ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	6.61163968
2	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	6.10240644
3	high-density lipoprotein particle remodeling (GO:0034375)	6.07445445
4	base-excision repair, AP site formation (GO:0006285)	5.43895279
5	pyrimidine nucleotide catabolic process (GO:0006244)	5.20834717
6	phospholipid efflux (GO:0033700)	5.18789921
7	reverse cholesterol transport (GO:0043691)	5.16786835
8	regulation of triglyceride catabolic process (GO:0010896)	5.06016506
9	protein complex biogenesis (GO:0070271)	4.56028627
10	regulation of podosome assembly (GO:0071801)	4.55780496
11	mitochondrial respiratory chain complex assembly (GO:0033108)	4.51518295
12	water-soluble vitamin biosynthetic process (GO:0042364)	4.48397037
13	ribosomal small subunit assembly (GO:0000028)	4.33511686
14	cholesterol efflux (GO:0033344)	4.30775660
15	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.22103872
16	regulation of cholesterol esterification (GO:0010872)	4.17575982
17	plasma lipoprotein particle assembly (GO:0034377)	4.15906444
18	very-low-density lipoprotein particle assembly (GO:0034379)	4.14605247
19	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.12897521
20	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.12897521
21	NADH dehydrogenase complex assembly (GO:0010257)	4.12897521
22	plasma lipoprotein particle remodeling (GO:0034369)	4.09600396
23	protein-lipid complex remodeling (GO:0034368)	4.09600396
24	macromolecular complex remodeling (GO:0034367)	4.09600396
25	axonemal dynein complex assembly (GO:0070286)	4.03218583
26	negative regulation of lipase activity (GO:0060192)	3.94869471
27	regulation of mitochondrial translation (GO:0070129)	3.84210620
28	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.79189005
29	ATP synthesis coupled proton transport (GO:0015986)	3.68692750
30	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.68692750
31	deoxyribonucleotide catabolic process (GO:0009264)	3.57233824
32	chaperone-mediated protein transport (GO:0072321)	3.55989035
33	regulation of cilium movement (GO:0003352)	3.54209497
34	regulation of mitotic spindle checkpoint (GO:1903504)	3.44086738
35	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.44086738
36	cytochrome complex assembly (GO:0017004)	3.43370377
37	regulation of immunoglobulin secretion (GO:0051023)	3.39426384
38	respiratory chain complex IV assembly (GO:0008535)	3.37654840
39	protein-lipid complex assembly (GO:0065005)	3.32100648
40	viral transcription (GO:0019083)	3.31830127
41	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.26561357
42	regulation of isotype switching to IgG isotypes (GO:0048302)	3.25439877
43	translational termination (GO:0006415)	3.15315527
44	positive regulation of prostaglandin secretion (GO:0032308)	3.14725426
45	deoxyribose phosphate catabolic process (GO:0046386)	3.11744479
46	ribosomal large subunit biogenesis (GO:0042273)	3.11536399
47	epithelial cilium movement (GO:0003351)	3.09164059
48	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.04341496
49	peptidyl-glutamic acid carboxylation (GO:0017187)	3.03617470
50	protein carboxylation (GO:0018214)	3.03617470
51	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.01889317
52	triglyceride homeostasis (GO:0070328)	3.00423037
53	acylglycerol homeostasis (GO:0055090)	3.00423037
54	cotranslational protein targeting to membrane (GO:0006613)	2.99675228
55	L-ascorbic acid metabolic process (GO:0019852)	2.98621065
56	protein targeting to ER (GO:0045047)	2.97671102
57	plasma lipoprotein particle organization (GO:0071827)	2.95019494
58	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.91389454
59	regulation of lipoprotein metabolic process (GO:0050746)	2.91158071
60	behavioral response to nicotine (GO:0035095)	2.91126173
61	plasma lipoprotein particle clearance (GO:0034381)	2.84598424
