RPL6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein component of the 60S ribosomal subunit. This protein can bind specifically to domain C of the tax-responsive enhancer element of human T-cell leukemia virus type 1, and may participate in tax-mediated transactivation of transcription. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.45886356
2* viral transcription (GO:0019083)7.34395390
3* translational termination (GO:0006415)7.12593163
4ribosomal small subunit biogenesis (GO:0042274)6.52223017
5maturation of SSU-rRNA (GO:0030490)6.31989048
6* translational elongation (GO:0006414)6.26782194
7* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.01062330
8* cotranslational protein targeting to membrane (GO:0006613)5.89080801
9* protein targeting to ER (GO:0045047)5.87824820
10* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.77469989
11* translational initiation (GO:0006413)5.70439049
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.61741559
13* establishment of protein localization to endoplasmic reticulum (GO:0072599)5.61389956
14* cellular protein complex disassembly (GO:0043624)5.55286328
15* viral life cycle (GO:0019058)5.53919696
16* protein localization to endoplasmic reticulum (GO:0070972)5.49681342
17ribosomal large subunit biogenesis (GO:0042273)5.39053928
18ATP synthesis coupled proton transport (GO:0015986)5.17360224
19energy coupled proton transport, down electrochemical gradient (GO:0015985)5.17360224
20* protein complex disassembly (GO:0043241)4.96321678
21formation of translation preinitiation complex (GO:0001731)4.90640403
22* macromolecular complex disassembly (GO:0032984)4.65586832
23DNA unwinding involved in DNA replication (GO:0006268)4.52460207
24ribonucleoprotein complex biogenesis (GO:0022613)4.47960805
25DNA strand elongation involved in DNA replication (GO:0006271)4.40620949
26* nuclear-transcribed mRNA catabolic process (GO:0000956)4.32353873
27DNA strand elongation (GO:0022616)4.17686171
28establishment of protein localization to mitochondrial membrane (GO:0090151)4.13111888
29* translation (GO:0006412)4.12996862
30* mRNA catabolic process (GO:0006402)4.09813657
31DNA replication initiation (GO:0006270)4.08290008
32telomere maintenance via semi-conservative replication (GO:0032201)4.08082371
33* protein targeting (GO:0006605)4.01996228
34* establishment of protein localization to organelle (GO:0072594)3.97650725
35* RNA catabolic process (GO:0006401)3.92362273
36* protein targeting to membrane (GO:0006612)3.86042806
37chaperone-mediated protein transport (GO:0072321)3.75265832
38rRNA processing (GO:0006364)3.74511647
39DNA deamination (GO:0045006)3.73955501
40nucleobase biosynthetic process (GO:0046112)3.70980467
41rRNA metabolic process (GO:0016072)3.61459358
42* protein localization to membrane (GO:0072657)3.59503393
43telomere maintenance via recombination (GO:0000722)3.57397588
44IMP biosynthetic process (GO:0006188)3.44704611
45folic acid-containing compound biosynthetic process (GO:0009396)3.44212237
46protein localization to kinetochore (GO:0034501)3.43800973
47ribosome assembly (GO:0042255)3.42872550
48ribosome biogenesis (GO:0042254)3.41712126
49mitotic recombination (GO:0006312)3.40949905
50establishment of integrated proviral latency (GO:0075713)3.36393025
51purine nucleobase biosynthetic process (GO:0009113)3.33173407
52telomere maintenance via telomere lengthening (GO:0010833)3.31132512
53DNA replication checkpoint (GO:0000076)3.30827220
54spliceosomal snRNP assembly (GO:0000387)3.28096173
55respiratory electron transport chain (GO:0022904)3.27358050
56cellular component biogenesis (GO:0044085)3.27233416
57mitotic nuclear envelope disassembly (GO:0007077)3.22192491
58electron transport chain (GO:0022900)3.19861344
59nucleotide-excision repair, DNA gap filling (GO:0006297)3.19799111
60negative regulation of RNA splicing (GO:0033119)3.17730117
61CENP-A containing nucleosome assembly (GO:0034080)3.16412011
62DNA replication-dependent nucleosome organization (GO:0034723)3.15916524
63DNA replication-dependent nucleosome assembly (GO:0006335)3.15916524
64chromatin remodeling at centromere (GO:0031055)3.13219739
65inner mitochondrial membrane organization (GO:0007007)3.13127860
66IMP metabolic process (GO:0046040)3.11639165
67mitotic metaphase plate congression (GO:0007080)3.07997516
68* protein localization to organelle (GO:0033365)3.07694387
69pseudouridine synthesis (GO:0001522)3.03071433
70protein localization to chromosome, centromeric region (GO:0071459)3.00843369
71DNA replication-independent nucleosome organization (GO:0034724)3.00309268
72DNA replication-independent nucleosome assembly (GO:0006336)3.00309268
73mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.96782205
74negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.96768490
75* cellular component disassembly (GO:0022411)2.96463845
76nuclear envelope disassembly (GO:0051081)2.95747848
77membrane disassembly (GO:0030397)2.95747848
78heterochromatin organization (GO:0070828)2.91268776
79negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.89108812
80regulation of mitochondrial translation (GO:0070129)2.88845258
81spliceosomal complex assembly (GO:0000245)2.88377574
82mRNA splicing, via spliceosome (GO:0000398)2.85966577
83RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.85966577
84anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.85593461
85RNA splicing, via transesterification reactions (GO:0000375)2.85458639
86proteasome assembly (GO:0043248)2.84247190
87regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.82482063
88transcription-coupled nucleotide-excision repair (GO:0006283)2.82272116
89regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.82077148
90kinetochore organization (GO:0051383)2.81930409
91positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.81044145
92metaphase plate congression (GO:0051310)2.80142635
93ncRNA 3-end processing (GO:0043628)2.79981525
94regulation of translational fidelity (GO:0006450)2.79089077
95mitotic chromosome condensation (GO:0007076)2.78692095
96DNA duplex unwinding (GO:0032508)2.78315402
97DNA geometric change (GO:0032392)2.76325153
98negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.75119082
99negative regulation of ligase activity (GO:0051352)2.75119082
100nuclear pore organization (GO:0006999)2.74285088
101ncRNA processing (GO:0034470)2.72664958
102termination of RNA polymerase II transcription (GO:0006369)2.70268831
103ribonucleoprotein complex assembly (GO:0022618)2.69860781
104oxidative phosphorylation (GO:0006119)2.68891434
105deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.67202121
106viral mRNA export from host cell nucleus (GO:0046784)2.66088264
107ATP biosynthetic process (GO:0006754)2.65148932
108regulation of spindle organization (GO:0090224)2.64791757
109G1/S transition of mitotic cell cycle (GO:0000082)2.64594141
110cell cycle G1/S phase transition (GO:0044843)2.64594141
111exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.63465037
112DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.62781427
113termination of RNA polymerase III transcription (GO:0006386)2.62524242
114transcription elongation from RNA polymerase III promoter (GO:0006385)2.62524242
115DNA topological change (GO:0006265)2.62251954
116* establishment of protein localization to membrane (GO:0090150)2.62219342
117mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.61573756
118mitochondrial respiratory chain complex I assembly (GO:0032981)2.61573756
119NADH dehydrogenase complex assembly (GO:0010257)2.61573756
120ribonucleoprotein complex subunit organization (GO:0071826)2.60794910
121sequestering of actin monomers (GO:0042989)2.60435279
122intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.59775215
123signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.59775215
124ncRNA metabolic process (GO:0034660)2.59770422
125* gene expression (GO:0010467)2.59633658
126signal transduction involved in DNA integrity checkpoint (GO:0072401)2.57812719
127purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.56384333
128protein neddylation (GO:0045116)2.53543149
129mitochondrial respiratory chain complex assembly (GO:0033108)2.53535562
130purine nucleoside triphosphate biosynthetic process (GO:0009145)2.52544625
131protein complex biogenesis (GO:0070271)2.51404776
132ribonucleoside triphosphate biosynthetic process (GO:0009201)2.49726928
133pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.48707149
134myeloid cell homeostasis (GO:0002262)2.48143841
135UTP biosynthetic process (GO:0006228)2.45258465
136DNA damage response, detection of DNA damage (GO:0042769)2.43923470
137mitotic sister chromatid segregation (GO:0000070)2.34534015
138GTP biosynthetic process (GO:0006183)2.28629767
139pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.28428789
140UTP metabolic process (GO:0046051)2.28338832
141pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.27351407
142positive regulation of viral transcription (GO:0050434)2.26080499
143negative regulation of DNA repair (GO:0045738)2.25573440
144sister chromatid segregation (GO:0000819)2.25308063

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.58902010
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.70182987
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.03388100
4* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.37921736
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.23761571
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.22101942
7* EST1_17652178_ChIP-ChIP_JURKAT_Human3.02935559
8* ETS1_20019798_ChIP-Seq_JURKAT_Human2.89123360
9* GABP_17652178_ChIP-ChIP_JURKAT_Human2.89084448
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.88962009
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.87163080
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.79934540
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.79269570
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.77293620
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.61299044
16* XRN2_22483619_ChIP-Seq_HELA_Human2.61247250
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.52902613
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.51353724
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.33292439
20* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28598185
21VDR_23849224_ChIP-Seq_CD4+_Human2.27207608
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.23544714
23* TTF2_22483619_ChIP-Seq_HELA_Human2.05435128
24FOXP3_21729870_ChIP-Seq_TREG_Human2.04351611
