RPL6P8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)7.67875350
2purinergic nucleotide receptor signaling pathway (GO:0035590)6.28773416
3intermediate filament organization (GO:0045109)5.94029440
4maturation of SSU-rRNA (GO:0030490)5.24585694
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.87893407
6negative regulation of mast cell activation (GO:0033004)4.63418900
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.56625533
8ATP synthesis coupled proton transport (GO:0015986)4.56625533
9adaptation of signaling pathway (GO:0023058)4.52430738
10establishment of protein localization to mitochondrial membrane (GO:0090151)4.37703644
11purinergic receptor signaling pathway (GO:0035587)4.16354513
12positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)4.05500648
13dopamine transport (GO:0015872)4.05107298
14G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.97083770
15positive regulation of T cell differentiation in thymus (GO:0033089)3.92564785
16mast cell activation involved in immune response (GO:0002279)3.92161991
17mast cell degranulation (GO:0043303)3.92161991
18endothelial cell chemotaxis (GO:0035767)3.86530349
19nonmotile primary cilium assembly (GO:0035058)3.60648796
20maternal behavior (GO:0042711)3.59785410
21fucose catabolic process (GO:0019317)3.59604598
22L-fucose metabolic process (GO:0042354)3.59604598
23L-fucose catabolic process (GO:0042355)3.59604598
24positive regulation of icosanoid secretion (GO:0032305)3.51186474
25regulation of female gonad development (GO:2000194)3.48291409
26negative regulation of glial cell differentiation (GO:0045686)3.47461683
27behavioral response to nicotine (GO:0035095)3.44260740
28mast cell activation (GO:0045576)3.41318865
29left/right axis specification (GO:0070986)3.40636586
30positive regulation of fatty acid transport (GO:2000193)3.37096022
31interferon-gamma production (GO:0032609)3.30802237
32piRNA metabolic process (GO:0034587)3.27362171
33seminiferous tubule development (GO:0072520)3.27178284
34negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.25981172
35epithelial cell maturation (GO:0002070)3.24212312
36viral transcription (GO:0019083)3.20657375
37centriole replication (GO:0007099)3.20570648
38translesion synthesis (GO:0019985)3.20020646
39synapsis (GO:0007129)3.17212659
40chaperone-mediated protein transport (GO:0072321)3.14685061
41cardiovascular system development (GO:0072358)3.12208002
42regulation of gamma-delta T cell differentiation (GO:0045586)3.11730945
43postreplication repair (GO:0006301)3.11040689
44protein neddylation (GO:0045116)3.09936364
45parental behavior (GO:0060746)3.08719669
46translational termination (GO:0006415)3.07675595
47protein prenylation (GO:0018342)3.05274078
48prenylation (GO:0097354)3.05274078
49cell wall macromolecule catabolic process (GO:0016998)3.02739525
50positive regulation of signal transduction by p53 class mediator (GO:1901798)2.99354852
51ribosomal small subunit biogenesis (GO:0042274)2.97880167
52NADH dehydrogenase complex assembly (GO:0010257)2.93869450
53mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.93869450
54mitochondrial respiratory chain complex I assembly (GO:0032981)2.93869450
55G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.92087378
56replicative senescence (GO:0090399)2.89818593
57regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.86958166
58regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.86958166
59chaperone mediated protein folding requiring cofactor (GO:0051085)2.84655557
60preassembly of GPI anchor in ER membrane (GO:0016254)2.84607432