62	negative regulation of sterol transport (GO:0032372)	2.83742690
63	negative regulation of cholesterol transport (GO:0032375)	2.83742690
64	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.83679062
65	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.82280768
66	termination of RNA polymerase III transcription (GO:0006386)	2.82280768
67	regulation of prostaglandin secretion (GO:0032306)	2.77708440
68	electron transport chain (GO:0022900)	2.77233089
69	cilium or flagellum-dependent cell motility (GO:0001539)	2.76824281
70	protein localization to endoplasmic reticulum (GO:0070972)	2.73755900
71	respiratory electron transport chain (GO:0022904)	2.73011229
72	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.70602422
73	somite rostral/caudal axis specification (GO:0032525)	2.70069720
74	positive regulation of fatty acid transport (GO:2000193)	2.69334571
75	lipoprotein transport (GO:0042953)	2.69260775
76	DNA damage response, detection of DNA damage (GO:0042769)	2.67983466
77	translational elongation (GO:0006414)	2.66508509
78	nephron tubule morphogenesis (GO:0072078)	2.66428806
79	nephron epithelium morphogenesis (GO:0072088)	2.66428806
80	cilium movement (GO:0003341)	2.66091607
81	maturation of SSU-rRNA (GO:0030490)	2.66069773
82	positive regulation of icosanoid secretion (GO:0032305)	2.64264373
83	aldehyde catabolic process (GO:0046185)	2.61997676
84	cellular component biogenesis (GO:0044085)	2.61537861
85	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.60325044
86	L-phenylalanine catabolic process (GO:0006559)	2.60325044
87	response to hydroperoxide (GO:0033194)	2.57177481
88	protein-lipid complex subunit organization (GO:0071825)	2.56633724
89	positive regulation of organelle assembly (GO:1902117)	2.55914307
90	ribosomal small subunit biogenesis (GO:0042274)	2.54111962
91	alpha-beta T cell differentiation involved in immune response (GO:0002293)	2.53620749
92	alpha-beta T cell activation involved in immune response (GO:0002287)	2.53620749
93	T cell differentiation involved in immune response (GO:0002292)	2.53620749
94	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	2.53484479
95	DNA deamination (GO:0045006)	2.51193791
96	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.49540077
97	aromatic amino acid family catabolic process (GO:0009074)	2.49437279
98	retina layer formation (GO:0010842)	2.49431887
99	cholesterol transport (GO:0030301)	2.48881939
100	sterol transport (GO:0015918)	2.48881939

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.05726626
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.79953039
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.88739443
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.75703070
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.69593118
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.52813560
7	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.32048018
8	VDR_22108803_ChIP-Seq_LS180_Human	2.28191806
9	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.14275936
10	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.13364585
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.03336393
12	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.01987592
13	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.99597695
14	ELK1_19687146_ChIP-ChIP_HELA_Human	1.97711701
15	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.94974073
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.94206458
17	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.91311910
18	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.90449076
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.90235078
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.86184096
21	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.75190711
22	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.69195003
