ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	8.64732581
2	translational termination (GO:0006415)	8.31516959
3	ribosomal small subunit biogenesis (GO:0042274)	7.13481469
4	maturation of SSU-rRNA (GO:0030490)	6.92815492
5	ribosomal small subunit assembly (GO:0000028)	6.87314022
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.79926867
7	translational elongation (GO:0006414)	6.73016789
8	cotranslational protein targeting to membrane (GO:0006613)	6.63214303
9	protein targeting to ER (GO:0045047)	6.59650225
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.37373509
11	cellular protein complex disassembly (GO:0043624)	6.36667815
12	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	6.22374108
13	behavioral response to nicotine (GO:0035095)	6.19092917
14	viral life cycle (GO:0019058)	6.16714424
15	protein localization to endoplasmic reticulum (GO:0070972)	6.15363997
16	protein complex disassembly (GO:0043241)	5.59291590
17	translational initiation (GO:0006413)	5.37220846
18	macromolecular complex disassembly (GO:0032984)	5.25445048
19	cell proliferation in forebrain (GO:0021846)	5.07795349
20	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.44222582
21	ribosomal large subunit biogenesis (GO:0042273)	4.28184381
22	protein targeting to membrane (GO:0006612)	4.24834971
23	mRNA catabolic process (GO:0006402)	4.23904688
24	GTP biosynthetic process (GO:0006183)	4.08684294
25	ribonucleoprotein complex biogenesis (GO:0022613)	3.93687023
26	translation (GO:0006412)	3.93099568
27	protein neddylation (GO:0045116)	3.84087885
28	RNA catabolic process (GO:0006401)	3.82370880
29	UTP biosynthetic process (GO:0006228)	3.74354712
30	spinal cord association neuron differentiation (GO:0021527)	3.73353369
31	UTP metabolic process (GO:0046051)	3.67945251
32	head development (GO:0060322)	3.51295111
33	CTP metabolic process (GO:0046036)	3.47808963
34	CTP biosynthetic process (GO:0006241)	3.47808963
35	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.44044639
36	chaperone-mediated protein transport (GO:0072321)	3.42821069
37	somite development (GO:0061053)	3.42575645
38	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.40051560
39	cellular component biogenesis (GO:0044085)	3.35045680
40	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.32938191
41	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.32424947
42	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.32424947
43	NADH dehydrogenase complex assembly (GO:0010257)	3.32424947
44	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.30307315
45	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.26397339
46	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.25775536
47	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	3.24198651
48	pyrimidine nucleobase catabolic process (GO:0006208)	3.21334459
49	cardiovascular system development (GO:0072358)	3.14229468
50	rRNA catabolic process (GO:0016075)	3.12214200
51	positive regulation of interferon-gamma biosynthetic process (GO:0045078)	3.08904490
52	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.06724619
53	myoblast migration (GO:0051451)	3.03816878
54	positive regulation by host of viral transcription (GO:0043923)	3.01976353
55	ATP synthesis coupled proton transport (GO:0015986)	2.98540067
56	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.98540067
57	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.95762995
58	olfactory bulb development (GO:0021772)	2.92929472
59	tongue development (GO:0043586)	2.90582035
60	genetic imprinting (GO:0071514)	2.89932700
61	kidney morphogenesis (GO:0060993)	2.87136039
62	rRNA metabolic process (GO:0016072)	2.86421667
63	rRNA processing (GO:0006364)	2.85699012
64	auditory receptor cell differentiation (GO:0042491)	2.84398304
65	neuron fate determination (GO:0048664)	2.77024421
66	positive regulation of T cell apoptotic process (GO:0070234)	2.76476848
67	endoderm formation (GO:0001706)	2.76079662
68	lens fiber cell development (GO:0070307)	2.75921730
69	ribosome biogenesis (GO:0042254)	2.75635417
70	meiotic chromosome segregation (GO:0045132)	2.75442551
71	establishment of protein localization to membrane (GO:0090150)	2.74303866
72	establishment of protein localization to organelle (GO:0072594)	2.74114937
73	replicative senescence (GO:0090399)	2.74027056
74	ncRNA catabolic process (GO:0034661)	2.73989010
