RPL6P27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)9.23126498
2viral transcription (GO:0019083)8.30636914
3translational termination (GO:0006415)7.85814170
4ribosomal small subunit assembly (GO:0000028)6.82368147
5translational elongation (GO:0006414)6.67641625
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.49248348
7cotranslational protein targeting to membrane (GO:0006613)6.37911540
8protein targeting to ER (GO:0045047)6.34412321
9establishment of protein localization to endoplasmic reticulum (GO:0072599)6.06172633
10cellular protein complex disassembly (GO:0043624)6.00106226
11protein localization to endoplasmic reticulum (GO:0070972)5.94736008
12viral life cycle (GO:0019058)5.89278592
13maturation of SSU-rRNA (GO:0030490)5.52896645
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.48930350
15cell proliferation in forebrain (GO:0021846)5.22972145
16ATP synthesis coupled proton transport (GO:0015986)5.13453060
17energy coupled proton transport, down electrochemical gradient (GO:0015985)5.13453060
18protein complex disassembly (GO:0043241)5.03080562
19chaperone-mediated protein transport (GO:0072321)5.00266054
20translational initiation (GO:0006413)4.72245445
21macromolecular complex disassembly (GO:0032984)4.72179933
22axon extension involved in axon guidance (GO:0048846)4.69769395
23neuron projection extension involved in neuron projection guidance (GO:1902284)4.69769395
24establishment of protein localization to mitochondrial membrane (GO:0090151)4.44207768
25protein neddylation (GO:0045116)4.39169441
26positive regulation of T cell apoptotic process (GO:0070234)4.31884019
27protein targeting to membrane (GO:0006612)4.25431545
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.25381564
29ribosomal large subunit biogenesis (GO:0042273)4.23797843
30DNA deamination (GO:0045006)4.03004702
31ribonucleoprotein complex biogenesis (GO:0022613)4.00972817
32behavioral response to nicotine (GO:0035095)3.97767643
33translation (GO:0006412)3.95311108
34negative regulation of axon extension involved in axon guidance (GO:0048843)3.94263559
35positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.84237639
36mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.83025946
37cellular component biogenesis (GO:0044085)3.78180214
38tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.72928617
39RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.72928617
40nuclear-transcribed mRNA catabolic process (GO:0000956)3.70335630
41ganglion development (GO:0061548)3.58377686
42negative regulation of axon guidance (GO:1902668)3.53052051
43positive regulation of potassium ion transmembrane transport (GO:1901381)3.51999914
44ubiquinone biosynthetic process (GO:0006744)3.48189425
45mRNA catabolic process (GO:0006402)3.46675561
46ATP biosynthetic process (GO:0006754)3.38169904
47protein complex biogenesis (GO:0070271)3.37051330
48mitochondrial respiratory chain complex I assembly (GO:0032981)3.36798412
49NADH dehydrogenase complex assembly (GO:0010257)3.36798412
50mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.36798412
51water-soluble vitamin biosynthetic process (GO:0042364)3.35827309
52facial nerve structural organization (GO:0021612)3.34123569
53respiratory electron transport chain (GO:0022904)3.30492088
54electron transport chain (GO:0022900)3.30230823
55positive regulation of lymphocyte apoptotic process (GO:0070230)3.28861478
56otic vesicle formation (GO:0030916)3.28481034
57regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.23990375
58purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.22179922
59nonmotile primary cilium assembly (GO:0035058)3.14433251
