ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	6.55860738
2	protein neddylation (GO:0045116)	6.40030613
3	translational termination (GO:0006415)	6.31674362
4	ATP synthesis coupled proton transport (GO:0015986)	6.18845191
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.18845191
6	ribosomal small subunit assembly (GO:0000028)	5.98702078
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.75129938
8	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.70388504
9	cotranslational protein targeting to membrane (GO:0006613)	5.67515690
10	protein targeting to ER (GO:0045047)	5.61988848
11	chaperone-mediated protein transport (GO:0072321)	5.51722675
12	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.41483528
13	protein localization to endoplasmic reticulum (GO:0070972)	5.40009060
14	DNA deamination (GO:0045006)	5.26595740
15	translational elongation (GO:0006414)	5.23936721
16	ribosomal large subunit biogenesis (GO:0042273)	5.00524472
17	viral life cycle (GO:0019058)	4.80822644
18	cellular protein complex disassembly (GO:0043624)	4.67768577
19	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.58669524
20	water-soluble vitamin biosynthetic process (GO:0042364)	4.54527609
21	regulation of cilium movement (GO:0003352)	4.46341016
22	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.45061068
23	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.45061068
24	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.40741089
25	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.38472732
26	ribosomal small subunit biogenesis (GO:0042274)	4.26610021
27	translational initiation (GO:0006413)	4.26448957
28	respiratory electron transport chain (GO:0022904)	4.19356327
29	electron transport chain (GO:0022900)	4.17083899
30	parturition (GO:0007567)	4.15624181
31	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.06989092
32	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.06989092
33	NADH dehydrogenase complex assembly (GO:0010257)	4.06989092
34	protein complex biogenesis (GO:0070271)	3.97785327
35	ribonucleoprotein complex disassembly (GO:0032988)	3.94989620
36	macromolecular complex disassembly (GO:0032984)	3.91072509
37	protein complex disassembly (GO:0043241)	3.90773493
38	mitochondrial respiratory chain complex assembly (GO:0033108)	3.82688400
39	nonmotile primary cilium assembly (GO:0035058)	3.81231892
40	translation (GO:0006412)	3.75475301
41	maturation of SSU-rRNA (GO:0030490)	3.74649447
42	protein targeting to membrane (GO:0006612)	3.73420476
43	organelle disassembly (GO:1903008)	3.71365463
44	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.61782964
45	kynurenine metabolic process (GO:0070189)	3.61647865
46	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.61495545
47	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.34701198
48	tryptophan catabolic process (GO:0006569)	3.33299611
49	indole-containing compound catabolic process (GO:0042436)	3.33299611
50	indolalkylamine catabolic process (GO:0046218)	3.33299611
51	ATP biosynthetic process (GO:0006754)	3.27401104
52	hypothalamus development (GO:0021854)	3.23596921
53	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.21969886
54	mRNA catabolic process (GO:0006402)	3.19463150
55	cellular component biogenesis (GO:0044085)	3.07019121
56	hydrogen ion transmembrane transport (GO:1902600)	3.04563670
57	ubiquinone biosynthetic process (GO:0006744)	3.03613523
58	regulation of microtubule-based movement (GO:0060632)	3.01984694
59	spliceosomal complex assembly (GO:0000245)	2.96870199
60	behavioral response to nicotine (GO:0035095)	2.95188543
61	RNA catabolic process (GO:0006401)	2.94397275
62	resolution of meiotic recombination intermediates (GO:0000712)	2.92252013
63	respiratory chain complex IV assembly (GO:0008535)	2.87749677
64	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.87366350
65	brain morphogenesis (GO:0048854)	2.86435813
66	negative regulation of appetite (GO:0032099)	2.85807597
67	negative regulation of response to food (GO:0032096)	2.85807597
68	hydrogen transport (GO:0006818)	2.85275607
69	ribonucleoprotein complex biogenesis (GO:0022613)	2.85235105
70	proton transport (GO:0015992)	2.83880306
71	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.83328979
72	regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)	2.82441241