75	collecting duct development (GO:0072044)	2.71807726
76	pyrimidine nucleotide catabolic process (GO:0006244)	2.70193530
77	protein complex biogenesis (GO:0070271)	2.68548940
78	hypothalamus development (GO:0021854)	2.67794588
79	histone H3-K4 trimethylation (GO:0080182)	2.66397921
80	resolution of meiotic recombination intermediates (GO:0000712)	2.66307872
81	protein targeting (GO:0006605)	2.66186409
82	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.62704107
83	positive regulation of cell fate commitment (GO:0010455)	2.62576282
84	intraciliary transport (GO:0042073)	2.59575146
85	chromatin remodeling at centromere (GO:0031055)	2.59466053
86	interferon-gamma production (GO:0032609)	2.57321689
87	mitochondrial respiratory chain complex assembly (GO:0033108)	2.55016533
88	regulation of centriole replication (GO:0046599)	2.54706574
89	synaptic transmission, cholinergic (GO:0007271)	2.49858402
90	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	2.48264162
91	axon ensheathment in central nervous system (GO:0032291)	2.47424516
92	central nervous system myelination (GO:0022010)	2.47424516
93	pattern specification involved in kidney development (GO:0061004)	2.46814945
94	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.44211436
95	water-soluble vitamin biosynthetic process (GO:0042364)	2.43195221
96	transmission of nerve impulse (GO:0019226)	2.38464130
97	nucleobase catabolic process (GO:0046113)	2.38126339
98	protein polyglutamylation (GO:0018095)	2.36734548
99	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.36034211
100	substrate-independent telencephalic tangential migration (GO:0021826)	2.36034211

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.89088663
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.73956212
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.70131859
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.25178207
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.76701184
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.76592327
7	IRF1_19129219_ChIP-ChIP_H3396_Human	2.72815859
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.66640864
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.54264396
10	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.53566298
11	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.53251063
12	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.44364553
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.26347493
14	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.20722809
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.15187435
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.05232090
17	TTF2_22483619_ChIP-Seq_HELA_Human	1.97944354
18	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.93078359
19	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.88401194
20	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.75649689
21	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.75145675
22	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.74980933
23	XRN2_22483619_ChIP-Seq_HELA_Human	1.71972640
24	VDR_22108803_ChIP-Seq_LS180_Human	1.70080417
25	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.69153384
26	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.66406878
27	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.64437162
28	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.61983857
29	FOXP3_21729870_ChIP-Seq_TREG_Human	1.61543714
30	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.60196879
31	MYC_18940864_ChIP-ChIP_HL60_Human	1.59267010
32	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.58793538
33	VDR_23849224_ChIP-Seq_CD4+_Human	1.57634207
34	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.53599066
35	EWS_26573619_Chip-Seq_HEK293_Human	1.52407309
36	GABP_19822575_ChIP-Seq_HepG2_Human	1.45372545
37	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.44068993
38	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.42822499
39	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.40830769
40	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.39431028
41	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.39357203
42	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.38339665
43	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.37891147