23	EZH2_22144423_ChIP-Seq_EOC_Human	1.69087893
24	TP53_22573176_ChIP-Seq_HFKS_Human	1.66256729
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.65205454
26	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.62544448
27	VDR_23849224_ChIP-Seq_CD4+_Human	1.61324378
28	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.57387638
29	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.54721907
30	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.54359496
31	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.54250626
32	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.54200530
33	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.53609456
34	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.53394820
35	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.50297757
36	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.48768552
37	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.47072466
38	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.47065143
39	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.46140923
40	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.43859370
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.43859370
42	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.43844957
43	ERA_21632823_ChIP-Seq_H3396_Human	1.40553852
44	FOXP3_21729870_ChIP-Seq_TREG_Human	1.37980990
45	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.35335758
46	TAF15_26573619_Chip-Seq_HEK293_Human	1.34846613
47	EWS_26573619_Chip-Seq_HEK293_Human	1.31773619
48	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.30938801
49	IGF1R_20145208_ChIP-Seq_DFB_Human	1.28732642
50	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.27792725
51	P300_19829295_ChIP-Seq_ESCs_Human	1.24683302
52	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.24258726
53	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.22344438
54	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.21082388
55	TCF4_22108803_ChIP-Seq_LS180_Human	1.20890563
56	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.19871753
57	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.19376759
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18372627
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18372627
60	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.17251299
61	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.15927297
62	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.15906549
63	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.13430851
64	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.08627736
65	NCOR_22424771_ChIP-Seq_293T_Human	1.07590207
66	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07046724
67	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.06938764
68	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.06529312
69	TAF2_19829295_ChIP-Seq_ESCs_Human	1.05490883
70	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.05306442
71	ERG_20517297_ChIP-Seq_VCAP_Human	1.03151459
72	ER_23166858_ChIP-Seq_MCF-7_Human	1.02382862
73	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.02101118
74	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.02003443
75	TCF4_23295773_ChIP-Seq_U87_Human	1.00362011
76	NANOG_20526341_ChIP-Seq_ESCs_Human	0.99517191
77	P53_22387025_ChIP-Seq_ESCs_Mouse	0.99475125
78	REST_21632747_ChIP-Seq_MESCs_Mouse	0.99327725
79	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.98845417
80	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.98223930
81	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.97673951
82	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.97534493
83	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.97242694
84	MYC_19829295_ChIP-Seq_ESCs_Human	0.96276533
85	AR_20517297_ChIP-Seq_VCAP_Human	0.96102092
86	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.95837531