25DCP1A_22483619_ChIP-Seq_HELA_Human2.00797332
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.00751759
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99094137
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.92889367
29* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92292435
30MYC_22102868_ChIP-Seq_BL_Human1.90494761
31* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.90279575
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.84074694
33GABP_19822575_ChIP-Seq_HepG2_Human1.78768274
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76824587
35CIITA_25753668_ChIP-Seq_RAJI_Human1.72305489
36ELK1_19687146_ChIP-ChIP_HELA_Human1.71755939
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.71303041
38* AR_21909140_ChIP-Seq_LNCAP_Human1.70671466
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69042161
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.66973248
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66597022
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66468992
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60341670
44* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57063241
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51834601
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50789795
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.49949607
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49102387
49* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46061472
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42573253
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41489070
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.40939947
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40262906
54* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37699988
55KDM5A_27292631_Chip-Seq_BREAST_Human1.36732744
56* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36569384
57VDR_21846776_ChIP-Seq_THP-1_Human1.35426270
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30735170
59KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.28267386
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27392506
61KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.25560228
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25021366
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24412268
64* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22996732
65SOX2_16153702_ChIP-ChIP_HESCs_Human1.20636500
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.20241471
67SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.19419738
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16807809
69ZNF263_19887448_ChIP-Seq_K562_Human1.14906745
70TFEB_21752829_ChIP-Seq_HELA_Human1.14348259
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.14276069
72* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13366208
73ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10522978
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09193001
75CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07736445
76SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07592624
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06632235
78* ELK1_22589737_ChIP-Seq_MCF10A_Human1.06482646
79* SPI1_23547873_ChIP-Seq_NB4_Human1.05890265
80CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04594447
81KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04188139
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03589521
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02903913
84TP63_17297297_ChIP-ChIP_HaCaT_Human1.01787551
85MYC_18940864_ChIP-ChIP_HL60_Human1.01700657
86RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01534741
87PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98432083
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98218086
89CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98145964
90POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96115620
91* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95624406
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95269092
93PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94708730
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93924414
95TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93800694
96SOX17_20123909_ChIP-Seq_XEN_Mouse0.93423172
97* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92181873
98NANOG_16153702_ChIP-ChIP_HESCs_Human0.91296312
99TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91059894
100NANOG_21062744_ChIP-ChIP_HESCs_Human0.90951658
101TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.90548201
102* TP63_19390658_ChIP-ChIP_HaCaT_Human0.90512769
103OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89259596
104CBX2_27304074_Chip-Seq_ESCs_Mouse0.89238236
105* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86830082
106FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.85150383
107CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84956612
108SRY_22984422_ChIP-ChIP_TESTIS_Rat0.84668631
109ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.83389540
110KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.82900171
111KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.82900171
112KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.82900171
