RPL6P30

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)8.98014188
2ribosomal small subunit assembly (GO:0000028)8.78527496
3translational termination (GO:0006415)8.59054045
4ribosomal small subunit biogenesis (GO:0042274)7.89586630
5maturation of SSU-rRNA (GO:0030490)7.80871981
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.31712649
7cotranslational protein targeting to membrane (GO:0006613)7.25721587
8translational elongation (GO:0006414)7.23300104
9protein targeting to ER (GO:0045047)7.19502406
10establishment of protein localization to endoplasmic reticulum (GO:0072599)6.90120718
11protein localization to endoplasmic reticulum (GO:0070972)6.75941625
12cellular protein complex disassembly (GO:0043624)6.60196172
13viral life cycle (GO:0019058)6.38724589
14energy coupled proton transport, down electrochemical gradient (GO:0015985)6.35820974
15ATP synthesis coupled proton transport (GO:0015986)6.35820974
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.35725775
17chaperone-mediated protein transport (GO:0072321)6.26487633
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.06555638
19translational initiation (GO:0006413)5.72463109
20protein complex disassembly (GO:0043241)5.64312688
21establishment of protein localization to mitochondrial membrane (GO:0090151)5.56662258
22macromolecular complex disassembly (GO:0032984)5.35391284
23behavioral response to nicotine (GO:0035095)5.04232191
24protein targeting to membrane (GO:0006612)4.91287364
25ribosomal large subunit biogenesis (GO:0042273)4.71197122
26nuclear-transcribed mRNA catabolic process (GO:0000956)4.54774763
27translation (GO:0006412)4.52768140
28mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.44784649
29protein neddylation (GO:0045116)4.40663641
30mitochondrial respiratory chain complex I assembly (GO:0032981)4.35287933
31NADH dehydrogenase complex assembly (GO:0010257)4.35287933
32mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.35287933
33respiratory electron transport chain (GO:0022904)4.35068352
34mRNA catabolic process (GO:0006402)4.33593106
35electron transport chain (GO:0022900)4.30551491
36protein complex biogenesis (GO:0070271)4.15903364
37RNA catabolic process (GO:0006401)3.88111305
38substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.87254371
39substrate-independent telencephalic tangential migration (GO:0021826)3.87254371
40GTP biosynthetic process (GO:0006183)3.84744235
41mitochondrial respiratory chain complex assembly (GO:0033108)3.82980619
42ribonucleoprotein complex biogenesis (GO:0022613)3.80784671
43cellular component biogenesis (GO:0044085)3.74727076
44purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.73024938
45nonmotile primary cilium assembly (GO:0035058)3.71543496
46ATP biosynthetic process (GO:0006754)3.69324108
47purine nucleoside triphosphate biosynthetic process (GO:0009145)3.68539890
48water-soluble vitamin biosynthetic process (GO:0042364)3.50407885
49neuron fate determination (GO:0048664)3.42340463
50establishment of protein localization to membrane (GO:0090150)3.39517892
51hydrogen ion transmembrane transport (GO:1902600)3.38917261
52UTP biosynthetic process (GO:0006228)3.34034042
53somite development (GO:0061053)3.30051043
54ribonucleoside triphosphate biosynthetic process (GO:0009201)3.25641715
55protein targeting (GO:0006605)3.24843092
56epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.20569171
57nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.19616819
58UTP metabolic process (GO:0046051)3.06649947
59establishment of protein localization to organelle (GO:0072594)3.05382104
60proton transport (GO:0015992)3.05320847
61exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.03480058
62hydrogen transport (GO:0006818)2.99611595
63rRNA processing (GO:0006364)2.95771783
64transcription elongation from RNA polymerase III promoter (GO:0006385)2.92957458
65termination of RNA polymerase III transcription (GO:0006386)2.92957458
66rRNA metabolic process (GO:0016072)2.90479363
67cell proliferation in forebrain (GO:0021846)2.90380712
68tongue development (GO:0043586)2.89038777
69epithelial cilium movement (GO:0003351)2.84015381
