RPL6P21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)8.01435892
2translational termination (GO:0006415)7.69591379
3ribosomal small subunit biogenesis (GO:0042274)6.83218613
4ribosomal small subunit assembly (GO:0000028)6.64427531
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.49021253
6translational elongation (GO:0006414)6.42048058
7cotranslational protein targeting to membrane (GO:0006613)6.41437727
8protein targeting to ER (GO:0045047)6.35237477
9establishment of protein localization to endoplasmic reticulum (GO:0072599)6.09638673
10maturation of SSU-rRNA (GO:0030490)6.02228904
11protein localization to endoplasmic reticulum (GO:0070972)5.99339322
12viral life cycle (GO:0019058)5.87612745
13cellular protein complex disassembly (GO:0043624)5.83769410
14behavioral response to nicotine (GO:0035095)5.81251820
15nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.67855855
16protein complex disassembly (GO:0043241)4.97303232
17establishment of protein localization to mitochondrial membrane (GO:0090151)4.89131957
18translational initiation (GO:0006413)4.88922824
19ATP synthesis coupled proton transport (GO:0015986)4.81493462
20energy coupled proton transport, down electrochemical gradient (GO:0015985)4.81493462
21macromolecular complex disassembly (GO:0032984)4.72763446
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.38757613
23protein targeting to membrane (GO:0006612)4.31181414
24cell proliferation in forebrain (GO:0021846)4.30985341
25protein complex biogenesis (GO:0070271)4.20311078
26mitochondrial respiratory chain complex I assembly (GO:0032981)4.11818724
27NADH dehydrogenase complex assembly (GO:0010257)4.11818724
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.11818724
29nuclear-transcribed mRNA catabolic process (GO:0000956)4.03767763
30chaperone-mediated protein transport (GO:0072321)4.02292828
31mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.01634063
32axon ensheathment in central nervous system (GO:0032291)3.85175801
33central nervous system myelination (GO:0022010)3.85175801
34mitochondrial respiratory chain complex assembly (GO:0033108)3.84217907
35translation (GO:0006412)3.84076308
36mRNA catabolic process (GO:0006402)3.80965397
37pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.74556640
38nonmotile primary cilium assembly (GO:0035058)3.68963809
39ribosomal large subunit biogenesis (GO:0042273)3.58920964
40pattern specification involved in kidney development (GO:0061004)3.58657662
41substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.49453014
42substrate-independent telencephalic tangential migration (GO:0021826)3.49453014
43regulation of cilium movement (GO:0003352)3.48829196
44auditory receptor cell differentiation (GO:0042491)3.46796195
45RNA catabolic process (GO:0006401)3.42391901
46respiratory electron transport chain (GO:0022904)3.42223945
47electron transport chain (GO:0022900)3.37613919
48cellular component biogenesis (GO:0044085)3.35302246
49protein neddylation (GO:0045116)3.29044870
50pyrimidine nucleotide catabolic process (GO:0006244)3.25869931
51tongue development (GO:0043586)3.24262741
52water-soluble vitamin biosynthetic process (GO:0042364)3.22027406
53nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.20879061
54somite development (GO:0061053)3.19778786
55ribonucleoprotein complex biogenesis (GO:0022613)3.17529921
56neuron fate determination (GO:0048664)3.14605862
57negative regulation of response to food (GO:0032096)3.09882418
58negative regulation of appetite (GO:0032099)3.09882418
59epithelial cilium movement (GO:0003351)3.05820036
60telencephalon development (GO:0021537)3.01224125
61exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.99903995
62establishment of protein localization to membrane (GO:0090150)2.96803753
63RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.96565476
64tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.96565476
65pyrimidine nucleobase catabolic process (GO:0006208)2.95558426
66ATP biosynthetic process (GO:0006754)2.90815530
67nephron epithelium morphogenesis (GO:0072088)2.90617399
68nephron tubule morphogenesis (GO:0072078)2.90617399
