ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.72590997
2	viral transcription (GO:0019083)	6.13044262
3	translational termination (GO:0006415)	5.90889145
4	maturation of SSU-rRNA (GO:0030490)	5.59733688
5	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.19462716
6	translational elongation (GO:0006414)	5.18296762
7	cotranslational protein targeting to membrane (GO:0006613)	5.11782837
8	protein targeting to ER (GO:0045047)	5.06591745
9	ribosomal large subunit biogenesis (GO:0042273)	5.04306450
10	ribosomal small subunit biogenesis (GO:0042274)	4.99684164
11	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.84907199
12	protein localization to endoplasmic reticulum (GO:0070972)	4.76992002
13	protein neddylation (GO:0045116)	4.73434248
14	DNA deamination (GO:0045006)	4.72447177
15	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.52381935
16	ATP synthesis coupled proton transport (GO:0015986)	4.52381935
17	viral life cycle (GO:0019058)	4.37302196
18	cellular protein complex disassembly (GO:0043624)	4.35362282
19	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.24094744
20	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.12710102
21	translational initiation (GO:0006413)	3.97743463
22	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.89354970
23	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.89354970
24	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.88053777
25	protein complex biogenesis (GO:0070271)	3.80149852
26	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.76390997
27	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.76390997
28	NADH dehydrogenase complex assembly (GO:0010257)	3.76390997
29	behavioral response to nicotine (GO:0035095)	3.66808590
30	translation (GO:0006412)	3.58580638
31	protein complex disassembly (GO:0043241)	3.53071355
32	ribonucleoprotein complex biogenesis (GO:0022613)	3.48220182
33	chaperone-mediated protein transport (GO:0072321)	3.47688947
34	respiratory electron transport chain (GO:0022904)	3.47003042
35	electron transport chain (GO:0022900)	3.45955795
36	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.43800778
37	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.42839602
38	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.40492928
39	macromolecular complex disassembly (GO:0032984)	3.40433950
40	cellular component biogenesis (GO:0044085)	3.40058377
41	mitochondrial respiratory chain complex assembly (GO:0033108)	3.39436935
42	water-soluble vitamin biosynthetic process (GO:0042364)	3.35733620
43	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.35186011
44	GTP biosynthetic process (GO:0006183)	3.27921011
45	kynurenine metabolic process (GO:0070189)	3.25400745
46	protein targeting to membrane (GO:0006612)	3.22672317
47	respiratory chain complex IV assembly (GO:0008535)	3.15264828
48	response to pheromone (GO:0019236)	3.14774222
49	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.08391055
50	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.06636252
51	termination of RNA polymerase III transcription (GO:0006386)	3.06636252
52	indolalkylamine catabolic process (GO:0046218)	2.98671557
53	tryptophan catabolic process (GO:0006569)	2.98671557
54	indole-containing compound catabolic process (GO:0042436)	2.98671557
55	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.92480828
56	cell proliferation in forebrain (GO:0021846)	2.91435536
57	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.91164168
58	mRNA catabolic process (GO:0006402)	2.90731370
59	cytidine metabolic process (GO:0046087)	2.89743500
60	cytidine catabolic process (GO:0006216)	2.89743500
61	cytidine deamination (GO:0009972)	2.89743500
62	axoneme assembly (GO:0035082)	2.83436999
63	cytochrome complex assembly (GO:0017004)	2.82478233