70nucleoside triphosphate biosynthetic process (GO:0009142)2.83798231
71intracellular protein transmembrane import (GO:0044743)2.80994273
72negative regulation of appetite (GO:0032099)2.72881637
73negative regulation of response to food (GO:0032096)2.72881637
74protein localization to membrane (GO:0072657)2.71412887
75RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.70445888
76tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.70445888
77thalamus development (GO:0021794)2.68270539
78pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.68252652
79DNA deamination (GO:0045006)2.66996743
80axonemal dynein complex assembly (GO:0070286)2.66944363
81regulation of microtubule-based movement (GO:0060632)2.66437913
82CTP biosynthetic process (GO:0006241)2.63300482
83CTP metabolic process (GO:0046036)2.63300482
84intraciliary transport (GO:0042073)2.62784816
85inner mitochondrial membrane organization (GO:0007007)2.62633358
86rRNA modification (GO:0000154)2.60514577
87regulation of cilium movement (GO:0003352)2.60224562
88negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.57965722
89synaptic transmission, cholinergic (GO:0007271)2.57008488
90pyrimidine nucleobase catabolic process (GO:0006208)2.56742971
91establishment of protein localization to mitochondrion (GO:0072655)2.56434570
92positive regulation of respiratory burst (GO:0060267)2.54067183
93protein targeting to mitochondrion (GO:0006626)2.51826987
94limb development (GO:0060173)2.51037517
95appendage development (GO:0048736)2.51037517
96respiratory chain complex IV assembly (GO:0008535)2.49066621
97negative regulation of telomere maintenance (GO:0032205)2.48348036
98pattern specification involved in kidney development (GO:0061004)2.47860403
99segment specification (GO:0007379)2.44997753
100nucleoside diphosphate phosphorylation (GO:0006165)2.43944419

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.52478725
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.97629652
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.36163212
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.27970135
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.22461760
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.05333227
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.78355966
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.50981093
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.41992193
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39338013
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.34553378
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.13478297
13CBX2_27304074_Chip-Seq_ESCs_Mouse2.12040883
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.01477903
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.97240644
16TTF2_22483619_ChIP-Seq_HELA_Human1.95303902
17TP63_19390658_ChIP-ChIP_HaCaT_Human1.91589681
18EZH2_27304074_Chip-Seq_ESCs_Mouse1.89477500
19ZNF274_21170338_ChIP-Seq_K562_Hela1.89058066
20VDR_22108803_ChIP-Seq_LS180_Human1.88829091
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.85595937
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.82369950
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.79961957
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.79522396
25VDR_23849224_ChIP-Seq_CD4+_Human1.70640172
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.68056912
27XRN2_22483619_ChIP-Seq_HELA_Human1.66297359
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.65767395
29MYC_18940864_ChIP-ChIP_HL60_Human1.65109609
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.64157454
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61782798
32ELK1_19687146_ChIP-ChIP_HELA_Human1.61249040
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.56153132
34FOXP3_21729870_ChIP-Seq_TREG_Human1.53041884
35EWS_26573619_Chip-Seq_HEK293_Human1.50613922
36CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.48190461
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.46615309
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.43946153
39TP53_22573176_ChIP-Seq_HFKS_Human1.43186792
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.42788192
41RNF2_27304074_Chip-Seq_NSC_Mouse1.40976717
42KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.40419476
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37533377
44REST_21632747_ChIP-Seq_MESCs_Mouse1.37258005
45IRF1_19129219_ChIP-ChIP_H3396_Human1.36836654
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34680100
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34060784
48SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.32470505
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28462367
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.27965983
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27728777
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.26869234
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25794133
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24778610
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24499029
56FUS_26573619_Chip-Seq_HEK293_Human1.24239435
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22986006
58SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.21630078
59IGF1R_20145208_ChIP-Seq_DFB_Human1.21274668
60RNF2_27304074_Chip-Seq_ESCs_Mouse1.18433260
61ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18063911
62GABP_19822575_ChIP-Seq_HepG2_Human1.14330400
63EZH2_18974828_ChIP-Seq_MESCs_Mouse1.13292738
64RNF2_18974828_ChIP-Seq_MESCs_Mouse1.13292738
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13086572
66TP53_20018659_ChIP-ChIP_R1E_Mouse1.12928956
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11874322
68MYC_19030024_ChIP-ChIP_MESCs_Mouse1.11572830
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09842775
70SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.07726625
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07001634
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06406456
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05582013
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.05324307
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04619547
76SOX2_16153702_ChIP-ChIP_HESCs_Human1.02883644
77NCOR_22424771_ChIP-Seq_293T_Human1.00522232
78ERA_21632823_ChIP-Seq_H3396_Human1.00068746
79REST_18959480_ChIP-ChIP_MESCs_Mouse0.99963859
80P300_19829295_ChIP-Seq_ESCs_Human0.97417652
81TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96533478
82MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95992980
83SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94575203
84ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94280066
85GBX2_23144817_ChIP-Seq_PC3_Human0.94125098
86GATA1_26923725_Chip-Seq_HPCs_Mouse0.93726641
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92291869
88PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91849530
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90900183
90CTCF_18555785_ChIP-Seq_MESCs_Mouse0.90882149
91RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90654155
92SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.90015775
93CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.89990525
94ELK1_22589737_ChIP-Seq_MCF10A_Human0.89925483
95SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.89432418
96PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89220813
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87952190
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87952190
99TAF2_19829295_ChIP-Seq_ESCs_Human0.87916139
100FLI1_27457419_Chip-Seq_LIVER_Mouse0.87407375

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.44578130
2MP0006292_abnormal_olfactory_placode4.00599394
3MP0003122_maternal_imprinting2.56262802
4MP0003136_yellow_coat_color2.54935365
5MP0004142_abnormal_muscle_tone2.45687026
6MP0008789_abnormal_olfactory_epithelium2.42533537
7MP0010030_abnormal_orbit_morphology2.38229810
8MP0003787_abnormal_imprinting2.29783464
9MP0002102_abnormal_ear_morphology2.19975926
10MP0003646_muscle_fatigue2.11883676
11MP0005499_abnormal_olfactory_system2.09284428
12MP0005394_taste/olfaction_phenotype2.09284428
13MP0001529_abnormal_vocalization2.05136380
14MP0001293_anophthalmia1.97897705
15MP0002938_white_spotting1.94860513
16MP0002163_abnormal_gland_morphology1.94128631
17MP0002837_dystrophic_cardiac_calcinosis1.88553430
