ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.84405575
2	protein neddylation (GO:0045116)	5.27610815
3	viral transcription (GO:0019083)	4.71531709
4	base-excision repair, AP site formation (GO:0006285)	4.53703488
5	translational termination (GO:0006415)	4.51589581
6	piRNA metabolic process (GO:0034587)	4.28252985
7	water-soluble vitamin biosynthetic process (GO:0042364)	4.21040147
8	ribonucleoprotein complex disassembly (GO:0032988)	4.12440069
9	rRNA catabolic process (GO:0016075)	4.07065772
10	organelle disassembly (GO:1903008)	3.95651705
11	ribosomal small subunit assembly (GO:0000028)	3.82943348
12	translational elongation (GO:0006414)	3.82091531
13	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.80678794
14	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.80678794
15	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.73929967
16	cell proliferation in forebrain (GO:0021846)	3.71866664
17	DNA methylation involved in gamete generation (GO:0043046)	3.71018817
18	adaptation of signaling pathway (GO:0023058)	3.70151771
19	cotranslational protein targeting to membrane (GO:0006613)	3.67899796
20	ATP synthesis coupled proton transport (GO:0015986)	3.66720081
21	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.66720081
22	protein targeting to ER (GO:0045047)	3.66272689
23	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.55396062
24	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.50843555
25	protein localization to endoplasmic reticulum (GO:0070972)	3.39214802
26	viral life cycle (GO:0019058)	3.37346316
27	maturation of SSU-rRNA (GO:0030490)	3.35885885
28	protein polyglutamylation (GO:0018095)	3.35368265
29	synaptic transmission, cholinergic (GO:0007271)	3.34562550
30	cellular biogenic amine catabolic process (GO:0042402)	3.31480740
31	amine catabolic process (GO:0009310)	3.31480740
32	translational initiation (GO:0006413)	3.25496549
33	cellular protein complex disassembly (GO:0043624)	3.24863600
34	DNA deamination (GO:0045006)	3.22273847
35	L-fucose metabolic process (GO:0042354)	3.18501664
36	L-fucose catabolic process (GO:0042355)	3.18501664
37	fucose catabolic process (GO:0019317)	3.18501664
38	intraciliary transport (GO:0042073)	3.13251436
39	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.11308264
40	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.09798880
41	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.08778080
42	kynurenine metabolic process (GO:0070189)	3.08745399
43	ubiquinone biosynthetic process (GO:0006744)	3.08173299
44	preassembly of GPI anchor in ER membrane (GO:0016254)	3.05378493
45	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	3.04099014
46	translation (GO:0006412)	3.02397843
47	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.01607980
48	DNA double-strand break processing (GO:0000729)	2.98983059
49	ncRNA catabolic process (GO:0034661)	2.98702747
50	indole-containing compound catabolic process (GO:0042436)	2.98043287
51	indolalkylamine catabolic process (GO:0046218)	2.98043287
52	tryptophan catabolic process (GO:0006569)	2.98043287
53	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.94791453
54	regulation of cilium movement (GO:0003352)	2.94579359
55	protein-cofactor linkage (GO:0018065)	2.92205935
56	pyrimidine nucleobase catabolic process (GO:0006208)	2.87649898
57	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.85263432
58	NADH dehydrogenase complex assembly (GO:0010257)	2.85263432
59	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.85263432
60	macromolecular complex disassembly (GO:0032984)	2.84949760
61	sulfation (GO:0051923)	2.84585188
62	purine deoxyribonucleotide catabolic process (GO:0009155)	2.81935831
63	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.81054464
64	chaperone-mediated protein transport (GO:0072321)	2.80125059