69neurofilament cytoskeleton organization (GO:0060052)2.89604666
70spinal cord association neuron differentiation (GO:0021527)2.88625949
71purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.86555258
72regulation of gene silencing by RNA (GO:0060966)2.84439910
73regulation of posttranscriptional gene silencing (GO:0060147)2.84439910
74regulation of gene silencing by miRNA (GO:0060964)2.84439910
75protein-cofactor linkage (GO:0018065)2.84228776
76purine nucleoside triphosphate biosynthetic process (GO:0009145)2.82075785
77synaptic transmission, cholinergic (GO:0007271)2.80812101
78intraciliary transport (GO:0042073)2.79454078
79protein targeting (GO:0006605)2.78758473
80negative regulation of oligodendrocyte differentiation (GO:0048715)2.77622707
81postsynaptic membrane organization (GO:0001941)2.76388598
82segment specification (GO:0007379)2.76014449
83pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.73533049
84GTP biosynthetic process (GO:0006183)2.73064396
85negative regulation of astrocyte differentiation (GO:0048712)2.72878372
86regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.64293912
87pituitary gland development (GO:0021983)2.63722111
88negative regulation of transcription regulatory region DNA binding (GO:2000678)2.63467670
89positive regulation of T cell apoptotic process (GO:0070234)2.63336896
90hydrogen ion transmembrane transport (GO:1902600)2.60931715
91intracellular protein transmembrane import (GO:0044743)2.60497783
92transmission of nerve impulse (GO:0019226)2.58127555
93kynurenine metabolic process (GO:0070189)2.56362544
94establishment of protein localization to organelle (GO:0072594)2.54124178
95genetic imprinting (GO:0071514)2.51593590
96ubiquinone biosynthetic process (GO:0006744)2.50710890
97termination of RNA polymerase III transcription (GO:0006386)2.50248888
98transcription elongation from RNA polymerase III promoter (GO:0006385)2.50248888
99radial glial cell differentiation (GO:0060019)2.50195400
100neuronal stem cell maintenance (GO:0097150)2.50116106

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.99475970
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.76046530
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.72931801
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.39281511
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.94900622
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.83105966
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.62791349
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.40981390
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.36056314
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.34569400
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.16064867
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.09673098
13CBX2_27304074_Chip-Seq_ESCs_Mouse2.07099189
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.06066407
15BMI1_23680149_ChIP-Seq_NPCS_Mouse2.02383982
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.01975244
17VDR_22108803_ChIP-Seq_LS180_Human1.94584843
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87889241
19EED_16625203_ChIP-ChIP_MESCs_Mouse1.86887535
20REST_21632747_ChIP-Seq_MESCs_Mouse1.86394719
21ZNF274_21170338_ChIP-Seq_K562_Hela1.81821135
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.74442879
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.73787137
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.73654459
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63878373
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.62132458
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.58915992
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.58638081
29IRF1_19129219_ChIP-ChIP_H3396_Human1.58603890
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.58548316
31POU5F1_16153702_ChIP-ChIP_HESCs_Human1.55876621
32SOX2_16153702_ChIP-ChIP_HESCs_Human1.54234197
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.50751227
34RNF2_27304074_Chip-Seq_NSC_Mouse1.49459247
35TTF2_22483619_ChIP-Seq_HELA_Human1.44854772
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41777501
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41716468