87	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.95230912
88	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.94935922
89	GABP_19822575_ChIP-Seq_HepG2_Human	0.94304100
90	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.92585893
91	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.92482882
92	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.92327182
93	HNF4A_19822575_ChIP-Seq_HepG2_Human	0.92196897
94	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.91621616
95	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.91599687
96	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.90873700
97	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.90838806
98	SOX2_22085726_ChIP-Seq_NPCs_Mouse	0.90079548
99	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.87836155
100	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.87242690

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009840_abnormal_foam_cell	4.68615360
2	MP0005360_urolithiasis	3.93188254
3	MP0008875_abnormal_xenobiotic_pharmacok	3.46218994
4	MP0006072_abnormal_retinal_apoptosis	3.05681207
5	MP0005084_abnormal_gallbladder_morpholo	2.73199400
6	MP0005423_abnormal_somatic_nervous	2.60850906
7	MP0003195_calcinosis	2.55109730
8	MP0001873_stomach_inflammation	2.53203636
9	MP0000372_irregular_coat_pigmentation	2.49310676
10	MP0008877_abnormal_DNA_methylation	2.47178118
11	MP0002138_abnormal_hepatobiliary_system	2.40110811
12	MP0009697_abnormal_copulation	2.26282353
13	MP0003136_yellow_coat_color	2.12526449
14	MP0005551_abnormal_eye_electrophysiolog	2.12394432
15	MP0006054_spinal_hemorrhage	1.98533314
16	MP0009379_abnormal_foot_pigmentation	1.96426795
17	MP0001529_abnormal_vocalization	1.90280271
18	MP0010329_abnormal_lipoprotein_level	1.83978881
19	MP0005377_hearing/vestibular/ear_phenot	1.81604019
20	MP0003878_abnormal_ear_physiology	1.81604019
21	MP0003890_abnormal_embryonic-extraembry	1.81289589
22	MP0004142_abnormal_muscle_tone	1.80271601
23	MP0001835_abnormal_antigen_presentation	1.79648419
24	MP0003122_maternal_imprinting	1.75223915
25	MP0003186_abnormal_redox_activity	1.75025991
26	MP0004145_abnormal_muscle_electrophysio	1.69748602
27	MP0002876_abnormal_thyroid_physiology	1.68540933
28	MP0001666_abnormal_nutrient_absorption	1.67983144
29	MP0005085_abnormal_gallbladder_physiolo	1.65484837
30	MP0003646_muscle_fatigue	1.54816812
31	MP0002139_abnormal_hepatobiliary_system	1.54072495
32	MP0006276_abnormal_autonomic_nervous	1.48771963
33	MP0001984_abnormal_olfaction	1.47091449
34	MP0005332_abnormal_amino_acid	1.45696415
35	MP0003011_delayed_dark_adaptation	1.45552201
36	MP0003252_abnormal_bile_duct	1.44173139
37	MP0005253_abnormal_eye_physiology	1.43123814
38	MP0004043_abnormal_pH_regulation	1.42765358
39	MP0005365_abnormal_bile_salt	1.40969186
40	MP0004782_abnormal_surfactant_physiolog	1.40671297
41	MP0004270_analgesia	1.39835217
42	MP0004019_abnormal_vitamin_homeostasis	1.39607701
43	MP0003121_genomic_imprinting	1.35491052
44	MP0002557_abnormal_social/conspecific_i	1.33635418
45	MP0002163_abnormal_gland_morphology	1.32011329
46	MP0002272_abnormal_nervous_system	1.31918161
47	MP0001485_abnormal_pinna_reflex	1.30309580
48	MP0008872_abnormal_physiological_respon	1.28428322
49	MP0002734_abnormal_mechanical_nocicepti	1.25395242
50	MP0003880_abnormal_central_pattern	1.24554769
51	MP0001293_anophthalmia	1.24177279
52	MP0003718_maternal_effect	1.22506196
53	MP0005645_abnormal_hypothalamus_physiol	1.21231167
54	MP0001986_abnormal_taste_sensitivity	1.20668017
55	MP0003567_abnormal_fetal_cardiomyocyte	1.18777775
56	MP0001188_hyperpigmentation	1.12655896
57	MP0001968_abnormal_touch/_nociception	1.10535159
58	MP0003868_abnormal_feces_composition	1.10365391
59	MP0001881_abnormal_mammary_gland	1.09696781
60	MP0009745_abnormal_behavioral_response	1.08898494
61	MP0003123_paternal_imprinting	1.08571217
