RPL6P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)9.86640786
2translational termination (GO:0006415)9.44527405
3SRP-dependent cotranslational protein targeting to membrane (GO:0006614)8.00952789
4cotranslational protein targeting to membrane (GO:0006613)7.97497138
5protein targeting to ER (GO:0045047)7.86881620
6translational elongation (GO:0006414)7.80151976
7ribosomal small subunit assembly (GO:0000028)7.74985934
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.66370239
9establishment of protein localization to endoplasmic reticulum (GO:0072599)7.52691699
10ribosomal small subunit biogenesis (GO:0042274)7.37951474
11protein localization to endoplasmic reticulum (GO:0070972)7.31706362
12cellular protein complex disassembly (GO:0043624)7.22341198
13energy coupled proton transport, down electrochemical gradient (GO:0015985)7.18748903
14ATP synthesis coupled proton transport (GO:0015986)7.18748903
15maturation of SSU-rRNA (GO:0030490)7.15346581
16viral life cycle (GO:0019058)7.12002386
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.90080590
18translational initiation (GO:0006413)6.19706645
19protein complex disassembly (GO:0043241)6.13921496
20macromolecular complex disassembly (GO:0032984)5.77030468
21establishment of protein localization to mitochondrial membrane (GO:0090151)5.50404275
22protein targeting to membrane (GO:0006612)5.25764164
23protein neddylation (GO:0045116)5.24396433
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.06367473
25chaperone-mediated protein transport (GO:0072321)5.05781990
26ribosomal large subunit biogenesis (GO:0042273)4.97517499
27respiratory electron transport chain (GO:0022904)4.88302880
28electron transport chain (GO:0022900)4.86860662
29nuclear-transcribed mRNA catabolic process (GO:0000956)4.77347568
30behavioral response to nicotine (GO:0035095)4.65319836
31mRNA catabolic process (GO:0006402)4.55031263
32translation (GO:0006412)4.50458290
33protein complex biogenesis (GO:0070271)4.29377282
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.20256052
35mitochondrial respiratory chain complex I assembly (GO:0032981)4.20256052
36NADH dehydrogenase complex assembly (GO:0010257)4.20256052
37RNA catabolic process (GO:0006401)4.04067897
38mitochondrial respiratory chain complex assembly (GO:0033108)3.98329140
39ATP biosynthetic process (GO:0006754)3.96464388
40sequestering of actin monomers (GO:0042989)3.73157240
41hydrogen ion transmembrane transport (GO:1902600)3.65558102
42purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.60574215
43establishment of protein localization to membrane (GO:0090150)3.56661433
44purine nucleoside triphosphate biosynthetic process (GO:0009145)3.53624112
45inner mitochondrial membrane organization (GO:0007007)3.42559806
46protein targeting (GO:0006605)3.31075052
47proton transport (GO:0015992)3.28907191
48hydrogen transport (GO:0006818)3.25695939
49cellular component biogenesis (GO:0044085)3.25438691
50positive regulation of prostaglandin secretion (GO:0032308)3.21461126
51ribonucleoprotein complex biogenesis (GO:0022613)3.20492075
52establishment of protein localization to organelle (GO:0072594)3.20315931
53ribonucleoside triphosphate biosynthetic process (GO:0009201)3.05478634
54epithelial cilium movement (GO:0003351)3.03069075
55epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.01834805
56transcription elongation from RNA polymerase III promoter (GO:0006385)2.96537557
57termination of RNA polymerase III transcription (GO:0006386)2.96537557
58neuron fate determination (GO:0048664)2.89897371
59detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.86510892
60protein localization to membrane (GO:0072657)2.83808394
61protein-cofactor linkage (GO:0018065)2.79770923
62negative regulation of transcription regulatory region DNA binding (GO:2000678)2.78252120
63spliceosomal complex assembly (GO:0000245)2.77230968
64regulation of mitochondrial translation (GO:0070129)2.77020665
65midbrain development (GO:0030901)2.76860606
66somite development (GO:0061053)2.74891784
67synaptic transmission, cholinergic (GO:0007271)2.73337085
68positive regulation of gastrulation (GO:2000543)2.68469283