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.40639238
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.40214812
40XRN2_22483619_ChIP-Seq_HELA_Human1.39170459
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.38998938
42IGF1R_20145208_ChIP-Seq_DFB_Human1.38548843
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.36450521
44SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35748235
45SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.35391759
46RNF2_18974828_ChIP-Seq_MESCs_Mouse1.32955008
47EZH2_18974828_ChIP-Seq_MESCs_Mouse1.32955008
48CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.31644126
49ELK1_19687146_ChIP-ChIP_HELA_Human1.26267958
50FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.24453771
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21712022
52GBX2_23144817_ChIP-Seq_PC3_Human1.20999486
53ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18846962
54RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18840721
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18078390
56GATA1_26923725_Chip-Seq_HPCs_Mouse1.16996448
57SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13978856
58SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13709864
59MYC_18940864_ChIP-ChIP_HL60_Human1.13559176
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13434299
61FUS_26573619_Chip-Seq_HEK293_Human1.13247937
62GATA3_21878914_ChIP-Seq_MCF-7_Human1.13140797
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11577415
64NCOR_22424771_ChIP-Seq_293T_Human1.10002505
65P300_19829295_ChIP-Seq_ESCs_Human1.09640178
66SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09492105
67TP53_22573176_ChIP-Seq_HFKS_Human1.09262469
68RING1B_27294783_Chip-Seq_ESCs_Mouse1.09262222
69CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.08367827
70GABP_19822575_ChIP-Seq_HepG2_Human1.08292207
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08181273
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.08139060
73FOXP3_21729870_ChIP-Seq_TREG_Human1.06888237
74TDRD3_21172665_ChIP-Seq_MCF-7_Human1.06326843
75ERA_21632823_ChIP-Seq_H3396_Human1.05435164
76GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05191358
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04553815
78VDR_23849224_ChIP-Seq_CD4+_Human1.03585856
79ERG_21242973_ChIP-ChIP_JURKAT_Human1.03567358
80TAF2_19829295_ChIP-Seq_ESCs_Human1.03079303
81ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01767464
82TP53_20018659_ChIP-ChIP_R1E_Mouse1.00300041
83NANOG_20526341_ChIP-Seq_ESCs_Human0.97773913
84EWS_26573619_Chip-Seq_HEK293_Human0.95802221
85NOTCH1_21737748_ChIP-Seq_TLL_Human0.95455441
86RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93094287
87SMAD3_21741376_ChIP-Seq_ESCs_Human0.93004856
88NANOG_16153702_ChIP-ChIP_HESCs_Human0.92170805
89MYC_18358816_ChIP-ChIP_MESCs_Mouse0.92152921
90CTCF_27219007_Chip-Seq_Bcells_Human0.91971583
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91878211
92CTCF_18555785_ChIP-Seq_MESCs_Mouse0.91519064
93EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.91138509
94TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.88815645
95SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88558450
96ELK1_22589737_ChIP-Seq_MCF10A_Human0.88235278
97TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87704858
98MYC_19079543_ChIP-ChIP_MESCs_Mouse0.87379092
99PCGF2_27294783_Chip-Seq_NPCs_Mouse0.86204444
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85263810

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.32880941
2MP0006292_abnormal_olfactory_placode5.25945932
3MP0002653_abnormal_ependyma_morphology2.84793871
4MP0003122_maternal_imprinting2.80215087
5MP0001986_abnormal_taste_sensitivity2.79968554
6MP0003136_yellow_coat_color2.66768471
7MP0003787_abnormal_imprinting2.56742399
8MP0003123_paternal_imprinting2.50507672
9MP0008789_abnormal_olfactory_epithelium2.36745155
10MP0003646_muscle_fatigue2.24075502
11MP0005423_abnormal_somatic_nervous2.22770924
12MP0005394_taste/olfaction_phenotype2.17115606
13MP0005499_abnormal_olfactory_system2.17115606
14MP0002277_abnormal_respiratory_mucosa2.15634622
15MP0001293_anophthalmia2.09176925
