ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	5.39543996
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.86628998
3	ATP synthesis coupled proton transport (GO:0015986)	4.86628998
4	viral transcription (GO:0019083)	4.75860056
5	chaperone-mediated protein transport (GO:0072321)	4.73831142
6	DNA deamination (GO:0045006)	4.73081084
7	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.72831990
8	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.72831990
9	NADH dehydrogenase complex assembly (GO:0010257)	4.72831990
10	protein neddylation (GO:0045116)	4.66529090
11	translational termination (GO:0006415)	4.60385514
12	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.57835251
13	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.55822659
14	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.36730986
15	protein complex biogenesis (GO:0070271)	4.35646044
16	maturation of SSU-rRNA (GO:0030490)	4.24492267
17	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.15438265
18	cotranslational protein targeting to membrane (GO:0006613)	4.09940879
19	translational elongation (GO:0006414)	4.09878068
20	protein targeting to ER (GO:0045047)	4.06365682
21	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.03063168
22	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.03063168
23	mitochondrial respiratory chain complex assembly (GO:0033108)	3.98127587
24	ribosomal small subunit biogenesis (GO:0042274)	3.96721521
25	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.86521179
26	protein localization to endoplasmic reticulum (GO:0070972)	3.81213565
27	ribosomal large subunit biogenesis (GO:0042273)	3.63435282
28	respiratory electron transport chain (GO:0022904)	3.62405686
29	electron transport chain (GO:0022900)	3.61733588
30	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.57374814
31	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.48795886
32	behavioral response to nicotine (GO:0035095)	3.45914908
33	viral life cycle (GO:0019058)	3.41679406
34	GTP biosynthetic process (GO:0006183)	3.41289716
35	cellular protein complex disassembly (GO:0043624)	3.41113237
36	translational initiation (GO:0006413)	3.38312516
37	water-soluble vitamin biosynthetic process (GO:0042364)	3.37668865
38	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.35797417
39	translation (GO:0006412)	3.29955871
40	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.28881988
41	cellular component biogenesis (GO:0044085)	3.27128370
42	respiratory chain complex IV assembly (GO:0008535)	3.26693725
43	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.22943831
44	negative regulation of telomere maintenance (GO:0032205)	3.22045749
45	termination of RNA polymerase III transcription (GO:0006386)	3.17104104
46	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.17104104
47	cell proliferation in forebrain (GO:0021846)	3.10790026
48	pyrimidine nucleotide catabolic process (GO:0006244)	3.09800073
49	peptidyl-histidine modification (GO:0018202)	3.07490179
50	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.06081838
51	protein polyglutamylation (GO:0018095)	3.05838005
52	pseudouridine synthesis (GO:0001522)	3.05645200
53	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.04945893
54	base-excision repair, AP site formation (GO:0006285)	2.95907911
55	ATP biosynthetic process (GO:0006754)	2.94963561
56	platelet dense granule organization (GO:0060155)	2.94017498
57	ribonucleoprotein complex biogenesis (GO:0022613)	2.93159271
58	cullin deneddylation (GO:0010388)	2.89633254
59	aldehyde catabolic process (GO:0046185)	2.89399937
60	proteasome assembly (GO:0043248)	2.88165809
61	chromatin remodeling at centromere (GO:0031055)	2.87612468
62	replication fork processing (GO:0031297)	2.86729905
63	piRNA metabolic process (GO:0034587)	2.83320004
64	UTP biosynthetic process (GO:0006228)	2.81951776
65	response to pheromone (GO:0019236)	2.81903297
66	protein complex disassembly (GO:0043241)	2.81369973
67	cytochrome complex assembly (GO:0017004)	2.79754262
68	macromolecular complex disassembly (GO:0032984)	2.79569851
69	protein deneddylation (GO:0000338)	2.79520033
70	rRNA modification (GO:0000154)	2.79058774
71	regulation of cellular amino acid metabolic process (GO:0006521)	2.77702035
72	resolution of meiotic recombination intermediates (GO:0000712)	2.77274010