44	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.37251212
45	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.37107432
46	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.32258590
47	REST_21632747_ChIP-Seq_MESCs_Mouse	1.27709753
48	ELK1_19687146_ChIP-ChIP_HELA_Human	1.26754658
49	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.25271120
50	E2F7_22180533_ChIP-Seq_HELA_Human	1.21625163
51	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.19300046
52	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.17295594
53	IGF1R_20145208_ChIP-Seq_DFB_Human	1.16453067
54	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.15748433
55	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.14332304
56	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.12637775
57	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.12502304
58	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.11159774
59	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.10343681
60	RNF2_27304074_Chip-Seq_NSC_Mouse	1.09765574
61	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.09603148
62	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.09088001
63	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.08818045
64	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.07598123
65	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.07505646
66	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.06935252
67	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.05919763
68	KDM5A_27292631_Chip-Seq_BREAST_Human	1.05094731
69	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.04890244
70	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.02558424
71	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.02203246
72	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.01296393
73	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.99882810
74	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.97865023
75	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.95141161
76	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.95077079
77	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94375822
78	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.94375822
79	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.93796680
80	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.91962955
81	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.91211627
82	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.90432925
83	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.90114084
84	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.89839354
85	P53_21459846_ChIP-Seq_SAOS-2_Human	0.88806317
86	CIITA_25753668_ChIP-Seq_RAJI_Human	0.86308042
87	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.86269375
88	ERA_21632823_ChIP-Seq_H3396_Human	0.85800788
89	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.85668861
90	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.84963566
91	TP53_22573176_ChIP-Seq_HFKS_Human	0.83149634
92	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.82931433
93	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.82569300
94	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.81767067
95	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.79371224
96	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.79371224
97	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.79023265
98	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.78056315
99	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.77674685
100	P68_20966046_ChIP-Seq_HELA_Human	0.76986199

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	5.43165412
2	MP0009379_abnormal_foot_pigmentation	5.30423236
3	MP0003122_maternal_imprinting	4.15065349
4	MP0002163_abnormal_gland_morphology	3.45931651
5	MP0003787_abnormal_imprinting	3.13763326
6	MP0003121_genomic_imprinting	2.74373660
7	MP0004142_abnormal_muscle_tone	2.63552694
8	MP0003890_abnormal_embryonic-extraembry	2.55873149
9	MP0001293_anophthalmia	2.44890850
10	MP0002653_abnormal_ependyma_morphology	2.28360790
11	MP0008877_abnormal_DNA_methylation	2.16698758
12	MP0002102_abnormal_ear_morphology	2.15686164
13	MP0000778_abnormal_nervous_system	2.10817603
14	MP0010030_abnormal_orbit_morphology	2.07004141
15	MP0004742_abnormal_vestibular_system	2.01476931
16	MP0008789_abnormal_olfactory_epithelium	1.96626952