73	striatum development (GO:0021756)	2.81738263
74	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.81045113
75	regulation of cellular respiration (GO:0043457)	2.78507355
76	cell proliferation in forebrain (GO:0021846)	2.75259322
77	vitamin biosynthetic process (GO:0009110)	2.74165164
78	phenylpropanoid metabolic process (GO:0009698)	2.72649897
79	protein K6-linked ubiquitination (GO:0085020)	2.69633200
80	kinetochore assembly (GO:0051382)	2.67338078
81	mitochondrial calcium ion transport (GO:0006851)	2.66292906
82	ubiquinone metabolic process (GO:0006743)	2.65106812
83	tRNA processing (GO:0008033)	2.62586905
84	chromatin remodeling at centromere (GO:0031055)	2.59285823
85	daunorubicin metabolic process (GO:0044597)	2.57044569
86	polyketide metabolic process (GO:0030638)	2.57044569
87	doxorubicin metabolic process (GO:0044598)	2.57044569
88	cytochrome complex assembly (GO:0017004)	2.56705748
89	substrate-independent telencephalic tangential migration (GO:0021826)	2.56361492
90	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.56361492
91	somite development (GO:0061053)	2.53961384
92	artery smooth muscle contraction (GO:0014824)	2.53936690
93	viral protein processing (GO:0019082)	2.53649791
94	protein targeting (GO:0006605)	2.51301481
95	kinetochore organization (GO:0051383)	2.51190560
96	tryptophan metabolic process (GO:0006568)	2.50543519
97	autophagic vacuole fusion (GO:0000046)	2.50314069
98	pyrimidine nucleotide catabolic process (GO:0006244)	2.46127633
99	mitochondrial calcium ion homeostasis (GO:0051560)	2.45829013
100	retinal cone cell development (GO:0046549)	2.45342438

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.04411476
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.25020543
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.08991992
4	VDR_22108803_ChIP-Seq_LS180_Human	3.30472420
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.01906398
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.69343174
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.63232919
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.54962055
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.35665633
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.25632164
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.22408981
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.20331621
13	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.17618208
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.10785481
15	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.08826637
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.04527554
17	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.98679801
18	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.92615470
19	EWS_26573619_Chip-Seq_HEK293_Human	1.88892858
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.88296131
21	IRF1_19129219_ChIP-ChIP_H3396_Human	1.84888464
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.80879113
23	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.71060585
24	ELK1_19687146_ChIP-ChIP_HELA_Human	1.68835661
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.67141499
26	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.62325141
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.61285658
28	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.61245887
29	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.53966702
30	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.52892550
31	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.52892550
32	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.51980385
33	FUS_26573619_Chip-Seq_HEK293_Human	1.47930120
34	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.47726809
35	IGF1R_20145208_ChIP-Seq_DFB_Human	1.45848640
36	TTF2_22483619_ChIP-Seq_HELA_Human	1.45836502
37	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.42884518
38	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.40287715
39	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.37343900
40	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.36489758
41	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.34558647
42	CBP_20019798_ChIP-Seq_JUKART_Human	1.28498129
43	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.28498129
44	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.27492451