69intracellular protein transmembrane import (GO:0044743)2.66250890
70nucleoside triphosphate biosynthetic process (GO:0009142)2.65455605
71regulation of prostaglandin secretion (GO:0032306)2.62776474
72thalamus development (GO:0021794)2.62337751
73cell proliferation in forebrain (GO:0021846)2.62025975
74nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.55156057
75tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.54014357
76RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.54014357
77spinal cord association neuron differentiation (GO:0021527)2.53686202
78DNA damage response, detection of DNA damage (GO:0042769)2.53500440
79nonmotile primary cilium assembly (GO:0035058)2.52898013
80rRNA processing (GO:0006364)2.52821082
81kidney morphogenesis (GO:0060993)2.49968790
82GTP biosynthetic process (GO:0006183)2.46922002
83retinal ganglion cell axon guidance (GO:0031290)2.46113423
84rRNA metabolic process (GO:0016072)2.45903121
85inner ear receptor cell development (GO:0060119)2.43771569
86cilium movement (GO:0003341)2.43295444
87protein localization to organelle (GO:0033365)2.41680583
88positive regulation of fatty acid transport (GO:2000193)2.41063037
89exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.40707943
90water-soluble vitamin biosynthetic process (GO:0042364)2.39816737
91spinal cord development (GO:0021510)2.36631768
92otic vesicle formation (GO:0030916)2.36048830
93chromatin remodeling at centromere (GO:0031055)2.36015602
94platelet dense granule organization (GO:0060155)2.34885972
95positive regulation of icosanoid secretion (GO:0032305)2.34363034
96cell differentiation in spinal cord (GO:0021515)2.34116539
97anterograde axon cargo transport (GO:0008089)2.30814658
98pyrimidine nucleobase catabolic process (GO:0006208)2.30114053
99establishment of protein localization to mitochondrion (GO:0072655)2.26383885
100spinal cord motor neuron differentiation (GO:0021522)2.25018466

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.96005892
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.46499442
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.27042092
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.08839313
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.79664995
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.63358275
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.59109246
8VDR_22108803_ChIP-Seq_LS180_Human2.45599299
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.39487925
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.37502789
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.18487271
12ZNF274_21170338_ChIP-Seq_K562_Hela2.16326899
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14408423
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.06547937
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.03263916
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.02343169
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.98392881
18MYC_18940864_ChIP-ChIP_HL60_Human1.95068275
19TP63_19390658_ChIP-ChIP_HaCaT_Human1.87838581
20ETS1_20019798_ChIP-Seq_JURKAT_Human1.86852611
21ELK1_19687146_ChIP-ChIP_HELA_Human1.85108835
22FUS_26573619_Chip-Seq_HEK293_Human1.81564444
23POU5F1_16153702_ChIP-ChIP_HESCs_Human1.81109068
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.80186416
25EWS_26573619_Chip-Seq_HEK293_Human1.78412519
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.77331360
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.72884408
28TTF2_22483619_ChIP-Seq_HELA_Human1.69215239
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.68176749
30RNF2_27304074_Chip-Seq_NSC_Mouse1.64258398
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63396360
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63378182
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60199534
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.54118626
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.51390720
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.48660044
37REST_21632747_ChIP-Seq_MESCs_Mouse1.48026846
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.45493692
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.44897424
40POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43245425
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41686236
42XRN2_22483619_ChIP-Seq_HELA_Human1.41221531
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40209169
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40094888
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38941993
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38610180
47SOX2_16153702_ChIP-ChIP_HESCs_Human1.38193871
48TP53_22573176_ChIP-Seq_HFKS_Human1.35865166
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.35729662
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35555955
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31376844
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31376844
53P300_19829295_ChIP-Seq_ESCs_Human1.29569405
54VDR_23849224_ChIP-Seq_CD4+_Human1.28419738
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26144324
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23549531
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.21827512
58RNF2_27304074_Chip-Seq_ESCs_Mouse1.21556216
59SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.20017076
60ETV2_25802403_ChIP-Seq_MESCs_Mouse1.17621580
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16600879
62CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16317701
63TP53_20018659_ChIP-ChIP_R1E_Mouse1.16294013
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.15238979
65CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.14959649
66KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14687483
67TAF15_26573619_Chip-Seq_HEK293_Human1.14215387
68IGF1R_20145208_ChIP-Seq_DFB_Human1.13813053
69FOXP3_21729870_ChIP-Seq_TREG_Human1.11263840
70RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09835725
71EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09835725
72SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09679891
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09677725
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07387918
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06027104
76GBX2_23144817_ChIP-Seq_PC3_Human1.05970946
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02405274
78SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01478693
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01424393
80ELK1_22589737_ChIP-Seq_MCF10A_Human1.00581262
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00170634
82SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99982426
83ER_23166858_ChIP-Seq_MCF-7_Human0.99316359
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99104820
85SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.97898913
86REST_18959480_ChIP-ChIP_MESCs_Mouse0.97194425
87FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96595738
88E2F4_17652178_ChIP-ChIP_JURKAT_Human0.96319031
89RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95940264
90AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94506416
91AR_21572438_ChIP-Seq_LNCaP_Human0.94007459
92MYC_18358816_ChIP-ChIP_MESCs_Mouse0.93458775
93PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93422231
94NANOG_16153702_ChIP-ChIP_HESCs_Human0.93219479
95SMAD3_21741376_ChIP-Seq_EPCs_Human0.93133718
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90953046
97CBP_20019798_ChIP-Seq_JUKART_Human0.90953046
98CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.90331647
99GATA3_21878914_ChIP-Seq_MCF-7_Human0.89228943
100NANOG_19829295_ChIP-Seq_ESCs_Human0.87209370

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation7.17662363
2MP0006292_abnormal_olfactory_placode3.98414090
3MP0000566_synostosis2.42485391
4MP0003136_yellow_coat_color2.39822073
5MP0006072_abnormal_retinal_apoptosis2.30325598
6MP0002938_white_spotting2.21708265
7MP0004142_abnormal_muscle_tone2.16958025
8MP0008789_abnormal_olfactory_epithelium2.15093837
9MP0002102_abnormal_ear_morphology2.13328744
10MP0004742_abnormal_vestibular_system2.07132478
11MP0003880_abnormal_central_pattern2.00801177
12MP0003122_maternal_imprinting1.98276412
13MP0001485_abnormal_pinna_reflex1.98105487
14MP0001968_abnormal_touch/_nociception1.91305337
15MP0010030_abnormal_orbit_morphology1.84619964