61regulation of gamma-delta T cell activation (GO:0046643)2.83877622
62startle response (GO:0001964)2.82672179
63regulation of meiosis I (GO:0060631)2.82187350
64translational elongation (GO:0006414)2.81016076
65negative regulation of multicellular organism growth (GO:0040015)2.80714343
66behavioral response to cocaine (GO:0048148)2.80370319
67protein localization to cilium (GO:0061512)2.77969273
68intermediate filament cytoskeleton organization (GO:0045104)2.76156766
69epithelial cell differentiation involved in kidney development (GO:0035850)2.75498478
70rRNA catabolic process (GO:0016075)2.74301244
71intermediate filament-based process (GO:0045103)2.70848491
72nephron tubule morphogenesis (GO:0072078)2.70819312
73nephron epithelium morphogenesis (GO:0072088)2.70819312
74SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.70226832
75positive regulation of prostaglandin secretion (GO:0032308)2.68920780
76cotranslational protein targeting to membrane (GO:0006613)2.68450270
77tRNA methylation (GO:0030488)2.67989283
78regulation of icosanoid secretion (GO:0032303)2.66214779
79protein complex biogenesis (GO:0070271)2.65987984
80protein targeting to ER (GO:0045047)2.63072477
81intracellular protein transmembrane import (GO:0044743)2.62960347
82negative regulation of oligodendrocyte differentiation (GO:0048715)2.61857604
83synaptic transmission, dopaminergic (GO:0001963)2.60502414
84negative regulation of meiotic cell cycle (GO:0051447)2.60192648
85phosphatidylcholine acyl-chain remodeling (GO:0036151)2.60162415
86response to histamine (GO:0034776)2.58705193
87cell wall macromolecule metabolic process (GO:0044036)2.57530194
88endoderm formation (GO:0001706)2.57419333
89regulation of memory T cell differentiation (GO:0043380)2.56871628
90negative regulation of gliogenesis (GO:0014014)2.56860323
91oxidative phosphorylation (GO:0006119)2.56380825
92neuromuscular synaptic transmission (GO:0007274)2.53793421
93mitotic cell cycle arrest (GO:0071850)2.53059797
94RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.51998194
95tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.51998194
96GPI anchor metabolic process (GO:0006505)2.51415881
97establishment of protein localization to endoplasmic reticulum (GO:0072599)2.50933432
98protein-cofactor linkage (GO:0018065)2.49852596
99histone H3-K9 methylation (GO:0051567)2.48996172
100protein localization to endoplasmic reticulum (GO:0070972)2.46868846

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.74967115
2EZH2_22144423_ChIP-Seq_EOC_Human3.87227274
3ZNF274_21170338_ChIP-Seq_K562_Hela3.71961579
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.66688997
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.60030350
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.45668198
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.38251151
8TAF15_26573619_Chip-Seq_HEK293_Human2.83349784
9GBX2_23144817_ChIP-Seq_PC3_Human2.57702765
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.38133296
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.26757404
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21002844
13VDR_22108803_ChIP-Seq_LS180_Human2.17288787
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.12755348
15FUS_26573619_Chip-Seq_HEK293_Human2.12472927
16CBX2_27304074_Chip-Seq_ESCs_Mouse1.88827441
17AR_21572438_ChIP-Seq_LNCaP_Human1.80493467
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76359332
19EZH2_27304074_Chip-Seq_ESCs_Mouse1.67326080
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62784272
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.61924735
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.59950667
