RPL5P8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ATP synthesis coupled proton transport (GO:0015986)5.89246672
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.89246672
3chaperone-mediated protein transport (GO:0072321)5.76975628
4DNA deamination (GO:0045006)5.43807863
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.29669175
6maturation of SSU-rRNA (GO:0030490)5.03752211
7ribosomal small subunit assembly (GO:0000028)4.91396035
8ribosomal large subunit biogenesis (GO:0042273)4.77113791
9viral transcription (GO:0019083)4.64323558
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.59022463
11exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.57973391
12tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.57178524
13RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.57178524
14nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.54513056
15translational termination (GO:0006415)4.53258336
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.37187354
17establishment of protein localization to mitochondrial membrane (GO:0090151)4.32771160
18protein complex biogenesis (GO:0070271)4.31495945
19cotranslational protein targeting to membrane (GO:0006613)4.29624787
20protein neddylation (GO:0045116)4.29401813
21ribosomal small subunit biogenesis (GO:0042274)4.28888048
22protein targeting to ER (GO:0045047)4.26738533
23water-soluble vitamin biosynthetic process (GO:0042364)4.24063731
24respiratory electron transport chain (GO:0022904)4.11648584
25translational elongation (GO:0006414)4.08267233
26electron transport chain (GO:0022900)4.08266268
27establishment of protein localization to endoplasmic reticulum (GO:0072599)4.07162145
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.05107580
29mitochondrial respiratory chain complex I assembly (GO:0032981)4.05107580
30NADH dehydrogenase complex assembly (GO:0010257)4.05107580
31protein localization to endoplasmic reticulum (GO:0070972)4.03085517
32mitochondrial respiratory chain complex assembly (GO:0033108)4.02073612
33GTP biosynthetic process (GO:0006183)3.82494723
34termination of RNA polymerase III transcription (GO:0006386)3.71763324
35transcription elongation from RNA polymerase III promoter (GO:0006385)3.71763324
36pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.67659829
37translation (GO:0006412)3.65994701
38purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.45506908
39purine nucleoside triphosphate biosynthetic process (GO:0009145)3.45177355
40proteasome assembly (GO:0043248)3.40665000
41translational initiation (GO:0006413)3.40517662
42respiratory chain complex IV assembly (GO:0008535)3.39953574
43viral life cycle (GO:0019058)3.38609790
44ATP biosynthetic process (GO:0006754)3.33826545
45cellular component biogenesis (GO:0044085)3.32878773
46rRNA modification (GO:0000154)3.32838818
47cellular protein complex disassembly (GO:0043624)3.30824568
48aldehyde catabolic process (GO:0046185)3.29132094
49cytochrome complex assembly (GO:0017004)3.26376622
50regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.25633663
51base-excision repair, AP site formation (GO:0006285)3.20037799
52nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.19986334
53UTP biosynthetic process (GO:0006228)3.18518406
54behavioral response to nicotine (GO:0035095)3.15961459
55RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.08158813
56regulation of cellular amino acid metabolic process (GO:0006521)3.06585454
57signal peptide processing (GO:0006465)3.05673862
58hydrogen ion transmembrane transport (GO:1902600)3.04436752
59preassembly of GPI anchor in ER membrane (GO:0016254)3.04016319
60protein polyglutamylation (GO:0018095)3.03941949
61rRNA processing (GO:0006364)3.02377831
62negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.00324414
63ribonucleoside triphosphate biosynthetic process (GO:0009201)2.99278412
64ribonucleoprotein complex biogenesis (GO:0022613)2.98472828
65rRNA metabolic process (GO:0016072)2.97587587
66DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.97528428
67maturation of 5.8S rRNA (GO:0000460)2.97142149
68pyrimidine nucleotide catabolic process (GO:0006244)2.96312839
69UTP metabolic process (GO:0046051)2.95741595