65	protein complex biogenesis (GO:0070271)	2.78811065
66	protein complex disassembly (GO:0043241)	2.75217676
67	cardiovascular system development (GO:0072358)	2.74900984
68	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.74758778
69	ribosomal large subunit biogenesis (GO:0042273)	2.73526629
70	regulation of cellular respiration (GO:0043457)	2.73337720
71	tRNA processing (GO:0008033)	2.72557442
72	ribosomal small subunit biogenesis (GO:0042274)	2.72268763
73	protein import into peroxisome matrix (GO:0016558)	2.70855790
74	deoxyribonucleotide catabolic process (GO:0009264)	2.67234233
75	cullin deneddylation (GO:0010388)	2.66258542
76	positive regulation of gastrulation (GO:2000543)	2.65550198
77	deoxyribose phosphate catabolic process (GO:0046386)	2.64829517
78	exogenous drug catabolic process (GO:0042738)	2.62815708
79	detection of light stimulus involved in visual perception (GO:0050908)	2.62705564
80	detection of light stimulus involved in sensory perception (GO:0050962)	2.62705564
81	pyrimidine nucleotide catabolic process (GO:0006244)	2.62303389
82	negative regulation of granulocyte differentiation (GO:0030853)	2.62012918
83	GTP biosynthetic process (GO:0006183)	2.61654869
84	respiratory chain complex IV assembly (GO:0008535)	2.61357001
85	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.60749975
86	inositol phosphate dephosphorylation (GO:0046855)	2.60749975
87	GPI anchor metabolic process (GO:0006505)	2.59805856
88	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.59001996
89	regulation of microtubule-based movement (GO:0060632)	2.57803387
90	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.57633020
91	negative regulation of systemic arterial blood pressure (GO:0003085)	2.57131538
92	ubiquinone metabolic process (GO:0006743)	2.56954509
93	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.54198073
94	neuron fate determination (GO:0048664)	2.53860099
95	mitochondrial respiratory chain complex assembly (GO:0033108)	2.52967955
96	oxidative demethylation (GO:0070989)	2.52412967
97	dopamine transport (GO:0015872)	2.51924699
98	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.49719909
99	negative regulation of mast cell activation (GO:0033004)	2.49222202
100	epithelial cilium movement (GO:0003351)	2.48409193

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	7.08872910
2	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.11120975
3	VDR_22108803_ChIP-Seq_LS180_Human	3.01199260
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.87927699
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.44725726
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.39569903
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.39534946
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.36913404
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.27402857
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.14519514
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.06515599
12	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.98487758
13	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.97460727
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.86536996
15	IGF1R_20145208_ChIP-Seq_DFB_Human	1.81978036
16	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.74600388
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.68363606
18	GBX2_23144817_ChIP-Seq_PC3_Human	1.68252564
19	ELK1_19687146_ChIP-ChIP_HELA_Human	1.67618945
20	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.67378819
21	REST_21632747_ChIP-Seq_MESCs_Mouse	1.64569082
22	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.61252857
23	TP53_22573176_ChIP-Seq_HFKS_Human	1.60474242
24	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.57088036
25	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.54804685
26	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.46492413
