ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	8.22315495
2	translational termination (GO:0006415)	7.86552545
3	ribosomal small subunit assembly (GO:0000028)	7.83357670
4	ribosomal small subunit biogenesis (GO:0042274)	7.73322799
5	maturation of SSU-rRNA (GO:0030490)	7.56267101
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.57509175
7	translational elongation (GO:0006414)	6.56864371
8	cotranslational protein targeting to membrane (GO:0006613)	6.48667725
9	protein targeting to ER (GO:0045047)	6.46377728
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.21343658
11	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.14605302
12	ATP synthesis coupled proton transport (GO:0015986)	6.14605302
13	protein localization to endoplasmic reticulum (GO:0070972)	6.05759243
14	cellular protein complex disassembly (GO:0043624)	5.93282184
15	viral life cycle (GO:0019058)	5.87347228
16	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.64474760
17	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.54692654
18	translational initiation (GO:0006413)	5.19935557
19	protein complex disassembly (GO:0043241)	5.03036417
20	chaperone-mediated protein transport (GO:0072321)	5.02644189
21	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.90836889
22	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.88958656
23	ribosomal large subunit biogenesis (GO:0042273)	4.88286451
24	protein neddylation (GO:0045116)	4.76240130
25	macromolecular complex disassembly (GO:0032984)	4.75954749
26	respiratory electron transport chain (GO:0022904)	4.38668222
27	protein complex biogenesis (GO:0070271)	4.38402956
28	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.36159755
29	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.36159755
30	NADH dehydrogenase complex assembly (GO:0010257)	4.36159755
31	behavioral response to nicotine (GO:0035095)	4.36028091
32	electron transport chain (GO:0022900)	4.34991804
33	translation (GO:0006412)	4.32658637
34	protein targeting to membrane (GO:0006612)	4.32529645
35	mitochondrial respiratory chain complex assembly (GO:0033108)	4.11061357
36	water-soluble vitamin biosynthetic process (GO:0042364)	4.08062932
37	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.95388961
38	ribonucleoprotein complex biogenesis (GO:0022613)	3.84705327
39	cellular component biogenesis (GO:0044085)	3.83605897
40	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.77790054
41	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.77790054
42	mRNA catabolic process (GO:0006402)	3.70454220
43	DNA deamination (GO:0045006)	3.65674185
44	ATP biosynthetic process (GO:0006754)	3.59729284
45	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.59079229
46	GTP biosynthetic process (GO:0006183)	3.57020719
47	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.52845076
48	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.52573957
49	cell proliferation in forebrain (GO:0021846)	3.40512036
50	hydrogen ion transmembrane transport (GO:1902600)	3.37510936
51	rRNA modification (GO:0000154)	3.28952075
52	RNA catabolic process (GO:0006401)	3.28241905
53	somite development (GO:0061053)	3.21463646
54	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.19831350
55	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.12352928
56	respiratory chain complex IV assembly (GO:0008535)	3.10952458
57	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.09415830
58	substrate-independent telencephalic tangential migration (GO:0021826)	3.09415830
59	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.09016047
60	rRNA processing (GO:0006364)	3.08600354
61	rRNA metabolic process (GO:0016072)	3.04518823
62	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.03593954
63	proton transport (GO:0015992)	3.03221262
64	termination of RNA polymerase III transcription (GO:0006386)	3.01942308
65	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.01942308
66	establishment of protein localization to membrane (GO:0090150)	2.98370566
67	UTP biosynthetic process (GO:0006228)	2.97873722
68	protein targeting (GO:0006605)	2.97786337
69	hydrogen transport (GO:0006818)	2.96967898
70	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.96763249
71	pyrimidine nucleotide catabolic process (GO:0006244)	2.93477063
72	cytochrome complex assembly (GO:0017004)	2.92183077
73	UTP metabolic process (GO:0046051)	2.89428851