64	ATP biosynthetic process (GO:0006754)	2.81289191
65	forebrain morphogenesis (GO:0048853)	2.79347909
66	platelet dense granule organization (GO:0060155)	2.75933757
67	rRNA processing (GO:0006364)	2.71927423
68	UTP biosynthetic process (GO:0006228)	2.71496581
69	rRNA metabolic process (GO:0016072)	2.70750080
70	rRNA catabolic process (GO:0016075)	2.69570994
71	sequestering of actin monomers (GO:0042989)	2.67954880
72	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.66287359
73	hydrogen ion transmembrane transport (GO:1902600)	2.65985904
74	UTP metabolic process (GO:0046051)	2.65037443
75	RNA catabolic process (GO:0006401)	2.63954351
76	rRNA modification (GO:0000154)	2.62857831
77	proton transport (GO:0015992)	2.56524522
78	indolalkylamine metabolic process (GO:0006586)	2.56440273
79	negative regulation of telomere maintenance (GO:0032205)	2.55990956
80	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.54720650
81	protein-cofactor linkage (GO:0018065)	2.54358247
82	maturation of 5.8S rRNA (GO:0000460)	2.52007214
83	ubiquinone biosynthetic process (GO:0006744)	2.51862809
84	GPI anchor metabolic process (GO:0006505)	2.50773386
85	hydrogen transport (GO:0006818)	2.50712653
86	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.48018318
87	pseudouridine synthesis (GO:0001522)	2.47887714
88	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.46947159
89	metallo-sulfur cluster assembly (GO:0031163)	2.45503163
90	iron-sulfur cluster assembly (GO:0016226)	2.45503163
91	regulation of cilium movement (GO:0003352)	2.43092854
92	ncRNA catabolic process (GO:0034661)	2.41892784
93	positive regulation of T cell apoptotic process (GO:0070234)	2.41277269
94	tryptophan metabolic process (GO:0006568)	2.41119754
95	preassembly of GPI anchor in ER membrane (GO:0016254)	2.40194419
96	ribosome biogenesis (GO:0042254)	2.38747237
97	tRNA processing (GO:0008033)	2.37564650
98	positive regulation of prostaglandin secretion (GO:0032308)	2.34971945
99	negative regulation of T cell differentiation in thymus (GO:0033085)	2.34682894
100	positive regulation of fatty acid transport (GO:2000193)	2.33943167

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.54042805
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.31025031
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.28256257
4	VDR_22108803_ChIP-Seq_LS180_Human	3.13873332
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.83423412
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.80738440
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.77057458
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.70085198
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.63879515
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.52162041
11	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.29077913
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.11018260
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.03433995
14	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.01259851
15	IGF1R_20145208_ChIP-Seq_DFB_Human	2.01077280
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.98074281
17	MYC_18940864_ChIP-ChIP_HL60_Human	1.90782807
18	VDR_23849224_ChIP-Seq_CD4+_Human	1.90699233
19	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.85831474
20	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.82791882
21	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.81549136
22	EWS_26573619_Chip-Seq_HEK293_Human	1.77943680
23	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.72004181
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.70929330
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.63757035
26	FUS_26573619_Chip-Seq_HEK293_Human	1.59669105
27	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.59067093
28	FOXP3_21729870_ChIP-Seq_TREG_Human	1.58909902