16MP0000778_abnormal_nervous_system1.81144581
17MP0002638_abnormal_pupillary_reflex1.80463950
18MP0002653_abnormal_ependyma_morphology1.75842151
19MP0005499_abnormal_olfactory_system1.74383308
20MP0005394_taste/olfaction_phenotype1.74383308
21MP0000049_abnormal_middle_ear1.73085672
22MP0001293_anophthalmia1.65857352
23MP0005084_abnormal_gallbladder_morpholo1.63807304
24MP0004885_abnormal_endolymph1.60307392
25MP0003787_abnormal_imprinting1.60252533
26MP0003890_abnormal_embryonic-extraembry1.58923922
27MP0003878_abnormal_ear_physiology1.55152606
28MP0005377_hearing/vestibular/ear_phenot1.55152606
29MP0004133_heterotaxia1.54590476
30MP0000026_abnormal_inner_ear1.53602669
31MP0000569_abnormal_digit_pigmentation1.53533049
32MP0008877_abnormal_DNA_methylation1.52564109
33MP0003121_genomic_imprinting1.47211820
34MP0006276_abnormal_autonomic_nervous1.47173212
35MP0000631_abnormal_neuroendocrine_gland1.45288099
36MP0009745_abnormal_behavioral_response1.40415125
37MP0002272_abnormal_nervous_system1.39806778
38MP0002736_abnormal_nociception_after1.39379195
39MP0005646_abnormal_pituitary_gland1.37400076
40MP0002837_dystrophic_cardiac_calcinosis1.36058422
41MP0005551_abnormal_eye_electrophysiolog1.33576686
42MP0002557_abnormal_social/conspecific_i1.33540538
43MP0004145_abnormal_muscle_electrophysio1.30847530
44MP0003011_delayed_dark_adaptation1.28631038
45MP0001529_abnormal_vocalization1.28239488
46MP0003938_abnormal_ear_development1.27659787
47MP0002095_abnormal_skin_pigmentation1.24886502
48MP0005423_abnormal_somatic_nervous1.24875417
49MP0002277_abnormal_respiratory_mucosa1.23463353
50MP0001486_abnormal_startle_reflex1.22972991
51MP0008995_early_reproductive_senescence1.20065912
52MP0002163_abnormal_gland_morphology1.14061989
53MP0005253_abnormal_eye_physiology1.14034226
54MP0001905_abnormal_dopamine_level1.13732999
55MP0001963_abnormal_hearing_physiology1.13506829
56MP0002234_abnormal_pharynx_morphology1.13106148
57MP0002184_abnormal_innervation1.11535353
58MP0002752_abnormal_somatic_nervous1.11237971
59MP0001188_hyperpigmentation1.10790430
60MP0001286_abnormal_eye_development1.09862182
61MP0000955_abnormal_spinal_cord1.06384816
62MP0002572_abnormal_emotion/affect_behav1.05762590
63MP0002067_abnormal_sensory_capabilities1.05363542
64MP0001984_abnormal_olfaction1.04755488
65MP0003283_abnormal_digestive_organ1.03234809
66MP0002822_catalepsy1.02995784
67MP0002064_seizures1.02545212
68MP0005174_abnormal_tail_pigmentation1.02526143
69MP0001440_abnormal_grooming_behavior1.01450134
70MP0001986_abnormal_taste_sensitivity1.00894522
71MP0005195_abnormal_posterior_eye1.00103364
72MP0003123_paternal_imprinting0.99054943
73MP0008875_abnormal_xenobiotic_pharmacok0.97973000
74MP0003937_abnormal_limbs/digits/tail_de0.95610399
75MP0003119_abnormal_digestive_system0.95129307
76MP0002735_abnormal_chemical_nociception0.94450064
77MP0003186_abnormal_redox_activity0.93256336
78MP0003315_abnormal_perineum_morphology0.91844065
79MP0010386_abnormal_urinary_bladder0.91755201
80MP0002282_abnormal_trachea_morphology0.91719429
81MP0002734_abnormal_mechanical_nocicepti0.89042800
82MP0003635_abnormal_synaptic_transmissio0.87878035
83MP0005645_abnormal_hypothalamus_physiol0.82579764
84MP0002233_abnormal_nose_morphology0.82317029
85MP0002063_abnormal_learning/memory/cond0.82167608
86MP0002751_abnormal_autonomic_nervous0.81601502
87MP0009046_muscle_twitch0.80425277
88MP0002928_abnormal_bile_duct0.80163820
89MP0001970_abnormal_pain_threshold0.80081213
90MP0005391_vision/eye_phenotype0.79848762
91MP0002697_abnormal_eye_size0.78702084
92MP0008872_abnormal_physiological_respon0.78143558
93MP0003567_abnormal_fetal_cardiomyocyte0.76008204
94MP0001879_abnormal_lymphatic_vessel0.75599001
95MP0001502_abnormal_circadian_rhythm0.74768731
96MP0003861_abnormal_nervous_system0.74627443
97MP0002210_abnormal_sex_determination0.73184565
98MP0002882_abnormal_neuron_morphology0.72230965
99MP0003718_maternal_effect0.71910391
100MP0008058_abnormal_DNA_repair0.70364884

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)6.20064487
2Abnormality of cells of the erythroid lineage (HP:0012130)5.57518729
3Abnormal number of erythroid precursors (HP:0012131)5.17621801