74	protein-cofactor linkage (GO:0018065)	2.83434585
75	preassembly of GPI anchor in ER membrane (GO:0016254)	2.79998043
76	regulation of cilium movement (GO:0003352)	2.78557781
77	pseudouridine synthesis (GO:0001522)	2.78080594
78	establishment of protein localization to organelle (GO:0072594)	2.77792573
79	protein targeting to mitochondrion (GO:0006626)	2.76222890
80	establishment of protein localization to mitochondrion (GO:0072655)	2.75489729
81	parturition (GO:0007567)	2.70273364
82	nucleoside triphosphate biosynthetic process (GO:0009142)	2.68976093
83	intracellular protein transmembrane import (GO:0044743)	2.67968980
84	pattern specification involved in kidney development (GO:0061004)	2.67804165
85	cardiovascular system development (GO:0072358)	2.61619996
86	positive regulation of T cell apoptotic process (GO:0070234)	2.59959409
87	tRNA processing (GO:0008033)	2.59385960
88	neuron fate determination (GO:0048664)	2.57091337
89	protein localization to mitochondrion (GO:0070585)	2.56942585
90	synaptic transmission, cholinergic (GO:0007271)	2.55693264
91	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.52130694
92	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.49267397
93	CTP metabolic process (GO:0046036)	2.49055376
94	CTP biosynthetic process (GO:0006241)	2.49055376
95	epithelial cilium movement (GO:0003351)	2.46182610
96	response to pheromone (GO:0019236)	2.44888634
97	protein polyglutamylation (GO:0018095)	2.44729715
98	regulation of cellular respiration (GO:0043457)	2.43330734
99	ubiquinone biosynthetic process (GO:0006744)	2.43156402
100	protein localization to membrane (GO:0072657)	2.42979690

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.66411818
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.58238642
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.22117399
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.10005264
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.64356549
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.05779959
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.04400473
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.92473196
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.78583222
10	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.37844441
11	VDR_22108803_ChIP-Seq_LS180_Human	2.24606742
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.19380357
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.14924660
14	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.12157964
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.12064455
16	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.08241114
17	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.06509710
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.94458762
19	IRF1_19129219_ChIP-ChIP_H3396_Human	1.87673552
20	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.85344383
21	VDR_23849224_ChIP-Seq_CD4+_Human	1.78380658
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.77287185
23	MYC_18940864_ChIP-ChIP_HL60_Human	1.74719183
24	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.69425968
25	TTF2_22483619_ChIP-Seq_HELA_Human	1.68289139
26	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.66789728
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.66379457
28	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.57275132
29	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.55823934
30	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.55764112
31	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.55759518
32	XRN2_22483619_ChIP-Seq_HELA_Human	1.53656323
33	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.51461252
34	ELK1_19687146_ChIP-ChIP_HELA_Human	1.51263683
35	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.47580051
36	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.42770894
37	GABP_19822575_ChIP-Seq_HepG2_Human	1.40964361
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.39041914
39	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.38311390
40	REST_21632747_ChIP-Seq_MESCs_Mouse	1.35791248
41	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.35262288
42	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.34105687
43	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.32275519
44	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.31580098