73	tRNA processing (GO:0008033)	2.76858849
74	mannosylation (GO:0097502)	2.75356455
75	cardiovascular system development (GO:0072358)	2.74967181
76	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.71864995
77	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.71520461
78	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.64712759
79	CENP-A containing nucleosome assembly (GO:0034080)	2.64547282
80	organelle disassembly (GO:1903008)	2.64068574
81	protein targeting to mitochondrion (GO:0006626)	2.63966511
82	protein-cofactor linkage (GO:0018065)	2.63507396
83	UTP metabolic process (GO:0046051)	2.63380970
84	hydrogen ion transmembrane transport (GO:1902600)	2.62470957
85	rRNA processing (GO:0006364)	2.61087154
86	CTP biosynthetic process (GO:0006241)	2.60390235
87	CTP metabolic process (GO:0046036)	2.60390235
88	regulation of helicase activity (GO:0051095)	2.60217824
89	preassembly of GPI anchor in ER membrane (GO:0016254)	2.59763598
90	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.59539713
91	rRNA metabolic process (GO:0016072)	2.59367220
92	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.59175863
93	establishment of protein localization to mitochondrion (GO:0072655)	2.58055380
94	male meiosis I (GO:0007141)	2.56491075
95	ribonucleoprotein complex disassembly (GO:0032988)	2.55988259
96	protein targeting to membrane (GO:0006612)	2.55756571
97	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.55747408
98	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.55747408
99	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.55747408
100	intracellular protein transmembrane import (GO:0044743)	2.55255230

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.41687124
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.19782877
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.87143774
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.44724576
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.21535333
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.19949434
7	VDR_22108803_ChIP-Seq_LS180_Human	3.06725192
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.95355121
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.61248702
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.57291205
11	EZH2_22144423_ChIP-Seq_EOC_Human	2.46788876
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.40127566
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.37172762
14	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.32755984
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.21859322
16	FOXP3_21729870_ChIP-Seq_TREG_Human	2.15489043
17	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.08978875
18	ZNF274_21170338_ChIP-Seq_K562_Hela	2.04126026
19	MYC_18940864_ChIP-ChIP_HL60_Human	2.00070060
20	ELK1_19687146_ChIP-ChIP_HELA_Human	1.93737015
21	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.92526712
22	EWS_26573619_Chip-Seq_HEK293_Human	1.89524231
23	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.87338491
24	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.78727511
25	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.77860863
26	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.77684641
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.73087760
28	FUS_26573619_Chip-Seq_HEK293_Human	1.63734466
29	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.62486424
30	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.62383685
31	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.59740747
32	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.54466783
33	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.53045665
34	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.52729249
35	TTF2_22483619_ChIP-Seq_HELA_Human	1.48560162
36	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.47706819
37	IRF1_19129219_ChIP-ChIP_H3396_Human	1.47584063
38	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.44378422
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.41982608
40	TP53_22573176_ChIP-Seq_HFKS_Human	1.40787306
41	NCOR_22424771_ChIP-Seq_293T_Human	1.33702010
42	GABP_19822575_ChIP-Seq_HepG2_Human	1.33432631
43	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.32358389
44	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.32358389
45	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.30413269
