ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	7.24395207
2	ribosomal small subunit biogenesis (GO:0042274)	5.81309442
3	protein-cofactor linkage (GO:0018065)	5.48196879
4	water-soluble vitamin biosynthetic process (GO:0042364)	5.31691560
5	viral transcription (GO:0019083)	4.96740926
6	ncRNA 3-end processing (GO:0043628)	4.95284400
7	ATP synthesis coupled proton transport (GO:0015986)	4.79378261
8	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.79378261
9	translational termination (GO:0006415)	4.76862528
10	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.51589011
11	activated T cell proliferation (GO:0050798)	4.50715418
12	chaperone-mediated protein transport (GO:0072321)	4.46730855
13	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.35958498
14	DNA deamination (GO:0045006)	4.29176899
15	protein complex biogenesis (GO:0070271)	4.12077891
16	translational elongation (GO:0006414)	4.11125618
17	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.10257624
18	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.08176257
19	NADH dehydrogenase complex assembly (GO:0010257)	4.08176257
20	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.08176257
21	cotranslational protein targeting to membrane (GO:0006613)	4.07690246
22	transcription from RNA polymerase I promoter (GO:0006360)	4.03424989
23	ubiquinone biosynthetic process (GO:0006744)	4.03220987
24	protein targeting to ER (GO:0045047)	4.01393889
25	protein neddylation (GO:0045116)	3.98404438
26	mitochondrial respiratory chain complex assembly (GO:0033108)	3.90074793
27	GTP biosynthetic process (GO:0006183)	3.89782668
28	rRNA modification (GO:0000154)	3.89164317
29	protein localization to endoplasmic reticulum (GO:0070972)	3.88068257
30	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.81329013
31	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.80850662
32	ribosomal large subunit biogenesis (GO:0042273)	3.74318834
33	ubiquinone metabolic process (GO:0006743)	3.72236297
34	termination of RNA polymerase III transcription (GO:0006386)	3.69606135
35	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.69606135
36	rRNA methylation (GO:0031167)	3.68788431
37	respiratory electron transport chain (GO:0022904)	3.61300345
38	maturation of SSU-rRNA (GO:0030490)	3.60267860
39	electron transport chain (GO:0022900)	3.59031807
40	cellular protein complex disassembly (GO:0043624)	3.48541086
41	regulation of protein glycosylation (GO:0060049)	3.44247736
42	behavioral response to nicotine (GO:0035095)	3.43251514
43	viral life cycle (GO:0019058)	3.40463871
44	UTP metabolic process (GO:0046051)	3.39219447
45	UTP biosynthetic process (GO:0006228)	3.33631134
46	xenobiotic catabolic process (GO:0042178)	3.33209175
47	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.32809896
48	translational initiation (GO:0006413)	3.30451014
49	quinone biosynthetic process (GO:1901663)	3.27082133
50	cellular component biogenesis (GO:0044085)	3.26301954
51	positive regulation of glycoprotein biosynthetic process (GO:0010560)	3.23480486
52	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.13299768
53	translation (GO:0006412)	3.09439700
54	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.07066067
55	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.06702774
56	ribonucleoprotein complex biogenesis (GO:0022613)	3.06235637
57	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.01574505
58	protein polyglutamylation (GO:0018095)	3.00718136
59	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.94031228
60	termination of RNA polymerase I transcription (GO:0006363)	2.93391245
61	glycerophospholipid catabolic process (GO:0046475)	2.92433071
62	response to nitrosative stress (GO:0051409)	2.90868813
63	platelet dense granule organization (GO:0060155)	2.89759437
64	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.89680248
65	indolalkylamine metabolic process (GO:0006586)	2.87738151
66	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.87439248
67	piRNA metabolic process (GO:0034587)	2.82357245
68	ATP biosynthetic process (GO:0006754)	2.80467018
69	protein deneddylation (GO:0000338)	2.79911458
70	hydrogen ion transmembrane transport (GO:1902600)	2.73973178
71	protein complex disassembly (GO:0043241)	2.73240152
72	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.72271021
