RPL7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus submotif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.47281173
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.41403875
3* viral transcription (GO:0019083)6.94460024
4* translational termination (GO:0006415)6.74724610
5ATP synthesis coupled proton transport (GO:0015986)6.52000779
6energy coupled proton transport, down electrochemical gradient (GO:0015985)6.52000779
7ribosomal small subunit biogenesis (GO:0042274)6.20516663
8maturation of SSU-rRNA (GO:0030490)6.17208675
9* translational elongation (GO:0006414)5.92582301
10* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.68157073
11* cotranslational protein targeting to membrane (GO:0006613)5.55602926
12* protein targeting to ER (GO:0045047)5.55281977
13* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.50527458
14* translational initiation (GO:0006413)5.36516971
15* establishment of protein localization to endoplasmic reticulum (GO:0072599)5.30384396
16* viral life cycle (GO:0019058)5.24886117
17* cellular protein complex disassembly (GO:0043624)5.22638913
18* protein localization to endoplasmic reticulum (GO:0070972)5.17670090
19formation of translation preinitiation complex (GO:0001731)4.79401922
20* ribosomal large subunit biogenesis (GO:0042273)4.77504492
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.76872092
22respiratory electron transport chain (GO:0022904)4.70526893
23establishment of protein localization to mitochondrial membrane (GO:0090151)4.69615089
24* protein complex disassembly (GO:0043241)4.66159638
25electron transport chain (GO:0022900)4.61814308
26* macromolecular complex disassembly (GO:0032984)4.36566638
27DNA unwinding involved in DNA replication (GO:0006268)4.26068933
28* nuclear-transcribed mRNA catabolic process (GO:0000956)4.13359658
29* ribonucleoprotein complex biogenesis (GO:0022613)4.11675573
30DNA strand elongation involved in DNA replication (GO:0006271)4.11178202
31chaperone-mediated protein transport (GO:0072321)3.97738756
32* mRNA catabolic process (GO:0006402)3.92130215
33DNA strand elongation (GO:0022616)3.90453589
34oxidative phosphorylation (GO:0006119)3.85246194
35telomere maintenance via semi-conservative replication (GO:0032201)3.81091091
36* translation (GO:0006412)3.78898405
37protein complex biogenesis (GO:0070271)3.77836915
38* RNA catabolic process (GO:0006401)3.75275809
39DNA replication initiation (GO:0006270)3.74850635
40proteasome assembly (GO:0043248)3.71902291
41inner mitochondrial membrane organization (GO:0007007)3.70634942
42mitochondrial respiratory chain complex I assembly (GO:0032981)3.66342876
43NADH dehydrogenase complex assembly (GO:0010257)3.66342876
44mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.66342876
45mitochondrial respiratory chain complex assembly (GO:0033108)3.65775922
46* protein targeting to membrane (GO:0006612)3.63462192
47nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.62168077
48exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.51028182
49nucleobase biosynthetic process (GO:0046112)3.50416023
50protein neddylation (GO:0045116)3.49540027
51ATP biosynthetic process (GO:0006754)3.46164121
52* rRNA processing (GO:0006364)3.44799549
53telomere maintenance via recombination (GO:0000722)3.44148163
54* establishment of protein localization to membrane (GO:0090150)3.44044198
55protein localization to kinetochore (GO:0034501)3.41763024
56IMP biosynthetic process (GO:0006188)3.40590078
57mitotic recombination (GO:0006312)3.37672065
58ribosome assembly (GO:0042255)3.36338079
59* rRNA metabolic process (GO:0016072)3.33256406
60termination of RNA polymerase III transcription (GO:0006386)3.32499478
61transcription elongation from RNA polymerase III promoter (GO:0006385)3.32499478
62* protein targeting (GO:0006605)3.31028928
63purine nucleobase biosynthetic process (GO:0009113)3.28184005
64rRNA modification (GO:0000154)3.27496362
65nuclear pore organization (GO:0006999)3.21674509
66CENP-A containing nucleosome assembly (GO:0034080)3.21015589
67* establishment of protein localization to organelle (GO:0072594)3.20639420
68DNA replication-dependent nucleosome assembly (GO:0006335)3.20245532
69DNA replication-dependent nucleosome organization (GO:0034723)3.20245532
70purine nucleoside triphosphate biosynthetic process (GO:0009145)3.19667042
71chromatin remodeling at centromere (GO:0031055)3.19032832
72folic acid-containing compound biosynthetic process (GO:0009396)3.15114645
73mitotic nuclear envelope disassembly (GO:0007077)3.14702895
74ribosome biogenesis (GO:0042254)3.14302784
75purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.14083913
76DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.11929396
77telomere maintenance via telomere lengthening (GO:0010833)3.11755426
78signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.11536743
79signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.11536743
80signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.11536743
81DNA damage response, detection of DNA damage (GO:0042769)3.11011300
82IMP metabolic process (GO:0046040)3.10167057
83nucleotide-excision repair, DNA gap filling (GO:0006297)3.08950430
84mitotic metaphase plate congression (GO:0007080)3.08829479
85intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.07339971
86signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.07339971
87DNA replication checkpoint (GO:0000076)3.06485349
88hydrogen ion transmembrane transport (GO:1902600)3.03971150
89DNA replication-independent nucleosome organization (GO:0034724)3.02677896
90DNA replication-independent nucleosome assembly (GO:0006336)3.02677896
91signal transduction involved in DNA damage checkpoint (GO:0072422)2.98750612