60purine nucleoside triphosphate biosynthetic process (GO:0009145)3.13652160
61ubiquinone metabolic process (GO:0006743)3.13593220
62arginine catabolic process (GO:0006527)3.12766028
63RNA catabolic process (GO:0006401)3.07649348
64motile cilium assembly (GO:0044458)3.02088667
65regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.97783335
66tongue development (GO:0043586)2.92790310
67mitochondrial respiratory chain complex assembly (GO:0033108)2.91764788
68negative regulation of appetite (GO:0032099)2.89562606
69negative regulation of response to food (GO:0032096)2.89562606
70establishment of protein localization to membrane (GO:0090150)2.82332316
71protein targeting (GO:0006605)2.80271673
72ncRNA 3-end processing (GO:0043628)2.80099875
73quinone biosynthetic process (GO:1901663)2.79387023
74pattern specification involved in kidney development (GO:0061004)2.77786349
75anterograde synaptic vesicle transport (GO:0048490)2.77785410
76positive regulation of hair follicle development (GO:0051798)2.76507110
77positive regulation of hair cycle (GO:0042635)2.76507110
78rRNA processing (GO:0006364)2.75868438
79ribonucleoside triphosphate biosynthetic process (GO:0009201)2.75064721
80DNA strand renaturation (GO:0000733)2.74655075
81negative regulation of catenin import into nucleus (GO:0035414)2.72935001
82regulation of cilium movement (GO:0003352)2.71770259
83GTP biosynthetic process (GO:0006183)2.71544979
84rRNA metabolic process (GO:0016072)2.68318865
85cytidine metabolic process (GO:0046087)2.64935774
86cytidine catabolic process (GO:0006216)2.64935774
87cytidine deamination (GO:0009972)2.64935774
88establishment of protein localization to organelle (GO:0072594)2.64916406
89negative regulation of T cell differentiation in thymus (GO:0033085)2.64754850
90transmission of nerve impulse (GO:0019226)2.64260944
91establishment of protein localization to mitochondrion (GO:0072655)2.64141332
92pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.62411957
93autophagic vacuole fusion (GO:0000046)2.55150390
94protein targeting to mitochondrion (GO:0006626)2.53979127
95cranial nerve structural organization (GO:0021604)2.51445789
96intracellular protein transmembrane import (GO:0044743)2.50013913
97negative regulation of systemic arterial blood pressure (GO:0003085)2.49031882
98sequestering of actin monomers (GO:0042989)2.48601688
99retinal ganglion cell axon guidance (GO:0031290)2.45648102
100regulation of microtubule-based movement (GO:0060632)2.44381971

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.25820700
2EZH2_22144423_ChIP-Seq_EOC_Human6.02427667
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.45313266
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.57119035
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.42549337
6BMI1_23680149_ChIP-Seq_NPCS_Mouse2.39102056
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.34653096
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.33671722
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.26980872
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.23605961
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.22283475
12EZH2_27294783_Chip-Seq_ESCs_Mouse2.19343226
13PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.06299005
14SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03711667
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.02333632
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.01210081
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.00983923
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.00894025
19CBX2_27304074_Chip-Seq_ESCs_Mouse1.97432826