17	MP0003123_paternal_imprinting	1.93370461
18	MP0000049_abnormal_middle_ear	1.79438332
19	MP0003693_abnormal_embryo_hatching	1.79097507
20	MP0001348_abnormal_lacrimal_gland	1.75701769
21	MP0005394_taste/olfaction_phenotype	1.75611970
22	MP0005499_abnormal_olfactory_system	1.75611970
23	MP0003646_muscle_fatigue	1.71894246
24	MP0001485_abnormal_pinna_reflex	1.71022605
25	MP0001286_abnormal_eye_development	1.58381051
26	MP0005379_endocrine/exocrine_gland_phen	1.57268233
27	MP0000631_abnormal_neuroendocrine_gland	1.56677259
28	MP0004145_abnormal_muscle_electrophysio	1.51730477
29	MP0008057_abnormal_DNA_replication	1.40607705
30	MP0008995_early_reproductive_senescence	1.40456285
31	MP0000685_abnormal_immune_system	1.35904448
32	MP0003567_abnormal_fetal_cardiomyocyte	1.31032802
33	MP0006276_abnormal_autonomic_nervous	1.29926326
34	MP0001986_abnormal_taste_sensitivity	1.27749274
35	MP0001873_stomach_inflammation	1.26292472
36	MP0005646_abnormal_pituitary_gland	1.25247511
37	MP0004133_heterotaxia	1.23468738
38	MP0002938_white_spotting	1.21415445
39	MP0000569_abnormal_digit_pigmentation	1.19194810
40	MP0005377_hearing/vestibular/ear_phenot	1.16229170
41	MP0003878_abnormal_ear_physiology	1.16229170
42	MP0002138_abnormal_hepatobiliary_system	1.13490306
43	MP0005645_abnormal_hypothalamus_physiol	1.13050254
44	MP0000955_abnormal_spinal_cord	1.12855806
45	MP0001663_abnormal_digestive_system	1.10795106
46	MP0005195_abnormal_posterior_eye	1.10508320
47	MP0003937_abnormal_limbs/digits/tail_de	1.07435936
48	MP0001440_abnormal_grooming_behavior	1.07414407
49	MP0005387_immune_system_phenotype	1.05994015
50	MP0001790_abnormal_immune_system	1.05994015
51	MP0000427_abnormal_hair_cycle	1.04423111
52	MP0002160_abnormal_reproductive_system	1.03920504
53	MP0005423_abnormal_somatic_nervous	1.02846202
54	MP0002210_abnormal_sex_determination	1.01703221
55	MP0000372_irregular_coat_pigmentation	1.00511311
56	MP0002234_abnormal_pharynx_morphology	0.98765744
57	MP0002092_abnormal_eye_morphology	0.97801477
58	MP0001529_abnormal_vocalization	0.96909065
59	MP0002557_abnormal_social/conspecific_i	0.95203953
60	MP0002928_abnormal_bile_duct	0.92374669
61	MP0003942_abnormal_urinary_system	0.90993724
62	MP0002752_abnormal_somatic_nervous	0.88068722
63	MP0005389_reproductive_system_phenotype	0.86802115
64	MP0008872_abnormal_physiological_respon	0.86114295
65	MP0002184_abnormal_innervation	0.85046298
66	MP0003786_premature_aging	0.84789621
67	MP0002116_abnormal_craniofacial_bone	0.84473311
68	MP0001835_abnormal_antigen_presentation	0.84426093
69	MP0003936_abnormal_reproductive_system	0.84225292
70	MP0002233_abnormal_nose_morphology	0.83354271
71	MP0002736_abnormal_nociception_after	0.82485869
72	MP0000026_abnormal_inner_ear	0.81601638
73	MP0001968_abnormal_touch/_nociception	0.81146146
74	MP0004130_abnormal_muscle_cell	0.80270217
75	MP0002152_abnormal_brain_morphology	0.79694048
76	MP0003861_abnormal_nervous_system	0.78730277
77	MP0001919_abnormal_reproductive_system	0.77516775
78	MP0002733_abnormal_thermal_nociception	0.77337818
79	MP0001800_abnormal_humoral_immune	0.75998327
80	MP0004885_abnormal_endolymph	0.75899589
81	MP0002095_abnormal_skin_pigmentation	0.75164392
82	MP0005671_abnormal_response_to	0.74414138
83	MP0005391_vision/eye_phenotype	0.71369315
84	MP0002272_abnormal_nervous_system	0.71266349
85	MP0002063_abnormal_learning/memory/cond	0.69504470
86	MP0004957_abnormal_blastocyst_morpholog	0.69054672
87	MP0003938_abnormal_ear_development	0.67311909
88	MP0009250_abnormal_appendicular_skeleto	0.67288850
89	MP0009053_abnormal_anal_canal	0.67229694
90	MP0002067_abnormal_sensory_capabilities	0.66615264
91	MP0001963_abnormal_hearing_physiology	0.65797797
92	MP0002697_abnormal_eye_size	0.65070734
93	MP0009046_muscle_twitch	0.62492049
94	MP0001119_abnormal_female_reproductive	0.61292578
95	MP0002638_abnormal_pupillary_reflex	0.60641517
96	MP0003136_yellow_coat_color	0.60406212
97	MP0002882_abnormal_neuron_morphology	0.60159689
98	MP0005084_abnormal_gallbladder_morpholo	0.59881500
99	MP0002109_abnormal_limb_morphology	0.57531003
100	MP0003959_abnormal_lean_body	0.57046253

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	6.10932484
2	Abnormality of cells of the erythroid lineage (HP:0012130)	5.50665051
3	Abnormal number of erythroid precursors (HP:0012131)	4.04592659
4	Septo-optic dysplasia (HP:0100842)	4.01570974