92signal transduction involved in DNA integrity checkpoint (GO:0072401)2.98750612
93nuclear pore complex assembly (GO:0051292)2.98435611
94RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.98005087
95tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.98005087
96signal transduction involved in cell cycle checkpoint (GO:0072395)2.94916890
97DNA ligation (GO:0006266)2.92276545
98protein localization to chromosome, centromeric region (GO:0071459)2.90373920
99nuclear envelope disassembly (GO:0051081)2.89802549
100membrane disassembly (GO:0030397)2.89802549
101regulation of cellular amino acid metabolic process (GO:0006521)2.89345025
102purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.89321254
103purine nucleoside monophosphate biosynthetic process (GO:0009127)2.89321254
104* cellular component biogenesis (GO:0044085)2.88824020
105negative regulation of RNA splicing (GO:0033119)2.88763552
106establishment of integrated proviral latency (GO:0075713)2.88258550
107spliceosomal snRNP assembly (GO:0000387)2.87392397
108regulation of mitochondrial translation (GO:0070129)2.85917859
109positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.85732000
110regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.85372310
111regulation of mitotic spindle checkpoint (GO:1903504)2.84488513
112regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.84488513
113metaphase plate congression (GO:0051310)2.81184557
114ribonucleoside triphosphate biosynthetic process (GO:0009201)2.80819534
115kinetochore organization (GO:0051383)2.78935023
116aldehyde catabolic process (GO:0046185)2.78377685
117DNA duplex unwinding (GO:0032508)2.77271679
118sequestering of actin monomers (GO:0042989)2.76355254
119DNA geometric change (GO:0032392)2.75448167
120* protein localization to membrane (GO:0072657)2.73275318
121positive regulation of ligase activity (GO:0051351)2.73093716
122mismatch repair (GO:0006298)2.72986856
123proton transport (GO:0015992)2.72287239
124RNA splicing, via transesterification reactions (GO:0000375)2.72265880
125RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.72114255
126mRNA splicing, via spliceosome (GO:0000398)2.72114255
127negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.71910969
128mitotic chromosome condensation (GO:0007076)2.71161719
129DNA deamination (GO:0045006)2.70362445
130organelle disassembly (GO:1903008)2.68990969
131hydrogen transport (GO:0006818)2.67519541
132transcription-coupled nucleotide-excision repair (GO:0006283)2.67224986
133spliceosomal complex assembly (GO:0000245)2.65470944
134somatic hypermutation of immunoglobulin genes (GO:0016446)2.64221259
135somatic diversification of immune receptors via somatic mutation (GO:0002566)2.64221259
136regulation of histone H3-K9 methylation (GO:0051570)2.63669695
137pseudouridine synthesis (GO:0001522)2.63057565
138regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.62268481
139anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.60759965
140regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.60077718
141positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.59617319
142histone exchange (GO:0043486)2.59035750
143ncRNA 3-end processing (GO:0043628)2.58069395
144regulation of spindle organization (GO:0090224)2.57512158
145negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.56462398
146viral mRNA export from host cell nucleus (GO:0046784)2.55224183
147termination of RNA polymerase I transcription (GO:0006363)2.54056562
148ribonucleoprotein complex assembly (GO:0022618)2.53902486
149telomere maintenance (GO:0000723)2.53521565
150telomere organization (GO:0032200)2.53418809
151termination of RNA polymerase II transcription (GO:0006369)2.52148014
152attachment of spindle microtubules to kinetochore (GO:0008608)2.52054399
153* ncRNA processing (GO:0034470)2.51450680
154G1/S transition of mitotic cell cycle (GO:0000082)2.51309247
155cell cycle G1/S phase transition (GO:0044843)2.51309247
156regulation of helicase activity (GO:0051095)2.50811331
157negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.50583908
158negative regulation of ligase activity (GO:0051352)2.50583908

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.98007449
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.55429015
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.70192383
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.41923264
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.37152144
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.28872674
7* EST1_17652178_ChIP-ChIP_JURKAT_Human2.92300778
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.86478442
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.86368056
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80159562
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69053367
12* ETS1_20019798_ChIP-Seq_JURKAT_Human2.65478897
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.62495088
14XRN2_22483619_ChIP-Seq_HELA_Human2.50991073
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.48931657
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.37026942
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.35474231
18* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32472810
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.28152669
20VDR_23849224_ChIP-Seq_CD4+_Human2.22996826
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.15266985
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.14260727
23FUS_26573619_Chip-Seq_HEK293_Human2.09363192
24* SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.06331919
25* TTF2_22483619_ChIP-Seq_HELA_Human1.96440971
26FOXP3_21729870_ChIP-Seq_TREG_Human1.96004151
27EWS_26573619_Chip-Seq_HEK293_Human1.95214119