70tRNA processing (GO:0008033)2.95721642
71guanosine-containing compound biosynthetic process (GO:1901070)2.95029057
72protein deneddylation (GO:0000338)2.91909456
73GPI anchor metabolic process (GO:0006505)2.91762453
74signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.90514119
75signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.90514119
76signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.90514119
77positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.89533985
78proton transport (GO:0015992)2.87197614
79signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.85716946
80intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.85716946
81nuclear-transcribed mRNA catabolic process (GO:0000956)2.84355042
82positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.84352692
83protein targeting to mitochondrion (GO:0006626)2.83443280
84hydrogen transport (GO:0006818)2.82837780
85GPI anchor biosynthetic process (GO:0006506)2.82415415
86pseudouridine synthesis (GO:0001522)2.80418484
87protein targeting to membrane (GO:0006612)2.77908608
88signal transduction involved in DNA damage checkpoint (GO:0072422)2.74265310
89signal transduction involved in DNA integrity checkpoint (GO:0072401)2.74265310
90signal transduction involved in cell cycle checkpoint (GO:0072395)2.70872522
91cytidine metabolic process (GO:0046087)2.70372566
92cytidine catabolic process (GO:0006216)2.70372566
93cytidine deamination (GO:0009972)2.70372566
94negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.70120921
95negative regulation of ligase activity (GO:0051352)2.70120921
96intracellular protein transmembrane import (GO:0044743)2.69597528
97establishment of protein localization to mitochondrion (GO:0072655)2.68795734
98regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.67476835
99protein complex disassembly (GO:0043241)2.66537981
100mRNA catabolic process (GO:0006402)2.66177981

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.51564736
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.47534791
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.86675911
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.53560027
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.16652731
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.14801884
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.09056125
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.91986858
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.81694439
10VDR_23849224_ChIP-Seq_CD4+_Human2.66275700
11ZNF274_21170338_ChIP-Seq_K562_Hela2.59210994
12VDR_22108803_ChIP-Seq_LS180_Human2.58858164
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.55867351
14ELK1_19687146_ChIP-ChIP_HELA_Human2.39495664
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.35783853
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.25581126
17FOXP3_21729870_ChIP-Seq_TREG_Human2.16463585
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.11823421
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.10096778
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.01264133
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.00456009
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.98273177
23SRF_21415370_ChIP-Seq_HL-1_Mouse1.85707949
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77469593
25EWS_26573619_Chip-Seq_HEK293_Human1.75208107
26IGF1R_20145208_ChIP-Seq_DFB_Human1.74624349
27MYC_18940864_ChIP-ChIP_HL60_Human1.71315221
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.55446606
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.54569494
30TTF2_22483619_ChIP-Seq_HELA_Human1.53584127
31TP53_22573176_ChIP-Seq_HFKS_Human1.53508860
32FUS_26573619_Chip-Seq_HEK293_Human1.47087279
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43192408
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43049240
35E2F4_17652178_ChIP-ChIP_JURKAT_Human1.42691054
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41806868
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.41033818
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39748577
39POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36358980
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.36341821