45	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.30345450
46	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.23301034
47	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.18175534
48	TAF2_19829295_ChIP-Seq_ESCs_Human	1.18131615
49	EWS_26573619_Chip-Seq_HEK293_Human	1.17560276
50	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.17455609
51	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.17060808
52	NANOG_20526341_ChIP-Seq_ESCs_Human	1.16415377
53	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.16014453
54	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.14982936
55	ERA_21632823_ChIP-Seq_H3396_Human	1.14898516
56	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.13828580
57	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.12494726
58	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.12248978
59	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.11491939
60	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.10801492
61	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.09081148
62	RNF2_27304074_Chip-Seq_NSC_Mouse	1.08877247
63	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.08695406
64	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.08595224
65	FUS_26573619_Chip-Seq_HEK293_Human	1.08229550
66	NCOR_22424771_ChIP-Seq_293T_Human	1.07235056
67	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.03086799
68	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.02365225
69	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.01233370
70	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.99723605
71	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.98785891
72	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.98081916
73	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.98054270
74	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.97485621
75	IGF1R_20145208_ChIP-Seq_DFB_Human	0.96679791
76	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.95280917
77	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.95157642
78	MYC_19829295_ChIP-Seq_ESCs_Human	0.93410300
79	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.90856844
80	AR_20517297_ChIP-Seq_VCAP_Human	0.90721802
81	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.90632713
82	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.90537835
83	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.89953249
84	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.89953249
85	BCL6_27268052_Chip-Seq_Bcells_Human	0.89348253
86	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.88931870
87	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.88861468
88	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.88085345
89	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.87317832
90	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.86929652
91	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.86369776
92	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.85971472
93	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.85877505
94	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.84838878
95	CTCF_20526341_ChIP-Seq_ESCs_Human	0.84777820
96	P53_21459846_ChIP-Seq_SAOS-2_Human	0.83821432
97	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.83820698
98	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.81426324
99	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.81133139
100	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.80929180

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.46637332
2	MP0006292_abnormal_olfactory_placode	4.49768176
3	MP0003787_abnormal_imprinting	3.05810402
4	MP0003123_paternal_imprinting	2.73398943
5	MP0003646_muscle_fatigue	2.58404726
6	MP0003122_maternal_imprinting	2.46099968
7	MP0002163_abnormal_gland_morphology	2.43094152
8	MP0004142_abnormal_muscle_tone	2.42650626
9	MP0002653_abnormal_ependyma_morphology	2.38217480
10	MP0008877_abnormal_DNA_methylation	2.21924873
11	MP0002837_dystrophic_cardiac_calcinosis	2.13630873
12	MP0005646_abnormal_pituitary_gland	2.13381184
13	MP0008789_abnormal_olfactory_epithelium	2.13370685
14	MP0003121_genomic_imprinting	2.13019662
15	MP0008875_abnormal_xenobiotic_pharmacok	1.86038358
16	MP0001293_anophthalmia	1.81206173
17	MP0002638_abnormal_pupillary_reflex	1.79849465
18	MP0003136_yellow_coat_color	1.78758101
19	MP0000049_abnormal_middle_ear	1.75036647
20	MP0005394_taste/olfaction_phenotype	1.73812098