73	rRNA processing (GO:0006364)	2.71314038
74	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.70119633
75	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.70119633
76	fucose catabolic process (GO:0019317)	2.69488472
77	L-fucose metabolic process (GO:0042354)	2.69488472
78	L-fucose catabolic process (GO:0042355)	2.69488472
79	pseudouridine synthesis (GO:0001522)	2.68107603
80	positive regulation of natural killer cell differentiation (GO:0032825)	2.67183408
81	CTP biosynthetic process (GO:0006241)	2.66373375
82	CTP metabolic process (GO:0046036)	2.66373375
83	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.65105478
84	rRNA metabolic process (GO:0016072)	2.62610568
85	cellular anion homeostasis (GO:0030002)	2.59085390
86	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.58473484
87	intracellular protein transmembrane import (GO:0044743)	2.56091407
88	proton transport (GO:0015992)	2.55900972
89	macromolecular complex disassembly (GO:0032984)	2.55625475
90	negative regulation of T cell differentiation in thymus (GO:0033085)	2.53266752
91	cytidine deamination (GO:0009972)	2.52781036
92	cytidine metabolic process (GO:0046087)	2.52781036
93	cytidine catabolic process (GO:0006216)	2.52781036
94	hydrogen transport (GO:0006818)	2.51459780
95	isoprenoid biosynthetic process (GO:0008299)	2.50882570
96	diacylglycerol metabolic process (GO:0046339)	2.50804606
97	protein targeting to membrane (GO:0006612)	2.50265103
98	vitamin biosynthetic process (GO:0009110)	2.46558585
99	tRNA processing (GO:0008033)	2.43616014
100	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.42290818

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	8.57282671
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.67493052
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.04620102
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.38449672
5	VDR_22108803_ChIP-Seq_LS180_Human	3.36689609
6	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.36257012
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.32108289
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.29033759
9	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.65994855
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.57324425
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.53707411
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.35659886
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.21507444
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.17930779
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.03939320
16	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.03079798
17	IRF1_19129219_ChIP-ChIP_H3396_Human	1.92523290
18	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.86844871
19	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.84578885
20	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.74391705
21	VDR_23849224_ChIP-Seq_CD4+_Human	1.72797631
22	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.53513021
23	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.49242195
24	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.44501714
25	TP53_22573176_ChIP-Seq_HFKS_Human	1.40585781
26	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.40487092
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.38895836
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.38672046
29	BCAT_22108803_ChIP-Seq_LS180_Human	1.30952373
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.29093172
31	TTF2_22483619_ChIP-Seq_HELA_Human	1.28969188
32	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.28707985
33	TAF2_19829295_ChIP-Seq_ESCs_Human	1.25845442
34	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.21226777
35	EWS_26573619_Chip-Seq_HEK293_Human	1.19274902
36	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16642736
37	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.16127824
38	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.16018363
39	NANOG_19829295_ChIP-Seq_ESCs_Human	1.15496792
40	SOX2_19829295_ChIP-Seq_ESCs_Human	1.15496792
41	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.14172080
42	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.13895584
43	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.07140158
44	FOXP3_21729870_ChIP-Seq_TREG_Human	1.06121010
45	P53_21459846_ChIP-Seq_SAOS-2_Human	1.05949850