16MP0002163_abnormal_gland_morphology2.08723486
17MP0003121_genomic_imprinting1.99095878
18MP0002837_dystrophic_cardiac_calcinosis1.95031012
19MP0001485_abnormal_pinna_reflex1.92300379
20MP0004142_abnormal_muscle_tone1.86816802
21MP0000778_abnormal_nervous_system1.84423631
22MP0000049_abnormal_middle_ear1.78998060
23MP0001529_abnormal_vocalization1.77434795
24MP0001984_abnormal_olfaction1.77416130
25MP0002736_abnormal_nociception_after1.63060840
26MP0002272_abnormal_nervous_system1.58440314
27MP0001968_abnormal_touch/_nociception1.57399407
28MP0004133_heterotaxia1.55151158
29MP0005084_abnormal_gallbladder_morpholo1.54853259
30MP0000631_abnormal_neuroendocrine_gland1.46789015
31MP0005377_hearing/vestibular/ear_phenot1.45356976
32MP0003878_abnormal_ear_physiology1.45356976
33MP0008877_abnormal_DNA_methylation1.43751477
34MP0005646_abnormal_pituitary_gland1.38283795
35MP0002876_abnormal_thyroid_physiology1.34972748
36MP0002095_abnormal_skin_pigmentation1.34624307
37MP0005551_abnormal_eye_electrophysiolog1.32445235
38MP0003938_abnormal_ear_development1.28601772
39MP0006276_abnormal_autonomic_nervous1.22942018
40MP0004885_abnormal_endolymph1.20316887
41MP0002938_white_spotting1.19574729
42MP0005195_abnormal_posterior_eye1.18427030
43MP0000026_abnormal_inner_ear1.17244923
44MP0000955_abnormal_spinal_cord1.14514000
45MP0002102_abnormal_ear_morphology1.14171129
46MP0002752_abnormal_somatic_nervous1.13315313
47MP0001486_abnormal_startle_reflex1.13072950
48MP0008872_abnormal_physiological_respon1.11400130
49MP0003011_delayed_dark_adaptation1.11201205
50MP0009745_abnormal_behavioral_response1.10973510
51MP0001905_abnormal_dopamine_level1.10771975
52MP0002735_abnormal_chemical_nociception1.10676486
53MP0005379_endocrine/exocrine_gland_phen1.10213545
54MP0002557_abnormal_social/conspecific_i1.10126764
55MP0009250_abnormal_appendicular_skeleto1.08998583
56MP0009053_abnormal_anal_canal1.08084351
57MP0002734_abnormal_mechanical_nocicepti1.07026597
58MP0000566_synostosis1.06929246
59MP0001286_abnormal_eye_development1.04829471
60MP0002233_abnormal_nose_morphology1.04779225
61MP0002184_abnormal_innervation1.03134058
62MP0000372_irregular_coat_pigmentation1.02651567
63MP0002063_abnormal_learning/memory/cond1.02450858
64MP0000569_abnormal_digit_pigmentation1.02371655
65MP0002572_abnormal_emotion/affect_behav1.01671972
66MP0003635_abnormal_synaptic_transmissio1.01460060
67MP0003755_abnormal_palate_morphology1.01357280
68MP0001440_abnormal_grooming_behavior1.00649867
69MP0003942_abnormal_urinary_system1.00443268
70MP0001324_abnormal_eye_pigmentation0.99527380
71MP0001963_abnormal_hearing_physiology0.98555539
72MP0009046_muscle_twitch0.97631339
73MP0001970_abnormal_pain_threshold0.97380348
74MP0003880_abnormal_central_pattern0.96786152
75MP0004145_abnormal_muscle_electrophysio0.96780130
76MP0002210_abnormal_sex_determination0.92287960
77MP0002638_abnormal_pupillary_reflex0.89860336
78MP0002064_seizures0.89680754
79MP0006072_abnormal_retinal_apoptosis0.89060229
80MP0003315_abnormal_perineum_morphology0.86508675
81MP0010030_abnormal_orbit_morphology0.85620577
82MP0005174_abnormal_tail_pigmentation0.85541707
83MP0003937_abnormal_limbs/digits/tail_de0.84977511
84MP0004859_abnormal_synaptic_plasticity0.83992043
85MP0002882_abnormal_neuron_morphology0.83066202
86MP0002138_abnormal_hepatobiliary_system0.82708939
87MP0002160_abnormal_reproductive_system0.80096525
88MP0008875_abnormal_xenobiotic_pharmacok0.79920376
89MP0002152_abnormal_brain_morphology0.76576173
90MP0002067_abnormal_sensory_capabilities0.74497277
91MP0002733_abnormal_thermal_nociception0.73296410
92MP0003693_abnormal_embryo_hatching0.72613124
93MP0005645_abnormal_hypothalamus_physiol0.71600133
94MP0001188_hyperpigmentation0.71123378
95MP0005253_abnormal_eye_physiology0.70929018
96MP0005389_reproductive_system_phenotype0.69785857
97MP0003567_abnormal_fetal_cardiomyocyte0.69250776
98MP0002116_abnormal_craniofacial_bone0.68632199
99MP0002249_abnormal_larynx_morphology0.67139434
100MP0000230_abnormal_systemic_arterial0.66385947

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)5.52711661
2Reticulocytopenia (HP:0001896)4.83877774