41TAF15_26573619_Chip-Seq_HEK293_Human1.35929193
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35642409
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.33221338
44IRF1_19129219_ChIP-ChIP_H3396_Human1.32775271
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.32572917
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30889884
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.30889884
48GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28241525
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27968746
50GABP_19822575_ChIP-Seq_HepG2_Human1.26999967
51DCP1A_22483619_ChIP-Seq_HELA_Human1.26128955
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24490989
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.24382229
54MYC_19030024_ChIP-ChIP_MESCs_Mouse1.22918774
55AR_20517297_ChIP-Seq_VCAP_Human1.21756137
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21406548
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19109600
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18349615
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.18124640
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17528743
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15963098
62MYC_19079543_ChIP-ChIP_MESCs_Mouse1.15063520
63AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14642330
64EZH2_22144423_ChIP-Seq_EOC_Human1.14450571
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12848734
66P300_19829295_ChIP-Seq_ESCs_Human1.12557663
67E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12194164
68FOXH1_21741376_ChIP-Seq_EPCs_Human1.12113030
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10926491
70ER_23166858_ChIP-Seq_MCF-7_Human1.10795952
71SOX2_19829295_ChIP-Seq_ESCs_Human1.09664819
72NANOG_19829295_ChIP-Seq_ESCs_Human1.09664819
73BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09554676
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.09049794
75GATA3_26560356_Chip-Seq_TH2_Human1.08947265
76CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06287738
77IRF8_22096565_ChIP-ChIP_GC-B_Human1.05574211
78XRN2_22483619_ChIP-Seq_HELA_Human1.05561012
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04894655
80IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04512094
81GATA3_21878914_ChIP-Seq_MCF-7_Human1.03908421
82NCOR_22424771_ChIP-Seq_293T_Human1.02804589
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01131398
84POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99824164
85ELK1_22589737_ChIP-Seq_MCF10A_Human0.99471862
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96899769
87CBP_20019798_ChIP-Seq_JUKART_Human0.96899769
88NANOG_20526341_ChIP-Seq_ESCs_Human0.95265214
89HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93271383
90CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92729338
91ERG_20517297_ChIP-Seq_VCAP_Human0.92570073
92GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.92251144
93TAF2_19829295_ChIP-Seq_ESCs_Human0.90675954
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90518566
95RBPJ_21746931_ChIP-Seq_IB4_Human0.89863950
96GATA6_21074721_ChIP-Seq_CACO-2_Human0.89370201
97FOXA1_21572438_ChIP-Seq_LNCaP_Human0.88157738
98TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87606653
99EZH2_27294783_Chip-Seq_NPCs_Mouse0.87177698
100PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.86599366

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.85667700
2MP0006292_abnormal_olfactory_placode3.30951938
3MP0005671_abnormal_response_to3.08330850
4MP0001835_abnormal_antigen_presentation2.93317769
5MP0006072_abnormal_retinal_apoptosis2.75027761
6MP0008877_abnormal_DNA_methylation2.33636436
7MP0002837_dystrophic_cardiac_calcinosis2.32287737
8MP0004147_increased_porphyrin_level2.20451447
9MP0003195_calcinosis2.15635659
10MP0003646_muscle_fatigue2.12231843
11MP0002163_abnormal_gland_morphology2.05507276
12MP0002102_abnormal_ear_morphology1.99939379
13MP0008875_abnormal_xenobiotic_pharmacok1.91026200
14MP0008872_abnormal_physiological_respon1.90439624
15MP0002736_abnormal_nociception_after1.90369883
16MP0004145_abnormal_muscle_electrophysio1.90103722
17MP0003011_delayed_dark_adaptation1.89815314