20RNF2_18974828_ChIP-Seq_MESCs_Mouse1.93183978
21EZH2_18974828_ChIP-Seq_MESCs_Mouse1.93183978
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89997812
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87402094
24ERG_21242973_ChIP-ChIP_JURKAT_Human1.84446431
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79574694
26CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.79373874
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76564857
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.70700009
29RNF2_27304074_Chip-Seq_NSC_Mouse1.68732454
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.68282925
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.67688913
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.60087328
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58791959
34ZNF274_21170338_ChIP-Seq_K562_Hela1.57561655
35VDR_22108803_ChIP-Seq_LS180_Human1.57435049
36TP53_20018659_ChIP-ChIP_R1E_Mouse1.55623130
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.54702985
38SRY_22984422_ChIP-ChIP_TESTIS_Rat1.52017921
39REST_21632747_ChIP-Seq_MESCs_Mouse1.51130796
40CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.45318339
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.42091154
42CTCF_27219007_Chip-Seq_Bcells_Human1.40525080
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.40484687
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.38822405
45MYC_18940864_ChIP-ChIP_HL60_Human1.35224411
46BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.35107988
47EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.34976849
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34398357
49NANOG_20526341_ChIP-Seq_ESCs_Human1.33557888
50EST1_17652178_ChIP-ChIP_JURKAT_Human1.32028213
51RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.31484366
52ERA_21632823_ChIP-Seq_H3396_Human1.31179523
53YY1_22570637_ChIP-Seq_MALME-3M_Human1.30917866
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30543811
55KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.28674815
56CTCF_20526341_ChIP-Seq_ESCs_Human1.28659084
57REST_18959480_ChIP-ChIP_MESCs_Mouse1.24439308
58MYC_18555785_ChIP-Seq_MESCs_Mouse1.23924295
59SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.23482009
60TAF2_19829295_ChIP-Seq_ESCs_Human1.22489134
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21351849
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20656075
63CTCF_18555785_ChIP-Seq_MESCs_Mouse1.16865739
64BCL6_27268052_Chip-Seq_Bcells_Human1.14873993
65GATA3_21878914_ChIP-Seq_MCF-7_Human1.13804151
66E2F1_20622854_ChIP-Seq_HELA_Human1.12493119
67MTF2_20144788_ChIP-Seq_MESCs_Mouse1.11675189
68SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.10529535
69NCOR_22424771_ChIP-Seq_293T_Human1.07070944
70IRF1_19129219_ChIP-ChIP_H3396_Human1.06843980
71HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.06433085
72SA1_27219007_Chip-Seq_Bcells_Human1.06226168
73RING1B_27294783_Chip-Seq_ESCs_Mouse1.05487889
74AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05405559
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04520853
76XRN2_22483619_ChIP-Seq_HELA_Human1.00380016
77MYC_18358816_ChIP-ChIP_MESCs_Mouse0.99745565
78EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97682844
79FOXP1_21924763_ChIP-Seq_HESCs_Human0.97524167
80ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96102414
81CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95769292
82TTF2_22483619_ChIP-Seq_HELA_Human0.93586628
83THAP11_20581084_ChIP-Seq_MESCs_Mouse0.91545058
84ELF1_20517297_ChIP-Seq_JURKAT_Human0.91026179
85FOXH1_21741376_ChIP-Seq_ESCs_Human0.90980253