27	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.44330527
28	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.41509797
29	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.41411008
30	RNF2_27304074_Chip-Seq_NSC_Mouse	1.40455072
31	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.38889884
32	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.38445866
33	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.37685095
34	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.37640683
35	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.37332880
36	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.35044629
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.34930069
38	VDR_23849224_ChIP-Seq_CD4+_Human	1.34739214
39	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.33472438
40	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.32771474
41	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.32606908
42	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.31970386
43	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.29520599
44	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.27697727
45	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.25831977
46	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.25108590
47	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.23094165
48	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.22211465
49	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.20293421
50	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.18824105
51	EWS_26573619_Chip-Seq_HEK293_Human	1.17548577
52	TAF2_19829295_ChIP-Seq_ESCs_Human	1.17461706
53	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.16896035
54	NCOR_22424771_ChIP-Seq_293T_Human	1.16622926
55	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16125570
56	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.15172617
57	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.14331005
58	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.12971575
59	FOXP3_21729870_ChIP-Seq_TREG_Human	1.11847830
60	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.11236793
61	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.10581888
62	FUS_26573619_Chip-Seq_HEK293_Human	1.09653784
63	NANOG_20526341_ChIP-Seq_ESCs_Human	1.08376237
64	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.07998021
65	ERA_21632823_ChIP-Seq_H3396_Human	1.07459923
66	MYC_18940864_ChIP-ChIP_HL60_Human	1.06526615
67	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.06443992
68	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.06443992
69	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.05091337
70	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.00345455
71	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.99450990
72	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.98811245
73	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.98126555
74	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.97304047
75	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.96914376
76	P53_21459846_ChIP-Seq_SAOS-2_Human	0.96601934
77	TCF4_22108803_ChIP-Seq_LS180_Human	0.95592883
78	HOXB7_26014856_ChIP-Seq_BT474_Human	0.95430688
79	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.94976875
80	IRF1_19129219_ChIP-ChIP_H3396_Human	0.94778961
81	AR_20517297_ChIP-Seq_VCAP_Human	0.94314470
82	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.94177160
83	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.93501517
84	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.93377912
85	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.93144684
86	P300_19829295_ChIP-Seq_ESCs_Human	0.93021218
87	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.92240543
88	CBP_20019798_ChIP-Seq_JUKART_Human	0.92240543
89	RAC3_21632823_ChIP-Seq_H3396_Human	0.91190765