45	P300_19829295_ChIP-Seq_ESCs_Human	1.27012006
46	TP53_22573176_ChIP-Seq_HFKS_Human	1.26000439
47	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.25821786
48	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.25253034
49	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.24275801
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23783654
51	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23783654
52	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.21593873
53	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.21421722
54	NCOR_22424771_ChIP-Seq_293T_Human	1.18761201
55	AR_20517297_ChIP-Seq_VCAP_Human	1.17625796
56	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.15853533
57	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.15377939
58	HTT_18923047_ChIP-ChIP_STHdh_Human	1.15315949
59	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.15063728
60	TAF2_19829295_ChIP-Seq_ESCs_Human	1.14397820
61	ER_23166858_ChIP-Seq_MCF-7_Human	1.12560788
62	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.12544684
63	GBX2_23144817_ChIP-Seq_PC3_Human	1.08394826
64	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.08014689
65	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.07961944
66	RNF2_27304074_Chip-Seq_NSC_Mouse	1.06960552
67	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.06800832
68	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.06287958
69	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.06247152
70	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.05046623
71	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.03167059
72	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.01010456
73	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.99926532
74	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.97927366
75	NANOG_20526341_ChIP-Seq_ESCs_Human	0.97090272
76	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.96234694
77	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.96222100
78	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.96098320
79	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.96053358
80	REST_21632747_ChIP-Seq_MESCs_Mouse	0.94084860
81	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.92535036
82	CDX2_22108803_ChIP-Seq_LS180_Human	0.89424427
83	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.88179426
84	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.87715559
85	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.87550241
86	SOX2_21211035_ChIP-Seq_LN229_Human	0.87443533
87	TCF4_22108803_ChIP-Seq_LS180_Human	0.87201392
88	P53_22387025_ChIP-Seq_ESCs_Mouse	0.86900988
89	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.86789532
90	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.86632527
91	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.85860477
92	TAF15_26573619_Chip-Seq_HEK293_Human	0.85806674
93	XRN2_22483619_ChIP-Seq_HELA_Human	0.85623308
94	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.85120290
95	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.84462322
96	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.83858839
97	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.83235186
98	AR_25329375_ChIP-Seq_VCAP_Human	0.82516958
99	GABP_19822575_ChIP-Seq_HepG2_Human	0.81612603
100	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.81316381

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	5.04781105
2	MP0009379_abnormal_foot_pigmentation	3.69436410
3	MP0003806_abnormal_nucleotide_metabolis	3.41861191
4	MP0003787_abnormal_imprinting	3.12050629
5	MP0003123_paternal_imprinting	2.96245603
6	MP0006072_abnormal_retinal_apoptosis	2.84361965
7	MP0003880_abnormal_central_pattern	2.47957782
8	MP0003195_calcinosis	2.38708268
9	MP0004145_abnormal_muscle_electrophysio	2.38032819
10	MP0004142_abnormal_muscle_tone	2.30533146
11	MP0002102_abnormal_ear_morphology	2.09186437
12	MP0001529_abnormal_vocalization	2.05205219
13	MP0004885_abnormal_endolymph	1.93573288
14	MP0000631_abnormal_neuroendocrine_gland	1.93093430
15	MP0006276_abnormal_autonomic_nervous	1.92624898
16	MP0002163_abnormal_gland_morphology	1.92357470
17	MP0008877_abnormal_DNA_methylation	1.92168454
18	MP0005084_abnormal_gallbladder_morpholo	1.85567680
19	MP0001293_anophthalmia	1.83520042
20	MP0003122_maternal_imprinting	1.81496005