86RAC3_21632823_ChIP-Seq_H3396_Human0.90392532
87MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90308610
88FOXA1_25329375_ChIP-Seq_VCAP_Human0.90198146
89FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90198146
90PHF8_20622854_ChIP-Seq_HELA_Human0.89805720
91MYC_19829295_ChIP-Seq_ESCs_Human0.89740479
92P68_20966046_ChIP-Seq_HELA_Human0.89740390
93SOX2_21211035_ChIP-Seq_LN229_Human0.89660577
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89237976
95P53_21459846_ChIP-Seq_SAOS-2_Human0.88764580
96RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.88490438
97TDRD3_21172665_ChIP-Seq_MCF-7_Human0.86507774
98KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.85494968
99SRF_21415370_ChIP-Seq_HL-1_Mouse0.84964608
100NOTCH1_21737748_ChIP-Seq_TLL_Human0.84701643

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode5.36678045
2MP0009379_abnormal_foot_pigmentation3.90369932
3MP0002163_abnormal_gland_morphology3.29404172
4MP0008789_abnormal_olfactory_epithelium2.91961634
5MP0003136_yellow_coat_color2.89983762
6MP0002837_dystrophic_cardiac_calcinosis2.82654353
7MP0000566_synostosis2.68896053
8MP0003646_muscle_fatigue2.56376757
9MP0002653_abnormal_ependyma_morphology2.39430478
10MP0005394_taste/olfaction_phenotype2.38982748
11MP0005499_abnormal_olfactory_system2.38982748
12MP0001986_abnormal_taste_sensitivity2.15428872
13MP0004142_abnormal_muscle_tone2.10959437
14MP0002938_white_spotting2.00498570
15MP0005084_abnormal_gallbladder_morpholo1.94908587
16MP0004145_abnormal_muscle_electrophysio1.94230317
17MP0000049_abnormal_middle_ear1.79486843
18MP0002160_abnormal_reproductive_system1.73176895
19MP0003879_abnormal_hair_cell1.72969943
20MP0005379_endocrine/exocrine_gland_phen1.71383880
21MP0005377_hearing/vestibular/ear_phenot1.70060245
22MP0003878_abnormal_ear_physiology1.70060245
23MP0002102_abnormal_ear_morphology1.65114382
24MP0006276_abnormal_autonomic_nervous1.62286011
25MP0002638_abnormal_pupillary_reflex1.61515951
26MP0005646_abnormal_pituitary_gland1.60673441
27MP0000778_abnormal_nervous_system1.55974579
28MP0005551_abnormal_eye_electrophysiolog1.54165495
29MP0001485_abnormal_pinna_reflex1.49814499
30MP0004742_abnormal_vestibular_system1.48863779
31MP0001188_hyperpigmentation1.45796473
32MP0002277_abnormal_respiratory_mucosa1.44841759
33MP0001293_anophthalmia1.44721414
34MP0000631_abnormal_neuroendocrine_gland1.44682547
35MP0009053_abnormal_anal_canal1.41439405
36MP0005389_reproductive_system_phenotype1.41340927
37MP0004885_abnormal_endolymph1.41288292
38MP0006072_abnormal_retinal_apoptosis1.39612285
39MP0004133_heterotaxia1.39345856
40MP0005645_abnormal_hypothalamus_physiol1.37327913
41MP0002095_abnormal_skin_pigmentation1.37004429
42MP0002249_abnormal_larynx_morphology1.36603822
43MP0003121_genomic_imprinting1.35104857
44MP0010030_abnormal_orbit_morphology1.33468702
45MP0002733_abnormal_thermal_nociception1.31623838
46MP0005671_abnormal_response_to1.31400029
47MP0005410_abnormal_fertilization1.25751602
48MP0003122_maternal_imprinting1.24463961
49MP0009250_abnormal_appendicular_skeleto1.23908646
50MP0002272_abnormal_nervous_system1.23119989
51MP0001968_abnormal_touch/_nociception1.22992898
52MP0000569_abnormal_digit_pigmentation1.22546462
53MP0005423_abnormal_somatic_nervous1.22061770
54MP0002184_abnormal_innervation1.18300427
55MP0002557_abnormal_social/conspecific_i1.17949753
56MP0000026_abnormal_inner_ear1.13243040
57MP0009745_abnormal_behavioral_response1.10783080
58MP0001970_abnormal_pain_threshold1.10509037
59MP0001905_abnormal_dopamine_level1.09359125
60MP0005174_abnormal_tail_pigmentation1.06510757
61MP0000579_abnormal_nail_morphology1.05274288