46	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.30345472
47	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.28040525
48	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.25094011
49	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.24748136
50	AR_20517297_ChIP-Seq_VCAP_Human	1.24702073
51	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.24001299
52	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.20920791
53	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.20041635
54	P300_19829295_ChIP-Seq_ESCs_Human	1.19883178
55	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.19358529
56	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.17578869
57	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.11456820
58	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.10982936
59	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.09825819
60	ER_23166858_ChIP-Seq_MCF-7_Human	1.09523627
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.09197451
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.09197451
63	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.09102354
64	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.09007591
65	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.08849514
66	NANOG_20526341_ChIP-Seq_ESCs_Human	1.07850928
67	TAF15_26573619_Chip-Seq_HEK293_Human	1.06190022
68	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.05168166
69	XRN2_22483619_ChIP-Seq_HELA_Human	1.04193823
70	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.03909053
71	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.03576794
72	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.03387721
73	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.01824205
74	RNF2_27304074_Chip-Seq_NSC_Mouse	1.01163236
75	MYC_19829295_ChIP-Seq_ESCs_Human	0.99573970
76	ERA_21632823_ChIP-Seq_H3396_Human	0.98684234
77	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.98372377
78	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.98344725
79	CBP_20019798_ChIP-Seq_JUKART_Human	0.98344725
80	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.98246561
81	HOXB7_26014856_ChIP-Seq_BT474_Human	0.97569021
82	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.96933391
83	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.96252041
84	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.95740576
85	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.95734429
86	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.95723688
87	ERG_20517297_ChIP-Seq_VCAP_Human	0.95085160
88	P53_21459846_ChIP-Seq_SAOS-2_Human	0.94469074
89	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.94195193
90	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.93927686
91	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.93759221
92	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.91909168
93	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.91413021
94	DCP1A_22483619_ChIP-Seq_HELA_Human	0.90404102
95	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.90199515
96	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.89890276
97	TAF2_19829295_ChIP-Seq_ESCs_Human	0.89395521
98	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.89117882
99	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.88285861
100	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.88019135

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.35755413
2	MP0000372_irregular_coat_pigmentation	3.19911826
3	MP0002102_abnormal_ear_morphology	2.91115755
4	MP0009379_abnormal_foot_pigmentation	2.62998599
5	MP0002163_abnormal_gland_morphology	2.57278777
6	MP0006072_abnormal_retinal_apoptosis	2.54594238
7	MP0008877_abnormal_DNA_methylation	2.45111326
8	MP0003787_abnormal_imprinting	2.35643127
9	MP0005671_abnormal_response_to	2.28108878
10	MP0006276_abnormal_autonomic_nervous	2.07843973
11	MP0002837_dystrophic_cardiac_calcinosis	2.07277699
12	MP0003646_muscle_fatigue	2.05118614
13	MP0004142_abnormal_muscle_tone	2.03103453
14	MP0005646_abnormal_pituitary_gland	1.98824976
15	MP0005551_abnormal_eye_electrophysiolog	1.93123766
16	MP0005084_abnormal_gallbladder_morpholo	1.78476808
17	MP0003880_abnormal_central_pattern	1.75644836
18	MP0001968_abnormal_touch/_nociception	1.74490893
19	MP0002876_abnormal_thyroid_physiology	1.71947360
20	MP0008058_abnormal_DNA_repair	1.70381847