18MP0008877_abnormal_DNA_methylation1.87645215
19MP0000049_abnormal_middle_ear1.82515934
20MP0000778_abnormal_nervous_system1.79882364
21MP0006072_abnormal_retinal_apoptosis1.79089828
22MP0003121_genomic_imprinting1.70356652
23MP0001485_abnormal_pinna_reflex1.68388945
24MP0006276_abnormal_autonomic_nervous1.65579847
25MP0004742_abnormal_vestibular_system1.64086875
26MP0002653_abnormal_ependyma_morphology1.62366059
27MP0004885_abnormal_endolymph1.60573806
28MP0000566_synostosis1.56009263
29MP0005084_abnormal_gallbladder_morpholo1.54318872
30MP0005551_abnormal_eye_electrophysiolog1.52642661
31MP0000631_abnormal_neuroendocrine_gland1.51998268
32MP0002638_abnormal_pupillary_reflex1.47843507
33MP0005646_abnormal_pituitary_gland1.47692259
34MP0003283_abnormal_digestive_organ1.42848586
35MP0003011_delayed_dark_adaptation1.39800854
36MP0001984_abnormal_olfaction1.39790753
37MP0009053_abnormal_anal_canal1.39300085
38MP0005377_hearing/vestibular/ear_phenot1.39197088
39MP0003878_abnormal_ear_physiology1.39197088
40MP0002272_abnormal_nervous_system1.38636434
41MP0002160_abnormal_reproductive_system1.38379510
42MP0005423_abnormal_somatic_nervous1.36874649
43MP0005379_endocrine/exocrine_gland_phen1.36154186
44MP0001348_abnormal_lacrimal_gland1.33498340
45MP0003123_paternal_imprinting1.29916834
46MP0002736_abnormal_nociception_after1.27028399
47MP0001968_abnormal_touch/_nociception1.26042503
48MP0003938_abnormal_ear_development1.25047897
49MP0003880_abnormal_central_pattern1.24136551
50MP0001440_abnormal_grooming_behavior1.23205006
51MP0008872_abnormal_physiological_respon1.20990291
52MP0001905_abnormal_dopamine_level1.18527817
53MP0002557_abnormal_social/conspecific_i1.15598491
54MP0002277_abnormal_respiratory_mucosa1.14503305
55MP0003937_abnormal_limbs/digits/tail_de1.14410052
56MP0002234_abnormal_pharynx_morphology1.13904173
57MP0004133_heterotaxia1.13520022
58MP0000026_abnormal_inner_ear1.12228869
59MP0005389_reproductive_system_phenotype1.09476815
60MP0005195_abnormal_posterior_eye1.09309351
61MP0003567_abnormal_fetal_cardiomyocyte1.08870541
62MP0004145_abnormal_muscle_electrophysio1.08631901
63MP0005253_abnormal_eye_physiology1.08369597
64MP0009745_abnormal_behavioral_response1.01619966
65MP0002233_abnormal_nose_morphology1.01394584
66MP0001970_abnormal_pain_threshold1.01058597
67MP0000955_abnormal_spinal_cord0.99067643
68MP0003119_abnormal_digestive_system0.98401737
69MP0002095_abnormal_skin_pigmentation0.98281539
70MP0002752_abnormal_somatic_nervous0.97632402
71MP0003186_abnormal_redox_activity0.96951715
72MP0002572_abnormal_emotion/affect_behav0.96323332
73MP0002733_abnormal_thermal_nociception0.96323096
74MP0001486_abnormal_startle_reflex0.96014522
75MP0002184_abnormal_innervation0.95216491
76MP0001986_abnormal_taste_sensitivity0.94827272
77MP0002734_abnormal_mechanical_nocicepti0.93101271
78MP0002735_abnormal_chemical_nociception0.90486005
79MP0003635_abnormal_synaptic_transmissio0.88555710
80MP0001286_abnormal_eye_development0.86119968
81MP0002063_abnormal_learning/memory/cond0.86065474
82MP0002210_abnormal_sex_determination0.82450148
83MP0002067_abnormal_sensory_capabilities0.82399361
84MP0009046_muscle_twitch0.81758301
85MP0008995_early_reproductive_senescence0.81002889
86MP0002064_seizures0.79854296
87MP0001963_abnormal_hearing_physiology0.78697649
88MP0008775_abnormal_heart_ventricle0.78346904
89MP0005391_vision/eye_phenotype0.78333093
90MP0002282_abnormal_trachea_morphology0.78241756
91MP0004019_abnormal_vitamin_homeostasis0.76772401
92MP0005645_abnormal_hypothalamus_physiol0.75496350
93MP0002249_abnormal_larynx_morphology0.74627689
94MP0002138_abnormal_hepatobiliary_system0.73857588
95MP0001502_abnormal_circadian_rhythm0.73199397
96MP0002876_abnormal_thyroid_physiology0.68924294
97MP0003942_abnormal_urinary_system0.68909279
98MP0002928_abnormal_bile_duct0.68751346
99MP0008875_abnormal_xenobiotic_pharmacok0.68324591
100MP0002152_abnormal_brain_morphology0.68156091

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)6.48101647
2Abnormality of cells of the erythroid lineage (HP:0012130)5.45839480
3Abnormal number of erythroid precursors (HP:0012131)4.60378257
4Macrocytic anemia (HP:0001972)4.49295930