62MP0008872_abnormal_physiological_respon1.04151084
63MP0009333_abnormal_splenocyte_physiolog1.01111955
64MP0002752_abnormal_somatic_nervous0.99756508
65MP0001919_abnormal_reproductive_system0.99496276
66MP0003880_abnormal_central_pattern0.99493413
67MP0004130_abnormal_muscle_cell0.99428499
68MP0003195_calcinosis0.99055604
69MP0000678_abnormal_parathyroid_gland0.96328674
70MP0004858_abnormal_nervous_system0.96260149
71MP0003011_delayed_dark_adaptation0.95411033
72MP0003635_abnormal_synaptic_transmissio0.95320413
73MP0005195_abnormal_posterior_eye0.94716018
74MP0002735_abnormal_chemical_nociception0.94559744
75MP0002734_abnormal_mechanical_nocicepti0.94491338
76MP0001963_abnormal_hearing_physiology0.94439167
77MP0002063_abnormal_learning/memory/cond0.94249483
78MP0004147_increased_porphyrin_level0.94085364
79MP0008775_abnormal_heart_ventricle0.93890151
80MP0009046_muscle_twitch0.91421163
81MP0002736_abnormal_nociception_after0.89320084
82MP0002572_abnormal_emotion/affect_behav0.88981472
83MP0001440_abnormal_grooming_behavior0.86149722
84MP0003567_abnormal_fetal_cardiomyocyte0.85133134
85MP0001529_abnormal_vocalization0.84937751
86MP0003186_abnormal_redox_activity0.80181462
87MP0002234_abnormal_pharynx_morphology0.80015910
88MP0003938_abnormal_ear_development0.79940364
89MP0002138_abnormal_hepatobiliary_system0.76990795
90MP0001984_abnormal_olfaction0.76374403
91MP0003123_paternal_imprinting0.75227325
92MP0000955_abnormal_spinal_cord0.74031169
93MP0002876_abnormal_thyroid_physiology0.70607460
94MP0000372_irregular_coat_pigmentation0.69199609
95MP0002210_abnormal_sex_determination0.68352061
96MP0005386_behavior/neurological_phenoty0.68190218
97MP0004924_abnormal_behavior0.68190218
98MP0001348_abnormal_lacrimal_gland0.67318464
99MP0003315_abnormal_perineum_morphology0.66256511
100MP0003937_abnormal_limbs/digits/tail_de0.66120849

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.16931464
2Abnormal number of erythroid precursors (HP:0012131)4.59413160
3Absent/shortened dynein arms (HP:0200106)4.11292076
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.11292076
5Reticulocytopenia (HP:0001896)3.92397925
6Absent rod-and cone-mediated responses on ERG (HP:0007688)3.81752691
7Rib fusion (HP:0000902)3.71904044
8Macrocytic anemia (HP:0001972)3.62337303
9Abnormal rod and cone electroretinograms (HP:0008323)3.56129570
10Abnormal respiratory epithelium morphology (HP:0012253)3.55359661
11Abnormal respiratory motile cilium morphology (HP:0005938)3.55359661
12Congenital stationary night blindness (HP:0007642)3.50583017
13Acute necrotizing encephalopathy (HP:0006965)3.46278428
14Nephronophthisis (HP:0000090)3.43765438
15Chronic otitis media (HP:0000389)3.39220043
16Chronic sinusitis (HP:0011109)3.37005466
17True hermaphroditism (HP:0010459)3.25804322
18Pancreatic fibrosis (HP:0100732)3.17421042
19Abnormal ciliary motility (HP:0012262)3.13901506
20Mitochondrial inheritance (HP:0001427)3.13512659
21Abnormal mitochondria in muscle tissue (HP:0008316)3.07095109
22Acute encephalopathy (HP:0006846)3.02692737
23Abnormal number of incisors (HP:0011064)3.02483333
24Pancreatic cysts (HP:0001737)3.00985716
25Hyperglycinemia (HP:0002154)3.00952582
26Severe visual impairment (HP:0001141)2.96572781
27Abnormality of midbrain morphology (HP:0002418)2.84387561
28Molar tooth sign on MRI (HP:0002419)2.84387561
29Pendular nystagmus (HP:0012043)2.82049608
30Sclerocornea (HP:0000647)2.78002996
31Medial flaring of the eyebrow (HP:0010747)2.74973994
32Pallor (HP:0000980)2.74933786
33Gait imbalance (HP:0002141)2.71808727
34Progressive macrocephaly (HP:0004481)2.68618882
35Chronic hepatic failure (HP:0100626)2.65408757