46	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.05408142
47	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.04583524
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.04253351
49	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.04044902
50	IGF1R_20145208_ChIP-Seq_DFB_Human	1.03749954
51	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.03425572
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.03255783
53	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.03255783
54	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.01885118
55	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.01583897
56	FUS_26573619_Chip-Seq_HEK293_Human	1.01045163
57	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.00097416
58	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.99142919
59	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.98170006
60	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.98131557
61	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97694232
62	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.97410615
63	REST_21632747_ChIP-Seq_MESCs_Mouse	0.95330053
64	ERA_21632823_ChIP-Seq_H3396_Human	0.94592073
65	P300_19829295_ChIP-Seq_ESCs_Human	0.93427532
66	SOX2_21211035_ChIP-Seq_LN229_Human	0.93350478
67	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.93289193
68	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.93165345
69	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.92917942
70	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.92399033
71	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.92071678
72	MYC_19829295_ChIP-Seq_ESCs_Human	0.91790550
73	NANOG_20526341_ChIP-Seq_ESCs_Human	0.90632071
74	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.89961613
75	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.89865897
76	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.89830200
77	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.89612331
78	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.88125741
79	AR_20517297_ChIP-Seq_VCAP_Human	0.87396042
80	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.87387543
81	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.86935629
82	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.86722135
83	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.85973446
84	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.85380999
85	GABP_19822575_ChIP-Seq_HepG2_Human	0.85269395
86	GATA3_26560356_Chip-Seq_TH2_Human	0.84353515
87	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.84329180
88	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.83055755
89	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.80945899
90	CBP_20019798_ChIP-Seq_JUKART_Human	0.80446116
91	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.80446116
92	NCOR_22424771_ChIP-Seq_293T_Human	0.79476948
93	ERG_20517297_ChIP-Seq_VCAP_Human	0.79331893
94	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.78792308
95	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.78201422
96	ELK1_19687146_ChIP-ChIP_HELA_Human	0.77922919
97	RNF2_27304074_Chip-Seq_NSC_Mouse	0.77671998
98	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.77617093
99	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.77250787
100	P300_27268052_Chip-Seq_Bcells_Human	0.75123660

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.89839553
2	MP0002138_abnormal_hepatobiliary_system	3.63412692
3	MP0009379_abnormal_foot_pigmentation	3.45768837
4	MP0005408_hypopigmentation	3.26984696
5	MP0003646_muscle_fatigue	3.10141499
6	MP0005645_abnormal_hypothalamus_physiol	3.03815818
7	MP0002102_abnormal_ear_morphology	3.01433223
8	MP0001529_abnormal_vocalization	2.67477091
9	MP0008877_abnormal_DNA_methylation	2.47970006
10	MP0006072_abnormal_retinal_apoptosis	2.30959581
11	MP0004142_abnormal_muscle_tone	2.24757023
12	MP0008875_abnormal_xenobiotic_pharmacok	2.20753022
13	MP0001905_abnormal_dopamine_level	2.17875979
14	MP0004742_abnormal_vestibular_system	2.16286187
15	MP0001873_stomach_inflammation	2.09768520
16	MP0005671_abnormal_response_to	2.08668517
17	MP0004885_abnormal_endolymph	1.96621904
18	MP0001835_abnormal_antigen_presentation	1.95496966
19	MP0002837_dystrophic_cardiac_calcinosis	1.90039488
20	MP0002876_abnormal_thyroid_physiology	1.81532972
21	MP0003011_delayed_dark_adaptation	1.80613300