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.57911742
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56390322
25CBP_20019798_ChIP-Seq_JUKART_Human1.55619337
26IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55619337
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52804501
28NANOG_19829295_ChIP-Seq_ESCs_Human1.51638588
29SOX2_19829295_ChIP-Seq_ESCs_Human1.51638588
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50774574
31POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.50168479
32TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50168479
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47986418
34P300_19829295_ChIP-Seq_ESCs_Human1.46045996
35RNF2_27304074_Chip-Seq_NSC_Mouse1.45778564
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45241121
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.44491848
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42813368
39MYC_18940864_ChIP-ChIP_HL60_Human1.41972352
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.41103515
41EGR1_23403033_ChIP-Seq_LIVER_Mouse1.38789101
42WDR5_24793694_ChIP-Seq_LNCAP_Human1.37705252
43TP53_22573176_ChIP-Seq_HFKS_Human1.34148103
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34010163
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.34010163
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29695801
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28858279
48IRF8_21731497_ChIP-ChIP_J774_Mouse1.28309756
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28041590
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27458967
51SMAD4_21741376_ChIP-Seq_EPCs_Human1.27057417
52TDRD3_21172665_ChIP-Seq_MCF-7_Human1.22847833
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22404462
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.22082976
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21525989
56EWS_26573619_Chip-Seq_HEK293_Human1.20404569
57PRDM14_20953172_ChIP-Seq_ESCs_Human1.19274812
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19240938
59NCOR_22424771_ChIP-Seq_293T_Human1.19148510
60MYC_19829295_ChIP-Seq_ESCs_Human1.18979105
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18762718
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18521816
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.17997291
64ETV2_25802403_ChIP-Seq_MESCs_Mouse1.15791194
65JARID2_20064375_ChIP-Seq_MESCs_Mouse1.14649732
66IRF1_19129219_ChIP-ChIP_H3396_Human1.14152136
67IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.10828416
68REST_21632747_ChIP-Seq_MESCs_Mouse1.10765366
69CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.10058181
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10001085
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09357430
72AR_25329375_ChIP-Seq_VCAP_Human1.09269310
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08329976
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.07379254
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.07335116
76FOXH1_21741376_ChIP-Seq_EPCs_Human1.06598278
77ETV1_20927104_ChIP-Seq_GIST48_Human1.06558104
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06046247
79PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05346721
80GATA3_26560356_Chip-Seq_TH2_Human1.04774118
81AR_20517297_ChIP-Seq_VCAP_Human1.03547128
82ELK1_19687146_ChIP-ChIP_HELA_Human1.03484796
83TCF4_23295773_ChIP-Seq_U87_Human1.02630223
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.01103632
85EED_16625203_ChIP-ChIP_MESCs_Mouse1.00397669
86EZH2_27294783_Chip-Seq_NPCs_Mouse0.99900594