90	NANOG_19829295_ChIP-Seq_ESCs_Human	0.90991642
91	SOX2_19829295_ChIP-Seq_ESCs_Human	0.90991642
92	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.90059599
93	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.90059599
94	MYC_19829295_ChIP-Seq_ESCs_Human	0.89262656
95	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.88251097
96	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.87763101
97	OCT4_20526341_ChIP-Seq_ESCs_Human	0.86146536
98	CIITA_25753668_ChIP-Seq_RAJI_Human	0.85305624
99	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.85163135
100	TAF15_26573619_Chip-Seq_HEK293_Human	0.84233164

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.44303812
2	MP0004147_increased_porphyrin_level	3.25031672
3	MP0008789_abnormal_olfactory_epithelium	2.66032677
4	MP0002876_abnormal_thyroid_physiology	2.58968326
5	MP0003646_muscle_fatigue	2.50019972
6	MP0009379_abnormal_foot_pigmentation	2.47344772
7	MP0005084_abnormal_gallbladder_morpholo	2.25527327
8	MP0001968_abnormal_touch/_nociception	2.20720736
9	MP0005167_abnormal_blood-brain_barrier	2.20298581
10	MP0008877_abnormal_DNA_methylation	2.18561169
11	MP0004142_abnormal_muscle_tone	2.18085253
12	MP0001986_abnormal_taste_sensitivity	2.17707929
13	MP0008872_abnormal_physiological_respon	2.14691813
14	MP0004885_abnormal_endolymph	2.10617330
15	MP0008875_abnormal_xenobiotic_pharmacok	2.01869478
16	MP0001440_abnormal_grooming_behavior	2.00343177
17	MP0003879_abnormal_hair_cell	1.97718494
18	MP0005394_taste/olfaction_phenotype	1.94794509
19	MP0005499_abnormal_olfactory_system	1.94794509
20	MP0002163_abnormal_gland_morphology	1.91022283
21	MP0002837_dystrophic_cardiac_calcinosis	1.90778555
22	MP0005423_abnormal_somatic_nervous	1.79132900
23	MP0002234_abnormal_pharynx_morphology	1.76790397
24	MP0002138_abnormal_hepatobiliary_system	1.74876217
25	MP0002736_abnormal_nociception_after	1.71210301
26	MP0006072_abnormal_retinal_apoptosis	1.68941786
27	MP0002272_abnormal_nervous_system	1.66371197
28	MP0004858_abnormal_nervous_system	1.65320928
29	MP0006276_abnormal_autonomic_nervous	1.64194211
30	MP0008775_abnormal_heart_ventricle	1.63506765
31	MP0005551_abnormal_eye_electrophysiolog	1.61818718
32	MP0002160_abnormal_reproductive_system	1.59519675
33	MP0001542_abnormal_bone_strength	1.57822932
34	MP0001485_abnormal_pinna_reflex	1.57775869
35	MP0005389_reproductive_system_phenotype	1.56535938
36	MP0002102_abnormal_ear_morphology	1.56018993
37	MP0003123_paternal_imprinting	1.54943610
38	MP0002735_abnormal_chemical_nociception	1.44406770
39	MP0005645_abnormal_hypothalamus_physiol	1.44324036
40	MP0009745_abnormal_behavioral_response	1.43807492
41	MP0000778_abnormal_nervous_system	1.43428815
42	MP0002733_abnormal_thermal_nociception	1.41844695
43	MP0001970_abnormal_pain_threshold	1.41382975
44	MP0003787_abnormal_imprinting	1.38169063
45	MP0001835_abnormal_antigen_presentation	1.37626154
46	MP0001293_anophthalmia	1.36924915
47	MP0010386_abnormal_urinary_bladder	1.36438555
48	MP0002928_abnormal_bile_duct	1.35792748
49	MP0001188_hyperpigmentation	1.32150681
50	MP0004145_abnormal_muscle_electrophysio	1.28080788
51	MP0000372_irregular_coat_pigmentation	1.25104539
52	MP0002572_abnormal_emotion/affect_behav	1.23817596
53	MP0002184_abnormal_innervation	1.23019506
54	MP0000427_abnormal_hair_cycle	1.19771242
55	MP0003880_abnormal_central_pattern	1.19639172
56	MP0001919_abnormal_reproductive_system	1.19143787
57	MP0001486_abnormal_startle_reflex	1.17873734
58	MP0000631_abnormal_neuroendocrine_gland	1.15616144
59	MP0005410_abnormal_fertilization	1.15553041
60	MP0005075_abnormal_melanosome_morpholog	1.13871665
61	MP0009046_muscle_twitch	1.12788187
62	MP0002063_abnormal_learning/memory/cond	1.08925866
63	MP0004133_heterotaxia	1.07709021
64	MP0003121_genomic_imprinting	1.06833897
65	MP0000685_abnormal_immune_system	1.06792638