3Abnormality of cells of the erythroid lineage (HP:0012130)4.78569976
4Acute necrotizing encephalopathy (HP:0006965)4.19163675
5Macrocytic anemia (HP:0001972)4.00820006
6Abnormal number of erythroid precursors (HP:0012131)3.97585051
7Abnormal mitochondria in muscle tissue (HP:0008316)3.64429538
8Molar tooth sign on MRI (HP:0002419)3.55444071
9Abnormality of midbrain morphology (HP:0002418)3.55444071
10Mitochondrial inheritance (HP:0001427)3.55080728
11Acute encephalopathy (HP:0006846)3.36620617
12Progressive macrocephaly (HP:0004481)3.27995031
13Maternal diabetes (HP:0009800)3.24586176
14Type II lissencephaly (HP:0007260)3.21092668
15Absent septum pellucidum (HP:0001331)3.16273662
16Nephronophthisis (HP:0000090)3.16227345
17Pancreatic fibrosis (HP:0100732)3.11319074
18Increased CSF lactate (HP:0002490)3.05398253
19Adrenal hypoplasia (HP:0000835)3.01071959
20Medial flaring of the eyebrow (HP:0010747)2.93988078
21Hepatocellular necrosis (HP:0001404)2.85629990
22Pallor (HP:0000980)2.85497250
23Cerebral edema (HP:0002181)2.74244069
24Absent rod-and cone-mediated responses on ERG (HP:0007688)2.67409028
25True hermaphroditism (HP:0010459)2.63311158
26Optic nerve hypoplasia (HP:0000609)2.62170468
27Hepatic necrosis (HP:0002605)2.60158104
28Rib fusion (HP:0000902)2.58983355
29Increased hepatocellular lipid droplets (HP:0006565)2.55179568
30Pancreatic cysts (HP:0001737)2.51784439
31Myokymia (HP:0002411)2.51501654
32Gait imbalance (HP:0002141)2.51238583
33Abnormal rod and cone electroretinograms (HP:0008323)2.47915644
34Cerebellar dysplasia (HP:0007033)2.46239539
35Renal Fanconi syndrome (HP:0001994)2.45492988
36Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.43675233
37Lipid accumulation in hepatocytes (HP:0006561)2.41446022
38Nephrogenic diabetes insipidus (HP:0009806)2.39871874
39Abnormality of the diencephalon (HP:0010662)2.39200653
40Abnormality of the renal medulla (HP:0100957)2.39135941
41Congenital primary aphakia (HP:0007707)2.36873010
42Abnormality of the septum pellucidum (HP:0007375)2.33571447
43Sclerocornea (HP:0000647)2.33370310
44Hyperglycinemia (HP:0002154)2.30999775
45Pendular nystagmus (HP:0012043)2.30816653
46Lissencephaly (HP:0001339)2.28304756
47Stenosis of the external auditory canal (HP:0000402)2.27912806
48Abnormality of renal resorption (HP:0011038)2.27175137
49Anencephaly (HP:0002323)2.22732650
50Optic disc pallor (HP:0000543)2.22258568
51Aplasia/Hypoplasia of the spleen (HP:0010451)2.19966414
52Aplasia/Hypoplasia of the sacrum (HP:0008517)2.19891606
53Asplenia (HP:0001746)2.16018450
54Diastasis recti (HP:0001540)2.14484111
55Depressed nasal ridge (HP:0000457)2.06679784
56Limb dystonia (HP:0002451)2.06052614
57Leukodystrophy (HP:0002415)2.04783925
58Decreased central vision (HP:0007663)2.03938128
59Growth hormone deficiency (HP:0000824)2.00085167
60Abnormality of the corticospinal tract (HP:0002492)2.00080421
61Congenital stationary night blindness (HP:0007642)1.99344081
623-Methylglutaconic aciduria (HP:0003535)1.98773766
63Short femoral neck (HP:0100864)1.97098246
64Pachygyria (HP:0001302)1.94479398
65Abnormal number of incisors (HP:0011064)1.93688953
66Holoprosencephaly (HP:0001360)1.92740090
67Abnormality of the labia minora (HP:0012880)1.92423403
68Chronic hepatic failure (HP:0100626)1.91022134
69Thyroid-stimulating hormone excess (HP:0002925)1.90313744
70Enlarged penis (HP:0000040)1.89688560
71Absent thumb (HP:0009777)1.87490460
72Methylmalonic acidemia (HP:0002912)1.85038221
73Abnormal drinking behavior (HP:0030082)1.80906887
74Polydipsia (HP:0001959)1.80906887
75Anomalous pulmonary venous return (HP:0010772)1.79779538
7611 pairs of ribs (HP:0000878)1.79438199
77Porencephaly (HP:0002132)1.79272109
78Cystic liver disease (HP:0006706)1.78595822
79Vaginal atresia (HP:0000148)1.74786001
80Hip dysplasia (HP:0001385)1.74759902
81Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.74369858
82Anophthalmia (HP:0000528)1.73193066
83Lethargy (HP:0001254)1.73079827
84Renal dysplasia (HP:0000110)1.71594899
85Genital tract atresia (HP:0001827)1.71143875
86Hyperthyroidism (HP:0000836)1.70906909
87Hypoplasia of the radius (HP:0002984)1.70402355