21	MP0005499_abnormal_olfactory_system	1.73812098
22	MP0001968_abnormal_touch/_nociception	1.68468105
23	MP0004885_abnormal_endolymph	1.61519085
24	MP0005551_abnormal_eye_electrophysiolog	1.57140214
25	MP0008872_abnormal_physiological_respon	1.54565381
26	MP0002102_abnormal_ear_morphology	1.53466625
27	MP0006276_abnormal_autonomic_nervous	1.53232285
28	MP0004145_abnormal_muscle_electrophysio	1.52945097
29	MP0001485_abnormal_pinna_reflex	1.51027879
30	MP0003186_abnormal_redox_activity	1.50275301
31	MP0002736_abnormal_nociception_after	1.42448742
32	MP0004147_increased_porphyrin_level	1.41641033
33	MP0002160_abnormal_reproductive_system	1.41486673
34	MP0002272_abnormal_nervous_system	1.40424437
35	MP0000631_abnormal_neuroendocrine_gland	1.36453298
36	MP0000778_abnormal_nervous_system	1.35433303
37	MP0001905_abnormal_dopamine_level	1.34485398
38	MP0005084_abnormal_gallbladder_morpholo	1.34230231
39	MP0006072_abnormal_retinal_apoptosis	1.33116835
40	MP0005379_endocrine/exocrine_gland_phen	1.32307547
41	MP0003011_delayed_dark_adaptation	1.31899452
42	MP0001440_abnormal_grooming_behavior	1.24781552
43	MP0005389_reproductive_system_phenotype	1.21851413
44	MP0001986_abnormal_taste_sensitivity	1.21833965
45	MP0002234_abnormal_pharynx_morphology	1.21165750
46	MP0002733_abnormal_thermal_nociception	1.18075281
47	MP0002277_abnormal_respiratory_mucosa	1.17853117
48	MP0002876_abnormal_thyroid_physiology	1.16461234
49	MP0005195_abnormal_posterior_eye	1.15437478
50	MP0005377_hearing/vestibular/ear_phenot	1.14191642
51	MP0003878_abnormal_ear_physiology	1.14191642
52	MP0001529_abnormal_vocalization	1.13782492
53	MP0002557_abnormal_social/conspecific_i	1.12046984
54	MP0002138_abnormal_hepatobiliary_system	1.09272646
55	MP0003880_abnormal_central_pattern	1.08958811
56	MP0009745_abnormal_behavioral_response	1.08298521
57	MP0001984_abnormal_olfaction	1.07415972
58	MP0001970_abnormal_pain_threshold	1.06448775
59	MP0002184_abnormal_innervation	1.03770703
60	MP0004133_heterotaxia	1.03574183
61	MP0005423_abnormal_somatic_nervous	1.03338903
62	MP0002938_white_spotting	1.03098777
63	MP0002752_abnormal_somatic_nervous	1.02552358
64	MP0009250_abnormal_appendicular_skeleto	1.01753436
65	MP0002572_abnormal_emotion/affect_behav	1.00141781
66	MP0000955_abnormal_spinal_cord	0.97947095
67	MP0003315_abnormal_perineum_morphology	0.96575599
68	MP0009053_abnormal_anal_canal	0.95830254
69	MP0000026_abnormal_inner_ear	0.95483129
70	MP0006036_abnormal_mitochondrial_physio	0.94491210
71	MP0001919_abnormal_reproductive_system	0.94024433
72	MP0001348_abnormal_lacrimal_gland	0.93062112
73	MP0001188_hyperpigmentation	0.92135514
74	MP0003567_abnormal_fetal_cardiomyocyte	0.91797958
75	MP0009046_muscle_twitch	0.91110510
76	MP0000372_irregular_coat_pigmentation	0.89863072
77	MP0002095_abnormal_skin_pigmentation	0.89207902
78	MP0008775_abnormal_heart_ventricle	0.86470365
79	MP0002735_abnormal_chemical_nociception	0.86241501
80	MP0004742_abnormal_vestibular_system	0.85295295
81	MP0001486_abnormal_startle_reflex	0.83411691
82	MP0001873_stomach_inflammation	0.82360476
83	MP0001963_abnormal_hearing_physiology	0.82344969
84	MP0000230_abnormal_systemic_arterial	0.82340966
85	MP0003718_maternal_effect	0.81641939
86	MP0003879_abnormal_hair_cell	0.79667566
87	MP0002063_abnormal_learning/memory/cond	0.79633352
88	MP0003938_abnormal_ear_development	0.78098721
89	MP0003635_abnormal_synaptic_transmissio	0.76697483
90	MP0002210_abnormal_sex_determination	0.75345006
91	MP0003937_abnormal_limbs/digits/tail_de	0.74981212
92	MP0005645_abnormal_hypothalamus_physiol	0.74109630
93	MP0002233_abnormal_nose_morphology	0.71135473
94	MP0005253_abnormal_eye_physiology	0.70362899
95	MP0009764_decreased_sensitivity_to	0.69934976
96	MP0003942_abnormal_urinary_system	0.69847006
97	MP0002064_seizures	0.68439436
98	MP0001286_abnormal_eye_development	0.68400819
99	MP0005410_abnormal_fertilization	0.67636586
100	MP0002734_abnormal_mechanical_nocicepti	0.66515651

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.22604472
2	Abnormality of cells of the erythroid lineage (HP:0012130)	4.85998744
3	Acute necrotizing encephalopathy (HP:0006965)	4.85328196
4	Acute encephalopathy (HP:0006846)	4.19233113
5	Abnormal mitochondria in muscle tissue (HP:0008316)	4.18142998
6	Mitochondrial inheritance (HP:0001427)	4.14346681
7	Progressive macrocephaly (HP:0004481)	3.95345841