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.58713012
30	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.52444117
31	ELK1_19687146_ChIP-ChIP_HELA_Human	1.48036552
32	P300_19829295_ChIP-Seq_ESCs_Human	1.47778744
33	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.45635226
34	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.42717689
35	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.42047850
36	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.42047850
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.41682655
38	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.40930801
39	IRF1_19129219_ChIP-ChIP_H3396_Human	1.38302077
40	GBX2_23144817_ChIP-Seq_PC3_Human	1.38277999
41	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.36849803
42	CBP_20019798_ChIP-Seq_JUKART_Human	1.36262663
43	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.36262663
44	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.34280049
45	NCOR_22424771_ChIP-Seq_293T_Human	1.33102981
46	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.33057320
47	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.31613456
48	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.30618823
49	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.30291467
50	NANOG_20526341_ChIP-Seq_ESCs_Human	1.28756077
51	AR_20517297_ChIP-Seq_VCAP_Human	1.28122494
52	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.28034227
53	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.27509784
54	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.27429546
55	ER_23166858_ChIP-Seq_MCF-7_Human	1.26727292
56	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.25552487
57	TAF2_19829295_ChIP-Seq_ESCs_Human	1.23464761
58	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.21099575
59	MYC_19829295_ChIP-Seq_ESCs_Human	1.20535292
60	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.19635447
61	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.19151773
62	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.17623708
63	SOX2_19829295_ChIP-Seq_ESCs_Human	1.17017947
64	NANOG_19829295_ChIP-Seq_ESCs_Human	1.17017947
65	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.16317057
66	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.13212733
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12448257
68	TAF15_26573619_Chip-Seq_HEK293_Human	1.12317634
69	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.11878514
70	TTF2_22483619_ChIP-Seq_HELA_Human	1.11010683
71	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.08081334
72	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.07689876
73	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.07225125
74	RNF2_27304074_Chip-Seq_NSC_Mouse	1.07153370
75	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.06866308
76	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.05457438
77	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.04664313
78	BCAT_22108803_ChIP-Seq_LS180_Human	1.03542040
79	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.03127075
80	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.02994496
81	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.02213143
82	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.01472642
83	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.01245961
84	REST_21632747_ChIP-Seq_MESCs_Mouse	1.00054473
85	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.97932135
86	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.97787055
87	TCF4_22108803_ChIP-Seq_LS180_Human	0.96050411
88	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.95680500
89	HTT_18923047_ChIP-ChIP_STHdh_Human	0.94975266
90	ERG_20517297_ChIP-Seq_VCAP_Human	0.93185456
91	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.93157117