5	Macrocytic anemia (HP:0001972)	3.92719209
6	Pancreatic fibrosis (HP:0100732)	3.75018200
7	Pallor (HP:0000980)	3.46859814
8	True hermaphroditism (HP:0010459)	3.21287906
9	Pancreatic cysts (HP:0001737)	3.19786025
10	Abnormality of the labia minora (HP:0012880)	3.11978758
11	Molar tooth sign on MRI (HP:0002419)	3.06191579
12	Abnormality of midbrain morphology (HP:0002418)	3.06191579
13	Stomatitis (HP:0010280)	3.00149800
14	Tubular atrophy (HP:0000092)	2.91406642
15	Colon cancer (HP:0003003)	2.85877718
16	Nephronophthisis (HP:0000090)	2.79441854
17	Growth hormone deficiency (HP:0000824)	2.77884766
18	Adrenal hypoplasia (HP:0000835)	2.75383507
19	Pendular nystagmus (HP:0012043)	2.58589300
20	Absent thumb (HP:0009777)	2.57069237
21	Chronic hepatic failure (HP:0100626)	2.57049365
22	Absent septum pellucidum (HP:0001331)	2.55781457
23	Increased IgM level (HP:0003496)	2.50921670
24	Stenosis of the external auditory canal (HP:0000402)	2.46955439
25	Abnormal hair whorl (HP:0010721)	2.45731273
26	Sclerocornea (HP:0000647)	2.45309299
27	Ectopic kidney (HP:0000086)	2.43741136
28	Depressed nasal ridge (HP:0000457)	2.41426179
29	Acute necrotizing encephalopathy (HP:0006965)	2.36986999
30	Abnormality of the corticospinal tract (HP:0002492)	2.34738525
31	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.32939133
32	Cystic liver disease (HP:0006706)	2.32355083
33	Asplenia (HP:0001746)	2.31147191
34	11 pairs of ribs (HP:0000878)	2.31035970
35	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.30977326
36	Severe visual impairment (HP:0001141)	2.28501386
37	Anencephaly (HP:0002323)	2.25853871
38	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.24728623
39	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.24728623
40	Oligodactyly (hands) (HP:0001180)	2.23724739
41	Polydipsia (HP:0001959)	2.22720638
42	Abnormal drinking behavior (HP:0030082)	2.22720638
43	Rib fusion (HP:0000902)	2.22450619
44	Deep palmar crease (HP:0006191)	2.21147939
45	Abnormality of the incisor (HP:0000676)	2.20113313
46	Type II lissencephaly (HP:0007260)	2.19477205
47	Abnormality of the renal medulla (HP:0100957)	2.17008400
48	Abnormal hemoglobin (HP:0011902)	2.11496095
49	Mitochondrial inheritance (HP:0001427)	2.11263413
50	Abnormality of DNA repair (HP:0003254)	2.08768829
51	Abnormal rod and cone electroretinograms (HP:0008323)	2.08507063
52	Hyperthyroidism (HP:0000836)	2.08493464
53	Congenital stationary night blindness (HP:0007642)	2.08295349
54	High anterior hairline (HP:0009890)	2.06625930
55	Abnormal number of incisors (HP:0011064)	2.06254257
56	Postaxial foot polydactyly (HP:0001830)	2.05459537
57	Abnormality of incisor morphology (HP:0011063)	2.02205112
58	Acute encephalopathy (HP:0006846)	2.02154655
59	Abnormality of the septum pellucidum (HP:0007375)	2.01662104
60	Submucous cleft hard palate (HP:0000176)	2.00947984
61	Holoprosencephaly (HP:0001360)	2.00396827
62	Diastasis recti (HP:0001540)	2.00117602
63	Anophthalmia (HP:0000528)	1.99147681
64	Optic nerve hypoplasia (HP:0000609)	1.98671445
65	Increased CSF lactate (HP:0002490)	1.98181833
66	Lipid accumulation in hepatocytes (HP:0006561)	1.97857352
67	Thyroid-stimulating hormone excess (HP:0002925)	1.97702381
68	Polyuria (HP:0000103)	1.96964985
69	Abnormality of the nasal septum (HP:0000419)	1.96465693
70	Abnormal mitochondria in muscle tissue (HP:0008316)	1.94995098
71	Abnormality of reticulocytes (HP:0004312)	1.93109350
72	Optic nerve coloboma (HP:0000588)	1.92384780
73	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.91598508
74	Hypoplasia of the radius (HP:0002984)	1.88310409
75	Decreased central vision (HP:0007663)	1.87446476
76	Patellar aplasia (HP:0006443)	1.87000421
77	Abnormality of the renal cortex (HP:0011035)	1.86880143
78	Aplasia/Hypoplasia of the patella (HP:0006498)	1.85693826
79	Oligodactyly (HP:0012165)	1.85394091
80	Congenital hepatic fibrosis (HP:0002612)	1.85129866
81	Neoplasm of the adrenal cortex (HP:0100641)	1.85068861
82	Porencephaly (HP:0002132)	1.83193827
83	Increased hepatocellular lipid droplets (HP:0006565)	1.83039345
84	Small hand (HP:0200055)	1.82777383
85	Abnormality of the aortic arch (HP:0012303)	1.82375075
86	Dandy-Walker malformation (HP:0001305)	1.81954026
87	Male pseudohermaphroditism (HP:0000037)	1.81351606
88	Optic disc pallor (HP:0000543)	1.77675414
89	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.76847850