4Macrocytic anemia (HP:0001972)4.70652810
5Acute necrotizing encephalopathy (HP:0006965)4.44369439
6Septo-optic dysplasia (HP:0100842)4.22486152
7Congenital, generalized hypertrichosis (HP:0004540)3.98085441
8Acute encephalopathy (HP:0006846)3.86135962
9Abnormal mitochondria in muscle tissue (HP:0008316)3.84363327
10Mitochondrial inheritance (HP:0001427)3.81064267
11Increased hepatocellular lipid droplets (HP:0006565)3.78076896
12Pallor (HP:0000980)3.65073279
13Progressive macrocephaly (HP:0004481)3.56477817
14Lipid accumulation in hepatocytes (HP:0006561)3.29329385
15Pancreatic fibrosis (HP:0100732)3.29117584
16Increased CSF lactate (HP:0002490)3.15670381
17Congenital stationary night blindness (HP:0007642)3.10302129
18Pancreatic cysts (HP:0001737)3.05560492
19Molar tooth sign on MRI (HP:0002419)2.90741007
20Abnormality of midbrain morphology (HP:0002418)2.90741007
21Renal Fanconi syndrome (HP:0001994)2.90325259
22Hepatocellular necrosis (HP:0001404)2.88260919
23True hermaphroditism (HP:0010459)2.79106238
24Aplastic anemia (HP:0001915)2.77995870
253-Methylglutaconic aciduria (HP:0003535)2.77727714
26Optic disc pallor (HP:0000543)2.64715191
27Absent septum pellucidum (HP:0001331)2.61449892
28Myokymia (HP:0002411)2.56884369
29Cerebral edema (HP:0002181)2.53631372
30Exertional dyspnea (HP:0002875)2.53517621
31Maternal diabetes (HP:0009800)2.52890497
32Colon cancer (HP:0003003)2.51677441
33Partial duplication of thumb phalanx (HP:0009944)2.51370152
34Optic nerve hypoplasia (HP:0000609)2.47474047
35Pendular nystagmus (HP:0012043)2.46559426
36Hepatic necrosis (HP:0002605)2.45894143
37Nephronophthisis (HP:0000090)2.45185877
38Sclerocornea (HP:0000647)2.43992159
39Anophthalmia (HP:0000528)2.37946536
40Stenosis of the external auditory canal (HP:0000402)2.32229654
41Increased intramyocellular lipid droplets (HP:0012240)2.31935555
42Oligodactyly (hands) (HP:0001180)2.30921511
43Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.28620396
44Decreased activity of mitochondrial respiratory chain (HP:0008972)2.26783919
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.26783919
46Partial duplication of the phalanx of hand (HP:0009999)2.26369248
47Rib fusion (HP:0000902)2.24842010
48Bilateral microphthalmos (HP:0007633)2.22763711
49Depressed nasal ridge (HP:0000457)2.18329365
50Type II lissencephaly (HP:0007260)2.17357148
51Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.16499109
52Medial flaring of the eyebrow (HP:0010747)2.15679555
53Concave nail (HP:0001598)2.11542123
54Abnormality of renal resorption (HP:0011038)2.10937011
55Hyperglycinemia (HP:0002154)2.10669230
56Aplasia/Hypoplasia of the sacrum (HP:0008517)2.08940097
57Focal motor seizures (HP:0011153)2.08256963
58Abnormality of the septum pellucidum (HP:0007375)2.06653483
59Abnormality of the labia minora (HP:0012880)2.06200799
60Triphalangeal thumb (HP:0001199)2.03233735
61Abnormality of the renal medulla (HP:0100957)2.00859797
62Esophageal atresia (HP:0002032)2.00698521
63Degeneration of the lateral corticospinal tracts (HP:0002314)2.00255584
64Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.00255584
65Respiratory difficulties (HP:0002880)1.94312650
66Anencephaly (HP:0002323)1.93565413
67Leukodystrophy (HP:0002415)1.92597800
68Abnormal ciliary motility (HP:0012262)1.91742882
69Cystic liver disease (HP:0006706)1.91429052
70Absent thumb (HP:0009777)1.90863234
71Hypoglycemic seizures (HP:0002173)1.90508255
72Limb dystonia (HP:0002451)1.88373177
73Abnormal respiratory epithelium morphology (HP:0012253)1.88319990
74Abnormal respiratory motile cilium morphology (HP:0005938)1.88319990
75Abolished electroretinogram (ERG) (HP:0000550)1.86983920
76Growth hormone deficiency (HP:0000824)1.86038259
77Polydipsia (HP:0001959)1.83702861
78Abnormal drinking behavior (HP:0030082)1.83702861
79Abnormal respiratory motile cilium physiology (HP:0012261)1.82767552
80Lactic acidosis (HP:0003128)1.82195259
81Increased serum lactate (HP:0002151)1.81735357
8211 pairs of ribs (HP:0000878)1.81216895
83Confusion (HP:0001289)1.78794366
84Abnormal rod and cone electroretinograms (HP:0008323)1.77970078
85Gait imbalance (HP:0002141)1.77189242