92	ERA_21632823_ChIP-Seq_H3396_Human	0.92273808
93	P53_21459846_ChIP-Seq_SAOS-2_Human	0.92082994
94	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.92031187
95	HOXB7_26014856_ChIP-Seq_BT474_Human	0.90031263
96	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.89081160
97	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.88674662
98	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.87077584
99	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.86383716
100	RBPJ_21746931_ChIP-Seq_IB4_Human	0.85460380

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.05016740
2	MP0009379_abnormal_foot_pigmentation	3.32189113
3	MP0002163_abnormal_gland_morphology	2.90173151
4	MP0002837_dystrophic_cardiac_calcinosis	2.86426726
5	MP0003787_abnormal_imprinting	2.53099355
6	MP0002653_abnormal_ependyma_morphology	2.39833309
7	MP0005671_abnormal_response_to	2.36215277
8	MP0005646_abnormal_pituitary_gland	2.33162073
9	MP0008877_abnormal_DNA_methylation	2.27197153
10	MP0005645_abnormal_hypothalamus_physiol	2.22305498
11	MP0002102_abnormal_ear_morphology	2.21148938
12	MP0004147_increased_porphyrin_level	2.11873441
13	MP0005084_abnormal_gallbladder_morpholo	2.04562630
14	MP0004142_abnormal_muscle_tone	1.99985228
15	MP0006276_abnormal_autonomic_nervous	1.97835925
16	MP0003646_muscle_fatigue	1.90153049
17	MP0001986_abnormal_taste_sensitivity	1.85571713
18	MP0008872_abnormal_physiological_respon	1.85252024
19	MP0004885_abnormal_endolymph	1.84637878
20	MP0005379_endocrine/exocrine_gland_phen	1.84470033
21	MP0005551_abnormal_eye_electrophysiolog	1.74556382
22	MP0003878_abnormal_ear_physiology	1.71320036
23	MP0005377_hearing/vestibular/ear_phenot	1.71320036
24	MP0004145_abnormal_muscle_electrophysio	1.62249365
25	MP0003195_calcinosis	1.61316937
26	MP0002160_abnormal_reproductive_system	1.59166903
27	MP0008789_abnormal_olfactory_epithelium	1.55959150
28	MP0003880_abnormal_central_pattern	1.53359336
29	MP0008875_abnormal_xenobiotic_pharmacok	1.53063814
30	MP0002638_abnormal_pupillary_reflex	1.51821675
31	MP0001968_abnormal_touch/_nociception	1.49511468
32	MP0006072_abnormal_retinal_apoptosis	1.47402265
33	MP0005389_reproductive_system_phenotype	1.42456987
34	MP0002876_abnormal_thyroid_physiology	1.38688839
35	MP0001835_abnormal_antigen_presentation	1.34878742
36	MP0003122_maternal_imprinting	1.31296076
37	MP0001905_abnormal_dopamine_level	1.30469275
38	MP0001485_abnormal_pinna_reflex	1.30462810
39	MP0002272_abnormal_nervous_system	1.27678880
40	MP0000372_irregular_coat_pigmentation	1.26544101
41	MP0000631_abnormal_neuroendocrine_gland	1.26422147
42	MP0005075_abnormal_melanosome_morpholog	1.23789384
43	MP0002938_white_spotting	1.21835135
44	MP0002736_abnormal_nociception_after	1.19907038
45	MP0002138_abnormal_hepatobiliary_system	1.18730353
46	MP0003186_abnormal_redox_activity	1.17339613
47	MP0003123_paternal_imprinting	1.14855488
48	MP0003121_genomic_imprinting	1.14708230
49	MP0009785_altered_susceptibility_to	1.13940422
50	MP0001764_abnormal_homeostasis	1.11722740
51	MP0006054_spinal_hemorrhage	1.11037030
52	MP0003011_delayed_dark_adaptation	1.09518334
53	MP0009745_abnormal_behavioral_response	1.09298724
54	MP0005423_abnormal_somatic_nervous	1.07172301
55	MP0001293_anophthalmia	1.03214439
56	MP0001529_abnormal_vocalization	1.02874675
57	MP0000049_abnormal_middle_ear	1.01862695
58	MP0001919_abnormal_reproductive_system	1.01632199
59	MP0003567_abnormal_fetal_cardiomyocyte	1.01180459
60	MP0005499_abnormal_olfactory_system	1.00554308
61	MP0005394_taste/olfaction_phenotype	1.00554308
62	MP0002277_abnormal_respiratory_mucosa	0.96527078
63	MP0001873_stomach_inflammation	0.95585248
64	MP0002693_abnormal_pancreas_physiology	0.94116101
65	MP0001188_hyperpigmentation	0.92734413
66	MP0002735_abnormal_chemical_nociception	0.92122046