90	Neutropenia (HP:0001875)	1.76060191
91	Hip dysplasia (HP:0001385)	1.75640611
92	Maternal diabetes (HP:0009800)	1.74245420
93	Genetic anticipation (HP:0003743)	1.73686467
94	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.72796177
95	Agitation (HP:0000713)	1.71846393
96	Triphalangeal thumb (HP:0001199)	1.70649329
97	Supernumerary spleens (HP:0009799)	1.68369759
98	Progressive macrocephaly (HP:0004481)	1.67587317
99	Medial flaring of the eyebrow (HP:0010747)	1.67273527
100	Respiratory difficulties (HP:0002880)	1.66348278

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	3.01556581
2	NUAK1	2.75442745
3	ZAK	2.73030912
4	TLK1	2.56783734
5	CDC7	2.52140117
6	ICK	2.31980511
7	FRK	2.29927739
8	WNK3	2.16307092
9	TXK	2.15874274
10	CAMKK2	2.08696249
11	DYRK2	1.95848773
12	SIK2	1.87296195
13	PRKD3	1.84951064
14	TIE1	1.78702170
15	PASK	1.76014588
16	CAMK1D	1.70690635
17	DYRK1B	1.65667712
18	EPHB2	1.65486895
19	WNK1	1.62951199
20	BMPR1B	1.62768473
21	TEC	1.59412313
22	BTK	1.56609532
23	ADRBK2	1.55903769
24	GRK1	1.54812316
25	TAF1	1.53903226
26	CDK19	1.49522629
27	CAMKK1	1.49469852
28	DYRK3	1.47273229
29	PIK3CA	1.45120993
30	TYRO3	1.39664556
31	LRRK2	1.37282045
32	MAP3K11	1.28204574
33	ITK	1.25064028
34	STK11	1.24935875
35	NEK1	1.24888202
36	PAK3	1.24452578
37	NEK2	1.21007752
38	MKNK2	1.18732374
39	DMPK	1.17923533
40	CDK8	1.16470267
41	CAMK1G	1.15476839
42	MAP3K10	1.11806076
43	SGK494	1.08122982
44	SGK223	1.08122982
45	NTRK2	1.07205893
46	MAPK15	1.05885261
47	CAMK4	1.04249865
48	CAMK1	1.00522457
49	AURKB	0.96670337
50	MARK2	0.95759411
51	STK39	0.94513814
52	MAP4K1	0.93812954
53	TGFBR1	0.93474715
54	BCKDK	0.92163245
55	RPS6KA6	0.87825275
56	DAPK3	0.84112071
57	PLK2	0.82217854
58	NME1	0.80757362
59	AKT3	0.80439512
60	PRKCQ	0.79838496
61	PLK4	0.77596361
62	ATR	0.76748676
63	SGK2	0.72856832
64	SGK1	0.72011895
65	ALK	0.70072517
66	RPS6KL1	0.69633457
67	RPS6KC1	0.69633457
68	CHEK1	0.69232660
69	PRKCH	0.69002601
70	DYRK1A	0.68380782
71	STK16	0.67649595
72	CDK3	0.66386483
73	ADRBK1	0.63312378
74	CHEK2	0.60022023
75	SYK	0.59700231
76	MAP3K12	0.57397233
77	PRKCZ	0.55016211
78	CSNK2A2	0.54434558
79	MAP3K7	0.54304706
80	CSNK1E	0.52953485
81	CDK7	0.50072619
82	TRIM28	0.49590913
83	AKT1	0.49553476
84	KIT	0.49544737
85	PRKCG	0.48460633
86	PRKAA2	0.47564041
87	MKNK1	0.47030257
88	RPS6KB2	0.46282760
89	RPS6KA4	0.46077891
90	KSR1	0.45859159
91	AURKA	0.45474688
92	PIM1	0.44288680
93	PRKACA	0.43649994
94	PINK1	0.40427280
95	VRK2	0.40287751
96	RPS6KA1	0.39928423
97	PRKAA1	0.38736098
98	UHMK1	0.38382237
99	NME2	0.37423923
100	MAP2K2	0.37154340

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.96724711
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.86447174
3	Parkinsons disease_Homo sapiens_hsa05012	2.62553646
4	Sulfur relay system_Homo sapiens_hsa04122	2.53483174
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.24000007
6	RNA degradation_Homo sapiens_hsa03018	2.18256670
7	One carbon pool by folate_Homo sapiens_hsa00670	2.15432686
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.12435923
9	Huntingtons disease_Homo sapiens_hsa05016	2.07081679
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.06856505
11	RNA polymerase_Homo sapiens_hsa03020	2.05429078
12	Fanconi anemia pathway_Homo sapiens_hsa03460	1.95201807
13	Basal transcription factors_Homo sapiens_hsa03022	1.94394626
14	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.87975107
15	Cardiac muscle contraction_Homo sapiens_hsa04260	1.86002781
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.81681135
17	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.77636546
18	Protein export_Homo sapiens_hsa03060	1.72507255
19	Alzheimers disease_Homo sapiens_hsa05010	1.67597040
20	Nucleotide excision repair_Homo sapiens_hsa03420	1.60435679
21	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.57980911
22	Basal cell carcinoma_Homo sapiens_hsa05217	1.57222961
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.56407908
24	Homologous recombination_Homo sapiens_hsa03440	1.53616366
25	Pyrimidine metabolism_Homo sapiens_hsa00240	1.43391971
26	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.37047732
27	DNA replication_Homo sapiens_hsa03030	1.36376061
28	Butanoate metabolism_Homo sapiens_hsa00650	1.23424261
29	RNA transport_Homo sapiens_hsa03013	1.22666073