5Acute necrotizing encephalopathy (HP:0006965)4.32472425
6Increased hepatocellular lipid droplets (HP:0006565)4.04292647
7Mitochondrial inheritance (HP:0001427)4.01215072
8Abnormality of midbrain morphology (HP:0002418)3.82624101
9Molar tooth sign on MRI (HP:0002419)3.82624101
10Abnormal mitochondria in muscle tissue (HP:0008316)3.73952622
11Acute encephalopathy (HP:0006846)3.71399419
12Lipid accumulation in hepatocytes (HP:0006561)3.69148550
13Septo-optic dysplasia (HP:0100842)3.58086607
14Increased CSF lactate (HP:0002490)3.56701342
15Progressive macrocephaly (HP:0004481)3.54064336
16Pancreatic fibrosis (HP:0100732)3.33126334
17Pallor (HP:0000980)3.27508815
18Hepatocellular necrosis (HP:0001404)3.24726068
19Rib fusion (HP:0000902)3.21380670
20Aplasia/Hypoplasia of the sacrum (HP:0008517)3.20006124
21Hepatic necrosis (HP:0002605)3.13683063
22Renal Fanconi syndrome (HP:0001994)3.12944960
23Pancreatic cysts (HP:0001737)2.98382482
24Nephronophthisis (HP:0000090)2.91610635
25True hermaphroditism (HP:0010459)2.79614453
26Medial flaring of the eyebrow (HP:0010747)2.77376850
27Absent thumb (HP:0009777)2.75269836
28Increased intramyocellular lipid droplets (HP:0012240)2.70943519
29Cerebral edema (HP:0002181)2.68140709
30Abnormality of renal resorption (HP:0011038)2.64734630
31Sclerocornea (HP:0000647)2.51121449
32Congenital stationary night blindness (HP:0007642)2.48313494
33Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.48125413
34Colon cancer (HP:0003003)2.43136270
35Exertional dyspnea (HP:0002875)2.40290340
36Gait imbalance (HP:0002141)2.39460730
37Type II lissencephaly (HP:0007260)2.38305370
38Myokymia (HP:0002411)2.33758413
39Abnormality of the renal medulla (HP:0100957)2.33707667
40Pendular nystagmus (HP:0012043)2.31520435
413-Methylglutaconic aciduria (HP:0003535)2.31115820
42Abnormal ciliary motility (HP:0012262)2.28956853
43Optic nerve hypoplasia (HP:0000609)2.28469996
44Stenosis of the external auditory canal (HP:0000402)2.27699942
45Increased serum lactate (HP:0002151)2.26810936
46Anophthalmia (HP:0000528)2.25921704
47Optic disc pallor (HP:0000543)2.25610718
48Absent rod-and cone-mediated responses on ERG (HP:0007688)2.25508367
49Anencephaly (HP:0002323)2.24969638
50Depressed nasal ridge (HP:0000457)2.24559871
51Aplasia/Hypoplasia of the spleen (HP:0010451)2.23633250
52Congenital primary aphakia (HP:0007707)2.22346467
53Abnormal biliary tract physiology (HP:0012439)2.21636681
54Bile duct proliferation (HP:0001408)2.21636681
55Hypoplasia of the pons (HP:0012110)2.21205147
56Type 2 muscle fiber atrophy (HP:0003554)2.20975028
57Dynein arm defect of respiratory motile cilia (HP:0012255)2.20108786
58Absent/shortened dynein arms (HP:0200106)2.20108786
59Increased muscle lipid content (HP:0009058)2.19826054
60Asplenia (HP:0001746)2.19823738
61Growth hormone deficiency (HP:0000824)2.18880795
62Abnormality of the labia minora (HP:0012880)2.13427847
63Maternal diabetes (HP:0009800)2.11762104
64Hyperglycinemia (HP:0002154)2.10675351
65Nephrogenic diabetes insipidus (HP:0009806)2.10498773
66Absent septum pellucidum (HP:0001331)2.08658635
67Lactic acidosis (HP:0003128)2.08119900
68Respiratory difficulties (HP:0002880)2.08031576
69Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.07297510
70Cystic liver disease (HP:0006706)2.07191191
71Supernumerary spleens (HP:0009799)2.06129724
72Abnormal respiratory epithelium morphology (HP:0012253)2.04949232
73Abnormal respiratory motile cilium morphology (HP:0005938)2.04949232
74Abnormal respiratory motile cilium physiology (HP:0012261)2.02328268
75Ectopic kidney (HP:0000086)1.97749879
76Hypoplasia of the radius (HP:0002984)1.96626549
77Glycosuria (HP:0003076)1.95521641
78Abnormality of urine glucose concentration (HP:0011016)1.95521641
79Hyperphosphaturia (HP:0003109)1.95092253
80Triphalangeal thumb (HP:0001199)1.94989466
81Abnormality of the renal cortex (HP:0011035)1.94682414
82Postaxial foot polydactyly (HP:0001830)1.94610963
83Abnormal rod and cone electroretinograms (HP:0008323)1.93829387
84Abnormality of the pons (HP:0007361)1.93285477
85Congenital, generalized hypertrichosis (HP:0004540)1.92735173
86Muscle fiber atrophy (HP:0100295)1.88888010