67	MP0001984_abnormal_olfaction	0.90640104
68	MP0009333_abnormal_splenocyte_physiolog	0.90592521
69	MP0001800_abnormal_humoral_immune	0.90439597
70	MP0001970_abnormal_pain_threshold	0.87867295
71	MP0002095_abnormal_skin_pigmentation	0.87262658
72	MP0005253_abnormal_eye_physiology	0.87262594
73	MP0005636_abnormal_mineral_homeostasis	0.87255418
74	MP0009046_muscle_twitch	0.87033171
75	MP0002733_abnormal_thermal_nociception	0.86788781
76	MP0002557_abnormal_social/conspecific_i	0.84201237
77	MP0004133_heterotaxia	0.83017303
78	MP0003806_abnormal_nucleotide_metabolis	0.82822006
79	MP0005410_abnormal_fertilization	0.82365471
80	MP0003283_abnormal_digestive_organ	0.82266911
81	MP0000026_abnormal_inner_ear	0.82087985
82	MP0003866_abnormal_defecation	0.81943719
83	MP0001963_abnormal_hearing_physiology	0.81662346
84	MP0001440_abnormal_grooming_behavior	0.81036553
85	MP0003136_yellow_coat_color	0.79963043
86	MP0002234_abnormal_pharynx_morphology	0.79856734
87	MP0002822_catalepsy	0.78908825
88	MP0008775_abnormal_heart_ventricle	0.77764073
89	MP0002752_abnormal_somatic_nervous	0.77250132
90	MP0004742_abnormal_vestibular_system	0.75676304
91	MP0005195_abnormal_posterior_eye	0.74859320
92	MP0008995_early_reproductive_senescence	0.74760985
93	MP0001486_abnormal_startle_reflex	0.74489779
94	MP0002148_abnormal_hypersensitivity_rea	0.70509929
95	MP0002184_abnormal_innervation	0.70144789
96	MP0001944_abnormal_pancreas_morphology	0.69205594
97	MP0002572_abnormal_emotion/affect_behav	0.68380822
98	MP0005174_abnormal_tail_pigmentation	0.68162258
99	MP0005332_abnormal_amino_acid	0.67894782
100	MP0002723_abnormal_immune_serum	0.64810817

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.41618867
2	Acute necrotizing encephalopathy (HP:0006965)	4.34386548
3	Abnormality of cells of the erythroid lineage (HP:0012130)	3.94005889
4	Mitochondrial inheritance (HP:0001427)	3.93956665
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.81320360
6	Abnormal rod and cone electroretinograms (HP:0008323)	3.78318192
7	Acute encephalopathy (HP:0006846)	3.68205947
8	Progressive macrocephaly (HP:0004481)	3.67475191
9	Congenital stationary night blindness (HP:0007642)	3.58178344
10	Abnormal number of erythroid precursors (HP:0012131)	3.45970826
11	Pancreatic cysts (HP:0001737)	3.42865099
12	Increased CSF lactate (HP:0002490)	3.40534122
13	Reticulocytopenia (HP:0001896)	3.40501080
14	Pancreatic fibrosis (HP:0100732)	3.37804829
15	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.29087979
16	Absent/shortened dynein arms (HP:0200106)	3.29087979
17	Increased hepatocellular lipid droplets (HP:0006565)	3.24830346
18	Hepatocellular necrosis (HP:0001404)	3.20465744
19	True hermaphroditism (HP:0010459)	3.12750938
20	Macrocytic anemia (HP:0001972)	3.12430589
21	Abnormality of midbrain morphology (HP:0002418)	3.08710908
22	Molar tooth sign on MRI (HP:0002419)	3.08710908
23	Decreased central vision (HP:0007663)	2.98511445
24	Lipid accumulation in hepatocytes (HP:0006561)	2.91895609
25	Hepatic necrosis (HP:0002605)	2.90521474
26	Optic disc pallor (HP:0000543)	2.90501822
27	Abolished electroretinogram (ERG) (HP:0000550)	2.81644945
28	Constricted visual fields (HP:0001133)	2.78526405
29	Cerebral edema (HP:0002181)	2.78268859
30	Nephronophthisis (HP:0000090)	2.76281855
31	Renal Fanconi syndrome (HP:0001994)	2.68483781
32	3-Methylglutaconic aciduria (HP:0003535)	2.67743794
33	Increased intramyocellular lipid droplets (HP:0012240)	2.59913005
34	Abnormal respiratory epithelium morphology (HP:0012253)	2.55247001
35	Abnormal respiratory motile cilium morphology (HP:0005938)	2.55247001
36	Pallor (HP:0000980)	2.54829250
37	Attenuation of retinal blood vessels (HP:0007843)	2.54576301
38	Pendular nystagmus (HP:0012043)	2.45461877
39	Medial flaring of the eyebrow (HP:0010747)	2.44575689