62	MP0000427_abnormal_hair_cycle	1.07745379
63	MP0005410_abnormal_fertilization	1.07043034
64	MP0004885_abnormal_endolymph	1.05778326
65	MP0003119_abnormal_digestive_system	1.03028343
66	MP0005408_hypopigmentation	1.01590010
67	MP0008004_abnormal_stomach_pH	1.01524809
68	MP0006036_abnormal_mitochondrial_physio	1.00839629
69	MP0005379_endocrine/exocrine_gland_phen	1.00396868
70	MP0003787_abnormal_imprinting	0.98186422
71	MP0005195_abnormal_posterior_eye	0.97313287
72	MP0001324_abnormal_eye_pigmentation	0.97303754
73	MP0002090_abnormal_vision	0.94612920
74	MP0010368_abnormal_lymphatic_system	0.92036977
75	MP0004147_increased_porphyrin_level	0.91062221
76	MP0009333_abnormal_splenocyte_physiolog	0.90822848
77	MP0005448_abnormal_energy_balance	0.90420421
78	MP0005670_abnormal_white_adipose	0.89217892
79	MP0004133_heterotaxia	0.88500045
80	MP0001970_abnormal_pain_threshold	0.86749641
81	MP0001502_abnormal_circadian_rhythm	0.86168960
82	MP0008995_early_reproductive_senescence	0.85332638
83	MP0001905_abnormal_dopamine_level	0.84490851
84	MP0008789_abnormal_olfactory_epithelium	0.83455364
85	MP0005636_abnormal_mineral_homeostasis	0.83238107
86	MP0004742_abnormal_vestibular_system	0.82039628
87	MP0003936_abnormal_reproductive_system	0.81427080
88	MP0002160_abnormal_reproductive_system	0.79847273
89	MP0000049_abnormal_middle_ear	0.79457188
90	MP0005646_abnormal_pituitary_gland	0.78358811
91	MP0002638_abnormal_pupillary_reflex	0.77059725
92	MP0002928_abnormal_bile_duct	0.76531158
93	MP0006082_CNS_inflammation	0.76341444
94	MP0001440_abnormal_grooming_behavior	0.73457844
95	MP0005389_reproductive_system_phenotype	0.72788722
96	MP0002733_abnormal_thermal_nociception	0.72586580
97	MP0005387_immune_system_phenotype	0.72433758
98	MP0001790_abnormal_immune_system	0.72433758
99	MP0002938_white_spotting	0.71716100
100	MP0001348_abnormal_lacrimal_gland	0.68699171

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypobetalipoproteinemia (HP:0003563)	5.63516306
2	Abnormal respiratory motile cilium morphology (HP:0005938)	4.24674548
3	Abnormal respiratory epithelium morphology (HP:0012253)	4.24674548
4	Acute necrotizing encephalopathy (HP:0006965)	4.08590245
5	Acute encephalopathy (HP:0006846)	3.60984630
6	Supernumerary spleens (HP:0009799)	3.53620177
7	Increased hepatocellular lipid droplets (HP:0006565)	3.43313716
8	Absent/shortened dynein arms (HP:0200106)	3.42120623
9	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.42120623
10	Abnormal mitochondria in muscle tissue (HP:0008316)	3.38012314
11	Progressive macrocephaly (HP:0004481)	3.32995613
12	Mitochondrial inheritance (HP:0001427)	3.22621858
13	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.15697008
14	Abnormality of midbrain morphology (HP:0002418)	3.14024853
15	Molar tooth sign on MRI (HP:0002419)	3.14024853
16	Pancreatic cysts (HP:0001737)	3.08118582
17	Increased CSF lactate (HP:0002490)	3.06783107
18	Abnormal pancreas size (HP:0012094)	3.05473560
19	Hyperlipoproteinemia (HP:0010980)	3.03850788
20	Lipid accumulation in hepatocytes (HP:0006561)	3.02938997
21	Abnormality of urine glucose concentration (HP:0011016)	2.96008365
22	Glycosuria (HP:0003076)	2.96008365
23	Pancreatic fibrosis (HP:0100732)	2.94919471
24	Stomatitis (HP:0010280)	2.86662053
25	Rhinitis (HP:0012384)	2.86355390
26	Hyperglycinemia (HP:0002154)	2.85355064
27	Abnormal rod and cone electroretinograms (HP:0008323)	2.82245572
28	Abnormal respiratory motile cilium physiology (HP:0012261)	2.79586789
29	Congenital stationary night blindness (HP:0007642)	2.74699635
30	Spontaneous abortion (HP:0005268)	2.74488078
31	Nephronophthisis (HP:0000090)	2.68679742
32	Prolonged partial thromboplastin time (HP:0003645)	2.67394536
33	Colon cancer (HP:0003003)	2.67107084
34	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.66612672
35	Reticulocytopenia (HP:0001896)	2.65422744