18MP0005551_abnormal_eye_electrophysiolog1.87248790
19MP0005645_abnormal_hypothalamus_physiol1.84237085
20MP0008058_abnormal_DNA_repair1.75916756
21MP0003787_abnormal_imprinting1.73889979
22MP0001968_abnormal_touch/_nociception1.73456261
23MP0003786_premature_aging1.72076832
24MP0008789_abnormal_olfactory_epithelium1.69806548
25MP0001529_abnormal_vocalization1.67498458
26MP0005646_abnormal_pituitary_gland1.66530064
27MP0006036_abnormal_mitochondrial_physio1.64916704
28MP0003806_abnormal_nucleotide_metabolis1.63037709
29MP0004142_abnormal_muscle_tone1.61903263
30MP0002138_abnormal_hepatobiliary_system1.60832822
31MP0002638_abnormal_pupillary_reflex1.60729586
32MP0005379_endocrine/exocrine_gland_phen1.52143590
33MP0002876_abnormal_thyroid_physiology1.51856435
34MP0005084_abnormal_gallbladder_morpholo1.49205910
35MP0001986_abnormal_taste_sensitivity1.48329874
36MP0001873_stomach_inflammation1.38959391
37MP0003186_abnormal_redox_activity1.36297023
38MP0001905_abnormal_dopamine_level1.33952541
39MP0005389_reproductive_system_phenotype1.33838158
40MP0008995_early_reproductive_senescence1.33085250
41MP0004885_abnormal_endolymph1.29923583
42MP0005387_immune_system_phenotype1.27317354
43MP0001790_abnormal_immune_system1.27317354
44MP0005253_abnormal_eye_physiology1.26582983
45MP0001293_anophthalmia1.25887682
46MP0002160_abnormal_reproductive_system1.25490461
47MP0000372_irregular_coat_pigmentation1.24980653
48MP0002277_abnormal_respiratory_mucosa1.24066290
49MP0001485_abnormal_pinna_reflex1.23563645
50MP0009785_altered_susceptibility_to1.22209475
51MP0001800_abnormal_humoral_immune1.22131165
52MP0002148_abnormal_hypersensitivity_rea1.21397439
53MP0005075_abnormal_melanosome_morpholog1.20615028
54MP0000685_abnormal_immune_system1.19672744
55MP0001984_abnormal_olfaction1.19404372
56MP0002272_abnormal_nervous_system1.14211690
57MP0005499_abnormal_olfactory_system1.13348775
58MP0005394_taste/olfaction_phenotype1.13348775
59MP0003693_abnormal_embryo_hatching1.12863486
60MP0001919_abnormal_reproductive_system1.07556643
61MP0009745_abnormal_behavioral_response1.06553826
62MP0002234_abnormal_pharynx_morphology1.04745763
63MP0006035_abnormal_mitochondrial_morpho1.03846642
64MP0008775_abnormal_heart_ventricle1.02046045
65MP0009046_muscle_twitch1.01325224
66MP0009764_decreased_sensitivity_to1.00955710
67MP0009333_abnormal_splenocyte_physiolog0.98226301
68MP0003718_maternal_effect0.98225842
69MP0005636_abnormal_mineral_homeostasis0.93171174
70MP0004133_heterotaxia0.92074860
71MP0005332_abnormal_amino_acid0.90888466
72MP0004782_abnormal_surfactant_physiolog0.90338239
73MP0005000_abnormal_immune_tolerance0.90096985
74MP0005195_abnormal_posterior_eye0.85566764
75MP0001501_abnormal_sleep_pattern0.85251661
76MP0000631_abnormal_neuroendocrine_gland0.84194395
77MP0002095_abnormal_skin_pigmentation0.83169378
78MP0001970_abnormal_pain_threshold0.81631184
79MP0000049_abnormal_middle_ear0.81127598
80MP0002723_abnormal_immune_serum0.80221348
81MP0005410_abnormal_fertilization0.79712057
82MP0005377_hearing/vestibular/ear_phenot0.79491806
83MP0003878_abnormal_ear_physiology0.79491806
84MP0006276_abnormal_autonomic_nervous0.79057113
85MP0002693_abnormal_pancreas_physiology0.78671302
86MP0004215_abnormal_myocardial_fiber0.76783059
87MP0002735_abnormal_chemical_nociception0.76442376
88MP0003121_genomic_imprinting0.75356594
89MP0002938_white_spotting0.73031975
90MP0001765_abnormal_ion_homeostasis0.72287126
91MP0005085_abnormal_gallbladder_physiolo0.72202656
92MP0003880_abnormal_central_pattern0.71527323
93MP0002006_tumorigenesis0.71379019
94MP0002452_abnormal_antigen_presenting0.70200502
95MP0003283_abnormal_digestive_organ0.69502801
96MP0000230_abnormal_systemic_arterial0.69462303
97MP0002557_abnormal_social/conspecific_i0.67968194
98MP0002420_abnormal_adaptive_immunity0.66804160
99MP0001819_abnormal_immune_cell0.66013580
100MP0002210_abnormal_sex_determination0.65509599

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.96539312
2Mitochondrial inheritance (HP:0001427)4.43945642
3Abnormal mitochondria in muscle tissue (HP:0008316)4.31993035
4Acute encephalopathy (HP:0006846)4.29956943
5Progressive macrocephaly (HP:0004481)4.22448434
6Increased CSF lactate (HP:0002490)4.19654713