40	Exertional dyspnea (HP:0002875)	2.42126669
41	Methylmalonic acidemia (HP:0002912)	2.41658795
42	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.40398855
43	Abnormal ciliary motility (HP:0012262)	2.35117078
44	IgG deficiency (HP:0004315)	2.34556486
45	Abnormality of the renal cortex (HP:0011035)	2.32796741
46	Elevated erythrocyte sedimentation rate (HP:0003565)	2.28811696
47	Stenosis of the external auditory canal (HP:0000402)	2.26826885
48	Abnormal hemoglobin (HP:0011902)	2.26239942
49	Abnormality of the renal medulla (HP:0100957)	2.25709793
50	Increased serum lactate (HP:0002151)	2.24536169
51	Sclerocornea (HP:0000647)	2.18100558
52	Hypoproteinemia (HP:0003075)	2.15360776
53	Aplastic anemia (HP:0001915)	2.14933988
54	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.13218074
55	Type II lissencephaly (HP:0007260)	2.12842572
56	Lactic acidosis (HP:0003128)	2.12775099
57	Absent thumb (HP:0009777)	2.11416163
58	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.09296277
59	Methylmalonic aciduria (HP:0012120)	2.09045355
60	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.08303919
61	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.08303919
62	Severe combined immunodeficiency (HP:0004430)	2.08298183
63	Colon cancer (HP:0003003)	2.05779789
64	Increased muscle lipid content (HP:0009058)	2.05583104
65	Abnormality of renal resorption (HP:0011038)	2.04574382
66	Renal cortical cysts (HP:0000803)	2.04175644
67	Cystic liver disease (HP:0006706)	2.04032215
68	Increased corneal curvature (HP:0100692)	2.03094967
69	Keratoconus (HP:0000563)	2.03094967
70	Thyroiditis (HP:0100646)	2.02761856
71	Abnormal respiratory motile cilium physiology (HP:0012261)	2.01916358
72	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.00840137
73	Respiratory failure (HP:0002878)	1.97606364
74	Gait imbalance (HP:0002141)	1.94495740
75	Postaxial foot polydactyly (HP:0001830)	1.94267181
76	Glycosuria (HP:0003076)	1.93948256
77	Abnormality of urine glucose concentration (HP:0011016)	1.93948256
78	Congenital primary aphakia (HP:0007707)	1.93353655
79	Anencephaly (HP:0002323)	1.93239687
80	Polydipsia (HP:0001959)	1.92243514
81	Abnormal drinking behavior (HP:0030082)	1.92243514
82	Chronic hepatic failure (HP:0100626)	1.91496385
83	Stomatitis (HP:0010280)	1.90200068
84	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.89185474
85	Lethargy (HP:0001254)	1.89111767
86	Triphalangeal thumb (HP:0001199)	1.89075620
87	Male pseudohermaphroditism (HP:0000037)	1.88789194
88	Bony spicule pigmentary retinopathy (HP:0007737)	1.87420774
89	Leukodystrophy (HP:0002415)	1.85911489
90	Septo-optic dysplasia (HP:0100842)	1.84700317
91	Hypoplasia of the uterus (HP:0000013)	1.83878679
92	Polyuria (HP:0000103)	1.83245788
93	Nephrogenic diabetes insipidus (HP:0009806)	1.80249541
94	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.78816949
95	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.76392083
96	Exercise intolerance (HP:0003546)	1.75765787
97	Hyperglycinemia (HP:0002154)	1.75269621
98	Aplasia/hypoplasia of the uterus (HP:0008684)	1.74742178
99	Asplenia (HP:0001746)	1.73459080
100	Abnormality of DNA repair (HP:0003254)	1.73143364

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.56365453
2	TXK	3.47046155
3	PASK	3.21429353
4	FRK	2.99802637
5	CDK19	2.99683736
6	ZAK	2.68670675
7	GRK1	2.66354027
8	ADRBK2	2.52789755
9	TLK1	2.42076943
10	STK16	2.34738428
11	WNK4	2.12526170
12	NUAK1	2.02642012
13	PINK1	1.93196067
14	WNK3	1.92256466
15	TIE1	1.66274752
16	BCKDK	1.59823627
17	VRK2	1.59594117
18	KDR	1.50177898
19	DYRK2	1.45357003
20	TEC	1.38816468
21	VRK1	1.35871420
22	MAP3K9	1.35540111
23	ITK	1.32486815
24	INSRR	1.30407958
25	KIT	1.21854447
26	MAP2K6	1.21401626
27	OXSR1	1.11715742
28	CAMKK1	1.11601610
29	MAP4K1	1.10477110
30	TNIK	1.07662336