36	Hypolipoproteinemia (HP:0010981)	2.64830202
37	Abnormal ciliary motility (HP:0012262)	2.63846498
38	Asplenia (HP:0001746)	2.62744486
39	Hypomagnesemia (HP:0002917)	2.57396901
40	Exertional dyspnea (HP:0002875)	2.55212576
41	Chronic sinusitis (HP:0011109)	2.53104097
42	Renal Fanconi syndrome (HP:0001994)	2.51691672
43	True hermaphroditism (HP:0010459)	2.46972917
44	Cerebral edema (HP:0002181)	2.45506868
45	Bile duct proliferation (HP:0001408)	2.42517257
46	Abnormal biliary tract physiology (HP:0012439)	2.42517257
47	Abnormality of magnesium homeostasis (HP:0004921)	2.38443287
48	3-Methylglutaconic aciduria (HP:0003535)	2.37773417
49	Malnutrition (HP:0004395)	2.33758670
50	Medial flaring of the eyebrow (HP:0010747)	2.32854542
51	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.28782066
52	Respiratory difficulties (HP:0002880)	2.28748981
53	Hepatic necrosis (HP:0002605)	2.22943531
54	Abnormality of the renal medulla (HP:0100957)	2.19829857
55	Hyperphosphaturia (HP:0003109)	2.19538735
56	Hepatocellular necrosis (HP:0001404)	2.18459476
57	Congenital primary aphakia (HP:0007707)	2.18320627
58	Parakeratosis (HP:0001036)	2.15612389
59	Joint hemorrhage (HP:0005261)	2.13708746
60	Gait imbalance (HP:0002141)	2.13592194
61	Abnormality of DNA repair (HP:0003254)	2.13560171
62	Optic disc pallor (HP:0000543)	2.13407629
63	Hyperglycinuria (HP:0003108)	2.12273682
64	Enlarged kidneys (HP:0000105)	2.11841261
65	Proximal tubulopathy (HP:0000114)	2.09605912
66	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.09023346
67	Bronchiectasis (HP:0002110)	2.08433192
68	Leukodystrophy (HP:0002415)	2.08041709
69	Congenital, generalized hypertrichosis (HP:0004540)	2.06517989
70	Thyroid-stimulating hormone excess (HP:0002925)	2.05406411
71	Renal cortical cysts (HP:0000803)	2.04902223
72	Bony spicule pigmentary retinopathy (HP:0007737)	1.98365052
73	Abnormality of the renal cortex (HP:0011035)	1.97046763
74	Adrenal hypoplasia (HP:0000835)	1.96623371
75	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.95971627
76	Cystic liver disease (HP:0006706)	1.94563287
77	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.92765818
78	Increased serum lactate (HP:0002151)	1.92547841
79	Stenosis of the external auditory canal (HP:0000402)	1.91793471
80	Large for gestational age (HP:0001520)	1.91744101
81	Nephrogenic diabetes insipidus (HP:0009806)	1.91211876
82	Tubular atrophy (HP:0000092)	1.89901893
83	Cerebral hemorrhage (HP:0001342)	1.89263234
84	Deep venous thrombosis (HP:0002625)	1.88942221
85	Nausea (HP:0002018)	1.88112423
86	Decreased central vision (HP:0007663)	1.84748479
87	Exercise intolerance (HP:0003546)	1.84520058
88	Abolished electroretinogram (ERG) (HP:0000550)	1.84399986
89	Type II lissencephaly (HP:0007260)	1.84203934
90	Pachygyria (HP:0001302)	1.81124872
91	Increased intramyocellular lipid droplets (HP:0012240)	1.79220035
92	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.78336892
93	Generalized aminoaciduria (HP:0002909)	1.76378953
94	Progressive microcephaly (HP:0000253)	1.76022679
95	Hydroxyprolinuria (HP:0003080)	1.73357932
96	Abnormality of proline metabolism (HP:0010907)	1.73357932
97	Abnormal drinking behavior (HP:0030082)	1.72818940
98	Polydipsia (HP:0001959)	1.72818940
99	Lethargy (HP:0001254)	1.71026499
100	Pendular nystagmus (HP:0012043)	1.70325685

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST4	5.53444169
2	STK16	4.67147026
3	PIK3CG	3.98570427
4	TIE1	3.34669530
5	ZAK	3.28224377
6	MUSK	3.18611021
7	BCKDK	2.69519582
8	NUAK1	2.56779201
9	NME1	2.41316631
10	FRK	2.34079109
11	WNK3	2.32292728
12	MAP3K12	2.31169528
13	GRK1	2.17568795
14	DYRK3	2.12777402
15	BMPR1B	2.11272839
16	ADRBK2	1.85779502
17	TXK	1.82623517
18	CAMKK2	1.62478976
19	PBK	1.60112272
20	CASK	1.58545710
21	WNK4	1.49360557
22	DAPK2	1.33191242
23	ACVR1B	1.28121426
24	MAP2K6	1.20425566
25	MAP3K4	1.15318467
26	TLK1	1.08916803