113FOXP1_21924763_ChIP-Seq_HESCs_Human0.82850477
114SOX2_18692474_ChIP-Seq_MEFs_Mouse0.81903830
115SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81527460
116HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.80205979
117UTX_26944678_Chip-Seq_JUKART_Human0.79890853
118* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.79350227

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.94618990
2MP0004957_abnormal_blastocyst_morpholog4.26806080
3MP0010094_abnormal_chromosome_stability3.92557705
4MP0003111_abnormal_nucleus_morphology3.71429548
5MP0003077_abnormal_cell_cycle3.61061055
6MP0000566_synostosis3.58394240
7MP0006292_abnormal_olfactory_placode3.40513810
8MP0008057_abnormal_DNA_replication3.09898538
9MP0002396_abnormal_hematopoietic_system2.78503139
10MP0008058_abnormal_DNA_repair2.73395485
11MP0009379_abnormal_foot_pigmentation2.73044609
12MP0008007_abnormal_cellular_replicative2.57034469
13MP0003136_yellow_coat_color2.56167250
14MP0008932_abnormal_embryonic_tissue2.36239102
15MP0010352_gastrointestinal_tract_polyps2.25248764
16MP0001730_embryonic_growth_arrest2.14013146
17MP0003123_paternal_imprinting2.12572129
18MP0000350_abnormal_cell_proliferation2.07009339
19MP0000490_abnormal_crypts_of2.01314826
20MP0004808_abnormal_hematopoietic_stem1.88613565
21MP0002697_abnormal_eye_size1.83843615
22MP0003786_premature_aging1.79014107
23MP0001346_abnormal_lacrimal_gland1.78104223
24MP0003890_abnormal_embryonic-extraembry1.69774797
25MP0003763_abnormal_thymus_physiology1.68151032
26MP0000049_abnormal_middle_ear1.64816629
27MP0009333_abnormal_splenocyte_physiolog1.63074231
28MP0003567_abnormal_fetal_cardiomyocyte1.62307704
29MP0003937_abnormal_limbs/digits/tail_de1.61739429
30MP0008789_abnormal_olfactory_epithelium1.58294289
31MP0001697_abnormal_embryo_size1.56399186
32MP0003938_abnormal_ear_development1.55857383
33MP0002080_prenatal_lethality1.51700232
34MP0010307_abnormal_tumor_latency1.49602119
35MP0005380_embryogenesis_phenotype1.46274017
36MP0001672_abnormal_embryogenesis/_devel1.46274017
37MP0002019_abnormal_tumor_incidence1.46114437
38MP0008995_early_reproductive_senescence1.44480392
39MP0000313_abnormal_cell_death1.44264051
40MP0006054_spinal_hemorrhage1.42808768
41MP0001529_abnormal_vocalization1.42539660
42MP0001545_abnormal_hematopoietic_system1.38325887
43MP0005397_hematopoietic_system_phenotyp1.38325887
44MP0000703_abnormal_thymus_morphology1.37006220
45MP0002085_abnormal_embryonic_tissue1.36967049
46MP0005499_abnormal_olfactory_system1.34953480
47MP0005394_taste/olfaction_phenotype1.34953480
48MP0002084_abnormal_developmental_patter1.34654285
49MP0002234_abnormal_pharynx_morphology1.34646675
50MP0002163_abnormal_gland_morphology1.34257403
51MP0002398_abnormal_bone_marrow1.33984611
52MP0004197_abnormal_fetal_growth/weight/1.32400189
53MP0003984_embryonic_growth_retardation1.32181704
54MP0002088_abnormal_embryonic_growth/wei1.29861343
55MP0003942_abnormal_urinary_system1.28202818
56MP0002249_abnormal_larynx_morphology1.27100181
57MP0002722_abnormal_immune_system1.26642796
58MP0002086_abnormal_extraembryonic_tissu1.24683297
59MP0002233_abnormal_nose_morphology1.24046520
60MP0002653_abnormal_ependyma_morphology1.23430114
61MP0000631_abnormal_neuroendocrine_gland1.23204410
62MP0000537_abnormal_urethra_morphology1.22297699
63MP0002009_preneoplasia1.17786094
64MP0000689_abnormal_spleen_morphology1.16717841
65MP0000762_abnormal_tongue_morphology1.16682396
66MP0010030_abnormal_orbit_morphology1.16551216
67MP0000778_abnormal_nervous_system1.16431830
68MP0004185_abnormal_adipocyte_glucose1.14995490
69MP0003861_abnormal_nervous_system1.14560758
70MP0009250_abnormal_appendicular_skeleto1.14300135
71MP0003755_abnormal_palate_morphology1.13616254
72MP0001293_anophthalmia1.12894265
73MP0003315_abnormal_perineum_morphology1.12636935
74MP0000685_abnormal_immune_system1.08368646
75MP0006072_abnormal_retinal_apoptosis1.06881200
76MP0002429_abnormal_blood_cell1.05616358
77MP0005174_abnormal_tail_pigmentation1.03719295
78MP0000858_altered_metastatic_potential1.03394021
79MP0002160_abnormal_reproductive_system0.99550046
80MP0003718_maternal_effect0.99350096
81MP0002638_abnormal_pupillary_reflex0.99311466
82MP0008877_abnormal_DNA_methylation0.98357457
83MP0002938_white_spotting0.97784719
84MP0000465_gastrointestinal_hemorrhage0.97041833
85MP0003121_genomic_imprinting0.95985220
86MP0000716_abnormal_immune_system0.95246198
87MP0005023_abnormal_wound_healing0.94853389
88MP0002095_abnormal_skin_pigmentation0.94356483
89MP0003283_abnormal_digestive_organ0.94240846
90MP0003122_maternal_imprinting0.92914190
91MP0002166_altered_tumor_susceptibility0.92138213
92MP0005503_abnormal_tendon_morphology0.91842920
93MP0002132_abnormal_respiratory_system0.91751833
94MP0001800_abnormal_humoral_immune0.91593708
95MP0003941_abnormal_skin_development0.91429364
96MP0002116_abnormal_craniofacial_bone0.91148429
97MP0003385_abnormal_body_wall0.91036261
98MP0000358_abnormal_cell_content/0.90859175
99MP0002932_abnormal_joint_morphology0.90703518
100MP0005391_vision/eye_phenotype0.88825033
101MP0009278_abnormal_bone_marrow0.87574900
102MP0003935_abnormal_craniofacial_develop0.86927180
103MP0005501_abnormal_skin_physiology0.86683535
104MP0001853_heart_inflammation0.85652562
105MP0001835_abnormal_antigen_presentation0.84396252