31	TAOK3	1.03616116
32	MST4	1.02837163
33	BMPR1B	1.02597081
34	TNK2	1.02154935
35	CAMKK2	1.01177989
36	PRKCQ	0.98249938
37	IKBKB	0.92452993
38	CASK	0.92300220
39	SYK	0.87127704
40	PIK3CA	0.85961039
41	STK39	0.85443806
42	BTK	0.82996531
43	PIK3CG	0.82353699
44	RPS6KA5	0.80920972
45	DAPK2	0.78535803
46	NLK	0.77558557
47	CSNK1G1	0.77074421
48	PLK4	0.75873524
49	LIMK1	0.74604996
50	ADRBK1	0.74467227
51	PRKCG	0.71303310
52	MAP3K4	0.70468704
53	MATK	0.70292368
54	MAP2K7	0.67952076
55	TRIM28	0.67884362
56	CAMK1	0.63283792
57	PLK2	0.63000603
58	SIK2	0.62540675
59	PRKCE	0.62011485
60	OBSCN	0.61360902
61	LCK	0.61159945
62	MARK1	0.59387041
63	CSNK1G3	0.58743944
64	MAPK13	0.57971703
65	RPS6KA4	0.56880931
66	CSNK1G2	0.56120853
67	NME1	0.54835270
68	CSNK2A2	0.54030201
69	MKNK1	0.53865853
70	LYN	0.53456379
71	PRKACA	0.51982661
72	MAP3K11	0.50503041
73	CDK3	0.48470872
74	MUSK	0.48178203
75	CSF1R	0.48060592
76	PLK3	0.47921551
77	RPS6KA6	0.47679590
78	TAF1	0.47326378
79	NTRK2	0.46806497
80	FLT3	0.46690008
81	EPHA4	0.46204585
82	PRKCH	0.46003478
83	PRKCA	0.45823258
84	NME2	0.44973835
85	TRPM7	0.43887836
86	PIM1	0.42385330
87	BUB1	0.41651641
88	AURKA	0.41433766
89	PAK3	0.41126052
90	IGF1R	0.40390136
91	CSNK2A1	0.40348158
92	PLK1	0.40107205
93	DAPK3	0.39989446
94	FES	0.39112788
95	IKBKE	0.38402631
96	GRK7	0.37869781
97	NEK2	0.37790201
98	TGFBR1	0.36311082
99	JAK3	0.35835437
100	CSNK1A1	0.34857376

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.39078728
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.87741449
3	Parkinsons disease_Homo sapiens_hsa05012	3.03049677
4	Proteasome_Homo sapiens_hsa03050	2.53590371
5	RNA polymerase_Homo sapiens_hsa03020	2.30749273
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.21847030
7	Asthma_Homo sapiens_hsa05310	2.18422863
8	Protein export_Homo sapiens_hsa03060	2.11958195
9	Primary immunodeficiency_Homo sapiens_hsa05340	2.06992263
10	Linoleic acid metabolism_Homo sapiens_hsa00591	2.05435318
11	Huntingtons disease_Homo sapiens_hsa05016	1.99931178
12	Alzheimers disease_Homo sapiens_hsa05010	1.98317251
13	Allograft rejection_Homo sapiens_hsa05330	1.98263920
14	Phototransduction_Homo sapiens_hsa04744	1.90885030
15	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.90000643
16	Cardiac muscle contraction_Homo sapiens_hsa04260	1.89647758
17	Type I diabetes mellitus_Homo sapiens_hsa04940	1.82922841
18	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.82474533
19	RNA degradation_Homo sapiens_hsa03018	1.78568918
20	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.76810450
21	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.76803400
22	Graft-versus-host disease_Homo sapiens_hsa05332	1.69017424
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.58689660
24	One carbon pool by folate_Homo sapiens_hsa00670	1.57926549
25	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.56558781
26	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.48157766
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.46050337
28	Homologous recombination_Homo sapiens_hsa03440	1.43105010
29	Propanoate metabolism_Homo sapiens_hsa00640	1.32655353
30	Basal transcription factors_Homo sapiens_hsa03022	1.30214420
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.22093142
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.16388186
33	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.15498078
34	Nicotine addiction_Homo sapiens_hsa05033	1.14063707
35	Butanoate metabolism_Homo sapiens_hsa00650	1.12455620
36	Pyrimidine metabolism_Homo sapiens_hsa00240	1.07971096
37	Caffeine metabolism_Homo sapiens_hsa00232	1.07311438
38	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.02677926
39	Olfactory transduction_Homo sapiens_hsa04740	1.01766161
40	Retinol metabolism_Homo sapiens_hsa00830	1.01471855