8	Macrocytic anemia (HP:0001972)	3.78958599
9	Abnormal number of erythroid precursors (HP:0012131)	3.72047155
10	Molar tooth sign on MRI (HP:0002419)	3.62738296
11	Abnormality of midbrain morphology (HP:0002418)	3.62738296
12	Pancreatic fibrosis (HP:0100732)	3.61655368
13	Increased CSF lactate (HP:0002490)	3.57240177
14	Increased hepatocellular lipid droplets (HP:0006565)	3.51965839
15	Lipid accumulation in hepatocytes (HP:0006561)	3.41390214
16	Renal Fanconi syndrome (HP:0001994)	3.25587845
17	Hepatocellular necrosis (HP:0001404)	3.24319361
18	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.23761185
19	Pancreatic cysts (HP:0001737)	3.19049269
20	Septo-optic dysplasia (HP:0100842)	3.06619633
21	Nephronophthisis (HP:0000090)	3.02796700
22	Cerebral edema (HP:0002181)	3.01781088
23	True hermaphroditism (HP:0010459)	2.96950681
24	Hepatic necrosis (HP:0002605)	2.91725217
25	Pallor (HP:0000980)	2.83550844
26	Medial flaring of the eyebrow (HP:0010747)	2.82220229
27	Abnormal rod and cone electroretinograms (HP:0008323)	2.75357324
28	Hyperglycinemia (HP:0002154)	2.70332379
29	3-Methylglutaconic aciduria (HP:0003535)	2.70227300
30	Type II lissencephaly (HP:0007260)	2.65176229
31	Pendular nystagmus (HP:0012043)	2.64302271
32	Congenital stationary night blindness (HP:0007642)	2.63566884
33	Stenosis of the external auditory canal (HP:0000402)	2.57749969
34	Abnormality of renal resorption (HP:0011038)	2.53308353
35	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.51691869
36	Optic disc pallor (HP:0000543)	2.51685255
37	Abnormality of the renal medulla (HP:0100957)	2.51473986
38	Asplenia (HP:0001746)	2.51030715
39	Increased intramyocellular lipid droplets (HP:0012240)	2.44928659
40	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.37855406
41	Sclerocornea (HP:0000647)	2.27160538
42	Lactic acidosis (HP:0003128)	2.25378605
43	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.24540864
44	Absent/shortened dynein arms (HP:0200106)	2.24540864
45	Absent thumb (HP:0009777)	2.24315956
46	Increased serum lactate (HP:0002151)	2.22254266
47	Colon cancer (HP:0003003)	2.21975821
48	Chronic hepatic failure (HP:0100626)	2.21553333
49	Gait imbalance (HP:0002141)	2.19861694
50	Exertional dyspnea (HP:0002875)	2.18567757
51	Polydipsia (HP:0001959)	2.18342549
52	Abnormal drinking behavior (HP:0030082)	2.18342549
53	Type 2 muscle fiber atrophy (HP:0003554)	2.16786258
54	Methylmalonic acidemia (HP:0002912)	2.15763542
55	Anencephaly (HP:0002323)	2.14778287
56	Myokymia (HP:0002411)	2.13652093
57	Nephrogenic diabetes insipidus (HP:0009806)	2.13644242
58	Agitation (HP:0000713)	2.13056608
59	Depressed nasal ridge (HP:0000457)	2.12589546
60	Congenital primary aphakia (HP:0007707)	2.11987443
61	Increased muscle lipid content (HP:0009058)	2.11262952
62	Respiratory difficulties (HP:0002880)	2.10216373
63	Abnormality of the renal cortex (HP:0011035)	2.08491488
64	Abnormal respiratory motile cilium morphology (HP:0005938)	2.08234443
65	Abnormal respiratory epithelium morphology (HP:0012253)	2.08234443
66	Methylmalonic aciduria (HP:0012120)	2.05383759
67	Leukodystrophy (HP:0002415)	2.05112082
68	Respiratory failure (HP:0002878)	2.02283310
69	Cystic liver disease (HP:0006706)	2.01840142
70	Optic nerve hypoplasia (HP:0000609)	1.96557690
71	Muscle fiber atrophy (HP:0100295)	1.94534335
72	Lethargy (HP:0001254)	1.93913462
73	Abnormality of alanine metabolism (HP:0010916)	1.92464750
74	Hyperalaninemia (HP:0003348)	1.92464750
75	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.92464750
76	Cerebellar dysplasia (HP:0007033)	1.92111126
77	Hyperthyroidism (HP:0000836)	1.91262951
78	Tubular atrophy (HP:0000092)	1.88538336
79	Exercise intolerance (HP:0003546)	1.88223018
80	Polyuria (HP:0000103)	1.87529257
81	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.87500530
82	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.87500530
83	Postaxial foot polydactyly (HP:0001830)	1.86416436
84	Congenital hepatic fibrosis (HP:0002612)	1.84660490
85	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.84135543
86	Absent septum pellucidum (HP:0001331)	1.83935238
87	Hypoplasia of the radius (HP:0002984)	1.82645033
88	Abolished electroretinogram (ERG) (HP:0000550)	1.81855122
89	Hypoplasia of the ulna (HP:0003022)	1.81149494
90	Glycosuria (HP:0003076)	1.80983994
91	Abnormality of urine glucose concentration (HP:0011016)	1.80983994