21	MP0005645_abnormal_hypothalamus_physiol	1.69526392
22	MP0005075_abnormal_melanosome_morpholog	1.58571574
23	MP0008789_abnormal_olfactory_epithelium	1.55554442
24	MP0005389_reproductive_system_phenotype	1.54453766
25	MP0005379_endocrine/exocrine_gland_phen	1.54227256
26	MP0001905_abnormal_dopamine_level	1.52761441
27	MP0001835_abnormal_antigen_presentation	1.49660632
28	MP0002138_abnormal_hepatobiliary_system	1.48772490
29	MP0002160_abnormal_reproductive_system	1.48566471
30	MP0002272_abnormal_nervous_system	1.46456464
31	MP0001529_abnormal_vocalization	1.46027702
32	MP0001293_anophthalmia	1.45677552
33	MP0004147_increased_porphyrin_level	1.44155399
34	MP0002653_abnormal_ependyma_morphology	1.43447526
35	MP0005253_abnormal_eye_physiology	1.39406129
36	MP0003186_abnormal_redox_activity	1.39316192
37	MP0002638_abnormal_pupillary_reflex	1.38955357
38	MP0003567_abnormal_fetal_cardiomyocyte	1.34147130
39	MP0008875_abnormal_xenobiotic_pharmacok	1.32466791
40	MP0002095_abnormal_skin_pigmentation	1.31953650
41	MP0001986_abnormal_taste_sensitivity	1.28612356
42	MP0001919_abnormal_reproductive_system	1.25403921
43	MP0002234_abnormal_pharynx_morphology	1.23897471
44	MP0000631_abnormal_neuroendocrine_gland	1.21646163
45	MP0003806_abnormal_nucleotide_metabolis	1.21516120
46	MP0008872_abnormal_physiological_respon	1.20333874
47	MP0003136_yellow_coat_color	1.19959808
48	MP0008995_early_reproductive_senescence	1.19584106
49	MP0009745_abnormal_behavioral_response	1.18673225
50	MP0001485_abnormal_pinna_reflex	1.18052361
51	MP0009046_muscle_twitch	1.10120177
52	MP0003123_paternal_imprinting	1.09082975
53	MP0003195_calcinosis	1.08935797
54	MP0002736_abnormal_nociception_after	1.08221668
55	MP0008775_abnormal_heart_ventricle	1.07005211
56	MP0002938_white_spotting	1.03671665
57	MP0006036_abnormal_mitochondrial_physio	1.02850917
58	MP0003011_delayed_dark_adaptation	1.02281839
59	MP0001800_abnormal_humoral_immune	1.00720424
60	MP0005195_abnormal_posterior_eye	1.00565330
61	MP0004885_abnormal_endolymph	1.00516119
62	MP0003786_premature_aging	0.99476067
63	MP0004145_abnormal_muscle_electrophysio	0.99028849
64	MP0000049_abnormal_middle_ear	0.97167362
65	MP0003121_genomic_imprinting	0.95529364
66	MP0002210_abnormal_sex_determination	0.93696313
67	MP0010094_abnormal_chromosome_stability	0.93443655
68	MP0009333_abnormal_splenocyte_physiolog	0.88079465
69	MP0001970_abnormal_pain_threshold	0.86526920
70	MP0000685_abnormal_immune_system	0.85328032
71	MP0005499_abnormal_olfactory_system	0.85237488
72	MP0005394_taste/olfaction_phenotype	0.85237488
73	MP0000427_abnormal_hair_cycle	0.83651043
74	MP0003718_maternal_effect	0.83493986
75	MP0002572_abnormal_emotion/affect_behav	0.83477255
76	MP0004133_heterotaxia	0.83269232
77	MP0002733_abnormal_thermal_nociception	0.83159881
78	MP0003122_maternal_imprinting	0.81349780
79	MP0009785_altered_susceptibility_to	0.80707962
80	MP0002557_abnormal_social/conspecific_i	0.80500771
81	MP0002752_abnormal_somatic_nervous	0.79921403
82	MP0001119_abnormal_female_reproductive	0.78781637
83	MP0001188_hyperpigmentation	0.78675075
84	MP0002148_abnormal_hypersensitivity_rea	0.78418219
85	MP0001963_abnormal_hearing_physiology	0.77721189
86	MP0000230_abnormal_systemic_arterial	0.76517937
87	MP0001486_abnormal_startle_reflex	0.76387294
88	MP0001929_abnormal_gametogenesis	0.73584393
89	MP0000026_abnormal_inner_ear	0.73366362
90	MP0001440_abnormal_grooming_behavior	0.73263601
91	MP0005408_hypopigmentation	0.72813154
92	MP0005360_urolithiasis	0.72565146
93	MP0001324_abnormal_eye_pigmentation	0.71326325
94	MP0002277_abnormal_respiratory_mucosa	0.70216632
95	MP0001984_abnormal_olfaction	0.69669216
96	MP0000653_abnormal_sex_gland	0.68663745
97	MP0002723_abnormal_immune_serum	0.67830802
98	MP0002006_tumorigenesis	0.67373216
99	MP0003878_abnormal_ear_physiology	0.67112303
100	MP0005377_hearing/vestibular/ear_phenot	0.67112303

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.57345073
2	Mitochondrial inheritance (HP:0001427)	4.13758928
3	Acute encephalopathy (HP:0006846)	3.99341568
4	Abnormal mitochondria in muscle tissue (HP:0008316)	3.98895017
5	Increased CSF lactate (HP:0002490)	3.86710837
6	Progressive macrocephaly (HP:0004481)	3.81964493
7	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.63804148
8	Hepatocellular necrosis (HP:0001404)	3.63730553