41	Peroxisome_Homo sapiens_hsa04146	1.00498969
42	Ether lipid metabolism_Homo sapiens_hsa00565	1.00466599
43	Fanconi anemia pathway_Homo sapiens_hsa03460	0.99741809
44	Rheumatoid arthritis_Homo sapiens_hsa05323	0.97541230
45	Tryptophan metabolism_Homo sapiens_hsa00380	0.96400849
46	Antigen processing and presentation_Homo sapiens_hsa04612	0.95166335
47	Fat digestion and absorption_Homo sapiens_hsa04975	0.94367799
48	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.93362584
49	Purine metabolism_Homo sapiens_hsa00230	0.92217322
50	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.89944671
51	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.87409079
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.85660253
53	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.84755217
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.84438635
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.83960801
56	Nucleotide excision repair_Homo sapiens_hsa03420	0.78930211
57	Taste transduction_Homo sapiens_hsa04742	0.76756175
58	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.75432454
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.72917529
60	Collecting duct acid secretion_Homo sapiens_hsa04966	0.72600454
61	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.70293081
62	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.68995106
63	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.67739424
64	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.67683923
65	RNA transport_Homo sapiens_hsa03013	0.65838467
66	Metabolic pathways_Homo sapiens_hsa01100	0.65717655
67	Regulation of autophagy_Homo sapiens_hsa04140	0.64637177
68	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.64517920
69	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.61357923
70	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.59505414
71	Morphine addiction_Homo sapiens_hsa05032	0.59006323
72	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.57798652
73	Mismatch repair_Homo sapiens_hsa03430	0.57244150
74	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.57227559
75	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.47787073
76	Spliceosome_Homo sapiens_hsa03040	0.46587609
77	Fatty acid elongation_Homo sapiens_hsa00062	0.45826761
78	GABAergic synapse_Homo sapiens_hsa04727	0.44532553
79	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.44034363
80	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.43611768
81	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.43370711
82	Insulin secretion_Homo sapiens_hsa04911	0.42175419
83	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.41721216
84	Selenocompound metabolism_Homo sapiens_hsa00450	0.41373263
85	Base excision repair_Homo sapiens_hsa03410	0.40205152
86	Serotonergic synapse_Homo sapiens_hsa04726	0.39886251
87	Fatty acid degradation_Homo sapiens_hsa00071	0.38800396
88	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.37901753
89	Salivary secretion_Homo sapiens_hsa04970	0.37521816
90	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.35722514
91	beta-Alanine metabolism_Homo sapiens_hsa00410	0.34666088
92	Sulfur relay system_Homo sapiens_hsa04122	0.33767510
93	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.32952015
94	DNA replication_Homo sapiens_hsa03030	0.32883904
95	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.32638726
96	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.32143610
97	Glycerolipid metabolism_Homo sapiens_hsa00561	0.29928707
98	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.29596572
99	Circadian entrainment_Homo sapiens_hsa04713	0.24255863
100	Glutamatergic synapse_Homo sapiens_hsa04724	0.22017933

RPL5P9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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