27	DYRK2	1.04982529
28	BUB1	1.03315816
29	PLK4	1.02369952
30	BRSK2	0.99124318
31	PDK2	0.96010007
32	PLK3	0.90558842
33	SRPK1	0.90514029
34	TTK	0.89416114
35	CDK19	0.83171354
36	CDC7	0.82802034
37	PNCK	0.82438554
38	MAP3K14	0.80969056
39	CAMK1D	0.73236261
40	PLK1	0.72999781
41	EIF2AK1	0.70899653
42	MAP2K4	0.70313089
43	INSRR	0.70270290
44	OXSR1	0.69166259
45	CAMK1G	0.67804490
46	VRK2	0.66954610
47	FGFR2	0.66676576
48	ADRBK1	0.66522992
49	PLK2	0.66522107
50	TEC	0.64737736
51	NEK1	0.64702832
52	STK3	0.61951897
53	PAK3	0.61406856
54	CAMK1	0.61350337
55	TAOK3	0.60092132
56	PRKCE	0.58682197
57	PRKCG	0.58341916
58	PRKAA2	0.57136239
59	EIF2AK3	0.56673240
60	VRK1	0.54911543
61	MKNK2	0.54552946
62	FER	0.53779041
63	CDK9	0.53720690
64	CAMK2A	0.53470201
65	PINK1	0.52106120
66	RPS6KA4	0.50713689
67	PIK3CA	0.50517318
68	CAMK4	0.50384139
69	CSNK1G2	0.48241382
70	EPHA4	0.47935505
71	WNK1	0.46888396
72	TGFBR1	0.46659962
73	CSNK1G1	0.46079997
74	FGFR1	0.45151838
75	TNIK	0.43851103
76	PRKACB	0.42691937
77	PTK2B	0.41982034
78	TESK2	0.40918755
79	MAP3K5	0.40715069
80	STK4	0.38498259
81	STK24	0.37959685
82	STK39	0.36518045
83	MAP3K11	0.36290084
84	MAPK15	0.36245090
85	CSNK1E	0.34945575
86	CSNK1G3	0.34672967
87	CSNK2A2	0.34358273
88	ATR	0.34110946
89	PRKG1	0.33214206
90	CSNK2A1	0.32452956
91	NTRK2	0.31451208
92	WEE1	0.31148031
93	PAK6	0.30831003
94	OBSCN	0.29196975
95	PRKAA1	0.28671394
96	MYLK	0.28224280
97	PRKACA	0.27812958
98	ATM	0.26700147
99	TNK2	0.26414871
100	AKT2	0.25647819

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.33338696
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.21979518
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.01348131
4	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.89255140
5	Asthma_Homo sapiens_hsa05310	2.85932113
6	Protein export_Homo sapiens_hsa03060	2.63955932
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.61244420
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.60929254
9	Parkinsons disease_Homo sapiens_hsa05012	2.49548345
10	Vitamin digestion and absorption_Homo sapiens_hsa04977	2.48312565
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.32438057
12	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.25002170
13	Proteasome_Homo sapiens_hsa03050	2.16850787
14	Allograft rejection_Homo sapiens_hsa05330	2.06843042
15	Complement and coagulation cascades_Homo sapiens_hsa04610	1.86733890
16	Homologous recombination_Homo sapiens_hsa03440	1.70391757
17	Fat digestion and absorption_Homo sapiens_hsa04975	1.68639228
18	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.63589355
19	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.62830419
20	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.61451727
21	Huntingtons disease_Homo sapiens_hsa05016	1.59675511
22	RNA polymerase_Homo sapiens_hsa03020	1.48289689
23	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.47079364
24	Chemical carcinogenesis_Homo sapiens_hsa05204	1.43544821
25	Nicotine addiction_Homo sapiens_hsa05033	1.40899890
26	Alzheimers disease_Homo sapiens_hsa05010	1.40592111
27	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.36175073
28	Retinol metabolism_Homo sapiens_hsa00830	1.33631692
29	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.30868169
30	Cardiac muscle contraction_Homo sapiens_hsa04260	1.30123053
31	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.27536843
32	Ether lipid metabolism_Homo sapiens_hsa00565	1.26921708
33	Sulfur metabolism_Homo sapiens_hsa00920	1.26196234
34	Propanoate metabolism_Homo sapiens_hsa00640	1.26137741
35	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.25859442
36	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.23539300
37	One carbon pool by folate_Homo sapiens_hsa00670	1.22452835
38	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.12443666
39	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.10920711