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99129561
88TAL1_26923725_Chip-Seq_HPCs_Mouse0.99113828
89SMAD4_21799915_ChIP-Seq_A2780_Human0.98755817
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98092298
91FLI1_21867929_ChIP-Seq_TH2_Mouse0.97894323
92FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97792825
93RUNX_20019798_ChIP-Seq_JUKART_Human0.97542913
94STAT3_23295773_ChIP-Seq_U87_Human0.96379635
95GATA3_21878914_ChIP-Seq_MCF-7_Human0.95986952
96VDR_23849224_ChIP-Seq_CD4+_Human0.95872484
97P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93912690
98P53_22387025_ChIP-Seq_ESCs_Mouse0.93862124
99KDM2B_26808549_Chip-Seq_REH_Human0.93203466
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92426106

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005423_abnormal_somatic_nervous5.50084531
2MP0008875_abnormal_xenobiotic_pharmacok4.07013044
3MP0005671_abnormal_response_to3.39401080
4MP0002876_abnormal_thyroid_physiology3.21635930
5MP0003724_increased_susceptibility_to2.95066134
6MP0009379_abnormal_foot_pigmentation2.85552098
7MP0008877_abnormal_DNA_methylation2.50553919
8MP0003787_abnormal_imprinting2.29631363
9MP0002735_abnormal_chemical_nociception2.24792759
10MP0003950_abnormal_plasma_membrane2.24469538
11MP0002653_abnormal_ependyma_morphology2.24292597
12MP0006276_abnormal_autonomic_nervous2.22610112
13MP0004885_abnormal_endolymph2.20518148
14MP0001905_abnormal_dopamine_level2.14449956
15MP0003283_abnormal_digestive_organ2.11099787
16MP0005451_abnormal_body_composition2.09949574
17MP0003806_abnormal_nucleotide_metabolis2.07549288
18MP0008872_abnormal_physiological_respon2.05277157
19MP0006072_abnormal_retinal_apoptosis1.95313770
20MP0009278_abnormal_bone_marrow1.94928676
21MP0005646_abnormal_pituitary_gland1.76786504
22MP0009745_abnormal_behavioral_response1.72635369
23MP0002272_abnormal_nervous_system1.68878988
24MP0000537_abnormal_urethra_morphology1.58567371
25MP0005171_absent_coat_pigmentation1.56188767
26MP0002148_abnormal_hypersensitivity_rea1.54782103
27MP0004742_abnormal_vestibular_system1.50370079
28MP0009785_altered_susceptibility_to1.43948292
29MP0005075_abnormal_melanosome_morpholog1.40401514
30MP0010386_abnormal_urinary_bladder1.40361714
31MP0009046_muscle_twitch1.39265037
32MP0005397_hematopoietic_system_phenotyp1.38512352
33MP0001545_abnormal_hematopoietic_system1.38512352
34MP0001486_abnormal_startle_reflex1.36660883
35MP0006292_abnormal_olfactory_placode1.33976342
36MP0002751_abnormal_autonomic_nervous1.26159681
37MP0009697_abnormal_copulation1.24976645
38MP0001970_abnormal_pain_threshold1.24004853
39MP0001968_abnormal_touch/_nociception1.23429610
40MP0004133_heterotaxia1.21968442
41MP0001800_abnormal_humoral_immune1.20904001
42MP0003880_abnormal_central_pattern1.20742157
43MP0002572_abnormal_emotion/affect_behav1.19784427
44MP0000372_irregular_coat_pigmentation1.19639217
45MP0003937_abnormal_limbs/digits/tail_de1.18954710
46MP0003011_delayed_dark_adaptation1.17908554
47MP0009764_decreased_sensitivity_to1.16369602
48MP0000631_abnormal_neuroendocrine_gland1.15995157
49MP0003136_yellow_coat_color1.12827701
50MP0003121_genomic_imprinting1.12408589
51MP0004142_abnormal_muscle_tone1.12042608
52MP0005000_abnormal_immune_tolerance1.09740626
53MP0001501_abnormal_sleep_pattern1.08161679
54MP0002063_abnormal_learning/memory/cond1.04474161
55MP0005253_abnormal_eye_physiology1.02168115
56MP0005551_abnormal_eye_electrophysiolog1.01837870
57MP0004145_abnormal_muscle_electrophysio1.00970988
58MP0002723_abnormal_immune_serum1.00227989
59MP0002102_abnormal_ear_morphology0.99727966
60MP0003638_abnormal_response/metabolism_0.99418883