66	MP0005671_abnormal_response_to	1.05848306
67	MP0003635_abnormal_synaptic_transmissio	1.04931741
68	MP0002557_abnormal_social/conspecific_i	1.04599863
69	MP0005195_abnormal_posterior_eye	1.04597505
70	MP0000569_abnormal_digit_pigmentation	1.04492049
71	MP0003724_increased_susceptibility_to	1.03902144
72	MP0005253_abnormal_eye_physiology	1.03850951
73	MP0003122_maternal_imprinting	0.99729331
74	MP0009764_decreased_sensitivity_to	0.99408422
75	MP0002064_seizures	0.97762911
76	MP0003252_abnormal_bile_duct	0.96791503
77	MP0003878_abnormal_ear_physiology	0.93847264
78	MP0005377_hearing/vestibular/ear_phenot	0.93847264
79	MP0001905_abnormal_dopamine_level	0.93707510
80	MP0009697_abnormal_copulation	0.93401091
81	MP0005379_endocrine/exocrine_gland_phen	0.93266610
82	MP0005503_abnormal_tendon_morphology	0.93067632
83	MP0003195_calcinosis	0.90780934
84	MP0002752_abnormal_somatic_nervous	0.86069810
85	MP0001756_abnormal_urination	0.84379898
86	MP0001501_abnormal_sleep_pattern	0.81864477
87	MP0005083_abnormal_biliary_tract	0.80949568
88	MP0005174_abnormal_tail_pigmentation	0.80947475
89	MP0003806_abnormal_nucleotide_metabolis	0.80568074
90	MP0003137_abnormal_impulse_conducting	0.79211686
91	MP0001529_abnormal_vocalization	0.79047835
92	MP0005646_abnormal_pituitary_gland	0.78343061
93	MP0000230_abnormal_systemic_arterial	0.77580742
94	MP0001963_abnormal_hearing_physiology	0.75929238
95	MP0004130_abnormal_muscle_cell	0.75824775
96	MP0000613_abnormal_salivary_gland	0.74571003
97	MP0000026_abnormal_inner_ear	0.74443778
98	MP0005386_behavior/neurological_phenoty	0.73357516
99	MP0004924_abnormal_behavior	0.73357516
100	MP0003011_delayed_dark_adaptation	0.72676642

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Agitation (HP:0000713)	3.90397538
2	Pancreatic cysts (HP:0001737)	3.56800374
3	Hyperglycinemia (HP:0002154)	3.52378529
4	Pancreatic fibrosis (HP:0100732)	3.50635937
5	True hermaphroditism (HP:0010459)	3.39380066
6	Chronic hepatic failure (HP:0100626)	3.39134527
7	Type II lissencephaly (HP:0007260)	3.37058993
8	Decreased central vision (HP:0007663)	3.24335380
9	Abnormality of midbrain morphology (HP:0002418)	3.22288542
10	Molar tooth sign on MRI (HP:0002419)	3.22288542
11	Lipid accumulation in hepatocytes (HP:0006561)	3.15614109
12	Increased hepatocellular lipid droplets (HP:0006565)	3.03185695
13	Thyroid-stimulating hormone excess (HP:0002925)	2.94865998
14	Hypoplasia of the uterus (HP:0000013)	2.88584678
15	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.86309257
16	Abnormality of the pons (HP:0007361)	2.84105225
17	Large for gestational age (HP:0001520)	2.82764888
18	Genetic anticipation (HP:0003743)	2.79625920
19	Abnormality of cells of the erythroid lineage (HP:0012130)	2.78763985
20	Medial flaring of the eyebrow (HP:0010747)	2.78653039
21	Abnormality of the renal collecting system (HP:0004742)	2.75982417
22	Nephronophthisis (HP:0000090)	2.75540723
23	Broad-based gait (HP:0002136)	2.74872667
24	Abnormal rod and cone electroretinograms (HP:0008323)	2.71257504
25	Aplasia/hypoplasia of the uterus (HP:0008684)	2.68627657
26	Stomatitis (HP:0010280)	2.68052602
27	Duplicated collecting system (HP:0000081)	2.66264533
28	Increased CSF lactate (HP:0002490)	2.66074661
29	Increased corneal curvature (HP:0100692)	2.65235409
30	Keratoconus (HP:0000563)	2.65235409
31	Mitochondrial inheritance (HP:0001427)	2.63923044
32	Absent/shortened dynein arms (HP:0200106)	2.56173762
33	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.56173762
34	Pendular nystagmus (HP:0012043)	2.55225479
35	3-Methylglutaconic aciduria (HP:0003535)	2.51347997
36	Cerebellar dysplasia (HP:0007033)	2.50718974
37	Congenital, generalized hypertrichosis (HP:0004540)	2.49507749
38	Abnormality of the corticospinal tract (HP:0002492)	2.42719406