88Severe muscular hypotonia (HP:0006829)1.69973979
89Partial duplication of thumb phalanx (HP:0009944)1.69915182
90Oligodactyly (hands) (HP:0001180)1.69719956
91Postaxial foot polydactyly (HP:0001830)1.69620614
92Colon cancer (HP:0003003)1.68820198
93Congenital, generalized hypertrichosis (HP:0004540)1.67535796
94Neoplasm of the adrenal cortex (HP:0100641)1.66743592
95Increased serum lactate (HP:0002151)1.66519517
96Aplasia/Hypoplasia of the tongue (HP:0010295)1.65174892
97Hypoplastic pelvis (HP:0008839)1.64244432
98Poor coordination (HP:0002370)1.64050615
99Supernumerary spleens (HP:0009799)1.62808719
100Humeroradial synostosis (HP:0003041)1.62750409

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK3.99607137
2STK163.71532888
3BCKDK3.09895442
4WNK42.93366023
5TNIK2.38452947
6PINK12.34071341
7DYRK22.31780456
8CDK192.18074963
9ZAK2.17450510
10CAMK1G1.94236574
11CASK1.93557645
12PIK3CA1.90394544
13LIMK11.80929371
14MAP3K91.79325745
15PRKCG1.74234194
16ADRBK21.68536916
17MARK11.58220982
18TLK11.55231561
19TIE11.55150982
20PASK1.52107045
21MAP2K71.48250752
22CDC71.46100919
23GRK11.44728887
24ARAF1.39542204
25STK391.38162385
26BRAF1.36359478
27SGK4941.34814236
28SGK2231.34814236
29MINK11.33728980
30TAF11.33546555
31NTRK21.32611435
32SGK21.27025095
33ABL21.20714458
34RPS6KA61.19733920
35VRK11.18871496
36EPHB21.15261227
37PRKCH1.13862640
38EPHA41.13211530
39FRK1.11557460
40CAMK11.10884239
41NME11.04836208
42LRRK21.03657533
43RPS6KC11.01979330
44RPS6KL11.01979330
45NUAK11.01400877
46MAP3K40.99141188
47DYRK30.98921589
48PLK40.97012671
49AURKA0.95942918
50RPS6KA20.92701546
51MAPK150.90917871
52NME20.89759004
53WNK10.89204345
54MAP4K20.86072278
55WNK30.85876007
56ADRBK10.81626475
57TYRO30.80694994
58CAMK1D0.76881509
59NEK10.74520009
60MAP2K40.73871826
61INSRR0.72210429
62SGK30.68245043
63PRKCI0.66729603
64CSNK2A20.63808505
65PRKCQ0.63544096
66PIM20.62583767
67RPS6KA50.61831773
68PRKACA0.61259798
69NEK20.60763114
70PRKCE0.60284590
71PRKCZ0.59692494
72SGK10.59248417
73PLK30.59101541
74DYRK1A0.58734948
75PLK10.57643612
76PLK20.55124025
77CSNK2A10.54648041
78MAPK130.53872579
79VRK20.53669042
80CCNB10.52822915
81MAP3K100.51073235
82STK110.50745914
83PRKCD0.49869602
84BMPR1B0.49749186
85MAP2K20.49701250
86ATR0.48694522
87OXSR10.47998046
88PIM10.45962607
89TGFBR10.45334840
90RPS6KA10.43701733
91CSNK1E0.43377506
92AURKB0.42644881
93DAPK30.42588437
94PRKCA0.39590894
95CSNK1A10.39444573
96CAMK2A0.38792725
97MKNK20.38217710
98CSNK1G10.38055892
99IKBKB0.37956795
100OBSCN0.36371861

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.95479050
2Oxidative phosphorylation_Homo sapiens_hsa001904.12213188
3Parkinsons disease_Homo sapiens_hsa050123.48745413
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.81601105
5Cardiac muscle contraction_Homo sapiens_hsa042602.64257394
6Huntingtons disease_Homo sapiens_hsa050162.59705871
7Alzheimers disease_Homo sapiens_hsa050102.39490673
8RNA polymerase_Homo sapiens_hsa030202.28292669
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.22736872
10Protein export_Homo sapiens_hsa030601.93307430
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82752277
12Nicotine addiction_Homo sapiens_hsa050331.63470351
13Homologous recombination_Homo sapiens_hsa034401.53872034
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.53074676
15Linoleic acid metabolism_Homo sapiens_hsa005911.47302829
16One carbon pool by folate_Homo sapiens_hsa006701.46992503
17Proteasome_Homo sapiens_hsa030501.46899104
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.45178914
19Selenocompound metabolism_Homo sapiens_hsa004501.43315155
20RNA degradation_Homo sapiens_hsa030181.42765635
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37839908
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.33064096
23Butanoate metabolism_Homo sapiens_hsa006501.26371028
24Basal cell carcinoma_Homo sapiens_hsa052171.20465181
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19793940
26Steroid biosynthesis_Homo sapiens_hsa001001.19481655
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17789502
28Pyrimidine metabolism_Homo sapiens_hsa002401.17645731
29Phototransduction_Homo sapiens_hsa047441.14447752