87Leukodystrophy (HP:0002415)1.88665268
88Abnormality of the phalanges of the 5th finger (HP:0004213)1.87330971
89Symphalangism affecting the phalanges of the hand (HP:0009773)1.87134519
90Adrenal hypoplasia (HP:0000835)1.86797291
91Exercise intolerance (HP:0003546)1.86776075
92Pachygyria (HP:0001302)1.86246024
93Respiratory failure (HP:0002878)1.85717504
94Abnormality of DNA repair (HP:0003254)1.84232590
95Esophageal atresia (HP:0002032)1.81882826
96Partial duplication of thumb phalanx (HP:0009944)1.79565739
97Poor suck (HP:0002033)1.79551228
98Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.77656299
99Vaginal atresia (HP:0000148)1.76701915
100Genital tract atresia (HP:0001827)1.74443853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE13.75881640
2VRK23.40741768
3STK163.36230582
4WNK42.98703602
5GRK12.91820777
6EPHB22.54214793
7DYRK22.50399278
8NUAK12.43432881
9BCKDK2.06056346
10CASK1.93129765
11TXK1.83407921
12NME11.82018426
13ZAK1.81923063
14ADRBK21.79310306
15PASK1.74114961
16VRK11.72685557
17CDK191.70095328
18TLK11.61121015
19WNK31.60033563
20BMPR1B1.57698695
21STK391.57007166
22LRRK21.54931073
23NTRK21.53329965
24CAMKK21.46181385
25MAP4K21.40153482
26FRK1.34281156
27PINK11.32467722
28TAOK31.27128928
29TAF11.26917028
30NME21.25494313
31PIK3CA1.24242796
32PDK21.19300564
33PAK31.16319484
34EPHA41.15345815
35MKNK21.13644779
36MARK11.07996119
37MAPK151.06812650
38CDK81.05993441
39CAMK11.03518746
40PRKCG1.01442204
41TNIK0.97844504
42MAP3K90.90402290
43PLK30.89942037
44PLK40.89133361
45TGFBR10.86952164
46TYRO30.85703359
47DAPK30.85362886
48TSSK60.84940034
49CAMKK10.83646273
50MAPK130.79730382
51CDC70.77398965
52CAMK1D0.77221988
53PHKG20.77104532
54PHKG10.77104532
55MAP3K40.75208866
56WNK10.74770725
57INSRR0.73387627
58CSNK2A20.71340709
59CHEK20.67410845
60TEC0.66507914
61NEK10.65880884
62AURKA0.64244512
63PRKACA0.64099482
64MAP3K120.64051898
65AURKB0.62363534
66MKNK10.61061855
67CSNK1E0.60748474
68MAP2K70.60742219
69KIT0.60136479
70STK110.59680934
71OXSR10.57895730
72ADRBK10.57698656
73MINK10.56943614
74PRKCQ0.55425572
75PLK20.52321947
76CSNK2A10.51458746
77CSNK1G20.44455716
78LIMK10.44380900
79FGFR20.44010166
80PIM20.43310676
81GRK50.43214724
82OBSCN0.42765124
83RPS6KA60.42753831
84CCNB10.42587318
85PLK10.41111675
86PRKCZ0.40382215
87CDK30.40061439
88CSNK1A10.39217013
89SRPK10.39076028
90BUB10.38882941
91CAMK2A0.36967699
92MAP3K110.36927549
93MST40.36039763
94RPS6KA50.35854891
95ILK0.35112549
96PRKCE0.33958135
97BRSK10.33380032
98PRKCA0.33125430
99PRKG10.32428817
100PNCK0.31152616

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.31618718
2Oxidative phosphorylation_Homo sapiens_hsa001904.82003527
3Parkinsons disease_Homo sapiens_hsa050124.09134135
4Huntingtons disease_Homo sapiens_hsa050163.00035528
5Alzheimers disease_Homo sapiens_hsa050102.80810700
6Cardiac muscle contraction_Homo sapiens_hsa042602.74374138
7RNA polymerase_Homo sapiens_hsa030202.72736104
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.53121221
9Protein export_Homo sapiens_hsa030602.38170825
10Proteasome_Homo sapiens_hsa030502.09060060
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.83579077
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68685980
13Homologous recombination_Homo sapiens_hsa034401.63097355
14RNA degradation_Homo sapiens_hsa030181.56887566
15Sulfur relay system_Homo sapiens_hsa041221.56491221
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.51135437
17Linoleic acid metabolism_Homo sapiens_hsa005911.48143935
18Nicotine addiction_Homo sapiens_hsa050331.30912715
19Basal transcription factors_Homo sapiens_hsa030221.30738540
20Pyrimidine metabolism_Homo sapiens_hsa002401.30221349
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21293051
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20517212
23Mismatch repair_Homo sapiens_hsa034301.20201596
24Phototransduction_Homo sapiens_hsa047441.18657383
25Fanconi anemia pathway_Homo sapiens_hsa034601.18516733
26Nucleotide excision repair_Homo sapiens_hsa034201.17123182
27Asthma_Homo sapiens_hsa053101.14475962
28One carbon pool by folate_Homo sapiens_hsa006701.14071368
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09658861