106MP0000026_abnormal_inner_ear0.84224515
107MP0004133_heterotaxia0.83021736
108MP0002420_abnormal_adaptive_immunity0.82811936
109MP0005075_abnormal_melanosome_morpholog0.82504716
110MP0005076_abnormal_cell_differentiation0.82108728
111MP0000477_abnormal_intestine_morphology0.81922293
112MP0002282_abnormal_trachea_morphology0.81601302
113MP0009672_abnormal_birth_weight0.81552284
114MP0009053_abnormal_anal_canal0.81546394
115MP0000534_abnormal_ureter_morphology0.81225824
116MP0003119_abnormal_digestive_system0.81089471
117MP0002111_abnormal_tail_morphology0.80704109
118MP0001819_abnormal_immune_cell0.80607358
119MP0004142_abnormal_muscle_tone0.79610546
120MP0002210_abnormal_sex_determination0.77284609
121MP0005671_abnormal_response_to0.76859638
122MP0002452_abnormal_antigen_presenting0.76705854
123MP0002006_tumorigenesis0.76438876
124MP0003186_abnormal_redox_activity0.74480004
125MP0003011_delayed_dark_adaptation0.74385688
126MP0003806_abnormal_nucleotide_metabolis0.74280778
127MP0001145_abnormal_male_reproductive0.74032148
128MP0001873_stomach_inflammation0.73757622
129MP0002405_respiratory_system_inflammati0.73732724
130MP0003566_abnormal_cell_adhesion0.73715823
131MP0002081_perinatal_lethality0.72673066
132MP0002277_abnormal_respiratory_mucosa0.72576142
133MP0010155_abnormal_intestine_physiology0.71959577
134MP0002109_abnormal_limb_morphology0.71870968
135MP0001727_abnormal_embryo_implantation0.71001723
136MP0002184_abnormal_innervation0.69870509
137MP0003866_abnormal_defecation0.69581283
138MP0005384_cellular_phenotype0.67992592
139MP0000955_abnormal_spinal_cord0.67027451
140MP0002723_abnormal_immune_serum0.66775089
141MP0001340_abnormal_eyelid_morphology0.66278819
142MP0001929_abnormal_gametogenesis0.64499038
143MP0002752_abnormal_somatic_nervous0.63919458
144MP0003115_abnormal_respiratory_system0.63875867
145MP0002092_abnormal_eye_morphology0.62924427
146MP0001849_ear_inflammation0.62532952
147MP0005621_abnormal_cell_physiology0.61853704
148MP0001286_abnormal_eye_development0.60843865
149MP0001915_intracranial_hemorrhage0.59261476
150MP0000428_abnormal_craniofacial_morphol0.57835868
151MP0000653_abnormal_sex_gland0.57266447
152MP0010234_abnormal_vibrissa_follicle0.56446644
153MP0005025_abnormal_response_to0.56435185
154MP0001216_abnormal_epidermal_layer0.55881957
155MP0002102_abnormal_ear_morphology0.55748425

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)7.30220703
2Reticulocytopenia (HP:0001896)6.82411110
3Abnormal number of erythroid precursors (HP:0012131)6.60139467
4Macrocytic anemia (HP:0001972)4.93604012
5Pallor (HP:0000980)4.65107180
6Colon cancer (HP:0003003)4.29367406
7Increased hepatocellular lipid droplets (HP:0006565)3.87521529
8Birth length less than 3rd percentile (HP:0003561)3.74345233
9Aplastic anemia (HP:0001915)3.61030334
10Partial duplication of thumb phalanx (HP:0009944)3.59981172
11Thrombocytosis (HP:0001894)3.56904716
12Partial duplication of the phalanx of hand (HP:0009999)3.53920930
13Oral leukoplakia (HP:0002745)3.47802098
14Lipid accumulation in hepatocytes (HP:0006561)3.37364855
15Selective tooth agenesis (HP:0001592)3.24836865
1611 pairs of ribs (HP:0000878)3.04223552
17Abnormality of the parietal bone (HP:0002696)3.02822985
18Breast hypoplasia (HP:0003187)2.97772846
19Duplication of thumb phalanx (HP:0009942)2.91592979
20Trismus (HP:0000211)2.86171630
21Absent thumb (HP:0009777)2.83553792
22Acute necrotizing encephalopathy (HP:0006965)2.82410566
23Aplasia/Hypoplasia of the sacrum (HP:0008517)2.81451422
24Septo-optic dysplasia (HP:0100842)2.81314177
25Rough bone trabeculation (HP:0100670)2.76412877
26Mitochondrial inheritance (HP:0001427)2.66487553
27Multiple enchondromatosis (HP:0005701)2.65487777
28Carpal bone hypoplasia (HP:0001498)2.65475242
29Abnormal mitochondria in muscle tissue (HP:0008316)2.61680145
30Ependymoma (HP:0002888)2.60467608
31IgM deficiency (HP:0002850)2.57819525
32Medulloblastoma (HP:0002885)2.57020335
33Basal cell carcinoma (HP:0002671)2.56143995
34Degeneration of anterior horn cells (HP:0002398)2.53623778
35Abnormality of the anterior horn cell (HP:0006802)2.53623778
36Renal Fanconi syndrome (HP:0001994)2.53207127
37Respiratory difficulties (HP:0002880)2.51628592
38Abnormality of reticulocytes (HP:0004312)2.46061779
39Acute encephalopathy (HP:0006846)2.44577096
40Patellar aplasia (HP:0006443)2.43829815
41Microretrognathia (HP:0000308)2.43182090
42Neoplasm of the pancreas (HP:0002894)2.42840908
43Myelodysplasia (HP:0002863)2.41220101
44Increased intramyocellular lipid droplets (HP:0012240)2.40934138
45Abnormal number of incisors (HP:0011064)2.40183029
46Rib fusion (HP:0000902)2.33187060
47Aplasia/Hypoplasia of the patella (HP:0006498)2.31565193
48Asplenia (HP:0001746)2.28844117
49Stenosis of the external auditory canal (HP:0000402)2.28107555
50Increased CSF lactate (HP:0002490)2.27347295
51Glossoptosis (HP:0000162)2.26181795
52Agnosia (HP:0010524)2.25461683
53Premature graying of hair (HP:0002216)2.24961378
54Atresia of the external auditory canal (HP:0000413)2.23238644
55Missing ribs (HP:0000921)2.21547280
56Microvesicular hepatic steatosis (HP:0001414)2.19954215
57High anterior hairline (HP:0009890)2.19306782
58Abnormality of the preputium (HP:0100587)2.19032069