36Abnormal respiratory motile cilium physiology (HP:0012261)2.64884483
37Congenital primary aphakia (HP:0007707)2.59883330
38Increased CSF lactate (HP:0002490)2.57869723
39Agitation (HP:0000713)2.57073918
40Impulsivity (HP:0100710)2.55867268
41Septo-optic dysplasia (HP:0100842)2.53604019
42Abnormality of the renal medulla (HP:0100957)2.46141757
433-Methylglutaconic aciduria (HP:0003535)2.36683896
44Abnormality of the aortic arch (HP:0012303)2.35394789
45Abnormality of the 4th metacarpal (HP:0010012)2.35342747
46Nephrogenic diabetes insipidus (HP:0009806)2.31140103
47Microretrognathia (HP:0000308)2.23483803
48Bony spicule pigmentary retinopathy (HP:0007737)2.10578192
49Decreased electroretinogram (ERG) amplitude (HP:0000654)2.10168993
50Abolished electroretinogram (ERG) (HP:0000550)2.06614719
51Increased hepatocellular lipid droplets (HP:0006565)2.04487443
52Anencephaly (HP:0002323)2.03824184
53Aplasia/Hypoplasia of the tongue (HP:0010295)2.03009795
54Abnormality of macular pigmentation (HP:0008002)2.02714193
55Restlessness (HP:0000711)2.02694684
56Type II lissencephaly (HP:0007260)2.02122739
57Attenuation of retinal blood vessels (HP:0007843)2.01890180
58Cerebral edema (HP:0002181)2.00249012
59Increased intramyocellular lipid droplets (HP:0012240)2.00194245
60Optic disc pallor (HP:0000543)1.99758027
61Short 4th metacarpal (HP:0010044)1.99664198
62Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.99664198
63Vaginal atresia (HP:0000148)1.98548832
64Concave nail (HP:0001598)1.96487490
65Cystic liver disease (HP:0006706)1.96265854
66Hyperthyroidism (HP:0000836)1.93174717
67Myokymia (HP:0002411)1.93077319
68Decreased central vision (HP:0007663)1.92298330
69Abnormality of the phalanges of the 2nd finger (HP:0009541)1.90545694
70Short femoral neck (HP:0100864)1.90361171
71Esophageal atresia (HP:0002032)1.89844594
72Male pseudohermaphroditism (HP:0000037)1.89725753
73Hepatocellular necrosis (HP:0001404)1.89598675
74Genital tract atresia (HP:0001827)1.89555710
75Lipid accumulation in hepatocytes (HP:0006561)1.89154312
76Adrenal hypoplasia (HP:0000835)1.88926734
77Maternal diabetes (HP:0009800)1.85859839
78Abnormality of renal resorption (HP:0011038)1.85580288
79Poor coordination (HP:0002370)1.85539301
80Increased serum lactate (HP:0002151)1.84364460
81Postaxial foot polydactyly (HP:0001830)1.83378715
82Elevated erythrocyte sedimentation rate (HP:0003565)1.83335091
83Constricted visual fields (HP:0001133)1.82874821
84Aplasia/Hypoplasia of the spleen (HP:0010451)1.82743092
85Renal dysplasia (HP:0000110)1.82666087
86Renal Fanconi syndrome (HP:0001994)1.80979077
87Asplenia (HP:0001746)1.80816634
88Holoprosencephaly (HP:0001360)1.80510693
89Preaxial hand polydactyly (HP:0001177)1.80077527
90Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78525978
91Polyphagia (HP:0002591)1.78476140
92Abnormality of the labia minora (HP:0012880)1.77998094
93Depressed nasal ridge (HP:0000457)1.77635269
94Retinitis pigmentosa (HP:0000510)1.74696057
95Increased corneal curvature (HP:0100692)1.74504016
96Keratoconus (HP:0000563)1.74504016
97Hypoplasia of the uterus (HP:0000013)1.74180713
98Tachypnea (HP:0002789)1.73612864
99Nasal polyposis (HP:0100582)1.72075026
100Tubular atrophy (HP:0000092)1.71205351

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK3.40196194
2TXK2.96001597
3STK162.80068671
4TYRO32.67424677
5NTRK22.39164395
6NUAK12.25857364
7ZAK2.14310192
8CAMKK12.07069264
9GRK12.07012128
10ADRBK22.03986920
11WNK42.03771503
12DYRK22.00666808
13MAP4K11.99487100
14FGFR21.92263334
15MAP3K111.86269958
16LRRK21.80257546
17WNK31.78568707
18MAP3K131.75217266
19BCKDK1.74637316
20LIMK11.68402227