22	MP0003122_maternal_imprinting	1.77927886
23	MP0008872_abnormal_physiological_respon	1.76748679
24	MP0002277_abnormal_respiratory_mucosa	1.65136244
25	MP0006035_abnormal_mitochondrial_morpho	1.60828463
26	MP0005253_abnormal_eye_physiology	1.59983377
27	MP0006036_abnormal_mitochondrial_physio	1.58700995
28	MP0001502_abnormal_circadian_rhythm	1.58685407
29	MP0003186_abnormal_redox_activity	1.51593482
30	MP0003787_abnormal_imprinting	1.51001139
31	MP0003195_calcinosis	1.48949214
32	MP0000049_abnormal_middle_ear	1.47190200
33	MP0005377_hearing/vestibular/ear_phenot	1.45639971
34	MP0003878_abnormal_ear_physiology	1.45639971
35	MP0003121_genomic_imprinting	1.43779302
36	MP0004145_abnormal_muscle_electrophysio	1.40289527
37	MP0001968_abnormal_touch/_nociception	1.40142087
38	MP0002933_joint_inflammation	1.40017785
39	MP0005084_abnormal_gallbladder_morpholo	1.36004421
40	MP0000372_irregular_coat_pigmentation	1.34015492
41	MP0005551_abnormal_eye_electrophysiolog	1.31921062
42	MP0002736_abnormal_nociception_after	1.31492956
43	MP0009046_muscle_twitch	1.24277326
44	MP0009745_abnormal_behavioral_response	1.23658314
45	MP0002938_white_spotting	1.15074299
46	MP0002272_abnormal_nervous_system	1.14445535
47	MP0003718_maternal_effect	1.12496642
48	MP0001986_abnormal_taste_sensitivity	1.11666038
49	MP0004133_heterotaxia	1.06481002
50	MP0005195_abnormal_posterior_eye	1.04055544
51	MP0000778_abnormal_nervous_system	1.03445928
52	MP0008789_abnormal_olfactory_epithelium	1.02618641
53	MP0005379_endocrine/exocrine_gland_phen	1.02061672
54	MP0005075_abnormal_melanosome_morpholog	0.99616783
55	MP0006276_abnormal_autonomic_nervous	0.98715555
56	MP0001293_anophthalmia	0.98411516
57	MP0001800_abnormal_humoral_immune	0.98083078
58	MP0003567_abnormal_fetal_cardiomyocyte	0.97789048
59	MP0005636_abnormal_mineral_homeostasis	0.96279624
60	MP0008775_abnormal_heart_ventricle	0.96017285
61	MP0009785_altered_susceptibility_to	0.93237283
62	MP0002139_abnormal_hepatobiliary_system	0.92859845
63	MP0001790_abnormal_immune_system	0.91466676
64	MP0005387_immune_system_phenotype	0.91466676
65	MP0002733_abnormal_thermal_nociception	0.89521628
66	MP0000631_abnormal_neuroendocrine_gland	0.88024924
67	MP0003937_abnormal_limbs/digits/tail_de	0.87688710
68	MP0005389_reproductive_system_phenotype	0.87550328
69	MP0002572_abnormal_emotion/affect_behav	0.86278461
70	MP0005670_abnormal_white_adipose	0.85378497
71	MP0005197_abnormal_uvea_morphology	0.82995099
72	MP0002160_abnormal_reproductive_system	0.81778302
73	MP0002163_abnormal_gland_morphology	0.80867342
74	MP0001486_abnormal_startle_reflex	0.80763011
75	MP0002557_abnormal_social/conspecific_i	0.80503726
76	MP0001970_abnormal_pain_threshold	0.79690390
77	MP0000026_abnormal_inner_ear	0.77960404
78	MP0004924_abnormal_behavior	0.77404640
79	MP0005386_behavior/neurological_phenoty	0.77404640
80	MP0009333_abnormal_splenocyte_physiolog	0.77146091
81	MP0002752_abnormal_somatic_nervous	0.76641742
82	MP0002095_abnormal_skin_pigmentation	0.76192250
83	MP0003880_abnormal_central_pattern	0.75164438
84	MP0002735_abnormal_chemical_nociception	0.74462337
85	MP0002067_abnormal_sensory_capabilities	0.74292343
86	MP0002210_abnormal_sex_determination	0.73556289
87	MP0001919_abnormal_reproductive_system	0.73260237
88	MP0005000_abnormal_immune_tolerance	0.73221305
89	MP0000015_abnormal_ear_pigmentation	0.71771412
90	MP0001663_abnormal_digestive_system	0.71196626
91	MP0005365_abnormal_bile_salt	0.69839304
92	MP0002148_abnormal_hypersensitivity_rea	0.69586052
93	MP0009764_decreased_sensitivity_to	0.68893349
94	MP0002064_seizures	0.68675323
95	MP0003693_abnormal_embryo_hatching	0.68551768
96	MP0001984_abnormal_olfaction	0.65665768
97	MP0010386_abnormal_urinary_bladder	0.65055938
98	MP0001270_distended_abdomen	0.64802006
99	MP0005381_digestive/alimentary_phenotyp	0.64635638
100	MP0001348_abnormal_lacrimal_gland	0.61814821

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.54143483
2	Increased IgM level (HP:0003496)	4.03701878
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.01351536
4	Acute encephalopathy (HP:0006846)	3.86957531
5	Mitochondrial inheritance (HP:0001427)	3.79655119
6	Progressive macrocephaly (HP:0004481)	3.79233476
7	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.63862057
8	Recurrent gram-negative bacterial infections (HP:0005420)	3.62205104