9	Reticulocytopenia (HP:0001896)	3.54936254
10	Molar tooth sign on MRI (HP:0002419)	3.51806725
11	Abnormality of midbrain morphology (HP:0002418)	3.51806725
12	Abnormality of cells of the erythroid lineage (HP:0012130)	3.29160815
13	Congenital stationary night blindness (HP:0007642)	3.16425769
14	Pancreatic cysts (HP:0001737)	3.12933496
15	Hepatic necrosis (HP:0002605)	3.12811878
16	Cerebral edema (HP:0002181)	3.04945431
17	Abnormal rod and cone electroretinograms (HP:0008323)	3.01591113
18	Renal Fanconi syndrome (HP:0001994)	2.94664287
19	3-Methylglutaconic aciduria (HP:0003535)	2.87831053
20	Optic disc pallor (HP:0000543)	2.87331601
21	Abnormal number of erythroid precursors (HP:0012131)	2.83928062
22	Pancreatic fibrosis (HP:0100732)	2.80929966
23	True hermaphroditism (HP:0010459)	2.76980243
24	Increased hepatocellular lipid droplets (HP:0006565)	2.70874928
25	Nephronophthisis (HP:0000090)	2.67636247
26	Increased serum lactate (HP:0002151)	2.60725836
27	Lipid accumulation in hepatocytes (HP:0006561)	2.58298277
28	Elevated erythrocyte sedimentation rate (HP:0003565)	2.56496165
29	Abolished electroretinogram (ERG) (HP:0000550)	2.55524488
30	Decreased central vision (HP:0007663)	2.53939355
31	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.48532268
32	Lactic acidosis (HP:0003128)	2.48051400
33	Medial flaring of the eyebrow (HP:0010747)	2.48002782
34	Absent thumb (HP:0009777)	2.46073464
35	Macrocytic anemia (HP:0001972)	2.45949925
36	Respiratory failure (HP:0002878)	2.40695773
37	Pendular nystagmus (HP:0012043)	2.34993627
38	IgG deficiency (HP:0004315)	2.33954649
39	Abnormality of the labia minora (HP:0012880)	2.33552073
40	Severe combined immunodeficiency (HP:0004430)	2.33041132
41	Colon cancer (HP:0003003)	2.32113625
42	Hypoproteinemia (HP:0003075)	2.29410058
43	Abnormality of B cell number (HP:0010975)	2.23236749
44	Stenosis of the external auditory canal (HP:0000402)	2.14325481
45	Type II lissencephaly (HP:0007260)	2.13336793
46	Polydipsia (HP:0001959)	2.11260518
47	Abnormal drinking behavior (HP:0030082)	2.11260518
48	Increased IgM level (HP:0003496)	2.10690326
49	Thyroiditis (HP:0100646)	2.07660367
50	B lymphocytopenia (HP:0010976)	2.07042596
51	Sclerocornea (HP:0000647)	2.06026834
52	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.05885708
53	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.05879324
54	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.05879324
55	Absent/shortened dynein arms (HP:0200106)	2.05100431
56	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.05100431
57	Type 2 muscle fiber atrophy (HP:0003554)	2.03612548
58	Agitation (HP:0000713)	2.03485581
59	Methylmalonic acidemia (HP:0002912)	2.03108514
60	Abnormality of the renal medulla (HP:0100957)	2.03077264
61	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.02686809
62	Hypomagnesemia (HP:0002917)	2.01943103
63	Nephrogenic diabetes insipidus (HP:0009806)	2.01438870
64	Lethargy (HP:0001254)	1.99723552
65	Asplenia (HP:0001746)	1.99326626
66	Hyperglycinemia (HP:0002154)	1.99033675
67	Congenital primary aphakia (HP:0007707)	1.98247795
68	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.98092284
69	Gait imbalance (HP:0002141)	1.97143923
70	Pallor (HP:0000980)	1.96578737
71	Panhypogammaglobulinemia (HP:0003139)	1.95696079
72	Abnormality of magnesium homeostasis (HP:0004921)	1.94423722
73	Abnormality of renal resorption (HP:0011038)	1.93229263
74	Increased intramyocellular lipid droplets (HP:0012240)	1.92249220
75	Leukodystrophy (HP:0002415)	1.90931459
76	Polyuria (HP:0000103)	1.87616393
77	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.87324017
78	Exertional dyspnea (HP:0002875)	1.85348970
79	Abnormal respiratory epithelium morphology (HP:0012253)	1.84809747
80	Abnormal respiratory motile cilium morphology (HP:0005938)	1.84809747
81	CNS demyelination (HP:0007305)	1.83657436
82	Adrenal hypoplasia (HP:0000835)	1.82864160
83	Septo-optic dysplasia (HP:0100842)	1.82863794
84	Methylmalonic aciduria (HP:0012120)	1.81868961
85	Aplastic anemia (HP:0001915)	1.81047920
86	Exercise intolerance (HP:0003546)	1.79515094
87	Triphalangeal thumb (HP:0001199)	1.78404941
88	Chronic hepatic failure (HP:0100626)	1.77258451
89	Postaxial foot polydactyly (HP:0001830)	1.76818173
90	Abnormality of alanine metabolism (HP:0010916)	1.74864027
91	Hyperalaninemia (HP:0003348)	1.74864027