73-Methylglutaconic aciduria (HP:0003535)3.99538229
8Increased hepatocellular lipid droplets (HP:0006565)3.84402739
9Hepatocellular necrosis (HP:0001404)3.63977919
10Lipid accumulation in hepatocytes (HP:0006561)3.52552475
11Abnormality of midbrain morphology (HP:0002418)3.46137823
12Molar tooth sign on MRI (HP:0002419)3.46137823
13Hepatic necrosis (HP:0002605)3.33359258
14Cerebral edema (HP:0002181)3.21345966
15Renal Fanconi syndrome (HP:0001994)3.17372577
16Methylmalonic acidemia (HP:0002912)3.17277892
17Absent rod-and cone-mediated responses on ERG (HP:0007688)3.12105730
18Abnormal rod and cone electroretinograms (HP:0008323)2.85062212
19Macrocytic anemia (HP:0001972)2.84797081
20Increased serum lactate (HP:0002151)2.84251393
21Nephronophthisis (HP:0000090)2.77434243
22Congenital stationary night blindness (HP:0007642)2.76807734
23Reticulocytopenia (HP:0001896)2.75114711
24Abnormality of cells of the erythroid lineage (HP:0012130)2.74914738
25Optic disc pallor (HP:0000543)2.73388628
26Congenital, generalized hypertrichosis (HP:0004540)2.68471149
27Absent/shortened dynein arms (HP:0200106)2.67610002
28Dynein arm defect of respiratory motile cilia (HP:0012255)2.67610002
29Pancreatic cysts (HP:0001737)2.67272890
30Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.66793751
31Exertional dyspnea (HP:0002875)2.64711756
32Lactic acidosis (HP:0003128)2.63993694
33Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.60178933
34Abnormality of alanine metabolism (HP:0010916)2.60178933
35Hyperalaninemia (HP:0003348)2.60178933
36Abolished electroretinogram (ERG) (HP:0000550)2.59952497
37Increased intramyocellular lipid droplets (HP:0012240)2.59808830
38IgG deficiency (HP:0004315)2.59280257
39Medial flaring of the eyebrow (HP:0010747)2.56570974
40Pendular nystagmus (HP:0012043)2.54115498
41Methylmalonic aciduria (HP:0012120)2.49331097
42Abnormal respiratory motile cilium morphology (HP:0005938)2.43456704
43Abnormal respiratory epithelium morphology (HP:0012253)2.43456704
44Respiratory failure (HP:0002878)2.39854052
45Attenuation of retinal blood vessels (HP:0007843)2.39607657
46Pancreatic fibrosis (HP:0100732)2.39420329
47Stomatitis (HP:0010280)2.39121593
48Elevated erythrocyte sedimentation rate (HP:0003565)2.38887241
49Abnormal number of erythroid precursors (HP:0012131)2.34377383
50Hyperglycinemia (HP:0002154)2.29687932
51Hypoproteinemia (HP:0003075)2.28832098
52Decreased activity of mitochondrial respiratory chain (HP:0008972)2.27808294
53Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.27808294
54Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.26841249
55Abnormality of the renal medulla (HP:0100957)2.26038434
56Lethargy (HP:0001254)2.23202233
57Abnormality of renal resorption (HP:0011038)2.22148548
58Leukodystrophy (HP:0002415)2.20348666
59Decreased electroretinogram (ERG) amplitude (HP:0000654)2.17924518
60True hermaphroditism (HP:0010459)2.16973641
61Exercise intolerance (HP:0003546)2.07727646
62Decreased central vision (HP:0007663)2.07190331
63Increased muscle lipid content (HP:0009058)2.07085315
64Pallor (HP:0000980)2.06385122
65Respiratory difficulties (HP:0002880)2.05426599
66Testicular atrophy (HP:0000029)2.04750791
67Type 2 muscle fiber atrophy (HP:0003554)2.04172042
68Colon cancer (HP:0003003)2.03669056
69Abnormality of serum amino acid levels (HP:0003112)2.02696231
70Abnormality of the renal cortex (HP:0011035)1.98858386
71Type II lissencephaly (HP:0007260)1.97755803
72Aplasia/Hypoplasia of the spleen (HP:0010451)1.97400238
73Abnormality of vitamin B metabolism (HP:0004340)1.96182104
74Abnormality of urine glucose concentration (HP:0011016)1.95533870
75Glycosuria (HP:0003076)1.95533870
76Absent thumb (HP:0009777)1.95356998
77CNS demyelination (HP:0007305)1.93792514
78Asplenia (HP:0001746)1.93513865
79Severe combined immunodeficiency (HP:0004430)1.93032376
80Abnormal respiratory motile cilium physiology (HP:0012261)1.92111363
81Abnormal ciliary motility (HP:0012262)1.91308995
82Abnormality of the vitamin B12 metabolism (HP:0004341)1.90872139
83Constricted visual fields (HP:0001133)1.86498822
84Hypomagnesemia (HP:0002917)1.84747708
85Aplastic anemia (HP:0001915)1.84343102