30Propanoate metabolism_Homo sapiens_hsa006401.07849071
31Butanoate metabolism_Homo sapiens_hsa006501.03066312
32Tryptophan metabolism_Homo sapiens_hsa003800.99054298
33Purine metabolism_Homo sapiens_hsa002300.95564693
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93911549
35Peroxisome_Homo sapiens_hsa041460.93233985
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93231121
37Spliceosome_Homo sapiens_hsa030400.93114772
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90037226
39Collecting duct acid secretion_Homo sapiens_hsa049660.89491876
40Basal cell carcinoma_Homo sapiens_hsa052170.86204777
41DNA replication_Homo sapiens_hsa030300.81359941
42Intestinal immune network for IgA production_Homo sapiens_hsa046720.80214175
43RNA transport_Homo sapiens_hsa030130.78291391
44Metabolic pathways_Homo sapiens_hsa011000.75428099
45Fat digestion and absorption_Homo sapiens_hsa049750.74708798
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74341820
47Arachidonic acid metabolism_Homo sapiens_hsa005900.73478934
48Ether lipid metabolism_Homo sapiens_hsa005650.73304813
49Hedgehog signaling pathway_Homo sapiens_hsa043400.73023495
50Chemical carcinogenesis_Homo sapiens_hsa052040.72021888
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68336311
52Steroid biosynthesis_Homo sapiens_hsa001000.66713608
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66365235
54Nitrogen metabolism_Homo sapiens_hsa009100.65803990
55beta-Alanine metabolism_Homo sapiens_hsa004100.63602748
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62749536
57Base excision repair_Homo sapiens_hsa034100.62416966
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.61479662
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58444253
60Caffeine metabolism_Homo sapiens_hsa002320.58049865
61Morphine addiction_Homo sapiens_hsa050320.57793132
62Folate biosynthesis_Homo sapiens_hsa007900.57615866
63Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57169741
64Olfactory transduction_Homo sapiens_hsa047400.56713754
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56544558
66Arginine and proline metabolism_Homo sapiens_hsa003300.52060572
67Allograft rejection_Homo sapiens_hsa053300.51146526
68Retinol metabolism_Homo sapiens_hsa008300.50990928
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50143199
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.48502333
71Insulin secretion_Homo sapiens_hsa049110.48160631
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47023980
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46716016
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.46284688
75Selenocompound metabolism_Homo sapiens_hsa004500.45606075
76Fatty acid degradation_Homo sapiens_hsa000710.43816095
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43563735
78Pyruvate metabolism_Homo sapiens_hsa006200.42819683
79Autoimmune thyroid disease_Homo sapiens_hsa053200.42174012
80Glycerolipid metabolism_Homo sapiens_hsa005610.41436809
81GABAergic synapse_Homo sapiens_hsa047270.38327191
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36167021
83Glutamatergic synapse_Homo sapiens_hsa047240.36000703
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.31773423
85Vitamin digestion and absorption_Homo sapiens_hsa049770.31246501
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29793722
87Rheumatoid arthritis_Homo sapiens_hsa053230.29561729
88Serotonergic synapse_Homo sapiens_hsa047260.29560012
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28860102
90Axon guidance_Homo sapiens_hsa043600.28167127
91Cocaine addiction_Homo sapiens_hsa050300.27523600
92Glutathione metabolism_Homo sapiens_hsa004800.27230076
93Ovarian steroidogenesis_Homo sapiens_hsa049130.26505238
94Regulation of autophagy_Homo sapiens_hsa041400.26443638
95Starch and sucrose metabolism_Homo sapiens_hsa005000.26276843
96Taste transduction_Homo sapiens_hsa047420.25633125
97Sulfur metabolism_Homo sapiens_hsa009200.25250382
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.24617859
99Systemic lupus erythematosus_Homo sapiens_hsa053220.24547976
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22769673

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