86Abnormal number of incisors (HP:0011064)1.76487638
87Male pseudohermaphroditism (HP:0000037)1.74960037
88Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.74442671
89Woolly hair (HP:0002224)1.73822599
90Holoprosencephaly (HP:0001360)1.73820549
91Hyperphosphaturia (HP:0003109)1.73274322
92Increased muscle lipid content (HP:0009058)1.72711815
93Cerebellar dysplasia (HP:0007033)1.72307033
94Duplication of thumb phalanx (HP:0009942)1.71787585
95Bony spicule pigmentary retinopathy (HP:0007737)1.71517198
96Hypoplasia of the pons (HP:0012110)1.68552202
97Supernumerary spleens (HP:0009799)1.68085431
98Respiratory failure (HP:0002878)1.67703210
99Rhinitis (HP:0012384)1.66473637
100Abnormality of the renal collecting system (HP:0004742)1.66010778

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.19137416
2GRK13.06682420
3STK163.04299944
4EPHB22.95950139
5NME12.83593634
6ADRBK22.75378432
7WNK32.72887284
8DYRK22.63679442
9PNCK2.44546253
10WNK42.32862756
11TLK12.23130532
12VRK11.95497198
13MAPK151.91975992
14TNIK1.84523179
15PASK1.78571570
16PINK11.78273884
17MARK11.76343607
18STK391.71151625
19BUB11.62067572
20ZAK1.59051131
21BMPR1B1.54679153
22TIE11.53578025
23NUAK11.50894133
24TGFBR11.49878382
25CDC71.49185075
26OXSR11.40644208
27DYRK31.39218670
28CASK1.33014688
29PRKCG1.24870317
30MKNK21.22093218
31CDK191.18019533
32MAP3K41.15889667
33PLK41.13674163
34TAF11.12182136
35TSSK61.11084255
36MAPK131.10703572
37ADRBK11.09503146
38MAP3K121.09081804
39MAP2K71.03004733
40EPHA41.01771794
41INSRR1.00612232
42TYRO30.99208439
43MKNK10.97907622
44NTRK20.92067157
45PIK3CA0.91758060
46WEE10.91297734
47PAK30.89640717
48SRPK10.89166557
49LRRK20.87729277
50NEK20.86563208
51MAP2K40.86501480
52WNK10.82797296
53DYRK1A0.81719490
54ABL20.77127525
55PLK30.76888509
56MINK10.76318953
57NEK10.75853942
58AURKB0.73451572
59CSNK2A20.70081417
60MUSK0.67463169
61TXK0.66726653
62ERBB20.66192798
63RPS6KA50.65912020
64OBSCN0.65865107
65CHEK20.65030690
66NTRK30.64641816
67PRKACA0.63256877
68TEC0.63190403
69BCKDK0.62427668
70MAP4K20.61129168
71CAMK10.61089213
72SIK20.60456398
73CDK30.59966016
74PRKG10.56731554
75CSNK1E0.56505188
76UHMK10.56055510
77CSNK2A10.53837176
78PHKG10.53474111
79PHKG20.53474111
80MAP3K110.53402133
81PLK10.51670812
82AURKA0.51353397
83STK110.48293643
84CDK80.45348418
85DAPK30.45296171
86TAOK30.44143973
87CSNK1A10.43199947
88SGK10.42502658
89FGFR20.40715913
90CAMK2A0.38232084
91PRKACB0.37193218
92ACVR1B0.37025598
93PRKCE0.36870774
94MAP2K20.36761194
95SGK4940.36494534
96SGK2230.36494534
97STK38L0.36313655
98PRKCQ0.34317582
99DAPK20.30442815
100PRKCZ0.30219756

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.57236939
2Oxidative phosphorylation_Homo sapiens_hsa001905.14257362
3Parkinsons disease_Homo sapiens_hsa050124.43819969
4Huntingtons disease_Homo sapiens_hsa050163.12349336
5Alzheimers disease_Homo sapiens_hsa050103.09195147
6Cardiac muscle contraction_Homo sapiens_hsa042603.02294579
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.81417665
8Protein export_Homo sapiens_hsa030602.46557491
9RNA polymerase_Homo sapiens_hsa030202.46385854
10Nicotine addiction_Homo sapiens_hsa050331.91128469
11Proteasome_Homo sapiens_hsa030501.90736616
12Linoleic acid metabolism_Homo sapiens_hsa005911.81518213
13Phototransduction_Homo sapiens_hsa047441.67073393
14Sulfur relay system_Homo sapiens_hsa041221.59731573
15Homologous recombination_Homo sapiens_hsa034401.41095353
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39352172
17Basal transcription factors_Homo sapiens_hsa030221.28614939
18Spliceosome_Homo sapiens_hsa030401.27380538
19RNA degradation_Homo sapiens_hsa030181.24585115
20Nitrogen metabolism_Homo sapiens_hsa009101.21282576
21Mismatch repair_Homo sapiens_hsa034301.21166282
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14259454
23Fanconi anemia pathway_Homo sapiens_hsa034601.11028637
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10558210
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07689936
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.04292055
27Basal cell carcinoma_Homo sapiens_hsa052171.03179895
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00432932
29Fat digestion and absorption_Homo sapiens_hsa049750.99942483