28DCP1A_22483619_ChIP-Seq_HELA_Human1.95165181
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.93673733
30ELK1_19687146_ChIP-ChIP_HELA_Human1.92589377
31AR_21909140_ChIP-Seq_LNCAP_Human1.91679305
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91546885
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89074923
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.83969497
35VDR_22108803_ChIP-Seq_LS180_Human1.83259965
36MYC_22102868_ChIP-Seq_BL_Human1.78989251
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.78047927
38ZNF274_21170338_ChIP-Seq_K562_Hela1.67967389
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65539461
40GABP_19822575_ChIP-Seq_HepG2_Human1.64529064
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62574235
42TP63_17297297_ChIP-ChIP_HaCaT_Human1.61643184
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.61071056
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60538359
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.58068713
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56868717
47CIITA_25753668_ChIP-Seq_RAJI_Human1.55231988
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.54331079
49* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53052238
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52237541
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50472838
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50239444
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49127218
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46092381
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45301440
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.44360297
57* FLI1_27457419_Chip-Seq_LIVER_Mouse1.42961832
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41503461
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39076565
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37218129
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.33778057
62FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32219645
63* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31886014
64* KDM5A_27292631_Chip-Seq_BREAST_Human1.31774118
65HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.31110602
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30536147
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29270562
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.28263295
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27961086
70* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.26963410
71IGF1R_20145208_ChIP-Seq_DFB_Human1.26732194
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24075551
73SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.24019755
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22569544
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21609979
76TAF15_26573619_Chip-Seq_HEK293_Human1.21572111
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21456769
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18826625
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18811391
80POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18792968
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.17455156
82YY1_21170310_ChIP-Seq_MESCs_Mouse1.16824532
83NANOG_16153702_ChIP-ChIP_HESCs_Human1.15821480
84IRF1_19129219_ChIP-ChIP_H3396_Human1.15394049
85* SOX2_16153702_ChIP-ChIP_HESCs_Human1.14355089
86TFEB_21752829_ChIP-Seq_HELA_Human1.14323236
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13105685
88VDR_21846776_ChIP-Seq_THP-1_Human1.11601081
89SRF_21415370_ChIP-Seq_HL-1_Mouse1.10775222
90ELK1_22589737_ChIP-Seq_MCF10A_Human1.09655243
91PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08089619
92NOTCH1_21737748_ChIP-Seq_TLL_Human1.07740471
93TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07290184
94* SPI1_23547873_ChIP-Seq_NB4_Human1.05363547
95CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04219572
96* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01343644
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00479766
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00266524
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99868894
100* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99247370
101TP53_22573176_ChIP-Seq_HFKS_Human0.98004179
102IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97764222
103TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97694105
104MYC_18940864_ChIP-ChIP_HL60_Human0.97343392
105* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97321920
106DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96156999
107P300_19829295_ChIP-Seq_ESCs_Human0.95096819
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94752749
109* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92464411
110RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92014758
111CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91442918
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90873493
113GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90777092
114BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90394952
115ERG_20517297_ChIP-Seq_VCAP_Human0.89264995
116CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.88437935
117FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87101252
118FOXA1_25329375_ChIP-Seq_VCAP_Human0.87101252
119MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.86022959
120NANOG_21062744_ChIP-ChIP_HESCs_Human0.84869446
121* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.84664535
122* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84200620
123* AR_20517297_ChIP-Seq_VCAP_Human0.84004666
124OCT4_18692474_ChIP-Seq_MEFs_Mouse0.83065300
125GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.82643686
126ELF5_23300383_ChIP-Seq_T47D_Human0.82267381
127KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.81900150
128KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.81900150
129KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.81900150
130PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.81435934
131RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.80657303
132NANOG_19829295_ChIP-Seq_ESCs_Human0.79494570
133SOX2_19829295_ChIP-Seq_ESCs_Human0.79494570
134CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.77880832
135SALL4_22934838_ChIP-ChIP_CD34+_Human0.77536492
136ER_23166858_ChIP-Seq_MCF-7_Human0.75845455

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.29429501
2MP0004957_abnormal_blastocyst_morpholog3.78769764
3MP0010094_abnormal_chromosome_stability3.60163386
4MP0006292_abnormal_olfactory_placode3.59640351
5MP0003077_abnormal_cell_cycle3.22628273
6MP0003111_abnormal_nucleus_morphology3.21097949
7MP0003136_yellow_coat_color3.00622089
8MP0008057_abnormal_DNA_replication2.75162939
9MP0008058_abnormal_DNA_repair2.53732003
10MP0008007_abnormal_cellular_replicative2.49300916
11MP0010352_gastrointestinal_tract_polyps2.44880646
12MP0006072_abnormal_retinal_apoptosis2.41892299
13MP0008995_early_reproductive_senescence2.41798713
14MP0002396_abnormal_hematopoietic_system2.37135643
15MP0009379_abnormal_foot_pigmentation2.34261278
16MP0000566_synostosis2.29874757
17MP0008932_abnormal_embryonic_tissue2.06158500
18MP0003123_paternal_imprinting2.05369864
19MP0009697_abnormal_copulation2.03221744
20MP0000372_irregular_coat_pigmentation2.02125414
21MP0001730_embryonic_growth_arrest1.95260342
22MP0000490_abnormal_crypts_of1.88459836
23MP0000350_abnormal_cell_proliferation1.88293817
24MP0001529_abnormal_vocalization1.79851168
25MP0006054_spinal_hemorrhage1.79589087
26MP0004808_abnormal_hematopoietic_stem1.75413709
27MP0003786_premature_aging1.75278643
28MP0003567_abnormal_fetal_cardiomyocyte1.68369784
29MP0002234_abnormal_pharynx_morphology1.66796278
30MP0005075_abnormal_melanosome_morpholog1.66229339
31MP0003763_abnormal_thymus_physiology1.61853122
32MP0005084_abnormal_gallbladder_morpholo1.61836331
33MP0000537_abnormal_urethra_morphology1.55551465
34MP0004147_increased_porphyrin_level1.51809298
35MP0008789_abnormal_olfactory_epithelium1.51232506
36MP0010307_abnormal_tumor_latency1.47015754
37MP0001346_abnormal_lacrimal_gland1.45334012
38MP0001697_abnormal_embryo_size1.44745001
39MP0010030_abnormal_orbit_morphology1.42328219
40MP0000631_abnormal_neuroendocrine_gland1.41788231
41MP0001672_abnormal_embryogenesis/_devel1.37532634
42MP0005380_embryogenesis_phenotype1.37532634
43MP0009333_abnormal_splenocyte_physiolog1.37446554
44MP0004197_abnormal_fetal_growth/weight/1.36188341
45MP0002080_prenatal_lethality1.34383522
46MP0003941_abnormal_skin_development1.32942348
47MP0002102_abnormal_ear_morphology1.31731847
48MP0006035_abnormal_mitochondrial_morpho1.31019144
49MP0002019_abnormal_tumor_incidence1.30522405
50MP0002086_abnormal_extraembryonic_tissu1.28052866
51MP0004142_abnormal_muscle_tone1.27471440
52MP0003315_abnormal_perineum_morphology1.27052058
53MP0003011_delayed_dark_adaptation1.26804318
54MP0002084_abnormal_developmental_patter1.26624367
55MP0002085_abnormal_embryonic_tissue1.26545574
56MP0003984_embryonic_growth_retardation1.25961555
57MP0002088_abnormal_embryonic_growth/wei1.24493683
58MP0000703_abnormal_thymus_morphology1.21891938
59MP0000313_abnormal_cell_death1.21888928
60MP0002398_abnormal_bone_marrow1.21274472
61MP0006036_abnormal_mitochondrial_physio1.21166033
62MP0005253_abnormal_eye_physiology1.21121049
63MP0001545_abnormal_hematopoietic_system1.17955534
64MP0005397_hematopoietic_system_phenotyp1.17955534
65MP0002277_abnormal_respiratory_mucosa1.13924746
66MP0010234_abnormal_vibrissa_follicle1.13801909
67MP0002722_abnormal_immune_system1.13744419
68MP0003938_abnormal_ear_development1.11901289
69MP0003283_abnormal_digestive_organ1.10726945
70MP0005551_abnormal_eye_electrophysiolog1.10473535
71MP0001485_abnormal_pinna_reflex1.08689237
72MP0005646_abnormal_pituitary_gland1.08015225
73MP0001293_anophthalmia1.07815491
74MP0002166_altered_tumor_susceptibility1.06244144
75MP0005023_abnormal_wound_healing1.06014453
76MP0000516_abnormal_urinary_system1.05856818
77MP0005367_renal/urinary_system_phenotyp1.05856818
78MP0000689_abnormal_spleen_morphology1.03754982
79MP0005408_hypopigmentation1.03609654
80MP0000465_gastrointestinal_hemorrhage1.02155647
81MP0003121_genomic_imprinting1.02034498
82MP0009053_abnormal_anal_canal1.01957846
83MP0003880_abnormal_central_pattern1.01587901
84MP0000049_abnormal_middle_ear1.00714180
85MP0002233_abnormal_nose_morphology0.99235300
86MP0003705_abnormal_hypodermis_morpholog0.98199820
87MP0005076_abnormal_cell_differentiation0.97975432
88MP0000685_abnormal_immune_system0.97585120
89MP0002697_abnormal_eye_size0.97445917
90MP0003566_abnormal_cell_adhesion0.97054440
91MP0005391_vision/eye_phenotype0.96595197
92MP0001764_abnormal_homeostasis0.96354568
93MP0001835_abnormal_antigen_presentation0.96015340
94MP0002160_abnormal_reproductive_system0.95683860
95MP0000858_altered_metastatic_potential0.95557425
96MP0002429_abnormal_blood_cell0.95346860
97MP0001929_abnormal_gametogenesis0.94677175
98MP0002751_abnormal_autonomic_nervous0.94122146
99MP0002132_abnormal_respiratory_system0.93174867
100MP0005501_abnormal_skin_physiology0.92682195
101MP0002837_dystrophic_cardiac_calcinosis0.92452755
102MP0005394_taste/olfaction_phenotype0.91581365
103MP0005499_abnormal_olfactory_system0.91581365
104MP0005377_hearing/vestibular/ear_phenot0.91228012
105MP0003878_abnormal_ear_physiology0.91228012
106MP0002006_tumorigenesis0.90261540
107MP0001800_abnormal_humoral_immune0.90066341
108MP0009278_abnormal_bone_marrow0.89772544