59Depressed nasal ridge (HP:0000457)2.15539568
60Amaurosis fugax (HP:0100576)2.15029621
61Esophageal atresia (HP:0002032)2.14647966
62Proximal placement of thumb (HP:0009623)2.13714810
63Cerebral hypomyelination (HP:0006808)2.10735384
64Aplasia/Hypoplasia of the spleen (HP:0010451)2.10092680
65Squamous cell carcinoma (HP:0002860)2.09100658
66Abnormal hemoglobin (HP:0011902)2.06887038
67Triphalangeal thumb (HP:0001199)2.05989624
68Chromsome breakage (HP:0040012)2.03469833
69Cellular immunodeficiency (HP:0005374)2.02845104
70Lymphoma (HP:0002665)2.02541698
71Hepatocellular necrosis (HP:0001404)2.01674917
72Absent septum pellucidum (HP:0001331)2.01305368
73Progressive macrocephaly (HP:0004481)2.00834973
74Deviation of the thumb (HP:0009603)2.00524964
75Meckel diverticulum (HP:0002245)1.98419743
76Abnormality of the phalanges of the hallux (HP:0010057)1.97624199
77Cerebral edema (HP:0002181)1.95571355
78Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.95100925
79Abnormality of chromosome stability (HP:0003220)1.95017058
80Thick lower lip vermilion (HP:0000179)1.94640944
81Poikiloderma (HP:0001029)1.94624107
82Absent radius (HP:0003974)1.93499844
83Hypoplasia of the radius (HP:0002984)1.92740240
84Abnormality of cochlea (HP:0000375)1.92558237
85Broad distal phalanx of finger (HP:0009836)1.91684692
86Abnormal trabecular bone morphology (HP:0100671)1.91527335
87Horseshoe kidney (HP:0000085)1.91506393
88Rhabdomyosarcoma (HP:0002859)1.90692491
89Maternal diabetes (HP:0009800)1.88894538
90Cleft eyelid (HP:0000625)1.88807554
91Tracheoesophageal fistula (HP:0002575)1.88784723
92Increased muscle lipid content (HP:0009058)1.88133699
93Abnormality of the 4th metacarpal (HP:0010012)1.88133498
94Abnormality of the septum pellucidum (HP:0007375)1.88058916
95Abnormality of the ileum (HP:0001549)1.88036995
96Decreased activity of mitochondrial respiratory chain (HP:0008972)1.85443050
97Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.85443050
98Bilateral microphthalmos (HP:0007633)1.85305312
99Exertional dyspnea (HP:0002875)1.83957500
100Bone marrow hypocellularity (HP:0005528)1.83295279
101Hepatic necrosis (HP:0002605)1.83164201
102Morphological abnormality of the inner ear (HP:0011390)1.82717556
103Premature ovarian failure (HP:0008209)1.81970623
104Pancytopenia (HP:0001876)1.80903614
105Neoplasm of the colon (HP:0100273)1.80858253
106Absent forearm bone (HP:0003953)1.76360370
107Aplasia involving forearm bones (HP:0009822)1.76360370
108Anophthalmia (HP:0000528)1.75733430
109Ectopic kidney (HP:0000086)1.75673399
110Secondary amenorrhea (HP:0000869)1.75015452
111Small intestinal stenosis (HP:0012848)1.73777745
112Duodenal stenosis (HP:0100867)1.73777745
113Irregular epiphyses (HP:0010582)1.72873505
114Congenital, generalized hypertrichosis (HP:0004540)1.72418068
115Abnormality of the phalanges of the 2nd finger (HP:0009541)1.71361658
116Midline defect of the nose (HP:0004122)1.70877536
117Chromosomal breakage induced by crosslinking agents (HP:0003221)1.69057093
118Nasolacrimal duct obstruction (HP:0000579)1.68054004
119Migraine (HP:0002076)1.67827135
120Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.67279195
121Entropion (HP:0000621)1.66361236
122Aplasia/Hypoplasia of the uvula (HP:0010293)1.65989625
123Slender long bone (HP:0003100)1.65330889
124Increased serum lactate (HP:0002151)1.65194031
125Optic nerve coloboma (HP:0000588)1.64756774
126Increased nuchal translucency (HP:0010880)1.64293771
127Overlapping toe (HP:0001845)1.64238819
128Sparse eyelashes (HP:0000653)1.63665416
129Abnormal lung lobation (HP:0002101)1.62483145
130Type I transferrin isoform profile (HP:0003642)1.61569885
131Forearm undergrowth (HP:0009821)1.60937914
132Acute lymphatic leukemia (HP:0006721)1.60807687
133Abnormality of renal resorption (HP:0011038)1.60024021
134Abnormality of the lacrimal duct (HP:0011481)1.59839811
135Abnormality of the umbilical cord (HP:0010881)1.59602493
136Abnormality of the calcaneus (HP:0008364)1.58952856
137Short nose (HP:0003196)1.58305251
1383-Methylglutaconic aciduria (HP:0003535)1.57788054
139Chronic otitis media (HP:0000389)1.57142461
140Aplasia/Hypoplasia of the thymus (HP:0010515)1.57118625
141Abnormality of T cell physiology (HP:0011840)1.56760935
142Supernumerary ribs (HP:0005815)1.56531711
143Abnormality of DNA repair (HP:0003254)1.56462593
144Leukodystrophy (HP:0002415)1.56381795
145Preauricular skin tag (HP:0000384)1.56143534
146Neoplasm of the oral cavity (HP:0100649)1.55788541
147Cerebellar dysplasia (HP:0007033)1.55309955
148Angiofibromas (HP:0010615)1.55123649
149Adenoma sebaceum (HP:0009720)1.55123649
150Lactic acidosis (HP:0003128)1.54943505
151Biliary tract neoplasm (HP:0100574)1.54807362
152Short thumb (HP:0009778)1.54775522
153Short 4th metacarpal (HP:0010044)1.54148567
154Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.54148567
155Facial cleft (HP:0002006)1.53461954
156Exercise intolerance (HP:0003546)1.53315421
157Abnormality of the nasolacrimal system (HP:0000614)1.52508611
158Vertebral hypoplasia (HP:0008417)1.52089061
159Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.52089061
160Concave nail (HP:0001598)1.51446762
161Hypoplasia of the pons (HP:0012110)1.49508295
162Abnormality of the diencephalon (HP:0010662)1.46609515
163Abnormality of the carotid arteries (HP:0005344)1.46046349
164Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.44789527
165Abnormality of the distal phalanx of the thumb (HP:0009617)1.44719191
166Coarctation of aorta (HP:0001680)1.44647938
167Supernumerary bones of the axial skeleton (HP:0009144)1.44267029

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.03313761
2BUB13.91940905
3NME23.58036709
4CDC73.32376601
5VRK23.29954644
6EEF2K2.80906718
7EIF2AK12.70686950
8RPS6KB22.53961181
9PASK2.42275422
10TSSK62.29090030
11TAF12.28711135
12SRPK12.23807461
13TGFBR12.22935158
14NEK22.22190555
15EPHB22.17005742
16STK162.12735514
17TESK21.88909702
18TLK11.86615206
19MKNK11.77733500
20EIF2AK31.77084726
21LRRK21.75585145
22DYRK31.75302722
23ACVR1B1.73068439
24VRK11.71749182
25MAP4K11.64814681
26BRSK21.64785534
27PBK1.63954137
28RPS6KA41.60052882
29FLT31.55974213
30CDK71.54925935
31AURKB1.54881442
32DYRK21.54828383
33TTK1.50332687
34MAP3K101.47628664
35PLK11.46507614
36PIM21.44956013
37SCYL21.41036247
38TYRO31.40711148
39PKN21.39144243
40ZAK1.37631200
41ATR1.35924805
42SMG11.30927240
43PAK41.30917459
44MAPKAPK31.28752832
45MAP3K81.26211941
46STK101.23578775
47NEK11.22818709
48CDK41.20481540
49EPHA21.18974591
50PLK41.10939246
51AURKA1.05387354
52KDR1.04463300
53MAP2K31.01167636
54MAPK150.98229631
55PIM10.97401266
56MKNK20.97122035
57PLK30.96926718
58MST40.96059320
59CHEK10.94140734
60BTK0.91429548
61DYRK1B0.90801544
62WNK40.88896734
63ZAP700.88125496
64CHEK20.84763606
65STK40.83040048
66CDK30.80832818
67CSNK2A20.80577548
68ILK0.80473954
69ICK0.79010951
70CDK190.75687396
71CDK120.74473450
72BRSK10.72977554
73TEC0.70031075
74LATS20.69948099
75NME10.68520828
76GRK60.66150237
77ALK0.65914726
78BRAF0.65682467
79PAK10.64213031
80TESK10.64111643
81CAMK1G0.63709643
82CSNK2A10.63563328
83CDK20.63270234
84CDK60.61817473
85ATM0.61573250
86RPS6KA50.61513949
87CDK11A0.61423560
88DAPK30.61326323
89STK240.60998261
90KIT0.59744677
91CAMK1D0.57546187
92PAK20.57139529
93PNCK0.57087127
94PIK3CA0.55280651
95DMPK0.54948963
96MAP3K110.54936184
97CSF1R0.53051271
98MAP3K40.53003546
99CDK80.52180459
100RPS6KA60.51691650
101PRKCI0.50120568
102RPS6KC10.50088156
103RPS6KL10.50088156
104BRD40.49947318
105MAP2K70.47191957
106JAK30.46228504
107BLK0.45937121
108FGFR10.44103894
109MAP2K40.43804570
110EIF2AK20.43701829
111MAP3K30.43633879
112CDK150.42490934
113NLK0.42040579
114CCNB10.39054255
115CDK10.37880657
116LATS10.36814324
117PRKDC0.36350825
118RPS6KA10.35213367
119AKT20.33451274
120NUAK10.33344063
121STK30.32824452
122MAP2K20.32675789
123MELK0.32341790
124LCK0.31809076
125CSNK1E0.31339109
126CDK140.31254485
127CDK180.31163207
128IKBKB0.31143958
129RPS6KB10.30226929
130AKT10.29806990
131MAPK140.29392209
132BCKDK0.29246462
133MTOR0.28323616
134SYK0.28302365
135MAP2K60.27722070
136CLK10.27686036
137LYN0.27576670
138PTK60.27367671
139MAPKAPK20.26880245
140FGFR20.26849626
141NTRK20.26384464
142LIMK10.26348542
143TRIB30.26235422

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030105.92727198
2DNA replication_Homo sapiens_hsa030304.63663510
3Mismatch repair_Homo sapiens_hsa034303.89298072
4Proteasome_Homo sapiens_hsa030503.37095683
5Spliceosome_Homo sapiens_hsa030403.36839296
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.20056868
7RNA polymerase_Homo sapiens_hsa030203.12440646
8RNA transport_Homo sapiens_hsa030132.86690828
9Base excision repair_Homo sapiens_hsa034102.75102470
10Nucleotide excision repair_Homo sapiens_hsa034202.72673031
11Homologous recombination_Homo sapiens_hsa034402.57469015
12Pyrimidine metabolism_Homo sapiens_hsa002402.39002600
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.30833901
14One carbon pool by folate_Homo sapiens_hsa006702.27433175
15Cell cycle_Homo sapiens_hsa041102.23108533
16Non-homologous end-joining_Homo sapiens_hsa034501.89282956
17Cardiac muscle contraction_Homo sapiens_hsa042601.79139035
18RNA degradation_Homo sapiens_hsa030181.72290219
19Fanconi anemia pathway_Homo sapiens_hsa034601.71942540
20Basal transcription factors_Homo sapiens_hsa030221.56242373
21mRNA surveillance pathway_Homo sapiens_hsa030151.48672427
22p53 signaling pathway_Homo sapiens_hsa041151.47815528
23Epstein-Barr virus infection_Homo sapiens_hsa051691.21772323
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21477017
25Protein export_Homo sapiens_hsa030601.18411776
26Antigen processing and presentation_Homo sapiens_hsa046121.17944317
27Purine metabolism_Homo sapiens_hsa002301.16001796
28Systemic lupus erythematosus_Homo sapiens_hsa053221.09788603
29Primary immunodeficiency_Homo sapiens_hsa053401.03585468
30Herpes simplex infection_Homo sapiens_hsa051680.97347326
31Viral carcinogenesis_Homo sapiens_hsa052030.90945030
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88953928
33Parkinsons disease_Homo sapiens_hsa050120.84240141
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82588066
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81867626
36Cyanoamino acid metabolism_Homo sapiens_hsa004600.81175329
37Sulfur relay system_Homo sapiens_hsa041220.81005643
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78659966
39Pentose phosphate pathway_Homo sapiens_hsa000300.77235356
40Huntingtons disease_Homo sapiens_hsa050160.77092630
41HTLV-I infection_Homo sapiens_hsa051660.74623067