30Nucleotide excision repair_Homo sapiens_hsa034200.94654640
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92215831
32Caffeine metabolism_Homo sapiens_hsa002320.90639307
33Butanoate metabolism_Homo sapiens_hsa006500.81628989
34Chemical carcinogenesis_Homo sapiens_hsa052040.81215693
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80462511
36DNA replication_Homo sapiens_hsa030300.79604918
37Taste transduction_Homo sapiens_hsa047420.79435742
38Morphine addiction_Homo sapiens_hsa050320.79420278
39Ether lipid metabolism_Homo sapiens_hsa005650.77261748
40Arachidonic acid metabolism_Homo sapiens_hsa005900.76059811
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76043174
42Purine metabolism_Homo sapiens_hsa002300.76014808
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75189975
44Pyrimidine metabolism_Homo sapiens_hsa002400.73866211
45RNA transport_Homo sapiens_hsa030130.73854458
46Olfactory transduction_Homo sapiens_hsa047400.71694763
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69741497
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69611540
49Folate biosynthesis_Homo sapiens_hsa007900.67286080
50GABAergic synapse_Homo sapiens_hsa047270.62364358
51Circadian entrainment_Homo sapiens_hsa047130.62093095
52Hedgehog signaling pathway_Homo sapiens_hsa043400.61296006
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60942642
54Collecting duct acid secretion_Homo sapiens_hsa049660.60935636
55Metabolic pathways_Homo sapiens_hsa011000.59717684
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59632217
57Tryptophan metabolism_Homo sapiens_hsa003800.59329520
58Cocaine addiction_Homo sapiens_hsa050300.58964116
59Glutamatergic synapse_Homo sapiens_hsa047240.56086404
60Peroxisome_Homo sapiens_hsa041460.56077068
61Serotonergic synapse_Homo sapiens_hsa047260.56066161
62Retinol metabolism_Homo sapiens_hsa008300.54348417
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53768749
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.53389466
65Vitamin digestion and absorption_Homo sapiens_hsa049770.52393108
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50126635
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49695738
68One carbon pool by folate_Homo sapiens_hsa006700.49591535
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.46877192
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41716313
71Regulation of autophagy_Homo sapiens_hsa041400.41489894
72Wnt signaling pathway_Homo sapiens_hsa043100.41462526
73Insulin secretion_Homo sapiens_hsa049110.40687603
74Selenocompound metabolism_Homo sapiens_hsa004500.40446170
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39951564
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37961066
77Asthma_Homo sapiens_hsa053100.37554311
78Axon guidance_Homo sapiens_hsa043600.37128249
79Glutathione metabolism_Homo sapiens_hsa004800.34960640
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33636144
81Base excision repair_Homo sapiens_hsa034100.30241478
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29729143
83Dopaminergic synapse_Homo sapiens_hsa047280.29286907
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28512741
85Propanoate metabolism_Homo sapiens_hsa006400.26302208
86Ovarian steroidogenesis_Homo sapiens_hsa049130.25608689
87Cholinergic synapse_Homo sapiens_hsa047250.25532367
88Melanogenesis_Homo sapiens_hsa049160.24467966
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.23307205
90Systemic lupus erythematosus_Homo sapiens_hsa053220.22556948
91Hippo signaling pathway_Homo sapiens_hsa043900.21543909
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.20604652
93Notch signaling pathway_Homo sapiens_hsa043300.20536484
94Tyrosine metabolism_Homo sapiens_hsa003500.20242737
95Pyruvate metabolism_Homo sapiens_hsa006200.20161521
96Amphetamine addiction_Homo sapiens_hsa050310.18999720
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.18365768
98Salivary secretion_Homo sapiens_hsa049700.16972271
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.15631147
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.15295338

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