40	Caffeine metabolism_Homo sapiens_hsa00232	1.10462618
41	Basal transcription factors_Homo sapiens_hsa03022	1.07852560
42	Phototransduction_Homo sapiens_hsa04744	1.00518735
43	Mismatch repair_Homo sapiens_hsa03430	0.99187455
44	Mineral absorption_Homo sapiens_hsa04978	0.94964974
45	Collecting duct acid secretion_Homo sapiens_hsa04966	0.92436113
46	RNA degradation_Homo sapiens_hsa03018	0.92259118
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.91885036
48	Peroxisome_Homo sapiens_hsa04146	0.91472960
49	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.90816983
50	Tryptophan metabolism_Homo sapiens_hsa00380	0.89718020
51	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.89497137
52	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.89075791
53	Rheumatoid arthritis_Homo sapiens_hsa05323	0.87721382
54	Morphine addiction_Homo sapiens_hsa05032	0.85762648
55	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.84959475
56	Butanoate metabolism_Homo sapiens_hsa00650	0.80853273
57	PPAR signaling pathway_Homo sapiens_hsa03320	0.78705719
58	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.77798696
59	Fanconi anemia pathway_Homo sapiens_hsa03460	0.77392734
60	Nucleotide excision repair_Homo sapiens_hsa03420	0.77361870
61	GABAergic synapse_Homo sapiens_hsa04727	0.75631493
62	Folate biosynthesis_Homo sapiens_hsa00790	0.75458368
63	Galactose metabolism_Homo sapiens_hsa00052	0.75259700
64	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.74484222
65	Arginine and proline metabolism_Homo sapiens_hsa00330	0.74360983
66	Selenocompound metabolism_Homo sapiens_hsa00450	0.73653488
67	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.72838524
68	Metabolic pathways_Homo sapiens_hsa01100	0.69416374
69	Fatty acid degradation_Homo sapiens_hsa00071	0.68232124
70	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.68092024
71	Glutamatergic synapse_Homo sapiens_hsa04724	0.67880575
72	Nitrogen metabolism_Homo sapiens_hsa00910	0.65414553
73	Serotonergic synapse_Homo sapiens_hsa04726	0.65367983
74	Glycerolipid metabolism_Homo sapiens_hsa00561	0.64942683
75	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.64127969
76	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.63997577
77	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.58774877
78	Purine metabolism_Homo sapiens_hsa00230	0.54623809
79	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.49553596
80	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.49347270
81	Type I diabetes mellitus_Homo sapiens_hsa04940	0.49246107
82	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.48728043
83	Arginine biosynthesis_Homo sapiens_hsa00220	0.47795401
84	Bile secretion_Homo sapiens_hsa04976	0.46941046
85	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.46049607
86	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.45320014
87	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.44854494
88	Pyrimidine metabolism_Homo sapiens_hsa00240	0.41968622
89	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.41686431
90	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.41110803
91	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.40344085
92	Graft-versus-host disease_Homo sapiens_hsa05332	0.39684968
93	ABC transporters_Homo sapiens_hsa02010	0.38044836
94	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.35212862
95	beta-Alanine metabolism_Homo sapiens_hsa00410	0.35039815
96	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.30037908
97	Steroid biosynthesis_Homo sapiens_hsa00100	0.29536835
98	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.28989805
99	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.28686346
100	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.28180357

RPL7AP15

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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