61MP0001879_abnormal_lymphatic_vessel0.96421951
62MP0005084_abnormal_gallbladder_morpholo0.95954426
63MP0002557_abnormal_social/conspecific_i0.95541823
64MP0002452_abnormal_antigen_presenting0.93736135
65MP0001919_abnormal_reproductive_system0.90812864
66MP0001764_abnormal_homeostasis0.88798047
67MP0001819_abnormal_immune_cell0.87338131
68MP0000955_abnormal_spinal_cord0.87239845
69MP0002277_abnormal_respiratory_mucosa0.86817725
70MP0005389_reproductive_system_phenotype0.86680694
71MP0002420_abnormal_adaptive_immunity0.86353103
72MP0001727_abnormal_embryo_implantation0.85395963
73MP0002733_abnormal_thermal_nociception0.85171923
74MP0000026_abnormal_inner_ear0.84880710
75MP0003635_abnormal_synaptic_transmissio0.84701657
76MP0001440_abnormal_grooming_behavior0.84494437
77MP0002638_abnormal_pupillary_reflex0.82846567
78MP0002736_abnormal_nociception_after0.82329319
79MP0003122_maternal_imprinting0.80624872
80MP0001835_abnormal_antigen_presentation0.80411606
81MP0003631_nervous_system_phenotype0.80163114
82MP0002006_tumorigenesis0.79897188
83MP0001984_abnormal_olfaction0.77885560
84MP0008058_abnormal_DNA_repair0.77860008
85MP0003646_muscle_fatigue0.76901045
86MP0000230_abnormal_systemic_arterial0.76684663
87MP0002734_abnormal_mechanical_nocicepti0.75973005
88MP0005387_immune_system_phenotype0.75481039
89MP0001790_abnormal_immune_system0.75481039
90MP0001958_emphysema0.75294780
91MP0003633_abnormal_nervous_system0.74751280
92MP0000639_abnormal_adrenal_gland0.74579607
93MP0002067_abnormal_sensory_capabilities0.74406512
94MP0001765_abnormal_ion_homeostasis0.74058084
95MP0002938_white_spotting0.72999358
96MP0001986_abnormal_taste_sensitivity0.69474307
97MP0005410_abnormal_fertilization0.68014596
98MP0000685_abnormal_immune_system0.67352552
99MP0003632_abnormal_nervous_system0.65657516
100MP0004147_increased_porphyrin_level0.65637605

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)8.57344901
2B lymphocytopenia (HP:0010976)4.37128359
3Medial flaring of the eyebrow (HP:0010747)4.12500845
4Colon cancer (HP:0003003)4.00709923
5Panhypogammaglobulinemia (HP:0003139)3.92661735
6Abnormality of B cell number (HP:0010975)3.71329986
7Abnormality of the prostate (HP:0008775)3.67002761
8Prostate neoplasm (HP:0100787)3.49169489
9Congenital stationary night blindness (HP:0007642)3.45016143
10Ulnar claw (HP:0001178)3.28278266
11Pancreatic fibrosis (HP:0100732)3.20375538
12Metaphyseal dysplasia (HP:0100255)3.20330199
13True hermaphroditism (HP:0010459)3.18171923
14Stomach cancer (HP:0012126)3.14912091
15Abnormality of lateral ventricle (HP:0030047)3.11161020
16Congenital primary aphakia (HP:0007707)2.94543819
17Gait imbalance (HP:0002141)2.90098284
18Hypoplasia of the thymus (HP:0000778)2.86397710
19Abnormality of midbrain morphology (HP:0002418)2.85198378
20Molar tooth sign on MRI (HP:0002419)2.85198378
21Sclerocornea (HP:0000647)2.79866216
22Reticulocytopenia (HP:0001896)2.79398013
23Severe combined immunodeficiency (HP:0004430)2.74389476
24Palmoplantar hyperkeratosis (HP:0000972)2.73125685
25Abnormality of the renal cortex (HP:0011035)2.72336310
26Renal cortical cysts (HP:0000803)2.71533638
27Pancreatic cysts (HP:0001737)2.70976428
28Nephrogenic diabetes insipidus (HP:0009806)2.69079047
29Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.67574611
30Global brain atrophy (HP:0002283)2.67148511
31Birth length less than 3rd percentile (HP:0003561)2.62700514
32Adrenal hypoplasia (HP:0000835)2.59965043
33Papilloma (HP:0012740)2.57758430
34Verrucae (HP:0200043)2.57758430
35Abnormality of the frontal sinuses (HP:0002687)2.57384698
36Hypoproteinemia (HP:0003075)2.50765084