109MP0000653_abnormal_sex_gland0.89540443
110MP0008872_abnormal_physiological_respon0.89431850
111MP0002938_white_spotting0.88580251
112MP0008877_abnormal_DNA_methylation0.87287273
113MP0000716_abnormal_immune_system0.86217459
114MP0000477_abnormal_intestine_morphology0.86178585
115MP0000647_abnormal_sebaceous_gland0.85971592
116MP0010155_abnormal_intestine_physiology0.85575275
117MP0008875_abnormal_xenobiotic_pharmacok0.84628503
118MP0002638_abnormal_pupillary_reflex0.83574124
119MP0005174_abnormal_tail_pigmentation0.82399912
120MP0002111_abnormal_tail_morphology0.81342014
121MP0002420_abnormal_adaptive_immunity0.80646640
122MP0002095_abnormal_skin_pigmentation0.79956023
123MP0003718_maternal_effect0.79920428
124MP0005645_abnormal_hypothalamus_physiol0.78559637
125MP0001819_abnormal_immune_cell0.78417902
126MP0002452_abnormal_antigen_presenting0.78410903
127MP0001849_ear_inflammation0.78388324
128MP0001853_heart_inflammation0.78221541
129MP0001881_abnormal_mammary_gland0.78190753
130MP0002092_abnormal_eye_morphology0.77479585
131MP0002009_preneoplasia0.76699775
132MP0002736_abnormal_nociception_after0.76353537
133MP0001986_abnormal_taste_sensitivity0.75892863
134MP0005389_reproductive_system_phenotype0.75633731
135MP0002405_respiratory_system_inflammati0.75188355
136MP0001873_stomach_inflammation0.75010741
137MP0000383_abnormal_hair_follicle0.74187280
138MP0003937_abnormal_limbs/digits/tail_de0.73897185
139MP0005671_abnormal_response_to0.73624976
140MP0002282_abnormal_trachea_morphology0.73523545
141MP0006276_abnormal_autonomic_nervous0.73342015
142MP0001286_abnormal_eye_development0.72958407
143MP0001216_abnormal_epidermal_layer0.72583424
144MP0005195_abnormal_posterior_eye0.71638099
145MP0002210_abnormal_sex_determination0.70552552
146MP0002796_impaired_skin_barrier0.70370102
147MP0002877_abnormal_melanocyte_morpholog0.69827846
148MP0005171_absent_coat_pigmentation0.68798919
149MP0002060_abnormal_skin_morphology0.68275191
150MP0001915_intracranial_hemorrhage0.67967033
151MP0000377_abnormal_hair_follicle0.67708885
152MP0003119_abnormal_digestive_system0.66876376
153MP0003186_abnormal_redox_activity0.66357078
154MP0001324_abnormal_eye_pigmentation0.66153254
155MP0003890_abnormal_embryonic-extraembry0.65795965
156MP0009250_abnormal_appendicular_skeleto0.65447763
157MP0003806_abnormal_nucleotide_metabolis0.65416509
158MP0000026_abnormal_inner_ear0.64985261
159MP0001119_abnormal_female_reproductive0.64697675
160MP0000733_abnormal_muscle_development0.63505330
161MP0002723_abnormal_immune_serum0.63220548
162MP0001145_abnormal_male_reproductive0.63135655

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.81082220
2Reticulocytopenia (HP:0001896)6.42250291
3Abnormal number of erythroid precursors (HP:0012131)5.96914737
4Acute necrotizing encephalopathy (HP:0006965)4.97820335
5Increased hepatocellular lipid droplets (HP:0006565)4.56797797
6Mitochondrial inheritance (HP:0001427)4.50614403
7Abnormal mitochondria in muscle tissue (HP:0008316)4.41958834
8Macrocytic anemia (HP:0001972)4.39625076
9Acute encephalopathy (HP:0006846)4.38146537
10Progressive macrocephaly (HP:0004481)4.16578228
11Colon cancer (HP:0003003)4.13439838
12Pallor (HP:0000980)4.09810686
13Lipid accumulation in hepatocytes (HP:0006561)4.07254191
14Increased CSF lactate (HP:0002490)4.01006368
15Hepatocellular necrosis (HP:0001404)3.92976109
16Hepatic necrosis (HP:0002605)3.63643838
17Thrombocytosis (HP:0001894)3.55443754
183-Methylglutaconic aciduria (HP:0003535)3.54268484
19Cerebral edema (HP:0002181)3.36374934
20Renal Fanconi syndrome (HP:0001994)3.36320257
21Birth length less than 3rd percentile (HP:0003561)3.33700181
22Aplastic anemia (HP:0001915)3.18623062
23Selective tooth agenesis (HP:0001592)3.11303402
2411 pairs of ribs (HP:0000878)3.08904963
25Oral leukoplakia (HP:0002745)2.87582484
26Increased intramyocellular lipid droplets (HP:0012240)2.85710433
27Pancreatic cysts (HP:0001737)2.83487774
28Stenosis of the external auditory canal (HP:0000402)2.81531748
29Exertional dyspnea (HP:0002875)2.76397216
30Absent thumb (HP:0009777)2.68833152
31Septo-optic dysplasia (HP:0100842)2.68424075
32Optic disc pallor (HP:0000543)2.65814486
33Respiratory difficulties (HP:0002880)2.65651364
34Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.59510445
35Type I transferrin isoform profile (HP:0003642)2.57455834
36Trismus (HP:0000211)2.55684657
37Medulloblastoma (HP:0002885)2.55437825
38Increased serum lactate (HP:0002151)2.55083210
39Breast hypoplasia (HP:0003187)2.54680267
40Ependymoma (HP:0002888)2.52993027
41Lactic acidosis (HP:0003128)2.51504479
42Pancreatic fibrosis (HP:0100732)2.49980078
43Multiple enchondromatosis (HP:0005701)2.49648848
44True hermaphroditism (HP:0010459)2.48409290
45Leukodystrophy (HP:0002415)2.45770873
46Myelodysplasia (HP:0002863)2.41937960
47Rough bone trabeculation (HP:0100670)2.41882715
48Abnormality of midbrain morphology (HP:0002418)2.41374175
49Molar tooth sign on MRI (HP:0002419)2.41374175
50Basal cell carcinoma (HP:0002671)2.40166126
51Neoplasm of the pancreas (HP:0002894)2.37008648
52Decreased activity of mitochondrial respiratory chain (HP:0008972)2.36873416
53Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.36873416
54Aplasia/Hypoplasia of the sacrum (HP:0008517)2.35755317
55Abnormal hemoglobin (HP:0011902)2.31999625
56Respiratory failure (HP:0002878)2.31783612
57Glossoptosis (HP:0000162)2.29630297
58Nephronophthisis (HP:0000090)2.28690389
59Missing ribs (HP:0000921)2.28613359
60Agnosia (HP:0010524)2.27421241
61Patellar aplasia (HP:0006443)2.26247421
62Degeneration of anterior horn cells (HP:0002398)2.24302560
63Abnormality of the anterior horn cell (HP:0006802)2.24302560
64Carpal bone hypoplasia (HP:0001498)2.24075147