92	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.79608782
93	Abnormality of the labia minora (HP:0012880)	1.77485678
94	Occipital encephalocele (HP:0002085)	1.77355058
95	Maternal diabetes (HP:0009800)	1.76863339
96	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.76282887
97	Male pseudohermaphroditism (HP:0000037)	1.75535069
98	Abnormal ciliary motility (HP:0012262)	1.72973969
99	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.72553408
100	Abnormal respiratory motile cilium physiology (HP:0012261)	1.71264323

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK19	3.81242318
2	WNK4	3.25401841
3	STK16	3.06207522
4	BCKDK	2.82305484
5	NUAK1	2.82263424
6	MAP4K2	2.77597116
7	TIE1	2.62478573
8	DYRK2	2.37797409
9	ADRBK2	2.35888845
10	GRK1	2.33563383
11	TLK1	2.30372124
12	ZAK	2.17618233
13	VRK2	2.12094045
14	NME2	1.87198089
15	PINK1	1.82710588
16	TAOK3	1.76680608
17	PIK3CA	1.64982817
18	TXK	1.48024217
19	FRK	1.39162049
20	LRRK2	1.34075890
21	STK39	1.33314565
22	NME1	1.30519379
23	OXSR1	1.26279276
24	VRK1	1.23366894
25	TNIK	1.17937705
26	ARAF	1.13768296
27	PIM2	1.11933991
28	PRKCG	1.10765642
29	TYRO3	1.08278258
30	PDK2	1.07816613
31	EPHB2	1.07511371
32	CDC7	1.05224703
33	BMPR1B	1.03302285
34	TEC	1.00653521
35	PRKCQ	0.95874009
36	CASK	0.95418354
37	NTRK2	0.94887988
38	MINK1	0.93850968
39	PAK3	0.90498413
40	CSNK1G2	0.90478052
41	CAMK1	0.90115429
42	MAP3K9	0.88865217
43	MAP3K11	0.87600689
44	WNK1	0.87555864
45	BRAF	0.87446312
46	MAP2K7	0.86547492
47	KIT	0.82409147
48	INSRR	0.82220958
49	ADRBK1	0.82040175
50	RPS6KA5	0.78511115
51	MKNK1	0.75390549
52	ITK	0.75065662
53	WNK3	0.74824446
54	DAPK3	0.74628084
55	ABL2	0.74464947
56	CSNK1G3	0.73243341
57	CSNK2A2	0.73145932
58	CAMKK2	0.71693061
59	PRKCH	0.71355254
60	STK11	0.71059834
61	RPS6KA6	0.69404320
62	AURKA	0.67436641
63	PRKCI	0.67425601
64	PRKACA	0.66980726
65	FES	0.66475946
66	AURKB	0.61431325
67	LIMK1	0.61088599
68	MAP3K4	0.60845262
69	MAPKAPK5	0.60803930
70	BTK	0.59547549
71	PBK	0.58547913
72	TAF1	0.57274103
73	DYRK1B	0.56675929
74	DMPK	0.56312701
75	CSNK1E	0.55755632
76	CSNK1A1	0.53736419
77	MAP3K12	0.51546965
78	PHKG1	0.51139597
79	PHKG2	0.51139597
80	IKBKB	0.51006745
81	CSNK2A1	0.50682892
82	PLK4	0.50616568
83	RPS6KC1	0.50300562
84	RPS6KL1	0.50300562
85	CAMK1D	0.49392146
86	EPHA4	0.48336591
87	PIM1	0.48243689
88	PRKCA	0.48142715
89	CSNK1A1L	0.47732350
90	STK3	0.47186928
91	PRKCD	0.46120468
92	CAMKK1	0.45252320
93	GRK7	0.45052698
94	OBSCN	0.43650210
95	CSNK1G1	0.42716418
96	TNK2	0.40329443
97	PLK1	0.39406763
98	ATR	0.38957734
99	PLK2	0.38295996
100	CDK8	0.37952658

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.81043767
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.58894006
3	Parkinsons disease_Homo sapiens_hsa05012	3.86748140
4	Huntingtons disease_Homo sapiens_hsa05016	2.67094544
5	Alzheimers disease_Homo sapiens_hsa05010	2.62995748
6	Cardiac muscle contraction_Homo sapiens_hsa04260	2.54897894
7	Asthma_Homo sapiens_hsa05310	2.52787230
8	RNA polymerase_Homo sapiens_hsa03020	2.47821490
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.41480539
10	Proteasome_Homo sapiens_hsa03050	2.32304243
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.26174925
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.14760091
13	Homologous recombination_Homo sapiens_hsa03440	1.74048319
14	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.64425800
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.64393901
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.63711634
17	Phototransduction_Homo sapiens_hsa04744	1.62665671
18	Protein export_Homo sapiens_hsa03060	1.58268492
19	Allograft rejection_Homo sapiens_hsa05330	1.47238026
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.46630761
21	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.36778392
22	RNA degradation_Homo sapiens_hsa03018	1.34928692
23	Basal transcription factors_Homo sapiens_hsa03022	1.34189697
24	Nucleotide excision repair_Homo sapiens_hsa03420	1.29929480
25	One carbon pool by folate_Homo sapiens_hsa00670	1.28730862
26	Pyrimidine metabolism_Homo sapiens_hsa00240	1.28166601
27	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.23368114
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.18654281
29	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.15460612
30	Mismatch repair_Homo sapiens_hsa03430	1.13696051