21	MP0008789_abnormal_olfactory_epithelium	1.81371941
22	MP0005670_abnormal_white_adipose	1.74823513
23	MP0002638_abnormal_pupillary_reflex	1.73110910
24	MP0001919_abnormal_reproductive_system	1.62979478
25	MP0001968_abnormal_touch/_nociception	1.53608433
26	MP0001905_abnormal_dopamine_level	1.53082739
27	MP0003121_genomic_imprinting	1.52470832
28	MP0003646_muscle_fatigue	1.49656415
29	MP0005551_abnormal_eye_electrophysiolog	1.47671186
30	MP0006036_abnormal_mitochondrial_physio	1.43340035
31	MP0001188_hyperpigmentation	1.42397994
32	MP0005389_reproductive_system_phenotype	1.41498384
33	MP0002736_abnormal_nociception_after	1.40173522
34	MP0005646_abnormal_pituitary_gland	1.36043185
35	MP0002938_white_spotting	1.35781021
36	MP0001440_abnormal_grooming_behavior	1.35153342
37	MP0003724_increased_susceptibility_to	1.34513400
38	MP0002138_abnormal_hepatobiliary_system	1.33614244
39	MP0005499_abnormal_olfactory_system	1.28947224
40	MP0005394_taste/olfaction_phenotype	1.28947224
41	MP0001986_abnormal_taste_sensitivity	1.27249075
42	MP0002876_abnormal_thyroid_physiology	1.26349051
43	MP0002160_abnormal_reproductive_system	1.23067790
44	MP0005075_abnormal_melanosome_morpholog	1.23011333
45	MP0001970_abnormal_pain_threshold	1.21866538
46	MP0001835_abnormal_antigen_presentation	1.19075160
47	MP0003718_maternal_effect	1.19000875
48	MP0002272_abnormal_nervous_system	1.15630578
49	MP0001485_abnormal_pinna_reflex	1.14969479
50	MP0005360_urolithiasis	1.14425805
51	MP0002733_abnormal_thermal_nociception	1.13536541
52	MP0005379_endocrine/exocrine_gland_phen	1.13512373
53	MP0003186_abnormal_redox_activity	1.12401641
54	MP0003183_abnormal_peptide_metabolism	1.12107941
55	MP0005423_abnormal_somatic_nervous	1.11878363
56	MP0003011_delayed_dark_adaptation	1.11687073
57	MP0005253_abnormal_eye_physiology	1.09585933
58	MP0005408_hypopigmentation	1.09024379
59	MP0008875_abnormal_xenobiotic_pharmacok	1.06897730
60	MP0004147_increased_porphyrin_level	1.06521152
61	MP0008775_abnormal_heart_ventricle	1.06364329
62	MP0006035_abnormal_mitochondrial_morpho	1.01477631
63	MP0002572_abnormal_emotion/affect_behav	0.99844657
64	MP0005195_abnormal_posterior_eye	0.99776810
65	MP0008872_abnormal_physiological_respon	0.98011801
66	MP0004019_abnormal_vitamin_homeostasis	0.97459381
67	MP0009764_decreased_sensitivity_to	0.97042668
68	MP0005636_abnormal_mineral_homeostasis	0.96388332
69	MP0002234_abnormal_pharynx_morphology	0.95916550
70	MP0002557_abnormal_social/conspecific_i	0.94703685
71	MP0009046_muscle_twitch	0.94261083
72	MP0002928_abnormal_bile_duct	0.93596726
73	MP0005645_abnormal_hypothalamus_physiol	0.92460851
74	MP0002184_abnormal_innervation	0.90713348
75	MP0001286_abnormal_eye_development	0.90424053
76	MP0002735_abnormal_chemical_nociception	0.89812751
77	MP0010386_abnormal_urinary_bladder	0.89499027
78	MP0002653_abnormal_ependyma_morphology	0.86161511
79	MP0009745_abnormal_behavioral_response	0.85537988
80	MP0000778_abnormal_nervous_system	0.84989589
81	MP0008058_abnormal_DNA_repair	0.84987506
82	MP0001765_abnormal_ion_homeostasis	0.84958054
83	MP0000427_abnormal_hair_cycle	0.84619736
84	MP0005671_abnormal_response_to	0.84062634
85	MP0000955_abnormal_spinal_cord	0.83878749
86	MP0002837_dystrophic_cardiac_calcinosis	0.83825281
87	MP0001984_abnormal_olfaction	0.83384231
88	MP0009780_abnormal_chondrocyte_physiolo	0.82816401
89	MP0000230_abnormal_systemic_arterial	0.80837259
90	MP0000049_abnormal_middle_ear	0.80443126
91	MP0002752_abnormal_somatic_nervous	0.80312961
92	MP0001756_abnormal_urination	0.73136621
93	MP0003693_abnormal_embryo_hatching	0.72224692
94	MP0001486_abnormal_startle_reflex	0.67455321
95	MP0003878_abnormal_ear_physiology	0.67280571
96	MP0005377_hearing/vestibular/ear_phenot	0.67280571
97	MP0003879_abnormal_hair_cell	0.65800638
98	MP0005332_abnormal_amino_acid	0.65010595
99	MP0002734_abnormal_mechanical_nocicepti	0.63161442
100	MP0001324_abnormal_eye_pigmentation	0.63092740

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.59969272
2	Mitochondrial inheritance (HP:0001427)	4.21088662
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.19149512
4	Acute encephalopathy (HP:0006846)	3.96761181
5	Abnormality of cells of the erythroid lineage (HP:0012130)	3.91969640
6	Methylmalonic acidemia (HP:0002912)	3.90323451
7	Increased hepatocellular lipid droplets (HP:0006565)	3.89883478