92	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.74864027
93	Stomatitis (HP:0010280)	1.74495425
94	Meckel diverticulum (HP:0002245)	1.74454617
95	Abnormality of the ileum (HP:0001549)	1.74291115
96	Anencephaly (HP:0002323)	1.72579415
97	Thyroid-stimulating hormone excess (HP:0002925)	1.70668805
98	Glycosuria (HP:0003076)	1.70459296
99	Abnormality of urine glucose concentration (HP:0011016)	1.70459296
100	Congenital hepatic fibrosis (HP:0002612)	1.69847039

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	3.56973274
2	TXK	3.35743354
3	NUAK1	3.11941626
4	TLK1	2.91574639
5	VRK2	2.60637563
6	ZAK	2.42328248
7	CDK19	2.31688980
8	FRK	2.25389032
9	MAP4K2	2.22251250
10	ADRBK2	2.19464660
11	GRK1	2.18265803
12	BCKDK	2.08854072
13	WNK4	2.08221752
14	TAOK3	1.83513569
15	DYRK2	1.70521106
16	TIE1	1.66790353
17	WNK3	1.63608979
18	VRK1	1.60126917
19	PINK1	1.52187668
20	NME2	1.51124162
21	NEK1	1.39880111
22	MAP2K6	1.39767113
23	EIF2AK3	1.39738105
24	BMPR1B	1.32043396
25	PLK4	1.24113218
26	PIK3CA	1.16971874
27	KDR	1.15462705
28	MKNK2	1.11372832
29	PASK	1.11052655
30	KIT	1.07081310
31	TEC	1.06297495
32	PDK2	1.05383869
33	IKBKE	1.05350046
34	TRIM28	1.04234809
35	TAF1	1.03698875
36	CSNK1G3	1.03384935
37	MST4	1.03208274
38	PLK3	1.03191191
39	CDC7	1.02477983
40	OXSR1	1.01506396
41	STK39	0.94960977
42	FLT3	0.94244240
43	ITK	0.88224642
44	SCYL2	0.83346882
45	CSNK1G1	0.82912850
46	CSNK1G2	0.81771436
47	TAOK2	0.80878415
48	INSRR	0.80878134
49	MAP3K12	0.80594847
50	FES	0.79941073
51	MKNK1	0.78538740
52	MARK3	0.77859414
53	PLK2	0.76555554
54	BUB1	0.75266411
55	BCR	0.72393677
56	IKBKB	0.71103753
57	TNIK	0.69941690
58	PRKCQ	0.69607925
59	SYK	0.67557386
60	TESK2	0.67481623
61	PRKCG	0.66885071
62	CSNK1A1L	0.65169744
63	PLK1	0.64060241
64	NME1	0.63726987
65	ATR	0.61880109
66	DAPK1	0.59027761
67	EIF2AK1	0.57108511
68	NEK2	0.56441359
69	BTK	0.56157502
70	AURKB	0.56142020
71	PRKACA	0.55621861
72	WEE1	0.52764698
73	ABL2	0.51579365
74	CASK	0.51195300
75	PRKCH	0.51035915
76	CSNK2A1	0.50368789
77	PAK3	0.50355221
78	RPS6KA5	0.49972940
79	PHKG2	0.49147145
80	PHKG1	0.49147145
81	CSNK2A2	0.48749371
82	MAPK13	0.48209105
83	DAPK3	0.47624782
84	CSF1R	0.47163172
85	STK11	0.46237187
86	NLK	0.46019766
87	MINK1	0.45186593
88	MAP4K1	0.44428022
89	MAP3K11	0.44120680
90	PIM1	0.44057243
91	MAP2K7	0.44005363
92	MAPKAPK3	0.42494296
93	LYN	0.42388901
94	MAP3K5	0.41305043
95	EIF2AK2	0.38823037
96	PRKCA	0.38126626
97	PRKCI	0.38045681
98	PRKCE	0.37862736
99	OBSCN	0.37375841
100	CSNK1A1	0.36853096

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.51789037
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.79405732
3	Proteasome_Homo sapiens_hsa03050	3.51621143
4	Parkinsons disease_Homo sapiens_hsa05012	3.29400663
5	RNA polymerase_Homo sapiens_hsa03020	2.65450630
6	Homologous recombination_Homo sapiens_hsa03440	2.46629388
7	Protein export_Homo sapiens_hsa03060	2.43507296
8	Alzheimers disease_Homo sapiens_hsa05010	2.12361619
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.10449535
10	Huntingtons disease_Homo sapiens_hsa05016	2.08653801
11	One carbon pool by folate_Homo sapiens_hsa00670	2.08298062
12	Asthma_Homo sapiens_hsa05310	2.07429587
13	Primary immunodeficiency_Homo sapiens_hsa05340	1.89673165
14	Fanconi anemia pathway_Homo sapiens_hsa03460	1.89420627
15	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.83692458
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.80452207
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.79628748
18	Phototransduction_Homo sapiens_hsa04744	1.79288647
19	Mismatch repair_Homo sapiens_hsa03430	1.70460845
20	Cardiac muscle contraction_Homo sapiens_hsa04260	1.69580116
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.61823735
22	Propanoate metabolism_Homo sapiens_hsa00640	1.59981301
23	Allograft rejection_Homo sapiens_hsa05330	1.59413913
24	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.56630661
25	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.55857033
26	Pyrimidine metabolism_Homo sapiens_hsa00240	1.49899254
27	DNA replication_Homo sapiens_hsa03030	1.46958206
28	Basal transcription factors_Homo sapiens_hsa03022	1.42078938
29	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.40091487
30	RNA degradation_Homo sapiens_hsa03018	1.39009311
31	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.37920843