39	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.41758862
40	Abnormal number of erythroid precursors (HP:0012131)	2.41275601
41	Cystic liver disease (HP:0006706)	2.40514719
42	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.38087392
43	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.38087392
44	Acute encephalopathy (HP:0006846)	2.37652322
45	Reticulocytopenia (HP:0001896)	2.34776132
46	Myokymia (HP:0002411)	2.33776179
47	Methylmalonic aciduria (HP:0012120)	2.29641822
48	Acute necrotizing encephalopathy (HP:0006965)	2.29401920
49	Macrocytic anemia (HP:0001972)	2.28826629
50	Supernumerary spleens (HP:0009799)	2.28652623
51	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.28563892
52	Congenital stationary night blindness (HP:0007642)	2.24472213
53	Hepatocellular necrosis (HP:0001404)	2.22577621
54	Abnormality of glycine metabolism (HP:0010895)	2.22413027
55	Abnormality of serine family amino acid metabolism (HP:0010894)	2.22413027
56	Hyperglycinuria (HP:0003108)	2.22399604
57	Exertional dyspnea (HP:0002875)	2.21212910
58	Attenuation of retinal blood vessels (HP:0007843)	2.21153187
59	Restlessness (HP:0000711)	2.20859775
60	Absent septum pellucidum (HP:0001331)	2.18898396
61	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.18787721
62	Abolished electroretinogram (ERG) (HP:0000550)	2.17671491
63	Bony spicule pigmentary retinopathy (HP:0007737)	2.17431745
64	Asplenia (HP:0001746)	2.17117405
65	Increased IgM level (HP:0003496)	2.16893824
66	Sclerocornea (HP:0000647)	2.16116988
67	Tachypnea (HP:0002789)	2.16069861
68	Methylmalonic acidemia (HP:0002912)	2.15694750
69	Poor head control (HP:0002421)	2.15062825
70	Anencephaly (HP:0002323)	2.14413294
71	Renal Fanconi syndrome (HP:0001994)	2.13405575
72	Male pseudohermaphroditism (HP:0000037)	2.06393897
73	Abnormality of the renal medulla (HP:0100957)	2.05132053
74	Absent thumb (HP:0009777)	2.03682441
75	Gait imbalance (HP:0002141)	2.01593138
76	Hepatic necrosis (HP:0002605)	2.01289313
77	Abnormality of renal resorption (HP:0011038)	1.99378172
78	Polyphagia (HP:0002591)	1.98048919
79	Dyskinesia (HP:0100660)	1.95616532
80	Abnormal respiratory epithelium morphology (HP:0012253)	1.92798838
81	Abnormal respiratory motile cilium morphology (HP:0005938)	1.92798838
82	Abnormal mitochondria in muscle tissue (HP:0008316)	1.92570769
83	Pachygyria (HP:0001302)	1.91198422
84	Congenital primary aphakia (HP:0007707)	1.89513584
85	Congenital hepatic fibrosis (HP:0002612)	1.89495084
86	Limb dystonia (HP:0002451)	1.88512621
87	Hypoplasia of the pons (HP:0012110)	1.88361620
88	Progressive macrocephaly (HP:0004481)	1.87689466
89	Febrile seizures (HP:0002373)	1.87636707
90	IgG deficiency (HP:0004315)	1.86820179
91	Increased serum lactate (HP:0002151)	1.85238759
92	Abnormality of the renal cortex (HP:0011035)	1.85030119
93	Severe muscular hypotonia (HP:0006829)	1.84911888
94	Abnormality of lateral ventricle (HP:0030047)	1.84599784
95	Abnormal drinking behavior (HP:0030082)	1.84553840
96	Polydipsia (HP:0001959)	1.84553840
97	Epileptic encephalopathy (HP:0200134)	1.84478366
98	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.83642683
99	Dicarboxylic aciduria (HP:0003215)	1.83642683
100	Postaxial foot polydactyly (HP:0001830)	1.83541837

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TIE1	6.30208319
2	FRK	3.61410351
3	ACVR1B	3.32978804
4	WNK4	2.94850188
5	GRK1	2.75946288
6	STK39	2.59971882
7	CDK19	2.48415768
8	TLK1	2.31833069
9	OXSR1	2.20009446
10	BMPR1B	2.07876102
11	PINK1	2.02877308
12	NUAK1	1.97696266
13	TEC	1.93516328
14	MUSK	1.90352725
15	WNK1	1.89320380
16	ADRBK2	1.79833546
17	MAP3K4	1.61692133
18	TAOK3	1.53515643
19	BCKDK	1.51556801
20	PHKG2	1.43818206
21	PHKG1	1.43818206
22	MAPKAPK3	1.41390724
23	PIK3CA	1.28202027
24	MKNK2	1.19408688
25	CASK	1.15724185
26	TNIK	1.14837484
27	TGFBR1	1.14718313
28	MAP4K2	1.10978469
29	ZAK	1.06844184