8	Macrocytic anemia (HP:0001972)	3.85519568
9	Lipid accumulation in hepatocytes (HP:0006561)	3.83623103
10	Increased CSF lactate (HP:0002490)	3.78399847
11	Progressive macrocephaly (HP:0004481)	3.69915854
12	3-Methylglutaconic aciduria (HP:0003535)	3.48999936
13	Congenital stationary night blindness (HP:0007642)	3.47271602
14	Stenosis of the external auditory canal (HP:0000402)	3.28224857
15	Congenital, generalized hypertrichosis (HP:0004540)	3.21446240
16	Renal Fanconi syndrome (HP:0001994)	3.16950380
17	Exertional dyspnea (HP:0002875)	3.13209274
18	Increased intramyocellular lipid droplets (HP:0012240)	3.08457782
19	Adrenal hypoplasia (HP:0000835)	3.07922847
20	Medial flaring of the eyebrow (HP:0010747)	3.06457925
21	Molar tooth sign on MRI (HP:0002419)	2.98520821
22	Abnormality of midbrain morphology (HP:0002418)	2.98520821
23	Cerebral edema (HP:0002181)	2.97781699
24	Hepatocellular necrosis (HP:0001404)	2.92509165
25	Septo-optic dysplasia (HP:0100842)	2.89179387
26	Hyperglycinemia (HP:0002154)	2.81187804
27	Reticulocytopenia (HP:0001896)	2.78151977
28	Gait imbalance (HP:0002141)	2.73277148
29	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.72942989
30	Pallor (HP:0000980)	2.72489322
31	Methylmalonic aciduria (HP:0012120)	2.70546627
32	Increased muscle lipid content (HP:0009058)	2.69309202
33	Nephronophthisis (HP:0000090)	2.69169151
34	Abnormal number of erythroid precursors (HP:0012131)	2.66950342
35	Abnormal rod and cone electroretinograms (HP:0008323)	2.64521875
36	Abnormality of renal resorption (HP:0011038)	2.64432818
37	Congenital primary aphakia (HP:0007707)	2.63548684
38	Hepatic necrosis (HP:0002605)	2.61080273
39	Increased serum lactate (HP:0002151)	2.60991927
40	Abnormality of urine glucose concentration (HP:0011016)	2.55761735
41	Glycosuria (HP:0003076)	2.55761735
42	Lactic acidosis (HP:0003128)	2.54892915
43	Increased serum pyruvate (HP:0003542)	2.53702219
44	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.51224328
45	Abnormality of alanine metabolism (HP:0010916)	2.51224328
46	Hyperalaninemia (HP:0003348)	2.51224328
47	Pancreatic cysts (HP:0001737)	2.46051424
48	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.43573086
49	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.43573086
50	Nephrogenic diabetes insipidus (HP:0009806)	2.43490141
51	Abolished electroretinogram (ERG) (HP:0000550)	2.40574562
52	Myokymia (HP:0002411)	2.36225239
53	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.29076954
54	Respiratory difficulties (HP:0002880)	2.28151772
55	Rib fusion (HP:0000902)	2.23439016
56	Abnormality of serum amino acid levels (HP:0003112)	2.22364178
57	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.21876756
58	Pancreatic fibrosis (HP:0100732)	2.20964812
59	Growth hormone deficiency (HP:0000824)	2.18783449
60	Abnormality of vitamin B metabolism (HP:0004340)	2.14300454
61	Lethargy (HP:0001254)	2.13846951
62	Myotonia (HP:0002486)	2.13036260
63	Genital tract atresia (HP:0001827)	2.12927590
64	Vaginal atresia (HP:0000148)	2.09882214
65	Abnormality of the renal medulla (HP:0100957)	2.07868789
66	Leukodystrophy (HP:0002415)	2.06628235
67	Optic disc pallor (HP:0000543)	2.05199905
68	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.96591783
69	Poor coordination (HP:0002370)	1.96259485
70	Optic nerve hypoplasia (HP:0000609)	1.94339481
71	Exercise intolerance (HP:0003546)	1.94332804
72	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.94121140
73	Hyperphosphaturia (HP:0003109)	1.88344730
74	Sclerocornea (HP:0000647)	1.86594146
75	Abnormal pancreas size (HP:0012094)	1.85787703
76	Abnormality of DNA repair (HP:0003254)	1.84690679
77	Absent thumb (HP:0009777)	1.83406082
78	Panhypogammaglobulinemia (HP:0003139)	1.82515143
79	Polyuria (HP:0000103)	1.79331117
80	Aplastic anemia (HP:0001915)	1.79284459
81	Limb dystonia (HP:0002451)	1.79026455
82	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.76438423
83	Dicarboxylic aciduria (HP:0003215)	1.76322650
84	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.76322650
85	Porencephaly (HP:0002132)	1.76083978
86	Abnormality of the prostate (HP:0008775)	1.73701103
87	Cerebellar dysplasia (HP:0007033)	1.72534155
88	Respiratory failure (HP:0002878)	1.72424298
89	Median cleft lip (HP:0000161)	1.72296231
90	Pachygyria (HP:0001302)	1.69753826