42Thyroid cancer_Homo sapiens_hsa052160.72500452
43Pyruvate metabolism_Homo sapiens_hsa006200.72308930
44Folate biosynthesis_Homo sapiens_hsa007900.71313372
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69200952
46Small cell lung cancer_Homo sapiens_hsa052220.65616118
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63131095
48Legionellosis_Homo sapiens_hsa051340.62715385
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61859522
50Oxidative phosphorylation_Homo sapiens_hsa001900.60861494
51Wnt signaling pathway_Homo sapiens_hsa043100.60469697
52N-Glycan biosynthesis_Homo sapiens_hsa005100.58508241
53Oocyte meiosis_Homo sapiens_hsa041140.57278426
54Hematopoietic cell lineage_Homo sapiens_hsa046400.53946267
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.51990131
56Biosynthesis of amino acids_Homo sapiens_hsa012300.51646877
57Measles_Homo sapiens_hsa051620.50586522
58Shigellosis_Homo sapiens_hsa051310.50492782
59Apoptosis_Homo sapiens_hsa042100.49993292
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.48986625
61Glutathione metabolism_Homo sapiens_hsa004800.48653453
62MicroRNAs in cancer_Homo sapiens_hsa052060.48258296
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47701582
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47499080
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44897673
66Selenocompound metabolism_Homo sapiens_hsa004500.43821497
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.42144910
68Basal cell carcinoma_Homo sapiens_hsa052170.40940868
69Alcoholism_Homo sapiens_hsa050340.40867831
70Notch signaling pathway_Homo sapiens_hsa043300.40178278
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38778953
72Acute myeloid leukemia_Homo sapiens_hsa052210.38689992
73Chronic myeloid leukemia_Homo sapiens_hsa052200.38594447
74Colorectal cancer_Homo sapiens_hsa052100.37964094
75Hepatitis B_Homo sapiens_hsa051610.37541345
76Bladder cancer_Homo sapiens_hsa052190.36393984
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34686274
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.32873062
79TGF-beta signaling pathway_Homo sapiens_hsa043500.31497968
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31422721
81Pathways in cancer_Homo sapiens_hsa052000.31385025
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31102536
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30369031
84Propanoate metabolism_Homo sapiens_hsa006400.29996752
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29793488
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29779687
87Viral myocarditis_Homo sapiens_hsa054160.29426276
88HIF-1 signaling pathway_Homo sapiens_hsa040660.28848375
89Hippo signaling pathway_Homo sapiens_hsa043900.26576773
90Alzheimers disease_Homo sapiens_hsa050100.26002968
91Steroid biosynthesis_Homo sapiens_hsa001000.25938099
92Influenza A_Homo sapiens_hsa051640.23826865
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.23725713
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23517903
95B cell receptor signaling pathway_Homo sapiens_hsa046620.23376890
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.22967637
97Carbon metabolism_Homo sapiens_hsa012000.21945469
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.21704795
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21560045
100Asthma_Homo sapiens_hsa053100.21538344
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.21255346
102Melanoma_Homo sapiens_hsa052180.20105032
103T cell receptor signaling pathway_Homo sapiens_hsa046600.19447766
104Leishmaniasis_Homo sapiens_hsa051400.18952643
105Hedgehog signaling pathway_Homo sapiens_hsa043400.18622816
106Melanogenesis_Homo sapiens_hsa049160.17812676
107Renin-angiotensin system_Homo sapiens_hsa046140.17037414
108Allograft rejection_Homo sapiens_hsa053300.16907906
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.16717837
110Fatty acid elongation_Homo sapiens_hsa000620.16410617
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.15854628
1122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.15110044
113Axon guidance_Homo sapiens_hsa043600.14423072
114Galactose metabolism_Homo sapiens_hsa000520.14384961
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.14212125
116Metabolic pathways_Homo sapiens_hsa011000.14204155
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.13858693
118Toxoplasmosis_Homo sapiens_hsa051450.13386267
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.12854009
120Prostate cancer_Homo sapiens_hsa052150.12652551
121Renal cell carcinoma_Homo sapiens_hsa052110.10186019
122Arginine and proline metabolism_Homo sapiens_hsa003300.09599164
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.09297603
124Vitamin digestion and absorption_Homo sapiens_hsa049770.07622252
125Linoleic acid metabolism_Homo sapiens_hsa005910.06697906
126Tyrosine metabolism_Homo sapiens_hsa003500.02941287
127Lysine degradation_Homo sapiens_hsa003100.00674411
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.00317777
129Peroxisome_Homo sapiens_hsa04146-0.0224724
130Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280-0.0217459
131ErbB signaling pathway_Homo sapiens_hsa04012-0.0147527
132Maturity onset diabetes of the young_Homo sapiens_hsa04950-0.0139687

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