30	MARK1	1.05310110
31	MAPK13	1.03384208
32	MAP2K7	1.02650691
33	DYRK2	1.02487053
34	FES	1.00410786
35	DAPK2	0.99390430
36	STK16	0.97395170
37	PRKCH	0.95164960
38	CSNK1G3	0.94541079
39	KIT	0.92602489
40	NEK1	0.92086204
41	EPHA4	0.91640905
42	AKT3	0.90914756
43	CSNK1G2	0.87432134
44	CAMK1	0.84488426
45	EPHB2	0.83994641
46	PRKCG	0.80531668
47	INSRR	0.74608000
48	MINK1	0.74289399
49	RPS6KA5	0.73282184
50	EIF2AK3	0.71774979
51	CHUK	0.71745395
52	TXK	0.70692731
53	ERBB3	0.70674748
54	ADRBK1	0.70102421
55	PRKCQ	0.67976770
56	RPS6KA6	0.67859286
57	CAMKK1	0.66475391
58	ITK	0.66122455
59	CSNK1G1	0.65404614
60	CSNK1A1L	0.65109341
61	ICK	0.64236733
62	KDR	0.63605056
63	CDC7	0.61912254
64	GRK5	0.61204513
65	BTK	0.60887977
66	TYRO3	0.60197134
67	MKNK1	0.59845313
68	TNK2	0.55320894
69	PRKACA	0.53813254
70	BMPR2	0.51894279
71	MARK3	0.51656309
72	IKBKB	0.51509928
73	PRKCZ	0.50064997
74	CSNK1A1	0.49112256
75	MAPK15	0.46647994
76	PRKCA	0.46089804
77	RPS6KL1	0.44863152
78	RPS6KC1	0.44863152
79	IKBKE	0.44822710
80	ABL2	0.44606824
81	EIF2AK2	0.42961587
82	MAP2K2	0.42783447
83	PRKCD	0.42585313
84	PRKCE	0.42291267
85	SYK	0.41013467
86	STK11	0.40878502
87	TRIM28	0.40188081
88	VRK2	0.39529583
89	GRK7	0.39354335
90	MAPKAPK5	0.36375226
91	CSNK2A2	0.36056140
92	CSF1R	0.35966083
93	ABL1	0.35206604
94	CSNK1D	0.33777259
95	FGFR2	0.33774289
96	OBSCN	0.32825758
97	PRKACG	0.32660040
98	CAMKK2	0.31789035
99	VRK1	0.31245308
100	MAP2K4	0.31020588

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.05634921
2	Asthma_Homo sapiens_hsa05310	3.34256780
3	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.28082660
4	Oxidative phosphorylation_Homo sapiens_hsa00190	3.07467047
5	Phototransduction_Homo sapiens_hsa04744	2.99712838
6	Parkinsons disease_Homo sapiens_hsa05012	2.39228215
7	Sulfur relay system_Homo sapiens_hsa04122	2.35460791
8	RNA polymerase_Homo sapiens_hsa03020	2.15976063
9	Allograft rejection_Homo sapiens_hsa05330	2.14227261
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.10463159
11	Cardiac muscle contraction_Homo sapiens_hsa04260	2.09728187
12	Proteasome_Homo sapiens_hsa03050	2.03275635
13	Caffeine metabolism_Homo sapiens_hsa00232	2.02755926
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.98548374
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.90919307
16	Graft-versus-host disease_Homo sapiens_hsa05332	1.89896443
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.80436668
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.78917604
19	Alzheimers disease_Homo sapiens_hsa05010	1.72270708
20	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.63361186
21	Protein export_Homo sapiens_hsa03060	1.61273974
22	One carbon pool by folate_Homo sapiens_hsa00670	1.60170718
23	Huntingtons disease_Homo sapiens_hsa05016	1.56950078
24	Nicotine addiction_Homo sapiens_hsa05033	1.50134631
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.49038795
26	Rheumatoid arthritis_Homo sapiens_hsa05323	1.48249446
27	Selenocompound metabolism_Homo sapiens_hsa00450	1.44981026
28	Sulfur metabolism_Homo sapiens_hsa00920	1.44807239
29	Propanoate metabolism_Homo sapiens_hsa00640	1.43021710
30	RNA degradation_Homo sapiens_hsa03018	1.41915123
31	Basal transcription factors_Homo sapiens_hsa03022	1.41713778
32	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.40484252
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.39370181
34	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.30246669
35	Type I diabetes mellitus_Homo sapiens_hsa04940	1.21707729
36	Collecting duct acid secretion_Homo sapiens_hsa04966	1.13007096
37	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.11743220
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.02874568
39	Butanoate metabolism_Homo sapiens_hsa00650	1.02702022
40	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.01898592
