862461
39SYK0.83904568
40EIF2AK30.83801427
41MKNK20.83305701
42DAPK20.81522683
43PLK40.81076725
44BTK0.80861707
45EPHB20.80418063
46ADRBK10.78630950
47CAMKK20.77649807
48SIK20.74069054
49PLK30.73836784
50MAP3K130.73615962
51PIK3CG0.73250456
52NME20.72964120
53MAP3K40.71329411
54MAP2K20.70028236
55FES0.68777257
56BMPR1B0.68760972
57EPHA40.68248805
58CSNK1G30.65912093
59MAP2K70.63836679
60NEK10.63133288
61NME10.61053067
62RPS6KA40.60338890
63GRK60.60112742
64PHKG10.59680279
65PHKG20.59680279
66OBSCN0.58501022
67IKBKE0.56998110
68LYN0.56118147
69PDK20.56024270
70TGFBR10.55103762
71CSNK2A20.54495594
72AURKB0.53703506
73NTRK20.53243687
74PRKCE0.52116470
75CAMK10.51909884
76LCK0.51851056
77PRKACA0.51600816
78CHUK0.51591640
79EIF2AK20.51416512
80DYRK30.50154875
81SRPK10.50124699
82ERBB30.49675085
83MAP3K140.49198971
84PLK10.48298546
85TRIM280.47495100
86NEK20.46978842
87MST40.46836596
88CSNK1G10.45453850
89PRKCD0.45130471
90PRKCA0.44903248
91ATR0.44547560
92CSNK2A10.43641387
93STK110.42431080
94ACVR1B0.40336318
95CSNK1A10.40284455
96MINK10.39838330
97RPS6KA60.37878153
98BUB10.37234988
99CSNK1A1L0.35565018
100PLK20.35483233

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.83096430
2Asthma_Homo sapiens_hsa053104.10482139
3Oxidative phosphorylation_Homo sapiens_hsa001903.48096849
4Parkinsons disease_Homo sapiens_hsa050122.85402641
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.52716011
6Allograft rejection_Homo sapiens_hsa053302.50579605
7RNA polymerase_Homo sapiens_hsa030202.46433251
8Autoimmune thyroid disease_Homo sapiens_hsa053202.43642722
9Protein export_Homo sapiens_hsa030602.43317302
10Proteasome_Homo sapiens_hsa030502.28226860
11Type I diabetes mellitus_Homo sapiens_hsa049402.02668602
12Graft-versus-host disease_Homo sapiens_hsa053321.96644649
13Huntingtons disease_Homo sapiens_hsa050161.88823535
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.87755067
15Homologous recombination_Homo sapiens_hsa034401.78052426
16Alzheimers disease_Homo sapiens_hsa050101.77369996
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.73613436
18Cardiac muscle contraction_Homo sapiens_hsa042601.70039828
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67356430
20RNA degradation_Homo sapiens_hsa030181.63253754
21Linoleic acid metabolism_Homo sapiens_hsa005911.58723384
22One carbon pool by folate_Homo sapiens_hsa006701.53639256
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48292418
24Phototransduction_Homo sapiens_hsa047441.44349894
25Tryptophan metabolism_Homo sapiens_hsa003801.32893353
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.29771207
27Basal transcription factors_Homo sapiens_hsa030221.26827416
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26531432
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25944244
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24171637
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20720465
32Primary immunodeficiency_Homo sapiens_hsa053401.16064340
33Butanoate metabolism_Homo sapiens_hsa006501.14677390
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14461314
35Nitrogen metabolism_Homo sapiens_hsa009101.14361185
36Rheumatoid arthritis_Homo sapiens_hsa053231.10567057
37Propanoate metabolism_Homo sapiens_hsa006401.05602396
38Pyrimidine metabolism_Homo sapiens_hsa002401.00271540
39Cysteine and methionine metabolism_Homo sapiens_hsa002700.99602244
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99076904
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98108590
42Nucleotide excision repair_Homo sapiens_hsa034200.98089372
43Nicotine addiction_Homo sapiens_hsa050330.94189404
44Regulation of autophagy_Homo sapiens_hsa041400.91249496
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89661155
46Antigen processing and presentation_Homo sapiens_hsa046120.89312069
47Arachidonic acid metabolism_Homo sapiens_hsa005900.87946814
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87922252
49Mismatch repair_Homo sapiens_hsa034300.87213984
50Fanconi anemia pathway_Homo sapiens_hsa034600.85416883
51Caffeine metabolism_Homo sapiens_hsa002320.81855361
52Purine metabolism_Homo sapiens_hsa002300.81715501
53Peroxisome_Homo sapiens_hsa041460.77283042
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75909240
55Steroid biosynthesis_Homo sapiens_hsa001000.73425744
56Chemical carcinogenesis_Homo sapiens_hsa052040.69903317
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69054765
58Sulfur relay system_Homo sapiens_hsa041220.68969533
59Staphylococcus aureus infection_Homo sapiens_hsa051500.67304239
60Base excision repair_Homo sapiens_hsa034100.66012479
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63955769
62Selenocompound metabolism_Homo sapiens_hsa004500.63351197
63Sulfur metabolism_Homo sapiens_hsa009200.62170065
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61841871
65Metabolic pathways_Homo sapiens_hsa011000.61612993
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61580466
67Fat digestion and absorption_Homo sapiens_hsa049750.59583363
68RNA transport_Homo sapiens_hsa030130.59310167
69Hematopoietic cell lineage_Homo sapiens_hsa046400.58463757
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57504195
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.57384809
72Ether lipid metabolism_Homo sapiens_hsa005650.57346033
73Spliceosome_Homo sapiens_hsa030400.56612852
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56547317
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56425910
76Olfactory transduction_Homo sapiens_hsa047400.56113695
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.55941099
78Collecting duct acid secretion_Homo sapiens_hsa049660.52987401
79Systemic lupus erythematosus_Homo sapiens_hsa053220.52610030
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50762727
81beta-Alanine metabolism_Homo sapiens_hsa004100.49403555
82Fatty acid degradation_Homo sapiens_hsa000710.48812857
83Fatty acid elongation_Homo sapiens_hsa000620.48259612
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47906225
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47759763
86Retinol metabolism_Homo sapiens_hsa008300.47139534
87Morphine addiction_Homo sapiens_hsa050320.46109998
88Viral myocarditis_Homo sapiens_hsa054160.45460107
89Taste transduction_Homo sapiens_hsa047420.44233704
90Glycerolipid metabolism_Homo sapiens_hsa005610.41407089
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39016677
92DNA replication_Homo sapiens_hsa030300.35839971
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34829505
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.34159703
95Fatty acid metabolism_Homo sapiens_hsa012120.33668393
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.32301432
97Serotonergic synapse_Homo sapiens_hsa047260.28428906
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.27580048
99Insulin secretion_Homo sapiens_hsa049110.27229722
100Glutathione metabolism_Homo sapiens_hsa004800.26357455

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