31	Peroxisome_Homo sapiens_hsa04146	1.06728442
32	Propanoate metabolism_Homo sapiens_hsa00640	1.05444299
33	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.98961041
34	Tryptophan metabolism_Homo sapiens_hsa00380	0.91309210
35	Graft-versus-host disease_Homo sapiens_hsa05332	0.90857039
36	Purine metabolism_Homo sapiens_hsa00230	0.89727982
37	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.88620891
38	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.88247554
39	Type I diabetes mellitus_Homo sapiens_hsa04940	0.86678903
40	Sulfur relay system_Homo sapiens_hsa04122	0.86561308
41	Butanoate metabolism_Homo sapiens_hsa00650	0.86127614
42	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.85659948
43	Nicotine addiction_Homo sapiens_hsa05033	0.84978864
44	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.81328369
45	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.80284116
46	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.80149110
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.79480246
48	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.79178854
49	Nitrogen metabolism_Homo sapiens_hsa00910	0.78578474
50	Olfactory transduction_Homo sapiens_hsa04740	0.77715065
51	DNA replication_Homo sapiens_hsa03030	0.76804196
52	Metabolic pathways_Homo sapiens_hsa01100	0.75819791
53	Chemical carcinogenesis_Homo sapiens_hsa05204	0.74444603
54	Spliceosome_Homo sapiens_hsa03040	0.71751662
55	Collecting duct acid secretion_Homo sapiens_hsa04966	0.68992658
56	RNA transport_Homo sapiens_hsa03013	0.64753926
57	Base excision repair_Homo sapiens_hsa03410	0.62685754
58	Rheumatoid arthritis_Homo sapiens_hsa05323	0.61078293
59	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.60776666
60	Caffeine metabolism_Homo sapiens_hsa00232	0.59569096
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.58241120
62	Ether lipid metabolism_Homo sapiens_hsa00565	0.58109054
63	Retinol metabolism_Homo sapiens_hsa00830	0.57745178
64	Fat digestion and absorption_Homo sapiens_hsa04975	0.57040571
65	Morphine addiction_Homo sapiens_hsa05032	0.54690923
66	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.54148171
67	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.52376517
68	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.50082941
69	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.48915856
70	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.46363067
71	Fatty acid degradation_Homo sapiens_hsa00071	0.44766387
72	Pyruvate metabolism_Homo sapiens_hsa00620	0.44753335
73	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.44708278
74	Basal cell carcinoma_Homo sapiens_hsa05217	0.44528437
75	Primary immunodeficiency_Homo sapiens_hsa05340	0.44123179
76	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.42248304
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39596374
78	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.39239949
79	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.36931077
80	Glycerolipid metabolism_Homo sapiens_hsa00561	0.36194421
81	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.36065985
82	Serotonergic synapse_Homo sapiens_hsa04726	0.32991115
83	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.32348033
84	Arginine and proline metabolism_Homo sapiens_hsa00330	0.32242942
85	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.32099741
86	Regulation of autophagy_Homo sapiens_hsa04140	0.30558427
87	Steroid biosynthesis_Homo sapiens_hsa00100	0.29104421
88	Glutamatergic synapse_Homo sapiens_hsa04724	0.27993034
89	Selenocompound metabolism_Homo sapiens_hsa00450	0.27271862
90	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.26595776
91	Insulin secretion_Homo sapiens_hsa04911	0.25369131
92	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.24808602
93	Salivary secretion_Homo sapiens_hsa04970	0.23766787
94	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.23500294
95	Taste transduction_Homo sapiens_hsa04742	0.22943827
96	Tyrosine metabolism_Homo sapiens_hsa00350	0.22677217
97	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.22393341
98	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.22257699
99	Circadian entrainment_Homo sapiens_hsa04713	0.22069580
100	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.21411369

RPL6P25

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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