65Chromsome breakage (HP:0040012)2.23863958
66Exercise intolerance (HP:0003546)2.23112620
67Amaurosis fugax (HP:0100576)2.22586271
68Increased muscle lipid content (HP:0009058)2.22226036
69Abnormality of reticulocytes (HP:0004312)2.21663947
70IgM deficiency (HP:0002850)2.21339801
71Abnormality of renal resorption (HP:0011038)2.20742088
72Atresia of the external auditory canal (HP:0000413)2.20466522
73Abnormality of aspartate family amino acid metabolism (HP:0010899)2.18993600
74Proximal placement of thumb (HP:0009623)2.16694002
75Microretrognathia (HP:0000308)2.15654357
76Aplasia/Hypoplasia of the patella (HP:0006498)2.14863081
77Deviation of the thumb (HP:0009603)2.14751218
78Asplenia (HP:0001746)2.14003956
79Reduced antithrombin III activity (HP:0001976)2.13106823
80Congenital, generalized hypertrichosis (HP:0004540)2.11086093
81Abnormality of chromosome stability (HP:0003220)2.08252023
82Biliary tract neoplasm (HP:0100574)2.05476913
83Depressed nasal ridge (HP:0000457)2.04665814
84Abnormality of the preputium (HP:0100587)2.04201724
85Abnormality of methionine metabolism (HP:0010901)2.04042144
86Abnormality of urine glucose concentration (HP:0011016)2.04005938
87Glycosuria (HP:0003076)2.04005938
88Abnormal number of incisors (HP:0011064)2.02659520
89Aplasia/Hypoplasia of the spleen (HP:0010451)2.01171860
90Abnormal lung lobation (HP:0002101)1.98712177
91Lethargy (HP:0001254)1.98430409
92Microvesicular hepatic steatosis (HP:0001414)1.97899004
93Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.97826232
94Absent septum pellucidum (HP:0001331)1.97216916
95Partial duplication of thumb phalanx (HP:0009944)1.97207176
96Abnormality of the labia minora (HP:0012880)1.96120573
97Medial flaring of the eyebrow (HP:0010747)1.95624236
98Meckel diverticulum (HP:0002245)1.95496142
99Abnormality of the phalanges of the 2nd finger (HP:0009541)1.94823286
100Squamous cell carcinoma (HP:0002860)1.94730889
101Methylmalonic acidemia (HP:0002912)1.94046572
102Lymphoma (HP:0002665)1.93903987
103Neoplasm of the colon (HP:0100273)1.93311298
104Premature graying of hair (HP:0002216)1.92685931
105Bilateral microphthalmos (HP:0007633)1.91601300
106Rhabdomyosarcoma (HP:0002859)1.90809097
107Hypoplasia of the radius (HP:0002984)1.89504692
108Generalized aminoaciduria (HP:0002909)1.88915579
109Abnormality of the renal medulla (HP:0100957)1.87598683
110Abnormality of the parietal bone (HP:0002696)1.85793286
111Triphalangeal thumb (HP:0001199)1.85563919
112Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.85042550
113Abnormal protein N-linked glycosylation (HP:0012347)1.85042550
114Abnormal protein glycosylation (HP:0012346)1.85042550
115Abnormal glycosylation (HP:0012345)1.85042550
116Abnormality of the ileum (HP:0001549)1.83741362
117Poikiloderma (HP:0001029)1.82577647
118Hyperglycinuria (HP:0003108)1.82138124
119Cellular immunodeficiency (HP:0005374)1.81654806
120Abnormality of the septum pellucidum (HP:0007375)1.81605692
121Duodenal stenosis (HP:0100867)1.80410357
122Small intestinal stenosis (HP:0012848)1.80410357
123Chromosomal breakage induced by crosslinking agents (HP:0003221)1.78906191
124Sclerocornea (HP:0000647)1.78773965
125Absent radius (HP:0003974)1.78497801
126Hyperglycinemia (HP:0002154)1.78134741
127Renal cortical cysts (HP:0000803)1.77446336
128Abnormal biliary tract physiology (HP:0012439)1.77214216
129Bile duct proliferation (HP:0001408)1.77214216
130Thick lower lip vermilion (HP:0000179)1.76603501
131Single umbilical artery (HP:0001195)1.76186531
132Abnormality of the fetal cardiovascular system (HP:0010948)1.76186531
133Abnormal umbilical cord blood vessels (HP:0011403)1.76186531
134Hyperphosphaturia (HP:0003109)1.75596817
135Abnormality of the calcaneus (HP:0008364)1.75011395
136Partial duplication of the phalanx of hand (HP:0009999)1.73991349
137Abnormality of serum amino acid levels (HP:0003112)1.73605255
138Cleft eyelid (HP:0000625)1.72868399
139Tracheoesophageal fistula (HP:0002575)1.72415004
140Pancytopenia (HP:0001876)1.71829062
141Abnormal trabecular bone morphology (HP:0100671)1.70415728
142Type 2 muscle fiber atrophy (HP:0003554)1.69321444
143Abnormality of the pons (HP:0007361)1.68889942
144Concave nail (HP:0001598)1.68222955
145Bone marrow hypocellularity (HP:0005528)1.66579625
146Ovarian neoplasm (HP:0100615)1.66149304
147Abnormality of the renal cortex (HP:0011035)1.65582981
148Entropion (HP:0000621)1.64894077
149Optic nerve coloboma (HP:0000588)1.64745976
150Abnormality of the umbilical cord (HP:0010881)1.63805813
151Cutaneous melanoma (HP:0012056)1.63307339
152Aplasia involving forearm bones (HP:0009822)1.62599964
153Absent forearm bone (HP:0003953)1.62599964
154Horseshoe kidney (HP:0000085)1.62041799
155Supernumerary spleens (HP:0009799)1.61834743
156CNS demyelination (HP:0007305)1.61612489
157Optic nerve hypoplasia (HP:0000609)1.60397594
158Anophthalmia (HP:0000528)1.60389929
159Hypoplasia of the pons (HP:0012110)1.60315883
160Esophageal atresia (HP:0002032)1.58136511
161Aplasia/Hypoplasia of the uvula (HP:0010293)1.58114490
162Facial cleft (HP:0002006)1.57785354
163Woolly hair (HP:0002224)1.57135480
164Neoplasm of the rectum (HP:0100743)1.56931128
165Migraine (HP:0002076)1.55818154
166Blepharitis (HP:0000498)1.55124267
167Increased nuchal translucency (HP:0010880)1.55063743
168Sparse eyelashes (HP:0000653)1.54889434
169Premature ovarian failure (HP:0008209)1.53954579
170Short thumb (HP:0009778)1.53759477
171Bicuspid aortic valve (HP:0001647)1.53036357
172Sloping forehead (HP:0000340)1.52600099
173Cerebral hypomyelination (HP:0006808)1.51625471
174Recurrent bronchitis (HP:0002837)1.51460446
175Abnormality of T cells (HP:0002843)1.51244531
176Abnormality of the duodenum (HP:0002246)1.50958799

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.75593661