91	Abnormality of glycolysis (HP:0004366)	1.69486782
92	Woolly hair (HP:0002224)	1.67812715
93	Pendular nystagmus (HP:0012043)	1.67390248
94	Hypomagnesemia (HP:0002917)	1.67336770
95	Pancytopenia (HP:0001876)	1.66122660
96	Small hand (HP:0200055)	1.65398134
97	True hermaphroditism (HP:0010459)	1.64248931
98	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.63442746
99	Disproportionate short-trunk short stature (HP:0003521)	1.62873633
100	Decreased central vision (HP:0007663)	1.62321201

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K12	3.26528910
2	TRIM28	3.00209722
3	STK16	2.76938164
4	TLK1	2.64951371
5	ADRBK2	2.49547002
6	NUAK1	2.46112414
7	PIK3CA	2.29674617
8	BCKDK	2.28904143
9	DYRK2	2.24057488
10	CDC7	2.21920462
11	GRK1	2.19335058
12	PDK2	1.98368936
13	NEK1	1.95255489
14	TAOK3	1.77440387
15	CDK8	1.73683005
16	CAMKK2	1.69335327
17	ZAK	1.65861869
18	WNK3	1.61392807
19	BMPR1B	1.61034564
20	PINK1	1.60195335
21	CDK19	1.55977338
22	TEC	1.43921884
23	MYLK	1.43248358
24	PLK4	1.42508345
25	CASK	1.36619409
26	WNK4	1.30499486
27	PASK	1.27053041
28	TXK	1.23334482
29	ITK	1.20547982
30	PLK2	1.18574860
31	MKNK1	1.14316773
32	CSNK1G2	1.11848500
33	MAP3K9	1.11074964
34	EIF2AK3	1.07861784
35	DYRK1B	1.07616186
36	MST4	1.06483404
37	FRK	1.01556226
38	RPS6KA5	1.00574574
39	EPHA4	0.99966343
40	CSNK1G3	0.98902104
41	BTK	0.98029008
42	IKBKB	0.92977863
43	KIT	0.92355764
44	INSRR	0.88114471
45	VRK1	0.83984088
46	ERBB2	0.83811417
47	LYN	0.82876844
48	PRKCG	0.82613030
49	AURKB	0.81224606
50	MAPKAPK5	0.80422074
51	ADRBK1	0.75595243
52	BRAF	0.75307712
53	IKBKE	0.72625550
54	PRKCQ	0.72077701
55	OXSR1	0.71852025
56	LIMK1	0.70740225
57	CAMKK1	0.70559462
58	MATK	0.70255855
59	GRK7	0.68588224
60	ARAF	0.67405834
61	SYK	0.67359524
62	AKT3	0.67048612
63	MAPK13	0.67026770
64	PRKCE	0.65875429
65	CSNK1G1	0.65069934
66	FLT3	0.63983437
67	CSF1R	0.61243000
68	CSNK1A1L	0.60869959
69	PLK3	0.60644074
70	ILK	0.60559588
71	NTRK3	0.59947906
72	NEK2	0.59464030
73	IRAK4	0.58906057
74	CHEK2	0.58858930
75	MINK1	0.57510202
76	VRK2	0.57474704
77	NTRK2	0.56536130
78	TNIK	0.56314232
79	CSNK2A2	0.55189017
80	CDK9	0.54867404
81	LCK	0.54682841
82	PIK3CG	0.54366352
83	MKNK2	0.54254798
84	OBSCN	0.51649635
85	EPHB2	0.51057982
86	CDK3	0.50460370
87	ABL2	0.49432457
88	PRKACA	0.49285786
89	EIF2AK2	0.48418662
90	PHKG1	0.48033544
91	PHKG2	0.48033544
92	DAPK3	0.47581670
93	IGF1R	0.46633912
94	GRK5	0.46600634
95	MAP4K2	0.45415806
96	PRKCD	0.44008106
97	CAMK2A	0.43360368
98	RPS6KA4	0.43237410
99	CAMK1D	0.42587007
100	CSNK1A1	0.42101256

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.62591205
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.20461107
3	Protein export_Homo sapiens_hsa03060	3.98245573
4	Parkinsons disease_Homo sapiens_hsa05012	3.63417064
5	Asthma_Homo sapiens_hsa05310	3.33407292
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.64826880
7	Cardiac muscle contraction_Homo sapiens_hsa04260	2.40980104
8	Huntingtons disease_Homo sapiens_hsa05016	2.29663417
9	Alzheimers disease_Homo sapiens_hsa05010	2.26657492
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.07850522
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.96115749
12	Proteasome_Homo sapiens_hsa03050	1.95708975
13	Allograft rejection_Homo sapiens_hsa05330	1.89026225
14	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.87968451
15	Graft-versus-host disease_Homo sapiens_hsa05332	1.81701393
16	Type I diabetes mellitus_Homo sapiens_hsa04940	1.77791380
17	Homologous recombination_Homo sapiens_hsa03440	1.69441457
18	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.58008611
19	Propanoate metabolism_Homo sapiens_hsa00640	1.55205211
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.45284168
21	RNA polymerase_Homo sapiens_hsa03020	1.40942030
22	RNA degradation_Homo sapiens_hsa03018	1.34365285
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.33500507
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.29704971
25	Basal transcription factors_Homo sapiens_hsa03022	1.29648252
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.24922308
27	Phototransduction_Homo sapiens_hsa04744	1.24679951
28	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.24268717
29	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.12366634
30	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.10872931