30	Mismatch repair_Homo sapiens_hsa03430	1.20459430
31	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.18480386
32	Asthma_Homo sapiens_hsa05310	1.14864473
33	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.13799073
34	Notch signaling pathway_Homo sapiens_hsa04330	1.08941360
35	Spliceosome_Homo sapiens_hsa03040	1.06832703
36	Primary immunodeficiency_Homo sapiens_hsa05340	1.00012052
37	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.97798240
38	Proteasome_Homo sapiens_hsa03050	0.94811565
39	Base excision repair_Homo sapiens_hsa03410	0.94062092
40	Allograft rejection_Homo sapiens_hsa05330	0.93944910
41	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.92689807
42	Steroid biosynthesis_Homo sapiens_hsa00100	0.88322738
43	Ether lipid metabolism_Homo sapiens_hsa00565	0.88251381
44	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.82136588
45	Folate biosynthesis_Homo sapiens_hsa00790	0.81498045
46	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.80620406
47	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.79289083
48	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.76199740
49	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.73554060
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.72280005
51	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.68561967
52	Lysine degradation_Homo sapiens_hsa00310	0.67512055
53	Fat digestion and absorption_Homo sapiens_hsa04975	0.67208328
54	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.66606120
55	mRNA surveillance pathway_Homo sapiens_hsa03015	0.66270954
56	Nicotine addiction_Homo sapiens_hsa05033	0.63012045
57	Phototransduction_Homo sapiens_hsa04744	0.62802073
58	Purine metabolism_Homo sapiens_hsa00230	0.62429418
59	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.57353382
60	Fatty acid degradation_Homo sapiens_hsa00071	0.52837150
61	Wnt signaling pathway_Homo sapiens_hsa04310	0.52833074
62	Propanoate metabolism_Homo sapiens_hsa00640	0.52720930
63	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.51572597
64	Regulation of autophagy_Homo sapiens_hsa04140	0.51390863
65	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.51180326
66	Cholinergic synapse_Homo sapiens_hsa04725	0.48796026
67	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.47570467
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.46646520
69	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.45578630
70	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.45321628
71	Morphine addiction_Homo sapiens_hsa05032	0.44910619
72	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.44471307
73	Axon guidance_Homo sapiens_hsa04360	0.42274411
74	p53 signaling pathway_Homo sapiens_hsa04115	0.41790730
75	Cell cycle_Homo sapiens_hsa04110	0.40961239
76	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.40040395
77	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.40007661
78	Ras signaling pathway_Homo sapiens_hsa04014	0.38643636
79	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.38533958
80	Alcoholism_Homo sapiens_hsa05034	0.36294662
81	Olfactory transduction_Homo sapiens_hsa04740	0.35782113
82	Retinol metabolism_Homo sapiens_hsa00830	0.35332906
83	Peroxisome_Homo sapiens_hsa04146	0.35151435
84	Taste transduction_Homo sapiens_hsa04742	0.34129567
85	Metabolic pathways_Homo sapiens_hsa01100	0.33058746
86	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.32676812
87	HTLV-I infection_Homo sapiens_hsa05166	0.32418022
88	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.30593611
89	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.29458077
90	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.29394457
91	Melanoma_Homo sapiens_hsa05218	0.27233642
92	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.27171594
93	Fatty acid metabolism_Homo sapiens_hsa01212	0.26460749
94	Chemical carcinogenesis_Homo sapiens_hsa05204	0.24535552
95	VEGF signaling pathway_Homo sapiens_hsa04370	0.23285601
96	Hippo signaling pathway_Homo sapiens_hsa04390	0.23221932
97	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.23216623
98	Glutamatergic synapse_Homo sapiens_hsa04724	0.22989438
99	Colorectal cancer_Homo sapiens_hsa05210	0.22465233
100	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.21613540

RPL7AP10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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