2WEE13.59365410
3BUB13.38243780
4NME23.38180071
5CDC73.11910350
6RPS6KB22.70817194
7PASK2.66495054
8CDK192.65312202
9EEF2K2.64047899
10TGFBR12.59154814
11EIF2AK12.43639299
12TSSK62.31129143
13SRPK12.29755015
14NEK22.15701062
15MKNK12.06196129
16ACVR1B1.95405713
17TAF11.90636064
18DYRK31.88322676
19LRRK21.77419512
20BRSK21.69670929
21RPS6KA41.66186869
22EIF2AK31.65104890
23PKN21.63946303
24AURKB1.62763410
25MST41.59703157
26TTK1.59131900
27VRK11.58006912
28MAP3K121.57178517
29TLK11.53801133
30MAP4K21.52125575
31EPHA21.50257680
32TAOK31.45040890
33BMPR1B1.45022092
34MAP4K11.44952897
35FLT31.44237066
36PLK11.42026379
37STK101.41900887
38WNK31.41390520
39CDK71.40427572
40ATR1.35905601
41BCKDK1.30209410
42PLK31.26178836
43PAK41.23886597
44MAP3K81.23049537
45NEK11.22570806
46MAP3K101.19976958
47CDK41.19440643
48STK161.15245188
49INSRR1.14785654
50MKNK21.14580915
51TESK21.11599508
52PIM11.06740184
53SCYL21.04933899
54GRK11.04875304
55STK41.03190652
56PLK41.02041549
57FGFR21.00948503
58DYRK20.99253514
59TRIM280.96464656
60CHEK10.95022513
61CDK60.93889700
62TNIK0.92438293
63PIM20.91848875
64CHEK20.90282776
65MAP2K30.89710864
66BTK0.86718611
67ADRBK20.86405136
68AURKA0.85652028
69ILK0.84973445
70CDK30.83800500
71BMPR20.82879454
72ALK0.81141241
73OXSR10.80944801
74MAP3K30.80895859
75MAPKAPK30.80726696
76PNCK0.80303097
77CDK120.79486323
78CSNK2A20.76329071
79TEC0.75590816
80ERBB30.74690702
81WNK40.74279330
82ZAP700.73272160
83TXK0.70812411
84ZAK0.69486417
85STK390.68650770
86ATM0.68425905
87EPHB20.66077068
88RPS6KA50.65977520
89MELK0.65153454
90CDK80.64508135
91PBK0.63102608
92JAK30.62958686
93KDR0.62438222
94BRSK10.62409682
95CSNK2A10.61635476
96CLK10.60325229
97CDK20.60286588
98PAK20.59661886
99TESK10.59143708
100STK38L0.58428421
101MAPKAPK50.58222980
102STK30.57375229
103MAPK150.53615312
104DAPK30.53283827
105PAK10.52530628
106FGFR10.52142797
107MUSK0.51739577
108PRKCI0.50582979
109NLK0.49397562
110TYK20.49235285
111IKBKB0.47909139
112GRK60.47879478
113CSF1R0.47430528
114EIF2AK20.46971976
115KIT0.46862262
116CSNK1G10.46810699
117TIE10.46003921
118CCNB10.43096766
119BRD40.42272819
120CSNK1G30.40705589
121NUAK10.39883659
122MAP3K40.39883278
123MATK0.39214279
124CDK10.38409702
125NME10.37784527
126ITK0.35991178
127MAP2K20.35519160
128CSNK1E0.35287546
129RPS6KL10.34472338
130RPS6KC10.34472338
131EPHA40.34461760
132MAPKAPK20.33843451
133RPS6KA60.33673167
134NEK90.33623753
135BLK0.33367911
136LCK0.32247923
137CSNK1G20.32192268
138LATS10.32104867
139TGFBR20.31452385
140CHUK0.31013962
141MYLK0.30567335
142PLK20.29813018
143DAPK10.26784145
144LYN0.25547370

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030105.50998618
2DNA replication_Homo sapiens_hsa030304.35455082
3Oxidative phosphorylation_Homo sapiens_hsa001904.28009632
4Mismatch repair_Homo sapiens_hsa034303.81260820
5Spliceosome_Homo sapiens_hsa030403.24722509
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.17090240
7Proteasome_Homo sapiens_hsa030503.11657511
8RNA polymerase_Homo sapiens_hsa030202.91675846
9RNA transport_Homo sapiens_hsa030132.80622286
10Nucleotide excision repair_Homo sapiens_hsa034202.65403783
11Base excision repair_Homo sapiens_hsa034102.64086642
12Homologous recombination_Homo sapiens_hsa034402.50587857
13Alzheimers disease_Homo sapiens_hsa050102.40138383
14Cell cycle_Homo sapiens_hsa041102.26567949
15One carbon pool by folate_Homo sapiens_hsa006702.21272342
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.20204768
17Pyrimidine metabolism_Homo sapiens_hsa002402.14595380
18Non-homologous end-joining_Homo sapiens_hsa034502.13296447
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.08765457
20Cardiac muscle contraction_Homo sapiens_hsa042601.73920166
21RNA degradation_Homo sapiens_hsa030181.70816780
22Fanconi anemia pathway_Homo sapiens_hsa034601.69777209
23Basal transcription factors_Homo sapiens_hsa030221.58854812
24mRNA surveillance pathway_Homo sapiens_hsa030151.53104109
25p53 signaling pathway_Homo sapiens_hsa041151.52313964
26Systemic lupus erythematosus_Homo sapiens_hsa053221.32761171
27Antigen processing and presentation_Homo sapiens_hsa046121.26957978
28Propanoate metabolism_Homo sapiens_hsa006401.25402565
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25316667
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22108410
31Epstein-Barr virus infection_Homo sapiens_hsa051691.21603008
32Protein export_Homo sapiens_hsa030601.08771479
33Primary immunodeficiency_Homo sapiens_hsa053401.08045084
34Herpes simplex infection_Homo sapiens_hsa051681.07166542
35Purine metabolism_Homo sapiens_hsa002301.06414658
36Viral carcinogenesis_Homo sapiens_hsa052031.02722992
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02212506
38Autoimmune thyroid disease_Homo sapiens_hsa053201.01457705
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00328364
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97146493
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90226849
42Graft-versus-host disease_Homo sapiens_hsa053320.89166964
43Cyanoamino acid metabolism_Homo sapiens_hsa004600.88646084
44Small cell lung cancer_Homo sapiens_hsa052220.88279596
45HTLV-I infection_Homo sapiens_hsa051660.88255731
46Type I diabetes mellitus_Homo sapiens_hsa049400.84873189
47Legionellosis_Homo sapiens_hsa051340.79137200
48Thyroid cancer_Homo sapiens_hsa052160.77572636
49Pyruvate metabolism_Homo sapiens_hsa006200.77009933
50Nitrogen metabolism_Homo sapiens_hsa009100.76247554
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76081590
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75292240
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74456504
54Phototransduction_Homo sapiens_hsa047440.73935800
55MicroRNAs in cancer_Homo sapiens_hsa052060.67218531