9	Hepatocellular necrosis (HP:0001404)	3.53155222
10	Increased CSF lactate (HP:0002490)	3.44421769
11	3-Methylglutaconic aciduria (HP:0003535)	3.24379318
12	Pancreatic fibrosis (HP:0100732)	3.08300095
13	Abnormality of cells of the erythroid lineage (HP:0012130)	3.01784676
14	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.95108525
15	Optic disc pallor (HP:0000543)	2.91836893
16	Abnormal respiratory motile cilium physiology (HP:0012261)	2.91742650
17	Chronic bronchitis (HP:0004469)	2.91255570
18	Hepatic necrosis (HP:0002605)	2.90424970
19	Congenital stationary night blindness (HP:0007642)	2.86849254
20	Increased hepatocellular lipid droplets (HP:0006565)	2.86506708
21	Cerebral edema (HP:0002181)	2.86048275
22	Cerebellar dysplasia (HP:0007033)	2.84531723
23	Abolished electroretinogram (ERG) (HP:0000550)	2.84017339
24	Lipid accumulation in hepatocytes (HP:0006561)	2.82010759
25	Increased serum lactate (HP:0002151)	2.77897122
26	Pancreatic cysts (HP:0001737)	2.74512437
27	Chorioretinal atrophy (HP:0000533)	2.68419209
28	Macrocytic anemia (HP:0001972)	2.67845071
29	Stomatitis (HP:0010280)	2.67220199
30	Abnormal number of erythroid precursors (HP:0012131)	2.64261781
31	Stenosis of the external auditory canal (HP:0000402)	2.62426733
32	Hyperglycinemia (HP:0002154)	2.58338080
33	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.57618846
34	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.57618846
35	Periodontitis (HP:0000704)	2.50398205
36	Methylmalonic acidemia (HP:0002912)	2.47962302
37	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.46664475
38	Nephronophthisis (HP:0000090)	2.43920971
39	11 pairs of ribs (HP:0000878)	2.43057021
40	Reticulocytopenia (HP:0001896)	2.42867058
41	Abnormality of midbrain morphology (HP:0002418)	2.40474123
42	Molar tooth sign on MRI (HP:0002419)	2.40474123
43	Leukocytosis (HP:0001974)	2.38612035
44	Exertional dyspnea (HP:0002875)	2.32441868
45	Renal Fanconi syndrome (HP:0001994)	2.32253456
46	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.30448147
47	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.29843731
48	Limb dystonia (HP:0002451)	2.29526413
49	Sparse scalp hair (HP:0002209)	2.26259471
50	Metaphyseal dysplasia (HP:0100255)	2.24539566
51	Lactic acidosis (HP:0003128)	2.18509012
52	Abnormal ciliary motility (HP:0012262)	2.16714095
53	Polydipsia (HP:0001959)	2.11613910
54	Abnormal drinking behavior (HP:0030082)	2.11613910
55	Abnormality of T cell physiology (HP:0011840)	2.08593714
56	Methylmalonic aciduria (HP:0012120)	2.07866176
57	Abnormality of the renal medulla (HP:0100957)	2.06257151
58	Lethargy (HP:0001254)	2.06248607
59	Attenuation of retinal blood vessels (HP:0007843)	2.05136100
60	Pendular nystagmus (HP:0012043)	2.04785115
61	Glycosuria (HP:0003076)	2.04378953
62	Abnormality of urine glucose concentration (HP:0011016)	2.04378953
63	Septo-optic dysplasia (HP:0100842)	2.02560959
64	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.02226180
65	Asplenia (HP:0001746)	2.01219038
66	Hypoplasia of the uterus (HP:0000013)	1.99638383
67	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.99512912
68	Abnormal rod and cone electroretinograms (HP:0008323)	1.98517037
69	Myokymia (HP:0002411)	1.98059336
70	Aplasia/hypoplasia of the uterus (HP:0008684)	1.97718327
71	Short tibia (HP:0005736)	1.95296620
72	Autoimmune thrombocytopenia (HP:0001973)	1.93692907
73	Colon cancer (HP:0003003)	1.90992230
74	True hermaphroditism (HP:0010459)	1.90948460
75	Leukodystrophy (HP:0002415)	1.90765539
76	Maternal diabetes (HP:0009800)	1.88064954
77	Pallor (HP:0000980)	1.87333907
78	Respiratory failure (HP:0002878)	1.86308487
79	Abnormality of eosinophils (HP:0001879)	1.84962686
80	Pachygyria (HP:0001302)	1.84178257
81	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.84042109
82	Increased intramyocellular lipid droplets (HP:0012240)	1.82502989
83	Nasal speech (HP:0001611)	1.82212628
84	Anencephaly (HP:0002323)	1.82035872
85	Hypothermia (HP:0002045)	1.80907559
86	Polyuria (HP:0000103)	1.80496764
87	Polyphagia (HP:0002591)	1.79951000
88	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.77010481
89	Rhinitis (HP:0012384)	1.76694113
90	Type II lissencephaly (HP:0007260)	1.75835101
91	Gingivitis (HP:0000230)	1.69181850
92	Hypergammaglobulinemia (HP:0010702)	1.69093697
93	Exercise intolerance (HP:0003546)	1.66613410