86Abnormality of aspartate family amino acid metabolism (HP:0010899)1.83841833
87Polydipsia (HP:0001959)1.79914202
88Abnormal drinking behavior (HP:0030082)1.79914202
89Keratoconus (HP:0000563)1.79406312
90Increased corneal curvature (HP:0100692)1.79406312
91Thyroiditis (HP:0100646)1.78576243
92Cleft eyelid (HP:0000625)1.76843363
93Congenital primary aphakia (HP:0007707)1.76281543
94Dicarboxylic aciduria (HP:0003215)1.74254970
95Abnormality of dicarboxylic acid metabolism (HP:0010995)1.74254970
96Agitation (HP:0000713)1.74070530
97Hyperphosphaturia (HP:0003109)1.73907096
98Abnormality of B cell number (HP:0010975)1.72091980
99Renal cortical cysts (HP:0000803)1.71817524
100Gait imbalance (HP:0002141)1.71589084

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.33411647
2ZAK3.11406185
3TLK13.03767823
4FRK2.86264144
5TXK2.79890359
6EIF2AK32.40689062
7NUAK12.40276192
8ADRBK22.36007628
9GRK12.33069462
10STK162.29498703
11WNK31.88032247
12BMPR1B1.71897557
13TIE11.70815018
14NME21.69061056
15WNK41.68610794
16TRIM281.64381181
17TEC1.64220874
18PLK41.62754803
19VRK21.62239085
20BCKDK1.60759587
21MAP3K121.59310655
22MST41.53490634
23ACVR1B1.51060991
24TAOK31.38225615
25PINK11.35428789
26NEK11.25158585
27OXSR11.24213941
28EIF2AK11.22642781
29VRK11.20551581
30PASK1.19545782
31PLK31.18091526
32TSSK61.15804127
33KIT1.14215253
34NME11.14101802
35PDK21.13687983
36ITK1.12619793
37IKBKB1.10127899
38INSRR1.09499993
39MKNK21.08457934
40STK391.07075804
41SRPK11.07036794
42DYRK21.05419920
43MAP4K11.05253913
44BMPR21.04573184
45FES0.96105738
46MAP2K60.92496420
47PHKG10.91144246
48PHKG20.91144246
49BUB10.81108321
50CDK190.81028704
51CDC70.78800730
52MYLK0.78758651
53MAP3K40.78028007
54ADRBK10.77038988
55TGFBR10.74405025
56MKNK10.74116532
57CSNK1G30.73326516
58RPS6KA50.72919411
59ERBB30.71028304
60BTK0.70791545
61SYK0.68619606
62EIF2AK20.68250901
63PRKCG0.67884424
64DAPK20.64690451
65CSNK1G10.63993546
66PLK10.63972830
67GRK70.63208288
68CSNK1G20.63089933
69CSF1R0.62979805
70PLK20.62978072
71PIK3CA0.62867140
72CSNK2A20.61935656
73CDK80.61920867
74PRKCQ0.61346321
75CSNK2A10.60646580
76OBSCN0.60333997
77SCYL20.59508089
78IKBKE0.58887312
79ATR0.57847996
80KDR0.57635366
81CAMKK20.56957962
82MUSK0.55610874
83TNIK0.54732768
84LCK0.54325617
85LYN0.51621171
86PRKACA0.51456504
87TAF10.50846895
88PBK0.50452784
89PRKCE0.48999416
90FLT30.48279345
91MAPK130.47742670
92DAPK10.46778797
93AURKB0.46176781
94PRKCA0.44527407
95CSNK1A1L0.44365450
96CSNK1A10.43896950
97MAP2K20.43023970
98IGF1R0.42011384
99CAMK2D0.40252602
100CAMK2A0.36725928

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.25637649
2Oxidative phosphorylation_Homo sapiens_hsa001903.83427028
3Proteasome_Homo sapiens_hsa030503.75086714
4Asthma_Homo sapiens_hsa053103.19282742
5Parkinsons disease_Homo sapiens_hsa050123.13413936
6Protein export_Homo sapiens_hsa030603.06086583
7Allograft rejection_Homo sapiens_hsa053302.61794844
8Autoimmune thyroid disease_Homo sapiens_hsa053202.43972348
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.43238521
10RNA polymerase_Homo sapiens_hsa030202.41950325
11Graft-versus-host disease_Homo sapiens_hsa053322.19715327
12Type I diabetes mellitus_Homo sapiens_hsa049402.17347758
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.11816404
14Alzheimers disease_Homo sapiens_hsa050102.01586873
15Huntingtons disease_Homo sapiens_hsa050162.00343776
16Homologous recombination_Homo sapiens_hsa034401.82820925
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.80128166
18RNA degradation_Homo sapiens_hsa030181.79618179
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.77335541
20Cardiac muscle contraction_Homo sapiens_hsa042601.65292417
21One carbon pool by folate_Homo sapiens_hsa006701.52450294
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.51802910
23Phototransduction_Homo sapiens_hsa047441.40954080
24Basal transcription factors_Homo sapiens_hsa030221.40784782
25Mismatch repair_Homo sapiens_hsa034301.39180996
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.35759336
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.33443790
28Rheumatoid arthritis_Homo sapiens_hsa053231.25328352
29Pyrimidine metabolism_Homo sapiens_hsa002401.24483163
30Linoleic acid metabolism_Homo sapiens_hsa005911.22769029