32	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.35710388
33	Type I diabetes mellitus_Homo sapiens_hsa04940	1.31252776
34	Graft-versus-host disease_Homo sapiens_hsa05332	1.27661867
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.20538611
36	Non-homologous end-joining_Homo sapiens_hsa03450	1.17740564
37	Nucleotide excision repair_Homo sapiens_hsa03420	1.07976079
38	Purine metabolism_Homo sapiens_hsa00230	1.06064282
39	Base excision repair_Homo sapiens_hsa03410	1.04932033
40	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.00760156
41	Fatty acid elongation_Homo sapiens_hsa00062	1.00265009
42	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.99952465
43	Butanoate metabolism_Homo sapiens_hsa00650	0.98422294
44	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.94530760
45	Sulfur metabolism_Homo sapiens_hsa00920	0.93700690
46	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.92882822
47	Peroxisome_Homo sapiens_hsa04146	0.92779228
48	RNA transport_Homo sapiens_hsa03013	0.92135515
49	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.90551720
50	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.87758575
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.84574053
52	Tryptophan metabolism_Homo sapiens_hsa00380	0.83904004
53	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.83217209
54	Nitrogen metabolism_Homo sapiens_hsa00910	0.82973432
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.80664372
56	Olfactory transduction_Homo sapiens_hsa04740	0.77502083
57	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.76791474
58	Rheumatoid arthritis_Homo sapiens_hsa05323	0.75231767
59	Metabolic pathways_Homo sapiens_hsa01100	0.74670254
60	Regulation of autophagy_Homo sapiens_hsa04140	0.74417122
61	Spliceosome_Homo sapiens_hsa03040	0.73208318
62	Selenocompound metabolism_Homo sapiens_hsa00450	0.71732903
63	Caffeine metabolism_Homo sapiens_hsa00232	0.70197714
64	Ether lipid metabolism_Homo sapiens_hsa00565	0.69739998
65	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.68265532
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.67131327
67	Antigen processing and presentation_Homo sapiens_hsa04612	0.66394319
68	Glutathione metabolism_Homo sapiens_hsa00480	0.66393016
69	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.63356071
70	beta-Alanine metabolism_Homo sapiens_hsa00410	0.59566451
71	Fat digestion and absorption_Homo sapiens_hsa04975	0.57869768
72	Collecting duct acid secretion_Homo sapiens_hsa04966	0.57139629
73	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.57091924
74	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.54394474
75	Retinol metabolism_Homo sapiens_hsa00830	0.54067682
76	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.52422364
77	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.50228524
78	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.50017658
79	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.49404389
80	Nicotine addiction_Homo sapiens_hsa05033	0.49040822
81	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.45872200
82	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.45333787
83	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.44687302
84	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.43815486
85	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.43453527
86	p53 signaling pathway_Homo sapiens_hsa04115	0.38448716
87	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.37476632
88	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.36290983
89	Folate biosynthesis_Homo sapiens_hsa00790	0.35897319
90	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.35298559
91	Fatty acid metabolism_Homo sapiens_hsa01212	0.33469062
92	Fatty acid degradation_Homo sapiens_hsa00071	0.32264295
93	Sulfur relay system_Homo sapiens_hsa04122	0.31502418
94	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.31471883
95	Morphine addiction_Homo sapiens_hsa05032	0.30144750
96	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.29627791
97	Pyruvate metabolism_Homo sapiens_hsa00620	0.29247003
98	Taste transduction_Homo sapiens_hsa04742	0.28953985
99	Salivary secretion_Homo sapiens_hsa04970	0.24244936
100	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.19399085

RPL7AP11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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