94	Panhypogammaglobulinemia (HP:0003139)	1.65149196
95	Optic nerve hypoplasia (HP:0000609)	1.64363415
96	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.63742616
97	Retrobulbar optic neuritis (HP:0100654)	1.63450982
98	Optic neuritis (HP:0100653)	1.63450982
99	Abnormality of glycine metabolism (HP:0010895)	1.62534040
100	Abnormality of serine family amino acid metabolism (HP:0010894)	1.62534040

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PBK	3.43291936
2	TXK	3.13899109
3	TLK1	2.87126145
4	WNK4	2.86067084
5	TIE1	2.72886345
6	PRKCH	2.64116715
7	ADRBK2	2.40365964
8	CDK19	2.40081814
9	STK16	2.39981730
10	NTRK3	2.35419443
11	PINK1	2.26551561
12	NUAK1	2.20383483
13	GRK1	2.20246858
14	MAP2K6	2.09938014
15	DYRK2	1.99808833
16	ZAK	1.97767503
17	BCKDK	1.95651969
18	OXSR1	1.71749087
19	WNK3	1.55775171
20	TYRO3	1.48173039
21	CASK	1.38433339
22	EPHB1	1.34598336
23	EPHA3	1.33607028
24	VRK2	1.33323019
25	TAOK3	1.32849920
26	FES	1.27380157
27	STK39	1.25372194
28	TSSK6	1.23996309
29	RPS6KA4	1.23208289
30	DAPK1	1.21701411
31	MST4	1.14732324
32	DYRK3	1.14371013
33	NTRK2	1.09346362
34	KSR1	1.08310990
35	NME2	1.07361629
36	TRIM28	1.03257815
37	MAP4K2	1.01397566
38	RPS6KA5	0.96630624
39	MAP3K8	0.94757660
40	CAMKK2	0.94111709
41	FRK	0.93710677
42	KSR2	0.92306936
43	MAP3K2	0.88850919
44	ADRBK1	0.88421105
45	VRK1	0.86492401
46	CAMK2D	0.84164016
47	RPS6KA6	0.83906691
48	BUB1	0.83330730
49	CDK3	0.81660560
50	RAF1	0.80703241
51	GRK7	0.78031294
52	EPHB2	0.76391880
53	TAF1	0.75605274
54	RPS6KL1	0.71326924
55	RPS6KC1	0.71326924
56	PRKCQ	0.66721719
57	PAK3	0.65576974
58	EPHA4	0.65326180
59	MAP3K12	0.63631169
60	EIF2AK1	0.62156842
61	MAP4K1	0.62037738
62	BMPR1B	0.61266401
63	MAP3K11	0.60213953
64	SGK2	0.59975954
65	CAMK2A	0.59065535
66	PRKCG	0.57893235
67	SGK223	0.57697317
68	SGK494	0.57697317
69	NLK	0.57541213
70	IKBKB	0.56219068
71	KIT	0.55870591
72	CSNK1G2	0.54940721
73	INSRR	0.54299109
74	CAMK2B	0.52865005
75	WNK1	0.52014890
76	CSNK1G1	0.51344730
77	MINK1	0.50530608
78	PRKACA	0.50467957
79	ALK	0.49806071
80	PLK4	0.49392137
81	PRKCE	0.49338935
82	NME1	0.48843236
83	CSNK1A1	0.47972852
84	LCK	0.47861267
85	RPS6KA2	0.47444554
86	CAMK2G	0.46089776
87	PIK3CA	0.45339095
88	PRKCD	0.41964677
89	PASK	0.40077856
90	CSNK1E	0.39990164
91	CSNK1G3	0.39704268
92	CDK14	0.38928398
93	SRPK1	0.38774302
94	JAK2	0.38593063
95	CSNK2A2	0.35567896
96	ATR	0.35272673
97	MAPKAPK5	0.34433229
98	PRKCA	0.33651382
99	BRAF	0.31543339
100	CLK1	0.30220543

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	RNA polymerase_Homo sapiens_hsa03020	4.52968433
2	Ribosome_Homo sapiens_hsa03010	4.22721359
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.40075992
4	Parkinsons disease_Homo sapiens_hsa05012	3.23927759
5	Allograft rejection_Homo sapiens_hsa05330	2.58035599
6	Proteasome_Homo sapiens_hsa03050	2.44072726
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.39898136
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.28325146
9	Asthma_Homo sapiens_hsa05310	2.27095839
10	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.25403895
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.09641980
12	Huntingtons disease_Homo sapiens_hsa05016	2.01849883
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.90841748
14	Type I diabetes mellitus_Homo sapiens_hsa04940	1.88068909
15	Graft-versus-host disease_Homo sapiens_hsa05332	1.87590358
16	Sulfur relay system_Homo sapiens_hsa04122	1.81148848
17	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.80412083
18	Alzheimers disease_Homo sapiens_hsa05010	1.80021275
19	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.77403949
20	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.72457790
21	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.65523415
22	Fatty acid elongation_Homo sapiens_hsa00062	1.60255677
23	Cardiac muscle contraction_Homo sapiens_hsa04260	1.55271814
24	Pyrimidine metabolism_Homo sapiens_hsa00240	1.48759955
25	Primary immunodeficiency_Homo sapiens_hsa05340	1.48478654
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.46105203
27	One carbon pool by folate_Homo sapiens_hsa00670	1.40047578
28	Rheumatoid arthritis_Homo sapiens_hsa05323	1.36377640
29	Viral myocarditis_Homo sapiens_hsa05416	1.36083479
30	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.23573071
31	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.20110633