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21823182
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21337236
33Primary immunodeficiency_Homo sapiens_hsa053401.19238378
34Fanconi anemia pathway_Homo sapiens_hsa034601.15795854
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14505811
36Propanoate metabolism_Homo sapiens_hsa006401.14139906
37DNA replication_Homo sapiens_hsa030301.08562482
38RNA transport_Homo sapiens_hsa030131.08168045
39Antigen processing and presentation_Homo sapiens_hsa046121.07467741
40Sulfur metabolism_Homo sapiens_hsa009201.05157590
41Tryptophan metabolism_Homo sapiens_hsa003801.04417652
42Nucleotide excision repair_Homo sapiens_hsa034201.03492128
43Purine metabolism_Homo sapiens_hsa002301.00484861
44Nitrogen metabolism_Homo sapiens_hsa009100.98006685
45Spliceosome_Homo sapiens_hsa030400.97724849
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89654702
47Collecting duct acid secretion_Homo sapiens_hsa049660.89476515
48Regulation of autophagy_Homo sapiens_hsa041400.85579303
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.82595936
50Peroxisome_Homo sapiens_hsa041460.79688946
51Butanoate metabolism_Homo sapiens_hsa006500.75729541
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75641175
53Base excision repair_Homo sapiens_hsa034100.74257072
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.73492223
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71318274
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71294598
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70593535
58Caffeine metabolism_Homo sapiens_hsa002320.70355872
59Arachidonic acid metabolism_Homo sapiens_hsa005900.69282872
60Metabolic pathways_Homo sapiens_hsa011000.66632868
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66103443
62Olfactory transduction_Homo sapiens_hsa047400.63122806
63Selenocompound metabolism_Homo sapiens_hsa004500.62825383
64Systemic lupus erythematosus_Homo sapiens_hsa053220.62591107
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60356734
66Ether lipid metabolism_Homo sapiens_hsa005650.59612819
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.59233440
68Hematopoietic cell lineage_Homo sapiens_hsa046400.59071290
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59065920
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58996510
71Chemical carcinogenesis_Homo sapiens_hsa052040.58262206
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55335004
73Retinol metabolism_Homo sapiens_hsa008300.54059974
74Fatty acid elongation_Homo sapiens_hsa000620.53964234
75Viral myocarditis_Homo sapiens_hsa054160.52970347
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.47296492
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47232818
78Pyruvate metabolism_Homo sapiens_hsa006200.47042001
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46774588
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45629795
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.44730464
82Non-homologous end-joining_Homo sapiens_hsa034500.44607936
83Vitamin B6 metabolism_Homo sapiens_hsa007500.44231434
84Staphylococcus aureus infection_Homo sapiens_hsa051500.42338585
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.42179924
86Fat digestion and absorption_Homo sapiens_hsa049750.40880991
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38320136
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36220047
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33276862
90Fatty acid degradation_Homo sapiens_hsa000710.31967274
91Nicotine addiction_Homo sapiens_hsa050330.26025069
92Folate biosynthesis_Homo sapiens_hsa007900.24537501
93beta-Alanine metabolism_Homo sapiens_hsa004100.21867118
94Epstein-Barr virus infection_Homo sapiens_hsa051690.21547392
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.20328956
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.18142339
97Glutathione metabolism_Homo sapiens_hsa004800.17178070
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.15935482
99Sulfur relay system_Homo sapiens_hsa041220.15389704
100Serotonergic synapse_Homo sapiens_hsa047260.15040798

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