37Thyroiditis (HP:0100646)2.49458666
38Chronic otitis media (HP:0000389)2.45674523
39Nephronophthisis (HP:0000090)2.45533159
40Genital tract atresia (HP:0001827)2.42337961
41Medulloblastoma (HP:0002885)2.41646118
42Palmar hyperkeratosis (HP:0010765)2.40736353
43Hypergammaglobulinemia (HP:0010702)2.40322995
44Abnormality of cells of the erythroid lineage (HP:0012130)2.38053402
45Anencephaly (HP:0002323)2.33036113
46Alveolar cell carcinoma (HP:0006519)2.25099737
47Dynein arm defect of respiratory motile cilia (HP:0012255)2.25015175
48Absent/shortened dynein arms (HP:0200106)2.25015175
49Depressed nasal tip (HP:0000437)2.19476285
50Decreased central vision (HP:0007663)2.18536479
51Abnormality of male internal genitalia (HP:0000022)2.18053111
52Neoplasm of the tracheobronchial system (HP:0100552)2.17978373
53Focal motor seizures (HP:0011153)2.17296627
54Absent rod-and cone-mediated responses on ERG (HP:0007688)2.17098577
55Stenosis of the external auditory canal (HP:0000402)2.16462156
56Retinal atrophy (HP:0001105)2.15022175
57Abnormal hemoglobin (HP:0011902)2.14381740
58Septo-optic dysplasia (HP:0100842)2.12615969
59Long nose (HP:0003189)2.12585717
60Vaginal atresia (HP:0000148)2.09536982
61Male pseudohermaphroditism (HP:0000037)2.04685068
62Focal seizures (HP:0007359)2.02770544
63Plantar hyperkeratosis (HP:0007556)2.02310303
64Abnormality of the renal medulla (HP:0100957)2.01258963
65Median cleft lip (HP:0000161)2.00002285
66Abnormality of the phalanges of the 2nd finger (HP:0009541)1.97890861
67T lymphocytopenia (HP:0005403)1.97096386
68Hyperalaninemia (HP:0003348)1.95975441
69Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.95975441
70Abnormality of alanine metabolism (HP:0010916)1.95975441
71Febrile seizures (HP:0002373)1.95284495
72Abnormal rod and cone electroretinograms (HP:0008323)1.94923118
73Congenital, generalized hypertrichosis (HP:0004540)1.92869507
74Optic disc pallor (HP:0000543)1.91911090
75Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.90453364
76Combined immunodeficiency (HP:0005387)1.89124687
77Brushfield spots (HP:0001088)1.88476273
78Abnormality of the diencephalon (HP:0010662)1.88039070
79Poor coordination (HP:0002370)1.86198116
80Vacuolated lymphocytes (HP:0001922)1.85899969
81Abolished electroretinogram (ERG) (HP:0000550)1.84480804
82Distal arthrogryposis (HP:0005684)1.83696601
83Acute necrotizing encephalopathy (HP:0006965)1.83614621
84Glioma (HP:0009733)1.79369074
85Overriding aorta (HP:0002623)1.79107068
86Encephalitis (HP:0002383)1.77963658
87Cystic liver disease (HP:0006706)1.77853239
88Hemiparesis (HP:0001269)1.76892273
89Abnormality of the carotid arteries (HP:0005344)1.76630152
90Concave nail (HP:0001598)1.76329353
91Absent frontal sinuses (HP:0002688)1.76138021
92IgG deficiency (HP:0004315)1.75435049
93Pendular nystagmus (HP:0012043)1.75125584
94Abnormality of the labia minora (HP:0012880)1.74129671
95Pachygyria (HP:0001302)1.73634367
96Progressive macrocephaly (HP:0004481)1.72774979
97Nephrotic syndrome (HP:0000100)1.71403760
98Chronic sinusitis (HP:0011109)1.71300865
99Patellar aplasia (HP:0006443)1.67635816
100Abnormal number of erythroid precursors (HP:0012131)1.67181993

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK37.00761542
2NME13.45387541
3PNCK3.39490896
4ZAK2.95989896
5NUAK12.83028334
6PINK12.68802396
7KIT2.28110132
8TAOK12.25986543
9DYRK32.23476535
10MAPKAPK52.07769374
11ADRBK22.06238148
12TLK12.03011427
13FLT31.98907372
14CDK191.97169671
15MAPK151.89973883
16MAP2K21.86900109
17WEE11.82761974
18MAP4K21.54247886
19MAPKAPK31.51443953
20PLK41.42893665
21FRK1.40001230