56Metabolic pathways_Homo sapiens_hsa011000.65511118
57Peroxisome_Homo sapiens_hsa041460.64525850
58Linoleic acid metabolism_Homo sapiens_hsa005910.63516275
59Measles_Homo sapiens_hsa051620.63257238
60Hematopoietic cell lineage_Homo sapiens_hsa046400.62949911
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.62757660
62Basal cell carcinoma_Homo sapiens_hsa052170.62712519
63Butanoate metabolism_Homo sapiens_hsa006500.61632094
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61504591
65Apoptosis_Homo sapiens_hsa042100.61306071
66Caffeine metabolism_Homo sapiens_hsa002320.58730210
67Fatty acid elongation_Homo sapiens_hsa000620.58240048
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56940725
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56497667
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56091517
71Chemical carcinogenesis_Homo sapiens_hsa052040.56035971
72TGF-beta signaling pathway_Homo sapiens_hsa043500.55908314
73Sulfur relay system_Homo sapiens_hsa041220.54812513
74Pentose phosphate pathway_Homo sapiens_hsa000300.53977020
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52373140
76Hippo signaling pathway_Homo sapiens_hsa043900.51398711
77Chronic myeloid leukemia_Homo sapiens_hsa052200.51375955
78Folate biosynthesis_Homo sapiens_hsa007900.50537738
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50027494
80Glutathione metabolism_Homo sapiens_hsa004800.49722107
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.49413931
82Huntingtons disease_Homo sapiens_hsa050160.48797508
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47827417
84Tryptophan metabolism_Homo sapiens_hsa003800.47710897
85Hepatitis B_Homo sapiens_hsa051610.47595939
86Notch signaling pathway_Homo sapiens_hsa043300.47417659
87Selenocompound metabolism_Homo sapiens_hsa004500.47414643
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.47149535
89Shigellosis_Homo sapiens_hsa051310.45551661
90Oocyte meiosis_Homo sapiens_hsa041140.44978768
91Viral myocarditis_Homo sapiens_hsa054160.44186966
92Colorectal cancer_Homo sapiens_hsa052100.44131136
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.44090077
94Regulation of autophagy_Homo sapiens_hsa041400.43989328
95Alcoholism_Homo sapiens_hsa050340.43957280
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43781933
97N-Glycan biosynthesis_Homo sapiens_hsa005100.43439228
98Vitamin digestion and absorption_Homo sapiens_hsa049770.42406924
99Pathways in cancer_Homo sapiens_hsa052000.42202879
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41798148
101Parkinsons disease_Homo sapiens_hsa050120.41613016
102Rheumatoid arthritis_Homo sapiens_hsa053230.41303264
103Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40587233
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.40371697
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40240191
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39275395
107Olfactory transduction_Homo sapiens_hsa047400.39218687
108Retinol metabolism_Homo sapiens_hsa008300.38292311
109Bladder cancer_Homo sapiens_hsa052190.37771125
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.37706201
111HIF-1 signaling pathway_Homo sapiens_hsa040660.36195593
112Influenza A_Homo sapiens_hsa051640.35989505
113Adherens junction_Homo sapiens_hsa045200.35563000
114Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35173752
115Collecting duct acid secretion_Homo sapiens_hsa049660.34857795
116Acute myeloid leukemia_Homo sapiens_hsa052210.34739194
117Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34433587
118Biosynthesis of amino acids_Homo sapiens_hsa012300.34334777
119Carbon metabolism_Homo sapiens_hsa012000.32975764
120B cell receptor signaling pathway_Homo sapiens_hsa046620.32493251
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31532986
122Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30478967
123Toxoplasmosis_Homo sapiens_hsa051450.30429170
124Hedgehog signaling pathway_Homo sapiens_hsa043400.30287678
125Allograft rejection_Homo sapiens_hsa053300.29980920
126Proteoglycans in cancer_Homo sapiens_hsa052050.29817579
127ECM-receptor interaction_Homo sapiens_hsa045120.29593627
128Cysteine and methionine metabolism_Homo sapiens_hsa002700.29223752
129T cell receptor signaling pathway_Homo sapiens_hsa046600.29090287
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.28922690
131Prostate cancer_Homo sapiens_hsa052150.28575322
132RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28554807
133Leishmaniasis_Homo sapiens_hsa051400.28402218
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28254629
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26401230
136AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.25707072
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.25536620
138Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.24974248
139Taste transduction_Homo sapiens_hsa047420.24355293
140Asthma_Homo sapiens_hsa053100.23566199
141Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19919798
142Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19746222
143Arachidonic acid metabolism_Homo sapiens_hsa005900.19380925
144Tyrosine metabolism_Homo sapiens_hsa003500.19187763
145Tight junction_Homo sapiens_hsa045300.19123086
146Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18772119
147Ether lipid metabolism_Homo sapiens_hsa005650.18422340
148Fatty acid degradation_Homo sapiens_hsa000710.14722695
149Primary bile acid biosynthesis_Homo sapiens_hsa001200.14199193
150beta-Alanine metabolism_Homo sapiens_hsa004100.13400419
151SNARE interactions in vesicular transport_Homo sapiens_hsa041300.13134753
152Fat digestion and absorption_Homo sapiens_hsa049750.12142419

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