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10572921
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10249231
32Tryptophan metabolism_Homo sapiens_hsa003801.09382455
33Fanconi anemia pathway_Homo sapiens_hsa034601.01814407
34Peroxisome_Homo sapiens_hsa041461.01387845
35Caffeine metabolism_Homo sapiens_hsa002320.98164344
36Mismatch repair_Homo sapiens_hsa034300.97170697
37Fat digestion and absorption_Homo sapiens_hsa049750.95723985
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95095181
39Insulin secretion_Homo sapiens_hsa049110.94201377
40Morphine addiction_Homo sapiens_hsa050320.93892719
41Primary bile acid biosynthesis_Homo sapiens_hsa001200.93760672
42Purine metabolism_Homo sapiens_hsa002300.91355193
43beta-Alanine metabolism_Homo sapiens_hsa004100.90426727
44Basal transcription factors_Homo sapiens_hsa030220.88079245
45Hedgehog signaling pathway_Homo sapiens_hsa043400.86756147
46Nucleotide excision repair_Homo sapiens_hsa034200.85056895
47Propanoate metabolism_Homo sapiens_hsa006400.84140208
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83976993
49DNA replication_Homo sapiens_hsa030300.79567032
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76964845
51Base excision repair_Homo sapiens_hsa034100.75691308
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75039184
53Fatty acid degradation_Homo sapiens_hsa000710.74267660
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.73805008
55Chemical carcinogenesis_Homo sapiens_hsa052040.73041296
56GABAergic synapse_Homo sapiens_hsa047270.72221243
57Metabolic pathways_Homo sapiens_hsa011000.71214969
58Olfactory transduction_Homo sapiens_hsa047400.70347793
59Ether lipid metabolism_Homo sapiens_hsa005650.70346285
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65603575
61Retinol metabolism_Homo sapiens_hsa008300.64567674
62Folate biosynthesis_Homo sapiens_hsa007900.62839348
63Axon guidance_Homo sapiens_hsa043600.62402331
64Asthma_Homo sapiens_hsa053100.60955630
65Sulfur relay system_Homo sapiens_hsa041220.56851850
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56227863
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56019555
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55828871
69Glutamatergic synapse_Homo sapiens_hsa047240.55184229
70Collecting duct acid secretion_Homo sapiens_hsa049660.53708116
71Notch signaling pathway_Homo sapiens_hsa043300.53429385
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53241699
73Cocaine addiction_Homo sapiens_hsa050300.53029134
74Taste transduction_Homo sapiens_hsa047420.52510871
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52072888
76Arachidonic acid metabolism_Homo sapiens_hsa005900.50136895
77Fatty acid metabolism_Homo sapiens_hsa012120.48761268
78Hippo signaling pathway_Homo sapiens_hsa043900.46477153
79Pyruvate metabolism_Homo sapiens_hsa006200.46103831
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45324328
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45082732
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44052014
83Systemic lupus erythematosus_Homo sapiens_hsa053220.43516554
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43091247
85Vitamin digestion and absorption_Homo sapiens_hsa049770.42829330
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.42645209
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41698588
88RNA transport_Homo sapiens_hsa030130.41129280
89Fatty acid elongation_Homo sapiens_hsa000620.39925127
90Circadian entrainment_Homo sapiens_hsa047130.39129836
91Alcoholism_Homo sapiens_hsa050340.38994287
92Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.38512764
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38487637
94Spliceosome_Homo sapiens_hsa030400.37286853
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.35996921
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.35853461
97Dopaminergic synapse_Homo sapiens_hsa047280.33092012
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31179608
99Fatty acid biosynthesis_Homo sapiens_hsa000610.30225151
100Nitrogen metabolism_Homo sapiens_hsa009100.28346827

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