22GRK11.22432709
23PIK3CA1.20526006
24WNK31.17910438
25CSNK1G31.17625091
26STK111.15795751
27EIF2AK31.11753511
28MAP3K121.10862230
29CSNK1G21.04485706
30SYK1.02093990
31BMPR21.00377803
32ICK0.98925191
33BRSK20.97812673
34TRPM70.97621526
35MARK30.95995729
36PTK2B0.91896341
37VRK10.90906596
38SCYL20.89622738
39PIM10.88620582
40PHKG10.86439440
41PHKG20.86439440
42CDK30.86093343
43TSSK60.84695384
44CSNK1G10.83337654
45TEC0.79403443
46MAPK130.79008499
47MAP3K40.78540408
48IRAK40.78239556
49CSNK1A1L0.77365956
50MKNK10.76537469
51PRKCG0.76485644
52VRK20.76098989
53PIK3CG0.73409946
54WNK40.72929837
55NTRK30.67439264
56GRK60.66829782
57ITK0.65884000
58PRKCQ0.64932542
59INSRR0.64848433
60TESK20.62213545
61BCKDK0.59167250
62DYRK20.58104275
63TIE10.56143323
64ACVR1B0.55551182
65MYLK0.54778059
66LATS10.53725235
67RPS6KA60.53155814
68TNK20.52734669
69BRSK10.52605427
70MELK0.52291273
71MAP3K110.51921495
72JAK30.50197232
73PLK30.50106308
74CSF1R0.48720188
75WNK10.45440588
76LYN0.44972416
77PLK20.44345022
78LCK0.43325624
79RPS6KL10.42980817
80RPS6KC10.42980817
81GRK50.42085859
82DYRK1A0.41869907
83SRPK10.41809197
84OBSCN0.40842961
85ADRBK10.38414891
86NEK20.36667945
87FES0.35994452
88CHUK0.35229738
89DAPK10.34482336
90MKNK20.34088684
91MAP3K140.33072513
92PKN10.32856782
93IGF1R0.32773018
94PRKG10.32437153
95IKBKE0.32300053
96BMPR1B0.31387106
97MAPK120.31204312
98CAMK2A0.30976968
99HIPK20.29918652
100TAF10.29417280

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.82503021
2Ribosome_Homo sapiens_hsa030103.28009595
3Caffeine metabolism_Homo sapiens_hsa002323.26212289
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.17002314
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.74450193
6Allograft rejection_Homo sapiens_hsa053302.45461114
7Graft-versus-host disease_Homo sapiens_hsa053322.42290434
8Oxidative phosphorylation_Homo sapiens_hsa001902.40868648
9Autoimmune thyroid disease_Homo sapiens_hsa053202.40525883
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.27074760
11Protein export_Homo sapiens_hsa030602.10730469
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09825298
13Parkinsons disease_Homo sapiens_hsa050122.08346549
14Linoleic acid metabolism_Homo sapiens_hsa005911.86261532
15Type I diabetes mellitus_Homo sapiens_hsa049401.85853659
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.80980958
17Nitrogen metabolism_Homo sapiens_hsa009101.80186212
18Primary immunodeficiency_Homo sapiens_hsa053401.78185892
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.75646578
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.70623304
21Mismatch repair_Homo sapiens_hsa034301.70038950
22Antigen processing and presentation_Homo sapiens_hsa046121.55119756
23Nicotine addiction_Homo sapiens_hsa050331.46291324
24Staphylococcus aureus infection_Homo sapiens_hsa051501.44737698
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44631191
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.44158875
27Leishmaniasis_Homo sapiens_hsa051401.37976331
28Rheumatoid arthritis_Homo sapiens_hsa053231.32165065
29Alzheimers disease_Homo sapiens_hsa050101.23525880
30Fanconi anemia pathway_Homo sapiens_hsa034601.21707514
31Huntingtons disease_Homo sapiens_hsa050161.20663298
32Hematopoietic cell lineage_Homo sapiens_hsa046401.16895267
33Proteasome_Homo sapiens_hsa030501.16366456
34RNA polymerase_Homo sapiens_hsa030201.15545167
35Butanoate metabolism_Homo sapiens_hsa006501.15243658
36Cardiac muscle contraction_Homo sapiens_hsa042601.14790851
37Collecting duct acid secretion_Homo sapiens_hsa049661.13709917
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12905038