41	Tryptophan metabolism_Homo sapiens_hsa00380	0.98735134
42	Peroxisome_Homo sapiens_hsa04146	0.95362790
43	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.94294781
44	Pyrimidine metabolism_Homo sapiens_hsa00240	0.93411688
45	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.89594651
46	Morphine addiction_Homo sapiens_hsa05032	0.87590270
47	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.86611966
48	Nitrogen metabolism_Homo sapiens_hsa00910	0.85530161
49	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.83781524
50	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.82177905
51	Fat digestion and absorption_Homo sapiens_hsa04975	0.81585732
52	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.80416838
53	Ether lipid metabolism_Homo sapiens_hsa00565	0.77904703
54	Salivary secretion_Homo sapiens_hsa04970	0.76884151
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.71306676
56	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.70941695
57	Olfactory transduction_Homo sapiens_hsa04740	0.69861227
58	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.69529536
59	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.69230185
60	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.67468582
61	Purine metabolism_Homo sapiens_hsa00230	0.66754256
62	Insulin secretion_Homo sapiens_hsa04911	0.66553788
63	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.65520921
64	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.60691435
65	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.59081712
66	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.57304984
67	Metabolic pathways_Homo sapiens_hsa01100	0.56451019
68	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.53716370
69	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.53704207
70	Retinol metabolism_Homo sapiens_hsa00830	0.52411715
71	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.52004395
72	Arginine and proline metabolism_Homo sapiens_hsa00330	0.51461308
73	Glutamatergic synapse_Homo sapiens_hsa04724	0.49828606
74	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.49710360
75	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.48710157
76	Serotonergic synapse_Homo sapiens_hsa04726	0.48581805
77	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.47136426
78	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.46947790
79	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.45274996
80	Regulation of autophagy_Homo sapiens_hsa04140	0.45096355
81	Viral myocarditis_Homo sapiens_hsa05416	0.44605369
82	Antigen processing and presentation_Homo sapiens_hsa04612	0.44528996
83	Taste transduction_Homo sapiens_hsa04742	0.44457695
84	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.43566827
85	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.42838400
86	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.40757416
87	Pancreatic secretion_Homo sapiens_hsa04972	0.40323988
88	Glycerolipid metabolism_Homo sapiens_hsa00561	0.39369770
89	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.38486137
90	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.38260496
91	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.37183418
92	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.36356620
93	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.35151650
94	Calcium signaling pathway_Homo sapiens_hsa04020	0.31592151
95	Homologous recombination_Homo sapiens_hsa03440	0.30728415
96	Fatty acid degradation_Homo sapiens_hsa00071	0.30590991
97	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.28760286
98	Circadian entrainment_Homo sapiens_hsa04713	0.28619533
99	GABAergic synapse_Homo sapiens_hsa04727	0.28582985
100	RNA transport_Homo sapiens_hsa03013	0.28224680

RPL6P12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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