31	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.08946144
32	Nucleotide excision repair_Homo sapiens_hsa03420	1.04653660
33	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.03448827
34	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.98273777
35	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.98238959
36	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.95425019
37	Rheumatoid arthritis_Homo sapiens_hsa05323	0.94775191
38	Steroid biosynthesis_Homo sapiens_hsa00100	0.94761292
39	Sulfur metabolism_Homo sapiens_hsa00920	0.91500734
40	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.89995061
41	Pyruvate metabolism_Homo sapiens_hsa00620	0.88310000
42	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.87932548
43	Tryptophan metabolism_Homo sapiens_hsa00380	0.87879689
44	Regulation of autophagy_Homo sapiens_hsa04140	0.87498481
45	Folate biosynthesis_Homo sapiens_hsa00790	0.87448026
46	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.85209309
47	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.80798619
48	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.79205897
49	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.79007063
50	Sulfur relay system_Homo sapiens_hsa04122	0.78868056
51	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.75285186
52	Mismatch repair_Homo sapiens_hsa03430	0.74622734
53	Antigen processing and presentation_Homo sapiens_hsa04612	0.72188325
54	One carbon pool by folate_Homo sapiens_hsa00670	0.71821416
55	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.69479596
56	Nicotine addiction_Homo sapiens_hsa05033	0.66863222
57	Spliceosome_Homo sapiens_hsa03040	0.66482720
58	Chemical carcinogenesis_Homo sapiens_hsa05204	0.66346281
59	Fat digestion and absorption_Homo sapiens_hsa04975	0.66135913
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.65853380
61	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.65765360
62	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.65377758
63	RNA transport_Homo sapiens_hsa03013	0.65362717
64	Ether lipid metabolism_Homo sapiens_hsa00565	0.64492187
65	Retinol metabolism_Homo sapiens_hsa00830	0.63297622
66	Butanoate metabolism_Homo sapiens_hsa00650	0.62627186
67	Collecting duct acid secretion_Homo sapiens_hsa04966	0.62620477
68	Nitrogen metabolism_Homo sapiens_hsa00910	0.62187118
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.61826193
70	Pyrimidine metabolism_Homo sapiens_hsa00240	0.59500601
71	Metabolic pathways_Homo sapiens_hsa01100	0.57426026
72	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.53433840
73	Olfactory transduction_Homo sapiens_hsa04740	0.52520978
74	Morphine addiction_Homo sapiens_hsa05032	0.51386670
75	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.47913040
76	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.47508062
77	Serotonergic synapse_Homo sapiens_hsa04726	0.47487355
78	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.47367561
79	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.46999745
80	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.46746818
81	Purine metabolism_Homo sapiens_hsa00230	0.46516311
82	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.45362597
83	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.43262711
84	Caffeine metabolism_Homo sapiens_hsa00232	0.41232115
85	Viral myocarditis_Homo sapiens_hsa05416	0.40257874
86	Peroxisome_Homo sapiens_hsa04146	0.40214247
87	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.38373094
88	Leishmaniasis_Homo sapiens_hsa05140	0.37221055
89	Mineral absorption_Homo sapiens_hsa04978	0.34639416
90	Taste transduction_Homo sapiens_hsa04742	0.32563342
91	DNA replication_Homo sapiens_hsa03030	0.32354735
92	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.31820808
93	Insulin secretion_Homo sapiens_hsa04911	0.30756278
94	Primary immunodeficiency_Homo sapiens_hsa05340	0.28815145
95	Salivary secretion_Homo sapiens_hsa04970	0.28602147
96	Glycerolipid metabolism_Homo sapiens_hsa00561	0.26743852
97	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.26540635
98	Base excision repair_Homo sapiens_hsa03410	0.26462261
99	Circadian entrainment_Homo sapiens_hsa04713	0.24587543
100	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.22224538

RPL5P7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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