32	Protein export_Homo sapiens_hsa03060	1.19682778
33	Phototransduction_Homo sapiens_hsa04744	1.18117763
34	Ether lipid metabolism_Homo sapiens_hsa00565	1.13706575
35	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.12957557
36	Fat digestion and absorption_Homo sapiens_hsa04975	1.10862282
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.06557766
38	Chemical carcinogenesis_Homo sapiens_hsa05204	1.05691117
39	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.04114239
40	Purine metabolism_Homo sapiens_hsa00230	1.03999975
41	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.02501807
42	Basal transcription factors_Homo sapiens_hsa03022	1.01216978
43	RNA degradation_Homo sapiens_hsa03018	0.99416275
44	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.99035254
45	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.96774562
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.94878533
47	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.94505763
48	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.93551946
49	Nitrogen metabolism_Homo sapiens_hsa00910	0.90875614
50	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.87960761
51	Peroxisome_Homo sapiens_hsa04146	0.84159594
52	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.83487913
53	Caffeine metabolism_Homo sapiens_hsa00232	0.82857576
54	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.81816675
55	Retinol metabolism_Homo sapiens_hsa00830	0.78001784
56	Spliceosome_Homo sapiens_hsa03040	0.76903010
57	Steroid biosynthesis_Homo sapiens_hsa00100	0.76356614
58	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.74915362
59	Fanconi anemia pathway_Homo sapiens_hsa03460	0.73944480
60	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.73571776
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.70934377
62	Malaria_Homo sapiens_hsa05144	0.69499272
63	Butanoate metabolism_Homo sapiens_hsa00650	0.69210404
64	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.68366516
65	Propanoate metabolism_Homo sapiens_hsa00640	0.68047535
66	Leishmaniasis_Homo sapiens_hsa05140	0.65446174
67	Metabolic pathways_Homo sapiens_hsa01100	0.64802253
68	Nicotine addiction_Homo sapiens_hsa05033	0.64774264
69	Folate biosynthesis_Homo sapiens_hsa00790	0.64648753
70	RNA transport_Homo sapiens_hsa03013	0.62151210
71	Antigen processing and presentation_Homo sapiens_hsa04612	0.60999622
72	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.59757970
73	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.59676968
74	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.57976512
75	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.52838109
76	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.51802919
77	Serotonergic synapse_Homo sapiens_hsa04726	0.50324199
78	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.50056404
79	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.49393725
80	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.47308296
81	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.46250881
82	Homologous recombination_Homo sapiens_hsa03440	0.46227594
83	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.45589579
84	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.42974515
85	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.41686420
86	Olfactory transduction_Homo sapiens_hsa04740	0.41199179
87	Glycerolipid metabolism_Homo sapiens_hsa00561	0.41196033
88	Glutathione metabolism_Homo sapiens_hsa00480	0.39853048
89	Legionellosis_Homo sapiens_hsa05134	0.38141129
90	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.34099929
91	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.31063179
92	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.28546446
93	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.27502180
94	Collecting duct acid secretion_Homo sapiens_hsa04966	0.27115816
95	Cocaine addiction_Homo sapiens_hsa05030	0.26234890
96	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.26134117
97	Sulfur metabolism_Homo sapiens_hsa00920	0.25472208
98	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.24394197
99	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.24382173
100	Mineral absorption_Homo sapiens_hsa04978	0.23510901

RPL7AP14

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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