21GRK71.64839643
22KDR1.54342562
23CDC71.51013393
24CAMKK21.46706073
25EPHB21.39111060
26CDK191.38918194
27TIE11.36653515
28MAP3K91.36601196
29VRK21.27502979
30TLK11.25165111
31MAP2K71.24865364
32ARAF1.24395346
33PRKD31.24030628
34NME21.23342852
35TEC1.22508567
36KIT1.19447176
37PDK21.13573473
38PINK11.11589452
39TNK21.10388323
40PRKCQ1.09493685
41ITK1.03924324
42MOS1.03093734
43ABL21.02374543
44ADRBK11.00772442
45PRKCG0.98650216
46FRK0.97407452
47AURKA0.95927738
48BRAF0.94134085
49SIK20.90082369
50MAPK130.89543457
51STK390.86580536
52RPS6KA60.85459851
53CAMK10.85282525
54INSRR0.84341803
55SYK0.83282707
56VRK10.79837875
57TESK20.78105529
58GRK50.76686045
59BMPR1B0.73329621
60MAP3K40.71514528
61PRKACA0.71465993
62DYRK30.71298732
63TAF10.71175271
64DAPK30.70753847
65OBSCN0.66548867
66RPS6KC10.65902701
67RPS6KL10.65902701
68PRKCI0.59965235
69BRSK10.59418792
70MAP4K20.59178158
71RPS6KA50.58646639
72MAPK150.58524249
73STK110.58423979
74TNIK0.57906131
75LCK0.56702778
76MAP2K60.54637471
77RPS6KA20.54635368
78PRKCD0.53395392
79MARK10.53125098
80NEK20.52319519
81PAK10.51551009
82BTK0.50291863
83CSNK2A20.49815035
84DMPK0.48881498
85RPS6KB20.48659099
86PRKCZ0.48298955
87PRKCA0.47012969
88MUSK0.46904493
89CASK0.46903028
90PIM20.44642469
91PIM10.44278691
92EPHA40.43304034
93NTRK10.42572516
94IKBKB0.42363544
95DAPK20.39831265
96PRKCH0.39511012
97PAK30.37642105
98BUB10.34277175
99CSNK2A10.33344157
100CSNK1E0.32431794

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.56470831
2Oxidative phosphorylation_Homo sapiens_hsa001904.05620719
3Parkinsons disease_Homo sapiens_hsa050123.42495489
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.21114039
5Cardiac muscle contraction_Homo sapiens_hsa042602.56770624
6Alzheimers disease_Homo sapiens_hsa050102.42222126
7Phototransduction_Homo sapiens_hsa047442.41129322
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.36277292
9Huntingtons disease_Homo sapiens_hsa050162.32553952
10Sulfur relay system_Homo sapiens_hsa041222.15922266
11Linoleic acid metabolism_Homo sapiens_hsa005912.06282890
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.06082899
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.95245629
14Primary immunodeficiency_Homo sapiens_hsa053401.73171931
15RNA polymerase_Homo sapiens_hsa030201.69645893
16Nicotine addiction_Homo sapiens_hsa050331.51897381
17Basal cell carcinoma_Homo sapiens_hsa052171.37110533
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29591550
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28743111
20Olfactory transduction_Homo sapiens_hsa047401.26468378
21Sulfur metabolism_Homo sapiens_hsa009201.24426313
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22832041
23Proteasome_Homo sapiens_hsa030501.04181589
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03341625
25Hedgehog signaling pathway_Homo sapiens_hsa043401.02997382
26Homologous recombination_Homo sapiens_hsa034401.02901454
27Arachidonic acid metabolism_Homo sapiens_hsa005901.01737614
28Nitrogen metabolism_Homo sapiens_hsa009101.01362163
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98140191
30Pyrimidine metabolism_Homo sapiens_hsa002400.95237867
31Fat digestion and absorption_Homo sapiens_hsa049750.94100717
32Chemical carcinogenesis_Homo sapiens_hsa052040.90637871
33One carbon pool by folate_Homo sapiens_hsa006700.89730792
34Steroid hormone biosynthesis_Homo sapiens_hsa001400.87193215
35Tyrosine metabolism_Homo sapiens_hsa003500.87191895
36Protein export_Homo sapiens_hsa030600.86139562
37Steroid biosynthesis_Homo sapiens_hsa001000.84265510
38Retinol metabolism_Homo sapiens_hsa008300.83491929