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12556844
40Phototransduction_Homo sapiens_hsa047441.11915570
41Chemical carcinogenesis_Homo sapiens_hsa052041.07747567
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05608776
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98166176
44Tryptophan metabolism_Homo sapiens_hsa003800.97053487
45Homologous recombination_Homo sapiens_hsa034400.93833099
46Viral myocarditis_Homo sapiens_hsa054160.89861970
47Taste transduction_Homo sapiens_hsa047420.89728201
48Salivary secretion_Homo sapiens_hsa049700.89181764
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88691472
50Ether lipid metabolism_Homo sapiens_hsa005650.88238753
51Arachidonic acid metabolism_Homo sapiens_hsa005900.87689658
52Propanoate metabolism_Homo sapiens_hsa006400.80030707
53Morphine addiction_Homo sapiens_hsa050320.76427109
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74314723
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74008186
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72514279
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72122463
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71153284
59GABAergic synapse_Homo sapiens_hsa047270.71046872
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.65649805
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65461711
62Fat digestion and absorption_Homo sapiens_hsa049750.63413478
63Systemic lupus erythematosus_Homo sapiens_hsa053220.62575331
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62323040
65DNA replication_Homo sapiens_hsa030300.60838912
66Ovarian steroidogenesis_Homo sapiens_hsa049130.59506309
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58560108
68Regulation of autophagy_Homo sapiens_hsa041400.57159942
69Glutamatergic synapse_Homo sapiens_hsa047240.56011664
70One carbon pool by folate_Homo sapiens_hsa006700.55645186
71Serotonergic synapse_Homo sapiens_hsa047260.55439019
72Folate biosynthesis_Homo sapiens_hsa007900.52155047
73Basal transcription factors_Homo sapiens_hsa030220.50825207
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49927580
75Toxoplasmosis_Homo sapiens_hsa051450.48963051
76Retinol metabolism_Homo sapiens_hsa008300.48264534
77Peroxisome_Homo sapiens_hsa041460.47718328
78Phagosome_Homo sapiens_hsa041450.47273972
79Circadian entrainment_Homo sapiens_hsa047130.46904621
80Olfactory transduction_Homo sapiens_hsa047400.45251324
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43484873
82Calcium signaling pathway_Homo sapiens_hsa040200.42900028
83Renin secretion_Homo sapiens_hsa049240.39980415
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39767533
85p53 signaling pathway_Homo sapiens_hsa041150.39126675
86Purine metabolism_Homo sapiens_hsa002300.39012049
87Spliceosome_Homo sapiens_hsa030400.38014996
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37817847
89Histidine metabolism_Homo sapiens_hsa003400.37702611
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.35993124
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35644597
92Herpes simplex infection_Homo sapiens_hsa051680.35376528
93African trypanosomiasis_Homo sapiens_hsa051430.35025745
94RNA degradation_Homo sapiens_hsa030180.32416018
95Cholinergic synapse_Homo sapiens_hsa047250.28690787
96Nucleotide excision repair_Homo sapiens_hsa034200.27283091
97Tuberculosis_Homo sapiens_hsa051520.27110697
98Oxytocin signaling pathway_Homo sapiens_hsa049210.26263959
99Long-term depression_Homo sapiens_hsa047300.25897688
100Base excision repair_Homo sapiens_hsa034100.25453216

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