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79653948
40Morphine addiction_Homo sapiens_hsa050320.79043251
41RNA degradation_Homo sapiens_hsa030180.75906961
42Graft-versus-host disease_Homo sapiens_hsa053320.75787907
43Taste transduction_Homo sapiens_hsa047420.74003263
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73702206
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73527048
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73067906
47Maturity onset diabetes of the young_Homo sapiens_hsa049500.72434299
48Basal transcription factors_Homo sapiens_hsa030220.72329202
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71039531
50Peroxisome_Homo sapiens_hsa041460.70424398
51Ether lipid metabolism_Homo sapiens_hsa005650.69370615
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68595188
53DNA replication_Homo sapiens_hsa030300.67563248
54Metabolic pathways_Homo sapiens_hsa011000.67254193
55Intestinal immune network for IgA production_Homo sapiens_hsa046720.66373093
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64780641
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.64191366
58Autoimmune thyroid disease_Homo sapiens_hsa053200.63628020
59Cocaine addiction_Homo sapiens_hsa050300.63327252
60Axon guidance_Homo sapiens_hsa043600.62817835
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61997937
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61959455
63beta-Alanine metabolism_Homo sapiens_hsa004100.61378514
64Purine metabolism_Homo sapiens_hsa002300.61207202
65Insulin secretion_Homo sapiens_hsa049110.58902579
66Regulation of autophagy_Homo sapiens_hsa041400.58820247
67Tryptophan metabolism_Homo sapiens_hsa003800.58612376
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58121279
69Asthma_Homo sapiens_hsa053100.56937222
70Ovarian steroidogenesis_Homo sapiens_hsa049130.55583516
71Allograft rejection_Homo sapiens_hsa053300.54846769
72Fanconi anemia pathway_Homo sapiens_hsa034600.52995855
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.52752670
74Antigen processing and presentation_Homo sapiens_hsa046120.52106764
75ABC transporters_Homo sapiens_hsa020100.50471426
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50083887
77Serotonergic synapse_Homo sapiens_hsa047260.48548244
78Glycerolipid metabolism_Homo sapiens_hsa005610.48193523
79Butanoate metabolism_Homo sapiens_hsa006500.46787860
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46725559
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46196240
82Fatty acid degradation_Homo sapiens_hsa000710.45400632
83Selenocompound metabolism_Homo sapiens_hsa004500.45159773
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41845603
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38895072
86Base excision repair_Homo sapiens_hsa034100.37222840
87Propanoate metabolism_Homo sapiens_hsa006400.37029699
88Nucleotide excision repair_Homo sapiens_hsa034200.36266377
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35589980
90Hematopoietic cell lineage_Homo sapiens_hsa046400.34273116
91GABAergic synapse_Homo sapiens_hsa047270.34078231
92Caffeine metabolism_Homo sapiens_hsa002320.33786600
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32258033
94Mismatch repair_Homo sapiens_hsa034300.32093595
95Type I diabetes mellitus_Homo sapiens_hsa049400.30226505
96Rheumatoid arthritis_Homo sapiens_hsa053230.28703121
97Glutathione metabolism_Homo sapiens_hsa004800.28126359
98Systemic lupus erythematosus_Homo sapiens_hsa053220.27884166
99Arginine and proline metabolism_Homo sapiens_hsa003300.27253365
100Alcoholism_Homo sapiens_hsa050340.26076254

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